EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.49
ACC	chr19	48601214	Silent	novel	P444P	0.09
BLCA	chr19	48613159	Missense_Mutation	rs552900271	E72K	0.18	FAM83
BLCA	chr19	48603836	Missense_Mutation	novel	S278R	0.21
BLCA	chr19	48609978	Missense_Mutation	NA	R219Q	0.6
BLCA	chr19	48613159	Missense_Mutation	rs552900271	E72K	0.67	FAM83
BLCA	chr19	48603745	Missense_Mutation	NA	R309C	0.19
BLCA	chr19	48601228	Missense_Mutation	rs781707903	R440C	0.23
BLCA	chr19	48601229	Silent	novel	L439L	0.24
CESC	chr19	48603651	Missense_Mutation	novel	R340L	0.14
CESC	chr19	48613247	Silent	novel	G42G	0.12
CESC	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.32
CESC	chr19	48601134	Frame_Shift_Ins	novel	*R471Pfs78**	0.33
CESC	chr19	48603745	Frame_Shift_Del	novel	*R309Afs46**	0.21
COAD	chr19	48613263	Missense_Mutation	NA	A37V	0.24	FAM83
COAD	chr19	48601288	Frame_Shift_Del	rs778486601	*E420Kfs121**	0.4
COAD	chr19	48612982	Missense_Mutation	novel	Y131N	0.33
COAD	chr19	48603844	Missense_Mutation	rs756248260	A276T	0.34
COAD	chr19	48609979	Missense_Mutation	rs757251950	R219W	0.19
COAD	chr19	48610827	Silent	NA	D162D	0.23
COAD	chr19	48603780	Frame_Shift_Ins	rs773971919	*Q297Pfs33**	0.38
COAD	chr19	48609949	Missense_Mutation	rs543968839	R229W	0.6
COAD	chr19	48601141	Missense_Mutation	novel	A469P	0.35
COAD	chr19	48603801	Missense_Mutation	rs775093735	P290L	0.27
COAD	chr19	48609988	Missense_Mutation	rs748353296	R216C	0.23
COAD	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.48
COAD	chr19	48601315	Missense_Mutation	rs370573825	R411W	0.61
COAD	chr19	48603845	Silent	NA	D275D	0.37
COAD	chr19	48603730	Missense_Mutation	rs577301127	V314M	0.31
COAD	chr19	48609932	Silent	rs201002687	T234T	0.38
COAD	chr19	48613195	Missense_Mutation	rs769111757	S60G	0.42	FAM83
ESCA	chr19	48609988	Missense_Mutation	rs748353296	R216C	0.26
ESCA	chr19	48609928	Missense_Mutation	rs200129085	R236W	0.36
GBM	chr19	48603875	Silent	novel	L265L	0.13
GBM	chr19	48613197	Missense_Mutation	novel	L59P	0.07	FAM83
HNSC	chr19	48603496	Missense_Mutation	rs267605566	E392K	0.3
HNSC	chr19	48601063	3'UTR	rs200607434		0.19
HNSC	chr19	48601206	Missense_Mutation	novel	R447T	0.27
LGG	chr19	48601199	Silent	rs374545212	F449F	0.39
LIHC	chr19	48601355	Missense_Mutation	novel	W397C	0.22
LIHC	chr19	48601356	Missense_Mutation	novel	W397L	0.22
LUAD	chr19	48613244	Silent	rs201699578	A43A	0.17
LUSC	chr19	48603844	Missense_Mutation	rs756248260	A276T	0.42
LUSC	chr19	48613068	Missense_Mutation	novel	P102H	0.14
LUSC	chr19	48603517	Missense_Mutation	novel	G385C	0.2
LUSC	chr19	48603797	Silent	novel	L291L	0.21
OV	chr19	48613166	Silent	rs755994276	A69A	0.54
OV	chr19	48601117	Frame_Shift_Ins	rs766131786	*Q477Afs72**	0.09
PRAD	chr19	48603911	Splice_Region	rs762595974	S253S	0.41
PRAD	chr19	48600953	3'UTR	novel		0.38
PRAD	chr19	48609938	Silent	rs763535279	S232S	0.54
READ	chr19	48601315	Missense_Mutation	rs370573825	R411W	0.26
SKCM	chr19	48603797	Silent	rs369917515	L291L	0.41
SKCM	chr19	48613289	Silent	rs369914216	S28S	0.5
SKCM	chr19	48603807	Missense_Mutation	NA	S288F	0.28
SKCM	chr19	48603725	Silent	NA	S315S	1
SKCM	chr19	48601135	Missense_Mutation	rs561108431	R471W	0.47
