EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21252914Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release.Cell Death Differ2011 JunFu Mdoi: 10.1038/cdd.2010.181
14715248Induction of hepatoma cells migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.Biochem Biophys Res Commun2004 Jan 30Yu FL-
17690101Raft-dependent endocytosis of autocrine motility factor is phosphatidylinositol 3-kinase-dependent in breast carcinoma cells.J Biol Chem2007 Oct 5Kojic LD-
11688991Identification of genes differentially induced by hypoxia in pancreatic cancer cells.Biochem Biophys Res Commun2001 Nov 9Yoon DY-
17925402Down-regulation of phosphoglucose isomerase/autocrine motility factor expression sensitizes human fibrosarcoma cells to oxidative stress leading to cellular senescence.J Biol Chem2007 Dec 14Funasaka T-
19531650Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer.Cancer Res2009 Jul 1Funasaka Tdoi: 10.1158/0008-5472.CAN-09-0488
23248119Autocrine motility factor promotes HER2 cleavage and signaling in breast cancer cells.Cancer Res2013 Feb 15Kho DHdoi: 10.1158/0008-5472.CAN-12-2149
19787266Phosphoglucose isomerase enhances colorectal cancer metastasis.Int J Oncol2009 NovTsutsumi S-
15570012Autocrine motility factor signaling enhances pancreatic cancer metastasis.Clin Cancer Res2004 Nov 15Tsutsumi S-
26201353Autocrine motility factor promotes epithelial-mesenchymal transition in endometrial cancer via MAPK signaling pathway.Int J Oncol2015 SepLi Ydoi: 10.3892/ijo.2015.3091
24440856GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.Biochim Biophys Acta2014 JunGallardo-P??rez JCdoi: 10.1016/j.bbamcr.2014.01.013

