EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30696738Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.MBio2019 Jan 29Xu Jdoi: 10.1128/mBio.02687-18.
30532030Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.Oncogene2019 AprWang Cdoi: 10.1038/s41388-018-0606-4

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1912807492Missense_MutationnovelV133L0.44RNase_HII
BRCAchr1912807143Intronnovel0.25
BRCAchr1912807233Missense_MutationNAR76P0.39RNase_HII
BRCAchr1912813181Missense_MutationNAE246K0.18
BRCAchr1912807063SilentNAE61E0.13
BRCAchr1912813135Missense_Mutationrs79767407F230L0.17
BRCAchr1912813417Missense_MutationNAS284F0.27
BRCAchr1912806978Intronnovel0.15
CESCchr19128135683'UTRnovel0.15
COADchr1912807322Missense_MutationNAL106F0.36RNase_HII
COADchr1912807492Missense_MutationNAV133M0.31RNase_HII
COADchr1912810114Missense_Mutationrs757486362R152Q0.06
COADchr1912813114Silentrs531859310H223H0.13
COADchr1912807105Intronnovel0.33
GBMchr1912807217SilentnovelL71L0.07
GBMchr1912813423Missense_Mutationrs778842661R286Q0.6
GBMchr1912807427Missense_MutationnovelY111S0.18RNase_HII
GBMchr1912807250Missense_MutationnovelK82E0.05RNase_HII
HNSCchr1912813440Missense_MutationnovelG292C0.11
KICHchr1912806777Missense_MutationnovelE35V0.27RNase_HII
KIRCchr1912810356Missense_MutationnovelE197Q0.29
KIRCchr1912806988Intronnovel0.35
KIRCchr1912807097Intronnovel0.32
KIRPchr1912810388SilentnovelG207G0.42
LGGchr1912810177Missense_Mutationrs369355807P173L0.23
LUADchr1912807260Missense_MutationnovelD85G0.08RNase_HII
LUADchr1912810077Missense_MutationnovelV140M0.07
LUADchr1912806975Intronnovel0.09
LUSCchr1912807127Intronnovel0.44
LUSCchr1912813196Missense_MutationNAD251N0.33
LUSCchr1912807155Intronnovel0.42
MESOchr19128066025'UTRnovel0.32
OVchr19128134993'UTRnovel0.21
OVchr1912806893Intronnovel0.06
OVchr1912807147Intronnovel0.09
OVchr1912807270SilentnovelF88F0.14
OVchr1912813158Frame_Shift_InsnovelW238Cfs*420.07
OVchr19128135403'UTRnovel0.06
PAADchr1912813459Missense_MutationnovelS298I0.1
PCPGchr1912807150Intronnovel0.08
PRADchr19128134793'UTRrs7563312910.26
READchr1912807492Missense_MutationNAV133M0.33RNase_HII
READchr1912807273Silentrs765310821V89V0.43
READchr1912807418Splice_SiteNAX108_splice0.32
SARCchr19128066515'UTRnovel0.09
SKCMchr1912813408Missense_MutationnovelP281L0.48
SKCMchr1912813409SilentnovelP281P0.49
SKCMchr1912807269Missense_MutationNAF88C0.28RNase_HII
SKCMchr19128134973'UTRnovel0.29
SKCMchr1912807116Intronnovel0.27
SKCMchr19128135353'UTRnovel0.32
SKCMchr19128134953'UTRnovel0.3
SKCMchr1912813417Missense_MutationNAS284F0.19
SKCMchr1912813370SilentnovelI268I0.3
SKCMchr1912813403SilentnovelA279A0.34
SKCMchr1912813404Missense_Mutationrs375883546R280C0.33
SKCMchr1912813178SilentNAL245L0.45
SKCMchr1912813430SilentnovelF288F0.24
SKCMchr1912810132Missense_MutationNAP158L0.67
STADchr1912806827Intronnovel0.4
STADchr1912806997Intronnovel0.21
STADchr1912807491SilentNAG132G0.25
STADchr1912807290Missense_Mutationrs754727728V95A0.09RNase_HII
STADchr1912807489Missense_MutationNAG132S0.4RNase_HII
STADchr1912807125Intronnovel0.41
STADchr1912807430Missense_MutationNAN112S0.4RNase_HII
STADchr1912813360Missense_MutationNAL265P0.26
UCECchr1912813423Missense_Mutationrs778842661R286Q0.36
UCECchr1912813410Missense_Mutationrs142642923R282C0.16
UCECchr19128135093'UTRnovel0.3
UCECchr1912807280Missense_MutationNAA92T0.42RNase_HII
UCECchr19128135773'UTRnovel0.16
UCECchr1912813187Nonsense_MutationnovelE248*0.2
UCECchr1912807202Splice_Regionnovel0.11
UCECchr1912807458SilentNAA121A0.37
UCECchr1912810147Missense_MutationnovelT163M0.43
UCECchr1912813114Silentrs531859310H223H0.36
UCECchr1912807477Missense_MutationNAA128T0.19RNase_HII
UCECchr1912807223Missense_MutationnovelE73K0.49RNase_HII
UCECchr19128135153'UTRnovel0.34
UCECchr1912810086Missense_MutationNAV143I0.55
UCECchr1912807501Missense_MutationnovelT136A0.31RNase_HII
UCECchr19128135453'UTRnovel0.26
UCECchr1912810369Missense_MutationnovelD201G0.34
UCECchr1912807174Intronnovel0.39
UCECchr1912810111Missense_Mutationrs369325444A151V0.37
UCECchr1912806944Intronnovel0.23
UCECchr1912813376SilentNAS270S0.23
UCECchr1912807261Silentrs199572212D85D0.44
UVMchr1912807497Silentrs778120777N134N0.63

