EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr10101782335Missense_MutationNAF114C0.23Nucleoplasmin
BLCAchr10101783277Missense_Mutationrs773885926F38L0.42Nucleoplasmin
BLCAchr10101782581Missense_MutationnovelG74A0.16Nucleoplasmin
BLCAchr10101783355Missense_MutationnovelL12F0.15
BRCAchr10101782334Missense_MutationnovelF114L0.25Nucleoplasmin
BRCAchr10101782484SilentNAQ106Q0.62
CHOLchr10101782483Missense_MutationnovelP107S0.58Nucleoplasmin
COADchr10101783277Missense_Mutationrs773885926F38L0.31Nucleoplasmin
COADchr10101782586Silentrs769914016T72T0.23
COADchr10101783337SilentnovelT18T0.33
COADchr10101782487SilentnovelC105C0.12
GBMchr101017815633'UTRnovel0.2
HNSCchr10101782585Missense_Mutationrs745777576E73K0.07Nucleoplasmin
HNSCchr10101782282Missense_MutationnovelR132G0.28Nucleoplasmin
LAMLchr10101782282Missense_MutationNAR132W0.07Nucleoplasmin
LAMLchr10101781819Nonsense_MutationnovelE152*0.03
LUADchr10101782850Missense_MutationNAA65S0.31Nucleoplasmin
OVchr10101782507Missense_Mutationrs750952873A99T0.32Nucleoplasmin
PAADchr10101782482Missense_MutationnovelP107L0.18Nucleoplasmin
PRADchr10101781794Missense_MutationnovelE160G0.14
SKCMchr101017815943'UTRnovel0.32
SKCMchr10101782327Nonsense_MutationnovelQ117*0.14Nucleoplasmin
STADchr10101783351Nonsense_MutationNAQ14*0.37
STADchr10101781764Missense_Mutationrs774468944P170L0.27
THCAchr10101782308Missense_MutationNAR123L0.2Nucleoplasmin
UCECchr10101782520Silentrs775197678I94I0.33
UCECchr101017816103'UTRrs5297479950.43
UCECchr10101782532Silentrs752340132D90D0.26
UCECchr10101781745Frame_Shift_InsnovelR177Qfs*210.4
UCECchr10101781793Missense_MutationnovelE160D0.16
UCECchr10101781799SilentnovelS158S0.13
UCECchr10101782299Missense_Mutationrs771883465S126L0.32Nucleoplasmin
UCECchr10101782520Silentrs775197678I94I0.37
UCECchr101017815653'UTRnovel0.23
UCECchr10101782351Missense_MutationnovelL109I0.24Nucleoplasmin
UCECchr10101782905SilentnovelH46H0.21
UCECchr10101781851Missense_MutationnovelT141M0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
CHOLDEL0.22220.048655
COADDEL0.17749.4741e-07
MESODEL0.27590.00015289
OVDEL0.38865.3759e-12
PAADDEL0.13590.169
READDEL0.24240.014135
THCADEL0.0140.011063
THYMDEL0.03250.10563
UCSDEL0.30360.1218

