EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20036632An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.Biochim Biophys Acta2010 Jun-JulSassi Ndoi: 10.1016/j.bbabio.2009.12.015
24885636Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner.BMC Cancer2014 May 10Xu Hdoi: 10.1186/1471-2407-14-330.
27531900miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma.Oncotarget2016 Sep 6Chen Ydoi: 10.18632/oncotarget.11252.
28280257Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical CancerMed Sci Monit Basic Res2017 Mar 10Liu L-
17310992Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer.Oncogene2007 Aug 2Wang ZH-
18367588IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells.Am J Physiol Cell Physiol2008 JunLee ELdoi: 10.1152/ajpcell.00428.2007
27124117Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.PLoS One2016 Apr 28Zhang Pdoi: 10.1371/journal.pone.0154471
20712009Intermediate conductance Ca2+ activated K+ channels are expressed and functional in breast adenocarcinomas: correlation with tumour grade and metastasis status.Histol Histopathol2010 OctHaren Ndoi: 10.14670/HH-25.1247.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1943780804Missense_MutationNAE20K0.38
BLCAchr1943769516Missense_MutationNAF325L0.29
BLCAchr1943772090SilentnovelL243L0.11
BLCAchr1943769716Splice_Regionnovel0.63
BLCAchr1943780805SilentnovelL19L0.5
BLCAchr1943772080Missense_MutationnovelT247S0.36
BLCAchr1943780784SilentnovelA26A0.47
BLCAchr1943769405Intronnovel0.08
BRCAchr1943774458Silentrs754650938Q139Q0.32
BRCAchr1943774383SilentnovelP164P0.38
BRCAchr19437809265'UTRnovel0.2
BRCAchr1943769439Splice_Regionnovel0.16
CESCchr1943767648Missense_MutationnovelE393D0.44
CESCchr1943774194Splice_RegionnovelE227E0.23
COADchr1943769453Silentrs144044337A346A0.22
COADchr1943780745SilentnovelL39L0.24
COADchr1943774376Missense_Mutationrs748681028V167M0.12
COADchr1943780821Missense_Mutationrs201019335R14H0.18
COADchr1943774217Missense_MutationnovelA220T0.08
DLBCchr1943774337Missense_MutationnovelR180G0.12
ESCAchr1943767628Missense_MutationnovelA400V0.32
ESCAchr1943772027Missense_MutationnovelK264N0.21
GBMchr1943780777Frame_Shift_DelnovelA29Hfs*600.09
GBMchr1943769466Missense_Mutationrs199638500R342H0.45
GBMchr1943772024Silentrs190256118I265I0.42
HNSCchr1943772045SilentnovelP258P0.21
HNSCchr1943767634Missense_Mutationrs201257292T398M0.54
HNSCchr1943769766Missense_MutationnovelE295K0.39
KICHchr1943772043Missense_MutationnovelG259D0.1
KIRCchr1943769452Missense_Mutationrs775470701A347T0.21
KIRCchr1943776585Frame_Shift_InsnovelL71Ifs*1620.06
KIRPchr19437810185'UTRnovel0.27
KIRPchr1943774202Missense_MutationNAV225M0.55
LGGchr1943769806Silentrs768638140L281L0.34
LIHCchr1943767707Missense_MutationNAM374V0.6
LIHCchr1943774433Missense_MutationNAG148R0.39
LIHCchr1943769449Frame_Shift_DelnovelI348Sfs*90.27
LIHCchr19437809655'UTRnovel0.58
LUADchr1943769752Missense_MutationNAH299Q0.44
LUADchr1943776631Silentrs778812990A55A0.16
LUADchr1943767614Missense_MutationnovelA405S0.5
