EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19242824	Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India.	Med Oncol	2010 Jun	Gangawar R	doi: 10.1007/s12032-009-9187-y
20351547	Association between polymorphisms of ERCC1 and XPD and clinical response to platinum-based chemotherapy in advanced non-small cell lung cancer.	Am J Clin Oncol	2010 Oct	Li F	doi: 10.1097/COC.0b013e3181b9cedc.
26918371	Roles of XRCC1/XPD/ERCC1 Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization.	Genet Test Mol Biomarkers	2016 Apr	Wang XC	doi: 10.1089/gtmb.2015.0267
22116596	Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population.	Mol Cell Biochem	2012 Mar	Sobti RC	doi: 10.1007/s11010-011-1152-3
12451985	Nucleotide excision repair protein levels vis-�-vis anticancer drug resistance in 60 human tumor cell lines.	Ai Zheng	2002 Mar	Chen ZP	-
27069143	Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.	Anticancer Res	2016 Apr	Chang WS	-
23028604	Impact of two common xeroderma pigmentosum group D (XPD) gene polymorphisms on risk of prostate cancer.	PLoS One	2012	Mi Y	doi: 10.1371/journal.pone.0044756
20649433	Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma.	Genet Test Mol Biomarkers	2010 Aug	Engin AB	doi: 10.1089/gtmb.2009.0195.
19895736	[Correlation of XPD gene with susceptibility to gastric cancer].	Ai Zheng	2009 Nov	Zhang CZ	-
20111903	Associations between XPD polymorphisms and risk of breast cancer: a meta-analysis.	Breast Cancer Res Treat	2010 Aug	Jiang Z	doi: 10.1007/s10549-010-0751-0
25715450	[DNA repair XRCC1, XPD genes polymorphism as associated with the development of bladde r cancer and renal cell carcinoma].	Genetika	2014 Apr	Akhmadishina LZ	-
24556168	Association between ERCC2 Lys751Gln polymorphism and lung cancer risk: a meta-analysis involving 23,370 subjects.	Twin Res Hum Genet	2014 Apr	Tan X	doi: 10.1017/thg.2014.4
21643959	Impact of DNA repair genes polymorphism (XPD and XRCC1) on the risk of breast cancer in Egyptian female patients.	Mol Biol Rep	2012 Feb	Hussien YM	doi: 10.1007/s11033-011-0935-7
15298945	XPD polymorphism and risk of subsequent cancer in individuals with nonmelanoma skin cancer.	Cancer Epidemiol Biomarkers Prev	2004 Aug	Brewster AM	-
26659720	Increased expression of ERCC2 gene in head and neck cancer is associated with aggressive tumors: a systematic review and case-control study.	Int J Biol Markers	2016 Feb 28	Zafeer M	doi: 10.5301/jbm.5000186.
25537147	Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study.	Clin Exp Med	2016 Feb	Shadrina AS	doi: 10.1007/s10238-014-0329-y
17687452	Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire.	Environ Health Perspect	2007 Aug	Applebaum KM	-
23680703	A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population.	Mutagenesis	2013 Jul	Chu H	doi: 10.1093/mutage/get023
28489582	Association between the ERCC2 Asp312Asn polymorphism and risk of cancer.	Oncotarget	2017 Jul 18	Xiao F	doi: 10.18632/oncotarget.17290.
30462913	THE STUDY OF POLYMORPHISMS OF XPD GENE A751C IN LUNG CANCER PATIENTS WITH DIFFERENT CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF TUMOR.	Vopr Onkol	2016	Dmitrieva AI	-
21390502	DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.	Mol Biol Rep	2011 Nov	Engin AB	doi: 10.1007/s11033-011-0690-9
18415712	Polymorphisms of the XRCC1 and XPD genes and breast cancer risk: a case-control study.	Pathol Oncol Res	2008 Jun	Kipikasov� L	doi: 10.1007/s12253-008-9034-z
20677654	[The association of XPD G312A polymorphism with lung cancer risk: a meta-analysis].	Zhongguo Fei Ai Za Zhi	2010 May	Mei C	doi: 10.3779/j.issn.1009-3419.2010.05.27.
23973729	Genetic polymorphisms of xeroderma pigmentosum group D gene Asp312Asn and Lys751Gln and susceptibility to prostate cancer: a systematic review and meta-analysis.	Gene	2013 Nov 10	Ma Q	doi: 10.1016/j.gene.2013.08.053
21890746	Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent.	Cancer Epidemiol Biomarkers Prev	2011 Nov	Zhong S	doi: 10.1158/1055-9965.EPI-11-0520
16054878	Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: an appraisal.	DNA Repair (Amst)	2005 Sep 28	Clarkson SG	-
22179996	Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis.	Genet Mol Res	2011 Nov 22	Yuan H	doi: 10.4238/2011.November.22.6.
24347488	Xeroderma pigmentosum complementation group D (XPD) gene polymorphisms contribute to bladder cancer risk: a meta-analysis.	Tumour Biol	2014 Apr	Li SX	doi: 10.1007/s13277-013-1519-z
23977265	Predictive value of XPD polymorphisms on platinum-based chemotherapy in non-small cell lung cancer: a systematic review and meta-analysis.	PLoS One	2013 Aug 19	Qiu M	doi: 10.1371/journal.pone.0072251
18347182	Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.	Clin Cancer Res	2008 Mar 15	Tibaldi C	doi: 10.1158/1078-0432.CCR-07-1364.
19458053	Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population.	Clin Cancer Res	2009 Jun 1	Wu W	doi: 10.1158/1078-0432.CCR-08-2715
21751184	SNP-SNP interactions between DNA repair genes were associated with breast cancer risk in a Korean population.	Cancer	2012 Feb 1	Han W	doi: 10.1002/cncr.26220
24933002	Common variants of xeroderma pigmentosum genes and prostate cancer risk.	Gene	2014 Aug 10	Mirecka A	doi: 10.1016/j.gene.2014.06.026
24402573	Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women.	Tumour Biol	2014 Apr	Smolarz B	doi: 10.1007/s13277-013-1461-0
20204500	XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects.	Breast Cancer Res Treat	2010 Nov	Qiu LX	doi: 10.1007/s10549-010-0813-3
25722380	Effect of BRCA1 and XPG mutations on treatment response to trabectedin and pegylated liposomal doxorubicin in patients with advanced ovarian cancer: exploratory analysis of the phase 3 OVA-301 study.	Ann Oncol	2015 May	Monk BJ	doi: 10.1093/annonc/mdv071
17009404	Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy.	World J Gastroenterol	2006 Oct 7	Zarate RN	-
25469049	Xeroderma pigmentosum group D polymorphisms and esophageal cancer susceptibility: a meta-analysis based on case-control studies.	World J Gastroenterol	2014 Nov 28	Yang R	doi: 10.3748/wjg.v20.i44.16765.
17363013	XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer.	Mutat Res	2007 Jun 1	Hansen RD	-
19109787	Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.	Methods Mol Biol	2009	Jiang J	doi: 10.1007/978-1-59745-416-2_16.
24504678	Complex association between ERCC2 gene polymorphisms, gender, smoking and the susceptibility to bladder cancer: a meta-analysis.	Tumour Biol	2014 Jun	Wu Y	doi: 10.1007/s13277-014-1682-x
18559563	Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer.	Cancer Epidemiol Biomarkers Prev	2008 Jun	Duell EJ	doi: 10.1158/1055-9965.EPI-07-2797.