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.10170.10492
READDEL0.08480.23023
THCADEL0.0140.10598

Survival Analysis
CancerP-value Q-value
THYM0.029

Kaplan-Meier Survival Analysis

STAD0.0027

Kaplan-Meier Survival Analysis

SARC0.0087

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00014

Kaplan-Meier Survival Analysis

SKCM0.00018

Kaplan-Meier Survival Analysis

PRAD0.049

Kaplan-Meier Survival Analysis

LUSC0.0054

Kaplan-Meier Survival Analysis

TGCT0.049

Kaplan-Meier Survival Analysis

KIRP0.00073

Kaplan-Meier Survival Analysis

COAD0.034

Kaplan-Meier Survival Analysis

PAAD0.032

Kaplan-Meier Survival Analysis

PCPG0.018

Kaplan-Meier Survival Analysis

CESC0.0001

Kaplan-Meier Survival Analysis

LAML0.0011

Kaplan-Meier Survival Analysis

KICH0.0048

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

DLBC0.042

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0036

Kaplan-Meier Survival Analysis

OV0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000104889 (Gene tree)
Gene ID
10535
Gene Symbol
RNASEH2A
Alias
RNASEHI|RNHIA|RNHL|AGS4
Full Name
ribonuclease H2 subunit A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
13,148 bases
Position
chr19:12,802,054-12,815,201
Accession
18518
RBP type
canonical RBP
Summary
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000221486RNase_HIIPF01351.185.7e-5011
ENSP00000495087RNase_HIIPF01351.186e-2011

