EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26542179The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.Genes Chromosomes Cancer2016 FebGooskens SLdoi: 10.1002/gcc.22320
2348395514-3-3?? overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma.PLoS One2013Liu TAdoi: 10.1371/journal.pone.0057968
26945340Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney.Am J Surg Pathol2016 AugKao YCdoi: 10.1097/PAS.0000000000000629.
24536031Proteomic identification of 14-3-3 as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells.J Orthop Res2014 JunKim KOdoi: 10.1002/jor.22598
22899242RKIP and 14-3-3?? exert an opposite effect on human gastric cancer cells SGC7901 by regulating the ERK/MAPK pathway differently.Dig Dis Sci2013 FebYan Ldoi: 10.1007/s10620-012-2341-y
27863420YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process.Oncotarget2016 Dec 20Leal MFdoi: 10.18632/oncotarget.13381.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1714001765'UTRnovel0.45
BLCAchr171364975Nonsense_MutationnovelK50*0.05
BLCAchr171364976Nonsense_MutationnovelY49*0.05
BLCAchr171361215Missense_MutationnovelY152C0.48
BLCAchr171354328Missense_MutationNAD200H0.31
BRCAchr171361172Silentrs146808095T166T0.4
CESCchr171361172Silentrs146808095T166T0.46
CESCchr1714002095'UTRnovel0.24
CESCchr171361913Missense_MutationNAF120L0.31
CESCchr171361174Missense_MutationnovelT166A0.22
CHOLchr1713447663'UTRnovel0.12
COADchr171400079Missense_Mutationrs777592060A11V0.42
COADchr1714001835'UTRnovel0.43
COADchr171361296Missense_MutationnovelK125T0.21
COADchr171364998Missense_MutationNAR42I0.17
GBMchr171400101Nonsense_MutationNAR4*0.37
HNSCchr171400092Missense_Mutationrs11552915L7V0.17
HNSCchr171354264In_Frame_DelnovelI220del0.09
HNSCchr171361262Silentrs752894008A136A0.08
KIRCchr171365030Frame_Shift_InsnovelG32Qfs*110.05
KIRCchr171365032Missense_MutationnovelA31T0.02
KIRPchr171361928Silentrs758745399G115G0.03
KIRPchr1713454393'UTRnovel0.49
KIRPchr1714001315'UTRrs7670766390.47
KIRPchr1713453863'UTRnovel0.58
LGGchr1714001395'UTRnovel0.91
LIHCchr171361130Missense_MutationNAF180L0.72
LIHCchr1713454303'UTRnovel0.07
LIHCchr171361959Missense_MutationnovelD105G0.08
LUADchr171354343Missense_MutationNAA195T0.19
LUSCchr171400072Silentrs748149659L13L0.5
LUSCchr171354344Missense_MutationnovelL194F0.27
LUSCchr171361907Silentrs779406770Y122Y0.3
OVchr1714001635'UTRnovel0.9
OVchr171364993Missense_MutationNAL44F0.61
OVchr1714001385'UTRnovel0.32
PAADchr1714001665'UTRrs5386107830.22
PAADchr171354337Missense_MutationnovelA197T0.04
PAADchr171361273Missense_MutationnovelA133T0.18
PAADchr171400079Missense_Mutationrs777592060A11V0.37
READchr1714001345'UTRnovel0.25
READchr171361199SilentNAD157D0.45
SKCMchr1713454373'UTRnovel0.27
SKCMchr1713454383'UTRnovel0.26
SKCMchr171361928Silentrs758745399G115G0.39
SKCMchr171361110Missense_MutationNAS187F0.09
SKCMchr171361137Missense_MutationNAS178F0.12
SKCMchr1713453533'UTRnovel0.42
STADchr1714002355'UTRnovel0.27
STADchr171361267Missense_MutationNAF135I0.17
STADchr171354264In_Frame_DelnovelI220del0.08
STADchr171361248Missense_MutationNAR141K0.2
STADchr171361260Missense_MutationnovelT137I0.77
STADchr1713454083'UTRnovel0.46
STADchr171364865SilentNAR86R0.38
THCAchr171361200Missense_MutationNAD157V0.03
UCECchr1714001665'UTRrs5386107830.39
UCECchr171400068Missense_MutationnovelE15K0.53
UCECchr171345478Missense_Mutationrs754262216A246V0.15
UCECchr1713450913'UTRnovel0.42
UCECchr171361926Missense_MutationNAE116V0.47
UCECchr171361985Silentrs767528415I96I0.33
UCECchr1713453443'UTRnovel0.35
UCECchr171354228Nonsense_MutationNAS233*0.4
UCECchr1713448993'UTRnovel0.67
UCECchr1713449383'UTRrs7789224360.55
UCECchr1713451683'UTRrs1120665070.33
UCECchr171361225SilentnovelL149L0.43
UCECchr1713446373'UTRnovel0.37
UCECchr171345458Missense_MutationnovelE253K0.42
UCECchr171364951Missense_MutationnovelA58T0.12
UCECchr1713445873'UTRnovel0.32
UCECchr171365057Splice_RegionnovelE22E0.52
UCECchr1713446083'UTRnovel0.29
UCECchr1713447453'UTRnovel0.33
UCECchr171345498Splice_RegionnovelG239G0.46
UCECchr1714001625'UTRnovel0.41
UCECchr1713445753'UTRrs1449733350.19
UCECchr1713447273'UTRnovel0.29
UCECchr171361172Silentrs146808095T166T0.05
UCECchr1713453693'UTRnovel0.12
UCECchr1713454453'UTRNA0.28
UCECchr1714001785'UTRNA0.29
UCECchr171345464Nonsense_MutationnovelE251*0.23

