EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22129993Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.Cell Cycle2011 Dec 1Balliet RMdoi: 10.4161/cc.10.23.18254
29277826Prognostic Significance of Mitochondrial Transcription Factor A Expression in Patients with Right- or Left-sided Colorectal Cancer.Anticancer Res2018 JanKatsuki T-
27878239AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway.Int J Oncol2017 JanMorishita Mdoi: 10.3892/ijo.2016.3775
26307971Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy.Int J Mol Sci2015 Aug 20Kohno Kdoi: 10.3390/ijms160819836.
22098591Mitochondrial transcription factor A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer.Cancer Sci2012 FebKurita Tdoi: 10.1111/j.1349-7006.2011.02156.x
27779689Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptorpositive breast cancer.Mol Med Rep2016 DecGao Wdoi: 10.3892/mmr.2016.5881
21453679Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth.Biochem Biophys Res Commun2011 Apr 29Han Bdoi: 10.1016/j.bbrc.2011.03.114
28126676MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM).Biomed Pharmacother2017 AprFan Xdoi: 10.1016/j.biopha.2017.01.058
24367550Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer.PLoS One2013 Dec 18Peng Hdoi: 10.1371/journal.pone.0082739
25556274The inhibitory role of miR-214 in cervical cancer cells through directly targeting mitochondrial transcription factor A (TFAM).Eur J Gynaecol Oncol2014Wen Z-
27878255Roles of mitochondrial transcription factor A and microRNA5903p in the development of colon cancer.Mol Med Rep2016 DecWu Kdoi: 10.3892/mmr.2016.5955
27843028Association of a TFAM haplotype with aggressive prostate cancer in overweight or obese Mexican Mestizo men.Urol Oncol2017 MarGranados JBdoi: 10.1016/j.urolonc.2016.10.011
28440425Mitochondrial transcription factor A (TFAM) is upregulated in glioma.Mol Med Rep2017 JunLee Hdoi: 10.3892/mmr.2017.6467
28639399TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition.J Cell Biochem2018 JanYao Jdoi: 10.1002/jcb.26231
28438434Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma.J Formos Med Assoc2018 MarLai WTdoi: 10.1016/j.jfma.2017.04.003

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1058388821Splice_SiteNAX147_splice0.32
BLCAchr1058394400Frame_Shift_DelnovelD194Lfs*20.04
BLCAchr1058386235Silentrs748212315P39P0.29
CESCchr1058390768Missense_MutationnovelL149I0.45
CESCchr1058388702SilentnovelQ108Q0.49
CESCchr1058395065Missense_MutationnovelE244D0.14
CESCchr1058388761Missense_MutationnovelS128F0.16
COADchr10583951363'UTRnovel0.44
COADchr1058388715Missense_MutationNAE113Q0.34
COADchr10583951483'UTRnovel0.32
COADchr1058385572Missense_MutationNAG9R0.3
COADchr1058394928Splice_RegionNAL199L0.08
GBMchr1058388733Nonsense_MutationnovelE119*0.47
GBMchr1058394983Missense_MutationnovelS217Y0.26
GBMchr1058386322Missense_MutationnovelF68L0.07
GBMchr1058386271Missense_MutationnovelK51N0.19
HNSCchr1058388801Missense_MutationnovelK141N0.22
LAMLchr1058395031Missense_Mutationrs375752119R233H0.28
LIHCchr10583854975'UTRnovel0.39
LUADchr1058395028Missense_MutationnovelR232P0.09
LUADchr1058388689Missense_MutationnovelR104M0.27
LUADchr10583951693'UTRnovel0.29
LUSCchr1058386317Missense_Mutationrs138243284I67V0.17
LUSCchr10583951083'UTRnovel0.17
LUSCchr1058394366SilentNAL182L0.07
LUSCchr1058388188Splice_SiteNAX74_splice0.38
LUSCchr1058388765Missense_MutationnovelL129F0.23
PAADchr10583951483'UTRnovel0.11
PRADchr1058388807Missense_Mutationrs553009666M143I0.35
READchr1058394978Missense_MutationNAM215I0.37
SKCMchr1058394952Missense_MutationNAD207N0.47
SKCMchr1058390798Missense_MutationNAR159C0.57
STADchr10583950773'UTRnovel0.14
STADchr10583950793'UTRnovel0.14
STADchr1058394954Silentrs751007038D207D0.17
STADchr1058394395Frame_Shift_DelnovelS193*0.17
STADchr1058390799Missense_MutationnovelR159L0.22
UCECchr1058395027Missense_Mutationrs774009575R232C0.38
UCECchr1058394999Missense_MutationNAM222I0.42
UCECchr1058388772Nonsense_MutationnovelE132*0.29
UCECchr10583951693'UTRnovel0.33
UCECchr1058395049Missense_MutationnovelR239Q0.28
UCECchr10583951083'UTRnovel0.05
UCECchr1058390798Missense_MutationNAR159C0.11
UCECchr1058386321Missense_MutationnovelF68C0.41
UCECchr1058385629Nonsense_MutationNAR28*0.19
UCECchr10583952743'UTRnovel0.7
UCECchr1058388733Nonsense_MutationnovelE119*0.33
UCECchr1058388772Nonsense_MutationnovelE132*0.47
UCECchr1058390798Missense_MutationNAR159C0.51
UCECchr1058388254Frame_Shift_InsnovelI98Nfs*70.53
UCECchr1058394372SilentnovelT184T0.39
UCECchr1058395049Missense_MutationnovelR239Q0.37
UCECchr10583952183'UTRnovel0.27
UCECchr1058388222Missense_MutationnovelA85T0.35
UCECchr1058394959Missense_MutationnovelT209N0.25
UCECchr10583952193'UTRnovel0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.08890.19593
ESCADEL0.18480.039099
KIRPDEL0.0660.1975
UCECDEL0.07420.011507