24157118	Lys751Gln XPD and Arg399Gln XRCC1 in Romanians. Association with sporadic colorectal cancer risk and different stages of carcinomas.	Chirurgia (Bucur)	2013 Sep-Oct	Procopciuc LM	-
21129812	Assessment of XPD Lys751Gln and XRCC1 T-77C polymorphisms in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy.	Lung Cancer	2011 Jul	Liu L	doi: 10.1016/j.lungcan.2010.11.004
15754315	Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.	Mol Carcinog	2005 Apr	Buch S	-
21075476	No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: a meta-analysis.	Lung Cancer	2011 Jun	Yin M	doi: 10.1016/j.lungcan.2010.10.011
26782397	Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer.	Genet Mol Res	2015 Dec 21	Yu WH	doi: 10.4238/2015.December.21.25.
24338713	The association between the ERCC1/2 polymorphisms and the clinical outcomes of the platinum-based chemotherapy in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis.	Tumour Biol	2014 Apr	Yang Y	doi: 10.1007/s13277-013-1493-5
21601580	HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population.	Mutat Res	2011 Aug 1	Yin J	doi: 10.1016/j.mrfmmm.2011.05.003
20981556	ERCC2 Lys751Gln and Asp312Asn polymorphisms and gastric cancer risk: a meta-analysis.	J Cancer Res Clin Oncol	2011 Jun	Chen B	doi: 10.1007/s00432-010-0956-y
20514470	Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk.	Oncol Rep	2010 Jul	Gao W	-
16458430	The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.	Cancer Lett	2007 Jan 8	Jiao L	-
25596702	Prognostic value of ERCC1, ERCC2, XRCC1, and TP53 single nucleotide polymorphisms in patients with early-stage non-small cell lung cancer.	Tumour Biol	2015 Jun	Geredeli C	doi: 10.1007/s13277-015-3066-2
25113251	Association between the XPD/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case-control studies.	Tumour Biol	2014 Nov	Wu KG	doi: 10.1007/s13277-014-2379-x
20842450	Effects of selected genetic polymorphisms in xeroderma pigmentosum complementary group D on gastric cancer.	Mol Biol Rep	2011 Mar	Chen Z	doi: 10.1007/s11033-010-0258-0
27173253	Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer.	Genet Mol Res	2016 Apr 26	Zheng DL	doi: 10.4238/gmr.15027384.
23996617	Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy.	J Surg Oncol	2013 Dec	Huang MY	doi: 10.1002/jso.23422
18081788	Protein expression levels of excision repair cross-complementation group 1 and xeroderma pigmentosum D correlate with response to platinum-based chemotherapy in the patients with advanced epithelial ovarian cancer.	Int J Gynecol Cancer	2008 Sep-Oct	Lin K	-
19669592	XPD Lys(751)Gln and Asp (312)Asn polymorphisms and bladder cancer risk: a meta-analysis.	Mol Biol Rep	2010 Jan	Li C	doi: 10.1007/s11033-009-9693-1
24083550	Polymorphism of ERCC2 Asp312Asn with lung cancer risk: evidence from 20,101 subjects.	Genet Test Mol Biomarkers	2014 Jan	Tan X	doi: 10.1089/gtmb.2013.0296
18365755	Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.	Eur J Epidemiol	2008	Covolo L	doi: 10.1007/s10654-008-9238-2.
21278243	ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis.	Clin Cancer Res	2011 Mar 15	Yin M	doi: 10.1158/1078-0432.CCR-10-2169
21667112	XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case-control studies.	Mol Biol Rep	2012 Mar	Ding DP	doi: 10.1007/s11033-011-1005-x
16835333	Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.	Cancer Epidemiol Biomarkers Prev	2006 Jul	Hu Z	-
18349268	DNA repair gene XPD polymorphisms and cancer risk: a meta-analysis based on 56 case-control studies.	Cancer Epidemiol Biomarkers Prev	2008 Mar	Wang F	doi: 10.1158/1055-9965.EPI-07-2507.
19561388	Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population.	Tohoku J Exp Med	2009 Jul	Sliwinski T	-
25089939	Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus.	Biomarkers	2014 Sep	Ramaniuk VP	doi: 10.3109/1354750X.2014.943291
24023723	ERCC1 and ERCC2 variants predict survival in gastric cancer patients.	PLoS One	2013 Sep 2	Li Y	doi: 10.1371/journal.pone.0071994
11751380	A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer.	Cancer Res	2001 Dec 15	Park DJ	-
23534729	XPD Lys751Gln and Asp312Asn polymorphisms and gastric cancer susceptibility: a meta-analysis of case-control studies.	Asian Pac J Cancer Prev	2013	Yin QH	-
20571908	MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study.	Mol Biol Rep	2011 Feb	Sliwinski T	doi: 10.1007/s11033-010-0224-x
26617899	Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population.	Int J Clin Exp Pathol	2015 Sep 1	Sun Y	-
25812040	Single nucleotide polymorphisms in the DNA repair genes in HPV-positive cervical cancer.	Eur J Cancer Prev	2016 May	Bajpai D	doi: 10.1097/CEJ.0000000000000159.
21614524	Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis.	Mol Biol Rep	2012 Jan	Feng Z	doi: 10.1007/s11033-011-0710-9
20627704	ERCC2 Lys751Gln polymorphism is associated with lung cancer among Caucasians.	Eur J Cancer	2010 Sep	Zhang J	doi: 10.1016/j.ejca.2010.05.008
17913280	Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer.	Lung Cancer	2008 Feb	Raaschou-Nielsen O	-
20127278	The association between ERCC2 Asp312Asn polymorphism and breast cancer risk: a meta-analysis involving 22,766 subjects.	Breast Cancer Res Treat	2010 Aug	Yao L	doi: 10.1007/s10549-010-0754-x
21404106	A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research.	Invest New Drugs	2012 Jun	Oh DY	doi: 10.1007/s10637-011-9651-3
25308691	Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non-small cell lung cancer in East Chinese Han population.	Clin Respir J	2016 May	Du Y	doi: 10.1111/crj.12218
21793320	Significant association of XPD Asp312Asn polymorphism with breast cancer in Taiwanese patients.	Chin J Physiol	2010 Apr 30	Wang HC	-
26253951	Use a survival model to correlate single-nucleotide polymorphisms of DNA repair genes with radiation dose-response in patients with non-small cell lung cancer.	Radiother Oncol	2015 Oct	Jin JY	doi: 10.1016/j.radonc.2015.07.024
15679883	Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan.	BMC Cancer	2005 Jan 28	Yeh CC	-
26985954	Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population.	Genet Mol Res	2016 Mar 11	Zhao R	doi: 10.4238/gmr.15017263.
19846926	Significant association of XPD codon 312 single nucleotide polymorphism with bladder cancer susceptibility in Taiwan.	Anticancer Res	2009 Oct	Chang CH	-
23028453	The effect of XPD/ERCC2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis.	PLoS One	2012	Xue H	doi: 10.1371/journal.pone.0043431
19429237	DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk.	Toxicol Lett	2009 May 22	Andrew AS	doi: 10.1016/j.toxlet.2009.01.013
18778871	Stratification for smoking in case-cohort studies of genetic polymorphisms and lung cancer.	Lung Cancer	2009 Mar	Sorensen M	doi: 10.1016/j.lungcan.2008.06.016
26124006	Association between polymorphisms of BAG-1 and XPD and chemotherapy sensitivity in advanced non-small-cell lung cancer patients treated with vinorelbine combined cisplatin regimen.	Tumour Biol	2015 Dec	Li P	doi: 10.1007/s13277-015-3672-z
22479369	Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.	PLoS One	2012	Wu W	doi: 10.1371/journal.pone.0033200
25117088	Polymorphisms in the DNA repair gene ERCC2/XPD and breast cancer risk: a HapMap-based case-control study among Han Women in a Chinese less-developed area.	Genet Test Mol Biomarkers	2014 Oct	Wang T	doi: 10.1089/gtmb.2014.0028
24535265	The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer.	Mol Biol Rep	2014	Xiong T	doi: 10.1007/s11033-014-3121-x
20229274	Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population.	J Cancer Res Clin Oncol	2010 Oct	Wang J	doi: 10.1007/s00432-010-0809-8
24716840	MnSOD rs4880 and XPD rs13181 polymorphisms predict the survival of breast cancer patients treated with adjuvant tamoxifen.	Acta Oncol	2014 Jun	Tengstrom M	doi: 10.3109/0284186X.2014.892210
26349749	The R156R ERCC2 polymorphism as a risk factor of endometrial cancer.	Tumour Biol	2016 Feb	Michalska MM	doi: 10.1007/s13277-015-4040-8
20651612	ERCC2/XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case-control studies.	J Thorac Oncol	2010 Sep	Zhan P	doi: 10.1097/JTO.0b013e3181e7fe2a.
