EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14503807	CTCF gene mutations in invasive ductal breast cancer.	Breast Cancer Res Treat	2003 Aug	Aulmann S	-
23553099	The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells.	Int J Cancer	2013 Oct 1	Tiffen JC	doi: 10.1002/ijc.28184
11782357	Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.	Cancer Res	2002 Jan 1	Filippova GN	-
24130125	High frequency strand slippage mutations in CTCF in MSI-positive endometrial cancers.	Hum Mutat	2014 Jan	Zighelboim I	-
26784546	TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.	J Clin Invest	2016 Feb	Chen J	doi: 10.1172/JCI80937
24794443	CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.	Cell Rep	2014 May 22	Kemp CJ	doi: 10.1016/j.celrep.2014.04.004
19737964	Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation.	Clin Cancer Res	2009 Sep 15	Docquier F	doi: 10.1158/1078-0432.CCR-09-0329
19450526	Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.	Mol Cell	2009 May 15	Witcher M	doi: 10.1016/j.molcel.2009.04.001.
27490693	Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types.	PLoS Genet	2016 Aug 4	Kaiser VB	doi: 10.1371/journal.pgen.1006207
16140944	Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.	Cancer Res	2005 Sep 1	Hong JA	-
15958555	Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis.	Cancer Res	2005 Jun 15	Docquier F	-
19513555	Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia.	Int J Oncol	2009 Jul	Paradowska A	-
26478432	CTCF negatively regulates HOXA10 expression in breast cancer cells.	Biochem Biophys Res Commun	2015 Nov 27	Mustafa M	doi: 10.1016/j.bbrc.2015.10.058
24174344	CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: identification of a novel enhancer region involved in the regulation of TERT gene.	Int J Cancer	2014 May 15	Eldholm V	doi: 10.1002/ijc.28570
23908591	A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells.	Neoplasia	2013 Aug	M??ndez-Catal?? CF	-
24842653	The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer.	DNA Cell Biol	2014 Sep	Wang D	doi: 10.1089/dna.2013.2257
26330387	Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.	J Natl Cancer Inst	2015 Sep 1	Walker CJ	doi: 10.1093/jnci/djv249
26747525	IL-10 and integrin signaling pathways are associated with head and neck cancer progression.	BMC Genomics	2016 Jan 8	Bornstein S	doi: 10.1186/s12864-015-2359-6.
25592173	Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population.	Sci Rep	2015 Jan 16	Dai J	doi: 10.1038/srep07833.
25499215	Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.	Neoplasia	2014 Dec	Damaschke NA	doi: 10.1016/j.neo.2014.10.003.
26549033	DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment.	Oncogene	2016 Jul 28	Yan H	doi: 10.1038/onc.2015.423
28319062	CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.	Oncogene	2017 Jul 20	Marshall AD	doi: 10.1038/onc.2017.25
27974201	Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.	Cell Rep	2016 Dec 13	Poulos RC	doi: 10.1016/j.celrep.2016.11.055.
27762310	Chromatin accessibility contributes to simultaneous mutations of cancer genes.	Sci Rep	2016 Oct 20	Shi Y	doi: 10.1038/srep35270.
29956775	Identification of open chromosomal regions and key genes in prostate cancer via integrated analysis of DNaseseq and RNAseq data.	Mol Med Rep	2018 Aug	Wei X	doi: 10.3892/mmr.2018.9193
30086769	CTCF maintains regulatory homeostasis of cancer pathways.	Genome Biol	2018 Aug 7	Aitken SJ	doi: 10.1186/s13059-018-1484-3.
