EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18264137Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.Oncogene2008 Jun 26Tucker LAdoi: 10.1038/onc.2008.14
11994292Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.J Biol Chem2002 Jul 19Endo H-
15336565Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.Biochem Biophys Res Commun2004 Sep 24Selvakumar P-
27542228MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.Oncotarget2016 Sep 27Frottin Fdoi: 10.18632/oncotarget.11216.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12954741415'UTRrs1132747110.2
BLCAchr1295496051Missense_MutationnovelD274N0.26
BLCAchr1295496096Missense_MutationnovelK289Q0.43
BLCAchr1295512891Missense_MutationNAF387V0.42
BLCAchr12954741415'UTRrs1132747110.31
BLCAchr12954741625'UTRnovel0.19
BRCAchr1295513720Missense_MutationnovelR418K0.3
BRCAchr1295495123Nonsense_MutationNAG253*0.57
BRCAchr1295495124Missense_MutationNAG253V0.58
BRCAchr12955142643'UTRnovel0.07
BRCAchr1295494980Missense_Mutationrs752983315R205H0.04
BRCAchr1295511981Missense_MutationnovelE351K0.1
BRCAchr1295494958Nonsense_MutationNAE198*0.1
BRCAchr1295511897Nonsense_MutationNAK323*0.11
CESCchr1295496051Missense_MutationnovelD274N0.18
CESCchr1295485947Nonsense_MutationnovelG132*0.5
CESCchr12955144183'UTRnovel0.63
CESCchr1295494206Missense_MutationnovelM193I0.38
COADchr1295513835Silentrs112506052A456A0.29
COADchr1295476078SilentnovelE53E0.06
COADchr1295485953Nonsense_MutationnovelE134*0.17
COADchr1295494100Missense_MutationNAL158S0.26
COADchr1295476142Missense_MutationNAA75T0.37
COADchr1295511925Nonsense_MutationNAS332*0.19
COADchr1295494090Missense_MutationNAK155Q0.46
COADchr12955139633'UTRnovel0.21
COADchr1295512823Frame_Shift_DelnovelT365Pfs*200.23
COADchr1295504105Missense_MutationNAA303V0.09
COADchr1295476085Frame_Shift_InsnovelP56Qfs*140.07
COADchr1295476086Frame_Shift_InsnovelD57Lfs*30.07
ESCAchr1295512825Missense_MutationnovelT365A0.6
GBMchr1295474275Missense_MutationnovelE32D0.41
HNSCchr1295474295Missense_MutationnovelR39T0.17
HNSCchr1295494084Missense_MutationnovelE153K0.2
HNSCchr1295476070Splice_SitenovelX51_splice0.36
KIRCchr1295494955Splice_Siters781369643X197_splice0.26
KIRPchr1295513892SilentnovelG475G0.28
KIRPchr1295513662Missense_MutationNAT399A0.24
KIRPchr12955139283'UTRrs7730518620.17
KIRPchr12954740695'UTRnovel0.79
LGGchr1295494057Nonsense_Mutationrs780306578R144*0.45
LGGchr1295511940Missense_MutationnovelR337I0.22
LGGchr1295513866Missense_MutationnovelT467A0.08
LIHCchr1295474192Missense_MutationnovelE5K0.43
LIHCchr1295511902SilentNAP324P0.3
LIHCchr1295474184Missense_MutationnovelA2V0.22
LUADchr12954741785'UTRnovel0.44
LUADchr1295483249Missense_MutationnovelK98N0.26
LUADchr1295476135Frame_Shift_InsnovelR73Nfs*90.13
LUADchr1295476137Missense_MutationnovelR73K0.13
LUSCchr1295474269SilentnovelT30T0.15
LUSCchr1295513705Missense_MutationNAL413P0.22
LUSCchr1295513656Missense_MutationNAP397S0.25
LUSCchr12955140303'UTRnovel0.24
LUSCchr12954740895'UTRnovel0.27
LUSCchr1295511934Frame_Shift_DelnovelQ335Hfs*130.27
OVchr1295513890Missense_MutationNAG475R0.25
OVchr1295494173Silentrs141578207Y182Y0.44
PAADchr1295513717Missense_MutationNAR417H0.04
PRADchr1295474256Missense_MutationnovelG26E0.34
PRADchr1295495133Missense_MutationNAI256T0.28
READchr1295476155Missense_MutationnovelK79T0.43
READchr1295485913Missense_MutationnovelI120M0.25
SARCchr12955140603'UTRnovel0.4
SKCMchr1295476112Missense_MutationNAD65N0.51
SKCMchr12954740995'UTRnovel0.68
SKCMchr12954740695'UTRnovel0.45
SKCMchr1295511905SilentnovelI325I0.29
SKCMchr1295485896Missense_MutationNAP115S0.35
SKCMchr12954740705'UTRnovel0.27
SKCMchr1295496022Missense_MutationnovelA264V0.22
SKCMchr12954740695'UTRnovel0.29
SKCMchr1295494061Missense_MutationNAT145R0.57
SKCMchr12954740545'UTRnovel0.25
SKCMchr1295513731Missense_Mutationrs754957570R422C0.18
STADchr1295512891Missense_MutationNAF387V0.32
STADchr1295494980Missense_Mutationrs752983315R205H0.33
STADchr1295494083SilentNAS152S0.61
STADchr12955139453'UTRnovel0.08
UCECchr1295474302SilentNAK41K0.42
UCECchr1295511963Missense_MutationnovelP345S0.18
UCECchr1295511920Silentrs757091265G330G0.36
UCECchr1295496099Splice_SitenovelX289_splice0.47
UCECchr1295511906Missense_MutationnovelR326C0.21
UCECchr1295494060Missense_Mutationrs776632195T145A0.1
UCECchr1295495034Missense_MutationnovelC223Y0.18
UCECchr1295485881Missense_Mutationrs200917784K110E0.28
UCECchr1295504083Missense_MutationnovelR296C0.3
UCECchr1295476092Missense_MutationNAK58T0.32
UCECchr1295496056Silentrs764203985T275T0.11
UCECchr1295495068SilentnovelP234P0.2
UCECchr12955152683'UTRnovel0.25
UCECchr1295512891Missense_MutationNAF387V0.44
UCECchr1295476132Silentrs200315154L71L0.5
UCECchr1295494092Missense_MutationnovelK155N0.53
UCECchr12955141993'UTRnovel0.37
UCECchr1295483225Silentrs200687006G90G0.29
UCECchr12955139673'UTRnovel0.31
UCECchr1295511912Missense_MutationnovelL328I0.3
UCECchr1295474294Missense_MutationnovelR39G0.52
UCECchr1295496055Missense_Mutationrs201728792T275M0.34
UCECchr12955141993'UTRnovel0.42
UCECchr12955143063'UTRnovel0.4
UCECchr1295476104Missense_MutationnovelA62V0.67
UCECchr1295512902SilentnovelG390G0.51
UCECchr1295513712Missense_MutationnovelF415L0.53
UCECchr12955141993'UTRnovel0.14
UCECchr1295512856Missense_MutationNAH375R0.15
UCECchr1295494210Nonsense_MutationnovelE195*0.46
UCECchr12955149803'UTRnovel0.57
UCECchr1295483225Silentrs200687006G90G0.27
UCECchr1295496010Missense_MutationnovelI260S0.15
UCECchr12955149893'UTRnovel0.24
UCECchr12954741325'UTRrs7642226480.32
UCECchr1295494119Missense_Mutationrs147951626E164D0.32
UCECchr1295494189Missense_MutationNAK188E0.19
UCECchr12955140453'UTRnovel0.5
UCECchr1295512882Missense_MutationNAM384V0.46
UCECchr1295511999Splice_SitenovelX356_splice0.11
UCECchr1295504149Nonsense_MutationnovelK318delinsMVKCG*0.03
UCECchr1295494173Silentrs141578207Y182Y0.3
UCECchr1295496067Missense_MutationnovelA279V0.33
UCECchr1295496052Missense_MutationNAD274G0.28
UCECchr1295474281SilentnovelA34A0.44
UCSchr1295474325Missense_Mutationrs199968706S49Y0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.02220.20414
CHOLDEL0.19440.067545
ESCADEL0.1630.045584
HNSCDEL0.06510.22646
LAMLDEL0.01050.097556
LUADDEL0.14340.0059643
MESODEL0.0460.014499
PAADAMP0.05980.1091
PAADDEL0.19020.2014
PRADAMP0.0610.016187
READDEL0.09090.064633
SKCMDEL0.19890.00079981