18085999	Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome.	Pharmacogenomics	2007 Dec	Le Morvan V	-
17693188	Polymorphisms of the DNA gene XPD and risk of bladder cancer in a Southeastern Chinese population.	Cancer Genet Cytogenet	2007 Aug	Shao J	-
21541661	Lack of association between XPD Lys751Gln and Asp312Asn polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.	Int J Colorectal Dis	2011 Oct	Zhang Y	doi: 10.1007/s00384-011-1222-8
22994779	GSTP1, ERCC1 and ERCC2 polymorphisms, expression and clinical outcome of oxaliplatin-based adjuvant chemotherapy in colorectal cancer in Chinese population.	Asian Pac J Cancer Prev	2012	Li HY	-
18459458	XPD Lys751Gln polymorphism analysis in women with sporadic breast cancer.	Pol J Pathol	2007	Romanowicz-Makowska H	-
17504986	Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer.	Clin Cancer Res	2007 May 15	Giachino DF	-
27051038	Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer.	Genet Mol Res	2016 Mar 31	He MG	doi: 10.4238/gmr.15017879.
22536360	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.	PLoS One	2012	Hu YY	doi: 10.1371/journal.pone.0035220
12435843	ERCC2/XPD gene polymorphisms and cancer risk.	Mutagenesis	2002 Nov	Benhamou S	-
24140460	HapMap-based study identifies risk sub-region on chromosome 19q13.3 in relation to lung cancer among Chinese.	Cancer Epidemiol	2013 Dec	Yin J	doi: 10.1016/j.canep.2013.09.016
11891028	Lys751Gln polymorphism in the DNA repair gene XPD and risk of primary lung cancer.	Lung Cancer	2002 Apr	Park JY	-
22890093	Polymorphisms in XPD and hOGG1 and prostate cancer risk: a meta-analysis.	Urol Int	2012	Zhu S	doi: 10.1159/000339603
18454848	DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk.	Mol Cancer	2008 May 2	Bernard-Gallon D	doi: 10.1186/1476-4598-7-36.
25391773	Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population.	Mol Biol Rep	2015 Mar	Paszkowska-Szczur K	doi: 10.1007/s11033-014-3824-z
26125734	Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer.	Genet Mol Res	2015 May 22	Dong Y	doi: 10.4238/2015.May.22.8.
18044339	[Polymorphism Lys751Gln of XPD gene and breast cancer risk in women].	Pol Merkur Lekarski	2007 Aug	Romanowicz-Makowska H	-
12151350	DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population.	Carcinogenesis	2002 Aug	Chen S	-
22579466	No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese.	Gene	2012 Jul 15	Yin J	doi: 10.1016/j.gene.2012.04.072
19041121	Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India.	Urology	2009 Mar	Gangwar R	doi: 10.1016/j.urology.2008.09.043
26191265	Genetic variability of genes in NER pathway influences the treatment outcome of gastric cancer.	Int J Clin Exp Pathol	2015 May 1	Xue MH	-
23317245	Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population.	Asian Pac J Cancer Prev	2012	Gan Y	-
18534129	Genetic polymorphisms in the DNA repair enzyme ERCC2 and breast tumour risk in a Chinese population.	J Int Med Res	2008 May-Jun	Li J	-
17498557	A haplotype encompassing the variant allele of DNA repair gene polymorphism ERCC2/XPD Lys751Gln but not the variant allele of Asp312Asn is associated with risk of lung cancer in a northeastern Chinese population.	Cancer Genet Cytogenet	2007 May	Yin J	-
24101192	XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: a meta-analysis.	Tumour Biol	2014 Mar	Yan Y	doi: 10.1007/s13277-013-1256-3
19914098	DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of a pilot study.	Urol Oncol	2011 Nov-Dec	Dhillon VS	doi: 10.1016/j.urolonc.2009.08.013
12692111	Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.	Cancer Epidemiol Biomarkers Prev	2003 Apr	Zhou W	-
24362511	Meta-analysis on the association of nucleotide excision repair gene XPD A751C variant and cancer susceptibility among Indian population.	Mol Biol Rep	2014 Feb	Mandal RK	doi: 10.1007/s11033-013-2910-y
11960912	The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk.	Carcinogenesis	2002 Apr	Hou SM	-
26898429	Single nucleotide polymorphisms in DNA repair genes and the risk of laryngeal cancer: A meta-analysis.	Biomed Pharmacother	2016 Mar	Li F	doi: 10.1016/j.biopha.2015.12.019
25520091	The XPD Lys751Gln polymorphism has predictive value in colorectal cancer patients receiving oxaliplatin-based chemotherapy: a systemic review and meta-analysis.	Asian Pac J Cancer Prev	2014	Qian YY	-
25542228	Genetic polymorphisms of DNA repair pathways influence the response to chemotherapy and overall survival of gastric cancer.	Tumour Biol	2015 Apr	Zhou J	doi: 10.1007/s13277-014-2936-3
24652592	XPD Lys751Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis.	Tumour Biol	2014 Jul	Cui J	doi: 10.1007/s13277-014-1835-y
19724896	Proteins and single nucleotide polymorphisms involved in apoptosis, growth control, and DNA repair predict cisplatin sensitivity in head and neck cancer cell lines.	Int J Mol Med	2009 Oct	Farnebo L	-
17695467	Association of XPD polymorphisms with prostate cancer in Taiwanese patients.	Anticancer Res	2007 Jul-Aug	Bau DT	-
23771356	Genetic polymorphisms of xeroderma pigmentosum group D and prostate cancer risk: a meta-analysis.	J Cancer Res Ther	2013 Apr-Jun	Zhu H	doi: 10.4103/0973-1482.113345.
25835182	An association of selected ERCC2 and ERCC5 genes polymorphisms, the level of oxidative DNA damage and its repair efficiency with a risk of colorectal cancer in Polish population.	Cancer Biomark	2015	Kabzinski J	doi: 10.3233/CBM-150488.
24390613	Association of single nucleotide polymorphisms in ERCC2 gene and their haplotypes with esophageal squamous cell carcinoma.	Tumour Biol	2014 May	Zhang Y	doi: 10.1007/s13277-013-1553-x
20354818	The association between XPD Asp312Asn polymorphism and lung cancer risk: a meta-analysis including 16,949 subjects.	Med Oncol	2011 Sep	Zhang J	doi: 10.1007/s12032-010-9501-8
16319991	Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer.	Breast Cancer Res Treat	2006 Jan	Brewster AM	-
23044807	Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus.	Eur J Gastroenterol Hepatol	2013 Feb	Gulnaz A	doi: 10.1097/MEG.0b013e328359a775.
