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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26892177Downregulation of cytokeratin 18 is associated with paclitaxelresistance and tumor aggressiveness in prostate cancer.Int J Oncol2016 AprYin Bdoi: 10.3892/ijo.2016.3396
19302716Circulating cell death products predict clinical outcome of colorectal cancer patients.BMC Cancer2009 Mar 23Koelink PJdoi: 10.1186/1471-2407-9-88.
29863745Quantification of the heterogeneity of cytokeratin 18 immunoexpression in prostate adenocarcinoma and normal prostate: Global and local features.Histol Histopathol2018 OctSantamar??a Ldoi: 10.14670/HH-18-009
19575986[Correlation between the expression of cytokeratin-18-mRNA and invasion and metastasis of oral squamous cell carcinoma].Zhonghua Kou Qiang Yi Xue Za Zhi2009 MayShu P-
26911253Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells.J Ovarian Res2016 Feb 24Trisdale SKdoi: 10.1186/s13048-016-0217-z.
27706656Evaluation of serum HGF and CK18 levels in patients with esophageal cancer.Genet Mol Res2016 Aug 29Kilic-Baygutalp Ndoi: 10.4238/gmr.15038583.
16046547Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo.Mol Cancer Res2005 JulB??hler H-
23449973Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.J Biol Chem2013 Apr 19Fortier AMdoi: 10.1074/jbc.M112.428920
27601168Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer.J Cancer Res Clin Oncol2016 DecZhang B-
28468590UBC Rapid Test for detection of carcinoma in situ for bladder cancer.Tumour Biol2017 MayEcke THdoi: 10.1177/1010428317701624.
25326440Diagnostic value of serum M30 and M65 in patients with nasopharyngeal carcinoma.Tumour Biol2015 FebSen Fdoi: 10.1007/s13277-014-2708-0
25973684Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins.Sci Rep2015 May 14Wang Xdoi: 10.1038/srep10293.
19727975Circulating cytokeratin 18 fragment m65-a potential marker of malignancy in colorectal cancer patients.J Gastrointest Surg2009 NovAusch Cdoi: 10.1007/s11605-009-0992-6
23341946Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines.PLoS One2013Iyer SVdoi: 10.1371/journal.pone.0053532
23767766The clinical significance of apoptosis and M30 expression in colonic cancer progression.J Recept Signal Transduct Res2013 AugKykalos Sdoi: 10.3109/10799893.2013.802804
18705345Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR.Hepatogastroenterology2008 May-JunKoga T-
22699783The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.Cancer Biomark2011Ha SAdoi: 10.3233/CBM-2012-0250.
22191568Bromelain-induced apoptosis in GI-101A breast cancer cells.J Med Food2012 AprDhandayuthapani Sdoi: 10.1089/jmf.2011.0145
11923318Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas.J Biol Chem2002 Jun 14Ditzel HJ-
14556659Ubiquitin-immunoreactive degradation products of cytokeratin 8/18 correlate with aggressive breast cancer.Cancer Sci2003 OctIwaya K-
23154549Can determination of circulating endothelial cells and serum caspase-cleaved CK18 predict for response and survival in patients with advanced non-small-cell lung cancer receiving endostatin and paclitaxel-carboplatin chemotherapy? a retrospective study.J Thorac Oncol2012 DecChu TQdoi: 10.1097/JTO.0b013e3182725fe0.
27468866M30/M65 ratio predicts the outcome of paclitaxel chemotherapy for NSCLC.Clin Transl Oncol2017 MarChu Tdoi: 10.1007/s12094-016-1533-x
17545523Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.Clin Cancer Res2007 Jun 1Olofsson MH-
25028131Dynamic dialog between cytokeratin 18 and annexin A1 in breast cancer: a transcriptional disequilibrium.Acta Histochem2014 SepAraujo TGdoi: 10.1016/j.acthis.2014.06.008
21460362Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.Acta Biochim Biophys Sin (Shanghai)2011 MayWang Hdoi: 10.1093/abbs/gmr022
21119362Cytokeratin 18 expression inhibits cytokine-induced death of cervical cancer cells.Int J Gynecol Cancer2010 DecSullivan BTdoi: 10.1111/IGC.0b013e3181fc3a03.
15102669Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer.Clin Cancer Res2004 Apr 15Woelfle U-
23536001The prognostic importance of changing serum M30 and M65 values after chemotherapy in patients with advanced-stage non-small-cell lung cancer.Med Oncol2013 JunUstaalioglu BBdoi: 10.1007/s12032-013-0551-6
22890829The prognostic significance of the increase in the serum M30 and M65 values after chemotherapy and relationship between these values and clinicopathological factors in patients with advanced gastric cancer.Tumour Biol2012 DecBilici Adoi: 10.1007/s13277-012-0481-5
29437899Prognostic value and clinicopathological significance of serum- and tissue-based cytokeratin 18 express level in breast cancer: a meta-analysis.Biosci Rep2018 Mar 21Yang Jdoi: 10.1042/BSR20171145

