EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26892177	Downregulation of cytokeratin 18 is associated with paclitaxelresistance and tumor aggressiveness in prostate cancer.	Int J Oncol	2016 Apr	Yin B	doi: 10.3892/ijo.2016.3396
19302716	Circulating cell death products predict clinical outcome of colorectal cancer patients.	BMC Cancer	2009 Mar 23	Koelink PJ	doi: 10.1186/1471-2407-9-88.
29863745	Quantification of the heterogeneity of cytokeratin 18 immunoexpression in prostate adenocarcinoma and normal prostate: Global and local features.	Histol Histopathol	2018 Oct	Santamar??a L	doi: 10.14670/HH-18-009
19575986	[Correlation between the expression of cytokeratin-18-mRNA and invasion and metastasis of oral squamous cell carcinoma].	Zhonghua Kou Qiang Yi Xue Za Zhi	2009 May	Shu P	-
26911253	Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells.	J Ovarian Res	2016 Feb 24	Trisdale SK	doi: 10.1186/s13048-016-0217-z.
27706656	Evaluation of serum HGF and CK18 levels in patients with esophageal cancer.	Genet Mol Res	2016 Aug 29	Kilic-Baygutalp N	doi: 10.4238/gmr.15038583.
16046547	Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo.	Mol Cancer Res	2005 Jul	B??hler H	-
23449973	Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.	J Biol Chem	2013 Apr 19	Fortier AM	doi: 10.1074/jbc.M112.428920
27601168	Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer.	J Cancer Res Clin Oncol	2016 Dec	Zhang B	-
28468590	UBC Rapid Test for detection of carcinoma in situ for bladder cancer.	Tumour Biol	2017 May	Ecke TH	doi: 10.1177/1010428317701624.
25326440	Diagnostic value of serum M30 and M65 in patients with nasopharyngeal carcinoma.	Tumour Biol	2015 Feb	Sen F	doi: 10.1007/s13277-014-2708-0
25973684	Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins.	Sci Rep	2015 May 14	Wang X	doi: 10.1038/srep10293.
19727975	Circulating cytokeratin 18 fragment m65-a potential marker of malignancy in colorectal cancer patients.	J Gastrointest Surg	2009 Nov	Ausch C	doi: 10.1007/s11605-009-0992-6
23341946	Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines.	PLoS One	2013	Iyer SV	doi: 10.1371/journal.pone.0053532
23767766	The clinical significance of apoptosis and M30 expression in colonic cancer progression.	J Recept Signal Transduct Res	2013 Aug	Kykalos S	doi: 10.3109/10799893.2013.802804
18705345	Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR.	Hepatogastroenterology	2008 May-Jun	Koga T	-
22699783	The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.	Cancer Biomark	2011	Ha SA	doi: 10.3233/CBM-2012-0250.
22191568	Bromelain-induced apoptosis in GI-101A breast cancer cells.	J Med Food	2012 Apr	Dhandayuthapani S	doi: 10.1089/jmf.2011.0145
11923318	Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas.	J Biol Chem	2002 Jun 14	Ditzel HJ	-
14556659	Ubiquitin-immunoreactive degradation products of cytokeratin 8/18 correlate with aggressive breast cancer.	Cancer Sci	2003 Oct	Iwaya K	-
23154549	Can determination of circulating endothelial cells and serum caspase-cleaved CK18 predict for response and survival in patients with advanced non-small-cell lung cancer receiving endostatin and paclitaxel-carboplatin chemotherapy? a retrospective study.	J Thorac Oncol	2012 Dec	Chu TQ	doi: 10.1097/JTO.0b013e3182725fe0.
27468866	M30/M65 ratio predicts the outcome of paclitaxel chemotherapy for NSCLC.	Clin Transl Oncol	2017 Mar	Chu T	doi: 10.1007/s12094-016-1533-x
17545523	Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.	Clin Cancer Res	2007 Jun 1	Olofsson MH	-
25028131	Dynamic dialog between cytokeratin 18 and annexin A1 in breast cancer: a transcriptional disequilibrium.	Acta Histochem	2014 Sep	Araujo TG	doi: 10.1016/j.acthis.2014.06.008
21460362	Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.	Acta Biochim Biophys Sin (Shanghai)	2011 May	Wang H	doi: 10.1093/abbs/gmr022
21119362	Cytokeratin 18 expression inhibits cytokine-induced death of cervical cancer cells.	Int J Gynecol Cancer	2010 Dec	Sullivan BT	doi: 10.1111/IGC.0b013e3181fc3a03.
