EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28927426The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis.J Exp Clin Cancer Res2017 Sep 19Zhou ZHdoi: 10.1186/s13046-017-0599-9.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1733291434Intronnovel0.14
ACCchr1733291848Intronnovel0.29
BLCAchr1733088908SilentnovelG263G0.25
BLCAchr1733017607Missense_MutationNAE456Q0.37
BLCAchr1734156392SilentnovelV47V0.17
BLCAchr1734156130Missense_MutationNAE135K0.18
BLCAchr1734156145Missense_MutationnovelD130Y0.36
BLCAchr1733024007SilentNAL350L0.56
BLCAchr1733023868Missense_MutationnovelY397H0.06
BLCAchr1733291678Intronnovel0.2
BLCAchr1733291749Intronnovel0.44
BLCAchr1733023860Splice_SitenovelX399_splice0.38
BLCAchr1733291614Intronnovel0.38
BRCAchr1733013971SilentnovelA511A0.11
BRCAchr1733112010SilentNAL205L0.16
BRCAchr1733088866SilentNAQ277Q0.31
BRCAchr1734156385Missense_Mutationrs753583147V50M0.44
BRCAchr1733014013Silentrs200452478N497N0.19
BRCAchr1733088897Missense_Mutationrs745617613G267E0.5
CESCchr1734156445Missense_MutationNAR30C0.35
CESCchr1734156444Missense_MutationNAR30H0.44
CESCchr1734156349Missense_MutationnovelE62K0.35
CESCchr1733291553Intronnovel0.15
CESCchr1733291934Intronnovel0.33
CESCchr1733023965Nonsense_MutationnovelC364*0.32
CESCchr1733291576Intronnovel0.19
CESCchr1733111944Missense_MutationNAE227K0.37
CESCchr1733013999Missense_Mutationrs201100877T502M0.25
COADchr17341566225'UTRnovel0.13
COADchr1733017625Missense_MutationNAL450F0.24
COADchr17341566465'UTRnovel0.3
COADchr1734156367SilentNAL56L0.22
COADchr1733088984Missense_Mutationrs147403420T238M0.32
COADchr1733017611Missense_MutationnovelI454M0.19
COADchr1734156120Missense_Mutationrs754954730R138Q0.31
COADchr1733028245Missense_MutationnovelP328S0.13
COADchr1733021272Missense_MutationnovelL412R0.41
COADchr1733028259Missense_MutationNAR323H0.33
COADchr1733111987Frame_Shift_DelNAT213Qfs*320.35
COADchr1733111986Frame_Shift_InsNAT213Dfs*150.38
COADchr1733088958In_Frame_InsnovelV246_Q247insG0.06
COADchr1733088960Missense_MutationnovelV246D0.06
COADchr1733023999Frame_Shift_DelNAK353Rfs*140.38
COADchr1734156403SilentNAL44L0.29
COADchr1733021242Missense_MutationNAA422V0.15
COADchr1734156336Missense_Mutationrs201229528Y66C0.16
COADchr1733021241Silentrs759168920A422A0.19
DLBCchr1733291797Intronnovel0.13
ESCAchr1733088886Missense_MutationnovelF271L0.36
ESCAchr1733291945Intronnovel0.13
ESCAchr1733291672Intronnovel0.51
ESCAchr1734156043Missense_MutationnovelL164M0.11
ESCAchr17330138033'UTRnovel0.38
ESCAchr1733291983Intronnovel0.13
ESCAchr1733023860Splice_Siters199653464X399_splice0.3
ESCAchr17341566545'UTRnovel0.44
ESCAchr1733291609Intronnovel0.21
ESCAchr1733291995Intronnovel0.25
GBMchr1733014006Missense_MutationNAL500M0.75
GBMchr1733024004Silentrs544368158A351A0.41
GBMchr1733023907Missense_MutationnovelA384T0.22
GBMchr1733291547Intronnovel0.35
GBMchr1734156386Silentrs778759008F49F0.3
GBMchr1734156412Missense_MutationNAR41W0.3
HNSCchr1733291618Intronrs7514168380.3
HNSCchr1733291616Intronnovel0.19
HNSCchr1734156043Missense_MutationnovelL164M0.24
HNSCchr1734156485SilentnovelS16S0.34
HNSCchr1734156136Missense_Mutationrs779793341V133M0.11
HNSCchr1733013972Missense_MutationnovelA511D0.42
HNSCchr1734156057Missense_MutationnovelR159H0.33
HNSCchr1734156241Missense_Mutationrs758581731R98W0.27
KIRCchr1733291444Intronnovel0.49
KIRCchr1733111936Frame_Shift_DelnovelE227Afs*120.26
KIRCchr1734155998Missense_MutationnovelG179S0.07
LGGchr1734156052Missense_MutationnovelG161S0.07
LGGchr1734156403SilentNAL44L0.33
LIHCchr17341565575'UTRnovel0.11
LIHCchr1733291799Intronnovel0.31
LIHCchr17341565725'UTRnovel0.18