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1934393755Missense_Mutationrs763375030S298L0.45
BLCAchr1934394054SilentNAA350A0.3
BLCAchr1934399310Missense_MutationnovelD458V0.26
BLCAchr1934394060Silentrs779401223F352F0.45
BLCAchr19343652295'UTRrs7769555370.29
BLCAchr1934377787Missense_Mutationrs148548669R180H0.43
BRCAchr1934399224Missense_MutationNAF429L0.33
BRCAchr1934379560Missense_MutationNAT250A0.14
BRCAchr1934393345Intronnovel0.59
BRCAchr1934393457Intronnovel0.42
BRCAchr1934393553Intronnovel0.64
BRCAchr1934381507Silentrs766877580F264F0.13
BRCAchr1934393810Intronnovel0.24
BRCAchr19344001473'UTRnovel0.47
BRCAchr1934393838IntronNA0.47
CESCchr1934393327Intronnovel0.06
CESCchr1934393328Intronnovel0.06
CESCchr1934399292Missense_Mutationrs199570323A452V0.19
CESCchr1934366807Missense_MutationNAA80S0.22
CESCchr1934368661Missense_MutationnovelE121Q0.34
CESCchr1934368684SilentnovelK128K0.29
CESCchr1934399973Silentrs537943038H538H0.49
CESCchr1934366797Silentrs150838903G76G0.47
CHOLchr19343648775'Flanknovel0.24
COADchr1934368713Intronnovel0.12
COADchr1934396377Frame_Shift_DelNAE382Sfs*200.52
COADchr1934366816Missense_MutationNAR83W0.25
COADchr1934396615Silentrs774225651P409P0.23
COADchr19344000973'UTRnovel0.38
COADchr1934366797Silentrs150838903G76G0.24
COADchr1934399976Silentrs766494581D539D0.25
COADchr1934393304Silentrs371025511H287H0.38
COADchr1934365311Silentrs572523544Q15Q0.35
COADchr1934399293Silentrs34604585A452A0.24
COADchr1934393260Missense_Mutationrs748408705R273C0.42
COADchr1934366369SilentnovelG49G0.36
COADchr1934394054Silentrs780075559A350A0.51
COADchr1934393483Intronnovel0.43
ESCAchr1934399750SilentnovelG502G0.3
ESCAchr19343649735'Flanknovel0.19
GBMchr1934378953Missense_MutationnovelT218S0.08
GBMchr1934377880Missense_MutationnovelK211M0.18
GBMchr1934378955Frame_Shift_DelnovelI219Sfs*350.05
GBMchr1934399976Missense_MutationnovelD539E0.08
GBMchr1934377541Missense_MutationNAK147N0.17
GBMchr1934399274Missense_Mutationrs150033276R446Q0.53
GBMchr1934377757Missense_MutationnovelA170G0.08
GBMchr1934396382Missense_MutationnovelE382Q0.31
GBMchr1934377823Missense_MutationnovelI192T0.32
GBMchr1934399280Missense_MutationnovelE448G0.06
GBMchr1934366393Missense_MutationnovelK57N0.09
GBMchr19344000953'UTRnovel0.4
GBMchr1934377510Missense_MutationNAR137Q0.25
HNSCchr19344000553'UTRnovel0.26
HNSCchr1934393369Intronnovel0.3
HNSCchr1934396333SilentnovelT365T0.35
HNSCchr1934396429Missense_MutationnovelQ397H0.29
HNSCchr1934368583Missense_MutationnovelG95C0.47
HNSCchr1934368592Missense_MutationnovelV98L0.09
HNSCchr1934365356SilentNAF30F0.15
KIRPchr19344000683'UTRnovel0.45
KIRPchr1934396347Missense_Mutationrs747466827R370H0.32
LAMLchr1934393950Frame_Shift_InsnovelV318Rfs*170.11
LGGchr1934365314Nonsense_MutationnovelW16*0.41
LGGchr1934399235Missense_MutationnovelT433I0.3
LIHCchr1934399632Splice_SiteNAX492_splice0.38
LIHCchr1934396637SilentnovelR417R0.3
LUADchr1934377541Missense_MutationNAK147N0.29
LUADchr1934394026Missense_Mutationrs373311425Y341C0.12
LUADchr1934377548Missense_MutationNAT150A0.26
LUADchr1934393970SilentnovelL322L0.31
LUADchr1934368616Missense_MutationNAR106W0.08
LUADchr1934366393Missense_MutationNAK57N0.06
LUADchr1934368657Missense_MutationNAM119I0.14
LUADchr1934393409Intronnovel0.28
LUADchr1934399785Missense_MutationnovelG514V0.27
LUADchr1934368807Intronnovel0.23
LUADchr1934377518Missense_MutationNAD140Y0.19
LUADchr1934377520Silentrs11548997D140D0.18
LUSCchr1934399284SilentnovelL449L0.22
LUSCchr1934393871Intronnovel0.29
LUSCchr1934393774Splice_Regionnovel0.19
LUSCchr1934399278SilentnovelK447K0.11
LUSCchr1934379006Splice_SiteNAX235_splice0.46
LUSCchr1934396304Missense_MutationNAD356N0.18
LUSCchr1934399309Missense_MutationnovelD458Y0.16
LUSCchr1934399619Missense_MutationNAG488R0.18
LUSCchr1934394044Missense_Mutationrs137853583R347H0.12
LUSCchr1934399224SilentNAF429F0.19
LUSCchr1934399245SilentnovelL436L0.42
LUSCchr19344000763'UTRnovel0.41
LUSCchr1934394004Missense_MutationnovelE334Q0.13
LUSCchr1934393760Missense_MutationnovelA300P0.1
OVchr1934393329Intronnovel0.23