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9631007Potent and selective inhibition of gene expression by an antisense heptanucleotide.Nat Biotechnol1996 JulWagner RW-
8657573Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.Nucleic Acids Res1996 May 15Melekhovets YF-
21341043Delivery of antisense oligonucleotides to the vascular wall.Methods Mol Med1999Holt CMdoi: 10.1385/1-59259-247-3:401.
7489497The non-RNase H domain of Saccharomyces cerevisiae RNase H1 binds double-stranded RNA: magnesium modulates the switch between double-stranded RNA binding and RNase H activity.RNA1995 MayCerritelli SM-
12180924Stage-specific gene expression during sexual development in Phytophthora infestans.Mol Microbiol2002 AugFabritius AL-
17663799Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes.BMC Evol Biol2007 Jul 31Kochiwa H-
25961679Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynucleotides.Bioconjug Chem2015 Jun 17Wu Ldoi: 10.1021/acs.bioconjchem.5b00125
30622178Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.Proc Natl Acad Sci U S A2019 Jan 22Miroshnichenko SKdoi: 10.1073/pnas.1813376116
23442228Structural basis for dual roles of Aar2p in U5 snRNP assembly.Genes Dev2013 Mar 1Weber Gdoi: 10.1101/gad.213207.113
2544887Plant retrotransposon from Lilium henryi is related to Ty3 of yeast and the gypsy group of Drosophila.Proc Natl Acad Sci U S A1989 JulSmyth DR-
11773622Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA.Proc Natl Acad Sci U S A2002 Jan 8Bassi GS-
10753627Functional analysis of the domain organization of Trypanosoma brucei RNase HI.Biochem Biophys Res Commun2000 Apr 13Kobil JH-
16895922The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria.Bioinformatics2006 Nov 1Makarova KS-
17608717Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium.FEBS J2007 JulTadokoro Tdoi: 10.1111/j.1742-4658.2007.05903.x
17332757Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing.EMBO J2007 Mar 21Zheng X-
17150635X-ray analyses of hybrid duplexes between antisense oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine and their target RNAs.Nucleic Acids Symp Ser (Oxf)2005Juan EC-
28955911SOX2 suppresses the mobility of urothelial carcinoma by promoting the expression of S100A14.Biochem Biophys Rep2016 Jun 25Lee MSdoi: 10.1016/j.bbrep.2016.06.016
30696738Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.MBio2019 Jan 29Xu Jdoi: 10.1128/mBio.02687-18.
7479034The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids.Nucleic Acids Res1995 Oct 11DeStefano JJ-
7694232Binding of nucleic acids to E. coli RNase HI observed by NMR and CD spectroscopy.Nucleic Acids Res1993 Oct 11Oda Y-
25890199Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.BMC Res Notes2015 Apr 8Zhang ZZdoi: 10.1186/s13104-015-1092-1.
25959458Preparation and characterization of the RNase H domain of Moloney murine leukemia virus reverse transcriptase.Protein Expr Purif2015 SepNishimura Kdoi: 10.1016/j.pep.2015.04.012
16247966E. coli RNase HI and the phosphonate-DNA/RNA hybrid: molecular dynamics simulations.Nucleosides Nucleotides Nucleic Acids2005Barvik I Jr-
8393563Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.Nucleic Acids Res1993 Jul 11Sanghvi YS-
10352186Sequence-specific and conformation-dependent binding of yeast telomerase RNA to single-stranded telomeric DNA.Nucleic Acids Res1999 Jun 15Lue NF-
7536034Site and mechanism of antisense inhibition by C-5 propyne oligonucleotides.Biochemistry1995 Apr 18Moulds C-
3040711Recognition of 5' and 3' splice site sequences in pre-mRNA studied with a filter binding technique.J Biol Chem1987 Aug 25Tatei K-
2156079DNA-hybridization electron microscopy. Localization of five regions of 16 S rRNA on the surface of 30 S ribosomal subunits.J Mol Biol1990 Feb 20Oakes MI-
1702425Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities.J Biol Chem1991 Jan 5Furfine ES-
