EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30696738	Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.	MBio	2019 Jan 29	Xu J	doi: 10.1128/mBio.02687-18.
30532030	Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.	Oncogene	2019 Apr	Wang C	doi: 10.1038/s41388-018-0606-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	12807492	Missense_Mutation	novel	V133L	0.44	RNase_HII
BRCA	chr19	12807143	Intron	novel		0.25
BRCA	chr19	12807233	Missense_Mutation	NA	R76P	0.39	RNase_HII
BRCA	chr19	12813181	Missense_Mutation	NA	E246K	0.18
BRCA	chr19	12807063	Silent	NA	E61E	0.13
BRCA	chr19	12813135	Missense_Mutation	rs79767407	F230L	0.17
BRCA	chr19	12813417	Missense_Mutation	NA	S284F	0.27
BRCA	chr19	12806978	Intron	novel		0.15
CESC	chr19	12813568	3'UTR	novel		0.15
COAD	chr19	12807322	Missense_Mutation	NA	L106F	0.36	RNase_HII
COAD	chr19	12807492	Missense_Mutation	NA	V133M	0.31	RNase_HII
COAD	chr19	12810114	Missense_Mutation	rs757486362	R152Q	0.06
COAD	chr19	12813114	Silent	rs531859310	H223H	0.13
COAD	chr19	12807105	Intron	novel		0.33
GBM	chr19	12807217	Silent	novel	L71L	0.07
GBM	chr19	12813423	Missense_Mutation	rs778842661	R286Q	0.6
GBM	chr19	12807427	Missense_Mutation	novel	Y111S	0.18	RNase_HII
GBM	chr19	12807250	Missense_Mutation	novel	K82E	0.05	RNase_HII
HNSC	chr19	12813440	Missense_Mutation	novel	G292C	0.11
KICH	chr19	12806777	Missense_Mutation	novel	E35V	0.27	RNase_HII
KIRC	chr19	12810356	Missense_Mutation	novel	E197Q	0.29
KIRC	chr19	12806988	Intron	novel		0.35
KIRC	chr19	12807097	Intron	novel		0.32
KIRP	chr19	12810388	Silent	novel	G207G	0.42
LGG	chr19	12810177	Missense_Mutation	rs369355807	P173L	0.23
LUAD	chr19	12807260	Missense_Mutation	novel	D85G	0.08	RNase_HII
LUAD	chr19	12810077	Missense_Mutation	novel	V140M	0.07
LUAD	chr19	12806975	Intron	novel		0.09
LUSC	chr19	12807127	Intron	novel		0.44
LUSC	chr19	12813196	Missense_Mutation	NA	D251N	0.33
LUSC	chr19	12807155	Intron	novel		0.42
MESO	chr19	12806602	5'UTR	novel		0.32
OV	chr19	12813499	3'UTR	novel		0.21
OV	chr19	12806893	Intron	novel		0.06
OV	chr19	12807147	Intron	novel		0.09
OV	chr19	12807270	Silent	novel	F88F	0.14
OV	chr19	12813158	Frame_Shift_Ins	novel	*W238Cfs42**	0.07
OV	chr19	12813540	3'UTR	novel		0.06
PAAD	chr19	12813459	Missense_Mutation	novel	S298I	0.1
PCPG	chr19	12807150	Intron	novel		0.08
PRAD	chr19	12813479	3'UTR	rs756331291		0.26
READ	chr19	12807492	Missense_Mutation	NA	V133M	0.33	RNase_HII
READ	chr19	12807273	Silent	rs765310821	V89V	0.43
READ	chr19	12807418	Splice_Site	NA	X108_splice	0.32
SARC	chr19	12806651	5'UTR	novel		0.09
SKCM	chr19	12813408	Missense_Mutation	novel	P281L	0.48
SKCM	chr19	12813409	Silent	novel	P281P	0.49
SKCM	chr19	12807269	Missense_Mutation	NA	F88C	0.28	RNase_HII
SKCM	chr19	12813497	3'UTR	novel		0.29
SKCM	chr19	12807116	Intron	novel		0.27
SKCM	chr19	12813535	3'UTR	novel		0.32
SKCM	chr19	12813495	3'UTR	novel		0.3
SKCM	chr19	12813417	Missense_Mutation	NA	S284F	0.19
SKCM	chr19	12813370	Silent	novel	I268I	0.3
SKCM	chr19	12813403	Silent	novel	A279A	0.34
SKCM	chr19	12813404	Missense_Mutation	rs375883546	R280C	0.33
SKCM	chr19	12813178	Silent	NA	L245L	0.45
SKCM	chr19	12813430	Silent	novel	F288F	0.24
SKCM	chr19	12810132	Missense_Mutation	NA	P158L	0.67
STAD	chr19	12806827	Intron	novel		0.4
STAD	chr19	12806997	Intron	novel		0.21
STAD	chr19	12807491	Silent	NA	G132G	0.25
STAD	chr19	12807290	Missense_Mutation	rs754727728	V95A	0.09	RNase_HII
STAD	chr19	12807489	Missense_Mutation	NA	G132S	0.4	RNase_HII
STAD	chr19	12807125	Intron	novel		0.41
STAD	chr19	12807430	Missense_Mutation	NA	N112S	0.4	RNase_HII
STAD	chr19	12813360	Missense_Mutation	NA	L265P	0.26
UCEC	chr19	12813423	Missense_Mutation	rs778842661	R286Q	0.36
UCEC	chr19	12813410	Missense_Mutation	rs142642923	R282C	0.16
UCEC	chr19	12813509	3'UTR	novel		0.3
UCEC	chr19	12807280	Missense_Mutation	NA	A92T	0.42	RNase_HII
UCEC	chr19	12813577	3'UTR	novel		0.16
UCEC	chr19	12813187	Nonsense_Mutation	novel	E248*	0.2
UCEC	chr19	12807202	Splice_Region	novel		0.11
UCEC	chr19	12807458	Silent	NA	A121A	0.37
UCEC	chr19	12810147	Missense_Mutation	novel	T163M	0.43
UCEC	chr19	12813114	Silent	rs531859310	H223H	0.36
UCEC	chr19	12807477	Missense_Mutation	NA	A128T	0.19	RNase_HII
UCEC	chr19	12807223	Missense_Mutation	novel	E73K	0.49	RNase_HII
UCEC	chr19	12813515	3'UTR	novel		0.34