OVchr1934393315Splice_Regionnovel0.08
OVchr1934399205Splice_SitenovelX424_splice0.08
OVchr1934378938Missense_MutationnovelF213S0.06
OVchr1934379520Splice_RegionnovelP236P0.09
OVchr1934377839SilentnovelA197A0.16
OVchr1934396338Missense_MutationNAS367C0.44
OVchr1934393995Frame_Shift_DelnovelF331Lfs*710.07
OVchr1934393996Missense_MutationnovelF331Y0.07
PAADchr1934393933Missense_Mutationrs756159470T310M0.2
PAADchr1934394013Missense_MutationnovelA337T0.03
PAADchr1934396398Missense_Mutationrs762765572G387D0.18
PAADchr1934377580Silentrs760767295S160S0.05
PRADchr1934368734Intronnovel0.1
READchr1934366826Missense_Mutationrs370578920N86S0.57
READchr1934399741Silentrs138799755F499F0.38
READchr1934399977Missense_Mutationrs547475819A540T0.26
SARCchr19344001403'UTRnovel0.35
SKCMchr1934393386Intronnovel0.2
SKCMchr1934366349Missense_MutationNAT43A0.26
SKCMchr1934378984Nonsense_MutationnovelF229Gfs*30.07
SKCMchr1934368676SilentNAL126L0.07
SKCMchr19344000903'UTRnovel0.08
SKCMchr19344000913'UTRnovel0.08
SKCMchr1934365356SilentNAF30F0.2
SKCMchr1934399212SilentNAL425L0.45
SKCMchr1934393602Intronnovel0.67
SKCMchr1934396633Silentrs752133252P415P0.22
SKCMchr1934366813Missense_MutationnovelE82K0.12
SKCMchr19344000953'UTRnovel0.47
SKCMchr19344000963'UTRnovel0.48
SKCMchr19344000973'UTRnovel0.49
SKCMchr1934368785Intronnovel0.57
SKCMchr1934396424Missense_MutationNAH396Y0.37
SKCMchr19344000403'UTRrs7602703120.15
SKCMchr1934377579Missense_MutationNAS160F0.25
SKCMchr19344000873'UTRnovel0.08
SKCMchr1934393937SilentnovelP311P0.34
SKCMchr1934393938SilentnovelL312L0.35
SKCMchr1934378990Silentrs765662194L230L0.23
SKCMchr19344001653'UTRnovel0.4
SKCMchr19344001663'UTRnovel0.4
SKCMchr1934393449Intronnovel0.57
SKCMchr1934399981Missense_MutationnovelS541F0.64
SKCMchr1934399966Missense_MutationnovelT536I0.32
STADchr1934396389Missense_MutationnovelG384V0.06
STADchr1934366797Silentrs150838903G76G0.13
STADchr1934393847Intronnovel0.09
STADchr1934377564Missense_MutationNAI155S0.3
STADchr1934399631Missense_Mutationrs773208058A492T0.29
STADchr1934399991Silentrs376737076G544G0.17
STADchr1934396325Missense_MutationNAY363H0.08
STADchr1934368772Intronnovel0.25
STADchr19344001613'UTRnovel0.47
STADchr1934377873Missense_MutationNAA209T0.17
THYMchr1934366404Missense_Mutationrs776925897T61M0.28
UCECchr1934396638Missense_Mutationrs767621544R417Q0.43
UCECchr1934377580Silentrs760767295S160S0.47
UCECchr1934377879Missense_MutationNAK211E0.37
UCECchr1934381516Nonsense_Mutationrs778696675W267*0.06
UCECchr1934399620Missense_MutationnovelG488E0.42
UCECchr1934393439Intronnovel0.08
UCECchr1934393611Intronnovel0.14
UCECchr1934377873Missense_MutationNAA209T0.55
UCECchr1934366844Missense_MutationnovelY92C0.41
UCECchr1934393267Missense_Mutationrs772459350S275L0.46
UCECchr1934368703Splice_SiteNAX134_splice0.29
UCECchr1934399977Missense_Mutationrs547475819A540T0.29
UCECchr1934381467Missense_MutationnovelT251I0.05
UCECchr1934368688Missense_MutationnovelK130E0.51
UCECchr1934393780Intronnovel0.19
UCECchr1934368779Intronnovel0.43
UCECchr1934378997Missense_MutationnovelA233T0.21
UCECchr1934393974Missense_MutationnovelG324C0.33
UCECchr1934377503Missense_Mutationrs200500416R135C0.47
UCECchr1934378998Missense_MutationnovelA233V0.34
UCECchr1934393602Intronnovel0.3
UCECchr1934368687Missense_MutationnovelM129I0.41
UCECchr1934399589Missense_MutationnovelV478M0.41
UCECchr1934393956Missense_Mutationrs750708328V318I0.36
UCECchr1934366369SilentnovelG49G0.38
UCECchr1934393702Intronnovel0.57
UCECchr1934394003SilentnovelC333C0.24
UCECchr1934393493Intronnovel0.31
UCECchr1934379531Missense_Mutationrs765378795A240V0.14
UCECchr1934366811Missense_Mutationrs575607644R81Q0.24
UCECchr1934393475Intronnovel0.32
UCECchr1934368692Missense_MutationNAS131Y0.32
UCECchr1934399735Missense_MutationNAK497N0.3
UCECchr1934393869Intronnovel0.41
UCECchr1934393378Intronnovel0.4
UCECchr1934399571Missense_MutationNAR472C0.08
UCECchr1934366811Missense_Mutationrs575607644R81Q0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL00.18166
READDEL0.02420.23023
STADDEL0.13150.1243
THCADEL0.0040.221
UCSDEL0.05360.19877