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

STAD0.038

Kaplan-Meier Survival Analysis

MESO0.0003

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

HNSC0.00072

Kaplan-Meier Survival Analysis

SKCM0.0084

Kaplan-Meier Survival Analysis

PRAD0.02

Kaplan-Meier Survival Analysis

KIRP0.0011

Kaplan-Meier Survival Analysis

PAAD0.022

Kaplan-Meier Survival Analysis

LIHC0.018

Kaplan-Meier Survival Analysis

LGG0.00013

Kaplan-Meier Survival Analysis

LUAD0.021

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000107833 (Gene tree)
Gene ID
10360
Gene Symbol
NPM3
Alias
N
Full Name
nucleophosmin/nucleoplasmin 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
2,089 bases
Position
chr10:101,781,325-101,783,413
Accession
7931
RBP type
canonical RBP
Summary
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000359128NucleoplasminPF03066.154.6e-3511
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22362753Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.Nucleic Acids Res2012 JunOkuwaki Mdoi: 10.1093/nar/gks162
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000474993NPM3-204755--- (aa)--
ENST00000468544NPM3-203393--- (aa)--
ENST00000462391NPM3-202481--- (aa)--
ENST00000370110NPM3-201877-ENSP00000359128178 (aa)-O75607
Gene Model
Click here to download ENSG00000107833's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107833's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000107833NPM37038.889ENSG00000158806NPM28436.145
ENSG00000107833NPM36244.545ENSG00000181163NPM15145.614
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000107833NPM37950.350ENSAPOG00000013083npm36652.778Acanthochromis_polyacanthus
ENSG00000107833NPM310096.067ENSAMEG00000017639-10096.067Ailuropoda_melanoleuca
ENSG00000107833NPM38572.549ENSAMEG00000019414-9072.549Ailuropoda_melanoleuca
ENSG00000107833NPM36150.909ENSACIG00000022586npm36751.852Amphilophus_citrinellus
ENSG00000107833NPM37948.936ENSAOCG00000009376npm38748.936Amphiprion_ocellaris
ENSG00000107833NPM37948.936ENSAPEG00000015863npm38748.936Amphiprion_percula
ENSG00000107833NPM37949.296ENSATEG00000022752npm38749.296Anabas_testudineus
ENSG00000107833NPM37665.926ENSAPLG00000010935NPM38665.926Anas_platyrhynchos
ENSG00000107833NPM35866.019ENSACAG00000011936NPM38562.143Anolis_carolinensis
ENSG00000107833NPM310097.191ENSANAG00000027082-10097.191Aotus_nancymaae
ENSG00000107833NPM38392.517ENSANAG00000023832-6392.537Aotus_nancymaae
ENSG00000107833NPM39574.556ENSANAG00000023070-8083.582Aotus_nancymaae
ENSG00000107833NPM310080.337ENSANAG00000033290-9477.381Aotus_nancymaae
ENSG00000107833NPM37953.191ENSACLG00000007854npm38753.191Astatotilapia_calliptera
ENSG00000107833NPM36055.660ENSAMXG00000039828npm35655.046Astyanax_mexicanus
ENSG00000107833NPM39990.395ENSBTAG00000016335NPM39488.623Bos_taurus
ENSG00000107833NPM310094.944ENSCJAG00000017650NPM39495.238Callithrix_jacchus
ENSG00000107833NPM39494.611ENSCAFG00000009919NPM38792.090Canis_familiaris
ENSG00000107833NPM39494.611ENSCAFG00020009185NPM39992.090Canis_lupus_dingo
ENSG00000107833NPM39961.364ENSCHIG00000016052-9262.048Capra_hircus