30296942	CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops.	Genome Biol	2018 Oct 8	Guo Y	doi: 10.1186/s13059-018-1531-0.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	67620736	Nonsense_Mutation	novel	E376*	0.48
BLCA	chr16	67620678	Splice_Site	novel	X363_splice	0.06
BLCA	chr16	67616843	Missense_Mutation	NA	F351L	0.18
BLCA	chr16	67620734	Missense_Mutation	novel	G375A	0.36
BLCA	chr16	67611309	Silent	novel	P159P	0.16
BLCA	chr16	67636743	Nonsense_Mutation	NA	E631*	0.4
BLCA	chr16	67628453	Silent	NA	Q534Q	0.25
BLCA	chr16	67611181	Nonsense_Mutation	NA	Q117*	0.34
BLCA	chr16	67637747	Nonsense_Mutation	NA	E687*	0.1
BLCA	chr16	67616853	Missense_Mutation	NA	S354F	0.46
BLCA	chr16	67616829	Missense_Mutation	novel	T346N	0.22
BLCA	chr16	67611142	Nonsense_Mutation	novel	E104*	0.45
BLCA	chr16	67611265	Missense_Mutation	novel	E145Q	0.5
BLCA	chr16	67611961	Missense_Mutation	novel	K264N	0.53
BLCA	chr16	67620773	Missense_Mutation	NA	S388N	0.29
BLCA	chr16	67616756	Missense_Mutation	novel	H322Y	0.36
BLCA	chr16	67636805	Silent	novel	R651R	0.08
BLCA	chr16	67616853	Missense_Mutation	novel	S354Y	0.15
BLCA	chr16	67628444	Silent	NA	T531T	0.23
BLCA	chr16	67612037	Missense_Mutation	novel	D290N	0.21
BRCA	chr16	67612020	Missense_Mutation	NA	H284P	0.24
BRCA	chr16	67611604	Missense_Mutation	NA	K258E	0.42
BRCA	chr16	67611515	Missense_Mutation	NA	F228S	0.4
BRCA	chr16	67611195	Silent	NA	P121P	0.1
BRCA	chr16	67611405	Nonsense_Mutation	NA	W191*	0.36
BRCA	chr16	67628540	Silent	NA	T563T	0.49
BRCA	chr16	67612016	Missense_Mutation	NA	R283C	0.38
BRCA	chr16	67611615	Splice_Site	NA	X261_splice	0.7
BRCA	chr16	67612019	Missense_Mutation	NA	H284Y	0.68
BRCA	chr16	67620742	Missense_Mutation	NA	P378A	0.73
BRCA	chr16	67637747	Missense_Mutation	novel	E687K	0.13
BRCA	chr16	67610934	Silent	NA	E34E	0.2
BRCA	chr16	67612019	Missense_Mutation	NA	H284N	0.57
BRCA	chr16	67611509	Missense_Mutation	NA	Y226C	0.26
BRCA	chr16	67610995	Frame_Shift_Del	novel	*N55Tfs7**	0.59
BRCA	chr16	67621528	Nonsense_Mutation	NA	E432*	0.31
BRCA	chr16	67610893	Nonsense_Mutation	NA	E21*	0.86
BRCA	chr16	67611950	Splice_Region	novel	G261delinsVR	0.71
BRCA	chr16	67637959	3'UTR	novel		0.32
BRCA	chr16	67612031	Missense_Mutation	NA	H288D	0.43
BRCA	chr16	67611610	Splice_Site	novel	X260_splice	0.73
BRCA	chr16	67610914	Frame_Shift_Del	novel	*R28Pfs17**	0.7
CESC	chr16	67637994	3'UTR	novel		0.28
CESC	chr16	67626711	Missense_Mutation	NA	R505T	0.2
CESC	chr16	67612059	Missense_Mutation	novel	H297L	0.54
CESC	chr16	67636743	Nonsense_Mutation	NA	E631*	0.3
CESC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.3
CESC	chr16	67637838	Missense_Mutation	novel	T717M	0.57
CESC	chr16	67638930	3'UTR	novel		0.53
CESC	chr16	67638239	3'UTR	novel		0.29
CESC	chr16	67628510	Silent	rs749116676	A553A	0.5
CESC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.28
CESC	chr16	67612005	Missense_Mutation	NA	S279L	0.42
CESC	chr16	67638687	3'UTR	novel		0.55
CESC	chr16	67629525	Missense_Mutation	NA	S610F	0.48
CHOL	chr16	67616753	Frame_Shift_Ins	novel	*H322Lfs12**	0.31
CHOL	chr16	67610974	Missense_Mutation	novel	G48C	0.05
COAD	chr16	67616826	Missense_Mutation	NA	H345R	0.39
COAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.1
COAD	chr16	67611184	In_Frame_Del	novel	P121_V126del	0.04
COAD	chr16	67628421	Missense_Mutation	rs767996920	A524T	0.3