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12529490735'UTRnovel0.38
BLCAchr1252950391Missense_MutationnovelA161S0.34
BLCAchr1252952283SilentnovelV371V0.6
BLCAchr1252949393Missense_MutationNAM74L0.35
BLCAchr12529491435'UTRnovel0.42
BLCAchr1252949625Intronnovel0.45
BLCAchr1252951560Missense_MutationNAA246D0.29
BLCAchr1252951733Missense_MutationNAI275M0.19
BLCAchr12529491435'UTRnovel0.15
BRCAchr1252950742Splice_Regionnovel0.21
BRCAchr1252951734Missense_MutationNAE276Q0.43
BRCAchr1252950795SilentNAI182I0.33
BRCAchr1252950867SilentNAL206L0.44
BRCAchr1252951734Missense_MutationNAE276Q0.32
BRCAchr1252949438Missense_MutationNAD89N0.29
CESCchr1252950858Silentrs752822458I203I0.35
CESCchr12529491645'UTRnovel0.35
CESCchr1252950859Missense_MutationNAE204Q0.26
CESCchr1252950901Missense_Mutationrs375823747E218K0.17
CHOLchr1252950745Splice_Regionnovel0.3
COADchr1252950863Missense_MutationNAA205V0.47
COADchr1252950806Missense_Mutationrs773737254R186H0.38
COADchr12529491145'UTRnovel0.25
COADchr12529491535'UTRNA0.23
COADchr1252949412In_Frame_DelNAK81del0.4
COADchr1252952302Missense_MutationNAA378S0.32
COADchr1252952119Missense_MutationNAK317E0.13
COADchr1252949354Missense_MutationNAG61R0.52
COADchr1252949534Missense_Mutationrs796088051P121S0.21
COADchr1252949632IntronNA0.32
COADchr1252952690Intronnovel0.25
ESCAchr1252952663Intronnovel0.44
ESCAchr1252951577Missense_MutationnovelI252V0.35
ESCAchr1252952248Frame_Shift_InsnovelQ361Pfs*40.53
GBMchr1252952312Missense_Mutationrs147541172R381H0.38
GBMchr12529491475'UTRnovel0.38
GBMchr1252951548Missense_MutationnovelS242Y0.26
GBMchr1252949437SilentNAN88N0.36
GBMchr1252951737Missense_MutationnovelE277Q0.18
GBMchr1252952734SilentnovelA395A0.03
GBMchr1252951765Missense_MutationNAS286Y0.12
GBMchr1252950409Missense_MutationnovelK167E0.1
GBMchr1252951580Missense_MutationNAR253W0.32
HNSCchr1252952833SilentnovelL428L0.08
HNSCchr1252952781Missense_Mutationrs148580152R411H0.32
HNSCchr1252952633Intronnovel0.22
HNSCchr1252949566SilentnovelK131K0.3
KIRCchr1252950484Intronnovel0.33
KIRCchr12529491265'UTRrs7585669100.27
KIRPchr1252952637Intronnovel0.06
LGGchr1252950858Silentrs752822458I203I0.45
LIHCchr1252952141Missense_MutationNAL324Q0.4
LIHCchr1252949500SilentnovelE109E0.14
LIHCchr1252950568IntronNA0.47
LUADchr1252950526Intronnovel0.18
LUADchr1252952211SilentnovelS347S0.2
LUADchr12529491115'UTRnovel0.13
LUADchr1252952630Intronnovel0.2
LUADchr12529491135'UTRnovel0.16
LUADchr1252950424Intronnovel0.18