SKCM	chr19	48603903	Nonsense_Mutation	novel	W256*	0.25
SKCM	chr19	48609903	Missense_Mutation	novel	G244D	0.35
SKCM	chr19	48601151	Silent	rs369505013	P465P	0.52
SKCM	chr19	48609888	Missense_Mutation	NA	S249L	0.8
SKCM	chr19	48601136	Silent	NA	P470P	0.22
SKCM	chr19	48603792	Missense_Mutation	NA	P293L	0.39
SKCM	chr19	48603802	Missense_Mutation	NA	P290S	0.64
SKCM	chr19	48603551	Silent	NA	S373S	0.37
SKCM	chr19	48601201	Missense_Mutation	NA	F449I	0.22
SKCM	chr19	48603544	Missense_Mutation	NA	D376N	0.28
SKCM	chr19	48603784	Missense_Mutation	novel	P296S	0.58
SKCM	chr19	48603785	Silent	novel	P295P	0.58
SKCM	chr19	48613162	Missense_Mutation	NA	A71T	0.46	FAM83
SKCM	chr19	48613331	Silent	rs749886755	S14S	0.4
SKCM	chr19	48613332	Missense_Mutation	rs745322852	S14F	0.38	FAM83
STAD	chr19	48601135	Frame_Shift_Del	rs754029394	*R471Gfs70**	0.29
STAD	chr19	48609991	Missense_Mutation	rs778310926	V215I	0.26
STAD	chr19	48603594	Missense_Mutation	rs773075907	R359H	0.53
STAD	chr19	48613254	Missense_Mutation	NA	S40N	0.29	FAM83
STAD	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.28
STAD	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.41
STAD	chr19	48603822	Missense_Mutation	rs202240553	T283M	0.19
STAD	chr19	48603720	Missense_Mutation	NA	R317H	0.33
STAD	chr19	48610700	Frame_Shift_Del	novel	V205*	0.43
STAD	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.21
STAD	chr19	48603569	Frame_Shift_Ins	rs748927204	*A368Gfs21**	0.29
STAD	chr19	48609997	Missense_Mutation	rs749545424	V213M	0.38
THCA	chr19	48613295	Silent	NA	L26L	0.4
UCEC	chr19	48609932	Silent	rs201002687	T234T	0.32
UCEC	chr19	48601355	Nonsense_Mutation	NA	W397*	0.32
UCEC	chr19	48613104	Missense_Mutation	rs749433968	T90I	0.45	FAM83
UCEC	chr19	48613070	Nonsense_Mutation	novel	W101*	0.27
UCEC	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.41
UCEC	chr19	48601262	Silent	rs376162806	G428G	0.32
UCEC	chr19	48601346	Missense_Mutation	NA	K400N	0.33
UCEC	chr19	48601258	Missense_Mutation	NA	A430T	0.17
UCEC	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.22
UCEC	chr19	48610838	Missense_Mutation	rs774422280	V159M	0.33
UCEC	chr19	48610745	Missense_Mutation	rs773253521	R190C	0.51
UCEC	chr19	48603781	Frame_Shift_Del	NA	*Q297Rfs6**	0.62
UCEC	chr19	48603594	Missense_Mutation	rs773075907	R359H	0.21
UCEC	chr19	48603692	Silent	rs766951316	P326P	0.6
UCEC	chr19	48613128	Missense_Mutation	novel	S82I	0.1	FAM83
UCEC	chr19	48609876	Missense_Mutation	novel	S253I	0.32
UCEC	chr19	48610780	Missense_Mutation	NA	T178M	0.36
UCEC	chr19	48601317	Missense_Mutation	novel	Q410L	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0915	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.2578	1.5526e-05
LUSC	DEL	0.2116	1.1877e-06
OV	DEL	0.4784	2.441e-17
PAAD	DEL	0.087	0.035089
READ	DEL	0.0909	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.2321	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.041	Kaplan-Meier Survival Analysis
MESO	0.0063	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.00038	Kaplan-Meier Survival Analysis
SKCM	0.0011	Kaplan-Meier Survival Analysis
KIRP	0.00032	Kaplan-Meier Survival Analysis