LIHCchr1734156101SilentNAK144K0.08
LIHCchr17330138233'UTRnovel0.33
LUADchr1733088944Missense_MutationnovelQ251H0.05
LUADchr1734156136Missense_Mutationrs779793341V133M0.36
LUADchr1733028383Missense_MutationnovelL282M0.14
LUADchr1733088934Missense_MutationnovelP255T0.33
LUADchr1734156192Missense_MutationnovelL114Q0.12
LUADchr1733291758Intronnovel0.2
LUADchr1733291448Intronnovel0.18
LUADchr1733291886Intronnovel0.39
LUADchr1733291799Intronnovel0.31
LUADchr1733016024Missense_MutationNAL462I0.23
LUADchr1733023933Missense_MutationnovelM375K0.4
LUADchr1734156233SilentnovelS100S0.16
LUADchr1733291801Intronnovel0.34
LUADchr1733291828Intronnovel0.13
LUADchr1734156187Missense_MutationNAL116V0.1
LUADchr1733025929SilentNAL347L0.28
LUADchr1733021245Missense_MutationnovelK421M0.13
LUADchr1733111975SilentnovelG216G0.23
LUADchr1733017607Nonsense_MutationnovelE456*0.14
LUADchr1733028304Missense_MutationnovelR308K0.22
LUADchr1734156337Missense_MutationNAY66H0.23
LUADchr1734156123Missense_MutationnovelL137P0.28
LUADchr1733291849Intronnovel0.21
LUADchr1733021300Missense_MutationnovelL403I0.31
LUSCchr1734156236Missense_MutationnovelF99L0.26
LUSCchr1734156476Missense_MutationnovelI19M0.19
LUSCchr1733023860Splice_SitenovelX399_splice0.21
LUSCchr1733028338Missense_MutationnovelD297Y0.3
LUSCchr1734156153Missense_MutationnovelH127P0.42
LUSCchr1734156280Missense_MutationNAV85L0.35
LUSCchr1733111944Nonsense_MutationNAE227*0.04
LUSCchr1734156464SilentNAT23T0.25
LUSCchr1733021241Silentrs759168920A422A0.19
LUSCchr1733028355Missense_MutationNAS291F0.43
LUSCchr1734156138Missense_MutationNAS132F0.22
LUSCchr1734156272SilentnovelP87P0.39
LUSCchr1734156347Missense_MutationnovelE62D0.27
LUSCchr1733028338Missense_Mutationrs757867324D297H0.1
LUSCchr1733112060Missense_MutationNAT188K0.19
LUSCchr1733291909Intronrs7509393310.57
LUSCchr1733111986Frame_Shift_InsNAT213Dfs*150.51
LUSCchr1734156065SilentNAF156F0.62
OVchr1733021284Frame_Shift_DelNAL405Ffs*20.69
OVchr1734156385Missense_Mutationrs753583147V50M0.28
PAADchr1734156305SilentnovelV76V0.08
PAADchr1734156161Silentrs770764384P124P0.11
PRADchr1733291438Intronnovel0.15
PRADchr1733028260Missense_MutationnovelR323C0.22
PRADchr1733291652Intronnovel0.15
PRADchr1733028313Missense_MutationNAT305I0.06
PRADchr1733291574Intronnovel0.19
PRADchr1734156099Missense_MutationNAH145P0.11
READchr1733111986Frame_Shift_InsNAT213Dfs*150.08
READchr1734156046Missense_MutationNAD163Y0.16
READchr1733291762IntronNA0.19
READchr1733017603Splice_SiteNAX456_splice0.11
READchr17341565345'UTRnovel0.19
SARCchr1734156143SilentnovelD130D0.33
SARCchr1734156137Silentrs374323534S132S0.25
SARCchr1733025973Frame_Shift_DelnovelP332Lfs*160.23
SARCchr1733021265In_Frame_DelnovelY414del0.23
SKCMchr17341565925'UTRnovel0.55
SKCMchr1733111966SilentNAI219I0.29
SKCMchr1734156246Missense_MutationNAG96D0.58
SKCMchr17341565465'UTRnovel0.54
SKCMchr1733111927Nonsense_MutationNAW232*0.26
SKCMchr1733088893SilentNAF268F0.53
SKCMchr1733025981Splice_RegionnovelG329G0.22
SKCMchr1734156160Missense_MutationNAD125N0.4
SKCMchr1734156434SilentNAF33F0.45
SKCMchr1733291491IntronNA0.43
SKCMchr1733016019SilentNAL463L0.25
SKCMchr1733028354SilentNAS291S0.37
SKCMchr1734156301Missense_Mutationrs749146881E78K0.34
SKCMchr1733111992Missense_MutationnovelG211R0.38
SKCMchr1733088929Silentrs138635070F256F0.11
SKCMchr1733028329Missense_MutationNAP300S0.14
SKCMchr1734156351Missense_MutationnovelS61F0.28
SKCMchr1733023982Missense_MutationNAL359F0.43
SKCMchr1733023998SilentNAK353K0.07
SKCMchr1734156071SilentNAL154L0.18
SKCMchr1733023929SilentNAV376V0.63
SKCMchr17341565735'UTRrs7567243050.39