LUSCchr1252951585Silentrs145578755A254A0.32
LUSCchr1252951822Missense_MutationNAS305F0.11
LUSCchr1252952184SilentnovelL338L0.47
LUSCchr12529490975'UTRnovel0.16
OVchr1252951760SilentnovelT284T0.06
OVchr1252949613Intronnovel0.36
OVchr1252952696Intronrs3706183010.1
OVchr1252952713Intronnovel0.09
OVchr1252952576Intronnovel0.12
OVchr12529491215'UTRnovel0.33
OVchr12529491155'UTRnovel0.2
PRADchr1252949352Missense_MutationnovelS60Y0.46
PRADchr1252952638Intronnovel0.43
READchr1252950674Intronnovel0.57
SKCMchr1252950360SilentNAI150I0.41
SKCMchr1252951535Missense_MutationNAD238N0.57
SKCMchr1252952671Intronnovel0.18
SKCMchr1252952784Missense_Mutationrs146080391R412Q0.31
SKCMchr1252951844SilentNAS312S0.34
SKCMchr1252951504SilentNAQ227Q0.98
SKCMchr1252950500Intronnovel0.24
SKCMchr12529491535'UTRNA0.27
SKCMchr1252949256Missense_MutationNAP28L0.35
SKCMchr1252949604Intronnovel0.24
SKCMchr1252950561Intronnovel0.24
SKCMchr1252952214SilentNAE348E0.44
SKCMchr1252951614Missense_Mutationrs762129501R264Q0.58
SKCMchr1252951832Silentrs149270992I308I0.57
SKCMchr1252949411Missense_Mutationrs199572098E80K0.34
SKCMchr1252951507Missense_MutationNAI228M0.24
SKCMchr1252950460Intronnovel0.07
SKCMchr12529528503'UTRnovel0.43
SKCMchr1252950804SilentNAL185L0.48
SKCMchr1252949554SilentnovelS127S0.86
SKCMchr1252949416SilentnovelK81K0.63
SKCMchr1252950460Intronnovel0.46
SKCMchr1252949657Intronnovel0.19
STADchr1252952819Missense_MutationNAD424Y0.09
STADchr1252951620Missense_MutationnovelE266V0.09
STADchr1252949396Missense_MutationNAG75R0.32
STADchr1252949633Intronnovel0.42
STADchr1252950858Silentrs752822458I203I0.66
STADchr1252952646Intronnovel0.11
STADchr1252952697Intronnovel0.18
STADchr1252951595Missense_MutationnovelE258K0.29
STADchr1252949295Missense_MutationnovelG41D0.37
THCAchr1252952254Missense_MutationNAE362K0.24
UCECchr1252949591Splice_SiteNAX139_splice0.19
UCECchr1252952568Intronnovel0.33
UCECchr1252952599Intronnovel0.44
UCECchr1252950874Missense_MutationnovelE209K0.21
UCECchr1252950853Nonsense_MutationnovelE202*0.21
UCECchr1252949286Missense_MutationnovelG38D0.52
UCECchr1252951529Missense_MutationNAE236K0.32
UCECchr12529491455'UTRNA0.16
UCECchr1252949488SilentnovelN105N0.13
UCECchr1252952231Missense_MutationnovelA354V0.43
UCECchr1252949383SilentnovelG70G0.33
UCECchr12529491495'UTRNA0.48
UCECchr1252950884Missense_MutationnovelF212S0.18
UCECchr1252950505Intronnovel0.14
UCECchr1252951793Silentrs756436730T295T0.36
UCSchr1252949532Missense_MutationnovelG120E0.21

