EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22532625Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.J Mol Cell Biol2012 JunChoi JWdoi: 10.1093/jmcb/mjs018
22285955Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme.J Biotechnol2012 Mar 31Won YSdoi: 10.1016/j.jbiotec.2012.01.006
22562359Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake.Mol Cells2012 JunChang SHdoi: 10.1007/s10059-012-2269-2
21483803Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.PLoS Genet2011 MarChoi JWdoi: 10.1371/journal.pgen.1001351
27302160Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.Cancer Res2016 Aug 15Oh AYdoi: 10.1158/0008-5472.CAN-15-1025

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr76023316Missense_MutationnovelQ196H0.05
BLCAchr760092835'UTRnovel0.15
BLCAchr76015334Missense_MutationNAL108F0.18
BLCAchr76015290Nonsense_MutationnovelQ94*0.06
BLCAchr76009457Missense_Mutationrs200362634G32C0.1
BLCAchr76023600Missense_MutationnovelC291F0.19
BLCAchr76023601Missense_MutationnovelC291W0.18
BRCAchr76023480Frame_Shift_DelNAA253Pfs*70.4
BRCAchr76015180Missense_MutationNAS57F0.12
CESCchr76015251Missense_MutationNAQ81E0.26
CESCchr76017863Missense_MutationnovelP131L0.25
CESCchr76023415Silentrs764803060N229N0.51
CESCchr76023675Frame_Shift_DelnovelL316Pfs*90.11
COADchr76023580SilentNAV284V0.18
COADchr76018013Missense_MutationnovelY181F0.25
COADchr76017901Nonsense_MutationnovelE144*0.11
COADchr760093335'UTRnovel0.06
COADchr76017836Missense_Mutationrs764368950I122T0.34
COADchr76017932Missense_Mutationrs75895975T154M0.16
COADchr76023307Silentrs761471943P193P0.13
COADchr76017854Missense_Mutationrs747974072P128L0.3
COADchr76017928Missense_Mutationrs764843355H153Y0.16
COADchr76017870SilentnovelL133L0.54
ESCAchr76023336Missense_Mutationrs766467029T203M0.38
GBMchr76015148Splice_RegionnovelE46E0.15
GBMchr76017880Missense_MutationnovelV137L0.05
GBMchr76015307Silentrs538013036T99T0.5
GBMchr76023312Missense_MutationnovelT195R0.05
HNSCchr76017991Missense_MutationnovelK174E0.43
HNSCchr76023669Missense_Mutationrs372238513T314M0.15
LGGchr76015228Missense_Mutationrs150139402V73A0.06
LIHCchr76015259SilentnovelP83P0.32
LUADchr76023619SilentNAA297A0.28
LUADchr760093045'UTRnovel0.3
LUSCchr760093395'UTRnovel0.29
LUSCchr76015217Missense_MutationNAL69F0.21
LUSCchr76023295Splice_Regionnovel0.32
LUSCchr76017938Missense_Mutationrs746796665S156F0.24
LUSCchr76023416Missense_Mutationrs756474990A230T0.29
OVchr76017855SilentNAP128P0.31
READchr76018006Missense_Mutationrs750336358Q179E0.76
SKCMchr760092505'UTRnovel0.24
SKCMchr76023376Missense_MutationNAF216L0.16
SKCMchr76015173Missense_MutationnovelL55F0.7
SKCMchr760092505'UTRnovel0.15
SKCMchr76015208SilentnovelL66L0.4
SKCMchr76015240Missense_MutationNAS77F0.46
SKCMchr760092815'UTRrs5660118470.32
STADchr76023438Missense_MutationnovelV237A0.19
STADchr76023678Missense_MutationNAK317T0.15
STADchr76017971Missense_Mutationrs771380350K167R0.1
STADchr76023610SilentnovelT294T0.15
STADchr76023536Missense_Mutationrs770771902A270T0.33
STADchr76023436Nonsense_Mutationrs779256399W236*0.32
STADchr76023591Missense_MutationNAI288S0.35
STADchr76009385Missense_Mutationrs377537932P8S0.27
STADchr76023519Missense_MutationNAG264V0.3
THYMchr76023336Missense_Mutationrs766467029T203M0.3
UCECchr76015295Silentrs746565414A95A0.2
UCECchr760093125'UTRnovel0.32
UCECchr76017819Silentrs747924744Y116Y0.49
UCECchr76023447Missense_Mutationrs140208111A240V0.41
UCECchr76023466SilentnovelE246E0.22
UCECchr76015204Missense_MutationNAR65H0.2
UCECchr76017837SilentNAI122I0.31
UCECchr76023411Missense_MutationNAV228G0.24
UCECchr76023428Missense_MutationNAD234Y0.25
UCECchr76023498Missense_MutationnovelR257L0.1
UCECchr76017838Missense_MutationnovelV123M0.59
UCECchr76023563Missense_Mutationrs374123170V279M0.39
UCECchr76009385Missense_MutationNAP8T0.73
UCECchr76015337Missense_MutationnovelN109K0.39
UCECchr76015294Missense_Mutationrs368845750A95V0.35
UCECchr76023344Missense_MutationnovelP206S0.34
UCECchr76018041Missense_MutationnovelK190N0.26
UCECchr76023669Missense_Mutationrs372238513T314M0.35
UCECchr76018007Missense_MutationnovelQ179R0.32
UCECchr76023313Silentrs767064905T195T0.36
UCECchr76015195Missense_MutationNAI62S0.42
UCECchr76023356Missense_Mutationrs756425703E210K0.38
UCECchr76023408Missense_MutationnovelA227V0.37
UCECchr76015203Missense_Mutationrs140850823R65C0.43
UCSchr76015307Silentrs538013036T99T0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.56670.24436
LUADAMP0.45740.17291
OVDEL0.40413.8574e-27
SKCMAMP0.50680.00015162
STADAMP0.44220.0078915
TGCTAMP0.720.019484
THCADEL00.27619