UCEC	chr19	12810086	Missense_Mutation	NA	V143I	0.55
UCEC	chr19	12807501	Missense_Mutation	novel	T136A	0.31	RNase_HII
UCEC	chr19	12813545	3'UTR	novel		0.26
UCEC	chr19	12810369	Missense_Mutation	novel	D201G	0.34
UCEC	chr19	12807174	Intron	novel		0.39
UCEC	chr19	12810111	Missense_Mutation	rs369325444	A151V	0.37
UCEC	chr19	12806944	Intron	novel		0.23
UCEC	chr19	12813376	Silent	NA	S270S	0.23
UCEC	chr19	12807261	Silent	rs199572212	D85D	0.44
UVM	chr19	12807497	Silent	rs778120777	N134N	0.63

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1017	0.10492
READ	DEL	0.0848	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
THYM	0.029	Kaplan-Meier Survival Analysis
STAD	0.0027	Kaplan-Meier Survival Analysis
SARC	0.0087	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
SKCM	0.00018	Kaplan-Meier Survival Analysis
PRAD	0.049	Kaplan-Meier Survival Analysis
LUSC	0.0054	Kaplan-Meier Survival Analysis
TGCT	0.049	Kaplan-Meier Survival Analysis
KIRP	0.00073	Kaplan-Meier Survival Analysis
COAD	0.034	Kaplan-Meier Survival Analysis
PAAD	0.032	Kaplan-Meier Survival Analysis
PCPG	0.018	Kaplan-Meier Survival Analysis
CESC	0.0001	Kaplan-Meier Survival Analysis
LAML	0.0011	Kaplan-Meier Survival Analysis
KICH	0.0048	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.042	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0036	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000104889 (Gene tree)
Gene ID: 10535
Gene Symbol: RNASEH2A
Alias: RNASEHI|RNHIA|RNHL|AGS4
Full Name: ribonuclease H2 subunit A
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 13,148 bases
Position: chr19:12,802,054-12,815,201
Accession: 18518
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221486	RNase_HII	PF01351.18	5.7e-50	1	1
ENSP00000495087	RNase_HII	PF01351.18	6e-20	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9631007	Potent and selective inhibition of gene expression by an antisense heptanucleotide.	Nat Biotechnol	1996 Jul	Wagner RW	-
8657573	Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.	Nucleic Acids Res	1996 May 15	Melekhovets YF	-
21341043	Delivery of antisense oligonucleotides to the vascular wall.	Methods Mol Med	1999	Holt CM	doi: 10.1385/1-59259-247-3:401.
7489497	The non-RNase H domain of Saccharomyces cerevisiae RNase H1 binds double-stranded RNA: magnesium modulates the switch between double-stranded RNA binding and RNase H activity.	RNA	1995 May	Cerritelli SM	-
12180924	Stage-specific gene expression during sexual development in Phytophthora infestans.	Mol Microbiol	2002 Aug	Fabritius AL	-
17663799	Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes.	BMC Evol Biol	2007 Jul 31	Kochiwa H	-
25961679	Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynucleotides.	Bioconjug Chem	2015 Jun 17	Wu L	doi: 10.1021/acs.bioconjchem.5b00125
30622178	Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.	Proc Natl Acad Sci U S A	2019 Jan 22	Miroshnichenko SK	doi: 10.1073/pnas.1813376116
23442228	Structural basis for dual roles of Aar2p in U5 snRNP assembly.	Genes Dev	2013 Mar 1	Weber G	doi: 10.1101/gad.213207.113
2544887	Plant retrotransposon from Lilium henryi is related to Ty3 of yeast and the gypsy group of Drosophila.	Proc Natl Acad Sci U S A	1989 Jul	Smyth DR	-
11773622	Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA.	Proc Natl Acad Sci U S A	2002 Jan 8	Bassi GS	-
10753627	Functional analysis of the domain organization of Trypanosoma brucei RNase HI.	Biochem Biophys Res Commun	2000 Apr 13	Kobil JH	-
16895922	The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria.	Bioinformatics	2006 Nov 1	Makarova KS	-
17608717	Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium.	FEBS J	2007 Jul	Tadokoro T	doi: 10.1111/j.1742-4658.2007.05903.x
17332757	Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing.	EMBO J	2007 Mar 21	Zheng X	-
17150635	X-ray analyses of hybrid duplexes between antisense oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine and their target RNAs.	Nucleic Acids Symp Ser (Oxf)	2005	Juan EC	-
28955911	SOX2 suppresses the mobility of urothelial carcinoma by promoting the expression of S100A14.	Biochem Biophys Rep	2016 Jun 25	Lee MS	doi: 10.1016/j.bbrep.2016.06.016
30696738	Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.	MBio	2019 Jan 29	Xu J	doi: 10.1128/mBio.02687-18.
