EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20884074Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.Lung Cancer2011 MayKikuchi Jdoi: 10.1016/j.lungcan.2010.08.020
17222376[Expression and significance of MCM4 in esophageal cancer].Ai Zheng2007 JanHuang XP-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr847970637Missense_MutationnovelQ521E0.31
BLCAchr847962092Missense_MutationnovelY92C0.27
BLCAchr847961540Missense_MutationNAS32C0.33
BLCAchr847974804Nonsense_MutationnovelS736*0.34
BLCAchr847970003Missense_MutationnovelE460D0.74
BLCAchr847962949Missense_Mutationrs562067900N201S0.49
BLCAchr847962834Missense_MutationnovelP191H0.15
BLCAchr847962159SilentnovelQ114Q0.11
BLCAchr847975764Missense_MutationNAL805F0.18
BLCAchr847974893Missense_Mutationrs149597772R766W0.27
BLCAchr847961518Missense_MutationNAR25W0.2
BLCAchr847970799Missense_MutationnovelE575K0.32
BLCAchr847973038Missense_MutationnovelE704Q0.8
BRCAchr847970732SilentNAE552E0.49
BRCAchr847975822Nonsense_MutationNAE825*0.38
BRCAchr847974904SilentNAL769L0.17
BRCAchr847970655Missense_Mutationrs751154452V527I0.08
BRCAchr847974748Missense_MutationNAM717I0.19
BRCAchr847969847SilentNAV408V0.15
BRCAchr847963002Missense_MutationNAD219H0.21
BRCAchr847966325Missense_MutationNAE324V0.25
BRCAchr847962992SilentNAI215I0.12
BRCAchr847974912Missense_MutationNAS772C0.25
BRCAchr847970032Missense_MutationnovelI470T0.06
BRCAchr847971419Nonsense_MutationnovelK627*0.07
CESCchr847962992Missense_MutationnovelI215M0.1
CESCchr847975722SilentnovelS791S0.31
CESCchr847961561Missense_MutationnovelG39D0.38
CESCchr847962777Missense_Mutationrs369755637R172H0.36
CESCchr847966366Missense_Mutationrs760155775A338T0.37
CESCchr847967445SilentnovelL378L0.37
COADchr847962944Splice_SitenovelX200_splice0.27
COADchr847969821Nonsense_MutationNAR400*0.34
COADchr847976768Missense_MutationNAR861H0.24
COADchr847973008Missense_Mutationrs777231755A694T0.19
COADchr847962188Missense_MutationNAG124V0.32
COADchr847966381Missense_Mutationrs768182076R343C0.19
COADchr847972915Missense_MutationnovelA663S0.1
COADchr847971419Frame_Shift_DelNAT629Qfs*180.36
COADchr847969806Nonsense_MutationNAR395*0.23
COADchr847971366Missense_MutationNAA609V0.39
COADchr847961200Frame_Shift_DelnovelA21Pfs*700.14
COADchr847961640Frame_Shift_DelnovelD66Tfs*250.45
COADchr847961641Missense_MutationnovelD66H0.45
COADchr847962763Splice_SiteNAX168_splice0.1
COADchr847971419Frame_Shift_DelNAT629Qfs*180.25
COADchr847969976Missense_MutationnovelE451D0.26
COADchr847974804Nonsense_MutationnovelS736*0.41
COADchr847966338Silentrs200670710C328C0.17
DLBCchr847976772SilentnovelL862L0.18
ESCAchr847969781Splice_SitenovelX392_splice0.08
ESCAchr847969918Missense_MutationnovelL432R0.12
GBMchr847976689Missense_Mutationrs747765310I835V0.46
GBMchr847967377Nonsense_MutationnovelE356*0.09
GBMchr847967380Missense_MutationnovelS357P0.22
GBMchr847961615Missense_MutationnovelV57G0.2
GBMchr847962174SilentnovelG119G0.41
GBMchr847962175Missense_MutationnovelS120P0.39
GBMchr847971446Missense_MutationnovelL636V0.09
GBMchr847967443Missense_MutationnovelL378F0.04
GBMchr847970015SilentnovelS464S0.09
GBMchr847974893Missense_Mutationrs149597772R766W0.42
GBMchr847967425Missense_MutationnovelL372M0.05
GBMchr847974932Missense_MutationnovelG779S0.37
HNSCchr847971369Missense_MutationNAR610L0.22