21627375	Lack of any relationship between chemotherapy toxicity in non-small cell lung cancer cases and polymorphisms in XRCC1 codon 399 or XPD codon 751.	Asian Pac J Cancer Prev	2011	Li Y	-
24716924	Interaction of XRCC1 and XPD gene polymorphisms with lifestyle and environmental factors regarding susceptibility to lung cancer in a high incidence population in North East India.	Asian Pac J Cancer Prev	2014	Saikia BJ	-
20863780	Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population.	Cancer Epidemiol	2011 Apr	Yuan T	doi: 10.1016/j.canep.2010.08.008
23740134	Role of XRCC3, XRCC1 and XPD single-nucleotide polymorphisms in survival outcomes following adjuvant chemotherapy in early stage breast cancer patients.	Clin Transl Oncol	2014 Feb	Castro E	doi: 10.1007/s12094-013-1055-8
15886521	Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer.	Exp Mol Med	2005 Apr 30	Lee SA	-
24531312	Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population.	Sci Rep	2014 Feb 17	Ni M	doi: 10.1038/srep04112.
22644997	XPD Asp312Asn polymorphism is a risk factor for prostate cancer.	J Cancer Res Clin Oncol	2012 Oct	Liao SG	-
15090466	Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients.	Carcinogenesis	2004 Sep	Shi Q	-
24845027	Comprehensive assessment of the association between XPD rs13181 polymorphism and lung cancer risk.	Tumour Biol	2014 Aug	Wu HY	doi: 10.1007/s13277-014-1948-3
19466538	The polymorphism of DNA repair gene ERCC2/XPD Arg156Arg and susceptibility to breast cancer in a Chinese population.	Biochem Genet	2009 Aug	Yin J	doi: 10.1007/s10528-009-9246-2
21726821	Chemotherapy-induced neutropenia does not correlate with DNA repair gene polymorphisms and treatment efficacy in advanced non-small-cell lung cancer patients.	Clin Lung Cancer	2011 Jul	Iranzo V	doi: 10.1016/j.cllc.2011.03.023
24443924	Association of XPD Lys751Gln polymorphism with head and neck cancer susceptibility: evidence from 11,443 subjects.	Diagn Pathol	2014 Jan 20	Lin H	doi: 10.1186/1746-1596-9-15.
23390054	Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back.	Int J Cancer	2013 Aug 15	Avan A	doi: 10.1002/ijc.28078
18267032	ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study.	BMC Cancer	2008 Feb 12	Huang MY	doi: 10.1186/1471-2407-8-50.
26254397	Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotype to Gastric Cancer Risk in Taiwan.	Anticancer Res	2015 Sep	Ji HX	-
20070155	DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India.	DNA Cell Biol	2010 Apr	Mandal RK	doi: 10.1089/dna.2009.0956.
12740916	Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population.	Int J Cancer	2003 Jul 10	Liang G	-
21178723	ERCC2/XPD polymorphisms and lung cancer risk.	J Thorac Oncol	2011 Jan	Christiani DC	doi: 10.1097/JTO.0b013e318200e058.
27819744	Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer.	Genet Mol Res	2016 Nov 3	Liu HX	doi: 10.4238/gmr15048813.
19492231	XPD polymorphisms, cigarette smoking, and bladder cancer risk: a meta-analysis.	J Toxicol Environ Health A	2009	Wang M	doi: 10.1080/15287390902841029.
27504877	Identification and Functional Testing of ERCC2 Mutations in a Multi-national Cohort of Patients with Familial Breast- and Ovarian Cancer.	PLoS Genet	2016 Aug 9	Rump A	doi: 10.1371/journal.pgen.1006248
28230823	Polymorphism of DNA repair gene XPD Lys751Gln and chromosome aberrations in lymphocytes of thyroid cancer patients exposed to ionizing radiation due to the Chornobyl accident.	Exp Oncol	2016 Dec	Shkarupa VM	-
27888704	Association of R156R single nucleotide polymorphism of the ERCC2 gene with the susceptibility to ovarian cancer.	Eur J Obstet Gynecol Reprod Biol	2017 Jan	Romanowicz H	doi: 10.1016/j.ejogrb.2016.11.012
27607585	Exploratory analysis of ERCC2 DNA methylation in survival among pediatric medulloblastoma patients.	Cancer Epidemiol	2016 Oct	Banfield E	doi: 10.1016/j.canep.2016.08.020
27111033	Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.	Nat Genet	2016 Jun	Kim J	doi: 10.1038/ng.3557
27908619	Correlation of DNA Repair Gene Polymorphisms With Clinical Outcome in Patients With Locally Advanced Non-Small-Cell Lung Cancer Receiving Induction Chemotherapy Followed by Surgery.	Clin Lung Cancer	2017 Mar	Santarpia M	doi: 10.1016/j.cllc.2016.08.007
27863412	Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer.	Oncotarget	2016 Dec 27	Zhang W	doi: 10.18632/oncotarget.13361.
27588464	Predictive value of XPG rs2296147T>C polymorphism on clinical outcomes of cancer patients.	Oncotarget	2016 Oct 4	Wang Y	doi: 10.18632/oncotarget.11664.
28223548	Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.	Oncotarget	2017 Jul 25	Wu Y	doi: 10.18632/oncotarget.15394.
29544444	Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.	BMC Cancer	2018 Mar 15	Hardi H	doi: 10.1186/s12885-018-4214-z.
30194171	Studies of Correlations Between Single Nucleotide Polymorphisms of DNA Repair Genes and Endometrial Cancer in Polish Women.	Anticancer Res	2018 Sep	Smolarz B	doi: 10.21873/anticanres.12846.
30225185	DNA Repair Gene XRCC1 and XPD Polymorphisms and Gastric Cancer Risk: A Case-Control Study Outcome from Kashmir, India.	Anal Cell Pathol (Amst)	2018 Aug 26	Nissar B	doi: 10.1155/2018/3806514
30535472	miR1385p modulates the expression of excision repair crosscomplementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin.	Oncol Rep	2019 Feb	Ning J	doi: 10.3892/or.2018.6907
29669843	The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility.	Biosci Rep	2018 Jun 21	Zhao Z	doi: 10.1042/BSR20180114
30581498	Predictive Value of Two Polymorphisms of ERCC2, rs13181 and rs1799793, in Clinical Outcomes of Chemotherapy in Gastric Cancer Patients: A Meta-Analysis.	Dis Markers	2018 Nov 19	Li M	doi: 10.1155/2018/3947626
28707579	The Involvement of ERCC2/XPD and ERCC6/CSB Wild Type Alleles in Protection Against Aging and Cancer.	Curr Aging Sci	2018	Savina NV	doi: 10.2174/1874609810666170707101548.