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

ACC0.0058

Kaplan-Meier Survival Analysis

UCS0.014

Kaplan-Meier Survival Analysis

HNSC0.028

Kaplan-Meier Survival Analysis

KIRP0.0018

Kaplan-Meier Survival Analysis

KICH0.047

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • PRI
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000111142 (Gene tree)
Gene ID
10988
Gene Symbol
METAP2
Alias
MNPEP|p67|MAP2
Full Name
methionyl aminopeptidase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
42,320 bases
Position
chr12:95,473,520-95,515,839
Accession
16672
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000546753METAP2-2051862-ENSP00000448169455 (aa)-P50579
ENST00000549502METAP2-207513-ENSP00000448370161 (aa)-F8VSC4
ENST00000553151METAP2-211564-ENSP00000449004178 (aa)-F8VY03
ENST00000261220METAP2-2011836-ENSP00000261220455 (aa)-P50579
ENST00000549808METAP2-208538-ENSP00000447661163 (aa)-F8VZX9
ENST00000549136METAP2-206388--- (aa)--
ENST00000535095METAP2-2032431-ENSP00000446052328 (aa)-G3V1U3
ENST00000323666METAP2-2023601-ENSP00000325312478 (aa)-P50579
ENST00000550777METAP2-2091779-ENSP00000448614442 (aa)-F8VRR3
ENST00000551840METAP2-2101874-ENSP00000450063477 (aa)-F8VQZ7
ENST00000546478METAP2-204232--- (aa)--
Gene Model
Click here to download ENSG00000111142's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000111142rs3010431295493245GImmature fraction of reticulocytes27863252[0.024-0.039] unit decrease0.03181796EFO_0007986
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111142's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000111142METAP210095.188ENSMUSG00000036112Metap210099.057Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0004177aminopeptidase activity8858118.IDAFunction
GO:0005737cytoplasm15102683.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0008235metalloexopeptidase activity8858118.IDAFunction
GO:0016485protein processing8858118.IDAProcess
GO:0018206peptidyl-methionine modification8858118.IDAProcess
GO:0022400regulation of rhodopsin mediated signaling pathway-TASProcess
GO:0031365N-terminal protein amino acid modification8858118.IDAProcess
GO:0046872metal ion binding-IEAFunction
GO:0070006metalloaminopeptidase activity-IEAFunction
GO:0070084protein initiator methionine removal-IEAProcess
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