BLCA	0.024	Kaplan-Meier Survival Analysis
CESC	0.013	Kaplan-Meier Survival Analysis
LIHC	0.021	Kaplan-Meier Survival Analysis
CHOL	0.031	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000105523 (Gene tree)
Gene ID: 54854
Gene Symbol: FAM83E
Alias: FLJ20200
Full Name: family with sequence similarity 83 member E
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 14,255 bases
Position: chr19:48,600,600-48,614,854
Accession: 25972
Summary: FAM83E (Family With Sequence Similarity 83 Member E) is a Protein Coding gene. An important paralog of this gene is FAM83G.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263266	FAM83	PF07894.12	7.7e-100	1	1
ENSP00000470271	FAM83	PF07894.12	1.8e-28	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000263266	FAM83E-201	1926	XM_005259019	ENSP00000263266	478 (aa)	XP_005259076	Q2M2I3
ENST00000593772	FAM83E-202	565	-	ENSP00000470271	91 (aa)	-	M0QZ37
ENST00000599126	FAM83E-204	477	-	-	- (aa)	-	-
ENST00000595110	FAM83E-203	590	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105523's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000105523	Myocardial Infarction	1.4500000E-005	-
ENSG00000105523	Hypertension	1.0931092E-005	-
ENSG00000105523	Alzheimer Disease	8E-6	26993346
ENSG00000105523	Neurodegenerative Diseases	8E-6	26993346
ENSG00000105523	Carcinoembryonic Antigen	5E-8	24941225
ENSG00000105523	Carcinoembryonic Antigen	7E-12	24941225

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105523	rs433852	19	48613847	?	Elevated serum carcinoembryonic antigen levels	24941225			EFO_0005760
ENSG00000105523	rs433852	19	48613847	?	Posterior cortical atrophy and Alzheimer's disease	26993346	[NR]	1.6849171	EFO_0000249\|Orphanet_54247
ENSG00000105523	rs71357834	19	48604360	?	Serum alkaline phosphatase levels	29403010	[0.046-0.069] unit increase novel	0.05724	EFO_0004533
ENSG00000105523	rs2617805	19	48609038	T	Blood protein levels	30072576	[0.11-0.24] unit decrease	0.175	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105523's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105523	FAM83E	82	77.333	ENSAMEG00000014894	-	99	80.069	Ailuropoda_melanoleuca
ENSG00000105523	FAM83E	96	62.069	ENSACAG00000016022	FAM83E	100	51.756	Anolis_carolinensis
ENSG00000105523	FAM83E	100	87.734	ENSANAG00000021014	FAM83E	100	87.734	Aotus_nancymaae
ENSG00000105523	FAM83E	99	76.815	ENSBTAG00000046291	FAM83E	99	76.411	Bos_taurus
ENSG00000105523	FAM83E	98	94.382	ENSCJAG00000000384	FAM83E	100	87.318	Callithrix_jacchus
ENSG00000105523	FAM83E	99	83.333	ENSCAFG00000003971	FAM83E	99	77.485	Canis_familiaris
ENSG00000105523	FAM83E	99	83.333	ENSCAFG00020026383	FAM83E	99	77.485	Canis_lupus_dingo
ENSG00000105523	FAM83E	99	82.222	ENSCHIG00000015933	FAM83E	100	74.648	Capra_hircus
ENSG00000105523	FAM83E	99	84.444	ENSTSYG00000025468	FAM83E	100	74.949	Carlito_syrichta
ENSG00000105523	FAM83E	87	88.608	ENSCAPG00000010952	FAM83E	100	67.540	Cavia_aperea
ENSG00000105523	FAM83E	87	88.608	ENSCPOG00000032844	FAM83E	100	69.618	Cavia_porcellus
ENSG00000105523	FAM83E	98	93.258	ENSCCAG00000021138	FAM83E	100	88.358	Cebus_capucinus