HNSCchr847962189SilentnovelG124G0.26
HNSCchr847969931SilentnovelA436A0.19
HNSCchr847972944Missense_MutationNAQ672H0.31
HNSCchr847962064Missense_MutationnovelD83Y0.07
HNSCchr847974847SilentnovelS750S0.08
HNSCchr847975799Missense_MutationnovelA817V0.3
HNSCchr847961651Missense_MutationnovelF69S0.09
HNSCchr847970720Missense_MutationnovelM548I0.23
KIRCchr847961547SilentNAS34S0.39
LGGchr847970789Nonsense_MutationnovelC571*0.41
LGGchr847973029Missense_Mutationrs767399226R701W0.45
LGGchr847974759Missense_MutationnovelG721D0.41
LIHCchr847970510Splice_SitenovelX479_splice0.05
LIHCchr847961644Missense_Mutationrs755044869V67M0.45
LIHCchr847971363Missense_MutationNAN608I0.2
LUADchr847969965Missense_MutationNAL448V0.24
LUADchr847976728Missense_MutationNAA848S0.15
LUADchr847970788Missense_MutationNAC571F0.34
LUADchr8479611015'UTRnovel0.55
LUADchr847967471Missense_MutationNAR387K0.24
LUADchr847970830Nonsense_MutationnovelS585*0.4
LUADchr847970831Silentrs767159783S585S0.4
LUADchr847962077Missense_MutationNAS87I0.13
LUADchr847961563Missense_Mutationrs755169604E40K0.37
LUADchr847970817Missense_MutationNAE581K0.12
LUADchr847970574Missense_MutationnovelF500I0.06
LUADchr847970796Missense_MutationNAD574Y0.16
LUADchr847970805Missense_MutationNAD577Y0.29
LUADchr847966310Missense_MutationNAR319L0.19
LUADchr847970849Frame_Shift_DelnovelE592Nfs*550.1
LUSCchr847966214Missense_MutationnovelG287D0.26
LUSCchr847974903Missense_MutationnovelL769Q0.06
LUSCchr847975762Missense_MutationnovelL805M0.12
LUSCchr847964693Missense_MutationNAM271I0.22
LUSCchr847966327Missense_MutationNAP325A0.23
LUSCchr847970868Missense_MutationNAI598F0.3
LUSCchr847961672Missense_Mutationrs752922408H76R0.23
LUSCchr847970711Silentrs374108311A545A0.1
LUSCchr847970877Splice_SitenovelX600_splice0.26
LUSCchr847972944Missense_MutationNAQ672H0.16
LUSCchr847961531Missense_MutationnovelA29D0.2
LUSCchr847961530Missense_MutationnovelA29S0.15
LUSCchr8479768253'UTRrs3773001890.18
LUSCchr847967402Missense_MutationnovelG364E0.35
LUSCchr847962058Missense_MutationNAP81T0.39
OVchr847970054Missense_MutationnovelK477N0.26
OVchr847970607Missense_MutationNAD511N0.29
OVchr847974817Frame_Shift_InsnovelA741Lfs*80.32
OVchr847974818In_Frame_InsnovelA741delinsVLGFFVCFFET0.3
OVchr847970606Silentrs774640100G510G0.46
PRADchr847966255Missense_MutationNAE301K0.55
READchr847970804Silentrs148525401F576F0.56
READchr847969954Missense_MutationNAK444T0.15
READchr847974850Silentrs780201599N751N0.48
READchr847962065Missense_MutationnovelD83A0.09
READchr847975777Missense_MutationNAL810V0.09
SARCchr847966316Missense_MutationnovelR321H0.48
SKCMchr847971375Missense_MutationnovelS612F0.45
SKCMchr847970626Missense_MutationNAS517F0.17
SKCMchr847970627SilentNAS517S0.18
SKCMchr847974767Missense_Mutationrs201708189R724W0.4
SKCMchr847962976Missense_MutationnovelV210A0.33
SKCMchr847971366Missense_MutationNAA609V0.16
SKCMchr847961543Missense_Mutationrs755898364P33L0.45
SKCMchr847961544Silentrs199890906P33P0.45
SKCMchr847970703Missense_MutationNAL543F0.46
SKCMchr847970626Missense_MutationNAS517F0.48
SKCMchr847966267Nonsense_MutationNAQ305*0.22
SKCMchr847961606Missense_MutationNAS54L0.16
SKCMchr847974826SilentnovelA743A0.12
SKCMchr847974827Missense_MutationnovelH744Y0.12
SKCMchr847970689Missense_MutationNAS538F0.11
SKCMchr847970660SilentNAP528P0.44