1668683Comparison of anti-RNA properties of normal and ellipticine functionalized alpha and beta-oligonucleotides.Nucleic Acids Symp Ser1991Lavignon M-
1370087Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.J Virol1992 JanPullen KA-
7632801Dual-specificity interaction of HIV-1 TAR RNA with Tat peptide-oligonucleotide conjugates.Bioconjug Chem1995 May-JunTung CH-
11876654Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides.Biochemistry2002 Mar 12Lok CN-
11254381Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.J Mol Biol2001 Mar 23Chapados BR-
16768458Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA.Biochemistry2006 Jun 20Bohlayer WP-
19228196Ribonuclease H: the enzymes in eukaryotes.FEBS J2009 MarCerritelli SMdoi: 10.1111/j.1742-4658.2009.06908.x
24880687Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.Nucleic Acids Res2014 JulDas Kdoi: 10.1093/nar/gku487
1379242Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.J Biol Chem1992 Aug 5Richter-Cook NJ-
16912289Crystal structure of the moloney murine leukemia virus RNase H domain.J Virol2006 SepLim D-
7541196Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase.Biochem Biophys Res Commun1995 Jun 26Hatta T-
7518691Selection of high-affinity RNA ligands to reverse transcriptase: inhibition of cDNA synthesis and RNase H activity.Biochemistry1994 Jul 26Chen H-
6170324A method for isolation of oligo(uridylic acid)-containing messenger ribonucleic acid from HeLa cells.Biochemistry1981 Sep 15Wood WM-
10097067A cytosine analog that confers enhanced potency to antisense oligonucleotides.Proc Natl Acad Sci U S A1999 Mar 30Flanagan WM-
9920268Cellular penetration and antisense activity by a phenoxazine-substituted heptanucleotide.Nat Biotechnol1999 JanFlanagan WM-
9933645Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription.J Biol Chem1999 Feb 12Auxilien S-
9871579Optimization of the binding properties of PNA-(5')-DNA chimerae.Bioorg Med Chem Lett1998 Mar 17van der Laan AC-
1718968A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active.J Biol Chem1991 Nov 5Evans DB-
1692317Identification of a rRNA/chloramphenicol interaction site within the peptidyltransferase center of the 50 S subunit of the Escherichia coli ribosome.J Biol Chem1990 May 15Marconi RT-
323248Selective inhibition of phiX RFII compared with fd RFII DNA synthesis in vitro. II. Resolution of discrimination reaction into multiple steps.J Biol Chem1977 Apr 25Vicuna R-
56461Dissociation of alpha beta DNA polymerase of avian myeloblastosis virus by dimethyl sulfoxide.J Virol1976 MarGrandgenett DP-
9218455The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.J Biol Chem1997 Jul 18Lima WF-
9125523Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA.Biochemistry1997 Apr 22Bruice TW-
9037376Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides.Antiviral Res1997 FebJairath S-
8714201Interaction of yeast elongation factor 3 with polynucleotides, ribosomal RNA and ribosomal subunits.Indian J Biochem Biophys1995 DecKovalchuke O-
8679616Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.Biochemistry1996 Jul 2Ghosh M-
7692401Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase.Nucleic Acids Res1993 Sep 11DeStefano JJ-
12450061Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides.Can J Physiol Pharmacol2002 OctLacombe J-
12087157Antisense properties of tricyclo-DNA.Nucleic Acids Res2002 Jul 1Renneberg D-
11135550Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo.Nat Biotechnol2001 JanFaria M-
10931921Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers.Nucleic Acids Res2000 Aug 15Wei X-
10852702Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes.Biochemistry2000 Jun 20Noronha AM-
15683243Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.Biochemistry2005 Feb 8Shaw-Reid CA-
15274628Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.Biochemistry2004 Aug 3Li TK-