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.20830.18166
LAMLDEL0.07330.12511
LIHCDEL0.5273.9592e-10
LUADDEL0.44960.00029194
SKCMDEL0.30250.21028
THCADEL0.0160.221

Survival Analysis
CancerP-value Q-value
KIRC0.0011

Kaplan-Meier Survival Analysis

SARC0.0014

Kaplan-Meier Survival Analysis

ACC0.0047

Kaplan-Meier Survival Analysis

HNSC0.03

Kaplan-Meier Survival Analysis

LAML0.019

Kaplan-Meier Survival Analysis

KICH0.01

Kaplan-Meier Survival Analysis

UCEC0.0001

Kaplan-Meier Survival Analysis

LIHC0.044

Kaplan-Meier Survival Analysis

LGG0.0002

Kaplan-Meier Survival Analysis

CHOL0.024

Kaplan-Meier Survival Analysis

LUAD0.019

Kaplan-Meier Survival Analysis

UVM0.018

Kaplan-Meier Survival Analysis

OV0.046

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000108953 (Gene tree)
Gene ID
7531
Gene Symbol
YWHAE
Alias
FLJ45465
Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
56,107 bases
Position
chr17:1,344,272-1,400,378
Accession
12851
RBP type
non-canonical RBP
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30718516Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control.Nat Commun2019 Feb 4Winz MLdoi: 10.1038/s41467-019-08382-z.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000498643YWHAE-207312--- (aa)--
ENST00000496706YWHAE-206732-ENSP00000466324115 (aa)-K7EM20
ENST00000469398YWHAE-203676--- (aa)--
ENST00000575977YWHAE-212540-ENSP00000460712107 (aa)-I3L3T1
ENST00000576854YWHAE-2131374--- (aa)--
ENST00000466227YWHAE-2021377-ENSP00000464883109 (aa)-K7EIT4
ENST00000571732YWHAE-2081818XM_017025005ENSP00000461762233 (aa)XP_016880494P62258
ENST00000573026YWHAE-210780-ENSP0000045838638 (aa)-I3L0W5
ENST00000489287YWHAE-205465--- (aa)--
ENST00000572108YWHAE-209258--- (aa)--
ENST00000486241YWHAE-204691--- (aa)--
ENST00000264335YWHAE-2012211XM_005256784ENSP00000264335255 (aa)XP_005256841P62258
ENST00000573196YWHAE-211739-ENSP0000046176694 (aa)-B4DJF2
Gene Model
Click here to download ENSG00000108953's gene model file
Pathways
Pathway IDPathway NameSource
hsa04110Cell cycleKEGG
hsa04114Oocyte meiosisKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04390Hippo signaling pathwayKEGG
hsa04722Neurotrophin signaling pathwayKEGG
hsa05160Hepatitis CKEGG
hsa05203Viral carcinogenesisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000108953Platelet Count7.552e-005-
ENSG00000108953Breast Density6.9046861E-006-
ENSG00000108953Breast Density1.3327706E-005-
ENSG00000108953Schizophrenia3E-626198764
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000108953rs9908552171394697TSchizophrenia26198764[NR]1.05EFO_0000692
ENSG00000108953rs56007784171387656CSchizophrenia28991256[1.04-1.08]1.059EFO_0000692
ENSG00000108953rs75543711171352780?Reaction time29844566[0.0061-0.0128] unit decrease0.009456EFO_0008393
ENSG00000108953rs56007784171387656CSchizophrenia30285260[1.03-1.07]1.052EFO_0000692
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108953's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000108953YWHAE9971.930ENSG00000170027YWHAG10063.968Homo_sapiens
ENSG00000108953YWHAE10069.565ENSG00000128245YWHAH9963.265Homo_sapiens
ENSG00000108953YWHAE100100.000ENSMUSG00000020849Ywhae100100.000Mus_musculus
ENSG00000108953YWHAE9971.930ENSMUSG00000051391Ywhag10063.968Mus_musculus
ENSG00000108953YWHAE10069.565ENSMUSG00000018965Ywhah9963.265Mus_musculus
ENSG00000108953YWHAE9683.636YDR099WBMH29373.913Saccharomyces_cerevisiae
ENSG00000108953YWHAE9684.545YER177WBMH19275.203Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-TASProcess
GO:0000165MAPK cascade12917326.IDAProcess
GO:0001764neuron migration-IEAProcess
