EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23444224	Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.	Clin Cancer Res	2013 Apr 15	Martens-de Kemp SR	doi: 10.1158/1078-0432.CCR-12-2539
22020938	Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.	J Biol Chem	2011 Dec 16	Kojima Y	doi: 10.1074/jbc.M111.309377
26242264	Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis.	Tumour Biol	2016 Jan	Zhu J	doi: 10.1007/s13277-015-3839-7
22125623	Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.	PLoS One	2011	van der Watt PJ	doi: 10.1371/journal.pone.0027723
23557333	The nuclear import receptor Kpnβ1 and its potential as an anticancer therapeutic target.	Crit Rev Eukaryot Gene Expr	2013	van der Watt PJ	-
19117056	The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.	Int J Cancer	2009 Apr 15	van der Watt PJ	doi: 10.1002/ijc.24146.
25960398	Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1.	Biochim Biophys Acta	2015 Aug	Kuusisto HV	doi: 10.1016/j.bbamcr.2015.05.002
24398670	Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells.	Carcinogenesis	2014 May	Angus L	doi: 10.1093/carcin/bgt491
28427184	KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells.	Oncotarget	2017 May 16	Stelma T	doi: 10.18632/oncotarget.15834.
29251332	Suppression of Kpnβ1 expression inhibits human breast cancer cell proliferation by abrogating nuclear transport of Her2.	Oncol Rep	2018 Feb	Sheng C	doi: 10.3892/or.2017.6151
29622086	High Kpnβ1 expression promotes non-small cell lung cancer proliferation and chemoresistance via the PI3-kinase/AKT pathway.	Tissue Cell	2018 Apr	Wang H	doi: 10.1016/j.tice.2018.02.003

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	47682476	3'UTR	novel		0.12
BLCA	chr17	47657023	Missense_Mutation	novel	S149L	0.32
BLCA	chr17	47669679	Missense_Mutation	novel	A409G	0.33
BLCA	chr17	47677100	Silent	novel	V692V	0.2
BLCA	chr17	47673559	Missense_Mutation	NA	Q589K	0.52
BLCA	chr17	47673056	Missense_Mutation	NA	Y529C	0.36
BLCA	chr17	47652789	Missense_Mutation	novel	L65F	0.18	IBN_N
BLCA	chr17	47658550	Missense_Mutation	novel	A176T	0.39
BLCA	chr17	47680650	Nonsense_Mutation	novel	K871delinsSS*	0.07
BLCA	chr17	47669708	Missense_Mutation	NA	D419H	0.12
BLCA	chr17	47670809	Silent	novel	Q508Q	0.15
BLCA	chr17	47650400	Missense_Mutation	novel	E19Q	0.31
BLCA	chr17	47680650	Nonsense_Mutation	novel	K871delinsSS*	0.11
BLCA	chr17	47674679	Missense_Mutation	NA	I603M	0.06
BLCA	chr17	47650388	Missense_Mutation	NA	R15G	0.24
BLCA	chr17	47682430	3'UTR	novel		0.18
BRCA	chr17	47670720	Missense_Mutation	novel	E479K	0.06
BRCA	chr17	47669723	Missense_Mutation	novel	V424F	0.1
BRCA	chr17	47656971	Missense_Mutation	NA	Q132K	0.58
BRCA	chr17	47656881	Missense_Mutation	NA	E102K	0.2
BRCA	chr17	47673126	Missense_Mutation	NA	L552F	0.2
BRCA	chr17	47656907	Nonsense_Mutation	novel	*Q111Efs4**	0.09
BRCA	chr17	47677020	Missense_Mutation	NA	V666L	0.32
BRCA	chr17	47673126	Missense_Mutation	NA	L552F	0.06
BRCA	chr17	47676431	Nonsense_Mutation	novel	*K645_Y646insECQGF**	0.05
BRCA	chr17	47682698	3'UTR	novel		0.19
BRCA	chr17	47680669	Splice_Region	novel	*877*	0.07
CESC	chr17	47683342	3'UTR	novel		0.11
CESC	chr17	47650057	5'UTR	novel		0.16
CESC	chr17	47668408	Nonsense_Mutation	novel	Q408*	0.45
CESC	chr17	47682681	3'UTR	novel		0.44
CESC	chr17	47682614	3'UTR	novel		0.56
CESC	chr17	47683424	3'UTR	novel		0.47
CESC	chr17	47683346	3'UTR	novel		0.21
COAD	chr17	47674686	Missense_Mutation	NA	V606M	0.42
COAD	chr17	47677095	Missense_Mutation	novel	E691K	0.04
COAD	chr17	47670806	Silent	NA	V507V	0.34
COAD	chr17	47682488	3'UTR	novel		0.31
COAD	chr17	47661126	Missense_Mutation	NA	R215M	0.29
