EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	729179	3'UTR	novel		0.25
BLCA	chr16	727536	Silent	novel	L9L	0.29
BRCA	chr16	727584	Silent	novel	A25A	0.29
BRCA	chr16	727579	Missense_Mutation	novel	E24Q	0.17
CESC	chr16	729229	3'UTR	novel		0.71
CESC	chr16	727397	Intron	novel		0.22
CESC	chr16	727405	Splice_Region	novel		0.45
CHOL	chr16	727405	Splice_Region	novel		0.21
COAD	chr16	729034	Silent	novel	L247L	0.32
COAD	chr16	727597	Missense_Mutation	NA	V30M	0.43
COAD	chr16	727598	Missense_Mutation	NA	V30G	0.42
COAD	chr16	727464	5'UTR	NA		0.12
COAD	chr16	727462	5'UTR	rs374747544		0.3
COAD	chr16	728928	Frame_Shift_Del	rs756119987	*E214Rfs15**	0.33
COAD	chr16	729053	Missense_Mutation	novel	A253V	0.38
COAD	chr16	728928	Frame_Shift_Del	rs756119987	*E214Rfs15**	0.94
COAD	chr16	728875	Missense_Mutation	NA	A194S	0.21
ESCA	chr16	729072	Silent	rs199808048	T259T	0.14
GBM	chr16	729081	Silent	rs774730542	C262C	0.26
HNSC	chr16	729229	3'UTR	novel		0.15
KIRP	chr16	728934	Silent	NA	G213G	0.85
LIHC	chr16	727559	Missense_Mutation	NA	V17G	0.21
LIHC	chr16	727615	Splice_Site	novel	X35_splice	0.29
LIHC	chr16	727498	5'UTR	novel		0.21
LIHC	chr16	728845	Missense_Mutation	novel	K184E	0.38
LUAD	chr16	727537	Missense_Mutation	novel	E10Q	0.37
LUAD	chr16	727579	Missense_Mutation	novel	E24Q	0.31
LUAD	chr16	727579	Missense_Mutation	novel	E24K	0.19
LUSC	chr16	728914	Missense_Mutation	novel	R207S	0.5
LUSC	chr16	729062	Missense_Mutation	NA	A256D	0.38
LUSC	chr16	727524	Silent	NA	V5V	0.23
OV	chr16	728950	Missense_Mutation	novel	G219R	0.23
SARC	chr16	728853	Missense_Mutation	novel	E186D	0.18
STAD	chr16	727579	Missense_Mutation	novel	E24Q	0.72
STAD	chr16	729157	Missense_Mutation	NA	V288M	0.49
TGCT	chr16	727355	Intron	novel		0.07
UCEC	chr16	729023	Missense_Mutation	rs367594110	M243T	0.17
UCEC	chr16	729230	3'UTR	novel		0.27
UCEC	chr16	727464	5'UTR	NA		0.39
UCEC	chr16	727390	Intron	novel		0.36
UCEC	chr16	727544	Missense_Mutation	novel	N12S	0.36
UCEC	chr16	728886	Silent	novel	S197S	0.5
UCEC	chr16	727456	5'UTR	novel		0.2
UCEC	chr16	729160	Silent	novel	L289L	0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5333	0.22898
CHOL	DEL	0.1111	0.23475
ESCA	DEL	0.288	0.012791
LUAD	DEL	0.1298	0.1886
UCS	DEL	0.5179	0.13407

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0006	Kaplan-Meier Survival Analysis
STAD	0.046	Kaplan-Meier Survival Analysis
MESO	0.035	Kaplan-Meier Survival Analysis
ACC	0.027	Kaplan-Meier Survival Analysis
UCS	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0029	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
COAD	0.028	Kaplan-Meier Survival Analysis
PCPG	0.039	Kaplan-Meier Survival Analysis
KICH	0.014	Kaplan-Meier Survival Analysis