19289131HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.J Mol Biol2009 May 8Beilhartz GLdoi: 10.1016/j.jmb.2009.03.025
18719385Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.Cell Cycle2008 Aug 15Pallan PS-
18197661Atomic detail investigation of the structure and dynamics of DNA.RNA hybrids: a molecular dynamics study.J Phys Chem B2008 Feb 7Priyakumar UDdoi: 10.1021/jp709827m
18179415Molecular basis of gene regulation by the THI-box riboswitch.Mol Microbiol2008 FebOntiveros-Palacios Ndoi: 10.1111/j.1365-2958.2007.06088.x
17989171Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo.J Virol2008 JanOh J-
17411072Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.Biochemistry2007 May 15Honcharenko D-
17165262The DDE recombinases: diverse roles in acquired and innate immunity.Ann Allergy Asthma Immunol2006 NovDreyfus DH-
17113568Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).Biochem Biophys Res Commun2007 Jan 12Hang JQ-
27881299Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair.Cell2016 Nov 3Ohle Cdoi: 10.1016/j.cell.2016.10.001
25664393Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding.Cell Cycle2015Davis RRdoi: 10.4161/15384101.2014.994996.
23595992Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybrids.J Biol Chem2013 May 31Chung Sdoi: 10.1074/jbc.M113.465641
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000590121RNASEH2A-202878-ENSP00000495087138 (aa)-A0A2R8Y658
ENST00000646769RNASEH2A-206714-ENSP0000049517571 (aa)-A0A2R8Y606
ENST00000643757RNASEH2A-205916--- (aa)--
ENST00000593017RNASEH2A-2041245--- (aa)--
ENST00000590279RNASEH2A-203823--- (aa)--
ENST00000221486RNASEH2A-2012753XM_006722619ENSP00000221486299 (aa)XP_006722682O75792
Gene Model
Click here to download ENSG00000104889's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000104889Erythrocyte Count5E-3328017375
ENSG00000104889Bronchodilator Agents2E-726503814
ENSG00000104889Forced Expiratory Volume2E-726503814
ENSG00000104889Pulmonary Disease, Chronic Obstructive2E-726503814
ENSG00000104889Erythrocyte Count2E-1219862010
ENSG00000104889Bronchodilator Agents1E-726503814
ENSG00000104889Forced Expiratory Volume1E-726503814
ENSG00000104889Pulmonary Disease, Chronic Obstructive1E-726503814
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000104889rs133457201912806872CResponse to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)26503814[0.03-0.07] unit decrease0.05EFO_0005921|GO_0097366|EFO_0000341
ENSG00000104889rs133457201912806872CResponse to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)26503814[1.14-2.52] unit decrease1.83EFO_0005921|GO_0097366|EFO_0000341
ENSG00000104889rs48047321912811689ASelf-reported math ability30038396[0.013-0.021] unit decrease0.0172EFO_0004875
ENSG00000104889rs37867121912812911ASelf-reported math ability (MTAG)30038396[0.013-0.02] unit decrease0.0165EFO_0004875
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104889's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000104889RNASEH2A9965.217ENSAPOG00000004101rnaseh2a10058.766Acanthochromis_polyacanthus
ENSG00000104889RNASEH2A9991.429ENSAMEG00000012323RNASEH2A10085.333Ailuropoda_melanoleuca
ENSG00000104889RNASEH2A9963.768ENSACIG00000002658rnaseh2a10065.098Amphilophus_citrinellus
ENSG00000104889RNASEH2A9963.768ENSAOCG00000009217rnaseh2a10058.117Amphiprion_ocellaris
ENSG00000104889RNASEH2A9963.768ENSAPEG00000022937rnaseh2a10058.117Amphiprion_percula
ENSG00000104889RNASEH2A9965.217ENSATEG00000000908rnaseh2a10059.091Anabas_testudineus
ENSG00000104889RNASEH2A9967.391ENSACAG00000003338RNASEH2A10064.452Anolis_carolinensis
ENSG00000104889RNASEH2A10072.697ENSANAG00000037932RNASEH2A10072.697Aotus_nancymaae
ENSG00000104889RNASEH2A9964.286ENSACLG00000009169rnaseh2a10058.117Astatotilapia_calliptera
ENSG00000104889RNASEH2A10052.475ENSAMXG00000000436rnaseh2a10052.475Astyanax_mexicanus