COAD	chr17	47669831	Missense_Mutation	NA	L460I	0.38
COAD	chr17	47678414	Splice_Site	NA	X785_splice	0.25
ESCA	chr17	47673126	Missense_Mutation	NA	L552F	0.11
ESCA	chr17	47652808	Missense_Mutation	novel	I72V	0.07	IBN_N
ESCA	chr17	47673126	Missense_Mutation	NA	L552F	0.22
ESCA	chr17	47661146	Missense_Mutation	novel	V222I	0.38
ESCA	chr17	47673126	Missense_Mutation	NA	L552F	0.08
ESCA	chr17	47682681	3'UTR	novel		0.35
GBM	chr17	47674766	Silent	novel	V632V	0.13
GBM	chr17	47656983	Frame_Shift_Del	NA	*N136Mfs11**	0.31
GBM	chr17	47677034	Silent	novel	A670A	0.43
GBM	chr17	47669739	Frame_Shift_Ins	novel	*W430Mfs8**	0.04
GBM	chr17	47678349	Silent	novel	E763E	0.12
GBM	chr17	47682521	3'UTR	novel		0.06
HNSC	chr17	47665153	Missense_Mutation	novel	K332Q	0.25
HNSC	chr17	47680070	Missense_Mutation	novel	D802H	0.28
HNSC	chr17	47668378	Missense_Mutation	novel	E398Q	0.12
KIRC	chr17	47680030	Missense_Mutation	NA	M788I	0.39
KIRC	chr17	47669807	Silent	NA	L452L	0.4
KIRC	chr17	47678411	Frame_Shift_Ins	novel	*P785Hfs21**	0.1
KIRC	chr17	47680663	Frame_Shift_Ins	novel	*A876Cfs2**	0.05
KIRP	chr17	47650390	Silent	rs768300177	R15R	0.08
KIRP	chr17	47678411	Missense_Mutation	novel	H784L	0.68
KIRP	chr17	47676413	Missense_Mutation	NA	L639F	0.28
KIRP	chr17	47658631	Missense_Mutation	novel	E203K	0.41
LAML	chr17	47665136	Missense_Mutation	novel	L326H	0.2
LIHC	chr17	47674639	Missense_Mutation	novel	N590S	0.14
LIHC	chr17	47680080	Missense_Mutation	NA	A805V	0.07
LUAD	chr17	47680663	Frame_Shift_Ins	novel	*A876Cfs43**	0.11
LUAD	chr17	47670713	Missense_Mutation	NA	S476R	0.2
LUAD	chr17	47674653	Missense_Mutation	novel	V595L	0.28
LUAD	chr17	47674729	Missense_Mutation	NA	G620A	0.06
LUAD	chr17	47678111	Frame_Shift_Ins	novel	*K729Nfs6**	0.22
LUAD	chr17	47656902	Missense_Mutation	novel	A109T	0.28
LUAD	chr17	47657015	Missense_Mutation	NA	M146I	0.12
LUAD	chr17	47682461	3'UTR	novel		0.12
LUAD	chr17	47670815	Silent	NA	L510L	0.09
LUAD	chr17	47661168	Missense_Mutation	novel	P229Q	0.24
LUAD	chr17	47678157	Missense_Mutation	NA	L739V	0.08
LUSC	chr17	47664258	Missense_Mutation	novel	E296K	0.18
LUSC	chr17	47658567	Missense_Mutation	novel	M181I	0.24
LUSC	chr17	47682422	3'UTR	novel		0.22
LUSC	chr17	47668328	Missense_Mutation	novel	R381L	0.26
LUSC	chr17	47677041	In_Frame_Ins	novel	V674dup	0.05
LUSC	chr17	47652754	Missense_Mutation	NA	R54G	0.21	IBN_N
OV	chr17	47677047	Missense_Mutation	novel	G675R	0.16
OV	chr17	47673119	Frame_Shift_Ins	novel	*T551Nfs3**	0.14
OV	chr17	47673120	Frame_Shift_Ins	novel	*L552Pfs68**	0.1
OV	chr17	47669733	Missense_Mutation	novel	T427R	0.06
OV	chr17	47680589	Silent	novel	G850G	0.24
OV	chr17	47678365	Missense_Mutation	NA	Y769H	0.43
OV	chr17	47656864	Missense_Mutation	novel	L96S	0.06	IBN_N
PRAD	chr17	47677060	Missense_Mutation	NA	R679L	0.06
READ	chr17	47680590	Missense_Mutation	rs761508578	R851W	0.4
READ	chr17	47664260	Silent	novel	E296E	0.07
READ	chr17	47669726	Nonsense_Mutation	NA	R425*	0.04
READ	chr17	47669726	Nonsense_Mutation	NA	R425*	0.2
READ	chr17	47676474	Missense_Mutation	novel	N660H	0.09
SARC	chr17	47652763	Missense_Mutation	novel	A57S	0.06	IBN_N
SARC	chr17	47658608	Missense_Mutation	rs747385025	T195M	0.26
SKCM	chr17	47658630	Silent	rs776951725	L202L	0.49
SKCM	chr17	47676452	Silent	rs768003079	P652P	0.33
SKCM	chr17	47680568	Silent	novel	I843I	0.25
SKCM	chr17	47682412	3'UTR	novel		0.56
SKCM	chr17	47652702	Silent	novel	F36F	0.08
SKCM	chr17	47674779	Missense_Mutation	NA	E637K	0.29
SKCM	chr17	47678164	Frame_Shift_Del	novel	*Q741Rfs18**	0.44
SKCM	chr17	47678376	Silent	novel	I772I	0.41
SKCM	chr17	47673157	Nonsense_Mutation	NA	Q563*	0.4
STAD	chr17	47680085	Missense_Mutation	NA	D807N	0.13
STAD	chr17	47650231	5'UTR	rs561959101		0.3
