EuRBPDB

Ensembl ID

ENSG00000108424 (Gene tree)

Gene ID

3837

Gene Symbol

KPNB1

Alias

NTF97|IPOB|MGC2155|MGC2156|MGC2157|IMB1|Impnb|IPO1

Full Name

karyopherin subunit beta 1

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

36,030 bases

Position

chr17:47,649,476-47,685,505

Accession

6400

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]