ENSG00000104889RNASEH2A9991.429ENSBTAG00000009661RNASEH2A10085.667Bos_taurus
ENSG00000104889RNASEH2A9050.916WBGene00004383rnh-29250.916Caenorhabditis_elegans
ENSG00000104889RNASEH2A10093.000ENSCJAG00000004873RNASEH2A10093.000Callithrix_jacchus
ENSG00000104889RNASEH2A9990.580ENSCAFG00000017159RNASEH2A10086.000Canis_familiaris
ENSG00000104889RNASEH2A10091.549ENSCAFG00020005190RNASEH2A6086.000Canis_lupus_dingo
ENSG00000104889RNASEH2A9991.429ENSCHIG00000014460RNASEH2A10086.333Capra_hircus
ENSG00000104889RNASEH2A9994.286ENSTSYG00000025418RNASEH2A10089.333Carlito_syrichta
ENSG00000104889RNASEH2A6482.199ENSCAPG00000003411RNASEH2A10082.199Cavia_aperea
ENSG00000104889RNASEH2A9991.429ENSCPOG00000038877RNASEH2A10085.333Cavia_porcellus
ENSG00000104889RNASEH2A9996.377ENSCCAG00000030453RNASEH2A10094.667Cebus_capucinus
ENSG00000104889RNASEH2A10096.000ENSCATG00000029609RNASEH2A10096.000Cercocebus_atys
ENSG00000104889RNASEH2A9992.754ENSCLAG00000014930RNASEH2A10088.667Chinchilla_lanigera
ENSG00000104889RNASEH2A10095.667ENSCSAG00000006567RNASEH2A10095.667Chlorocebus_sabaeus
ENSG00000104889RNASEH2A9968.116ENSCPBG00000023909RNASEH2A10063.333Chrysemys_picta_bellii
ENSG00000104889RNASEH2A10051.333ENSCING00000006190-10051.333Ciona_intestinalis
ENSG00000104889RNASEH2A10051.333ENSCSAVG00000010904-10051.333Ciona_savignyi
ENSG00000104889RNASEH2A10096.000ENSCANG00000027433RNASEH2A10096.000Colobus_angolensis_palliatus
ENSG00000104889RNASEH2A9992.029ENSCGRG00001005021Rnaseh2a10085.099Cricetulus_griseus_chok1gshd
ENSG00000104889RNASEH2A9992.029ENSCGRG00000016602Rnaseh2a10085.099Cricetulus_griseus_crigri
ENSG00000104889RNASEH2A9966.667ENSCSEG00000009842rnaseh2a10060.131Cynoglossus_semilaevis
ENSG00000104889RNASEH2A9661.765ENSCVAG00000021203rnaseh2a9954.698Cyprinodon_variegatus
ENSG00000104889RNASEH2A9965.942ENSDARG00000018891rnaseh2a9964.286Danio_rerio
ENSG00000104889RNASEH2A9992.029ENSDNOG00000036532RNASEH2A10084.766Dasypus_novemcinctus
ENSG00000104889RNASEH2A9992.029ENSDORG00000009008Rnaseh2a10087.333Dipodomys_ordii
ENSG00000104889RNASEH2A9551.111FBgn0031252CG136908548.980Drosophila_melanogaster
ENSG00000104889RNASEH2A9988.571ENSETEG00000001956-10074.648Echinops_telfairi
ENSG00000104889RNASEH2A9457.692ENSEBUG00000003380rnaseh2a9253.846Eptatretus_burgeri
ENSG00000104889RNASEH2A9991.429ENSEASG00005004118RNASEH2A9490.000Equus_asinus_asinus
ENSG00000104889RNASEH2A9991.429ENSECAG00000007013RNASEH2A10085.333Equus_caballus
ENSG00000104889RNASEH2A10088.489ENSEEUG00000008222RNASEH2A10079.000Erinaceus_europaeus
ENSG00000104889RNASEH2A9961.594ENSELUG00000023079rnaseh2a10060.465Esox_lucius
ENSG00000104889RNASEH2A9990.000ENSFCAG00000000474RNASEH2A10085.667Felis_catus
ENSG00000104889RNASEH2A9992.754ENSFDAG00000003595RNASEH2A10087.000Fukomys_damarensis
ENSG00000104889RNASEH2A9966.667ENSFHEG00000007682rnaseh2a10060.656Fundulus_heteroclitus
ENSG00000104889RNASEH2A9963.768ENSGMOG00000005650rnaseh2a10057.792Gadus_morhua
ENSG00000104889RNASEH2A9968.571ENSGALG00000052002RNASEH2A7359.603Gallus_gallus
ENSG00000104889RNASEH2A9965.217ENSGAFG00000009624rnaseh2a9960.133Gambusia_affinis
ENSG00000104889RNASEH2A9964.493ENSGACG00000016019rnaseh2a10059.150Gasterosteus_aculeatus
ENSG00000104889RNASEH2A9968.841ENSGAGG00000013859RNASEH2A10063.123Gopherus_agassizii
ENSG00000104889RNASEH2A10098.997ENSGGOG00000005846RNASEH2A10098.997Gorilla_gorilla
ENSG00000104889RNASEH2A9964.286ENSHBUG00000005267rnaseh2a9661.151Haplochromis_burtoni
ENSG00000104889RNASEH2A9992.029ENSHGLG00000018801RNASEH2A10086.667Heterocephalus_glaber_female
ENSG00000104889RNASEH2A9992.029ENSHGLG00100015773RNASEH2A10087.000Heterocephalus_glaber_male
ENSG00000104889RNASEH2A9963.043ENSHCOG00000016593rnaseh2a10059.344Hippocampus_comes
ENSG00000104889RNASEH2A9968.116ENSIPUG00000024299rnaseh2a10060.912Ictalurus_punctatus
ENSG00000104889RNASEH2A9990.000ENSSTOG00000006224RNASEH2A9989.412Ictidomys_tridecemlineatus