7479034	The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids.	Nucleic Acids Res	1995 Oct 11	DeStefano JJ	-
7694232	Binding of nucleic acids to E. coli RNase HI observed by NMR and CD spectroscopy.	Nucleic Acids Res	1993 Oct 11	Oda Y	-
25890199	Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.	BMC Res Notes	2015 Apr 8	Zhang ZZ	doi: 10.1186/s13104-015-1092-1.
25959458	Preparation and characterization of the RNase H domain of Moloney murine leukemia virus reverse transcriptase.	Protein Expr Purif	2015 Sep	Nishimura K	doi: 10.1016/j.pep.2015.04.012
16247966	E. coli RNase HI and the phosphonate-DNA/RNA hybrid: molecular dynamics simulations.	Nucleosides Nucleotides Nucleic Acids	2005	Barvik I Jr	-
8393563	Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.	Nucleic Acids Res	1993 Jul 11	Sanghvi YS	-
10352186	Sequence-specific and conformation-dependent binding of yeast telomerase RNA to single-stranded telomeric DNA.	Nucleic Acids Res	1999 Jun 15	Lue NF	-
7536034	Site and mechanism of antisense inhibition by C-5 propyne oligonucleotides.	Biochemistry	1995 Apr 18	Moulds C	-
3040711	Recognition of 5' and 3' splice site sequences in pre-mRNA studied with a filter binding technique.	J Biol Chem	1987 Aug 25	Tatei K	-
2156079	DNA-hybridization electron microscopy. Localization of five regions of 16 S rRNA on the surface of 30 S ribosomal subunits.	J Mol Biol	1990 Feb 20	Oakes MI	-
1702425	Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities.	J Biol Chem	1991 Jan 5	Furfine ES	-
1668683	Comparison of anti-RNA properties of normal and ellipticine functionalized alpha and beta-oligonucleotides.	Nucleic Acids Symp Ser	1991	Lavignon M	-
1370087	Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.	J Virol	1992 Jan	Pullen KA	-
7632801	Dual-specificity interaction of HIV-1 TAR RNA with Tat peptide-oligonucleotide conjugates.	Bioconjug Chem	1995 May-Jun	Tung CH	-
11876654	Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides.	Biochemistry	2002 Mar 12	Lok CN	-
11254381	Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.	J Mol Biol	2001 Mar 23	Chapados BR	-
16768458	Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA.	Biochemistry	2006 Jun 20	Bohlayer WP	-
19228196	Ribonuclease H: the enzymes in eukaryotes.	FEBS J	2009 Mar	Cerritelli SM	doi: 10.1111/j.1742-4658.2009.06908.x
24880687	Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.	Nucleic Acids Res	2014 Jul	Das K	doi: 10.1093/nar/gku487
1379242	Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.	J Biol Chem	1992 Aug 5	Richter-Cook NJ	-
16912289	Crystal structure of the moloney murine leukemia virus RNase H domain.	J Virol	2006 Sep	Lim D	-
7541196	Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase.	Biochem Biophys Res Commun	1995 Jun 26	Hatta T	-
7518691	Selection of high-affinity RNA ligands to reverse transcriptase: inhibition of cDNA synthesis and RNase H activity.	Biochemistry	1994 Jul 26	Chen H	-
6170324	A method for isolation of oligo(uridylic acid)-containing messenger ribonucleic acid from HeLa cells.	Biochemistry	1981 Sep 15	Wood WM	-
10097067	A cytosine analog that confers enhanced potency to antisense oligonucleotides.	Proc Natl Acad Sci U S A	1999 Mar 30	Flanagan WM	-
9920268	Cellular penetration and antisense activity by a phenoxazine-substituted heptanucleotide.	Nat Biotechnol	1999 Jan	Flanagan WM	-
9933645	Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription.	J Biol Chem	1999 Feb 12	Auxilien S	-
9871579	Optimization of the binding properties of PNA-(5')-DNA chimerae.	Bioorg Med Chem Lett	1998 Mar 17	van der Laan AC	-
1718968	A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active.	J Biol Chem	1991 Nov 5	Evans DB	-
