EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25103363	Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis.	Mol Cancer	2014 Aug 7	Yao W	doi: 10.1186/1476-4598-13-187.
27862305	A loss of profilin-1 in late-stage oral squamous cell carcinoma.	J Oral Pathol Med	2017 Aug	Adami GR	doi: 10.1111/jop.12523
23326535	Profilin 1 as a target for cathepsin X activity in tumor cells.	PLoS One	2013	Pear Fonovi U	doi: 10.1371/journal.pone.0053918
26842845	Profilin potentiates chemotherapeutic agents mediated cell death via suppression of NF-??B and upregulation of p53.	Apoptosis	2016 Apr	Zaidi AH	doi: 10.1007/s10495-016-1222-9.
24747440	Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression throughHIF-1α accumulation.	Nat Cell Biol	2014 May	Fan Y	doi: 10.1038/ncb2954
14767055	Tumor suppressor activity of profilin requires a functional actin binding site.	Mol Biol Cell	2004 Apr	Wittenmayer N	-
24661873	C-Terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration.	Biochem Biophys Res Commun	2014 Apr 18	Choi YN	doi: 10.1016/j.bbrc.2014.03.061
18384219	Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.	Arch Pathol Lab Med	2008 Apr	Chan CM	doi: 10.1043/1543-2165(2008)132[675:PCONCC]2.0.CO;2.
23686314	Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis.	Oncogene	2014 Apr 17	Ding Z	doi: 10.1038/onc.2013.166
23430586	Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1.	Tumour Biol	2013 Jun	Liu H	doi: 10.1007/s13277-013-0708-0
19115233	Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.	J Cell Physiol	2009 May	Bae YH	doi: 10.1002/jcp.21677.
23827010	Profilin-1 versus profilin-2: two faces of the same coin?	Breast Cancer Res	2013 Jun 27	Ding Z	doi: 10.1186/bcr3433.
25454514	Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.	OMICS	2014 Dec	Coumans JV	doi: 10.1089/omi.2014.0075.
23331014	Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.	Curr Mol Med	2013 Mar	Yao W	-
28170369	LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction.	Med Sci Monit	2017 Feb 7	Liu Y	-
28688208	Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.	Eur J Immunol	2017 Sep	Schoppmeyer R	doi: 10.1002/eji.201747124
27683119	Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models.	Oncotarget	2016 Oct 25	Frantzi M	doi: 10.18632/oncotarget.12218.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	4946882	Intron	novel		0.53
BLCA	chr17	4946883	Intron	novel		0.5
BLCA	chr17	4946667	Missense_Mutation	NA	A96T	0.2
BLCA	chr17	4948383	Missense_Mutation	novel	W4C	0.31
BLCA	chr17	4946680	Missense_Mutation	novel	K91N	0.44
BRCA	chr17	4946847	Intron	novel		0.27
CESC	chr17	4945974	Missense_Mutation	novel	E117K	0.39
CESC	chr17	4945917	Missense_Mutation	novel	R136W	0.24
CESC	chr17	4948370	Missense_Mutation	novel	D9H	0.05
COAD	chr17	4945922	Missense_Mutation	novel	H134L	0.39
DLBC	chr17	4948262	Splice_Site	novel	X44_splice	0.43
ESCA	chr17	4945912	Silent	novel	R137R	0.18
GBM	chr17	4945853	3'UTR	novel		0.12
GBM	chr17	4948384	Missense_Mutation	novel	W4L	0.07
GBM	chr17	4946738	Nonsense_Mutation	novel	S72*	0.06
HNSC	chr17	4945869	3'UTR	novel		0.38
HNSC	chr17	4946661	Frame_Shift_Ins	novel	*T98Hfs10**	0.2
KIRC	chr17	4945845	3'UTR	novel		0.16
KIRP	chr17	4946705	Missense_Mutation	novel	E83V	0.36
LUAD	chr17	4945882	3'UTR	novel		0.14
LUSC	chr17	4945874	3'UTR	rs1804220		0.29
OV	chr17	4945892	3'UTR	novel		0.15
OV	chr17	4947128	Intron	novel		0.8
OV	chr17	4945921	Missense_Mutation	novel	H134Q	0.2
PRAD	chr17	4946744	In_Frame_Del	novel	K70del	0.28
SKCM	chr17	4946887	Intron	novel		0.29
SKCM	chr17	4946911	Intron	novel		0.5
STAD	chr17	4946856	Intron	novel		0.2
STAD	chr17	4945927	Silent	novel	A132A	0.4
STAD	chr17	4948313	In_Frame_Del	novel	C17_D27del	0.39
UCEC	chr17	4945678	3'UTR	novel		0.33
UCEC	chr17	4946936	Intron	novel		0.6
UCEC	chr17	4945678	3'UTR	novel		0.63
UCEC	chr17	4945968	Missense_Mutation	novel	V119I	0.04
UCEC	chr17	4946833	Intron	novel		0.1
UCEC	chr17	4945895	3'UTR	rs778615999		0.48
UCEC	chr17	4945665	3'UTR	novel		0.37
UCEC	chr17	4948432	5'UTR	novel		0.14
UCEC	chr17	4946938	Intron	novel		0.29
UCEC	chr17	4945678	3'UTR	novel		0.53
UCEC	chr17	4946640	Missense_Mutation	NA	K105E	0.35
UCEC	chr17	4945678	3'UTR	novel		0.27
UCEC	chr17	4945678	3'UTR	novel		0.41