COAD	chr16	67610917	Missense_Mutation	rs771567232	R29W	0.43
COAD	chr16	67620739	Missense_Mutation	NA	R377C	0.43
COAD	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.12
COAD	chr16	67611372	Frame_Shift_Ins	NA	*E182Gfs9**	0.36
COAD	chr16	67626677	Missense_Mutation	NA	R494C	0.25
COAD	chr16	67612001	Missense_Mutation	novel	R278C	0.24
COAD	chr16	67637752	Frame_Shift_Del	NA	*E691Sfs30**	0.45
COAD	chr16	67637952	3'UTR	novel		0.16
COAD	chr16	67628406	Missense_Mutation	NA	G519R	0.18
COAD	chr16	67620712	Missense_Mutation	NA	R368C	0.59
COAD	chr16	67611610	Nonsense_Mutation	novel	K260*	0.3
COAD	chr16	67611016	Frame_Shift_Del	novel	*M62Gfs10**	0.12
COAD	chr16	67626704	Missense_Mutation	NA	A503S	0.29
COAD	chr16	67629503	Missense_Mutation	rs775874494	R603C	0.24
COAD	chr16	67626587	Missense_Mutation	NA	E464K	0.29
COAD	chr16	67611406	Frame_Shift_Ins	NA	*D194Rfs36**	0.38
COAD	chr16	67628420	Silent	rs761420338	Y523Y	0.22
ESCA	chr16	67638954	3'UTR	novel		0.28
ESCA	chr16	67638181	3'UTR	novel		0.29
GBM	chr16	67626624	Missense_Mutation	novel	F476Y	0.07
GBM	chr16	67626638	Missense_Mutation	novel	A481T	0.07
GBM	chr16	67629468	Missense_Mutation	rs139828150	T591M	0.2
GBM	chr16	67611426	Silent	novel	Q198Q	0.3
GBM	chr16	67628474	Missense_Mutation	novel	H541Q	0.55
HNSC	chr16	67626678	Missense_Mutation	novel	R494L	0.21
HNSC	chr16	67616848	Silent	novel	K352K	0.09
HNSC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.15
HNSC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.25
HNSC	chr16	67611574	Missense_Mutation	novel	N248D	0.25
HNSC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.42
HNSC	chr16	67616853	Missense_Mutation	NA	S354F	0.39
HNSC	chr16	67611338	Frame_Shift_Ins	novel	*A171Gfs20**	0.17
HNSC	chr16	67636797	Nonsense_Mutation	novel	K649*	0.38
HNSC	chr16	67616814	Missense_Mutation	novel	R341H	0.09
HNSC	chr16	67611270	Silent	novel	G146G	0.35
HNSC	chr16	67616751	Missense_Mutation	novel	R320H	0.1
HNSC	chr16	67629446	Frame_Shift_Del	novel	*G585Efs42**	0.25
HNSC	chr16	67629513	Splice_Site	novel	X607_splice	0.13
HNSC	chr16	67626626	Missense_Mutation	novel	H477Y	0.16
HNSC	chr16	67616859	Missense_Mutation	novel	C356F	0.39
HNSC	chr16	67616829	Missense_Mutation	novel	T346S	0.23
HNSC	chr16	67636767	Nonsense_Mutation	novel	Q639*	0.11
KIRC	chr16	67626641	Missense_Mutation	NA	L482I	0.47
KIRP	chr16	67611347	Missense_Mutation	rs761623880	N172S	0.39
LAML	chr16	67610917	Silent	novel	R29R	0.07
LAML	chr16	67636832	Silent	novel	N660N	0.07
LGG	chr16	67629507	Missense_Mutation	NA	S604C	0.12
LGG	chr16	67637924	3'UTR	novel		0.44
LIHC	chr16	67628471	Missense_Mutation	NA	M540I	0.63
LIHC	chr16	67626606	Missense_Mutation	novel	R470H	0.32
LIHC	chr16	67616774	Missense_Mutation	NA	D328Y	0.28
LIHC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.39
LUAD	chr16	67620733	Missense_Mutation	NA	G375R	0.17
LUAD	chr16	67628481	Missense_Mutation	rs112926498	R544C	0.39
LUAD	chr16	67611991	Silent	NA	T274T	0.08
LUAD	chr16	67636850	Missense_Mutation	NA	Q666H	0.2
LUAD	chr16	67626704	Missense_Mutation	NA	A503T	0.7
LUAD	chr16	67610971	Missense_Mutation	NA	G47W	0.32
LUAD	chr16	67628510	Silent	NA	A553A	0.12
LUAD	chr16	67629505	Silent	NA	R603R	0.05
LUSC	chr16	67629464	Missense_Mutation	novel	E590K	0.15
LUSC	chr16	67611087	Missense_Mutation	novel	E85D	0.16
LUSC	chr16	67616842	Silent	novel	P350P	0.6