STAD	chr17	47664220	Missense_Mutation	novel	W283S	0.07
STAD	chr17	47677076	Missense_Mutation	NA	N684K	0.16
STAD	chr17	47650417	Missense_Mutation	novel	F24L	0.28	IBN_N
STAD	chr17	47650233	5'UTR	novel		0.26
STAD	chr17	47678330	Missense_Mutation	NA	Y757C	0.35
STAD	chr17	47656945	Missense_Mutation	NA	V123A	0.32
STAD	chr17	47680650	Nonsense_Mutation	novel	K871delinsSS*	0.1
STAD	chr17	47670743	Silent	rs760882449	D486D	0.41
STAD	chr17	47658649	Missense_Mutation	novel	F209V	0.06
STAD	chr17	47673139	Nonsense_Mutation	novel	R557*	0.16
STAD	chr17	47678364	Silent	NA	A768A	0.4
STAD	chr17	47680088	Missense_Mutation	NA	E808K	0.43
STAD	chr17	47656873	Missense_Mutation	NA	L99S	0.3	IBN_N
STAD	chr17	47682488	3'UTR	novel		0.29
STAD	chr17	47656955	Nonsense_Mutation	NA	W126*	0.1
STAD	chr17	47677111	Missense_Mutation	novel	L696P	0.22
STAD	chr17	47673107	Missense_Mutation	NA	A546V	0.2
THCA	chr17	47664255	Frame_Shift_Ins	novel	*I295Tfs6**	0.04
THCA	chr17	47680650	Nonsense_Mutation	novel	K871delinsSS*	0.09
THCA	chr17	47680650	Nonsense_Mutation	novel	K871delinsSS*	0.06
THYM	chr17	47683346	3'UTR	novel		0.07
THYM	chr17	47669747	Missense_Mutation	novel	V432I	0.09
UCEC	chr17	47674725	Missense_Mutation	novel	A619T	0.37
UCEC	chr17	47680608	Missense_Mutation	NA	K857Q	0.38
UCEC	chr17	47669778	Missense_Mutation	novel	A442D	0.4
UCEC	chr17	47674648	Missense_Mutation	novel	R593Q	0.14
UCEC	chr17	47682876	3'UTR	novel		0.36
UCEC	chr17	47682970	3'UTR	novel		0.37
UCEC	chr17	47683293	3'UTR	novel		0.3
UCEC	chr17	47673126	Missense_Mutation	NA	L552F	0.08
UCEC	chr17	47665141	Nonsense_Mutation	novel	Q328*	0.08
UCEC	chr17	47682681	3'UTR	novel		0.54
UCEC	chr17	47682478	3'UTR	novel		0.2
UCEC	chr17	47678082	Missense_Mutation	NA	L714M	0.2
UCEC	chr17	47683185	3'UTR	novel		0.47
UCEC	chr17	47680565	Missense_Mutation	novel	M842I	0.16
UCEC	chr17	47678044	Splice_Site	NA	X702_splice	0.39
UCEC	chr17	47683293	3'UTR	novel		0.54
UCEC	chr17	47682412	3'UTR	novel		0.41
UCEC	chr17	47677094	Silent	rs371651425	D690D	0.33
UCEC	chr17	47682515	3'UTR	novel		0.3
UCEC	chr17	47664167	Silent	novel	I265I	0.1
UCEC	chr17	47650029	5'UTR	novel		0.28
UCEC	chr17	47683293	3'UTR	novel		0.48
UCEC	chr17	47682970	3'UTR	novel		0.31
UCEC	chr17	47682681	3'UTR	novel		0.71
UCEC	chr17	47680630	Nonsense_Mutation	NA	W864*	0.38
UCEC	chr17	47680631	Missense_Mutation	NA	W864C	0.38
UCEC	chr17	47673154	Missense_Mutation	novel	L562F	0.31
UCEC	chr17	47674647	Missense_Mutation	novel	R593W	0.22
UCEC	chr17	47680597	Missense_Mutation	NA	S853L	0.12
UCEC	chr17	47682751	3'UTR	novel		0.36
UCEC	chr17	47673126	Missense_Mutation	NA	L552F	0.13
UCEC	chr17	47668333	Missense_Mutation	NA	R383W	0.38
UCEC	chr17	47682681	3'UTR	novel		0.45
UCEC	chr17	47658590	Missense_Mutation	novel	N189T	0.36
UCEC	chr17	47680641	Nonsense_Mutation	novel	E868*	0.4
UCEC	chr17	47683314	3'UTR	novel		0.85
UCEC	chr17	47683415	3'UTR	novel		0.43
UCEC	chr17	47683598	3'UTR	novel		0.37
UCEC	chr17	47658532	Missense_Mutation	novel	S170T	0.38
UCEC	chr17	47678103	Missense_Mutation	novel	A721T	0.3
UCEC	chr17	47680530	Missense_Mutation	novel	K831E	0.28
UCEC	chr17	47683352	3'UTR	novel		0.27
UCEC	chr17	47683547	3'UTR	novel		0.29
UCEC	chr17	47673057	Silent	novel	Y529Y	0.24
UCEC	chr17	47665110	Silent	novel	G317G	0.28
UCEC	chr17	47668407	Missense_Mutation	novel	I407M	0.41
UCEC	chr17	47676458	Silent	NA	L654L	0.43
UCEC	chr17	47652860	Missense_Mutation	novel	R89Q	0.35	IBN_N
UCEC	chr17	47652856	Nonsense_Mutation	NA	R88*	0.25	IBN_N
UCEC	chr17	47678054	Silent	rs765682540	N704N	0.3
UCEC	chr17	47683272	3'UTR	novel		0.18
UCEC	chr17	47683118	3'UTR	novel		0.5
UCEC	chr17	47683293	3'UTR	novel		0.41
UCEC	chr17	47673496	Missense_Mutation	NA	I568V	0.19
