EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25103363Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis.Mol Cancer2014 Aug 7Yao Wdoi: 10.1186/1476-4598-13-187.
27862305A loss of profilin-1 in late-stage oral squamous cell carcinoma.J Oral Pathol Med2017 AugAdami GRdoi: 10.1111/jop.12523
23326535Profilin 1 as a target for cathepsin X activity in tumor cells.PLoS One2013Pear Fonovi Udoi: 10.1371/journal.pone.0053918
26842845Profilin potentiates chemotherapeutic agents mediated cell death via suppression of NF-??B and upregulation of p53.Apoptosis2016 AprZaidi AHdoi: 10.1007/s10495-016-1222-9.
24747440Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression throughHIF-1α accumulation.Nat Cell Biol2014 MayFan Ydoi: 10.1038/ncb2954
14767055Tumor suppressor activity of profilin requires a functional actin binding site.Mol Biol Cell2004 AprWittenmayer N-
24661873C-Terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration.Biochem Biophys Res Commun2014 Apr 18Choi YNdoi: 10.1016/j.bbrc.2014.03.061
18384219Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.Arch Pathol Lab Med2008 AprChan CMdoi: 10.1043/1543-2165(2008)132[675:PCONCC]2.0.CO;2.
23686314Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis.Oncogene2014 Apr 17Ding Zdoi: 10.1038/onc.2013.166
23430586Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1.Tumour Biol2013 JunLiu Hdoi: 10.1007/s13277-013-0708-0
19115233Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.J Cell Physiol2009 MayBae YHdoi: 10.1002/jcp.21677.
23827010Profilin-1 versus profilin-2: two faces of the same coin?Breast Cancer Res2013 Jun 27Ding Zdoi: 10.1186/bcr3433.
25454514Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.OMICS2014 DecCoumans JVdoi: 10.1089/omi.2014.0075.
23331014Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.Curr Mol Med2013 MarYao W-
28170369LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction.Med Sci Monit2017 Feb 7Liu Y-
28688208Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.Eur J Immunol2017 SepSchoppmeyer Rdoi: 10.1002/eji.201747124
27683119Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models.Oncotarget2016 Oct 25Frantzi Mdoi: 10.18632/oncotarget.12218.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr174946882Intronnovel0.53
BLCAchr174946883Intronnovel0.5
BLCAchr174946667Missense_MutationNAA96T0.2
BLCAchr174948383Missense_MutationnovelW4C0.31
BLCAchr174946680Missense_MutationnovelK91N0.44
BRCAchr174946847Intronnovel0.27
CESCchr174945974Missense_MutationnovelE117K0.39
CESCchr174945917Missense_MutationnovelR136W0.24
CESCchr174948370Missense_MutationnovelD9H0.05
COADchr174945922Missense_MutationnovelH134L0.39
DLBCchr174948262Splice_SitenovelX44_splice0.43
ESCAchr174945912SilentnovelR137R0.18
GBMchr1749458533'UTRnovel0.12
GBMchr174948384Missense_MutationnovelW4L0.07
GBMchr174946738Nonsense_MutationnovelS72*0.06
HNSCchr1749458693'UTRnovel0.38
HNSCchr174946661Frame_Shift_InsnovelT98Hfs*100.2
KIRCchr1749458453'UTRnovel0.16
KIRPchr174946705Missense_MutationnovelE83V0.36
LUADchr1749458823'UTRnovel0.14
LUSCchr1749458743'UTRrs18042200.29
OVchr1749458923'UTRnovel0.15
OVchr174947128Intronnovel0.8
OVchr174945921Missense_MutationnovelH134Q0.2
PRADchr174946744In_Frame_DelnovelK70del0.28
SKCMchr174946887Intronnovel0.29
SKCMchr174946911Intronnovel0.5
STADchr174946856Intronnovel0.2
STADchr174945927SilentnovelA132A0.4
STADchr174948313In_Frame_DelnovelC17_D27del0.39
UCECchr1749456783'UTRnovel0.33
UCECchr174946936Intronnovel0.6
UCECchr1749456783'UTRnovel0.63
UCECchr174945968Missense_MutationnovelV119I0.04
UCECchr174946833Intronnovel0.1
UCECchr1749458953'UTRrs7786159990.48
UCECchr1749456653'UTRnovel0.37
UCECchr1749484325'UTRnovel0.14
UCECchr174946938Intronnovel0.29
UCECchr1749456783'UTRnovel0.53
UCECchr174946640Missense_MutationNAK105E0.35
UCECchr1749456783'UTRnovel0.27
UCECchr1749456783'UTRnovel0.41
UCECchr174945943Missense_MutationnovelK127R0.25
UCECchr174946824Splice_Regionnovel0.2
UCECchr174946756Missense_MutationnovelL66R0.28
UCECchr1749456613'UTRnovel0.11
UCECchr174946781Missense_MutationnovelS58R0.29
UCECchr1749456783'UTRnovel0.59
UCECchr174946898Intronnovel0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.20830.18166
LAMLDEL0.07330.12511
LIHCDEL0.54863.9592e-10
THCADEL0.0160.221