29572009	Combined effect of ERCC1 and ERCC2 polymorphisms on overall survival in non-squamous non-small-cell lung cancer patients treated with first-line pemetrexed/platinum.	Lung Cancer	2018 Apr	Liao WY	doi: 10.1016/j.lungcan.2018.01.011

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	45353098	Missense_Mutation	novel	E606Q	0.35
BLCA	chr19	45352577	Missense_Mutation	NA	H659Y	0.25
BLCA	chr19	45361540	Silent	novel	V407V	0.12
BLCA	chr19	45369122	Missense_Mutation	NA	S44L	0.2	ResIII
BLCA	chr19	45352776	Silent	novel	P624P	0.09
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.17
BLCA	chr19	45357523	Missense_Mutation	novel	A443V	0.55
BLCA	chr19	45368638	Missense_Mutation	novel	H118Y	0.53	ResIII
BLCA	chr19	45351423	3'UTR	novel		0.46
BLCA	chr19	45364313	Missense_Mutation	novel	S246Y	0.09
BLCA	chr19	45357298	Missense_Mutation	NA	T484M	0.36
BLCA	chr19	45357581	Intron	novel		0.26
BLCA	chr19	45368961	Missense_Mutation	novel	Y72C	0.35	ResIII
BLCA	chr19	45351581	3'UTR	novel		0.42
BLCA	chr19	45364885	Silent	NA	L183L	0.48
BLCA	chr19	45364079	Missense_Mutation	NA	R286W	0.37
BLCA	chr19	45357709	Intron	novel		0.14
BLCA	chr19	45364512	Missense_Mutation	novel	H210Q	0.53
BLCA	chr19	45370312	Intron	novel		0.25
BLCA	chr19	45352529	Missense_Mutation	NA	G675S	0.45
BLCA	chr19	45353098	Missense_Mutation	novel	E606Q	0.5
BLCA	chr19	45370280	Intron	novel		0.18
BLCA	chr19	45368961	Missense_Mutation	novel	Y72C	0.2	ResIII
BLCA	chr19	45353094	Missense_Mutation	NA	G607A	0.3
BLCA	chr19	45364516	Missense_Mutation	NA	Y209C	0.25
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.22
BLCA	chr19	45370197	Missense_Mutation	NA	Y14C	0.11
BLCA	chr19	45370281	Intron	novel		0.21
BLCA	chr19	45368734	Missense_Mutation	NA	E86Q	0.44	ResIII
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.38
BLCA	chr19	45357659	Silent	NA	P426P	0.18
BLCA	chr19	45357478	Missense_Mutation	novel	S458C	0.13
BLCA	chr19	45368961	Missense_Mutation	novel	Y72C	0.21	ResIII
BLCA	chr19	45369122	Missense_Mutation	NA	S44L	0.19	ResIII
BLCA	chr19	45370197	Missense_Mutation	NA	Y14C	0.17
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.34
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.36
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.62
BLCA	chr19	45364313	Missense_Mutation	novel	S246F	0.46
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.68
BLCA	chr19	45368937	Missense_Mutation	novel	I80T	0.4	ResIII
BLCA	chr19	45368734	Missense_Mutation	NA	E86Q	0.22	ResIII
BLCA	chr19	45354735	Missense_Mutation	novel	E554Q	0.45
BLCA	chr19	45358870	Intron	novel		0.29
BLCA	chr19	45368955	Missense_Mutation	NA	S74L	0.31	ResIII
BLCA	chr19	45369122	Missense_Mutation	NA	S44L	0.29	ResIII
BLCA	chr19	45370197	Missense_Mutation	NA	Y14C	0.31
BLCA	chr19	45355723	Silent	rs758510144	I495I	0.27
BLCA	chr19	45351640	Missense_Mutation	NA	Q758E	0.12
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.27
BLCA	chr19	45364429	Missense_Mutation	NA	N238S	0.48
BRCA	chr19	45351414	3'UTR	novel		0.36
BRCA	chr19	45364872	Missense_Mutation	NA	Q187R	0.38
BRCA	chr19	45357279	Silent	NA	L490L	0.14
BRCA	chr19	45358693	Intron	novel		0.46
BRCA	chr19	45370348	Intron	novel		0.44
BRCA	chr19	45351609	3'UTR	novel		0.15
BRCA	chr19	45370228	Missense_Mutation	novel	N4D	0.2
BRCA	chr19	45370229	Silent	novel	L3L	0.2
BRCA	chr19	45353241	Splice_Site	rs760834687	X586_splice	0.29
CESC	chr19	45361573	Silent	novel	P396P	0.37
CESC	chr19	45361853	Intron	novel		0.48
CESC	chr19	45351614	3'UTR	novel		0.41
CESC	chr19	45364119	Missense_Mutation	NA	R272S	0.57
CESC	chr19	45357519	Silent	novel	I444I	0.09
CESC	chr19	45370305	Intron	novel		0.97
CESC	chr19	45358758	Intron	novel		0.43
CESC	chr19	45351488	3'UTR	novel		0.33
CESC	chr19	45364086	Silent	novel	D283D	0.5
CHOL	chr19	45352529	Missense_Mutation	novel	G675C	0.48
CHOL	chr19	45361926	Intron	novel		0.5
COAD	chr19	45353133	Missense_Mutation	NA	A594D	0.22
COAD	chr19	45370168	In_Frame_Del	NA	S23del	0.35	ResIII
COAD	chr19	45357671	Silent	rs142702501	D422D	0.31
COAD	chr19	45370520	Intron	NA		0.24
COAD	chr19	45355718	Missense_Mutation	rs757432268	R497H	0.3
COAD	chr19	45364489	Missense_Mutation	NA	A218V	0.26
COAD	chr19	45352226	Missense_Mutation	NA	A725T	0.4
COAD	chr19	45361594	Silent	rs765430756	T389T	0.09
COAD	chr19	45368727	Missense_Mutation	rs777095373	R88Q	0.27	ResIII
COAD	chr19	45352631	Missense_Mutation	rs769085031	R641W	0.24
COAD	chr19	45357365	Missense_Mutation	novel	S462P	0.22
COAD	chr19	45361598	Missense_Mutation	NA	I388T	0.33
COAD	chr19	45355676	Missense_Mutation	rs772572683	R511Q	0.38
COAD	chr19	45358873	Intron	NA		0.38
COAD	chr19	45357650	Silent	NA	A429A	0.56
ESCA	chr19	45357529	Missense_Mutation	rs760834335	S441L	0.29
GBM	chr19	45364254	Silent	novel	L266L	0.22
GBM	chr19	45364879	Missense_Mutation	rs139884931	R185W	0.35
GBM	chr19	45370160	Silent	NA	R26R	0.3
GBM	chr19	45357591	Intron	novel		0.13
GBM	chr19	45361776	Intron	novel		0.38
HNSC	chr19	45351447	3'UTR	novel		0.36
HNSC	chr19	45352243	Missense_Mutation	rs533062241	Y719C	0.33
HNSC	chr19	45370562	5'UTR	novel		0.22
HNSC	chr19	45352206	Splice_Region	novel		0.44
HNSC	chr19	45368955	Nonsense_Mutation	novel	S74*	0.28	ResIII
HNSC	chr19	45357311	Missense_Mutation	rs757100147	T480A	0.3
HNSC	chr19	45352751	Missense_Mutation	novel	L633F	0.49
HNSC	chr19	45357665	Silent	novel	R424R	0.09
HNSC	chr19	45364451	Missense_Mutation	rs200895828	V231M	0.15
KIRC	chr19	45354733	Silent	novel	E554E	0.16
KIRP	chr19	45353106	Missense_Mutation	rs745695024	K603T	0.39
KIRP	chr19	45370511	Intron	novel		0.39
KIRP	chr19	45364104	Silent	rs547544775	D277D	0.19
KIRP	chr19	45365057	Silent	NA	H154H	0.48
LAML	chr19	45365129	Silent	rs757159764	V130V	0.16
LGG	chr19	45354843	Missense_Mutation	rs778075234	R518W	0.24
LGG	chr19	45352796	Missense_Mutation	NA	V618I	0.34
LIHC	chr19	45357299	Missense_Mutation	NA	T484A	0.4
LIHC	chr19	45357752	Intron	novel		0.33
LIHC	chr19	45370358	Intron	novel		0.26
LIHC	chr19	45357371	Missense_Mutation	novel	T460A	0.29
LIHC	chr19	45363890	Missense_Mutation	novel	R324P	0.5
LIHC	chr19	45352795	Missense_Mutation	NA	V618G	0.29