15102669	Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer.	Clin Cancer Res	2004 Apr 15	Woelfle U	-
23536001	The prognostic importance of changing serum M30 and M65 values after chemotherapy in patients with advanced-stage non-small-cell lung cancer.	Med Oncol	2013 Jun	Ustaalioglu BB	doi: 10.1007/s12032-013-0551-6
22890829	The prognostic significance of the increase in the serum M30 and M65 values after chemotherapy and relationship between these values and clinicopathological factors in patients with advanced gastric cancer.	Tumour Biol	2012 Dec	Bilici A	doi: 10.1007/s13277-012-0481-5
29437899	Prognostic value and clinicopathological significance of serum- and tissue-based cytokeratin 18 express level in breast cancer: a meta-analysis.	Biosci Rep	2018 Mar 21	Yang J	doi: 10.1042/BSR20171145

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	52949073	5'UTR	novel		0.38
BLCA	chr12	52950391	Missense_Mutation	novel	A161S	0.34
BLCA	chr12	52952283	Silent	novel	V371V	0.6
BLCA	chr12	52949393	Missense_Mutation	NA	M74L	0.35
BLCA	chr12	52949143	5'UTR	novel		0.42
BLCA	chr12	52949625	Intron	novel		0.45
BLCA	chr12	52951560	Missense_Mutation	NA	A246D	0.29
BLCA	chr12	52951733	Missense_Mutation	NA	I275M	0.19
BLCA	chr12	52949143	5'UTR	novel		0.15
BRCA	chr12	52950742	Splice_Region	novel		0.21
BRCA	chr12	52951734	Missense_Mutation	NA	E276Q	0.43
BRCA	chr12	52950795	Silent	NA	I182I	0.33
BRCA	chr12	52950867	Silent	NA	L206L	0.44
BRCA	chr12	52951734	Missense_Mutation	NA	E276Q	0.32
BRCA	chr12	52949438	Missense_Mutation	NA	D89N	0.29
CESC	chr12	52950858	Silent	rs752822458	I203I	0.35
CESC	chr12	52949164	5'UTR	novel		0.35
CESC	chr12	52950859	Missense_Mutation	NA	E204Q	0.26
CESC	chr12	52950901	Missense_Mutation	rs375823747	E218K	0.17
CHOL	chr12	52950745	Splice_Region	novel		0.3
COAD	chr12	52950863	Missense_Mutation	NA	A205V	0.47
COAD	chr12	52950806	Missense_Mutation	rs773737254	R186H	0.38
COAD	chr12	52949114	5'UTR	novel		0.25
COAD	chr12	52949153	5'UTR	NA		0.23
COAD	chr12	52949412	In_Frame_Del	NA	K81del	0.4
COAD	chr12	52952302	Missense_Mutation	NA	A378S	0.32
COAD	chr12	52952119	Missense_Mutation	NA	K317E	0.13
COAD	chr12	52949354	Missense_Mutation	NA	G61R	0.52
COAD	chr12	52949534	Missense_Mutation	rs796088051	P121S	0.21
COAD	chr12	52949632	Intron	NA		0.32
COAD	chr12	52952690	Intron	novel		0.25
ESCA	chr12	52952663	Intron	novel		0.44
ESCA	chr12	52951577	Missense_Mutation	novel	I252V	0.35
ESCA	chr12	52952248	Frame_Shift_Ins	novel	*Q361Pfs4**	0.53
GBM	chr12	52952312	Missense_Mutation	rs147541172	R381H	0.38
GBM	chr12	52949147	5'UTR	novel		0.38
GBM	chr12	52951548	Missense_Mutation	novel	S242Y	0.26
GBM	chr12	52949437	Silent	NA	N88N	0.36
GBM	chr12	52951737	Missense_Mutation	novel	E277Q	0.18
GBM	chr12	52952734	Silent	novel	A395A	0.03
GBM	chr12	52951765	Missense_Mutation	NA	S286Y	0.12
GBM	chr12	52950409	Missense_Mutation	novel	K167E	0.1
GBM	chr12	52951580	Missense_Mutation	NA	R253W	0.32
HNSC	chr12	52952833	Silent	novel	L428L	0.08
HNSC	chr12	52952781	Missense_Mutation	rs148580152	R411H	0.32
HNSC	chr12	52952633	Intron	novel		0.22
HNSC	chr12	52949566	Silent	novel	K131K	0.3
KIRC	chr12	52950484	Intron	novel		0.33
KIRC	chr12	52949126	5'UTR	rs758566910		0.27
KIRP	chr12	52952637	Intron	novel		0.06
LGG	chr12	52950858	Silent	rs752822458	I203I	0.45
LIHC	chr12	52952141	Missense_Mutation	NA	L324Q	0.4