UCEC	chr17	4945943	Missense_Mutation	novel	K127R	0.25
UCEC	chr17	4946824	Splice_Region	novel		0.2
UCEC	chr17	4946756	Missense_Mutation	novel	L66R	0.28
UCEC	chr17	4945661	3'UTR	novel		0.11
UCEC	chr17	4946781	Missense_Mutation	novel	S58R	0.29
UCEC	chr17	4945678	3'UTR	novel		0.59
UCEC	chr17	4946898	Intron	novel		0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5486	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.011	Kaplan-Meier Survival Analysis
ACC	0.00082	Kaplan-Meier Survival Analysis
HNSC	0.048	Kaplan-Meier Survival Analysis
PRAD	0.044	Kaplan-Meier Survival Analysis
LAML	0.0031	Kaplan-Meier Survival Analysis
UCEC	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0028	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.014	Kaplan-Meier Survival Analysis
LUAD	0.013	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis
OV	0.00088	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108518 (Gene tree)
Gene ID: 5216
Gene Symbol: PFN1
Alias: N
Full Name: profilin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,437 bases
Position: chr17:4,945,650-4,949,086
Accession: 8881
RBP type: non-canonical RBP
Summary: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28980860	behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.	Autophagy	2017	Uversky VN	doi: 10.1080/15548627.2017.1384889
27838743	Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.	Cell Mol Life Sci	2017 Apr	Santamaria N	doi: 10.1007/s00018-016-2416-6
23041957	How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?	Curr Opin Neurol	2012 Dec	Baloh RH	doi: 10.1097/WCO.0b013e32835a269b.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000225655	PFN1-201	1291	XM_017024761	ENSP00000225655	140 (aa)	XP_016880250	P07737
ENST00000574872	PFN1-203	1173	-	ENSP00000465019	104 (aa)	-	K7EJ44
ENST00000572383	PFN1-202	539	-	ENSP00000460363	165 (aa)	-	I3L3D5

Gene Model

Click here to download ENSG00000108518's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108518's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108518	PFN1	99	63.043	ENSG00000070087	PFN2	99	63.333	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000774	adenyl-nucleotide exchange factor activity	7758455.	IDA	Function
GO:0001843	neural tube closure	-	IEA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003779	actin binding	21873635.	IBA	Function
GO:0003779	actin binding	7758455.17914456.	IPI	Function
GO:0003785	actin monomer binding	18573880.	IDA	Function
GO:0005515	protein binding	9822597.9843499.16531231.17470807.18573880.18689676.19000816.19338310.23153535.24700464.	IPI	Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	7758455.	IDA	Function
GO:0005634	nucleus	24700464.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	24700464.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005938	cell cortex	24700464.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0010634	positive regulation of epithelial cell migration	23153535.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0017048	Rho GTPase binding	-	IEA	Function
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0030833	regulation of actin filament polymerization	21873635.	IBA	Process
GO:0030837	negative regulation of actin filament polymerization	7758455.	IDA	Process
GO:0030838	positive regulation of actin filament polymerization	23153535.	IGI	Process
GO:0032232	negative regulation of actin filament bundle assembly	23153535.	IMP	Process
GO:0032233	positive regulation of actin filament bundle assembly	21873635.	IBA	Process
GO:0032781	positive regulation of ATPase activity	7758455.	IDA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0050821	protein stabilization	18573880.	IDA	Process
GO:0051497	negative regulation of stress fiber assembly	23153535.	IMP	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0060074	synapse maturation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0070064	proline-rich region binding	17914456.	IPI	Function
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:0098885	modification of postsynaptic actin cytoskeleton	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1900029	positive regulation of ruffle assembly	23153535.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.