LIHC	0.0092	Kaplan-Meier Survival Analysis
LGG	0.044	Kaplan-Meier Survival Analysis
UVM	0.0017	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000103253 (Gene tree)
Gene ID: 84264
Gene Symbol: HAGHL
Alias: MGC2605
Full Name: hydroxyacylglutathione hydrolase like
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 8,590 bases
Position: chr16:726,936-735,525
Accession: 14177
Summary: HAGHL (Hydroxyacylglutathione Hydrolase Like) is a Protein Coding gene. Diseases associated with HAGHL include Myopathy, Centronuclear, 4. Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydroxyacylglutathione hydrolase activity. An important paralog of this gene is HAGH.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000456978	Lactamase_B	PF00753.27	1.7e-10	1	1
ENSP00000456390	Lactamase_B	PF00753.27	2.8e-10	1	1
ENSP00000341952	Lactamase_B	PF00753.27	4.6e-10	1	1
ENSP00000374353	Lactamase_B	PF00753.27	5.2e-10	1	1
ENSP00000460451	Lactamase_B	PF00753.27	6.6e-10	1	1
ENSP00000456104	Lactamase_B	PF00753.27	7e-06	1	1
ENSP00000455616	Lactamase_B	PF00753.27	1.4e-05	1	1
ENSP00000447170	Lactamase_B	PF00753.27	2.3e-05	1	1
ENSP00000457219	Lactamase_B	PF00753.27	2.3e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000567696	HAGHL-215	2199	-	-	- (aa)	-	-
ENST00000549114	HAGHL-204	1820	-	ENSP00000447170	202 (aa)	-	Q6PII5
ENST00000561546	HAGHL-205	1041	XM_017023774	ENSP00000456390	227 (aa)	XP_016879263	B4DED4
ENST00000569143	HAGHL-217	564	-	-	- (aa)	-	-
ENST00000561750	HAGHL-207	675	-	-	- (aa)	-	-
ENST00000568141	HAGHL-216	740	-	ENSP00000455616	192 (aa)	-	H3BQ57
ENST00000563156	HAGHL-210	572	-	-	- (aa)	-	-
ENST00000647875	HAGHL-220	2481	-	-	- (aa)	-	-
ENST00000567414	HAGHL-214	735	-	ENSP00000460451	172 (aa)	-	I3L3H5
ENST00000564545	HAGHL-213	663	-	ENSP00000454712	84 (aa)	-	H3BN70
ENST00000569604	HAGHL-219	2162	-	-	- (aa)	-	-
ENST00000569385	HAGHL-218	440	-	ENSP00000458711	21 (aa)	-	I3L1B7
ENST00000564537	HAGHL-212	1667	-	ENSP00000457219	202 (aa)	-	Q6PII5
ENST00000562187	HAGHL-209	100	-	ENSP00000459148	13 (aa)	-	I3L1W0
ENST00000389703	HAGHL-203	1347	XM_005255632	ENSP00000374353	282 (aa)	XP_005255689	Q6PII5
ENST00000341413	HAGHL-201	1701	XM_005255631	ENSP00000341952	290 (aa)	XP_005255688	Q6PII5
ENST00000389701	HAGHL-202	1295	-	-	- (aa)	-	-
ENST00000562141	HAGHL-208	650	-	ENSP00000456978	200 (aa)	-	H3BT20
ENST00000563792	HAGHL-211	493	-	ENSP00000456104	108 (aa)	-	H3BR74
ENST00000561561	HAGHL-206	434	-	ENSP00000457486	94 (aa)	-	H3BU61

Gene Model

Click here to download ENSG00000103253's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103253's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103253	HAGHL	100	64.035	ENSAPOG00000012964	HAGHL	99	61.733	Acanthochromis_polyacanthus