LIHC	chr12	52949500	Silent	novel	E109E	0.14
LIHC	chr12	52950568	Intron	NA		0.47
LUAD	chr12	52950526	Intron	novel		0.18
LUAD	chr12	52952211	Silent	novel	S347S	0.2
LUAD	chr12	52949111	5'UTR	novel		0.13
LUAD	chr12	52952630	Intron	novel		0.2
LUAD	chr12	52949113	5'UTR	novel		0.16
LUAD	chr12	52950424	Intron	novel		0.18
LUSC	chr12	52951585	Silent	rs145578755	A254A	0.32
LUSC	chr12	52951822	Missense_Mutation	NA	S305F	0.11
LUSC	chr12	52952184	Silent	novel	L338L	0.47
LUSC	chr12	52949097	5'UTR	novel		0.16
OV	chr12	52951760	Silent	novel	T284T	0.06
OV	chr12	52949613	Intron	novel		0.36
OV	chr12	52952696	Intron	rs370618301		0.1
OV	chr12	52952713	Intron	novel		0.09
OV	chr12	52952576	Intron	novel		0.12
OV	chr12	52949121	5'UTR	novel		0.33
OV	chr12	52949115	5'UTR	novel		0.2
PRAD	chr12	52949352	Missense_Mutation	novel	S60Y	0.46
PRAD	chr12	52952638	Intron	novel		0.43
READ	chr12	52950674	Intron	novel		0.57
SKCM	chr12	52950360	Silent	NA	I150I	0.41
SKCM	chr12	52951535	Missense_Mutation	NA	D238N	0.57
SKCM	chr12	52952671	Intron	novel		0.18
SKCM	chr12	52952784	Missense_Mutation	rs146080391	R412Q	0.31
SKCM	chr12	52951844	Silent	NA	S312S	0.34
SKCM	chr12	52951504	Silent	NA	Q227Q	0.98
SKCM	chr12	52950500	Intron	novel		0.24
SKCM	chr12	52949153	5'UTR	NA		0.27
SKCM	chr12	52949256	Missense_Mutation	NA	P28L	0.35
SKCM	chr12	52949604	Intron	novel		0.24
SKCM	chr12	52950561	Intron	novel		0.24
SKCM	chr12	52952214	Silent	NA	E348E	0.44
SKCM	chr12	52951614	Missense_Mutation	rs762129501	R264Q	0.58
SKCM	chr12	52951832	Silent	rs149270992	I308I	0.57
SKCM	chr12	52949411	Missense_Mutation	rs199572098	E80K	0.34
SKCM	chr12	52951507	Missense_Mutation	NA	I228M	0.24
SKCM	chr12	52950460	Intron	novel		0.07
SKCM	chr12	52952850	3'UTR	novel		0.43
SKCM	chr12	52950804	Silent	NA	L185L	0.48
SKCM	chr12	52949554	Silent	novel	S127S	0.86
SKCM	chr12	52949416	Silent	novel	K81K	0.63
SKCM	chr12	52950460	Intron	novel		0.46
SKCM	chr12	52949657	Intron	novel		0.19
STAD	chr12	52952819	Missense_Mutation	NA	D424Y	0.09
STAD	chr12	52951620	Missense_Mutation	novel	E266V	0.09
STAD	chr12	52949396	Missense_Mutation	NA	G75R	0.32
STAD	chr12	52949633	Intron	novel		0.42
STAD	chr12	52950858	Silent	rs752822458	I203I	0.66
STAD	chr12	52952646	Intron	novel		0.11
STAD	chr12	52952697	Intron	novel		0.18
STAD	chr12	52951595	Missense_Mutation	novel	E258K	0.29
STAD	chr12	52949295	Missense_Mutation	novel	G41D	0.37
THCA	chr12	52952254	Missense_Mutation	NA	E362K	0.24
UCEC	chr12	52949591	Splice_Site	NA	X139_splice	0.19
UCEC	chr12	52952568	Intron	novel		0.33
UCEC	chr12	52952599	Intron	novel		0.44
UCEC	chr12	52950874	Missense_Mutation	novel	E209K	0.21
UCEC	chr12	52950853	Nonsense_Mutation	novel	E202*	0.21
UCEC	chr12	52949286	Missense_Mutation	novel	G38D	0.52
UCEC	chr12	52951529	Missense_Mutation	NA	E236K	0.32
UCEC	chr12	52949145	5'UTR	NA		0.16
UCEC	chr12	52949488	Silent	novel	N105N	0.13
UCEC	chr12	52952231	Missense_Mutation	novel	A354V	0.43
UCEC	chr12	52949383	Silent	novel	G70G	0.33
UCEC	chr12	52949149	5'UTR	NA		0.48
UCEC	chr12	52950884	Missense_Mutation	novel	F212S	0.18
UCEC	chr12	52950505	Intron	novel		0.14
UCEC	chr12	52951793	Silent	rs756436730	T295T	0.36
UCS	chr12	52949532	Missense_Mutation	novel	G120E	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1875	0.085003
READ	DEL	0.0667	0.064633
STAD	DEL	0.0952	0.22179

Survival Analysis

Cancer	P-value	Q-value
