EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17332506The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.Mol Biol Cell2007 MayCardone RA-
22622406The detection of EBP50 expression using quantum dot immunohistochemistry in pancreatic cancer tissue and down-regulated EBP50 effect on PC-2 cells.J Mol Histol2012 OctJi MYdoi: 10.1007/s10735-012-9424-0
25756512PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism.Cancer Biol Ther2015Li Ndoi: 10.1080/15384047.2014.1002353.
15467753NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer.Oncogene2004 Nov 11Dai JL-
20736378Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.Cancer Res2010 Sep 1Molina JRdoi: 10.1158/0008-5472.CAN-10-1271
21804599PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.Oncogene2012 Mar 8Molina JRdoi: 10.1038/onc.2011.324
21822312Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells.Oncogene2012 Mar 15Clap??ron Adoi: 10.1038/onc.2011.334
22476347EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation.Amino Acids2012 NovYao Wdoi: 10.1007/s00726-012-1277-z
21707710Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour.Histopathology2011 JunBellizzi Adoi: 10.1111/j.1365-2559.2011.03844.x.
28739728Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50) Suppresses the Metastasis of Breast Cancer and HeLa Cells by Inhibiting Matrix Metalloproteinase-2 Activity.Anticancer Res2017 AugWang L-
29551770β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.Oncogene2018 JunSaponaro Cdoi: 10.1038/s41388-018-0170-y
20012548EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity.Amino Acids2010 AprZheng JFdoi: 10.1007/s00726-009-0437-2
24201803Nuclear NHERF1 expression as a prognostic marker in breast cancer.Cell Death Dis2013 Nov 7Paradiso Adoi: 10.1038/cddis.2013.439.
24012959Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling.FEBS Lett2013 Oct 11Cheng Sdoi: 10.1016/j.febslet.2013.08.026
22366766EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways.Mol Med Rep2012 MayLv XGdoi: 10.3892/mmr.2012.805
26126066The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy.Cancer Biol Ther2015Mangia Adoi: 10.1080/15384047.2015.1056414
26218645SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells.Autophagy2015Liu Hdoi: 10.1080/15548627.2015.1074372.
22440733Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype.Exp Mol Pathol2012 JunMalfettone Adoi: 10.1016/j.yexmp.2012.03.004
12830000EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.Hepatology2003 JulShibata T-
21496870Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers.Hum Pathol2011 NovMangia Adoi: 10.1016/j.humpath.2011.01.010
21170265NHERF1/EBP50 is a new marker in colorectal cancer.Neoplasia2010 DecHayashi Y-
17593079Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancer.Histopathology2007 JulSong J-
26977012A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.Anticancer Res2016 MarDU G-
27823775Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas.Acta Histochem2016 OctDemacopulo Bdoi: 10.1016/j.acthis.2016.10.002
28011475A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.Anticancer Res2017 JanYang X-
27509846EBP50 interacts with EGFR and regulates EGFR signaling to affect the prognosis of cervical cancer patients.Int J Oncol2016 OctPeng Zdoi: 10.3892/ijo.2016.3655
28739734NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition.Anticancer Res2017 AugYang F-
28068322Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.Oncogene2017 Jun 1Vaquero Jdoi: 10.1038/onc.2016.462
27097111The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer.Oncotarget2016 May 17Du Gdoi: 10.18632/oncotarget.8751.
27448983NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer.Oncotarget2016 Aug 23Meng Rdoi: 10.18632/oncotarget.10713.
27999191NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway.Oncotarget2017 Jan 31Gu Ydoi: 10.18632/oncotarget.13949.
28684865Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.Exp Mol Med2017 Jul 7Oh YSdoi: 10.1038/emm.2017.88.
28535016NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling.Oncol Rep2017 JulWang Ydoi: 10.3892/or.2017.5649
29901158Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.Oncol Rep2018 AugGuo Ydoi: 10.3892/or.2018.6494

