EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17332506	The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.	Mol Biol Cell	2007 May	Cardone RA	-
22622406	The detection of EBP50 expression using quantum dot immunohistochemistry in pancreatic cancer tissue and down-regulated EBP50 effect on PC-2 cells.	J Mol Histol	2012 Oct	Ji MY	doi: 10.1007/s10735-012-9424-0
25756512	PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism.	Cancer Biol Ther	2015	Li N	doi: 10.1080/15384047.2014.1002353.
15467753	NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer.	Oncogene	2004 Nov 11	Dai JL	-
20736378	Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.	Cancer Res	2010 Sep 1	Molina JR	doi: 10.1158/0008-5472.CAN-10-1271
21804599	PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.	Oncogene	2012 Mar 8	Molina JR	doi: 10.1038/onc.2011.324
21822312	Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells.	Oncogene	2012 Mar 15	Clap??ron A	doi: 10.1038/onc.2011.334
22476347	EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation.	Amino Acids	2012 Nov	Yao W	doi: 10.1007/s00726-012-1277-z
21707710	Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour.	Histopathology	2011 Jun	Bellizzi A	doi: 10.1111/j.1365-2559.2011.03844.x.
28739728	Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50) Suppresses the Metastasis of Breast Cancer and HeLa Cells by Inhibiting Matrix Metalloproteinase-2 Activity.	Anticancer Res	2017 Aug	Wang L	-
29551770	β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.	Oncogene	2018 Jun	Saponaro C	doi: 10.1038/s41388-018-0170-y
20012548	EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity.	Amino Acids	2010 Apr	Zheng JF	doi: 10.1007/s00726-009-0437-2
24201803	Nuclear NHERF1 expression as a prognostic marker in breast cancer.	Cell Death Dis	2013 Nov 7	Paradiso A	doi: 10.1038/cddis.2013.439.
24012959	Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling.	FEBS Lett	2013 Oct 11	Cheng S	doi: 10.1016/j.febslet.2013.08.026
22366766	EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways.	Mol Med Rep	2012 May	Lv XG	doi: 10.3892/mmr.2012.805
26126066	The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy.	Cancer Biol Ther	2015	Mangia A	doi: 10.1080/15384047.2015.1056414
26218645	SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells.	Autophagy	2015	Liu H	doi: 10.1080/15548627.2015.1074372.
22440733	Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype.	Exp Mol Pathol	2012 Jun	Malfettone A	doi: 10.1016/j.yexmp.2012.03.004
12830000	EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.	Hepatology	2003 Jul	Shibata T	-
21496870	Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers.	Hum Pathol	2011 Nov	Mangia A	doi: 10.1016/j.humpath.2011.01.010
21170265	NHERF1/EBP50 is a new marker in colorectal cancer.	Neoplasia	2010 Dec	Hayashi Y	-
17593079	Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancer.	Histopathology	2007 Jul	Song J	-
26977012	A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.	Anticancer Res	2016 Mar	DU G	-
27823775	Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas.	Acta Histochem	2016 Oct	Demacopulo B	doi: 10.1016/j.acthis.2016.10.002
28011475	A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.	Anticancer Res	2017 Jan	Yang X	-
27509846	EBP50 interacts with EGFR and regulates EGFR signaling to affect the prognosis of cervical cancer patients.	Int J Oncol	2016 Oct	Peng Z	doi: 10.3892/ijo.2016.3655
28739734	NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition.	Anticancer Res	2017 Aug	Yang F	-
28068322	Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.	Oncogene	2017 Jun 1	Vaquero J	doi: 10.1038/onc.2016.462
27097111	The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer.	Oncotarget	2016 May 17	Du G	doi: 10.18632/oncotarget.8751.
27448983	NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer.	Oncotarget	2016 Aug 23	Meng R	doi: 10.18632/oncotarget.10713.
27999191	NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway.	Oncotarget	2017 Jan 31	Gu Y	doi: 10.18632/oncotarget.13949.
28684865	Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.	Exp Mol Med	2017 Jul 7	Oh YS	doi: 10.1038/emm.2017.88.