UCEC	chr17	47678378	Missense_Mutation	NA	V773A	0.34
UCEC	chr17	47669679	Missense_Mutation	novel	A409V	0.21
UCEC	chr17	47682655	3'UTR	novel		0.19
UCEC	chr17	47669834	Missense_Mutation	novel	S461G	0.41
UCEC	chr17	47652801	Missense_Mutation	novel	D69E	0.09	IBN_N
UCEC	chr17	47678332	Missense_Mutation	NA	L758M	0.13
UCEC	chr17	47663109	Silent	novel	Q239Q	0.34
UCEC	chr17	47676468	Missense_Mutation	novel	L658I	0.36
UCEC	chr17	47680591	Missense_Mutation	NA	R851Q	0.4
UVM	chr17	47665103	Missense_Mutation	novel	A315V	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.18166
KIRP	AMP	0.6493	0.14801
THCA	DEL	0.002	0.221
UCS	DEL	0.3214	0.19877
UVM	DEL	0.025	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
SARC	0.0028	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.036	Kaplan-Meier Survival Analysis
KIRP	0.00021	Kaplan-Meier Survival Analysis
COAD	0.015	Kaplan-Meier Survival Analysis
READ	0.00049	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
LIHC	0.00016	Kaplan-Meier Survival Analysis
LGG	0.0064	Kaplan-Meier Survival Analysis
THCA	0.043	Kaplan-Meier Survival Analysis
LUAD	0.0015	Kaplan-Meier Survival Analysis
UVM	0.0067	Kaplan-Meier Survival Analysis
OV	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108424 (Gene tree)
Gene ID: 3837
Gene Symbol: KPNB1
Alias: NTF97|IPOB|MGC2155|MGC2156|MGC2157|IMB1|Impnb|IPO1
Full Name: karyopherin subunit beta 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 36,030 bases
Position: chr17:47,649,476-47,685,505
Accession: 6400
RBP type: canonical RBP
Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000464042	IBN_N	PF03810.19	4.4e-12	1	1
ENSP00000290158	IBN_N	PF03810.19	2.6e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580019	KPNB1-208	427	-	-	- (aa)	-	-
ENST00000540627	KPNB1-203	2989	-	ENSP00000438964	731 (aa)	-	Q14974
ENST00000583013	KPNB1-213	742	-	ENSP00000463190	248 (aa)	-	J3QKQ5
ENST00000579901	KPNB1-207	594	-	-	- (aa)	-	-
ENST00000582126	KPNB1-212	653	-	ENSP00000462243	22 (aa)	-	J3KS06
ENST00000535458	KPNB1-202	3163	-	ENSP00000438253	731 (aa)	-	Q14974
ENST00000577875	KPNB1-204	605	-	ENSP00000464200	60 (aa)	-	J3QRG4
ENST00000580573	KPNB1-210	556	-	-	- (aa)	-	-
ENST00000290158	KPNB1-201	6139	-	ENSP00000290158	876 (aa)	-	Q14974
ENST00000578718	KPNB1-206	550	-	-	- (aa)	-	-
ENST00000582097	KPNB1-211	2347	-	ENSP00000463066	690 (aa)	-	J3KTM9
ENST00000583648	KPNB1-214	896	-	ENSP00000464042	148 (aa)	-	J3QR48
ENST00000577918	KPNB1-205	859	-	-	- (aa)	-	-
ENST00000580158	KPNB1-209	603	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108424's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108424	Optic Disk	2E-8	25631615
ENSG00000108424	Optic Disk	2E-8	25631615
ENSG00000108424	Multiple Sclerosis	1E-7	22190364
ENSG00000108424	Spondylitis, Ankylosing	5E-8	21743469

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108424	rs11870935	17	47655239	G	Optic cup area	25631615	[0.0091-0.0169] unit increase	0.013	EFO_0006940
ENSG00000108424	rs11870935	17	47655239	G	Optic cup area	25631615	[0.0091-0.0209] unit increase	0.015	EFO_0006940
ENSG00000108424	rs8078686	17	47658340	T	Total cholesterol levels	29507422	unit increase	0.042	EFO_0004574
ENSG00000108424	rs8078686	17	47658340	T	Total cholesterol levels	29507422	unit increase	0.041	EFO_0004574
ENSG00000108424	rs8078686	17	47658340	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.047	EFO_0004611
ENSG00000108424	rs8078686	17	47658340	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.045	EFO_0004611
ENSG00000108424	rs11870935	17	47655239	A	LDL cholesterol x physical activity interaction (2df test)	30670697			EFO_0004611\|EFO_0003940