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1774762150Missense_Mutationrs766158601R194W0.26
BRCAchr17747686713'UTRnovel0.96
BRCAchr1774762162Missense_MutationnovelR198G0.21
BRCAchr1774768652Missense_MutationNAL358P0.25
BRCAchr1774762130Missense_Mutationrs775971197P187R0.49
CESCchr1774762056SilentnovelS162S0.49
COADchr1774763366Splice_Siters767006091X202_splice0.28
COADchr1774768518SilentnovelS313S0.24
COADchr1774768530Silentrs762102314S317S0.41
COADchr1774762118Missense_MutationNAD183V0.09
ESCAchr1774762097Missense_MutationnovelG176A0.18
ESCAchr1774768490Missense_MutationnovelP304R0.65
GBMchr1774766950Missense_MutationnovelP258T0.08
HNSCchr1774768604Missense_Mutationrs773559482R342Q0.27
KIRPchr1774749147Nonsense_MutationNAK101*0.5
LIHCchr17747486465'UTRnovel0.38
LUADchr1774763420SilentNAI219I0.29
LUSCchr1774763373Missense_Mutationrs778705591G204R0.14
LUSCchr1774768195Missense_MutationnovelP283T0.63
MESOchr1774766950Frame_Shift_DelnovelF259Sfs*280.16
OVchr1774768230Frame_Shift_DelnovelS294Rfs*40.08
PAADchr1774766943SilentnovelL255L0.24
PAADchr1774768226Missense_MutationnovelT293I0.2
SKCMchr1774763451Missense_MutationNAV230M0.65
SKCMchr1774768609Missense_MutationNAP344S0.18
SKCMchr17747686923'UTRnovel0.4
STADchr17747687023'UTRnovel0.16
STADchr1774749049In_Frame_DelnovelK69del0.26
STADchr1774768509Silentrs758266041A310A0.25
STADchr1774763375SilentnovelG204G0.44
THCAchr1774763414SilentNAS217S0.35
UCECchr1774763429Silentrs571602239G222G0.35
UCECchr17747686583'UTRnovel0.4
UCECchr17747687903'UTRnovel0.63
UCECchr1774763435Silentrs35833270D224D0.13
UCECchr1774766944Missense_MutationnovelP256S0.28
UCECchr1774766960Missense_MutationNAN261S0.67
UCECchr1774763372SilentnovelN203N0.38
UCECchr1774768230Frame_Shift_DelnovelS294Rfs*40.06
UCECchr1774763459SilentnovelD232D0.05
UCECchr1774762014Splice_Regionrs146791449R148R0.3
UCECchr1774762024Missense_MutationNAP152S0.23
UCECchr1774763387Missense_MutationnovelE208D0.32
UCECchr17747686593'UTRrs2012939820.4
UCECchr1774766967Missense_MutationnovelE263D0.46
UCECchr1774763487Missense_MutationnovelC242R0.47

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.39220.00012456
KIRPAMP0.67010.14801
LGGAMP0.06631.52e-05
LUSCAMP0.35330.001059
SARCAMP0.23740.032181
SKCMAMP0.29437.0388e-08
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
THYM0.035