LUADchr1943769757Missense_MutationNAV298L0.14
LUADchr1943767659SilentnovelR390R0.22
LUADchr1943780796In_Frame_Delrs751361496E22del0.25
LUADchr19437809735'UTRnovel0.23
LUSCchr1943774399Missense_MutationnovelR159H0.27
LUSCchr1943767659Missense_Mutationrs200755307R390W0.18
LUSCchr1943776552Missense_MutationNAK82E0.2
LUSCchr1943769790Missense_MutationnovelR287G0.27
LUSCchr1943769508Missense_MutationNAH328P0.14
LUSCchr1943769028Missense_Mutationrs202202107R352C0.3
OVchr1943780729Missense_MutationNAE45K0.44
OVchr1943780703Splice_Regionrs779928751S53S0.22
PAADchr1943776558Missense_MutationnovelH80D0.11
PAADchr1943774421SilentnovelL152L0.17
PRADchr1943774425SilentNAA150A0.25
READchr1943774396Frame_Shift_InsnovelL160Qfs*850.06
SARCchr19437669063'UTRnovel0.39
SKCMchr1943772024Silentrs190256118I265I0.28
SKCMchr1943774198Missense_MutationNAA226V0.24
SKCMchr1943774464SilentNAS137S0.38
SKCMchr1943774464SilentNAS137S0.33
SKCMchr1943774466Missense_MutationNAS137T0.33
SKCMchr1943772024Silentrs190256118I265I0.29
SKCMchr1943776604Silentrs766351876T64T0.1
SKCMchr1943769784SilentNAL289L0.09
SKCMchr1943767659Missense_Mutationrs200755307R390W0.15
SKCMchr1943780713Missense_MutationNAG50E0.44
SKCMchr1943768981SilentNAS367S0.48
STADchr1943774258Missense_MutationNAR206H0.59
STADchr1943776584Missense_MutationNAL71S0.42
STADchr1943774238Missense_MutationNAL213I0.19
STADchr1943776602Missense_MutationNAI65S0.34
STADchr1943774203SilentNAS224S0.27
UCECchr1943776597Missense_MutationnovelI67F0.3
UCECchr1943780831Missense_MutationnovelA11T0.2
UCECchr1943768979Missense_MutationnovelM368T0.27
UCECchr1943767695Missense_MutationNAL378M0.38
UCECchr1943769467Missense_Mutationrs762765968R342C0.4
UCECchr1943776605Missense_Mutationrs199820891T64M0.26
UCECchr19437809155'UTRrs2009154970.49
UCECchr1943769466Missense_Mutationrs199638500R342H0.2
UCECchr1943769522Missense_MutationnovelW323C0.05
UCECchr1943769413Intronnovel0.25
UCECchr1943780749Missense_MutationnovelG38E0.14
UCECchr1943769739Missense_MutationnovelD304Y0.48
UCECchr1943774283Missense_MutationnovelL198F0.36
UCECchr1943774359SilentnovelG172G0.25
UCECchr19437809985'UTRnovel0.47
UCECchr1943776549Missense_MutationNAE83Q0.15
UCECchr1943769019Missense_MutationnovelR355W0.18
UCECchr1943772102SilentnovelD239D0.34
UCECchr1943780704Missense_Mutationrs201245638S53L0.34
UCECchr1943780814SilentNAK16K0.32
UCECchr1943772071Missense_MutationnovelT250A0.35
UCECchr1943774196Missense_MutationnovelE227K0.39
UCECchr1943776588Missense_MutationnovelF70V0.31
UCECchr1943769738Missense_MutationnovelD304G0.34
UCECchr1943774472SilentnovelL135L0.26
UCECchr19437669753'UTRnovel0.53
UCECchr1943774240Missense_MutationnovelT212M0.41
UCECchr1943767661Missense_MutationNAH389R0.11
UCECchr1943780796Missense_MutationNAE22D0.4
UCECchr1943769785Silentrs756276998K288K0.19
UCECchr1943774329SilentNAI182I0.46
UCECchr1943776605Missense_Mutationrs199820891T64M0.07
UCECchr1943774443Missense_MutationnovelF144L0.41
UCECchr1943769382Intronnovel0.24
UCECchr1943774310Missense_MutationNAR189C0.52

