EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19676054Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer.Int J Cancer2010 Jan 15Huang Ddoi: 10.1002/ijc.24820.
29479058Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.Oncogene2018 MayOyinlade Odoi: 10.1038/s41388-018-0138-y

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr439510389SilentNAL209L0.08
BLCAchr439505732Missense_MutationnovelD308A0.22
BLCAchr439505733Missense_MutationnovelD308Y0.22
BLCAchr439505266Missense_MutationNAS381F0.14
BLCAchr439510713Missense_MutationnovelE138G0.15
BLCAchr4395000923'UTRnovel0.55
BLCAchr439505289SilentnovelR373R0.21
BRCAchr439503913Missense_MutationNAD446N0.12
CESCchr439505717Missense_MutationnovelR313M0.17
COADchr439503954Frame_Shift_InsnovelM432Nfs*200.29
COADchr439514134Missense_MutationNAF71L0.33
COADchr4395000283'UTRnovel0.53
COADchr4395000383'UTRnovel0.21
COADchr439505298Frame_Shift_DelNAV371Yfs*60.34
COADchr439510708Missense_MutationnovelI140L0.16
COADchr439514133Frame_Shift_Delrs765734647S72Lfs*180.4
COADchr439510729Missense_MutationNAP133S0.44
COADchr439514142Missense_Mutationrs140219602L69I0.11
COADchr4394999823'UTRnovel0.32
ESCAchr4395001363'UTRnovel0.11
ESCAchr439510821Missense_MutationnovelR102L0.09
GBMchr439510783Missense_Mutationrs140504706R115C0.08
GBMchr439514084Missense_MutationnovelS88Y0.2
GBMchr439510760SilentnovelG122G0.06
GBMchr439503959SilentnovelK430K0.05
HNSCchr439505719Missense_MutationnovelR312S0.28
HNSCchr439500217Missense_MutationnovelI471L0.07
HNSCchr439505658Missense_MutationnovelI333F0.19
HNSCchr439510833Missense_MutationnovelM98T0.22
HNSCchr439521472Missense_Mutationrs369608407Y14C0.25
KIRPchr439514133Missense_Mutationrs769243823S72P0.42
LGGchr439508648Missense_MutationnovelS275N0.41
LUADchr439514121Missense_MutationNAD76N0.19
LUADchr439514181Nonsense_MutationNAG56*0.15
LUADchr439505330Missense_MutationNAE360K0.14
LUADchr439510689Missense_MutationNAA146V0.27
LUADchr439510460Missense_MutationNAP186A0.12
LUSCchr439500212SilentnovelP472P0.06
LUSCchr439509794Missense_MutationNAQ259H0.45
LUSCchr439505308Missense_MutationnovelY367C0.26
OVchr439503906Missense_MutationnovelL448R0.21
OVchr439500178Missense_MutationNAL484F0.47
OVchr439509840Missense_MutationnovelT244R0.09
PAADchr439510765Missense_Mutationrs766669367N121D0.31
PAADchr439521401Missense_MutationnovelN38D0.2
PRADchr439509892Missense_MutationnovelL227V0.08
PRADchr439504442Missense_MutationNAI413T0.1
READchr439521398Nonsense_MutationNAE39*0.19
SARCchr439503952Frame_Shift_DelnovelH429*0.17
SARCchr439514158SilentnovelS63S0.34
SARCchr439514159Missense_MutationnovelS63F0.34
SKCMchr439505618Missense_MutationNAR346K0.15
SKCMchr439508611SilentNAL287L0.59
SKCMchr439521459SilentNAP18P0.43
STADchr439503955Frame_Shift_Delrs774133578M432Cfs*20.15
STADchr439503954Frame_Shift_InsnovelM432Nfs*200.22
STADchr439510842Missense_MutationNAT95N0.22
STADchr439505652Missense_MutationnovelG335R0.25
STADchr439521388Missense_MutationnovelI42N0.16
STADchr439503885Missense_Mutationrs755764491I455T0.21
STADchr439510783Missense_Mutationrs140504706R115C0.31
UCECchr439521502Missense_MutationnovelI4N0.29
UCECchr439500232Missense_Mutationrs750080424V466M0.47
UCECchr439508630Missense_MutationnovelV281G0.38
UCECchr439514181Nonsense_MutationNAG56*0.35
UCECchr439521413Missense_MutationnovelV34I0.09
UCECchr439509884Missense_MutationnovelQ229H0.06
UCECchr439510384Missense_Mutationrs770721281T211N0.07
UCECchr439510666Missense_MutationnovelL154V0.11
UCECchr439505302Missense_MutationnovelP369L0.3
UCECchr439503921Missense_MutationNAR443H0.29
UCECchr439510723Missense_Mutationrs768674438R135W0.47
UCECchr439514103Missense_MutationnovelA82T0.32
UCECchr439514172Missense_MutationnovelE59K0.33
UCECchr439504435SilentNAT415T0.31
UCECchr439514106Nonsense_MutationnovelE81*0.41
UCECchr439521373Missense_MutationnovelS47Y0.57
UCECchr439504430Missense_MutationnovelW417L0.39
UCECchr439521495Missense_MutationnovelK6N0.41
UCECchr439514132Missense_MutationnovelS72Y0.34
UCECchr4395001283'UTRnovel0.13
UCECchr439514133Frame_Shift_Delrs765734647S72Lfs*180.41
UCECchr439510705Missense_Mutationrs115137663R141C0.53
UCECchr439503955Frame_Shift_Delrs774133578M432Cfs*20.48
UCECchr439521398Nonsense_MutationNAE39*0.38
UCECchr439521468SilentnovelV15V0.14
UCECchr439500219Missense_MutationnovelR470I0.33
UCECchr439521474SilentNAG13G0.29
UCECchr439504429Missense_MutationnovelW417C0.34
UCECchr439510701Missense_Mutationrs368044471R142H0.34
UCSchr439505302Missense_MutationnovelP369R0.25