ENSG00000107833NPM39990.395ENSCHIG00000024055-9488.623Capra_hircus
ENSG00000107833NPM39453.892ENSCAPG00000016606NPM39451.190Cavia_aperea
ENSG00000107833NPM39489.286ENSCPOG00000006301NPM39587.500Cavia_porcellus
ENSG00000107833NPM39495.238ENSCCAG00000031043-9495.238Cebus_capucinus
ENSG00000107833NPM310078.652ENSCCAG00000029457-9477.976Cebus_capucinus
ENSG00000107833NPM310099.438ENSCATG00000013755NPM310099.438Cercocebus_atys
ENSG00000107833NPM310099.438ENSCSAG00000005509NPM310099.438Chlorocebus_sabaeus
ENSG00000107833NPM39461.905ENSCPBG00000003817NPM39761.677Chrysemys_picta_bellii
ENSG00000107833NPM310097.753ENSCANG00000020300NPM310097.753Colobus_angolensis_palliatus
ENSG00000107833NPM310082.584ENSCGRG00001013345Npm39480.357Cricetulus_griseus_chok1gshd
ENSG00000107833NPM37879.856ENSCGRG00000015351Npm38576.596Cricetulus_griseus_crigri
ENSG00000107833NPM37946.622ENSCSEG00000007944npm39246.154Cynoglossus_semilaevis
ENSG00000107833NPM36449.573ENSCVAG00000003305npm36751.351Cyprinodon_variegatus
ENSG00000107833NPM36153.704ENSDARG00000103594npm36653.704Danio_rerio
ENSG00000107833NPM310088.202ENSDORG00000003491Npm39486.905Dipodomys_ordii
ENSG00000107833NPM39486.228ENSETEG00000006307NPM39486.228Echinops_telfairi
ENSG00000107833NPM39492.857ENSEASG00005008834NPM310091.011Equus_asinus_asinus
ENSG00000107833NPM39492.857ENSECAG00000007524NPM310091.011Equus_caballus
ENSG00000107833NPM36353.571ENSELUG00000021730npm38347.518Esox_lucius
ENSG00000107833NPM310091.011ENSFCAG00000007178NPM310091.011Felis_catus
ENSG00000107833NPM36566.087ENSFALG00000008586NPM39160.403Ficedula_albicollis
ENSG00000107833NPM36286.486ENSFDAG00000016537NPM310083.784Fukomys_damarensis
ENSG00000107833NPM36151.852ENSFHEG00000003983npm36951.852Fundulus_heteroclitus
ENSG00000107833NPM37947.518ENSGMOG00000004317npm39446.667Gadus_morhua
ENSG00000107833NPM37864.029ENSGALG00000032329NPM39363.309Gallus_gallus
ENSG00000107833NPM36053.271ENSGAFG00000009135npm39448.684Gambusia_affinis
ENSG00000107833NPM36054.717ENSGACG00000007294npm36254.717Gasterosteus_aculeatus
ENSG00000107833NPM37869.565ENSGAGG00000004081NPM38863.750Gopherus_agassizii
ENSG00000107833NPM310099.438ENSGGOG00000027500NPM310099.438Gorilla_gorilla
ENSG00000107833NPM36152.778ENSHBUG00000023704npm36852.778Haplochromis_burtoni
ENSG00000107833NPM39585.207ENSHGLG00000019118NPM310082.022Heterocephalus_glaber_female
ENSG00000107833NPM37885.507ENSHGLG00100010926NPM310082.609Heterocephalus_glaber_male
ENSG00000107833NPM36148.624ENSHCOG00000019322npm38845.270Hippocampus_comes
ENSG00000107833NPM37951.064ENSIPUG00000008204npm38748.936Ictalurus_punctatus
ENSG00000107833NPM39989.831ENSSTOG00000022621NPM39489.820Ictidomys_tridecemlineatus
ENSG00000107833NPM310091.011ENSJJAG00000018907Npm39488.690Jaculus_jaculus
ENSG00000107833NPM36154.630ENSKMAG00000020800npm37547.368Kryptolebias_marmoratus
ENSG00000107833NPM37947.518ENSLBEG00000015651npm38747.518Labrus_bergylta
ENSG00000107833NPM39347.093ENSLOCG00000000705-9646.951Lepisosteus_oculatus
ENSG00000107833NPM39492.857ENSLAFG00000023022NPM39591.667Loxodonta_africana
ENSG00000107833NPM310099.438ENSMFAG00000041878NPM310099.438Macaca_fascicularis