ENSG00000105523	FAM83E	100	94.561	ENSCATG00000044898	FAM83E	100	94.561	Cercocebus_atys
ENSG00000105523	FAM83E	87	89.873	ENSCLAG00000010586	FAM83E	100	71.919	Chinchilla_lanigera
ENSG00000105523	FAM83E	100	94.770	ENSCSAG00000002834	FAM83E	100	94.770	Chlorocebus_sabaeus
ENSG00000105523	FAM83E	96	65.517	ENSCPBG00000008317	FAM83E	68	57.986	Chrysemys_picta_bellii
ENSG00000105523	FAM83E	100	94.351	ENSCANG00000027719	FAM83E	100	94.351	Colobus_angolensis_palliatus
ENSG00000105523	FAM83E	97	80.682	ENSCGRG00001016120	Fam83e	99	70.732	Cricetulus_griseus_chok1gshd
ENSG00000105523	FAM83E	97	79.545	ENSCGRG00000002432	Fam83e	99	70.468	Cricetulus_griseus_crigri
ENSG00000105523	FAM83E	96	83.908	ENSDNOG00000040377	FAM83E	96	74.600	Dasypus_novemcinctus
ENSG00000105523	FAM83E	96	79.310	ENSDORG00000010595	Fam83e	99	73.320	Dipodomys_ordii
ENSG00000105523	FAM83E	99	45.055	ENSEBUG00000010414	FAM83E	57	41.837	Eptatretus_burgeri
ENSG00000105523	FAM83E	100	78.182	ENSEASG00005004610	FAM83E	100	77.172	Equus_asinus_asinus
ENSG00000105523	FAM83E	100	77.980	ENSECAG00000020402	FAM83E	100	76.970	Equus_caballus
ENSG00000105523	FAM83E	96	79.310	ENSEEUG00000015833	FAM83E	100	72.653	Erinaceus_europaeus
ENSG00000105523	FAM83E	100	78.689	ENSFCAG00000018559	FAM83E	100	77.869	Felis_catus
ENSG00000105523	FAM83E	100	67.213	ENSFDAG00000000076	FAM83E	100	67.418	Fukomys_damarensis
ENSG00000105523	FAM83E	96	64.368	ENSGAGG00000013984	FAM83E	88	54.009	Gopherus_agassizii
ENSG00000105523	FAM83E	100	98.745	ENSGGOG00000008727	FAM83E	100	98.745	Gorilla_gorilla
ENSG00000105523	FAM83E	100	71.255	ENSHGLG00000005067	FAM83E	100	71.053	Heterocephalus_glaber_female
ENSG00000105523	FAM83E	100	66.398	ENSHGLG00100015660	FAM83E	100	66.197	Heterocephalus_glaber_male
ENSG00000105523	FAM83E	99	85.556	ENSSTOG00000026049	FAM83E	100	79.550	Ictidomys_tridecemlineatus
ENSG00000105523	FAM83E	99	77.778	ENSJJAG00000018549	Fam83e	99	73.663	Jaculus_jaculus
ENSG00000105523	FAM83E	89	59.259	ENSLACG00000008573	FAM83E	94	45.000	Latimeria_chalumnae
ENSG00000105523	FAM83E	66	72.222	ENSLAFG00000029646	FAM83E	94	70.988	Loxodonta_africana
ENSG00000105523	FAM83E	100	94.770	ENSMFAG00000027835	FAM83E	100	94.770	Macaca_fascicularis
ENSG00000105523	FAM83E	100	93.515	ENSMMUG00000022156	FAM83E	100	93.515	Macaca_mulatta
ENSG00000105523	FAM83E	100	90.586	ENSMNEG00000033849	FAM83E	100	88.912	Macaca_nemestrina
ENSG00000105523	FAM83E	90	93.902	ENSMLEG00000031128	-	99	94.444	Mandrillus_leucophaeus
ENSG00000105523	FAM83E	99	80.000	ENSMAUG00000010116	Fam83e	98	71.310	Mesocricetus_auratus
ENSG00000105523	FAM83E	99	86.667	ENSMICG00000043555	FAM83E	100	63.730	Microcebus_murinus
ENSG00000105523	FAM83E	97	82.955	ENSMOCG00000010689	Fam83e	99	71.690	Microtus_ochrogaster
ENSG00000105523	FAM83E	97	58.947	ENSMODG00000014096	-	99	60.377	Monodelphis_domestica
ENSG00000105523	FAM83E	97	79.545	MGP_CAROLIEiJ_G0029741	Fam83e	99	70.287	Mus_caroli
ENSG00000105523	FAM83E	97	80.682	ENSMUSG00000054161	Fam83e	99	70.287	Mus_musculus
ENSG00000105523	FAM83E	97	79.545	MGP_PahariEiJ_G0012966	Fam83e	99	69.325	Mus_pahari
ENSG00000105523	FAM83E	97	80.682	MGP_SPRETEiJ_G0030839	Fam83e	99	70.287	Mus_spretus