1692317	Identification of a rRNA/chloramphenicol interaction site within the peptidyltransferase center of the 50 S subunit of the Escherichia coli ribosome.	J Biol Chem	1990 May 15	Marconi RT	-
323248	Selective inhibition of phiX RFII compared with fd RFII DNA synthesis in vitro. II. Resolution of discrimination reaction into multiple steps.	J Biol Chem	1977 Apr 25	Vicuna R	-
56461	Dissociation of alpha beta DNA polymerase of avian myeloblastosis virus by dimethyl sulfoxide.	J Virol	1976 Mar	Grandgenett DP	-
9218455	The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.	J Biol Chem	1997 Jul 18	Lima WF	-
9125523	Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA.	Biochemistry	1997 Apr 22	Bruice TW	-
9037376	Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides.	Antiviral Res	1997 Feb	Jairath S	-
8714201	Interaction of yeast elongation factor 3 with polynucleotides, ribosomal RNA and ribosomal subunits.	Indian J Biochem Biophys	1995 Dec	Kovalchuke O	-
8679616	Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.	Biochemistry	1996 Jul 2	Ghosh M	-
7692401	Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase.	Nucleic Acids Res	1993 Sep 11	DeStefano JJ	-
12450061	Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides.	Can J Physiol Pharmacol	2002 Oct	Lacombe J	-
12087157	Antisense properties of tricyclo-DNA.	Nucleic Acids Res	2002 Jul 1	Renneberg D	-
11135550	Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo.	Nat Biotechnol	2001 Jan	Faria M	-
10931921	Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers.	Nucleic Acids Res	2000 Aug 15	Wei X	-
10852702	Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes.	Biochemistry	2000 Jun 20	Noronha AM	-
15683243	Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.	Biochemistry	2005 Feb 8	Shaw-Reid CA	-
15274628	Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.	Biochemistry	2004 Aug 3	Li TK	-
19289131	HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.	J Mol Biol	2009 May 8	Beilhartz GL	doi: 10.1016/j.jmb.2009.03.025
18719385	Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.	Cell Cycle	2008 Aug 15	Pallan PS	-
18197661	Atomic detail investigation of the structure and dynamics of DNA.RNA hybrids: a molecular dynamics study.	J Phys Chem B	2008 Feb 7	Priyakumar UD	doi: 10.1021/jp709827m
18179415	Molecular basis of gene regulation by the THI-box riboswitch.	Mol Microbiol	2008 Feb	Ontiveros-Palacios N	doi: 10.1111/j.1365-2958.2007.06088.x
17989171	Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo.	J Virol	2008 Jan	Oh J	-
17411072	Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.	Biochemistry	2007 May 15	Honcharenko D	-
17165262	The DDE recombinases: diverse roles in acquired and innate immunity.	Ann Allergy Asthma Immunol	2006 Nov	Dreyfus DH	-
17113568	Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).	Biochem Biophys Res Commun	2007 Jan 12	Hang JQ	-
27881299	Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair.	Cell	2016 Nov 3	Ohle C	doi: 10.1016/j.cell.2016.10.001
25664393	Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding.	Cell Cycle	2015	Davis RR	doi: 10.4161/15384101.2014.994996.
23595992	Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybrids.	J Biol Chem	2013 May 31	Chung S	doi: 10.1074/jbc.M113.465641

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590121	RNASEH2A-202	878	-	ENSP00000495087	138 (aa)	-	A0A2R8Y658
ENST00000646769	RNASEH2A-206	714	-	ENSP00000495175	71 (aa)	-	A0A2R8Y606
ENST00000643757	RNASEH2A-205	916	-	-	- (aa)	-	-
ENST00000593017	RNASEH2A-204	1245	-	-	- (aa)	-	-
ENST00000590279	RNASEH2A-203	823	-	-	- (aa)	-	-
ENST00000221486	RNASEH2A-201	2753	XM_006722619	ENSP00000221486	299 (aa)	XP_006722682	O75792