ENSG00000103253	HAGHL	100	63.596	ENSACIG00000021985	HAGHL	99	61.372	Amphilophus_citrinellus
ENSG00000103253	HAGHL	100	64.035	ENSAOCG00000008273	HAGHL	99	61.733	Amphiprion_ocellaris
ENSG00000103253	HAGHL	100	64.035	ENSAPEG00000010628	HAGHL	99	61.733	Amphiprion_percula
ENSG00000103253	HAGHL	100	64.474	ENSATEG00000024521	HAGHL	97	62.094	Anabas_testudineus
ENSG00000103253	HAGHL	83	76.667	ENSAPLG00000016275	-	100	74.257	Anas_platyrhynchos
ENSG00000103253	HAGHL	100	98.238	ENSANAG00000028712	HAGHL	99	97.509	Aotus_nancymaae
ENSG00000103253	HAGHL	100	64.912	ENSAMXG00000038108	HAGHL	99	62.455	Astyanax_mexicanus
ENSG00000103253	HAGHL	100	90.050	ENSBTAG00000002481	HAGHL	99	87.814	Bos_taurus
ENSG00000103253	HAGHL	100	98.678	ENSCJAG00000012174	HAGHL	99	97.509	Callithrix_jacchus
ENSG00000103253	HAGHL	100	89.055	ENSCAFG00000019606	HAGHL	98	88.448	Canis_familiaris
ENSG00000103253	HAGHL	100	89.055	ENSCAFG00020008946	HAGHL	98	88.448	Canis_lupus_dingo
ENSG00000103253	HAGHL	100	90.547	ENSCHIG00000013374	HAGHL	98	88.489	Capra_hircus
ENSG00000103253	HAGHL	100	86.842	ENSCAPG00000017208	HAGHL	100	86.842	Cavia_aperea
ENSG00000103253	HAGHL	100	86.842	ENSCPOG00000031749	HAGHL	100	86.842	Cavia_porcellus
ENSG00000103253	HAGHL	100	98.678	ENSCCAG00000018173	HAGHL	99	98.577	Cebus_capucinus
ENSG00000103253	HAGHL	100	98.678	ENSCATG00000031620	HAGHL	100	97.872	Cercocebus_atys
ENSG00000103253	HAGHL	100	98.678	ENSCSAG00000012211	HAGHL	100	97.872	Chlorocebus_sabaeus
ENSG00000103253	HAGHL	100	67.662	ENSCPBG00000021125	HAGHL	79	67.662	Chrysemys_picta_bellii
ENSG00000103253	HAGHL	100	87.065	ENSCGRG00001000478	Haghl	98	86.842	Cricetulus_griseus_chok1gshd
ENSG00000103253	HAGHL	100	87.065	ENSCGRG00000018412	Haghl	98	85.043	Cricetulus_griseus_crigri
ENSG00000103253	HAGHL	100	61.842	ENSCSEG00000015768	HAGHL	99	59.567	Cynoglossus_semilaevis
ENSG00000103253	HAGHL	100	61.842	ENSCVAG00000002773	HAGHL	96	59.286	Cyprinodon_variegatus
ENSG00000103253	HAGHL	100	92.105	ENSEASG00005018399	HAGHL	97	90.217	Equus_asinus_asinus
ENSG00000103253	HAGHL	100	92.105	ENSECAG00000006582	HAGHL	92	89.928	Equus_caballus
ENSG00000103253	HAGHL	100	90.789	ENSFCAG00000030617	HAGHL	98	89.493	Felis_catus
ENSG00000103253	HAGHL	100	71.491	ENSGALG00000021040	HAGHL	98	66.547	Gallus_gallus
ENSG00000103253	HAGHL	100	60.965	ENSGAFG00000020194	HAGHL	96	58.571	Gambusia_affinis
ENSG00000103253	HAGHL	100	68.860	ENSGAGG00000004197	HAGHL	98	66.065	Gopherus_agassizii
ENSG00000103253	HAGHL	100	97.357	ENSGGOG00000013934	HAGHL	100	97.163	Gorilla_gorilla
ENSG00000103253	HAGHL	100	66.667	ENSIPUG00000005298	haghl	98	63.177	Ictalurus_punctatus
