EuRBPDB

Ensembl ID

ENSG00000109339 (Gene tree)

Gene ID

5602

Gene Symbol

MAPK10

Alias

JNK3|p493F12|p54bSAPK|PRKM10

Full Name

mitogen-activated protein kinase 10

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Minus strand

Length

604,619 bases

Position

chr4:85,990,007-86,594,625

Accession

6872

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]