ENSG00000105523	FAM83E	100	74.747	ENSMPUG00000003926	FAM83E	100	74.545	Mustela_putorius_furo
ENSG00000105523	FAM83E	99	80.000	ENSMLUG00000009261	-	99	82.562	Myotis_lucifugus
ENSG00000105523	FAM83E	96	81.609	ENSNGAG00000018652	Fam83e	99	72.211	Nannospalax_galili
ENSG00000105523	FAM83E	90	96.341	ENSNLEG00000027349	-	75	97.619	Nomascus_leucogenys
ENSG00000105523	FAM83E	89	74.074	ENSMEUG00000000624	FAM83E	97	60.175	Notamacropus_eugenii
ENSG00000105523	FAM83E	90	75.000	ENSOPRG00000007483	-	81	71.687	Ochotona_princeps
ENSG00000105523	FAM83E	85	89.610	ENSODEG00000017511	FAM83E	100	71.515	Octodon_degus
ENSG00000105523	FAM83E	85	66.234	ENSOANG00000012773	-	99	57.436	Ornithorhynchus_anatinus
ENSG00000105523	FAM83E	81	81.081	ENSOCUG00000013907	-	61	77.019	Oryctolagus_cuniculus
ENSG00000105523	FAM83E	100	77.666	ENSOGAG00000003559	FAM83E	100	76.459	Otolemur_garnettii
ENSG00000105523	FAM83E	99	78.889	ENSOARG00000011909	FAM83E	100	71.429	Ovis_aries
ENSG00000105523	FAM83E	100	98.901	ENSPPAG00000042307	-	100	99.206	Pan_paniscus
ENSG00000105523	FAM83E	100	78.279	ENSPPRG00000023653	FAM83E	100	77.459	Panthera_pardus
ENSG00000105523	FAM83E	100	99.582	ENSPTRG00000011243	FAM83E	100	99.582	Pan_troglodytes
ENSG00000105523	FAM83E	100	94.770	ENSPANG00000002014	FAM83E	100	94.770	Papio_anubis
ENSG00000105523	FAM83E	91	85.542	ENSPEMG00000011008	Fam83e	99	71.748	Peromyscus_maniculatus_bairdii
ENSG00000105523	FAM83E	88	68.750	ENSPCIG00000001024	FAM83E	96	56.156	Phascolarctos_cinereus
ENSG00000105523	FAM83E	100	93.617	ENSPPYG00000010204	-	100	97.674	Pongo_abelii
ENSG00000105523	FAM83E	90	73.810	ENSPCAG00000011234	FAM83E	71	75.875	Procavia_capensis
ENSG00000105523	FAM83E	99	88.889	ENSPCOG00000014605	FAM83E	100	81.276	Propithecus_coquereli
ENSG00000105523	FAM83E	89	81.481	ENSPVAG00000009522	FAM83E	100	78.894	Pteropus_vampyrus
ENSG00000105523	FAM83E	97	80.682	ENSRNOG00000021039	Fam83e	99	70.697	Rattus_norvegicus
ENSG00000105523	FAM83E	100	94.770	ENSRBIG00000035409	FAM83E	100	94.770	Rhinopithecus_bieti
ENSG00000105523	FAM83E	100	94.770	ENSRROG00000028721	FAM83E	100	94.770	Rhinopithecus_roxellana
ENSG00000105523	FAM83E	97	94.318	ENSSBOG00000016816	FAM83E	100	86.335	Saimiri_boliviensis_boliviensis
ENSG00000105523	FAM83E	99	78.889	ENSSARG00000010353	-	74	76.923	Sorex_araneus
ENSG00000105523	FAM83E	88	66.250	ENSSPUG00000013904	FAM83E	87	50.469	Sphenodon_punctatus
ENSG00000105523	FAM83E	100	76.200	ENSSSCG00000025975	FAM83E	100	76.600	Sus_scrofa
ENSG00000105523	FAM83E	98	83.146	ENSTBEG00000000955	FAM83E	100	69.289	Tupaia_belangeri
ENSG00000105523	FAM83E	99	85.556	ENSTTRG00000008177	FAM83E	99	78.279	Tursiops_truncatus
ENSG00000105523	FAM83E	100	77.374	ENSUAMG00000010673	FAM83E	100	76.364	Ursus_americanus
ENSG00000105523	FAM83E	89	79.012	ENSUMAG00000000616	FAM83E	100	65.432	Ursus_maritimus
ENSG00000105523	FAM83E	99	82.222	ENSVVUG00000023172	FAM83E	99	77.688	Vulpes_vulpes
ENSG00000105523	FAM83E	85	58.442	ENSXETG00000030110	FAM83E	100	41.769	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0019901	protein kinase binding	24736947.	IPI	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.