EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23292607Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells.Oncol Rep2013 MarWang ZGdoi: 10.3892/or.2012.2216
30150608Coronin 1c and F-actin Promote Metastasis of Breast Cancer.Med Sci Monit2018 Aug 28Shao Jdoi: 10.12659/MSM.908929.
22974233Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K.Mol Cancer2012 Sep 14Ren Gdoi: 10.1186/1476-4598-11-67.
28302118YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro.BMC Cancer2017 Mar 16Lim JPdoi: 10.1186/s12885-017-3187-7.
30065298Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.Oncogene2018 DecCastagnino Adoi: 10.1038/s41388-018-0422-x

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr12108662083Frame_Shift_DelnovelK131Efs*360.23
BLCAchr12108658896Missense_MutationNAW158G0.25
BLCAchr12108678289Missense_MutationnovelE101K0.24
BLCAchr12108648820Missense_MutationnovelD364N0.49
BLCAchr12108701311Missense_MutationNAR3P0.34
BLCAchr12108658749Missense_MutationnovelE207Q0.21
BLCAchr12108701288Missense_MutationNAR11W0.06
BRCAchr12108657410Missense_MutationNAA215V0.29
BRCAchr121086473373'UTRnovel0.29
BRCAchr12108648746Missense_MutationNAI388M0.23
BRCAchr12108657340SilentnovelS238S1
BRCAchr12108647456Missense_MutationNAQ458E0.12
BRCAchr12108662132SilentNAL115L0.15
BRCAchr12108678375Missense_MutationNAS72C0.23
CESCchr12108648799Missense_Mutationrs762661543A371T0.38
CESCchr12108657369Missense_MutationNAD229N0.08
CESCchr12108702891Intronnovel0.41
CESCchr12108657423Missense_MutationNAE211K0.14
CESCchr12108702888Intronnovel0.13
COADchr12108647446Missense_MutationNAR461H0.13
COADchr12108678387Missense_MutationNAR68Q0.41
COADchr12108658772Missense_MutationnovelR199K0.22
COADchr121086473743'UTRnovel0.39
COADchr121086472653'UTRrs5589053440.28
COADchr121086472593'UTRnovel0.18
COADchr12108701170Missense_MutationNAI50T0.16
GBMchr12108647440Missense_MutationnovelS463Y0.05
GBMchr12108654370Missense_MutationnovelT264S0.06
GBMchr121086472683'UTRnovel0.11
HNSCchr12108657331Missense_MutationnovelS241R0.12
HNSCchr12108657369Missense_MutationNAD229N0.4
HNSCchr12108657304Splice_Regionrs762555895P250P0.18
LGGchr12108701288Missense_MutationNAR11W0.1
LIHCchr12108657306Missense_MutationnovelP250T0.29
LIHCchr12108657307Missense_MutationnovelN249K0.29
LUADchr12108648697Missense_MutationNAV405F0.07
LUADchr12108657369Missense_MutationNAD229N0.17
LUADchr12108658892Frame_Shift_DelnovelN153Mfs*90.19
LUADchr12108652331Missense_MutationNAQ314H0.1
LUADchr12108658737Splice_SitenovelX210_splice0.28
LUADchr12108658739Missense_MutationnovelA210V0.28
LUADchr12108701121Splice_Regionnovel0.12
LUADchr12108662156Splice_RegionNAV107V0.33
LUADchr12108652347Missense_MutationNAS309I0.18
LUADchr12108701169Missense_MutationNAI50M0.27
LUADchr12108658878Nonsense_MutationnovelE164*0.12
LUADchr121086473253'UTRnovel0.07
LUSCchr12108658817Missense_Mutationrs771989893R184Q0.27
LUSCchr12108658855Silentrs755025882D171D0.31
LUSCchr12108648787Missense_MutationNAE375K0.25
LUSCchr12108701282Missense_MutationNAV13L0.18