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000104889	Erythrocyte Count	5E-33	28017375
ENSG00000104889	Bronchodilator Agents	2E-7	26503814
ENSG00000104889	Forced Expiratory Volume	2E-7	26503814
ENSG00000104889	Pulmonary Disease, Chronic Obstructive	2E-7	26503814
ENSG00000104889	Erythrocyte Count	2E-12	19862010
ENSG00000104889	Bronchodilator Agents	1E-7	26503814
ENSG00000104889	Forced Expiratory Volume	1E-7	26503814
ENSG00000104889	Pulmonary Disease, Chronic Obstructive	1E-7	26503814

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104889	rs13345720	19	12806872	C	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	26503814	[0.03-0.07] unit decrease	0.05	EFO_0005921\|GO_0097366\|EFO_0000341
ENSG00000104889	rs13345720	19	12806872	C	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	26503814	[1.14-2.52] unit decrease	1.83	EFO_0005921\|GO_0097366\|EFO_0000341
ENSG00000104889	rs4804732	19	12811689	A	Self-reported math ability	30038396	[0.013-0.021] unit decrease	0.0172	EFO_0004875
ENSG00000104889	rs3786712	19	12812911	A	Self-reported math ability (MTAG)	30038396	[0.013-0.02] unit decrease	0.0165	EFO_0004875

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104889's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104889	RNASEH2A	99	65.217	ENSAPOG00000004101	rnaseh2a	100	58.766	Acanthochromis_polyacanthus
ENSG00000104889	RNASEH2A	99	91.429	ENSAMEG00000012323	RNASEH2A	100	85.333	Ailuropoda_melanoleuca
ENSG00000104889	RNASEH2A	99	63.768	ENSACIG00000002658	rnaseh2a	100	65.098	Amphilophus_citrinellus
ENSG00000104889	RNASEH2A	99	63.768	ENSAOCG00000009217	rnaseh2a	100	58.117	Amphiprion_ocellaris
ENSG00000104889	RNASEH2A	99	63.768	ENSAPEG00000022937	rnaseh2a	100	58.117	Amphiprion_percula
ENSG00000104889	RNASEH2A	99	65.217	ENSATEG00000000908	rnaseh2a	100	59.091	Anabas_testudineus
ENSG00000104889	RNASEH2A	99	67.391	ENSACAG00000003338	RNASEH2A	100	64.452	Anolis_carolinensis
ENSG00000104889	RNASEH2A	100	72.697	ENSANAG00000037932	RNASEH2A	100	72.697	Aotus_nancymaae
ENSG00000104889	RNASEH2A	99	64.286	ENSACLG00000009169	rnaseh2a	100	58.117	Astatotilapia_calliptera
ENSG00000104889	RNASEH2A	100	52.475	ENSAMXG00000000436	rnaseh2a	100	52.475	Astyanax_mexicanus
ENSG00000104889	RNASEH2A	99	91.429	ENSBTAG00000009661	RNASEH2A	100	85.667	Bos_taurus
ENSG00000104889	RNASEH2A	90	50.916	WBGene00004383	rnh-2	92	50.916	Caenorhabditis_elegans
ENSG00000104889	RNASEH2A	100	93.000	ENSCJAG00000004873	RNASEH2A	100	93.000	Callithrix_jacchus
ENSG00000104889	RNASEH2A	99	90.580	ENSCAFG00000017159	RNASEH2A	100	86.000	Canis_familiaris
ENSG00000104889	RNASEH2A	100	91.549	ENSCAFG00020005190	RNASEH2A	60	86.000	Canis_lupus_dingo
ENSG00000104889	RNASEH2A	99	91.429	ENSCHIG00000014460	RNASEH2A	100	86.333	Capra_hircus
ENSG00000104889	RNASEH2A	99	94.286	ENSTSYG00000025418	RNASEH2A	100	89.333	Carlito_syrichta
ENSG00000104889	RNASEH2A	64	82.199	ENSCAPG00000003411	RNASEH2A	100	82.199	Cavia_aperea
ENSG00000104889	RNASEH2A	99	91.429	ENSCPOG00000038877	RNASEH2A	100	85.333	Cavia_porcellus
ENSG00000104889	RNASEH2A	99	96.377	ENSCCAG00000030453	RNASEH2A	100	94.667	Cebus_capucinus
ENSG00000104889	RNASEH2A	100	96.000	ENSCATG00000029609	RNASEH2A	100	96.000	Cercocebus_atys
ENSG00000104889	RNASEH2A	99	92.754	ENSCLAG00000014930	RNASEH2A	100	88.667	Chinchilla_lanigera
ENSG00000104889	RNASEH2A	100	95.667	ENSCSAG00000006567	RNASEH2A	100	95.667	Chlorocebus_sabaeus
ENSG00000104889	RNASEH2A	99	68.116	ENSCPBG00000023909	RNASEH2A	100	63.333	Chrysemys_picta_bellii
ENSG00000104889	RNASEH2A	100	51.333	ENSCING00000006190	-	100	51.333	Ciona_intestinalis
ENSG00000104889	RNASEH2A	100	51.333	ENSCSAVG00000010904	-	100	51.333	Ciona_savignyi