Survival Analysis
CancerP-value Q-value
THYM0.033

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.0003

Kaplan-Meier Survival Analysis

MESO0.05

Kaplan-Meier Survival Analysis

UCS0.048

Kaplan-Meier Survival Analysis

SKCM0.0075

Kaplan-Meier Survival Analysis

PRAD0.025

Kaplan-Meier Survival Analysis

KIRP0.0063

Kaplan-Meier Survival Analysis

COAD0.031

Kaplan-Meier Survival Analysis

PAAD0.014

Kaplan-Meier Survival Analysis

UCEC0.039

Kaplan-Meier Survival Analysis

GBM0.00086

Kaplan-Meier Survival Analysis

LIHC0.015

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.037

Kaplan-Meier Survival Analysis

LUAD0.017

Kaplan-Meier Survival Analysis

OV0.0016

Kaplan-Meier Survival Analysis

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000108064 (Gene tree)
Gene ID
7019
Gene Symbol
TFAM
Alias
TCF6|TCF6L2
Full Name
transcription factor A, mitochondrial
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
14,209 bases
Position
chr10:58,385,022-58,399,230
Accession
11741
RBP type
non-canonical RBP
Summary
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21920408The role of TFAM-associated proteins in mitochondrial RNA metabolism.Biochim Biophys Acta2012 MayUchiumi Tdoi: 10.1016/j.bbagen.2011.08.014
27814609Mitochondrial nucleic acid binding proteins associated with diseases.Front Biosci (Landmark Ed)2017 Jan 1Uchiumi T-
19624753DNA conformation-dependent activities of human mitochondrial RNA polymerase.Genes Cells2009 AugFukuoh Adoi: 10.1111/j.1365-2443.2009.01328.x
27903899Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.Nucleic Acids Res2017 Jan 25Ramachandran Adoi: 10.1093/nar/gkw1157
30556250Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-kB and p53.J Cell Biochem2019 AprZhang Ydoi: 10.1002/jcb.27982
7559632Identification by in Organello footprinting of protein contact sites and of single-stranded DNA sequences in the regulatory region of rat mitochondrial DNA. Protein binding sites and single-stranded DNA regions in isolated rat liver mitochondria.J Biol Chem1995 Oct 20Cantatore P-
8524270Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA.Mol Cell Biol1995 DecAntoshechkin I-
8473311In organello footprinting. Analysis of protein binding at regulatory regions in bovine mitochondrial DNA.J Biol Chem1993 Apr 25Ghivizzani SC-
15684387Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.Mol Cell Biol2005 FebGleyzer N-
19424428Ancient mtDNA genetic variants modulate mtDNA transcription and replication.PLoS Genet2009 MaySuissa Sdoi: 10.1371/journal.pgen.1000474
17557812Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.Nucleic Acids Res2007Cotney J-
17337445Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.J Biol Chem2007 Apr 27Wang Z-
25612828Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation.Sci Rep2015 Jan 23Yang RFdoi: 10.1038/srep07990.
26545237Mitochondrial Transcription Factor A (TFAM) Binds to RNA Containing 4-Way Junctions and Mitochondrial tRNA.PLoS One2015 Nov 6Brown TAdoi: 10.1371/journal.pone.0142436
25800739A model for transcription initiation in human mitochondria.Nucleic Acids Res2015 Apr 20Morozov YIdoi: 10.1093/nar/gkv235
30190598Structural basis of mitochondrial transcription.Nat Struct Mol Biol2018 SepHillen HSdoi: 10.1038/s41594-018-0122-9
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000373899TFAM-2021121--- (aa)--
ENST00000487519TFAM-2045414-ENSP00000420588246 (aa)-Q00059
ENST00000373895TFAM-201973-ENSP00000363002214 (aa)-Q00059
ENST00000395377TFAM-203663XM_011540121ENSP00000378776219 (aa)XP_011538423H7BYN3
Gene Model
Click here to download ENSG00000108064's gene model file
Pathways
Pathway IDPathway NameSource
hsa04371Apelin signaling pathwayKEGG
hsa05016Huntington diseaseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000108064Erythrocyte Indices1.7820000E-005-
ENSG00000108064Erythrocyte Indices1.7770000E-005-
ENSG00000108064Refraction, Ocular2E-1323396134
ENSG00000108064Body Height6E-623456168
ENSG00000108064Migraine Disorders2E-623793025
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108064's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001018mitochondrial promoter sequence-specific DNA binding19304746.IDAFunction
GO:0001223transcription coactivator binding-IEAFunction
GO:0003682chromatin binding18063578.IDAFunction
GO:0003700DNA-binding transcription factor activity22037171.IMPFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding12897151.25416956.29445193.29568061.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005759mitochondrial matrix29445193.IDAComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005829cytosol-TASComponent
GO:0006390mitochondrial transcription22037171.IMPProcess
GO:0006391transcription initiation from mitochondrial promoter20410300.IDAProcess
GO:0006391transcription initiation from mitochondrial promoter-TASProcess
GO:0007005mitochondrion organization-TASProcess
GO:0008301DNA binding, bending22037171.IDAFunction
GO:0031072heat shock protein binding-IEAFunction
GO:0032991protein-containing complex29445193.IDAComponent
GO:0033108mitochondrial respiratory chain complex assembly-IEAProcess
GO:0042645mitochondrial nucleoid18063578.IDAComponent
GO:0043565sequence-specific DNA binding29445193.IDAFunction
GO:0045893positive regulation of transcription, DNA-templated20410300.IDAProcess
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