Survival Analysis
CancerP-value Q-value
THYM0.018

Kaplan-Meier Survival Analysis

STAD0.048

Kaplan-Meier Survival Analysis

HNSC0.0032

Kaplan-Meier Survival Analysis

SKCM0.00023

Kaplan-Meier Survival Analysis

LUSC0.019

Kaplan-Meier Survival Analysis

ESCA0.021

Kaplan-Meier Survival Analysis

UCEC0.013

Kaplan-Meier Survival Analysis

LIHC0.029

Kaplan-Meier Survival Analysis

LGG0.00017

Kaplan-Meier Survival Analysis

CHOL0.031

Kaplan-Meier Survival Analysis

THCA0.0026

Kaplan-Meier Survival Analysis

LUAD0.00021

Kaplan-Meier Survival Analysis

UVM0.0044

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000105220 (Gene tree)
Gene ID
2821
Gene Symbol
GPI
Alias
AMF|NLK
Full Name
glucose-6-phosphate isomerase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
42,934 bases
Position
chr19:34,359,480-34,402,413
Accession
4458
RBP type
non-canonical RBP
Summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15090512The protease Lon and the RNA-binding protein Hfq reduce silencing of the Escherichia coli bgl operon by H-NS.J Bacteriol2004 MayDole S-
26058146Effect of caffeine on the expression pattern of water-soluble proteins in rice (Oryza sativa) seedlings.Nat Prod Commun2015 MayDeng WW-
15175081Differential gene expression in human brain pericytes induced by amyloid-beta protein.Neuropathol Appl Neurobiol2004 JunRensink AA-
26686630Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.Cell Rep2015 Dec 22Rupaimoole Rdoi: 10.1016/j.celrep.2015.11.047
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000647446GPI-2222020-ENSP00000495129316 (aa)-A0A2R8Y6C7
ENST00000587521GPI-207577-ENSP00000464797116 (aa)-K7EIL4
ENST00000644934GPI-2204194-ENSP00000493517558 (aa)-P06744
ENST00000643067GPI-2193014--- (aa)--
ENST00000589640GPI-211571-ENSP00000467590166 (aa)-K7EPY4
ENST00000586425GPI-2051574-ENSP00000467670447 (aa)-K7EQ48
ENST00000592144GPI-216678-ENSP0000046479810 (aa)-A0A0G2JLI6
ENST00000590375GPI-214529-ENSP00000467221159 (aa)-K7EP41
ENST00000588991GPI-2082036-ENSP00000465858569 (aa)-P06744
ENST00000646312GPI-221479--- (aa)--
ENST00000587384GPI-206829-ENSP00000468298139 (aa)-K7ERK8
ENST00000589985GPI-2121516--- (aa)--
ENST00000586077GPI-2033053--- (aa)--
ENST00000642240GPI-218603-ENSP00000496041145 (aa)-A0A2R8YF08
ENST00000356487GPI-2012040-ENSP00000348877558 (aa)-P06744
ENST00000592277GPI-217615-ENSP00000466191146 (aa)-K7ELR7
ENST00000415930GPI-2024341XM_011526754ENSP00000405573597 (aa)XP_011525056A0A2U3TZU2
ENST00000591204GPI-215559-ENSP00000466851162 (aa)-K7ENA0
ENST00000589504GPI-210536--- (aa)--
ENST00000590362GPI-213378--- (aa)--
ENST00000586392GPI-2041706--- (aa)--
ENST00000589399GPI-209582-ENSP00000468201170 (aa)-K7ERC6
Gene Model
Click here to download ENSG00000105220's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00030Pentose phosphate pathwayKEGG
hsa00500Starch and sucrose metabolismKEGG
hsa00520Amino sugar and nucleotide sugar metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105220's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000105220GPI10094.595ENSMUSG00000036427Gpi110093.939Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001701in utero embryonic development-IEAProcess
GO:0001707mesoderm formation-IEAProcess
GO:0004347glucose-6-phosphate isomerase activity21873635.IBAFunction
GO:0005125cytokine activity-IEAFunction
GO:0005576extracellular region-TASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0005975carbohydrate metabolic process8575767.NASProcess
GO:0006094gluconeogenesis21873635.IBAProcess
GO:0006094gluconeogenesis-TASProcess
GO:0006096glycolytic process21873635.IBAProcess
GO:0006959humoral immune response3020690.TASProcess
GO:0007599hemostasis7435496.TASProcess
GO:0007611learning or memory-IEAProcess
GO:0008083growth factor activity-IEAFunction
GO:0010469regulation of signaling receptor activity-IEAProcess
GO:0010595positive regulation of endothelial cell migration1649192.IDAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016866intramolecular transferase activity21873635.IBAFunction
GO:0019242methylglyoxal biosynthetic process-IEAProcess
GO:0031625ubiquitin protein ligase binding24810856.IPIFunction
GO:0032355response to estradiol-IEAProcess
GO:0032570response to progesterone-IEAProcess
GO:0033574response to testosterone-IEAProcess
GO:0034101erythrocyte homeostasis-IEAProcess
GO:0034774secretory granule lumen-TASComponent
GO:0035902response to immobilization stress-IEAProcess
GO:0035994response to muscle stretch-IEAProcess
GO:0042593glucose homeostasis-IEAProcess
GO:0043005neuron projection-IEAComponent
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEAProcess
GO:0043278response to morphine-IEAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0046185aldehyde catabolic process-IEAProcess
GO:0046686response to cadmium ion-IEAProcess
GO:0048029monosaccharide binding21873635.IBAFunction
GO:0051024positive regulation of immunoglobulin secretion3020690.IDAProcess
GO:0051156glucose 6-phosphate metabolic process21873635.IBAProcess
GO:0060170ciliary membrane-IEAComponent
GO:0061621canonical glycolysis-TASProcess
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:1904813ficolin-1-rich granule lumen-TASComponent
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