SKCMchr847973027Missense_MutationNAP700L0.17
SKCMchr847966357Missense_MutationnovelH335Y0.29
STADchr847969895Silentrs376248536T424T0.16
STADchr847966338Silentrs200670710C328C0.29
STADchr847971419Frame_Shift_DelNAT629Qfs*180.25
STADchr847974893Missense_Mutationrs149597772R766W0.09
STADchr847966283Missense_MutationNAA310V0.18
STADchr847966338Silentrs200670710C328C0.16
STADchr847975831Missense_Mutationrs757711165R828W0.17
STADchr847974938Missense_Mutationrs765226208V781M0.16
STADchr847973027Missense_MutationNAP700L0.33
STADchr847970594SilentnovelI506I0.24
STADchr847976767Missense_Mutationrs375720200R861C0.34
STADchr847971419Frame_Shift_DelNAT629Qfs*180.26
STADchr847962304Splice_SiteNAX134_splice0.09
STADchr847975738Missense_Mutationrs749728850R797W0.26
STADchr847976754SilentNAT856T0.17
STADchr847974960Missense_Mutationrs781271560T788M0.44
STADchr847971418Frame_Shift_InsnovelT629Nfs*40.21
STADchr847970876Splice_RegionNAK600K0.13
STADchr847976764Missense_Mutationrs142208176V860M0.22
THCAchr847971363Missense_MutationNAN608I0.23
THCAchr847962852Frame_Shift_InsnovelG198Kfs*190.04
UCECchr847966246Missense_MutationNAE298K0.37
UCECchr847970804Silentrs148525401F576F0.35
UCECchr847970533Missense_MutationNAG486D0.28
UCECchr847975765Missense_Mutationrs775169389K806E0.36
UCECchr8479769283'UTRnovel0.31
UCECchr847970654Silentrs34157149L526L0.16
UCECchr847969880SilentnovelI419I0.53
UCECchr847970023Missense_MutationnovelA467D0.15
UCECchr847970577Missense_Mutationrs773264700R501W0.42
UCECchr847972982Missense_Mutationrs763060839A685V0.4
UCECchr8479768593'UTRnovel0.71
UCECchr847962763Splice_SiteNAX168_splice0.39
UCECchr847975816Missense_MutationnovelL823F0.3
UCECchr847972931Missense_MutationNAA668V0.18
UCECchr8479767903'UTRnovel0.29
UCECchr847969919SilentNAL432L0.43
UCECchr847969806Nonsense_MutationNAR395*0.25
UCECchr847974845Missense_Mutationrs745883715S750A0.17
UCECchr847962802Missense_MutationnovelE180D0.27
UCECchr847964695Missense_MutationNAR272K0.67
UCECchr8479768513'UTRnovel0.06
UCECchr847976716SilentNAL844L0.05
UCECchr847962776Missense_Mutationrs771112920R172C0.37
UCECchr847975831Missense_Mutationrs757711165R828W0.25
UCECchr847976723Missense_Mutationrs566436447A846V0.71
UCECchr847961675Missense_MutationnovelS77Y0.4
UCECchr847971419Frame_Shift_DelNAT629Qfs*180.32
UCECchr847961573Missense_MutationNAT43N0.38
UCECchr8479768593'UTRnovel0.09
UCECchr847962213SilentnovelD132D0.25
UCECchr847966246Missense_MutationNAE298K0.44
UCECchr847971419Frame_Shift_DelNAT629Qfs*180.28
UCECchr847962052Splice_SitenovelX79_splice0.27
UCECchr847964612SilentnovelI244I0.36
UCECchr847966339Missense_Mutationrs768674866G329R0.32
UCECchr8479768253'UTRrs3773001890.11
UCECchr847970577Missense_Mutationrs773264700R501W0.46
UCECchr847970804Silentrs148525401F576F0.27
UCECchr847961560Missense_MutationnovelG39C0.11
UCECchr847962110Missense_MutationNAR98Q0.43
UCECchr847966328Missense_MutationNAP325R0.36
UCECchr847971366Missense_MutationNAA609V0.23
UCECchr847972893Silentrs758743457D655D0.13
UCECchr847964597Missense_MutationnovelM239I0.38
UCECchr847969865SilentNAT414T0.17
UCECchr847974917Missense_MutationnovelT774A0.43
UCECchr847966342Missense_Mutationrs144766420R330C0.36
UCSchr847961204SilentnovelP20P1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
READDEL0.07270.20625
UCSAMP0.60714.2724e-06