LUAD	chr19	45354794	Missense_Mutation	NA	G534D	0.59
LUAD	chr19	45352515	Frame_Shift_Del	novel	*F679Cfs94**	0.06
LUAD	chr19	45370266	Intron	novel		0.33
LUAD	chr19	45364328	Missense_Mutation	NA	N241I	0.55
LUAD	chr19	45357498	Missense_Mutation	NA	F451L	0.38
LUAD	chr19	45364246	Missense_Mutation	novel	K268N	0.31
LUSC	chr19	45364882	Missense_Mutation	novel	G184W	0.21
LUSC	chr19	45361612	Silent	NA	L383L	0.33
LUSC	chr19	45352268	Missense_Mutation	rs763610846	D711N	0.29
LUSC	chr19	45364835	Splice_Region	novel		0.22
LUSC	chr19	45358922	Intron	novel		0.18
LUSC	chr19	45351447	3'UTR	novel		0.35
LUSC	chr19	45355674	Missense_Mutation	novel	E512K	0.18
LUSC	chr19	45353299	Silent	NA	L567L	0.07
LUSC	chr19	45364878	Missense_Mutation	novel	R185L	0.22
LUSC	chr19	45368965	Missense_Mutation	novel	I71V	0.06	ResIII
LUSC	chr19	45353098	Missense_Mutation	novel	E606K	0.16
OV	chr19	45368719	Frame_Shift_Ins	novel	*L91Ifs10**	0.16	ResIII
OV	chr19	45354762	Missense_Mutation	novel	M545L	0.09
OV	chr19	45351379	3'UTR	rs373169640		0.31
OV	chr19	45351618	3'UTR	novel		0.17
OV	chr19	45368651	Missense_Mutation	novel	K113N	0.11	ResIII
PAAD	chr19	45364244	Missense_Mutation	NA	T269M	0.14
PAAD	chr19	45357671	Silent	rs142702501	D422D	0.09
PAAD	chr19	45358746	Intron	novel		0.21
PAAD	chr19	45364446	Silent	novel	V232V	0.14
PRAD	chr19	45353097	Missense_Mutation	novel	E606G	0.33
PRAD	chr19	45355677	Missense_Mutation	NA	R511W	0.26
PRAD	chr19	45364443	Silent	rs141816180	F233F	0.18
PRAD	chr19	45354801	Missense_Mutation	NA	P532S	0.33
SKCM	chr19	45352344	Silent	rs777919686	A685A	0.27
SKCM	chr19	45365100	Missense_Mutation	novel	S140F	0.53	ResIII
SKCM	chr19	45364476	Silent	NA	S222S	0.16
SKCM	chr19	45352316	Missense_Mutation	rs201392911	R695C	0.32
SKCM	chr19	45364448	Missense_Mutation	novel	V232F	0.29
SKCM	chr19	45353260	Silent	NA	A580A	0.37
SKCM	chr19	45352298	Missense_Mutation	NA	L701F	0.41
SKCM	chr19	45364904	Silent	NA	N176N	0.42
SKCM	chr19	45364279	Silent	novel	D257D	0.07
SKCM	chr19	45361654	Intron	novel		0.51
SKCM	chr19	45352572	Silent	rs775910108	A660A	0.13
SKCM	chr19	45361528	Silent	rs754028681	A411A	0.43
SKCM	chr19	45354736	Nonsense_Mutation	NA	Y553*	0.17
SKCM	chr19	45351406	3'UTR	novel		0.55
SKCM	chr19	45357342	Silent	NA	K469K	0.32
SKCM	chr19	45364862	Silent	novel	C190C	0.17
STAD	chr19	45364085	Missense_Mutation	novel	E284K	0.36
STAD	chr19	45352757	Missense_Mutation	rs144511865	R631C	0.11
STAD	chr19	45355677	Missense_Mutation	NA	R511W	0.09
STAD	chr19	45364918	Missense_Mutation	rs559154781	A172T	0.31
STAD	chr19	45352782	Silent	rs16979773	G622G	0.18
STAD	chr19	45352647	Splice_Region	rs145835916	A635A	0.42
STAD	chr19	45365052	Missense_Mutation	rs201294521	R156Q	0.65	ResIII
STAD	chr19	45361617	Missense_Mutation	NA	L382M	0.21
STAD	chr19	45357533	Missense_Mutation	rs768677952	A440T	0.17
STAD	chr19	45364057	Missense_Mutation	NA	R293Q	0.2
STAD	chr19	45368627	Splice_Region	rs767779002		0.63
STAD	chr19	45364326	Missense_Mutation	NA	V242I	0.23
STAD	chr19	45353262	Missense_Mutation	rs751318902	A580T	0.42
STAD	chr19	45352628	Frame_Shift_Del	novel	*D642Tfs67**	0.48
STAD	chr19	45351446	3'UTR	novel		0.23
STAD	chr19	45364091	Missense_Mutation	rs375415853	R282W	0.33
THCA	chr19	45361732	Intron	novel		0.15
THYM	chr19	45361790	Intron	novel		0.21
UCEC	chr19	45351380	3'UTR	rs750728345		0.46
UCEC	chr19	45352590	Silent	rs762985501	F654F	0.35
UCEC	chr19	45354842	Missense_Mutation	novel	R518Q	0.1
UCEC	chr19	45354766	Silent	novel	Q543Q	0.08
UCEC	chr19	45358758	Intron	novel		0.38
UCEC	chr19	45357868	Intron	novel		0.07
UCEC	chr19	45357510	Silent	NA	V447V	0.11
UCEC	chr19	45363832	Silent	novel	R343R	0.67
UCEC	chr19	45358685	Intron	novel		0.48
UCEC	chr19	45358781	Intron	novel		0.43
UCEC	chr19	45351493	3'UTR	rs149943175		0.55
UCEC	chr19	45357590	Intron	novel		0.41
UCEC	chr19	45368681	Silent	rs371383715	P103P	0.55
UCEC	chr19	45352782	Silent	rs16979773	G622G	0.5
UCEC	chr19	45357789	Intron	novel		0.6
UCEC	chr19	45361529	Missense_Mutation	novel	A411V	0.34
UCEC	chr19	45352292	Missense_Mutation	novel	D703Y	0.44
UCEC	chr19	45351561	3'UTR	rs565650029		0.44
UCEC	chr19	45364879	Missense_Mutation	rs139884931	R185W	0.38
UCEC	chr19	45363756	Missense_Mutation	novel	R369C	0.71
UCEC	chr19	45352322	Silent	novel	L693L	0.31
UCEC	chr19	45358853	Intron	novel		0.37
UCEC	chr19	45361766	Intron	novel		0.44
UCEC	chr19	45353089	Missense_Mutation	novel	D609N	0.2
UCEC	chr19	45357320	Missense_Mutation	novel	T477A	0.19
UCEC	chr19	45352570	Missense_Mutation	novel	A661V	0.29
UCEC	chr19	45355675	Silent	novel	R511R	0.44
UCEC	chr19	45365117	Silent	novel	C134C	0.33
UCEC	chr19	45368731	Missense_Mutation	novel	L87I	0.19	ResIII
UCEC	chr19	45369118	Silent	NA	G45G	0.44
UCEC	chr19	45352529	Missense_Mutation	NA	G675S	0.05
UCEC	chr19	45357303	Silent	novel	T482T	0.24
UCEC	chr19	45354727	Splice_Region	NA		0.28
UCEC	chr19	45351516	3'UTR	novel		0.43
UCEC	chr19	45352235	Missense_Mutation	rs121913026	R722W	0.19
UCEC	chr19	45352630	Missense_Mutation	rs747476170	R641Q	0.43
UCEC	chr19	45357543	Missense_Mutation	novel	S436R	0.16
UCEC	chr19	45369116	Missense_Mutation	novel	T46I	0.24	ResIII
UCEC	chr19	45352604	Missense_Mutation	novel	D650N	0.31
UCEC	chr19	45363884	Missense_Mutation	NA	A326V	0.4
UCEC	chr19	45364251	Nonsense_Mutation	novel	Q267*	0.39
UCEC	chr19	45352352	Missense_Mutation	rs41556519	R683W	0.37
UCEC	chr19	45361566	Missense_Mutation	novel	L399I	0.16
UVM	chr19	45352647	Splice_Region	rs145835916	A635A	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0712	0.027508
KIRP	DEL	0.0417	0.054726
READ	DEL	0.0667	0.23023
STAD	DEL	0.1156	0.1243
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
SARC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0058	Kaplan-Meier Survival Analysis
ACC	0.0091	Kaplan-Meier Survival Analysis
UCS	0.0019	Kaplan-Meier Survival Analysis
HNSC	0.049	Kaplan-Meier Survival Analysis
SKCM	0.0038	Kaplan-Meier Survival Analysis
LUSC	0.0091	Kaplan-Meier Survival Analysis
KIRP	0.00086	Kaplan-Meier Survival Analysis
PAAD	0.00059	Kaplan-Meier Survival Analysis
LAML	0.008	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