LUSCchr12108657327Missense_MutationNAR243W0.32
LUSCchr12108648698SilentnovelV404V0.17
OVchr12108648623SilentnovelT429T0.06
READchr12108652369Missense_MutationNAV302I0.26
READchr12108648650SilentnovelC420C0.34
READchr12108648752SilentnovelI386I0.39
READchr12108658866Missense_MutationnovelN168H0.13
SARCchr12108652373Silentrs748283648P300P0.2
SARCchr12108701260Missense_Mutationrs749438076N20S0.63
SKCMchr12108662085Missense_MutationnovelK131T0.19
SKCMchr12108662124Missense_MutationNAS118F0.15
SKCMchr12108647445SilentNAR461R0.4
SKCMchr12108648744Missense_MutationNAS389F0.88
SKCMchr12108648839SilentNAF357F0.28
SKCMchr12108652384Missense_MutationNAD297N0.55
SKCMchr12108652376SilentNAS299S0.08
SKCMchr12108658844Missense_MutationNAD175V0.46
SKCMchr12108652412SilentNAD287D0.35
SKCMchr12108652376SilentNAS299S0.35
STADchr12108648647SilentNAD421D0.19
STADchr12108647438Missense_MutationNAK464E0.34
STADchr12108652369Missense_MutationNAV302I0.35
STADchr12108652319SilentNAG318G0.05
STADchr121086473733'UTRnovel0.43
STADchr121086472593'UTRnovel0.45
STADchr12108701250SilentNAC23C0.34
THCAchr121086473193'UTRnovel0.06
UCECchr12108701262Missense_MutationNAK19N0.34
UCECchr121086472073'UTRnovel0.4
UCECchr12108702868Intronnovel0.25
UCECchr12108702957Intronnovel0.33
UCECchr12108678378Missense_MutationNAK71T0.39
UCECchr12108662078Silentrs760519774V133V0.44
UCECchr12108658858Silentrs768088134D170D0.34
UCECchr12108648767Missense_MutationnovelK381N0.49
UCECchr121086473393'UTRnovel0.29
UCECchr12108701237Missense_MutationnovelR28W0.39
UCECchr121086471913'UTRnovel0.26
UCECchr121086472603'UTRnovel0.31
UCECchr12108678316Missense_MutationNAN92D0.48
UCECchr12108662078Silentrs760519774V133V0.17
UCECchr121086469223'UTRnovel0.88
UCECchr12108652275Missense_MutationNAA333V0.43
UCECchr12108662106Missense_MutationNAV124A0.46
UCECchr12108652403SilentnovelI290I0.35
UCECchr12108658896Missense_MutationnovelW158R0.36
UCECchr121086472073'UTRnovel0.24
UCECchr12108648839Missense_MutationnovelF357L0.38
UCECchr12108652414Missense_MutationnovelD287N0.27
UCECchr121086471903'UTRnovel0.41
UCECchr12108702984Intronrs3742942560.24
UCECchr12108657386Missense_MutationnovelR223I0.44
UCECchr12108652385Silentrs773150683T296T0.38
UCECchr12108647479Missense_MutationnovelS450F0.45
UCECchr12108657302Splice_SitenovelX250_splice0.37
UCECchr12108648776Silentrs375038851F378F0.42
UCECchr12108702984Intronrs3742942560.18
UCECchr12108678387Missense_MutationNAR68Q0.36
UCECchr12108662054SilentnovelT141T0.29
UCECchr12108654405SilentnovelN252N0.41
UCECchr12108662072Silentrs372909353I135I0.38
UCECchr121086472083'UTRnovel0.11
UCECchr12108648776Silentrs375038851F378F0.4
UCECchr121086473773'UTRnovel0.14
UCECchr121086472663'UTRnovel0.28
UCECchr12108678387Missense_MutationNAR68Q0.18
UCECchr12108657369Missense_MutationNAD229N0.33
UCECchr12108658739Missense_MutationnovelA210V0.27
UCECchr12108652271Splice_SiteNAX334_splice0.25
UCECchr12108648772Missense_MutationNAG380C0.23
UCECchr12108662078Silentrs760519774V133V0.35
UCECchr12108702884Intronnovel0.29