Survival Analysis
CancerP-value Q-value
MESO0.006

Kaplan-Meier Survival Analysis

ACC0.002

Kaplan-Meier Survival Analysis

HNSC0.00013

Kaplan-Meier Survival Analysis

SKCM0.0018

Kaplan-Meier Survival Analysis

BRCA0.011

Kaplan-Meier Survival Analysis

ESCA0.025

Kaplan-Meier Survival Analysis

BLCA0.00048

Kaplan-Meier Survival Analysis

CESC0.012

Kaplan-Meier Survival Analysis

KICH0.0086

Kaplan-Meier Survival Analysis

UCEC0.031

Kaplan-Meier Survival Analysis

LUAD0.014

Kaplan-Meier Survival Analysis

UVM0.014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000106305 (Gene tree)
Gene ID
7965
Gene Symbol
AIMP2
Alias
p38|PRO0992|JTV-1|JTV1
Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
14,590 bases
Position
chr7:6,009,245-6,023,834
Accession
20609
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19648294p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.Hum Mol Genet2009 Nov 1Farooq Fdoi: 10.1093/hmg/ddp352
23575223Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics.Hum Mol Genet2013 Aug 1Amirouche Adoi: 10.1093/hmg/ddt165
26494902Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.Hum Mol Genet2016 Jan 1Peladeau Cdoi: 10.1093/hmg/ddv444
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000395236AIMP2-202860-ENSP00000378658251 (aa)-F8W950
ENST00000223029AIMP2-2011225-ENSP00000223029320 (aa)-Q13155
ENST00000415999AIMP2-204777-ENSP0000039251948 (aa)-F8WCL2
ENST00000400479AIMP2-2031107XM_005249847ENSP00000383327242 (aa)XP_005249904A8MU58
Gene Model
Click here to download ENSG00000106305's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000106305rs3409703076014758AReticulocyte fraction of red cells27863252[0.021-0.038] unit decrease0.02982401EFO_0007986
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106305's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding16189514.18695251.19060904.21044950.21285945.21516116.21536907.21900206.21988832.22190034.23159739.24212136.24312579.25416956.26496610.26871637.27107012.29997244.IPIFunction
GO:0005634nucleus-IEAComponent
GO:0005829cytosol19289464.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006418tRNA aminoacylation for protein translation-TASProcess
GO:0006915apoptotic process-IEAProcess
GO:0008285negative regulation of cell proliferation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0017101aminoacyl-tRNA synthetase multienzyme complex19131329.IDAComponent
GO:0031398positive regulation of protein ubiquitination-IEAProcess
GO:0060090molecular adaptor activity-IEAFunction
GO:0060510type II pneumocyte differentiation-IEAProcess
GO:0065003protein-containing complex assembly-IEAProcess
GO:1901216positive regulation of neuron death-IEAProcess
GO:1903632positive regulation of aminoacyl-tRNA ligase activity-IEAProcess
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