ENSG00000104889RNASEH2A9992.029ENSJJAG00000017547Rnaseh2a10087.000Jaculus_jaculus
ENSG00000104889RNASEH2A9966.667ENSKMAG00000019829rnaseh2a10059.672Kryptolebias_marmoratus
ENSG00000104889RNASEH2A9965.217ENSLBEG00000020494rnaseh2a10058.117Labrus_bergylta
ENSG00000104889RNASEH2A9972.857ENSLACG00000007789RNASEH2A9961.176Latimeria_chalumnae
ENSG00000104889RNASEH2A9965.942ENSLOCG00000007890rnaseh2a9961.639Lepisosteus_oculatus
ENSG00000104889RNASEH2A9992.857ENSLAFG00000015571RNASEH2A10087.333Loxodonta_africana
ENSG00000104889RNASEH2A10096.000ENSMFAG00000002011RNASEH2A10096.000Macaca_fascicularis
ENSG00000104889RNASEH2A10095.667ENSMMUG00000005690RNASEH2A10095.667Macaca_mulatta
ENSG00000104889RNASEH2A10095.333ENSMNEG00000033054RNASEH2A10095.333Macaca_nemestrina
ENSG00000104889RNASEH2A10095.667ENSMLEG00000043654RNASEH2A10095.667Mandrillus_leucophaeus
ENSG00000104889RNASEH2A9964.493ENSMAMG00000003062rnaseh2a9761.871Mastacembelus_armatus
ENSG00000104889RNASEH2A9962.857ENSMZEG00005023857rnaseh2a10057.468Maylandia_zebra
ENSG00000104889RNASEH2A5480.982ENSMAUG00000021740-10080.982Mesocricetus_auratus
ENSG00000104889RNASEH2A9990.000ENSMAUG00000008286-10088.406Mesocricetus_auratus
ENSG00000104889RNASEH2A9995.714ENSMICG00000016430RNASEH2A10086.667Microcebus_murinus
ENSG00000104889RNASEH2A9991.304ENSMOCG00000017408Rnaseh2a10084.053Microtus_ochrogaster
ENSG00000104889RNASEH2A9963.043ENSMMOG00000008447rnaseh2a10063.922Mola_mola
ENSG00000104889RNASEH2A9977.143ENSMODG00000006997RNASEH2A10065.909Monodelphis_domestica
ENSG00000104889RNASEH2A9965.942ENSMALG00000021607rnaseh2a10062.353Monopterus_albus
ENSG00000104889RNASEH2A9994.286MGP_CAROLIEiJ_G0031319-10098.148Mus_caroli
ENSG00000104889RNASEH2A9994.286ENSMUSG00000052926Rnaseh2a10098.148Mus_musculus
ENSG00000104889RNASEH2A9992.857MGP_PahariEiJ_G0022924Rnaseh2a10098.148Mus_pahari
ENSG00000104889RNASEH2A9994.286MGP_SPRETEiJ_G0032438Rnaseh2a10098.148Mus_spretus
ENSG00000104889RNASEH2A9989.130ENSMPUG00000004586RNASEH2A10083.333Mustela_putorius_furo
ENSG00000104889RNASEH2A9992.029ENSMLUG00000012723RNASEH2A10087.333Myotis_lucifugus
ENSG00000104889RNASEH2A9991.429ENSNGAG00000017988Rnaseh2a10085.714Nannospalax_galili
ENSG00000104889RNASEH2A9964.286ENSNBRG00000018731rnaseh2a10058.117Neolamprologus_brichardi
ENSG00000104889RNASEH2A10098.328ENSNLEG00000012806RNASEH2A10098.328Nomascus_leucogenys
ENSG00000104889RNASEH2A9977.372ENSMEUG00000006001RNASEH2A10075.000Notamacropus_eugenii
ENSG00000104889RNASEH2A10070.000ENSOPRG00000004811RNASEH2A10070.000Ochotona_princeps
ENSG00000104889RNASEH2A9991.304ENSODEG00000009772RNASEH2A10087.000Octodon_degus
ENSG00000104889RNASEH2A9963.043ENSONIG00000018033rnaseh2a9958.117Oreochromis_niloticus
ENSG00000104889RNASEH2A9962.319ENSOANG00000009079RNASEH2A10061.184Ornithorhynchus_anatinus
ENSG00000104889RNASEH2A9965.942ENSORLG00000004042rnaseh2a10060.458Oryzias_latipes
ENSG00000104889RNASEH2A9965.942ENSORLG00020009483rnaseh2a10060.131Oryzias_latipes_hni
ENSG00000104889RNASEH2A9965.942ENSORLG00015007548rnaseh2a10060.131Oryzias_latipes_hsok
ENSG00000104889RNASEH2A9964.493ENSOMEG00000016454rnaseh2a9864.961Oryzias_melastigma
ENSG00000104889RNASEH2A9989.130ENSOGAG00000012214RNASEH2A10084.000Otolemur_garnettii
ENSG00000104889RNASEH2A9991.429ENSOARG00000010721RNASEH2A10086.333Ovis_aries
ENSG00000104889RNASEH2A10098.997ENSPPAG00000028092RNASEH2A10098.997Pan_paniscus
ENSG00000104889RNASEH2A9990.000ENSPPRG00000010585RNASEH2A10086.000Panthera_pardus
ENSG00000104889RNASEH2A9988.406ENSPTIG00000013366RNASEH2A10085.333Panthera_tigris_altaica
ENSG00000104889RNASEH2A10098.328ENSPTRG00000010542RNASEH2A10098.328Pan_troglodytes
ENSG00000104889RNASEH2A10096.000ENSPANG00000034495RNASEH2A10096.000Papio_anubis
ENSG00000104889RNASEH2A9965.942ENSPKIG00000009756rnaseh2a10062.295Paramormyrops_kingsleyae
ENSG00000104889RNASEH2A6561.224ENSPSIG00000012039RNASEH2A10061.224Pelodiscus_sinensis