SKCMchr1734156141Missense_MutationNAP131L0.45
SKCMchr1734156481Missense_MutationnovelQ18K0.15
SKCMchr1733015997Missense_Mutationrs780407455D471N0.14
SKCMchr1733023929SilentNAV376V0.51
SKCMchr1733023941SilentNAE372E0.44
SKCMchr1733025975SilentNAA331A0.28
SKCMchr1733112067Missense_MutationNAV186L0.17
SKCMchr1734156058Missense_MutationNAR159C0.07
SKCMchr1734156137Silentrs374323534S132S0.41
SKCMchr1734156234Missense_MutationNAS100F0.67
SKCMchr1734155984SilentnovelF183F0.55
SKCMchr1733111947Missense_MutationNAD226N0.15
SKCMchr1733088863Splice_RegionnovelR278R0.29
SKCMchr1734156043SilentnovelL164L0.8
STADchr1733291450Intronnovel0.34
STADchr1733015986SilentNAS474S0.22
STADchr1733021242Missense_MutationNAA422V0.21
STADchr1733291512Intronnovel0.15
STADchr1733023858Splice_Regionnovel0.13
STADchr1733021241Silentrs759168920A422A0.47
STADchr1734156464SilentNAT23T0.19
STADchr1733291470Intronnovel0.14
STADchr1733025952Missense_MutationnovelH339R0.24
STADchr1734156058Missense_MutationNAR159C0.3
STADchr1733291750Intronnovel0.19
STADchr1733291488Intronnovel0.08
STADchr1733088983Silentrs556982917T238T0.28
STADchr1733111919Missense_MutationNAT235I0.16
STADchr1733291760Intronnovel0.45
STADchr1733291818Intronnovel0.47
THYMchr1733291926Intronnovel0.31
UCECchr1733023938SilentnovelL373L0.06
UCECchr1733291458Intronnovel0.35
UCECchr1733028312SilentNAT305T0.45
UCECchr1734156500SilentnovelS11S0.35
UCECchr1733013999Missense_Mutationrs201100877T502M0.46
UCECchr1734156386Silentrs778759008F49F0.49
UCECchr17330136243'UTRnovel0.43
UCECchr1733017611SilentNAI454I0.27
UCECchr1734156445Missense_MutationNAR30C0.36
UCECchr1733111918Splice_RegionNAT235T0.38
UCECchr17330137923'UTRrs1432294080.15
UCECchr1734156411Missense_MutationNAR41Q0.22
UCECchr17330134993'UTRnovel0.1
UCECchr1733015970Splice_SitenovelX479_splice0.25
UCECchr17330138763'UTRnovel0.36
UCECchr1734156476SilentnovelI19I0.58
UCECchr1733021255Missense_MutationnovelE418Q0.25
UCECchr1733021227Missense_MutationnovelA427V0.62
UCECchr1733015970Splice_SitenovelX479_splice0.3
UCECchr17330137703'UTRnovel0.39
UCECchr1733017640Missense_MutationnovelL445I0.48
UCECchr1734156389SilentnovelA48A0.26
UCECchr1733023908SilentnovelS383S0.3
UCECchr1733028267SilentnovelC320C0.07
UCECchr1733023858Splice_Regionnovel0.35
UCECchr1733028338Nonsense_MutationnovelL296_D297insPLSIC*ITTT0.07
UCECchr17330138523'UTRnovel0.44
UCECchr1733112026Silentrs201936906G199G0.56
UCECchr1733028330Frame_Shift_DelnovelP300Lfs*480.11
UCECchr1734156386Silentrs778759008F49F0.49
UCECchr1734156279Missense_MutationnovelV85A0.38
UCECchr1734156479SilentnovelQ18Q0.3
UCECchr1733021284Frame_Shift_InsnovelF408Yfs*30.08
UCECchr17330137663'UTRnovel0.3
UCECchr17341566545'UTRnovel0.44
UCECchr1734156002SilentnovelE177E0.15
UCECchr17330135573'UTRnovel0.51
UCECchr17330136493'UTRnovel0.53
UCECchr1734156422Frame_Shift_InsnovelL38Afs*30.09
UCECchr1733028339Silentrs200229106L296L0.28
UCECchr1733111978Silentrs748958495N215N0.46
UCECchr1734156381Missense_MutationnovelG51D0.27
UCECchr1733015995Silentrs147559460D471D0.11
UCECchr1733291632Intronnovel0.58
UCECchr1733028265Missense_MutationnovelN321T0.35
UCECchr1734156137Silentrs374323534S132S0.09
UCECchr1733291683Intronnovel0.38
UCECchr1734156121Missense_Mutationrs565904010R138W0.48
UCSchr1734156121Missense_Mutationrs565904010R138W0.42
UVMchr1734156161Silentrs770764384P124P0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.11530.0058042
DLBCDEL00.18166
LGGAMP0.02340.19963
PAADAMP0.09240.20695
PAADDEL0.06520.13216
SKCMAMP0.13629.6912e-06
THCADEL0.0020.221
UCSDEL0.3750.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
KIRC0.038