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.18750.085003
READDEL0.06670.064633
STADDEL0.09520.22179

Survival Analysis
CancerP-value Q-value
SARC0.03

Kaplan-Meier Survival Analysis

ACC0.03

Kaplan-Meier Survival Analysis

HNSC0.0065

Kaplan-Meier Survival Analysis

SKCM0.036

Kaplan-Meier Survival Analysis

ESCA0.045

Kaplan-Meier Survival Analysis

PAAD0.00017

Kaplan-Meier Survival Analysis

UCEC0.014

Kaplan-Meier Survival Analysis

GBM0.015

Kaplan-Meier Survival Analysis

LIHC0.0059

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.04

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000111057 (Gene tree)
Gene ID
3875
Gene Symbol
KRT18
Alias
N
Full Name
keratin 18
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,031 bases
Position
chr12:52,948,871-52,952,901
Accession
6430
RBP type
non-canonical RBP
Summary
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21283634Tumor suppression by RNA from C/EBP-and-beta; 3'UTR through the inhibition of protein kinase C-epsilon activity.PLoS One2011 Jan 24Wang Ydoi: 10.1371/journal.pone.0016543.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000549078KRT18-2062088--- (aa)--
ENST00000548496KRT18-205695--- (aa)--
ENST00000388837KRT18-2021420-ENSP00000373489430 (aa)-P05783
ENST00000388835KRT18-2011562-ENSP00000373487430 (aa)-P05783
ENST00000550600KRT18-2071696-ENSP00000447278391 (aa)-F8VZY9
ENST00000546656KRT18-203521--- (aa)--
ENST00000548015KRT18-204928--- (aa)--
Gene Model
Click here to download ENSG00000111057's gene model file
Pathways
Pathway IDPathway NameSource
hsa04915Estrogen signaling pathwayKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000111057Cleft Lip6E-628054174
ENSG00000111057Cleft Palate6E-628054174
ENSG00000111057Cleft Lip4E-1228232668
ENSG00000111057Cleft Palate4E-1228232668
ENSG00000111057Cleft Lip2E-728054174
ENSG00000111057Cleft Palate2E-728054174
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111057's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005198structural molecule activity-IEAFunction
GO:0005515protein binding10852826.10954706.11684708.14756564.15671067.15731013.15846844.16189514.19549727.20035625.21988832.23112296.25416956.25910212.26769854.26871637.30021884.IPIFunction
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm16424149.20346438.IDAComponent
GO:0005815microtubule organizing center18000879.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005882intermediate filament10852826.IDAComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0007049cell cycle-IEAProcess
GO:0009653anatomical structure morphogenesis2434380.TASProcess
GO:0016032viral process-IEAProcess
GO:0031424keratinization-TASProcess
GO:0033209tumor necrosis factor-mediated signaling pathway-IEAProcess
GO:0034451centriolar satellite18000879.IDAComponent
GO:0043000Golgi to plasma membrane CFTR protein transport15529338.IDAProcess
GO:0043066negative regulation of apoptotic process11684708.IDAProcess
GO:0045095keratin filament16424149.IDAComponent
GO:0045104intermediate filament cytoskeleton organization20346438.IDAProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0070062extracellular exosome19199708.HDAComponent
GO:0070268cornification-TASProcess
GO:0071944cell periphery-IEAComponent
GO:0097110scaffold protein binding10852826.IPIFunction
GO:0097191extrinsic apoptotic signaling pathway-IEAProcess
GO:0097284hepatocyte apoptotic process-IEAProcess
GO:0098609cell-cell adhesion-IEAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.HDAFunction
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