Kaplan-Meier Survival Analysis

KIRC0.026

Kaplan-Meier Survival Analysis

STAD0.033

Kaplan-Meier Survival Analysis

MESO0.00013

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

LUSC0.0068

Kaplan-Meier Survival Analysis

KIRP0.023

Kaplan-Meier Survival Analysis

COAD0.015

Kaplan-Meier Survival Analysis

PCPG0.018

Kaplan-Meier Survival Analysis

BLCA0.017

Kaplan-Meier Survival Analysis

CESC0.019

Kaplan-Meier Survival Analysis

LAML0.034

Kaplan-Meier Survival Analysis

LIHC0.00014

Kaplan-Meier Survival Analysis

UVM0.00014

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000109062 (Gene tree)
Gene ID
9368
Gene Symbol
SLC9A3R1
Alias
NHERF|EBP50|NHERF1
Full Name
SLC9A3 regulator 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
20,749 bases
Position
chr17:74,748,612-74,769,360
Accession
11075
RBP type
non-canonical RBP
Summary
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000578958SLC9A3R1-203714--- (aa)--
ENST00000262613SLC9A3R1-2011969-ENSP00000262613358 (aa)-O14745
ENST00000413388SLC9A3R1-2021285-ENSP00000464982202 (aa)-O14745
ENST00000583369SLC9A3R1-205841-ENSP00000464321215 (aa)-J3QRP6
ENST00000581356SLC9A3R1-204519-ENSP0000046411735 (aa)-J3QRA3
Gene Model
Click here to download ENSG00000109062's gene model file
Pathways
Pathway IDPathway NameSource
hsa04530Tight junctionKEGG
hsa04928Parathyroid hormone synthesis, secretion and actionKEGG
hsa05165Human papillomavirus infectionKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000109062rs80642991774766507AMonocyte count27863252[0.023-0.037] unit decrease0.03031678EFO_0005091
ENSG00000109062rs126031941774758785AMonocyte percentage of white cells27863252[0.015-0.03] unit decrease0.02250925EFO_0007989
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109062's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001726ruffle-IEAComponent
GO:0003096renal sodium ion transport-IEAProcess
GO:0005102signaling receptor binding16456542.IPIFunction
GO:0005515protein binding9430655.9671706.11285285.12444019.12471024.15020681.15523054.16456542.16615918.17110338.17242191.17244609.17895247.17911601.19027007.19555689.19615732.20395446.20442317.21804599.22506049.23397142.23414517.24012959.29568061.IPIFunction
GO:0005634nucleus17895247.IDAComponent
GO:0005737cytoplasm17895247.20736378.IDAComponent
GO:0005902microvillus17242191.IDAComponent
GO:0007097nuclear migration24862762.IMPProcess
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway-IEAProcess
GO:0007605sensory perception of sound-IEAProcess
GO:0008013beta-catenin binding17242191.IPIFunction
GO:0008285negative regulation of cell proliferation20012548.IDAProcess
GO:0008285negative regulation of cell proliferation20736378.IMPProcess
GO:0008360regulation of cell shape24862762.IMPProcess
GO:0008361regulation of cell size24862762.IMPProcess
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-ISSProcess
GO:0012505endomembrane system-IEAComponent
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling-ISSProcess
GO:0015629actin cytoskeleton9430655.TASComponent
GO:0016020membrane20736378.IDAComponent
GO:0016055Wnt signaling pathway-IEAProcess
GO:0016324apical plasma membrane24862762.IDAComponent
GO:0017081chloride channel regulator activity12881487.IDAFunction
GO:0019902phosphatase binding16456542.IPIFunction
GO:0022612gland morphogenesis24862762.IMPProcess
GO:0030033microvillus assembly20937695.IMPProcess
GO:0030036actin cytoskeleton organization-IEAProcess
GO:0030165PDZ domain binding16236806.IPIFunction
GO:0030175filopodium-IEAComponent
GO:0030336negative regulation of cell migration-IEAProcess
GO:0030643cellular phosphate ion homeostasis-IEAProcess
GO:0031526brush border membrane-IEAComponent
GO:0031528microvillus membrane-ISSComponent
GO:0031698beta-2 adrenergic receptor binding9560162.IPIFunction
GO:0031982vesicle19190083.HDAComponent
GO:0032415regulation of sodium:proton antiporter activity9560162.NASProcess
GO:0032416negative regulation of sodium:proton antiporter activity-IEAProcess
GO:0032426stereocilium tip-IEAComponent
GO:0032782bile acid secretion-ISSProcess
GO:0034635glutathione transport-ISSProcess
GO:0034767positive regulation of ion transmembrane transport-IEAProcess
GO:0043621protein self-association17242191.IDAFunction
GO:0044062regulation of excretion-IEAProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0045121membrane raft-IEAComponent
GO:0045159myosin II binding-IEAFunction
GO:0045198establishment of epithelial cell apical/basal polarity24862762.IMPProcess
GO:0045859regulation of protein kinase activity-ISSProcess
GO:0045930negative regulation of mitotic cell cycle24862762.IMPProcess
GO:0047485protein N-terminus binding-IEAFunction
GO:0048471perinuclear region of cytoplasm24862762.IDAComponent
GO:0050780dopamine receptor binding-IEAFunction
GO:0051683establishment of Golgi localization24862762.IMPProcess
GO:0051898negative regulation of protein kinase B signaling20736378.IMPProcess
GO:0060088auditory receptor cell stereocilium organization-IEAProcess
GO:0060090molecular adaptor activity-IEAFunction
GO:0060158phospholipase C-activating dopamine receptor signaling pathway-IEAProcess
GO:0065003protein-containing complex assembly9430655.TASProcess
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0070293renal absorption-ISSProcess
GO:0070373negative regulation of ERK1 and ERK2 cascade20012548.IDAProcess
GO:0070851growth factor receptor binding17242191.IPIFunction
GO:0071944cell periphery17895247.IDAComponent
GO:0072659protein localization to plasma membrane24862762.IMPProcess
GO:0090090negative regulation of canonical Wnt signaling pathway24862762.IMPProcess
GO:0097225sperm midpiece-ISSComponent
GO:0097291renal phosphate ion absorption18784102.IMPProcess
GO:2001244positive regulation of intrinsic apoptotic signaling pathway20012548.IDAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us