EuRBPDB

Ensembl ID

ENSG00000111335 (Gene tree)

Gene ID

4939

Gene Symbol

OAS2

Alias

N

Full Name

2'-5'-oligoadenylate synthetase 2

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

40,905 bases

Position

chr12:112,970,819-113,011,723

Accession

8087

Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]