Kaplan-Meier Survival Analysis

STAD0.032

Kaplan-Meier Survival Analysis

SKCM0.0005

Kaplan-Meier Survival Analysis

CESC0.047

Kaplan-Meier Survival Analysis

LAML0.021

Kaplan-Meier Survival Analysis

GBM0.018

Kaplan-Meier Survival Analysis

DLBC0.047

Kaplan-Meier Survival Analysis

LGG0.018

Kaplan-Meier Survival Analysis

CHOL0.011

Kaplan-Meier Survival Analysis

OV0.028

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000108684 (Gene tree)
Gene ID
40
Gene Symbol
ASIC2
Alias
ASIC2a|BNC1|BNaC1|hBNaC1|MDEG|ACCN|ACCN1
Full Name
acid sensing ion channel subunit 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
1,161,878 bases
Position
chr17:33,013,087-34,174,964
Accession
99
RBP type
non-canonical RBP
Summary
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000448983ASIC2-203750--- (aa)--
ENST00000225823ASIC2-2013443-ENSP00000225823563 (aa)-Q16515
ENST00000583395ASIC2-205508--- (aa)--
ENST00000579816ASIC2-204559--- (aa)--
ENST00000359872ASIC2-2023179-ENSP00000352934512 (aa)-Q16515
Gene Model
Click here to download ENSG00000108684's gene model file
Pathways
Pathway IDPathway NameSource
hsa04742Taste transductionKEGG
hsa04750Inflammatory mediator regulation of TRP channelsKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000108684Body Weight2.38648693595419E-817903300
ENSG00000108684Body Weight2.42777359297714E-817903300
ENSG00000108684Body Weight2.10203284994182E-817903300
ENSG00000108684Body Weight2.11323545786742E-817903300
ENSG00000108684Gout3.69207964046275E-11-
ENSG00000108684Stroke3.0862344E-00419369658
ENSG00000108684Stroke5.6735390E-00419369658
ENSG00000108684Blood Pressure8.823e-005-
ENSG00000108684Fantasy8.925e-005-
ENSG00000108684Fantasy4.508e-005-
ENSG00000108684Emotions7.442e-005-
ENSG00000108684Body Mass Index6.1580000E-005-
ENSG00000108684Obesity3.6830000E-005-
ENSG00000108684Obesity1.2520000E-005-
ENSG00000108684Body Weight9.1940000E-005-
ENSG00000108684Body Weight1.4780000E-005-
ENSG00000108684Blood Pressure5.1620000E-005-
ENSG00000108684C-Reactive Protein5.0810000E-005-
ENSG00000108684Cholesterol, HDL8.5830000E-005-
ENSG00000108684Cholesterol, HDL6.5130000E-005-
ENSG00000108684Leukocyte Count9.9640000E-005-
ENSG00000108684Body Mass Index4.8274079E-006-
ENSG00000108684Anatomy5.6168726E-005-
ENSG00000108684Platelet Function Tests2.0100000E-006-
ENSG00000108684Platelet Function Tests1.0150300E-005-
ENSG00000108684Platelet Function Tests2.1159977E-007-
ENSG00000108684Platelet Function Tests8.2978604E-006-
ENSG00000108684Platelet Function Tests2.6419798E-006-
ENSG00000108684Platelet Function Tests1.0161654E-006-
ENSG00000108684Platelet Function Tests1.3086609E-006-
ENSG00000108684Platelet Function Tests1.3767600E-005-
ENSG00000108684Child Development Disorders, Pervasive6.3000000E-005-
ENSG00000108684Cytokine Receptor gp1304.4610000E-005-
ENSG00000108684Homocysteine1.3650000E-005-
ENSG00000108684Homocysteine2.3800000E-005-
ENSG00000108684Sex Hormone-Binding Globulin1.1490000E-006-
ENSG000001086843-hydroxy-1-methylpropylmercapturic acid1E-626053186
ENSG00000108684Smoking1E-626053186