DLBC	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000104884 (Gene tree)
Gene ID: 2068
Gene Symbol: ERCC2
Alias: MAG|EM9|MGC102762|MGC126218|MGC126219|TFIIH|XPD
Full Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 21,082 bases
Position: chr19:45,349,837-45,370,918
Accession: 3434
Summary: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000375808	ResIII	PF04851.15	2.1e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19818408	Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit.	Protein Expr Purif	2010 Apr	Yang C	doi: 10.1016/j.pep.2009.09.021

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000586131	ERCC2-206	1015	-	ENSP00000464887	292 (aa)	-	K7EIT8
ENST00000587376	ERCC2-210	823	-	ENSP00000465593	202 (aa)	-	K7EKF3
ENST00000586737	ERCC2-208	481	-	-	- (aa)	-	-
ENST00000391945	ERCC2-204	4122	XM_011526611	ENSP00000375809	760 (aa)	XP_011524913	P18074
ENST00000391944	ERCC2-203	2334	-	ENSP00000375808	682 (aa)	-	E7EVE9
ENST00000588652	ERCC2-211	2405	-	-	- (aa)	-	-
ENST00000391941	ERCC2-201	2871	-	ENSP00000375805	706 (aa)	-	A8MX75
ENST00000586856	ERCC2-209	690	-	ENSP00000466998	109 (aa)	-	K7ENL1
ENST00000391942	ERCC2-202	1488	-	-	- (aa)	-	-
ENST00000646507	ERCC2-213	3119	-	-	- (aa)	-	-
ENST00000485403	ERCC2-205	1538	-	ENSP00000431229	405 (aa)	-	P18074
ENST00000591309	ERCC2-212	557	-	ENSP00000465207	127 (aa)	-	B4E0F6
ENST00000586441	ERCC2-207	682	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000104884's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03022	Basal transcription factors	KEGG
hsa03420	Nucleotide excision repair	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000104884	Lung Neoplasms	9E-7	23108145

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104884	rs13181	19	45351661	C	Lung Cancer (DNA repair capacity)	23108145			EFO_0001071

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104884's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104884	ERCC2	97	84.163	ENSAPOG00000000375	ercc2	99	84.163	Acanthochromis_polyacanthus
ENSG00000104884	ERCC2	99	84.389	ENSACIG00000008002	ercc2	99	84.389	Amphilophus_citrinellus
ENSG00000104884	ERCC2	97	82.733	ENSAOCG00000016153	ercc2	99	82.733	Amphiprion_ocellaris
ENSG00000104884	ERCC2	97	82.733	ENSAPEG00000016712	ercc2	99	82.733	Amphiprion_percula
ENSG00000104884	ERCC2	99	84.141	ENSATEG00000005268	ercc2	99	84.141	Anabas_testudineus
ENSG00000104884	ERCC2	100	99.413	ENSANAG00000022694	ERCC2	100	99.413	Aotus_nancymaae
ENSG00000104884	ERCC2	97	84.766	ENSACLG00000017573	ercc2	99	84.766	Astatotilapia_calliptera
ENSG00000104884	ERCC2	97	84.639	ENSAMXG00000009052	ercc2	99	84.639	Astyanax_mexicanus
ENSG00000104884	ERCC2	100	99.413	ENSCJAG00000012716	ERCC2	100	99.413	Callithrix_jacchus
ENSG00000104884	ERCC2	90	37.931	ENSCJAG00000001292	BRIP1	78	37.931	Callithrix_jacchus
ENSG00000104884	ERCC2	99	99.005	ENSCAFG00020011390	ERCC2	99	98.971	Canis_lupus_dingo
ENSG00000104884	ERCC2	87	34.677	ENSCAFG00020001919	-	50	34.677	Canis_lupus_dingo
ENSG00000104884	ERCC2	92	90.722	ENSTSYG00000026723	ERCC2	99	89.899	Carlito_syrichta
ENSG00000104884	ERCC2	99	99.502	ENSCCAG00000019831	ERCC2	99	99.160	Cebus_capucinus
ENSG00000104884	ERCC2	91	39.655	ENSCATG00000041725	BRIP1	56	39.655	Cercocebus_atys
ENSG00000104884	ERCC2	91	39.655	ENSCSAG00000005928	BRIP1	55	39.655	Chlorocebus_sabaeus
ENSG00000104884	ERCC2	71	30.605	ENSCSAVG00000002028	-	77	30.605	Ciona_savignyi
ENSG00000104884	ERCC2	91	39.655	ENSCANG00000032026	BRIP1	55	39.655	Colobus_angolensis_palliatus
ENSG00000104884	ERCC2	100	99.853	ENSCANG00000040683	ERCC2	100	99.853	Colobus_angolensis_palliatus
ENSG00000104884	ERCC2	97	79.970	ENSCSEG00000006041	ercc2	99	81.731	Cynoglossus_semilaevis
ENSG00000104884	ERCC2	99	99.005	ENSEASG00005013856	ERCC2	99	97.479	Equus_asinus_asinus
ENSG00000104884	ERCC2	98	83.609	ENSELUG00000018055	ercc2	100	83.654	Esox_lucius
ENSG00000104884	ERCC2	100	98.827	ENSFCAG00000002679	ERCC2	100	98.827	Felis_catus
ENSG00000104884	ERCC2	99	84.118	ENSFHEG00000000072	ercc2	99	84.118	Fundulus_heteroclitus
ENSG00000104884	ERCC2	98	87.097	ENSGAGG00000009493	ERCC2	100	84.050	Gopherus_agassizii
ENSG00000104884	ERCC2	100	99.853	ENSGGOG00000015842	ERCC2	100	99.853	Gorilla_gorilla
ENSG00000104884	ERCC2	97	83.958	ENSHBUG00000002187	ercc2	99	83.958	Haplochromis_burtoni
ENSG00000104884	ERCC2	99	83.113	ENSLBEG00000010573	ercc2	92	83.235	Labrus_bergylta
ENSG00000104884	ERCC2	100	99.853	ENSMFAG00000037898	ERCC2	100	99.853	Macaca_fascicularis
ENSG00000104884	ERCC2	91	39.655	ENSMFAG00000044136	BRIP1	55	39.655	Macaca_fascicularis
ENSG00000104884	ERCC2	100	99.853	ENSMMUG00000014419	ERCC2	100	99.853	Macaca_mulatta
ENSG00000104884	ERCC2	91	39.655	ENSMMUG00000009027	BRIP1	56	39.655	Macaca_mulatta
ENSG00000104884	ERCC2	100	99.853	ENSMNEG00000042641	ERCC2	100	99.853	Macaca_nemestrina
ENSG00000104884	ERCC2	91	39.655	ENSMNEG00000040728	BRIP1	69	39.655	Macaca_nemestrina
ENSG00000104884	ERCC2	91	39.655	ENSMLEG00000037601	BRIP1	55	39.655	Mandrillus_leucophaeus
ENSG00000104884	ERCC2	99	99.853	ENSMLEG00000043492	ERCC2	99	99.853	Mandrillus_leucophaeus
ENSG00000104884	ERCC2	99	84.242	ENSMAMG00000016724	ercc2	99	84.242	Mastacembelus_armatus
ENSG00000104884	ERCC2	97	84.789	ENSMZEG00005024441	ercc2	99	84.789	Maylandia_zebra
ENSG00000104884	ERCC2	100	98.827	ENSMICG00000000635	ERCC2	100	98.827	Microcebus_murinus
ENSG00000104884	ERCC2	99	81.591	ENSMMOG00000005162	ercc2	99	84.874	Mola_mola
ENSG00000104884	ERCC2	99	83.211	ENSMALG00000005990	ercc2	99	83.211	Monopterus_albus
ENSG00000104884	ERCC2	99	98.010	MGP_CAROLIEiJ_G0029287	Ercc2	99	97.944	Mus_caroli
ENSG00000104884	ERCC2	99	98.010	ENSMUSG00000030400	Ercc2	99	97.944	Mus_musculus
ENSG00000104884	ERCC2	99	98.010	MGP_PahariEiJ_G0021147	Ercc2	99	97.944	Mus_pahari
ENSG00000104884	ERCC2	99	98.010	MGP_SPRETEiJ_G0030371	Ercc2	99	97.797	Mus_spretus
ENSG00000104884	ERCC2	100	99.853	ENSPPAG00000044005	ERCC2	100	99.853	Pan_paniscus
ENSG00000104884	ERCC2	98	94.355	ENSPPRG00000000507	ERCC2	99	97.479	Panthera_pardus