SARC	0.03	Kaplan-Meier Survival Analysis
ACC	0.03	Kaplan-Meier Survival Analysis
HNSC	0.0065	Kaplan-Meier Survival Analysis
SKCM	0.036	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
PAAD	0.00017	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
GBM	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0059	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000111057 (Gene tree)
Gene ID: 3875
Gene Symbol: KRT18
Alias: N
Full Name: keratin 18
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 4,031 bases
Position: chr12:52,948,871-52,952,901
Accession: 6430
Summary: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21283634	Tumor suppression by RNA from C/EBP-and-beta; 3'UTR through the inhibition of protein kinase C-epsilon activity.	PLoS One	2011 Jan 24	Wang Y	doi: 10.1371/journal.pone.0016543.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549078	KRT18-206	2088	-	-	- (aa)	-	-
ENST00000548496	KRT18-205	695	-	-	- (aa)	-	-
ENST00000388837	KRT18-202	1420	-	ENSP00000373489	430 (aa)	-	P05783
ENST00000388835	KRT18-201	1562	-	ENSP00000373487	430 (aa)	-	P05783
ENST00000550600	KRT18-207	1696	-	ENSP00000447278	391 (aa)	-	F8VZY9
ENST00000546656	KRT18-203	521	-	-	- (aa)	-	-
ENST00000548015	KRT18-204	928	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000111057's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04915	Estrogen signaling pathway	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000111057	Cleft Lip	6E-6	28054174
ENSG00000111057	Cleft Palate	6E-6	28054174
ENSG00000111057	Cleft Lip	4E-12	28232668
ENSG00000111057	Cleft Palate	4E-12	28232668
ENSG00000111057	Cleft Lip	2E-7	28054174
ENSG00000111057	Cleft Palate	2E-7	28054174

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111057's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005515	protein binding	10852826.10954706.11684708.14756564.15671067.15731013.15846844.16189514.19549727.20035625.21988832.23112296.25416956.25910212.26769854.26871637.30021884.	IPI	Function
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	16424149.20346438.	IDA	Component
GO:0005815	microtubule organizing center	18000879.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005882	intermediate filament	10852826.	IDA	Component
GO:0005913	cell-cell adherens junction	25468996.	HDA	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0009653	anatomical structure morphogenesis	2434380.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0031424	keratinization	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	IEA	Process
GO:0034451	centriolar satellite	18000879.	IDA	Component
GO:0043000	Golgi to plasma membrane CFTR protein transport	15529338.	IDA	Process
GO:0043066	negative regulation of apoptotic process	11684708.	IDA	Process
GO:0045095	keratin filament	16424149.	IDA	Component
GO:0045104	intermediate filament cytoskeleton organization	20346438.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0070268	cornification	-	TAS	Process
GO:0071944	cell periphery	-	IEA	Component
GO:0097110	scaffold protein binding	10852826.	IPI	Function
GO:0097191	extrinsic apoptotic signaling pathway	-	IEA	Process
GO:0097284	hepatocyte apoptotic process	-	IEA	Process
GO:0098609	cell-cell adhesion	-	IEA	Process
GO:0098641	cadherin binding involved in cell-cell adhesion	25468996.	HDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.