Survival Analysis
CancerP-value Q-value
THYM0.006

Kaplan-Meier Survival Analysis

KIRC0.026

Kaplan-Meier Survival Analysis

SARC0.00051

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

SKCM0.012

Kaplan-Meier Survival Analysis

LUSC0.011

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.009

Kaplan-Meier Survival Analysis

PAAD0.00033

Kaplan-Meier Survival Analysis

CESC0.0031

Kaplan-Meier Survival Analysis

READ0.029

Kaplan-Meier Survival Analysis

KICH0.0011

Kaplan-Meier Survival Analysis

UCEC0.00018

Kaplan-Meier Survival Analysis

LIHC0.00015

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.01

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

UVM0.00026

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000104738 (Gene tree)
Gene ID
4173
Gene Symbol
MCM4
Alias
CDC54|hCdc21|P1-Cdc21|MGC33310|CDC21
Full Name
minichromosome maintenance complex component 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
17,976 bases
Position
chr8:47,960,185-47,978,160
Accession
6947
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000520994MCM4-210522--- (aa)--
ENST00000521261MCM4-2121342--- (aa)--
ENST00000519138MCM4-206927--- (aa)--
ENST00000648554MCM4-220755-ENSP00000496985191 (aa)--
ENST00000521151MCM4-2111125--- (aa)--
ENST00000519170MCM4-207734--- (aa)--
ENST00000523944MCM4-2144105-ENSP00000430194863 (aa)-P33991
ENST00000517709MCM4-202842--- (aa)--
ENST00000524086MCM4-215547-ENSP0000042782981 (aa)-E5RG53
ENST00000648407MCM4-2172598-ENSP00000497881742 (aa)--
ENST00000262105MCM4-2014183-ENSP00000262105863 (aa)-P33991
ENST00000519470MCM4-208498--- (aa)--
ENST00000518221MCM4-203572-ENSP00000430329140 (aa)-E5RFR3
ENST00000649919MCM4-2222957-ENSP00000498202813 (aa)-UPI000387DE53
ENST00000520637MCM4-2091981-ENSP00000427875582 (aa)-E5RG31
ENST00000649838MCM4-2213157-ENSP00000497648904 (aa)--
ENST00000649973MCM4-2234062-ENSP00000496964863 (aa)-UPI000013D25C
ENST00000518382MCM4-204366-ENSP0000043086427 (aa)-E5RHP5
ENST00000650327MCM4-225235--- (aa)--
ENST00000650216MCM4-2242399-ENSP00000497093749 (aa)--
ENST00000647877MCM4-2161256-ENSP00000497251107 (aa)--
ENST00000523853MCM4-213354--- (aa)--
ENST00000648519MCM4-2183226-ENSP00000497176160 (aa)--
ENST00000648533MCM4-219733--- (aa)--
ENST00000518680MCM4-205862--- (aa)--
Gene Model
Click here to download ENSG00000104738's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa04110Cell cycleKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000104738rs762679847972876ARed blood cell count27863252[0.022-0.042] unit decrease0.03194922EFO_0004305
ENSG00000104738rs762679847972876AMean corpuscular volume27863252[0.025-0.044] unit increase0.03467907EFO_0004526
ENSG00000104738rs762679847972876?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000104738rs762679847972876?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104738's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000104738MCM49968.220FBgn0015929dpa9961.469Drosophila_melanogaster
ENSG00000104738MCM49047.701FBgn0014861Mcm26733.651Drosophila_melanogaster
ENSG00000104738MCM48950.000ENSG00000073111MCM28340.556Homo_sapiens
ENSG00000104738MCM48666.667YPR019WMCM48047.397Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0003697single-stranded DNA binding-IEAFunction
GO:0004003ATP-dependent DNA helicase activity9305914.IDAFunction
GO:0005515protein binding12364596.15232106.16902406.17296731.22190034.22540012.23764002.24299456.24407287.25036637.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus8265339.NASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006260DNA replication9465298.NASProcess
GO:0006260DNA replication-TASProcess
GO:0006268DNA unwinding involved in DNA replication-IEAProcess
GO:0006270DNA replication initiation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0042555MCM complex17296731.IDAComponent
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