ENSG00000107833NPM310098.876ENSMMUG00000015774NPM310098.876Macaca_mulatta
ENSG00000107833NPM310099.438ENSMNEG00000039999NPM310099.438Macaca_nemestrina
ENSG00000107833NPM310099.438ENSMLEG00000038129NPM310099.438Mandrillus_leucophaeus
ENSG00000107833NPM38148.630ENSMAMG00000002698npm39048.630Mastacembelus_armatus
ENSG00000107833NPM36352.679ENSMZEG00005003091npm36753.704Maylandia_zebra
ENSG00000107833NPM39483.929ENSMAUG00000015218Npm39482.143Mesocricetus_auratus
ENSG00000107833NPM39494.048ENSMICG00000044119NPM39491.667Microcebus_murinus
ENSG00000107833NPM39484.431ENSMOCG00000013601Npm39984.181Microtus_ochrogaster
ENSG00000107833NPM37947.518ENSMMOG00000010681npm38747.518Mola_mola
ENSG00000107833NPM39869.101ENSMODG00000011689NPM39470.000Monodelphis_domestica
ENSG00000107833NPM36647.899ENSMALG00000016787npm39146.104Monopterus_albus
ENSG00000107833NPM39483.929MGP_CAROLIEiJ_G0023020Npm310082.022Mus_caroli
ENSG00000107833NPM39485.119ENSMUSG00000056209Npm310082.584Mus_musculus
ENSG00000107833NPM310084.831MGP_PahariEiJ_G0014510Npm39483.333Mus_pahari
ENSG00000107833NPM310085.393MGP_SPRETEiJ_G0023941Npm39482.143Mus_spretus
ENSG00000107833NPM39492.857ENSMPUG00000016894NPM39491.071Mustela_putorius_furo
ENSG00000107833NPM39787.861ENSMLUG00000004961NPM39289.634Myotis_lucifugus
ENSG00000107833NPM39486.826ENSNGAG00000022833-9485.030Nannospalax_galili
ENSG00000107833NPM39977.966ENSNGAG00000000155-9376.647Nannospalax_galili
ENSG00000107833NPM310099.438ENSNLEG00000029281-10099.438Nomascus_leucogenys
ENSG00000107833NPM310096.629ENSNLEG00000018637-10096.629Nomascus_leucogenys
ENSG00000107833NPM37778.102ENSMEUG00000003465-9380.620Notamacropus_eugenii
ENSG00000107833NPM35672.727ENSMEUG00000002619-10072.727Notamacropus_eugenii
ENSG00000107833NPM35669.697ENSMEUG00000004931-10069.697Notamacropus_eugenii
ENSG00000107833NPM39389.157ENSOPRG00000009229NPM39386.747Ochotona_princeps
ENSG00000107833NPM39784.971ENSODEG00000006704NPM39681.548Octodon_degus
ENSG00000107833NPM36447.458ENSONIG00000009513npm36752.727Oreochromis_niloticus
ENSG00000107833NPM39492.814ENSOCUG00000016819NPM39491.018Oryctolagus_cuniculus
ENSG00000107833NPM36152.778ENSORLG00000008492npm37553.774Oryzias_latipes
ENSG00000107833NPM36152.778ENSORLG00020002450npm37053.774Oryzias_latipes_hni
ENSG00000107833NPM37951.773ENSORLG00015006856npm36852.778Oryzias_latipes_hsok
ENSG00000107833NPM36549.138ENSOMEG00000002666npm37249.138Oryzias_melastigma
ENSG00000107833NPM310091.573ENSOGAG00000010001NPM39489.286Otolemur_garnettii
ENSG00000107833NPM39989.831ENSOARG00000016916NPM39488.623Ovis_aries
ENSG00000107833NPM3100100.000ENSPPAG00000040517NPM3100100.000Pan_paniscus
ENSG00000107833NPM39492.262ENSPPRG00000012611-10090.449Panthera_pardus
ENSG00000107833NPM39491.071ENSPTIG00000005390NPM310091.011Panthera_tigris_altaica
ENSG00000107833NPM3100100.000ENSPTRG00000002875NPM3100100.000Pan_troglodytes
ENSG00000107833NPM310099.438ENSPANG00000021046NPM310099.438Papio_anubis
ENSG00000107833NPM37940.714ENSPKIG00000007609npm35743.396Paramormyrops_kingsleyae