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108424's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108424	KPNB1	99	95.205	ENSAPOG00000020572	kpnb1	100	92.922	Acanthochromis_polyacanthus
ENSG00000108424	KPNB1	100	100.000	ENSAMEG00000004613	KPNB1	100	99.171	Ailuropoda_melanoleuca
ENSG00000108424	KPNB1	99	94.521	ENSACIG00000023130	kpnb1	99	92.757	Amphilophus_citrinellus
ENSG00000108424	KPNB1	99	95.205	ENSAOCG00000007048	kpnb1	100	92.922	Amphiprion_ocellaris
ENSG00000108424	KPNB1	99	95.205	ENSAPEG00000008270	kpnb1	100	92.922	Amphiprion_percula
ENSG00000108424	KPNB1	99	95.205	ENSATEG00000015139	kpnb1	100	92.352	Anabas_testudineus
ENSG00000108424	KPNB1	100	100.000	ENSAPLG00000010177	KPNB1	100	94.749	Anas_platyrhynchos
ENSG00000108424	KPNB1	100	100.000	ENSACAG00000007097	KPNB1	100	97.146	Anolis_carolinensis
ENSG00000108424	KPNB1	100	100.000	ENSANAG00000024932	-	99	97.260	Aotus_nancymaae
ENSG00000108424	KPNB1	99	94.521	ENSACLG00000015070	kpnb1	100	92.808	Astatotilapia_calliptera
ENSG00000108424	KPNB1	100	95.000	ENSAMXG00000041903	kpnb1	100	92.922	Astyanax_mexicanus
ENSG00000108424	KPNB1	100	100.000	ENSBTAG00000006586	KPNB1	100	99.429	Bos_taurus
ENSG00000108424	KPNB1	100	71.667	WBGene00002075	imb-1	98	48.303	Caenorhabditis_elegans
ENSG00000108424	KPNB1	100	100.000	ENSCJAG00000007834	KPNB1	100	99.886	Callithrix_jacchus
ENSG00000108424	KPNB1	100	100.000	ENSCAFG00000016678	KPNB1	100	99.429	Canis_familiaris
ENSG00000108424	KPNB1	100	100.000	ENSCAFG00020023205	KPNB1	100	99.429	Canis_lupus_dingo
ENSG00000108424	KPNB1	100	100.000	ENSCHIG00000014896	KPNB1	100	99.429	Capra_hircus
ENSG00000108424	KPNB1	100	100.000	ENSTSYG00000014472	KPNB1	99	97.374	Carlito_syrichta
ENSG00000108424	KPNB1	100	100.000	ENSCAPG00000014185	KPNB1	100	99.051	Cavia_aperea
ENSG00000108424	KPNB1	100	100.000	ENSCPOG00000006566	KPNB1	100	99.087	Cavia_porcellus
ENSG00000108424	KPNB1	100	100.000	ENSCCAG00000018551	-	100	79.725	Cebus_capucinus
ENSG00000108424	KPNB1	100	100.000	ENSCCAG00000029263	-	99	92.825	Cebus_capucinus
ENSG00000108424	KPNB1	100	100.000	ENSCATG00000037124	KPNB1	100	100.000	Cercocebus_atys
ENSG00000108424	KPNB1	100	100.000	ENSCLAG00000017091	KPNB1	100	98.973	Chinchilla_lanigera
ENSG00000108424	KPNB1	100	100.000	ENSCSAG00000002605	KPNB1	100	100.000	Chlorocebus_sabaeus
ENSG00000108424	KPNB1	95	100.000	ENSCHOG00000010604	KPNB1	73	100.000	Choloepus_hoffmanni
ENSG00000108424	KPNB1	100	100.000	ENSCPBG00000027423	KPNB1	94	98.146	Chrysemys_picta_bellii
ENSG00000108424	KPNB1	100	66.667	ENSCING00000004639	-	99	64.424	Ciona_intestinalis
ENSG00000108424	KPNB1	100	63.378	ENSCSAVG00000008624	-	100	62.147	Ciona_savignyi
ENSG00000108424	KPNB1	100	100.000	ENSCANG00000013489	KPNB1	91	97.820	Colobus_angolensis_palliatus
ENSG00000108424	KPNB1	100	100.000	ENSCGRG00001016042	Kpnb1	100	99.315	Cricetulus_griseus_chok1gshd
ENSG00000108424	KPNB1	100	100.000	ENSCGRG00000013910	Kpnb1	100	99.288	Cricetulus_griseus_crigri
ENSG00000108424	KPNB1	100	93.333	ENSCSEG00000007991	kpnb1	100	90.141	Cynoglossus_semilaevis
ENSG00000108424	KPNB1	100	91.892	ENSCVAG00000012454	-	90	92.547	Cyprinodon_variegatus
ENSG00000108424	KPNB1	99	95.205	ENSDARG00000104889	kpnb1	100	92.123	Danio_rerio
ENSG00000108424	KPNB1	98	69.492	FBgn0262743	Fs(2)Ket	99	61.644	Drosophila_melanogaster
ENSG00000108424	KPNB1	100	83.333	ENSEBUG00000013869	kpnb1	98	82.135	Eptatretus_burgeri
ENSG00000108424	KPNB1	100	100.000	ENSEASG00005000805	KPNB1	100	99.429	Equus_asinus_asinus
ENSG00000108424	KPNB1	100	100.000	ENSECAG00000014560	KPNB1	100	99.429	Equus_caballus
ENSG00000108424	KPNB1	100	100.000	ENSEEUG00000005046	KPNB1	88	98.995	Erinaceus_europaeus