ENSG00000104889RNASEH2A9762.222ENSPMGG00000023392rnaseh2a10063.922Periophthalmus_magnuspinnatus
ENSG00000104889RNASEH2A9991.304ENSPEMG00000018009Rnaseh2a10084.437Peromyscus_maniculatus_bairdii
ENSG00000104889RNASEH2A9967.143ENSPMAG00000009060rnaseh2a9860.066Petromyzon_marinus
ENSG00000104889RNASEH2A9975.714ENSPCIG00000014119RNASEH2A10066.234Phascolarctos_cinereus
ENSG00000104889RNASEH2A9965.942ENSPFOG00000012627rnaseh2a10060.065Poecilia_formosa
ENSG00000104889RNASEH2A9965.942ENSPLAG00000015901rnaseh2a10065.882Poecilia_latipinna
ENSG00000104889RNASEH2A6756.311ENSPLAG00000018723-9056.311Poecilia_latipinna
ENSG00000104889RNASEH2A6756.796ENSPMEG00000009032-9356.796Poecilia_mexicana
ENSG00000104889RNASEH2A9965.942ENSPMEG00000000647rnaseh2a10066.275Poecilia_mexicana
ENSG00000104889RNASEH2A9966.667ENSPREG00000015015rnaseh2a10060.797Poecilia_reticulata
ENSG00000104889RNASEH2A9998.540ENSPPYG00000009608RNASEH2A10097.333Pongo_abelii
ENSG00000104889RNASEH2A9990.580ENSPCAG00000015319RNASEH2A10087.333Procavia_capensis
ENSG00000104889RNASEH2A9994.286ENSPCOG00000003686RNASEH2A10087.333Propithecus_coquereli
ENSG00000104889RNASEH2A9992.857ENSPVAG00000014703RNASEH2A10069.231Pteropus_vampyrus
ENSG00000104889RNASEH2A9964.286ENSPNYG00000023986rnaseh2a10053.698Pundamilia_nyererei
ENSG00000104889RNASEH2A9966.667ENSPNAG00000021017rnaseh2a10059.804Pygocentrus_nattereri
ENSG00000104889RNASEH2A9994.286ENSRNOG00000003504Rnaseh2a10085.099Rattus_norvegicus
ENSG00000104889RNASEH2A10096.333ENSRBIG00000023554RNASEH2A10096.333Rhinopithecus_bieti
ENSG00000104889RNASEH2A10096.333ENSRROG00000043799RNASEH2A10096.333Rhinopithecus_roxellana
ENSG00000104889RNASEH2A8836.567YNL072WRNH2018440.909Saccharomyces_cerevisiae
ENSG00000104889RNASEH2A9997.101ENSSBOG00000033164RNASEH2A10095.000Saimiri_boliviensis_boliviensis
ENSG00000104889RNASEH2A9975.714ENSSHAG00000015552RNASEH2A10066.452Sarcophilus_harrisii
ENSG00000104889RNASEH2A9967.391ENSSFOG00015009692rnaseh2a9962.458Scleropages_formosus
ENSG00000104889RNASEH2A9966.667ENSSMAG00000013986rnaseh2a9959.450Scophthalmus_maximus
ENSG00000104889RNASEH2A9964.493ENSSDUG00000005280rnaseh2a9959.450Seriola_dumerili
ENSG00000104889RNASEH2A9964.493ENSSLDG00000023766rnaseh2a10058.117Seriola_lalandi_dorsalis
ENSG00000104889RNASEH2A9962.319ENSSPAG00000012769rnaseh2a10057.468Stegastes_partitus
ENSG00000104889RNASEH2A9992.857ENSSSCG00000013737RNASEH2A10087.043Sus_scrofa
ENSG00000104889RNASEH2A9965.217ENSTRUG00000000049rnaseh2a10057.742Takifugu_rubripes
ENSG00000104889RNASEH2A9965.942ENSTNIG00000004533rnaseh2a9958.766Tetraodon_nigroviridis
ENSG00000104889RNASEH2A9992.857ENSTTRG00000003592RNASEH2A10092.488Tursiops_truncatus
ENSG00000104889RNASEH2A10092.958ENSUAMG00000019593RNASEH2A10092.958Ursus_americanus
ENSG00000104889RNASEH2A9992.857ENSUMAG00000006254-7390.517Ursus_maritimus
ENSG00000104889RNASEH2A9968.116ENSXETG00000004762rnaseh2a9862.290Xenopus_tropicalis
ENSG00000104889RNASEH2A10066.197ENSXCOG00000013485rnaseh2a10066.197Xiphophorus_couchianus
ENSG00000104889RNASEH2A9965.942ENSXMAG00000006953rnaseh2a10060.656Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding-IEAFunction
GO:0004523RNA-DNA hybrid ribonuclease activity21873635.IBAFunction
GO:0004523RNA-DNA hybrid ribonuclease activity21177858.IDAFunction
GO:0004540ribonuclease activity9789007.TASFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006260DNA replication21177858.TASProcess
GO:0006298mismatch repair21873635.IBAProcess
GO:0006298mismatch repair23603115.IDAProcess
GO:0006401RNA catabolic process21177858.IDAProcess
GO:0032299ribonuclease H2 complex21873635.IBAComponent
GO:0032299ribonuclease H2 complex21177858.IDAComponent
GO:0043137DNA replication, removal of RNA primer21873635.IBAProcess
GO:0046872metal ion binding-IEAFunction
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
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