ENSG00000107833NPM36056.075ENSPMGG00000020204npm39247.020Periophthalmus_magnuspinnatus
ENSG00000107833NPM39486.905ENSPEMG00000007731Npm39485.119Peromyscus_maniculatus_bairdii
ENSG00000107833NPM36054.206ENSPFOG00000014692npm36654.206Poecilia_formosa
ENSG00000107833NPM36054.206ENSPLAG00000009956npm36654.206Poecilia_latipinna
ENSG00000107833NPM35754.455ENSPMEG00000011795npm39251.449Poecilia_mexicana
ENSG00000107833NPM36054.206ENSPREG00000020765npm38948.966Poecilia_reticulata
ENSG00000107833NPM310098.333ENSPPYG00000002589NPM38798.333Pongo_abelii
ENSG00000107833NPM310093.820ENSPCOG00000014704NPM39491.667Propithecus_coquereli
ENSG00000107833NPM39493.452ENSPVAG00000004038NPM39491.667Pteropus_vampyrus
ENSG00000107833NPM37952.482ENSPNYG00000009300npm36752.778Pundamilia_nyererei
ENSG00000107833NPM36254.955ENSPNAG00000014779npm37154.955Pygocentrus_nattereri
ENSG00000107833NPM310082.584ENSRNOG00000017622Npm39480.952Rattus_norvegicus
ENSG00000107833NPM39879.310ENSRBIG00000042048-9090.278Rhinopithecus_bieti
ENSG00000107833NPM310097.753ENSRBIG00000039086-10097.753Rhinopithecus_bieti
ENSG00000107833NPM310097.753ENSRROG00000029912NPM310097.753Rhinopithecus_roxellana
ENSG00000107833NPM39696.471ENSSBOG00000027661NPM310096.471Saimiri_boliviensis_boliviensis
ENSG00000107833NPM39264.072ENSSHAG00000008567NPM39463.529Sarcophilus_harrisii
ENSG00000107833NPM36050.943ENSSFOG00015013651npm36750.467Scleropages_formosus
ENSG00000107833NPM37948.227ENSSMAG00000003907npm38748.227Scophthalmus_maximus
ENSG00000107833NPM37951.064ENSSDUG00000022843npm38751.064Seriola_dumerili
ENSG00000107833NPM37951.064ENSSLDG00000002811npm38751.064Seriola_lalandi_dorsalis
ENSG00000107833NPM38663.462ENSSPUG00000011875NPM39660.897Sphenodon_punctatus
ENSG00000107833NPM38349.660ENSSPAG00000002553npm39149.660Stegastes_partitus
ENSG00000107833NPM39990.395ENSSSCG00000010568NPM39488.623Sus_scrofa
ENSG00000107833NPM36268.468ENSTGUG00000009948NPM38369.091Taeniopygia_guttata
ENSG00000107833NPM38249.315ENSTRUG00000011661npm39049.315Takifugu_rubripes
ENSG00000107833NPM36651.282ENSTNIG00000016518npm36750.862Tetraodon_nigroviridis
ENSG00000107833NPM310095.506ENSUAMG00000024072NPM37395.506Ursus_americanus
ENSG00000107833NPM310095.506ENSUMAG00000023016NPM37395.506Ursus_maritimus
ENSG00000107833NPM39494.643ENSVPAG00000003120NPM310091.573Vicugna_pacos
ENSG00000107833NPM39494.611ENSVVUG00000000945NPM38792.090Vulpes_vulpes
ENSG00000107833NPM38146.341ENSXETG00000014472npm36558.929Xenopus_tropicalis
ENSG00000107833NPM36352.679ENSXCOG00000012121npm38851.701Xiphophorus_couchianus
ENSG00000107833NPM36352.679ENSXMAG00000013473npm38851.701Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003682chromatin binding21873635.IBAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding22190034.25416956.IPIFunction
GO:0005654nucleoplasm21873635.IBAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0006338chromatin remodeling21873635.IBAProcess
GO:0006364rRNA processing-IEAProcess
GO:0009303rRNA transcription-IEAProcess
GO:0015629actin cytoskeleton-IDAComponent
GO:0042393histone binding21873635.IBAFunction
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