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.02220.20414
CHOLDEL0.22220.067545
HNSCDEL0.06130.22646
LUADDEL0.14150.0059643
LUSCDEL0.08980.038823
PAADDEL0.18480.0030251
PRADAMP0.05890.016187
SKCMDEL0.19070.00079981

Survival Analysis
CancerP-value Q-value
ACC0.025

Kaplan-Meier Survival Analysis

HNSC0.0099

Kaplan-Meier Survival Analysis

SKCM0.0044

Kaplan-Meier Survival Analysis

PAAD0.014

Kaplan-Meier Survival Analysis

BLCA0.0016

Kaplan-Meier Survival Analysis

READ0.037

Kaplan-Meier Survival Analysis

LAML0.0022

Kaplan-Meier Survival Analysis

KICH0.041

Kaplan-Meier Survival Analysis

GBM0.01

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.0086

Kaplan-Meier Survival Analysis

LUAD0.025

Kaplan-Meier Survival Analysis

UVM0.00047

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000110880 (Gene tree)
Gene ID
23603
Gene Symbol
CORO1C
Alias
coronin-3|HCRNN4
Full Name
coronin 1C
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
86,488 bases
Position
chr12:108,645,109-108,731,596
Accession
2254
RBP type
non-canonical RBP
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000551550CORO1C-217547-ENSP00000448527163 (aa)-F8VRE9
ENST00000547294CORO1C-208566-ENSP00000449330181 (aa)-F8VVB7
ENST00000552030CORO1C-218547--- (aa)--
ENST00000549772CORO1C-2121710-ENSP00000447534480 (aa)-Q9ULV4
ENST00000547361CORO1C-209683--- (aa)--
ENST00000420959CORO1C-2023921XM_017019121ENSP00000394496527 (aa)XP_016874610Q9ULV4
ENST00000546571CORO1C-205899-ENSP00000448195162 (aa)-F8VSA4
ENST00000541050CORO1C-2042487-ENSP00000438341474 (aa)-Q9ULV4
ENST00000421578CORO1C-2031296-ENSP00000415554369 (aa)-B4E3S0
ENST00000552871CORO1C-219587-ENSP00000449658125 (aa)-F8VV53
ENST00000546705CORO1C-206577-ENSP00000447337165 (aa)-H0YHL7
ENST00000261401CORO1C-2013892XM_017019122ENSP00000261401474 (aa)XP_016874611Q9ULV4
ENST00000551044CORO1C-215567-ENSP00000447049151 (aa)-F8W1H8
ENST00000551059CORO1C-216474--- (aa)--
ENST00000547170CORO1C-207804--- (aa)--
ENST00000549384CORO1C-210891--- (aa)--
ENST00000550542CORO1C-2141245-ENSP00000448130159 (aa)-F8VUX3
ENST00000550032CORO1C-213547-ENSP00000447989169 (aa)-F8VTT6
ENST00000549387CORO1C-211873--- (aa)--
Gene Model
Click here to download ENSG00000110880's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000110880Diabetes Mellitus, Type 23.553878E-517463248
ENSG00000110880Cardiovascular Physiological Phenomena2.2850000E-005-
ENSG00000110880Child Development Disorders, Pervasive9.8000000E-005-
ENSG00000110880Cholesterol, HDL3E-726879886
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000110880rs75013412108667330TLow high density lipoprotein cholesterol levels26879886[1.08-2.33]1.5873016EFO_0004612
ENSG00000110880rs496427312108709897TCognitive performance (MTAG)30038396[0.0081-0.0171] unit decrease0.0126EFO_0008354
ENSG00000110880rs496427312108709897?General cognitive ability29844566z-score decrease5.128EFO_0004337
ENSG00000110880rs374178212108701361ACoronary artery disease and LDL cholesterol levels (multivariate analysis)30525989EFO_0004611|EFO_0000378
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110880's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001755neural crest cell migration25074804.IMPProcess
GO:0001932regulation of protein phosphorylation19913511.IGIProcess
GO:0001933negative regulation of protein phosphorylation19913511.IMPProcess
GO:0005515protein binding25074804.26655834.IPIFunction
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion19913511.IDAComponent
GO:0005938cell cortex-IEAComponent
GO:0006909phagocytosis9778037.TASProcess
GO:0007165signal transduction9778037.TASProcess
GO:0010008endosome membrane30220460.IDAComponent
GO:0010632regulation of epithelial cell migration19913511.IGIProcess
GO:0010633negative regulation of epithelial cell migration19913511.IMPProcess
GO:0010762regulation of fibroblast migration-ISSProcess
GO:0015629actin cytoskeleton22364218.IDAComponent
GO:0016197endosomal transport30220460.IDAProcess
GO:0016328lateral plasma membrane25074804.IDAComponent
GO:0016600flotillin complex-ISSComponent
GO:0030017sarcomere-IEAComponent
GO:0030027lamellipodium22364218.IDAComponent
GO:0030036actin cytoskeleton organization-IEAProcess
GO:0031982vesicle25074804.IDAComponent
GO:0032587ruffle membrane-IEAComponent
GO:0042383sarcolemma-IEAComponent
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation19913511.IMPProcess
GO:0045184establishment of protein localization-ISSProcess
GO:0045202synapse-IEAComponent
GO:0048365Rac GTPase binding-IEAFunction
GO:0051015actin filament binding22364218.IMPFunction
GO:0051893regulation of focal adhesion assembly19913511.IGIProcess
GO:0051895negative regulation of focal adhesion assembly19913511.IMPProcess
GO:0090148membrane fission30220460.IDAProcess
GO:0090630activation of GTPase activity-ISSProcess
GO:0097750endosome membrane tubulation30220460.IDAProcess
GO:1900024regulation of substrate adhesion-dependent cell spreading19913511.IGIProcess
GO:1900025negative regulation of substrate adhesion-dependent cell spreading19913511.IMPProcess
GO:1900027regulation of ruffle assembly-IEAProcess
GO:2000394positive regulation of lamellipodium morphogenesis19913511.IMPProcess
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