28535016	NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling.	Oncol Rep	2017 Jul	Wang Y	doi: 10.3892/or.2017.5649
29901158	Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.	Oncol Rep	2018 Aug	Guo Y	doi: 10.3892/or.2018.6494

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	74762150	Missense_Mutation	rs766158601	R194W	0.26
BRCA	chr17	74768671	3'UTR	novel		0.96
BRCA	chr17	74762162	Missense_Mutation	novel	R198G	0.21
BRCA	chr17	74768652	Missense_Mutation	NA	L358P	0.25
BRCA	chr17	74762130	Missense_Mutation	rs775971197	P187R	0.49
CESC	chr17	74762056	Silent	novel	S162S	0.49
COAD	chr17	74763366	Splice_Site	rs767006091	X202_splice	0.28
COAD	chr17	74768518	Silent	novel	S313S	0.24
COAD	chr17	74768530	Silent	rs762102314	S317S	0.41
COAD	chr17	74762118	Missense_Mutation	NA	D183V	0.09
ESCA	chr17	74762097	Missense_Mutation	novel	G176A	0.18
ESCA	chr17	74768490	Missense_Mutation	novel	P304R	0.65
GBM	chr17	74766950	Missense_Mutation	novel	P258T	0.08
HNSC	chr17	74768604	Missense_Mutation	rs773559482	R342Q	0.27
KIRP	chr17	74749147	Nonsense_Mutation	NA	K101*	0.5
LIHC	chr17	74748646	5'UTR	novel		0.38
LUAD	chr17	74763420	Silent	NA	I219I	0.29
LUSC	chr17	74763373	Missense_Mutation	rs778705591	G204R	0.14
LUSC	chr17	74768195	Missense_Mutation	novel	P283T	0.63
MESO	chr17	74766950	Frame_Shift_Del	novel	*F259Sfs28**	0.16
OV	chr17	74768230	Frame_Shift_Del	novel	*S294Rfs4**	0.08
PAAD	chr17	74766943	Silent	novel	L255L	0.24
PAAD	chr17	74768226	Missense_Mutation	novel	T293I	0.2
SKCM	chr17	74763451	Missense_Mutation	NA	V230M	0.65
SKCM	chr17	74768609	Missense_Mutation	NA	P344S	0.18
SKCM	chr17	74768692	3'UTR	novel		0.4
STAD	chr17	74768702	3'UTR	novel		0.16
STAD	chr17	74749049	In_Frame_Del	novel	K69del	0.26
STAD	chr17	74768509	Silent	rs758266041	A310A	0.25
STAD	chr17	74763375	Silent	novel	G204G	0.44
THCA	chr17	74763414	Silent	NA	S217S	0.35
UCEC	chr17	74763429	Silent	rs571602239	G222G	0.35
UCEC	chr17	74768658	3'UTR	novel		0.4
UCEC	chr17	74768790	3'UTR	novel		0.63
UCEC	chr17	74763435	Silent	rs35833270	D224D	0.13
UCEC	chr17	74766944	Missense_Mutation	novel	P256S	0.28
UCEC	chr17	74766960	Missense_Mutation	NA	N261S	0.67
UCEC	chr17	74763372	Silent	novel	N203N	0.38
UCEC	chr17	74768230	Frame_Shift_Del	novel	*S294Rfs4**	0.06
UCEC	chr17	74763459	Silent	novel	D232D	0.05
UCEC	chr17	74762014	Splice_Region	rs146791449	R148R	0.3
UCEC	chr17	74762024	Missense_Mutation	NA	P152S	0.23
UCEC	chr17	74763387	Missense_Mutation	novel	E208D	0.32
UCEC	chr17	74768659	3'UTR	rs201293982		0.4
UCEC	chr17	74766967	Missense_Mutation	novel	E263D	0.46
UCEC	chr17	74763487	Missense_Mutation	novel	C242R	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3922	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
LUSC	AMP	0.3533	0.001059
SARC	AMP	0.2374	0.032181
SKCM	AMP	0.2943	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
THYM	0.035	Kaplan-Meier Survival Analysis
KIRC	0.026	Kaplan-Meier Survival Analysis
STAD	0.033	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
LUSC	0.0068	Kaplan-Meier Survival Analysis
KIRP	0.023	Kaplan-Meier Survival Analysis
COAD	0.015	Kaplan-Meier Survival Analysis
PCPG	0.018	Kaplan-Meier Survival Analysis
BLCA	0.017	Kaplan-Meier Survival Analysis
CESC	0.019	Kaplan-Meier Survival Analysis
LAML	0.034	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
UVM	0.00014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000109062 (Gene tree)
Gene ID: 9368
Gene Symbol: SLC9A3R1
Alias: NHERF|EBP50|NHERF1
Full Name: SLC9A3 regulator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 20,749 bases
Position: chr17:74,748,612-74,769,360
Accession: 11075
RBP type: non-canonical RBP
Summary: This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000578958	SLC9A3R1-203	714	-	-	- (aa)	-	-
ENST00000262613	SLC9A3R1-201	1969	-	ENSP00000262613	358 (aa)	-	O14745
ENST00000413388	SLC9A3R1-202	1285	-	ENSP00000464982	202 (aa)	-	O14745
ENST00000583369	SLC9A3R1-205	841	-	ENSP00000464321	215 (aa)	-	J3QRP6
ENST00000581356	SLC9A3R1-204	519	-	ENSP00000464117	35 (aa)	-	J3QRA3

Gene Model

Click here to download ENSG00000109062's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04928	Parathyroid hormone synthesis, secretion and action	KEGG
hsa05165	Human papillomavirus infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000109062	rs8064299	17	74766507	A	Monocyte count	27863252	[0.023-0.037] unit decrease	0.03031678	EFO_0005091