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LIHCAMP0.12970.0362
READDEL0.33330.14076

Survival Analysis
CancerP-value Q-value
ACC0.0033

Kaplan-Meier Survival Analysis

SKCM0.028

Kaplan-Meier Survival Analysis

BRCA0.01

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

PAAD0.0067

Kaplan-Meier Survival Analysis

LAML0.0031

Kaplan-Meier Survival Analysis

LIHC0.0063

Kaplan-Meier Survival Analysis

LUAD0.015

Kaplan-Meier Survival Analysis

UVM0.028

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000109814 (Gene tree)
Gene ID
7358
Gene Symbol
UGDH
Alias
N
Full Name
UDP-glucose 6-dehydrogenase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
29,557 bases
Position
chr4:39,498,755-39,528,311
Accession
12525
RBP type
non-canonical RBP
Summary
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23137539Rossmann-fold motifs can confer multiple functions to metabolic enzymes: RNA binding and ribonuclease activity of a UDP-glucose dehydrogenase.Biochem Biophys Res Commun2013 Jan 4Barbas Adoi: 10.1016/j.bbrc.2012.10.091
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000514106UGDH-210568-ENSP00000425834153 (aa)-E7ETF4
ENST00000316423UGDH-2013216XM_005262667ENSP00000319501494 (aa)XP_005262724O60701
ENST00000501493UGDH-2022826-ENSP00000422909427 (aa)-O60701
ENST00000510881UGDH-209549-ENSP0000042405955 (aa)-E9PBD2
ENST00000515398UGDH-212584--- (aa)--
ENST00000503779UGDH-203575-ENSP0000042443555 (aa)-E9PBD2
ENST00000507089UGDH-2061712-ENSP00000426560397 (aa)-O60701
ENST00000515021UGDH-211861-ENSP00000421954181 (aa)-E7EV97
ENST00000505698UGDH-204433-ENSP0000042256584 (aa)-E7ER95
ENST00000510490UGDH-208534-ENSP0000042770853 (aa)-D6RHF4
ENST00000509391UGDH-207577-ENSP00000422603130 (aa)-E7ER83
ENST00000506179UGDH-2053021-ENSP00000421757494 (aa)-O60701
Gene Model
Click here to download ENSG00000109814's gene model file
Pathways
Pathway IDPathway NameSource
hsa00040Pentose and glucuronate interconversionsKEGG
hsa00053Ascorbate and aldarate metabolismKEGG
hsa00520Amino sugar and nucleotide sugar metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000109814Platelet Function Tests2.9673700E-005-
ENSG00000109814Platelet Function Tests2.9673700E-005-
ENSG00000109814Platelet Function Tests2.8331100E-005-
ENSG00000109814Platelet Function Tests2.1238000E-005-
ENSG00000109814Platelet Function Tests3.5690800E-005-
ENSG00000109814Platelet Function Tests3.5690800E-005-
ENSG00000109814Platelet Function Tests3.3300400E-005-
ENSG00000109814Platelet Function Tests2.8975700E-005-
ENSG00000109814Autistic Disorder9.0510000E-006-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000109814rs56118664439516245GAnkle injury289573841.8994EFO_1002021
ENSG00000109814rs3755899439528080GPeripheral arterial disease (traffic-related air pollution interaction)27082954[1772.72-1806.94]1789.83EFO_0004265|EFO_0007908
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109814's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000109814UGDH9864.062WBGene00005022sqv-49565.659Caenorhabditis_elegans
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001702gastrulation with mouth forming second-ISSProcess
GO:0003979UDP-glucose 6-dehydrogenase activity27966912.IDAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0005975carbohydrate metabolic process-IEAProcess
GO:0006024glycosaminoglycan biosynthetic process21873635.IBAProcess
GO:0006065UDP-glucuronate biosynthetic process27966912.IDAProcess
GO:0006065UDP-glucuronate biosynthetic process-IEAProcess
GO:0006065UDP-glucuronate biosynthetic process-TASProcess
GO:0015012heparan sulfate proteoglycan biosynthetic process-ISSProcess
GO:0030206chondroitin sulfate biosynthetic process-ISSProcess
GO:0034214protein hexamerization27966912.IDAProcess
GO:0051287NAD binding-IEAFunction
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome23533145.HDAComponent
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