ENSG00000104889	RNASEH2A	100	96.000	ENSCANG00000027433	RNASEH2A	100	96.000	Colobus_angolensis_palliatus
ENSG00000104889	RNASEH2A	99	92.029	ENSCGRG00001005021	Rnaseh2a	100	85.099	Cricetulus_griseus_chok1gshd
ENSG00000104889	RNASEH2A	99	92.029	ENSCGRG00000016602	Rnaseh2a	100	85.099	Cricetulus_griseus_crigri
ENSG00000104889	RNASEH2A	99	66.667	ENSCSEG00000009842	rnaseh2a	100	60.131	Cynoglossus_semilaevis
ENSG00000104889	RNASEH2A	96	61.765	ENSCVAG00000021203	rnaseh2a	99	54.698	Cyprinodon_variegatus
ENSG00000104889	RNASEH2A	99	65.942	ENSDARG00000018891	rnaseh2a	99	64.286	Danio_rerio
ENSG00000104889	RNASEH2A	99	92.029	ENSDNOG00000036532	RNASEH2A	100	84.766	Dasypus_novemcinctus
ENSG00000104889	RNASEH2A	99	92.029	ENSDORG00000009008	Rnaseh2a	100	87.333	Dipodomys_ordii
ENSG00000104889	RNASEH2A	95	51.111	FBgn0031252	CG13690	85	48.980	Drosophila_melanogaster
ENSG00000104889	RNASEH2A	99	88.571	ENSETEG00000001956	-	100	74.648	Echinops_telfairi
ENSG00000104889	RNASEH2A	94	57.692	ENSEBUG00000003380	rnaseh2a	92	53.846	Eptatretus_burgeri
ENSG00000104889	RNASEH2A	99	91.429	ENSEASG00005004118	RNASEH2A	94	90.000	Equus_asinus_asinus
ENSG00000104889	RNASEH2A	99	91.429	ENSECAG00000007013	RNASEH2A	100	85.333	Equus_caballus
ENSG00000104889	RNASEH2A	100	88.489	ENSEEUG00000008222	RNASEH2A	100	79.000	Erinaceus_europaeus
ENSG00000104889	RNASEH2A	99	61.594	ENSELUG00000023079	rnaseh2a	100	60.465	Esox_lucius
ENSG00000104889	RNASEH2A	99	90.000	ENSFCAG00000000474	RNASEH2A	100	85.667	Felis_catus
ENSG00000104889	RNASEH2A	99	92.754	ENSFDAG00000003595	RNASEH2A	100	87.000	Fukomys_damarensis
ENSG00000104889	RNASEH2A	99	66.667	ENSFHEG00000007682	rnaseh2a	100	60.656	Fundulus_heteroclitus
ENSG00000104889	RNASEH2A	99	63.768	ENSGMOG00000005650	rnaseh2a	100	57.792	Gadus_morhua
ENSG00000104889	RNASEH2A	99	68.571	ENSGALG00000052002	RNASEH2A	73	59.603	Gallus_gallus
ENSG00000104889	RNASEH2A	99	65.217	ENSGAFG00000009624	rnaseh2a	99	60.133	Gambusia_affinis
ENSG00000104889	RNASEH2A	99	64.493	ENSGACG00000016019	rnaseh2a	100	59.150	Gasterosteus_aculeatus
ENSG00000104889	RNASEH2A	99	68.841	ENSGAGG00000013859	RNASEH2A	100	63.123	Gopherus_agassizii
ENSG00000104889	RNASEH2A	100	98.997	ENSGGOG00000005846	RNASEH2A	100	98.997	Gorilla_gorilla
ENSG00000104889	RNASEH2A	99	64.286	ENSHBUG00000005267	rnaseh2a	96	61.151	Haplochromis_burtoni
ENSG00000104889	RNASEH2A	99	92.029	ENSHGLG00000018801	RNASEH2A	100	86.667	Heterocephalus_glaber_female
ENSG00000104889	RNASEH2A	99	92.029	ENSHGLG00100015773	RNASEH2A	100	87.000	Heterocephalus_glaber_male
ENSG00000104889	RNASEH2A	99	63.043	ENSHCOG00000016593	rnaseh2a	100	59.344	Hippocampus_comes
ENSG00000104889	RNASEH2A	99	68.116	ENSIPUG00000024299	rnaseh2a	100	60.912	Ictalurus_punctatus
ENSG00000104889	RNASEH2A	99	90.000	ENSSTOG00000006224	RNASEH2A	99	89.412	Ictidomys_tridecemlineatus
ENSG00000104889	RNASEH2A	99	92.029	ENSJJAG00000017547	Rnaseh2a	100	87.000	Jaculus_jaculus
ENSG00000104889	RNASEH2A	99	66.667	ENSKMAG00000019829	rnaseh2a	100	59.672	Kryptolebias_marmoratus
ENSG00000104889	RNASEH2A	99	65.217	ENSLBEG00000020494	rnaseh2a	100	58.117	Labrus_bergylta
ENSG00000104889	RNASEH2A	99	72.857	ENSLACG00000007789	RNASEH2A	99	61.176	Latimeria_chalumnae
ENSG00000104889	RNASEH2A	99	65.942	ENSLOCG00000007890	rnaseh2a	99	61.639	Lepisosteus_oculatus
ENSG00000104889	RNASEH2A	99	92.857	ENSLAFG00000015571	RNASEH2A	100	87.333	Loxodonta_africana
ENSG00000104889	RNASEH2A	100	96.000	ENSMFAG00000002011	RNASEH2A	100	96.000	Macaca_fascicularis
ENSG00000104889	RNASEH2A	100	95.667	ENSMMUG00000005690	RNASEH2A	100	95.667	Macaca_mulatta
ENSG00000104889	RNASEH2A	100	95.333	ENSMNEG00000033054	RNASEH2A	100	95.333	Macaca_nemestrina
ENSG00000104889	RNASEH2A	100	95.667	ENSMLEG00000043654	RNASEH2A	100	95.667	Mandrillus_leucophaeus