ENSG00000104884	ERCC2	100	99.853	ENSPTRG00000011149	ERCC2	100	99.853	Pan_troglodytes
ENSG00000104884	ERCC2	99	99.853	ENSPANG00000032195	ERCC2	99	99.853	Papio_anubis
ENSG00000104884	ERCC2	91	39.655	ENSPANG00000022169	BRIP1	55	39.655	Papio_anubis
ENSG00000104884	ERCC2	99	79.589	ENSPKIG00000006883	ercc2	98	81.818	Paramormyrops_kingsleyae
ENSG00000104884	ERCC2	97	83.584	ENSPMGG00000000223	ercc2	99	85.577	Periophthalmus_magnuspinnatus
ENSG00000104884	ERCC2	99	84.141	ENSPLAG00000002626	ercc2	99	84.265	Poecilia_latipinna
ENSG00000104884	ERCC2	99	84.141	ENSPMEG00000002858	ercc2	99	84.265	Poecilia_mexicana
ENSG00000104884	ERCC2	99	80.597	ENSPREG00000019280	ercc2	99	81.667	Poecilia_reticulata
ENSG00000104884	ERCC2	97	84.084	ENSPNYG00000022007	ercc2	99	84.084	Pundamilia_nyererei
ENSG00000104884	ERCC2	98	83.910	ENSPNAG00000010434	ercc2	100	85.577	Pygocentrus_nattereri
ENSG00000104884	ERCC2	91	39.655	ENSRBIG00000024082	BRIP1	56	39.655	Rhinopithecus_bieti
ENSG00000104884	ERCC2	100	99.853	ENSRROG00000040423	ERCC2	100	99.853	Rhinopithecus_roxellana
ENSG00000104884	ERCC2	99	99.502	ENSSBOG00000030257	ERCC2	99	99.412	Saimiri_boliviensis_boliviensis
ENSG00000104884	ERCC2	99	78.325	ENSSMAG00000019720	ercc2	99	82.524	Scophthalmus_maximus
ENSG00000104884	ERCC2	97	83.584	ENSSDUG00000002397	ercc2	99	83.654	Seriola_dumerili
ENSG00000104884	ERCC2	97	83.434	ENSSLDG00000020353	ercc2	99	83.654	Seriola_lalandi_dorsalis
ENSG00000104884	ERCC2	99	84.389	ENSSPAG00000002074	ercc2	99	84.874	Stegastes_partitus
ENSG00000104884	ERCC2	99	83.947	ENSTRUG00000007303	ercc2	99	83.947	Takifugu_rubripes
ENSG00000104884	ERCC2	99	98.507	ENSUAMG00000019562	ERCC2	99	98.382	Ursus_americanus
ENSG00000104884	ERCC2	99	81.095	ENSXMAG00000003922	ercc2	99	81.667	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000019	regulation of mitotic recombination	21873635.	IBA	Process
GO:0000439	transcription factor TFIIH core complex	-	IEA	Component
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	21873635.	IBA	Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	TAS	Process
GO:0001666	response to hypoxia	-	IEA	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0003684	damaged DNA binding	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004672	protein kinase activity	9852112.	IDA	Function
GO:0005515	protein binding	7663514.8652557.11445587.16669699.20797633.23585563.23891004.25416956.27193682.28178521.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	20797633.23585563.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005669	transcription factor TFIID complex	27193682.	IDA	Component
GO:0005675	transcription factor TFIIH holo complex	9852112.	IDA	Component
GO:0005675	transcription factor TFIIH holo complex	7663514.	TAS	Component
GO:0005737	cytoplasm	20797633.23585563.	IDA	Component
GO:0005819	spindle	20797633.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	8663148.	IDA	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006289	nucleotide-excision repair	2835663.	IGI	Process
GO:0006289	nucleotide-excision repair	2184031.	NAS	Process
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	Process
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	Process
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	Process
GO:0006362	transcription elongation from RNA polymerase I promoter	-	TAS	Process
GO:0006363	termination of RNA polymerase I transcription	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	8663148.	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0006915	apoptotic process	8675009.	IMP	Process
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0006979	response to oxidative stress	17614221.	IMP	Process
GO:0007059	chromosome segregation	20797633.	IMP	Process
GO:0007568	aging	-	IEA	Process
GO:0008022	protein C-terminus binding	10801852.	IPI	Function
GO:0008094	DNA-dependent ATPase activity	9852112.	IDA	Function
GO:0008094	DNA-dependent ATPase activity	8663148.	TAS	Function
GO:0008283	cell proliferation	-	IEA	Process
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	21873635.	IBA	Function
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	9852112.	IDA	Function
GO:0009411	response to UV	21873635.	IBA	Process
GO:0009650	UV protection	2835663.	IGI	Process
GO:0009791	post-embryonic development	-	IEA	Process
GO:0016032	viral process	-	IEA	Process
GO:0021510	spinal cord development	-	IEA	Process
GO:0030198	extracellular matrix organization	-	IEA	Process
GO:0030282	bone mineralization	-	IEA	Process
GO:0030674	protein binding, bridging	11445587.	IPI	Function
GO:0032289	central nervous system myelin formation	-	IEA	Process
GO:0033683	nucleotide-excision repair, DNA incision	21873635.	IBA	Process
GO:0033683	nucleotide-excision repair, DNA incision	8692841.	IMP	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0035315	hair cell differentiation	11335038.	IMP	Process
GO:0040016	embryonic cleavage	-	IEA	Process
GO:0043139	5'-3' DNA helicase activity	8663148.11445587.	IDA	Function
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	21873635.	IBA	Function
GO:0043249	erythrocyte maturation	-	IEA	Process
GO:0043388	positive regulation of DNA binding	-	IEA	Process
GO:0045893	positive regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045893	positive regulation of transcription, DNA-templated	8692842.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	8692841.	IDA	Process
GO:0045951	positive regulation of mitotic recombination	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0047485	protein N-terminus binding	8652557.	IPI	Function
GO:0048568	embryonic organ development	-	IEA	Process
GO:0048820	hair follicle maturation	-	IEA	Process
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function
GO:0060218	hematopoietic stem cell differentiation	-	IEA	Process
GO:0070516	CAK-ERCC2 complex	8692842.11445587.	IDA	Component
GO:0070911	global genome nucleotide-excision repair	-	TAS	Process
GO:0071817	MMXD complex	20797633.	IDA	Component
GO:1901990	regulation of mitotic cell cycle phase transition	17088560.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.