ENSG00000108424	KPNB1	100	95.000	ENSELUG00000015847	kpnb1	100	92.808	Esox_lucius
ENSG00000108424	KPNB1	100	100.000	ENSFCAG00000023994	KPNB1	100	99.429	Felis_catus
ENSG00000108424	KPNB1	100	100.000	ENSFDAG00000019923	KPNB1	100	99.170	Fukomys_damarensis
ENSG00000108424	KPNB1	99	94.521	ENSFHEG00000020199	kpnb1	100	92.237	Fundulus_heteroclitus
ENSG00000108424	KPNB1	99	95.205	ENSGMOG00000011607	kpnb1	99	88.128	Gadus_morhua
ENSG00000108424	KPNB1	100	100.000	ENSGALG00000036962	KPNB1	100	97.717	Gallus_gallus
ENSG00000108424	KPNB1	100	93.333	ENSGAFG00000000783	kpnb1	100	92.009	Gambusia_affinis
ENSG00000108424	KPNB1	99	95.205	ENSGACG00000014765	kpnb1	100	88.475	Gasterosteus_aculeatus
ENSG00000108424	KPNB1	100	100.000	ENSGAGG00000023737	KPNB1	92	97.860	Gopherus_agassizii
ENSG00000108424	KPNB1	100	100.000	ENSGGOG00000008089	KPNB1	100	100.000	Gorilla_gorilla
ENSG00000108424	KPNB1	99	94.521	ENSHBUG00000016826	kpnb1	100	92.808	Haplochromis_burtoni
ENSG00000108424	KPNB1	100	100.000	ENSHGLG00000014138	KPNB1	100	99.201	Heterocephalus_glaber_female
ENSG00000108424	KPNB1	100	100.000	ENSHGLG00100006572	KPNB1	100	99.170	Heterocephalus_glaber_male
ENSG00000108424	KPNB1	100	93.333	ENSHCOG00000002084	kpnb1	100	90.868	Hippocampus_comes
ENSG00000108424	KPNB1	100	95.000	ENSIPUG00000012402	kpnb1	95	88.528	Ictalurus_punctatus
ENSG00000108424	KPNB1	100	100.000	ENSSTOG00000007896	KPNB1	100	99.429	Ictidomys_tridecemlineatus
ENSG00000108424	KPNB1	100	100.000	ENSJJAG00000010909	Kpnb1	100	99.087	Jaculus_jaculus
ENSG00000108424	KPNB1	99	95.205	ENSKMAG00000001547	kpnb1	100	91.895	Kryptolebias_marmoratus
ENSG00000108424	KPNB1	99	94.521	ENSLBEG00000025794	kpnb1	99	91.111	Labrus_bergylta
ENSG00000108424	KPNB1	100	100.000	ENSLACG00000017620	KPNB1	99	94.293	Latimeria_chalumnae
ENSG00000108424	KPNB1	100	95.000	ENSLOCG00000013753	kpnb1	100	93.493	Lepisosteus_oculatus
ENSG00000108424	KPNB1	100	100.000	ENSLAFG00000001328	KPNB1	100	94.064	Loxodonta_africana
ENSG00000108424	KPNB1	100	100.000	ENSMFAG00000030197	KPNB1	100	100.000	Macaca_fascicularis
ENSG00000108424	KPNB1	100	100.000	ENSMMUG00000019760	KPNB1	99	98.286	Macaca_mulatta
ENSG00000108424	KPNB1	100	100.000	ENSMNEG00000040927	KPNB1	100	100.000	Macaca_nemestrina
ENSG00000108424	KPNB1	100	100.000	ENSMLEG00000038185	KPNB1	96	100.000	Mandrillus_leucophaeus
ENSG00000108424	KPNB1	99	95.205	ENSMAMG00000011036	kpnb1	100	92.922	Mastacembelus_armatus
ENSG00000108424	KPNB1	99	94.521	ENSMZEG00005004564	kpnb1	100	92.808	Maylandia_zebra
ENSG00000108424	KPNB1	100	98.333	ENSMGAG00000002770	-	100	98.137	Meleagris_gallopavo
ENSG00000108424	KPNB1	100	100.000	ENSMAUG00000006211	Kpnb1	100	99.315	Mesocricetus_auratus
ENSG00000108424	KPNB1	100	100.000	ENSMICG00000012059	KPNB1	84	99.658	Microcebus_murinus
ENSG00000108424	KPNB1	100	100.000	ENSMOCG00000003683	Kpnb1	100	99.315	Microtus_ochrogaster
ENSG00000108424	KPNB1	100	91.892	ENSMMOG00000012713	-	87	92.547	Mola_mola
ENSG00000108424	KPNB1	100	100.000	ENSMODG00000012505	KPNB1	100	98.402	Monodelphis_domestica
ENSG00000108424	KPNB1	99	95.205	ENSMALG00000000863	kpnb1	100	93.037	Monopterus_albus
ENSG00000108424	KPNB1	100	100.000	MGP_CAROLIEiJ_G0017050	Kpnb1	100	99.148	Mus_caroli
ENSG00000108424	KPNB1	100	100.000	ENSMUSG00000001440	Kpnb1	100	99.201	Mus_musculus
ENSG00000108424	KPNB1	100	100.000	ENSMPUG00000015220	KPNB1	100	98.404	Mustela_putorius_furo
ENSG00000108424	KPNB1	100	100.000	ENSMLUG00000014522	KPNB1	100	94.084	Myotis_lucifugus
ENSG00000108424	KPNB1	100	100.000	ENSNGAG00000017610	Kpnb1	100	99.288	Nannospalax_galili
ENSG00000108424	KPNB1	99	94.521	ENSNBRG00000019305	kpnb1	100	92.808	Neolamprologus_brichardi
ENSG00000108424	KPNB1	100	100.000	ENSNLEG00000001446	KPNB1	100	100.000	Nomascus_leucogenys