ENSG00000104889	RNASEH2A	99	64.493	ENSMAMG00000003062	rnaseh2a	97	61.871	Mastacembelus_armatus
ENSG00000104889	RNASEH2A	99	62.857	ENSMZEG00005023857	rnaseh2a	100	57.468	Maylandia_zebra
ENSG00000104889	RNASEH2A	54	80.982	ENSMAUG00000021740	-	100	80.982	Mesocricetus_auratus
ENSG00000104889	RNASEH2A	99	90.000	ENSMAUG00000008286	-	100	88.406	Mesocricetus_auratus
ENSG00000104889	RNASEH2A	99	95.714	ENSMICG00000016430	RNASEH2A	100	86.667	Microcebus_murinus
ENSG00000104889	RNASEH2A	99	91.304	ENSMOCG00000017408	Rnaseh2a	100	84.053	Microtus_ochrogaster
ENSG00000104889	RNASEH2A	99	63.043	ENSMMOG00000008447	rnaseh2a	100	63.922	Mola_mola
ENSG00000104889	RNASEH2A	99	77.143	ENSMODG00000006997	RNASEH2A	100	65.909	Monodelphis_domestica
ENSG00000104889	RNASEH2A	99	65.942	ENSMALG00000021607	rnaseh2a	100	62.353	Monopterus_albus
ENSG00000104889	RNASEH2A	99	94.286	MGP_CAROLIEiJ_G0031319	-	100	98.148	Mus_caroli
ENSG00000104889	RNASEH2A	99	94.286	ENSMUSG00000052926	Rnaseh2a	100	98.148	Mus_musculus
ENSG00000104889	RNASEH2A	99	92.857	MGP_PahariEiJ_G0022924	Rnaseh2a	100	98.148	Mus_pahari
ENSG00000104889	RNASEH2A	99	94.286	MGP_SPRETEiJ_G0032438	Rnaseh2a	100	98.148	Mus_spretus
ENSG00000104889	RNASEH2A	99	89.130	ENSMPUG00000004586	RNASEH2A	100	83.333	Mustela_putorius_furo
ENSG00000104889	RNASEH2A	99	92.029	ENSMLUG00000012723	RNASEH2A	100	87.333	Myotis_lucifugus
ENSG00000104889	RNASEH2A	99	91.429	ENSNGAG00000017988	Rnaseh2a	100	85.714	Nannospalax_galili
ENSG00000104889	RNASEH2A	99	64.286	ENSNBRG00000018731	rnaseh2a	100	58.117	Neolamprologus_brichardi
ENSG00000104889	RNASEH2A	100	98.328	ENSNLEG00000012806	RNASEH2A	100	98.328	Nomascus_leucogenys
ENSG00000104889	RNASEH2A	99	77.372	ENSMEUG00000006001	RNASEH2A	100	75.000	Notamacropus_eugenii
ENSG00000104889	RNASEH2A	100	70.000	ENSOPRG00000004811	RNASEH2A	100	70.000	Ochotona_princeps
ENSG00000104889	RNASEH2A	99	91.304	ENSODEG00000009772	RNASEH2A	100	87.000	Octodon_degus
ENSG00000104889	RNASEH2A	99	63.043	ENSONIG00000018033	rnaseh2a	99	58.117	Oreochromis_niloticus
ENSG00000104889	RNASEH2A	99	62.319	ENSOANG00000009079	RNASEH2A	100	61.184	Ornithorhynchus_anatinus
ENSG00000104889	RNASEH2A	99	65.942	ENSORLG00000004042	rnaseh2a	100	60.458	Oryzias_latipes
ENSG00000104889	RNASEH2A	99	65.942	ENSORLG00020009483	rnaseh2a	100	60.131	Oryzias_latipes_hni
ENSG00000104889	RNASEH2A	99	65.942	ENSORLG00015007548	rnaseh2a	100	60.131	Oryzias_latipes_hsok
ENSG00000104889	RNASEH2A	99	64.493	ENSOMEG00000016454	rnaseh2a	98	64.961	Oryzias_melastigma
ENSG00000104889	RNASEH2A	99	89.130	ENSOGAG00000012214	RNASEH2A	100	84.000	Otolemur_garnettii
ENSG00000104889	RNASEH2A	99	91.429	ENSOARG00000010721	RNASEH2A	100	86.333	Ovis_aries
ENSG00000104889	RNASEH2A	100	98.997	ENSPPAG00000028092	RNASEH2A	100	98.997	Pan_paniscus
ENSG00000104889	RNASEH2A	99	90.000	ENSPPRG00000010585	RNASEH2A	100	86.000	Panthera_pardus
ENSG00000104889	RNASEH2A	99	88.406	ENSPTIG00000013366	RNASEH2A	100	85.333	Panthera_tigris_altaica
ENSG00000104889	RNASEH2A	100	98.328	ENSPTRG00000010542	RNASEH2A	100	98.328	Pan_troglodytes
ENSG00000104889	RNASEH2A	100	96.000	ENSPANG00000034495	RNASEH2A	100	96.000	Papio_anubis
ENSG00000104889	RNASEH2A	99	65.942	ENSPKIG00000009756	rnaseh2a	100	62.295	Paramormyrops_kingsleyae
ENSG00000104889	RNASEH2A	65	61.224	ENSPSIG00000012039	RNASEH2A	100	61.224	Pelodiscus_sinensis
ENSG00000104889	RNASEH2A	97	62.222	ENSPMGG00000023392	rnaseh2a	100	63.922	Periophthalmus_magnuspinnatus
ENSG00000104889	RNASEH2A	99	91.304	ENSPEMG00000018009	Rnaseh2a	100	84.437	Peromyscus_maniculatus_bairdii
ENSG00000104889	RNASEH2A	99	67.143	ENSPMAG00000009060	rnaseh2a	98	60.066	Petromyzon_marinus