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.00690.069756
KIRPDEL0.04170.11554
LAMLDEL0.01051.2971e-07
LUSCDEL0.18960.002071
MESODEL0.13790.20184
PRADAMP0.01020.16448
READDEL0.06670.23023
SKCMDEL0.11992.2081e-08
TGCTDEL0.28670.0046229
THCAAMP0.0180.075436
THCADEL0.0020.23456
UCSDEL0.19640.12448

Survival Analysis
CancerP-value Q-value
THYM0.0059

Kaplan-Meier Survival Analysis

MESO0.014

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

PRAD0.047

Kaplan-Meier Survival Analysis

LUSC0.045

Kaplan-Meier Survival Analysis

BRCA0.012

Kaplan-Meier Survival Analysis

TGCT0.023

Kaplan-Meier Survival Analysis

KIRP0.0029

Kaplan-Meier Survival Analysis

PAAD0.00061

Kaplan-Meier Survival Analysis

BLCA0.0042

Kaplan-Meier Survival Analysis

UCEC0.023

Kaplan-Meier Survival Analysis

GBM0.00011

Kaplan-Meier Survival Analysis

DLBC0.02

Kaplan-Meier Survival Analysis

LUAD0.014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000104783 (Gene tree)
Gene ID
3783
Gene Symbol
KCNN4
Alias
KCa3.1|hSK4|hKCa4|hIKCa1|IK
Full Name
potassium calcium-activated channel subfamily N member 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
15,607 bases
Position
chr19:43,766,533-43,782,139
Accession
6293
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000600909KCNN4-2071190-ENSP0000047033959 (aa)-M0QZ70
ENST00000615047KCNN4-2092029XM_005258883ENSP00000485014295 (aa)XP_005258940D1MQ08
ENST00000601549KCNN4-2081406--- (aa)--
ENST00000262888KCNN4-2012244XM_005258882ENSP00000262888427 (aa)XP_005258939O15554
ENST00000598836KCNN4-2031003-ENSP00000471900165 (aa)-M0R1J0
ENST00000648053KCNN4-2101270--- (aa)--
ENST00000599720KCNN4-205983-ENSP0000047251357 (aa)-M0R2F1
ENST00000600408KCNN4-206648-ENSP00000472510113 (aa)-M0R2E8
ENST00000648319KCNN4-2111956-ENSP00000496939427 (aa)-UPI0000000DF3
ENST00000597184KCNN4-202631--- (aa)--
ENST00000599107KCNN4-204687--- (aa)--
Gene Model
Click here to download ENSG00000104783's gene model file
Pathways
Pathway IDPathway NameSource
hsa04911Insulin secretionKEGG
hsa04970Salivary secretionKEGG
hsa04974Protein digestion and absorptionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000104783Breast Neoplasms2E-1023535729
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000104783rs563448931943778377AMonocyte count27863252[0.04-0.055] unit decrease0.04736383EFO_0005091
ENSG00000104783rs5639951943774629AMean corpuscular volume27863252[0.017-0.034] unit decrease0.02572105EFO_0004526
ENSG00000104783rs118797981943777746AGranulocyte percentage of myeloid white cells27863252[0.038-0.053] unit increase0.04540951EFO_0007997
ENSG00000104783rs5639951943774629AHemoglobin concentration27863252[0.017-0.034] unit increase0.02525654EFO_0004509
ENSG00000104783rs118797981943777746AMonocyte percentage of white cells27863252[0.04-0.054] unit decrease0.04723772EFO_0007989
ENSG00000104783rs5639951943774629AMean corpuscular hemoglobin concentration27863252[0.037-0.054] unit increase0.04561461EFO_0004528
ENSG00000104783rs6495401943774627?White blood cell count30595370EFO_0004308
ENSG00000104783rs3475191943769364?Red blood cell count30595370EFO_0004305
ENSG00000104783rs16851911943779080TBreast cancer29059683[0.046-0.071] unit decrease0.0586EFO_0000305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104783's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002376immune system process-IEAProcess
GO:0005267potassium channel activity-TASFunction
GO:0005515protein binding10880439.12198491.18796614.27092946.29724949.IPIFunction
GO:0005516calmodulin binding21873635.IBAFunction
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane26148990.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0006813potassium ion transport9380751.TASProcess
GO:0006816calcium ion transport18796614.IDAProcess
GO:0006884cell volume homeostasis-IEAProcess
GO:0006952defense response9407042.TASProcess
GO:0008076voltage-gated potassium channel complex18796614.ICComponent
GO:0015269calcium-activated potassium channel activity18796614.26148990.IDAFunction
GO:0016286small conductance calcium-activated potassium channel activity-IEAFunction
GO:0019903protein phosphatase binding18796614.IPIFunction
GO:0022894Intermediate conductance calcium-activated potassium channel activity21873635.IBAFunction
GO:0030322stabilization of membrane potential18796614.IDAProcess
GO:0031982vesicle25468996.IDAComponent
GO:0043005neuron projection21873635.IBAComponent
GO:0043025neuronal cell body21873635.IBAComponent
GO:0045332phospholipid translocation-IEAProcess
GO:0046541saliva secretion-IEAProcess
GO:0050714positive regulation of protein secretion-IEAProcess
GO:0050862positive regulation of T cell receptor signaling pathway18796614.IDAProcess
GO:0071805potassium ion transmembrane transport21873635.IBAProcess
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