ENSG00000108684Angiotensin-Converting Enzyme Inhibitors7E-728030426
ENSG00000108684Bronchodilator Agents5E-626634245
ENSG00000108684Lung Volume Measurements5E-626634245
ENSG00000108684Blood Coagulation Factors2E-621810271
ENSG00000108684Factor VIII2E-621810271
ENSG00000108684Electrocardiography1E-724324551
ENSG00000108684Trypanosoma cruzi1E-724324551
ENSG00000108684Amyotrophic lateral sclerosis 14E-624529757
ENSG00000108684Longevity6E-626912274
ENSG00000108684Electrocardiography9E-624324551
ENSG00000108684Trypanosoma cruzi9E-624324551
ENSG00000108684Coronary Disease6E-621378988
ENSG00000108684Hypothyroidism7E-622493691
ENSG00000108684Chemokine CCL24E-623251661
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000108684rs177828051733568429?Angiotensin-converting enzyme inhibitor intolerance28030426[1.444594-2.33528]1.836717EFO_0005325
ENSG00000108684rs1449089581733205396APost bronchodilator FEV1/FVC ratio26634245unit increase0.616GO_0097366|EFO_0004713
ENSG00000108684rs72138121733121631CLongevity26912274[NR]1.29EFO_0004300
ENSG00000108684rs3206371733338310?Amyotrophic lateral sclerosis (sporadic)24529757EFO_0001357
ENSG00000108684rs728191261733158862?3-hydroxy-1-methylpropylmercapturic acid levels in smokers26053186[NR] unit decrease0.5993EFO_0004318|EFO_0007015
ENSG00000108684rs1173642311733979404?PR interval in Tripanosoma cruzi seropositivity24324551EFO_0004462|EFO_0005530
ENSG00000108684rs1169088161734095680?QT interval in Tripanosoma cruzi seropositivity24324551EFO_0004682|EFO_0005530
ENSG00000108684rs178084611733066684AObesity-related traits23251661[NR] pg/mL increase0.02EFO_0004749
ENSG00000108684rs99102921733037523TMosquito bite size28199695[0.02-0.05] unit decrease0.0347797EFO_0008378
ENSG00000108684rs116518431733454361?Serum folate levels29953918EFO_0005111
ENSG00000108684rs99153561733285476ASelf-reported math ability30038396[0.0093-0.0171] unit increase0.0132EFO_0004875
ENSG00000108684rs72137211733292327GHighest math class taken30038396[0.008-0.017] unit increase0.0125EFO_0004875
ENSG00000108684rs8705891733287436AEducational attainment (MTAG)30038396[0.0062-0.0112] unit decrease0.0087EFO_0004784
ENSG00000108684rs99153561733285476ASelf-reported math ability (MTAG)30038396[0.01-0.017] unit increase0.0135EFO_0004875
ENSG00000108684rs8705891733287436AHighest math class taken (MTAG)30038396[0.0098-0.0164] unit decrease0.0131EFO_0004875
ENSG00000108684rs596920401733313040TCognitive performance (MTAG)30038396[0.0096-0.019] unit increase0.0143EFO_0008354
ENSG00000108684rs3197481733227515AMenstruation quality of life impact (bowel movement)29855537[0.11-0.26] unit decrease0.1860469EFO_0009366
ENSG00000108684rs1172177981733156215CInterleukin-16 levels27989323[0.12-0.29] SD units increase0.2036EFO_0008173
ENSG00000108684rs13544921733410403AvWF and FVIII levels21810271[0.10-0.22] IU/dL increase0.16EFO_0004630|EFO_0004634
ENSG00000108684rs99017561734137135AHypothyroidism22493691[1.11-1.32]1.21EFO_0004705
ENSG00000108684rs116500661733960430?Coronary heart disease21378988EFO_0001645