ENSG00000104889	RNASEH2A	99	75.714	ENSPCIG00000014119	RNASEH2A	100	66.234	Phascolarctos_cinereus
ENSG00000104889	RNASEH2A	99	65.942	ENSPFOG00000012627	rnaseh2a	100	60.065	Poecilia_formosa
ENSG00000104889	RNASEH2A	99	65.942	ENSPLAG00000015901	rnaseh2a	100	65.882	Poecilia_latipinna
ENSG00000104889	RNASEH2A	67	56.311	ENSPLAG00000018723	-	90	56.311	Poecilia_latipinna
ENSG00000104889	RNASEH2A	67	56.796	ENSPMEG00000009032	-	93	56.796	Poecilia_mexicana
ENSG00000104889	RNASEH2A	99	65.942	ENSPMEG00000000647	rnaseh2a	100	66.275	Poecilia_mexicana
ENSG00000104889	RNASEH2A	99	66.667	ENSPREG00000015015	rnaseh2a	100	60.797	Poecilia_reticulata
ENSG00000104889	RNASEH2A	99	98.540	ENSPPYG00000009608	RNASEH2A	100	97.333	Pongo_abelii
ENSG00000104889	RNASEH2A	99	90.580	ENSPCAG00000015319	RNASEH2A	100	87.333	Procavia_capensis
ENSG00000104889	RNASEH2A	99	94.286	ENSPCOG00000003686	RNASEH2A	100	87.333	Propithecus_coquereli
ENSG00000104889	RNASEH2A	99	92.857	ENSPVAG00000014703	RNASEH2A	100	69.231	Pteropus_vampyrus
ENSG00000104889	RNASEH2A	99	64.286	ENSPNYG00000023986	rnaseh2a	100	53.698	Pundamilia_nyererei
ENSG00000104889	RNASEH2A	99	66.667	ENSPNAG00000021017	rnaseh2a	100	59.804	Pygocentrus_nattereri
ENSG00000104889	RNASEH2A	99	94.286	ENSRNOG00000003504	Rnaseh2a	100	85.099	Rattus_norvegicus
ENSG00000104889	RNASEH2A	100	96.333	ENSRBIG00000023554	RNASEH2A	100	96.333	Rhinopithecus_bieti
ENSG00000104889	RNASEH2A	100	96.333	ENSRROG00000043799	RNASEH2A	100	96.333	Rhinopithecus_roxellana
ENSG00000104889	RNASEH2A	88	36.567	YNL072W	RNH201	84	40.909	Saccharomyces_cerevisiae
ENSG00000104889	RNASEH2A	99	97.101	ENSSBOG00000033164	RNASEH2A	100	95.000	Saimiri_boliviensis_boliviensis
ENSG00000104889	RNASEH2A	99	75.714	ENSSHAG00000015552	RNASEH2A	100	66.452	Sarcophilus_harrisii
ENSG00000104889	RNASEH2A	99	67.391	ENSSFOG00015009692	rnaseh2a	99	62.458	Scleropages_formosus
ENSG00000104889	RNASEH2A	99	66.667	ENSSMAG00000013986	rnaseh2a	99	59.450	Scophthalmus_maximus
ENSG00000104889	RNASEH2A	99	64.493	ENSSDUG00000005280	rnaseh2a	99	59.450	Seriola_dumerili
ENSG00000104889	RNASEH2A	99	64.493	ENSSLDG00000023766	rnaseh2a	100	58.117	Seriola_lalandi_dorsalis
ENSG00000104889	RNASEH2A	99	62.319	ENSSPAG00000012769	rnaseh2a	100	57.468	Stegastes_partitus
ENSG00000104889	RNASEH2A	99	92.857	ENSSSCG00000013737	RNASEH2A	100	87.043	Sus_scrofa
ENSG00000104889	RNASEH2A	99	65.217	ENSTRUG00000000049	rnaseh2a	100	57.742	Takifugu_rubripes
ENSG00000104889	RNASEH2A	99	65.942	ENSTNIG00000004533	rnaseh2a	99	58.766	Tetraodon_nigroviridis
ENSG00000104889	RNASEH2A	99	92.857	ENSTTRG00000003592	RNASEH2A	100	92.488	Tursiops_truncatus
ENSG00000104889	RNASEH2A	100	92.958	ENSUAMG00000019593	RNASEH2A	100	92.958	Ursus_americanus
ENSG00000104889	RNASEH2A	99	92.857	ENSUMAG00000006254	-	73	90.517	Ursus_maritimus
ENSG00000104889	RNASEH2A	99	68.116	ENSXETG00000004762	rnaseh2a	98	62.290	Xenopus_tropicalis
ENSG00000104889	RNASEH2A	100	66.197	ENSXCOG00000013485	rnaseh2a	100	66.197	Xiphophorus_couchianus
ENSG00000104889	RNASEH2A	99	65.942	ENSXMAG00000006953	rnaseh2a	100	60.656	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004523	RNA-DNA hybrid ribonuclease activity	21873635.	IBA	Function
GO:0004523	RNA-DNA hybrid ribonuclease activity	21177858.	IDA	Function
GO:0004540	ribonuclease activity	9789007.	TAS	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	21177858.	TAS	Process
GO:0006298	mismatch repair	21873635.	IBA	Process
GO:0006298	mismatch repair	23603115.	IDA	Process
GO:0006401	RNA catabolic process	21177858.	IDA	Process
GO:0032299	ribonuclease H2 complex	21873635.	IBA	Component
GO:0032299	ribonuclease H2 complex	21177858.	IDA	Component
GO:0043137	DNA replication, removal of RNA primer	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.