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.011

Kaplan-Meier Survival Analysis

ACC0.00082

Kaplan-Meier Survival Analysis

HNSC0.048

Kaplan-Meier Survival Analysis

PRAD0.044

Kaplan-Meier Survival Analysis

LAML0.0031

Kaplan-Meier Survival Analysis

UCEC0.021

Kaplan-Meier Survival Analysis

LIHC0.0028

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.014

Kaplan-Meier Survival Analysis

LUAD0.013

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.00088

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000108518 (Gene tree)
Gene ID
5216
Gene Symbol
PFN1
Alias
N
Full Name
profilin 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
3,437 bases
Position
chr17:4,945,650-4,949,086
Accession
8881
RBP type
non-canonical RBP
Summary
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28980860 behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Autophagy2017Uversky VNdoi: 10.1080/15548627.2017.1384889
27838743Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.Cell Mol Life Sci2017 AprSantamaria Ndoi: 10.1007/s00018-016-2416-6
23041957How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?Curr Opin Neurol2012 DecBaloh RHdoi: 10.1097/WCO.0b013e32835a269b.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000225655PFN1-2011291XM_017024761ENSP00000225655140 (aa)XP_016880250P07737
ENST00000574872PFN1-2031173-ENSP00000465019104 (aa)-K7EJ44
ENST00000572383PFN1-202539-ENSP00000460363165 (aa)-I3L3D5
Gene Model
Click here to download ENSG00000108518's gene model file
Pathways
Pathway IDPathway NameSource
hsa04015Rap1 signaling pathwayKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05131ShigellosisKEGG
hsa05132Salmonella infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108518's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000108518PFN19963.043ENSG00000070087PFN29963.333Homo_sapiens
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000774adenyl-nucleotide exchange factor activity7758455.IDAFunction
GO:0001843neural tube closure-IEAProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0003779actin binding21873635.IBAFunction
GO:0003779actin binding7758455.17914456.IPIFunction
GO:0003785actin monomer binding18573880.IDAFunction
GO:0005515protein binding9822597.9843499.16531231.17470807.18573880.18689676.19000816.19338310.23153535.24700464.IPIFunction
GO:0005546phosphatidylinositol-4,5-bisphosphate binding7758455.IDAFunction
GO:0005634nucleus24700464.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm24700464.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005938cell cortex24700464.IDAComponent
GO:0006357regulation of transcription by RNA polymerase II-IEAProcess
GO:0010634positive regulation of epithelial cell migration23153535.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0017048Rho GTPase binding-IEAFunction
GO:0030036actin cytoskeleton organization-IEAProcess
GO:0030833regulation of actin filament polymerization21873635.IBAProcess
GO:0030837negative regulation of actin filament polymerization7758455.IDAProcess
GO:0030838positive regulation of actin filament polymerization23153535.IGIProcess
GO:0032232negative regulation of actin filament bundle assembly23153535.IMPProcess
GO:0032233positive regulation of actin filament bundle assembly21873635.IBAProcess
GO:0032781positive regulation of ATPase activity7758455.IDAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0050821protein stabilization18573880.IDAProcess
GO:0051497negative regulation of stress fiber assembly23153535.IMPProcess
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TASProcess
GO:0060074synapse maturation-IEAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0070064proline-rich region binding17914456.IPIFunction
GO:0072562blood microparticle22516433.HDAComponent
GO:0098885modification of postsynaptic actin cytoskeleton-IEAProcess
GO:0098978glutamatergic synapse-IEAComponent
GO:1900029positive regulation of ruffle assembly23153535.IMPProcess
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