ENSG00000108684rs116528741733643464GSevere gingival inflammation28459102[0.48-1] unit increase0.740595HP_0000225
ENSG00000108684rs803434291733229663AClopidogrel active metabolite levels28207573[NR] unit increase8.01EFO_0007966
ENSG00000108684rs341875631733399144TDepression (broad)29662059[0.004-0.0088] unit decrease0.0064EFO_0003761
ENSG00000108684rs5607695641733036696?General cognitive ability29844566z-score decrease4.777EFO_0004337
ENSG00000108684rs1400166811733973273?Reaction time29844566[0.0044-0.0111] unit increase0.0077347EFO_0008393
ENSG00000108684rs18758721733468698APlasma parathyroid hormone levels30134803[0.081-0.199] unit increase0.14EFO_0004752
ENSG00000108684rs45100731733128407?Response to long-term oxygen therapy in chronic obstructive pulmonary disease30353303EFO_0009796|EFO_0000341
ENSG00000108684rs20891641733384425?Adolescent idiopathic scoliosis30019117EFO_0005423
ENSG00000108684rs8705891733287436AEducational attainment (years of education)30038396[0.0052-0.0106] unit decrease0.0079EFO_0004784
ENSG00000108684rs99036581733729207GSerum bilirubin levels in metabolic syndrome30621171[0.13-0.3] mg/dL increase0.218EFO_0004570|EFO_0000195
ENSG00000108684rs739824351733146437?Body mass index30595370EFO_0004340
ENSG00000108684rs355780351733422168?Body mass index30595370EFO_0004340
ENSG00000108684rs124504651733053293GPolycystic ovary syndrome30343302NR unit decrease0.8755EFO_0000660
ENSG00000108684rs43653291733298869TChronotype306968231.0195894EFO_0008328
ENSG00000108684rs129382351733298182TChronotype30696823[0.0061-0.0128] unit increase0.00944011EFO_0008328
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108684's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003026regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback-IEAProcess
GO:0005515protein binding11802773.IPIFunction
GO:0005886plasma membrane-TASComponent
GO:0005887integral component of plasma membrane-IEAComponent
GO:0007268chemical synaptic transmission8626462.TASProcess
GO:0007417central nervous system development8626462.TASProcess
GO:0007422peripheral nervous system development8626462.TASProcess
GO:0007602phototransduction-IEAProcess
GO:0007605sensory perception of sound-IEAProcess
GO:0010447response to acidic pH-IEAProcess
GO:0015280ligand-gated sodium channel activity-IEAFunction
GO:0015672monovalent inorganic cation transport8626462.TASProcess
GO:0019229regulation of vasoconstriction-IEAProcess
GO:0034220ion transmembrane transport-TASProcess
GO:0034765regulation of ion transmembrane transport-IEAProcess
GO:0035418protein localization to synapse-IEAProcess
GO:0035725sodium ion transmembrane transport-IEAProcess
GO:0042391regulation of membrane potential-IEAProcess
GO:0043025neuronal cell body-IEAComponent
GO:0043066negative regulation of apoptotic process-IEAProcess
GO:0043197dendritic spine-IEAComponent
GO:0050915sensory perception of sour taste19812697.IMPProcess
GO:0050974detection of mechanical stimulus involved in sensory perception-IEAProcess
GO:0051965positive regulation of synapse assembly-IEAProcess
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