ENSG00000103253	HAGHL	100	86.842	ENSSTOG00000004187	HAGHL	99	84.532	Ictidomys_tridecemlineatus
ENSG00000103253	HAGHL	100	61.404	ENSKMAG00000019946	HAGHL	99	58.845	Kryptolebias_marmoratus
ENSG00000103253	HAGHL	100	65.351	ENSLBEG00000026426	HAGHL	99	62.816	Labrus_bergylta
ENSG00000103253	HAGHL	100	99.119	ENSMFAG00000032740	HAGHL	100	98.227	Macaca_fascicularis
ENSG00000103253	HAGHL	100	99.119	ENSMMUG00000006453	HAGHL	100	98.227	Macaca_mulatta
ENSG00000103253	HAGHL	100	99.119	ENSMNEG00000045127	HAGHL	100	98.227	Macaca_nemestrina
ENSG00000103253	HAGHL	100	63.596	ENSMAMG00000023474	HAGHL	79	61.011	Mastacembelus_armatus
ENSG00000103253	HAGHL	100	92.982	ENSMICG00000010673	HAGHL	99	92.199	Microcebus_murinus
ENSG00000103253	HAGHL	100	86.567	ENSMOCG00000011485	Haghl	99	83.871	Microtus_ochrogaster
ENSG00000103253	HAGHL	100	64.912	ENSMMOG00000007607	HAGHL	99	62.816	Mola_mola
ENSG00000103253	HAGHL	100	75.000	ENSMODG00000016793	HAGHL	98	70.609	Monodelphis_domestica
ENSG00000103253	HAGHL	100	64.474	ENSMALG00000007263	HAGHL	99	61.372	Monopterus_albus
ENSG00000103253	HAGHL	100	84.577	MGP_CAROLIEiJ_G0021248	Haghl	100	82.301	Mus_caroli
ENSG00000103253	HAGHL	100	85.572	ENSMUSG00000061046	Haghl	100	83.186	Mus_musculus
ENSG00000103253	HAGHL	100	85.572	MGP_PahariEiJ_G0023566	Haghl	100	84.956	Mus_pahari
ENSG00000103253	HAGHL	100	84.577	MGP_SPRETEiJ_G0022159	Haghl	100	83.186	Mus_spretus
ENSG00000103253	HAGHL	100	88.596	ENSMPUG00000015917	HAGHL	98	88.087	Mustela_putorius_furo
ENSG00000103253	HAGHL	100	88.158	ENSNGAG00000015503	Haghl	99	84.946	Nannospalax_galili
ENSG00000103253	HAGHL	100	64.912	ENSNBRG00000002812	HAGHL	99	62.455	Neolamprologus_brichardi
ENSG00000103253	HAGHL	100	84.043	ENSNLEG00000008276	HAGHL	100	84.043	Nomascus_leucogenys
ENSG00000103253	HAGHL	97	74.251	ENSMEUG00000002798	HAGHL	86	68.812	Notamacropus_eugenii
ENSG00000103253	HAGHL	100	81.116	ENSODEG00000015274	HAGHL	100	81.974	Octodon_degus
ENSG00000103253	HAGHL	100	62.281	ENSORLG00000026668	HAGHL	98	60.650	Oryzias_latipes
ENSG00000103253	HAGHL	100	62.281	ENSORLG00020017922	HAGHL	98	61.151	Oryzias_latipes_hni
ENSG00000103253	HAGHL	100	62.719	ENSORLG00015000203	HAGHL	98	61.733	Oryzias_latipes_hsok
ENSG00000103253	HAGHL	100	63.158	ENSOMEG00000012242	HAGHL	98	62.094	Oryzias_melastigma
ENSG00000103253	HAGHL	100	91.045	ENSOARG00000013741	HAGHL	98	88.849	Ovis_aries
ENSG00000103253	HAGHL	100	90.789	ENSPPRG00000010708	HAGHL	98	89.493	Panthera_pardus
ENSG00000103253	HAGHL	100	100.000	ENSPTRG00000007560	HAGHL	100	99.645	Pan_troglodytes
ENSG00000103253	HAGHL	100	98.238	ENSPANG00000004810	HAGHL	100	97.518	Papio_anubis