GO:0003064regulation of heart rate by hormone11953308.NASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005246calcium channel regulator activity18029012.IDAFunction
GO:0005515protein binding1266503.7644510.10644344.11504882.11697890.12392720.12917326.14743216.15722337.16099986.16227609.16260042.16376338.16407301.16511560.16775625.17085597.18045992.18227151.18356162.18458160.18573912.19172738.19640509.20618440.20642453.20936779.21044950.21242966.21282530.21346153.21988832.22151054.22246185.23075850.23572552.23622247.23752268.24255178.24366813.24725412.24947832.25588844.25751139.25852190.26496610.27173435.29128334.29769719.30611118.IPIFunction
GO:0005634nucleus12917326.IDAComponent
GO:0005737cytoplasm12917326.IDAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005829cytosol-TASComponent
GO:0005871kinesin complex-IEAComponent
GO:0005886plasma membrane18029012.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006605protein targeting-IEAProcess
GO:0010389regulation of G2/M transition of mitotic cell cycle-TASProcess
GO:0015459potassium channel regulator activity11953308.IDAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016032viral process-IEAProcess
GO:0019899enzyme binding10788521.IPIFunction
GO:0019904protein domain specific binding-IEAFunction
GO:0021762substantia nigra development22926577.HEPProcess
GO:0021766hippocampus development-IEAProcess
GO:0021987cerebral cortex development-IEAProcess
GO:0023026MHC class II protein complex binding20458337.HDAFunction
GO:0031625ubiquitin protein ligase binding19725078.IPIFunction
GO:0034504protein localization to nucleus29769719.IMPProcess
GO:0034605cellular response to heat12917326.IDAProcess
GO:0035329hippo signaling-TASProcess
GO:0035556intracellular signal transduction7644510.TASProcess
GO:0042470melanosome-IEAComponent
GO:0042802identical protein binding17085597.20936779.IPIFunction
GO:0042826histone deacetylase binding10869435.IPIFunction
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-TASProcess
GO:0044325ion channel binding11953308.18029012.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0046827positive regulation of protein export from nucleus12917326.IDAProcess
GO:0046982protein heterodimerization activity11953308.IPIFunction
GO:0050815phosphoserine residue binding10869435.IPIFunction
GO:0051219phosphoprotein binding10869435.IPIFunction
GO:0051480regulation of cytosolic calcium ion concentration18029012.IDAProcess
GO:0060306regulation of membrane repolarization11953308.IDAProcess
GO:0061024membrane organization-TASProcess
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0086013membrane repolarization during cardiac muscle cell action potential11953308.ICProcess
GO:0086091regulation of heart rate by cardiac conduction11953308.ICProcess
GO:0090724central region of growth cone-IEAComponent
GO:0097110scaffold protein binding10409742.IPIFunction
GO:0097711ciliary basal body-plasma membrane docking-TASProcess
GO:0098978glutamatergic synapse-IEAComponent
GO:0099072regulation of postsynaptic membrane neurotransmitter receptor levels-IEAProcess
GO:1900034regulation of cellular response to heat-TASProcess
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TASProcess
GO:1901016regulation of potassium ion transmembrane transporter activity11953308.IDAProcess
GO:1901020negative regulation of calcium ion transmembrane transporter activity18029012.IDAProcess
GO:1902309negative regulation of peptidyl-serine dephosphorylation11953308.IDAProcess
GO:1905913negative regulation of calcium ion export across plasma membrane18029012.IDAProcess
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