ENSG00000108424	KPNB1	100	100.000	ENSMEUG00000014284	KPNB1	100	92.808	Notamacropus_eugenii
ENSG00000108424	KPNB1	100	100.000	ENSODEG00000017287	KPNB1	100	98.744	Octodon_degus
ENSG00000108424	KPNB1	99	94.521	ENSONIG00000009269	kpnb1	100	92.922	Oreochromis_niloticus
ENSG00000108424	KPNB1	100	100.000	ENSOCUG00000015425	KPNB1	100	99.429	Oryctolagus_cuniculus
ENSG00000108424	KPNB1	99	95.205	ENSORLG00000019936	kpnb1	100	92.808	Oryzias_latipes
ENSG00000108424	KPNB1	99	95.205	ENSORLG00020021181	kpnb1	100	92.808	Oryzias_latipes_hni
ENSG00000108424	KPNB1	99	95.205	ENSORLG00015012177	kpnb1	100	92.694	Oryzias_latipes_hsok
ENSG00000108424	KPNB1	99	95.205	ENSOMEG00000021022	kpnb1	100	92.922	Oryzias_melastigma
ENSG00000108424	KPNB1	100	100.000	ENSOGAG00000006153	KPNB1	100	99.543	Otolemur_garnettii
ENSG00000108424	KPNB1	100	100.000	ENSOARG00000008469	KPNB1	99	98.361	Ovis_aries
ENSG00000108424	KPNB1	100	100.000	ENSPPAG00000028842	KPNB1	100	100.000	Pan_paniscus
ENSG00000108424	KPNB1	100	100.000	ENSPPRG00000022879	KPNB1	99	96.785	Panthera_pardus
ENSG00000108424	KPNB1	100	100.000	ENSPTIG00000006870	KPNB1	99	96.785	Panthera_tigris_altaica
ENSG00000108424	KPNB1	100	100.000	ENSPTRG00000009333	KPNB1	100	100.000	Pan_troglodytes
ENSG00000108424	KPNB1	100	100.000	ENSPANG00000022099	KPNB1	100	100.000	Papio_anubis
ENSG00000108424	KPNB1	100	95.000	ENSPKIG00000017563	kpnb1	100	93.037	Paramormyrops_kingsleyae
ENSG00000108424	KPNB1	100	100.000	ENSPSIG00000009775	KPNB1	100	98.339	Pelodiscus_sinensis
ENSG00000108424	KPNB1	100	91.667	ENSPMGG00000001041	kpnb1	93	88.141	Periophthalmus_magnuspinnatus
ENSG00000108424	KPNB1	100	100.000	ENSPEMG00000017783	Kpnb1	100	99.315	Peromyscus_maniculatus_bairdii
ENSG00000108424	KPNB1	99	91.781	ENSPMAG00000007117	kpnb1	99	86.105	Petromyzon_marinus
ENSG00000108424	KPNB1	100	100.000	ENSPCIG00000001034	KPNB1	100	98.402	Phascolarctos_cinereus
ENSG00000108424	KPNB1	100	93.333	ENSPFOG00000009014	kpnb1	100	92.009	Poecilia_formosa
ENSG00000108424	KPNB1	100	93.333	ENSPLAG00000010922	kpnb1	100	92.009	Poecilia_latipinna
ENSG00000108424	KPNB1	100	91.892	ENSPMEG00000001107	-	86	92.547	Poecilia_mexicana
ENSG00000108424	KPNB1	100	93.333	ENSPREG00000012268	kpnb1	100	92.009	Poecilia_reticulata
ENSG00000108424	KPNB1	100	100.000	ENSPPYG00000025935	KPNB1	100	99.543	Pongo_abelii
ENSG00000108424	KPNB1	95	100.000	ENSPCAG00000002526	KPNB1	78	82.667	Procavia_capensis
ENSG00000108424	KPNB1	100	100.000	ENSPCOG00000026259	KPNB1	100	99.658	Propithecus_coquereli
ENSG00000108424	KPNB1	100	100.000	ENSPVAG00000004910	KPNB1	100	98.973	Pteropus_vampyrus
ENSG00000108424	KPNB1	99	94.521	ENSPNYG00000017703	kpnb1	96	93.367	Pundamilia_nyererei
ENSG00000108424	KPNB1	100	95.000	ENSPNAG00000024047	kpnb1	98	84.765	Pygocentrus_nattereri
ENSG00000108424	KPNB1	100	100.000	ENSRNOG00000009275	Kpnb1	100	99.201	Rattus_norvegicus
ENSG00000108424	KPNB1	100	100.000	ENSRBIG00000002254	KPNB1	99	99.772	Rhinopithecus_bieti
ENSG00000108424	KPNB1	100	100.000	ENSRROG00000030419	KPNB1	99	99.538	Rhinopithecus_roxellana
ENSG00000108424	KPNB1	98	47.541	YLR347C	KAP95	99	33.788	Saccharomyces_cerevisiae
ENSG00000108424	KPNB1	100	100.000	ENSSBOG00000030025	KPNB1	94	100.000	Saimiri_boliviensis_boliviensis
ENSG00000108424	KPNB1	100	100.000	ENSSHAG00000018214	KPNB1	100	98.111	Sarcophilus_harrisii
ENSG00000108424	KPNB1	100	95.000	ENSSFOG00015020000	kpnb1	100	93.607	Scleropages_formosus
ENSG00000108424	KPNB1	99	95.205	ENSSDUG00000016218	kpnb1	100	93.151	Seriola_dumerili
ENSG00000108424	KPNB1	99	95.205	ENSSLDG00000021549	kpnb1	97	93.124	Seriola_lalandi_dorsalis