ENSG00000109062	rs12603194	17	74758785	A	Monocyte percentage of white cells	27863252	[0.015-0.03] unit decrease	0.02250925	EFO_0007989

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109062's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	IEA	Component
GO:0003096	renal sodium ion transport	-	IEA	Process
GO:0005102	signaling receptor binding	16456542.	IPI	Function
GO:0005515	protein binding	9430655.9671706.11285285.12444019.12471024.15020681.15523054.16456542.16615918.17110338.17242191.17244609.17895247.17911601.19027007.19555689.19615732.20395446.20442317.21804599.22506049.23397142.23414517.24012959.29568061.	IPI	Function
GO:0005634	nucleus	17895247.	IDA	Component
GO:0005737	cytoplasm	17895247.20736378.	IDA	Component
GO:0005902	microvillus	17242191.	IDA	Component
GO:0007097	nuclear migration	24862762.	IMP	Process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	-	IEA	Process
GO:0007605	sensory perception of sound	-	IEA	Process
GO:0008013	beta-catenin binding	17242191.	IPI	Function
GO:0008285	negative regulation of cell proliferation	20012548.	IDA	Process
GO:0008285	negative regulation of cell proliferation	20736378.	IMP	Process
GO:0008360	regulation of cell shape	24862762.	IMP	Process
GO:0008361	regulation of cell size	24862762.	IMP	Process
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	-	ISS	Process
GO:0012505	endomembrane system	-	IEA	Component
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	-	ISS	Process
GO:0015629	actin cytoskeleton	9430655.	TAS	Component
GO:0016020	membrane	20736378.	IDA	Component
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016324	apical plasma membrane	24862762.	IDA	Component
GO:0017081	chloride channel regulator activity	12881487.	IDA	Function
GO:0019902	phosphatase binding	16456542.	IPI	Function
GO:0022612	gland morphogenesis	24862762.	IMP	Process
GO:0030033	microvillus assembly	20937695.	IMP	Process
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0030165	PDZ domain binding	16236806.	IPI	Function
GO:0030175	filopodium	-	IEA	Component
GO:0030336	negative regulation of cell migration	-	IEA	Process
GO:0030643	cellular phosphate ion homeostasis	-	IEA	Process
GO:0031526	brush border membrane	-	IEA	Component
GO:0031528	microvillus membrane	-	ISS	Component
GO:0031698	beta-2 adrenergic receptor binding	9560162.	IPI	Function
GO:0031982	vesicle	19190083.	HDA	Component
GO:0032415	regulation of sodium:proton antiporter activity	9560162.	NAS	Process
GO:0032416	negative regulation of sodium:proton antiporter activity	-	IEA	Process
GO:0032426	stereocilium tip	-	IEA	Component
GO:0032782	bile acid secretion	-	ISS	Process
GO:0034635	glutathione transport	-	ISS	Process
GO:0034767	positive regulation of ion transmembrane transport	-	IEA	Process
GO:0043621	protein self-association	17242191.	IDA	Function
GO:0044062	regulation of excretion	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0045159	myosin II binding	-	IEA	Function
GO:0045198	establishment of epithelial cell apical/basal polarity	24862762.	IMP	Process
GO:0045859	regulation of protein kinase activity	-	ISS	Process
GO:0045930	negative regulation of mitotic cell cycle	24862762.	IMP	Process
GO:0047485	protein N-terminus binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	24862762.	IDA	Component
GO:0050780	dopamine receptor binding	-	IEA	Function
GO:0051683	establishment of Golgi localization	24862762.	IMP	Process
GO:0051898	negative regulation of protein kinase B signaling	20736378.	IMP	Process
GO:0060088	auditory receptor cell stereocilium organization	-	IEA	Process
GO:0060090	molecular adaptor activity	-	IEA	Function
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	-	IEA	Process
GO:0065003	protein-containing complex assembly	9430655.	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0070293	renal absorption	-	ISS	Process
GO:0070373	negative regulation of ERK1 and ERK2 cascade	20012548.	IDA	Process
GO:0070851	growth factor receptor binding	17242191.	IPI	Function
GO:0071944	cell periphery	17895247.	IDA	Component
GO:0072659	protein localization to plasma membrane	24862762.	IMP	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	24862762.	IMP	Process
GO:0097225	sperm midpiece	-	ISS	Component
GO:0097291	renal phosphate ion absorption	18784102.	IMP	Process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	20012548.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.