ENSG00000103253	HAGHL	100	66.228	ENSPKIG00000025653	HAGHL	98	64.769	Paramormyrops_kingsleyae
ENSG00000103253	HAGHL	100	68.860	ENSPSIG00000013687	HAGHL	98	65.343	Pelodiscus_sinensis
ENSG00000103253	HAGHL	100	60.870	ENSPMGG00000020542	HAGHL	89	58.781	Periophthalmus_magnuspinnatus
ENSG00000103253	HAGHL	100	88.557	ENSPEMG00000006749	Haghl	98	86.325	Peromyscus_maniculatus_bairdii
ENSG00000103253	HAGHL	100	73.684	ENSPCIG00000021189	HAGHL	98	68.817	Phascolarctos_cinereus
ENSG00000103253	HAGHL	100	61.404	ENSPFOG00000009214	HAGHL	97	58.719	Poecilia_formosa
ENSG00000103253	HAGHL	100	61.404	ENSPLAG00000014469	HAGHL	96	58.929	Poecilia_latipinna
ENSG00000103253	HAGHL	100	61.842	ENSPMEG00000019800	HAGHL	96	59.286	Poecilia_mexicana
ENSG00000103253	HAGHL	100	61.404	ENSPREG00000005837	HAGHL	96	58.929	Poecilia_reticulata
ENSG00000103253	HAGHL	100	99.559	ENSPPYG00000006929	HAGHL	100	99.291	Pongo_abelii
ENSG00000103253	HAGHL	100	91.667	ENSPCOG00000021619	HAGHL	99	89.362	Propithecus_coquereli
ENSG00000103253	HAGHL	100	66.228	ENSPNAG00000025703	HAGHL	99	63.177	Pygocentrus_nattereri
ENSG00000103253	HAGHL	100	87.065	ENSRNOG00000019612	Haghl	99	83.929	Rattus_norvegicus
ENSG00000103253	HAGHL	100	98.678	ENSRBIG00000017474	HAGHL	100	97.518	Rhinopithecus_bieti
ENSG00000103253	HAGHL	100	98.678	ENSRROG00000034220	HAGHL	100	97.872	Rhinopithecus_roxellana
ENSG00000103253	HAGHL	100	99.119	ENSSBOG00000029593	HAGHL	99	98.932	Saimiri_boliviensis_boliviensis
ENSG00000103253	HAGHL	100	73.246	ENSSHAG00000011748	HAGHL	98	68.459	Sarcophilus_harrisii
ENSG00000103253	HAGHL	100	65.789	ENSSFOG00015023471	HAGHL	98	63.571	Scleropages_formosus
ENSG00000103253	HAGHL	100	64.474	ENSSDUG00000008417	HAGHL	99	62.094	Seriola_dumerili
ENSG00000103253	HAGHL	100	64.474	ENSSLDG00000023602	HAGHL	99	61.733	Seriola_lalandi_dorsalis
ENSG00000103253	HAGHL	100	64.474	ENSSPAG00000010356	HAGHL	99	62.094	Stegastes_partitus
ENSG00000103253	HAGHL	100	89.474	ENSSSCG00000008003	HAGHL	99	87.143	Sus_scrofa
ENSG00000103253	HAGHL	100	64.912	ENSTRUG00000024857	HAGHL	96	62.590	Takifugu_rubripes
ENSG00000103253	HAGHL	100	89.552	ENSTTRG00000004095	HAGHL	99	81.443	Tursiops_truncatus
ENSG00000103253	HAGHL	100	90.050	ENSUAMG00000012731	HAGHL	98	89.170	Ursus_americanus
ENSG00000103253	HAGHL	100	89.055	ENSVVUG00000012413	HAGHL	98	88.448	Vulpes_vulpes
ENSG00000103253	HAGHL	99	64.758	ENSXETG00000007200	haghl	98	59.582	Xenopus_tropicalis
ENSG00000103253	HAGHL	100	60.965	ENSXCOG00000010304	HAGHL	96	58.214	Xiphophorus_couchianus
ENSG00000103253	HAGHL	100	60.965	ENSXMAG00000015029	HAGHL	96	58.571	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0016787	hydrolase activity	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.