ENSG00000108424	KPNB1	100	100.000	ENSSPUG00000017799	KPNB1	100	97.489	Sphenodon_punctatus
ENSG00000108424	KPNB1	99	95.205	ENSSPAG00000019346	kpnb1	100	92.922	Stegastes_partitus
ENSG00000108424	KPNB1	100	100.000	ENSSSCG00000017514	KPNB1	100	99.201	Sus_scrofa
ENSG00000108424	KPNB1	100	100.000	ENSTGUG00000003387	KPNB1	100	92.883	Taeniopygia_guttata
ENSG00000108424	KPNB1	100	93.333	ENSTRUG00000000542	kpnb1	100	90.297	Takifugu_rubripes
ENSG00000108424	KPNB1	100	93.333	ENSTNIG00000019617	-	99	92.737	Tetraodon_nigroviridis
ENSG00000108424	KPNB1	99	94.521	ENSTNIG00000006494	kpnb1	100	90.525	Tetraodon_nigroviridis
ENSG00000108424	KPNB1	100	100.000	ENSTTRG00000004682	KPNB1	100	99.288	Tursiops_truncatus
ENSG00000108424	KPNB1	100	100.000	ENSUAMG00000025344	KPNB1	99	99.429	Ursus_americanus
ENSG00000108424	KPNB1	100	100.000	ENSUMAG00000016471	KPNB1	98	98.140	Ursus_maritimus
ENSG00000108424	KPNB1	100	100.000	ENSVPAG00000003675	KPNB1	100	84.589	Vicugna_pacos
ENSG00000108424	KPNB1	100	100.000	ENSVVUG00000003085	KPNB1	100	99.429	Vulpes_vulpes
ENSG00000108424	KPNB1	100	96.667	ENSXETG00000014717	kpnb1	100	95.091	Xenopus_tropicalis
ENSG00000108424	KPNB1	100	91.892	ENSXCOG00000001578	-	88	92.547	Xiphophorus_couchianus
ENSG00000108424	KPNB1	100	93.333	ENSXMAG00000018792	kpnb1	100	92.123	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	9405152.10523667.11024021.11311162.11971900.12372823.15282309.15494309.15507604.15870280.16314522.19680228.20701745.20818336.22084111.22500989.24169621.26195665.26496610.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005635	nuclear envelope	22701565.	IDA	Component
GO:0005643	nuclear pore	7627554.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006309	apoptotic DNA fragmentation	-	TAS	Process
GO:0006606	protein import into nucleus	7615630.15964792.	IDA	Process
GO:0006607	NLS-bearing protein import into nucleus	21873635.	IBA	Process
GO:0006610	ribosomal protein import into nucleus	21873635.	IBA	Process
GO:0006610	ribosomal protein import into nucleus	9687515.	IDA	Process
GO:0007079	mitotic chromosome movement towards spindle pole	23783028.	IMP	Process
GO:0007080	mitotic metaphase plate congression	23783028.	IMP	Process
GO:0008139	nuclear localization sequence binding	21873635.	IBA	Function
GO:0008270	zinc ion binding	7615630.	TAS	Function
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0019054	modulation by virus of host process	-	TAS	Process
GO:0019899	enzyme binding	22701565.	IPI	Function
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0030953	astral microtubule organization	23783028.	IMP	Process
GO:0031291	Ran protein signal transduction	23783028.	IMP	Process
GO:0031965	nuclear membrane	21873635.	IBA	Component
GO:0031965	nuclear membrane	-	IDA	Component
GO:0034399	nuclear periphery	21873635.	IBA	Component
GO:0035580	specific granule lumen	-	TAS	Component
GO:0040001	establishment of mitotic spindle localization	23783028.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043657	host cell	-	IEA	Component
GO:0045184	establishment of protein localization	23783028.	IMP	Process
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	Process
GO:0051879	Hsp90 protein binding	-	IEA	Function
GO:0061676	importin-alpha family protein binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071782	endoplasmic reticulum tubular network	22701565.	IDA	Component
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:0090307	mitotic spindle assembly	23783028.	IMP	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

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Phenotypes

GWAS

PPI

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Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.