LUSC	chr16	67628505	Missense_Mutation	NA	P552S	0.34
LUSC	chr16	67628489	Silent	rs373624045	H546H	0.25
LUSC	chr16	67610971	Missense_Mutation	novel	G47R	0.12
LUSC	chr16	67637854	Silent	NA	L722L	0.1
LUSC	chr16	67611536	Missense_Mutation	novel	G235V	0.35
LUSC	chr16	67628540	Silent	NA	T563T	0.28
MESO	chr16	67612091	Missense_Mutation	novel	L308V	0.29
OV	chr16	67612042	Missense_Mutation	NA	E291D	0.84
OV	chr16	67611558	Silent	novel	A242A	0.12
OV	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.4
OV	chr16	67616861	Missense_Mutation	NA	D357N	0.04
OV	chr16	67629442	Silent	NA	G582G	0.12
OV	chr16	67610933	Missense_Mutation	novel	E34A	0.2
PAAD	chr16	67628490	Missense_Mutation	novel	D547Y	0.03
PAAD	chr16	67611968	Nonsense_Mutation	novel	Q267*	0.08
PAAD	chr16	67628463	Missense_Mutation	novel	L538I	0.19
PCPG	chr16	67611603	Missense_Mutation	novel	I257M	0.38
PRAD	chr16	67620713	Missense_Mutation	NA	R368H	0.06
PRAD	chr16	67611511	Missense_Mutation	novel	D227H	0.25
READ	chr16	67620722	Missense_Mutation	NA	R371H	0.24
READ	chr16	67610903	Missense_Mutation	NA	T24S	0.39
READ	chr16	67636785	Missense_Mutation	novel	P645S	0.09
READ	chr16	67616807	Missense_Mutation	novel	R339W	0.44
READ	chr16	67610851	Missense_Mutation	rs779609208	E7K	0.21
READ	chr16	67629503	Missense_Mutation	rs775874494	R603C	0.28
SARC	chr16	67610834	Translation_Start_Site	novel	M1?	0.45
SKCM	chr16	67616845	Silent	NA	F351F	0.08
SKCM	chr16	67636816	Missense_Mutation	NA	P655L	0.26
SKCM	chr16	67610916	Silent	rs371652969	R28R	0.26
SKCM	chr16	67628505	Missense_Mutation	NA	P552S	0.33
SKCM	chr16	67616853	Missense_Mutation	NA	S354F	0.35
SKCM	chr16	67628501	Silent	rs373346637	F550F	0.34
SKCM	chr16	67616791	Silent	NA	T333T	0.15
SKCM	chr16	67611270	Silent	novel	G146G	0.33
STAD	chr16	67636803	Missense_Mutation	rs762060506	R651W	0.3
STAD	chr16	67611372	Frame_Shift_Ins	NA	*E182Gfs9**	0.13
STAD	chr16	67626716	Splice_Site	NA	X506_splice	0.19
STAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.16
STAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.26
STAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.47
STAD	chr16	67637752	Frame_Shift_Del	NA	*E691Sfs30**	0.22
STAD	chr16	67620791	Missense_Mutation	NA	L394P	0.11
STAD	chr16	67612007	Missense_Mutation	NA	N280H	0.1
STAD	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.34
STAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.31
STAD	chr16	67628465	Silent	rs779124853	L538L	0.23
STAD	chr16	67626648	Missense_Mutation	novel	Q484P	0.39
STAD	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.23
STAD	chr16	67611577	Missense_Mutation	rs747052464	M249V	0.59
STAD	chr16	67611435	Frame_Shift_Ins	novel	*T204Kfs19**	0.44
STAD	chr16	67621578	Frame_Shift_Del	rs34679888	*S450Vfs61**	0.18
STAD	chr16	67628506	Missense_Mutation	NA	P552H	0.07
STAD	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.44
STAD	chr16	67616808	Missense_Mutation	NA	R339Q	0.17
STAD	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.27
STAD	chr16	67616773	Silent	NA	C327C	0.13
STAD	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.14
STAD	chr16	67628397	Missense_Mutation	NA	T516A	0.12
STAD	chr16	67612033	Frame_Shift_Del	novel	*H288Qfs22**	0.29
STAD	chr16	67637751	Frame_Shift_Ins	novel	*E691Rfs5**	0.19
STAD	chr16	67626713	Nonsense_Mutation	NA	Q506*	0.31
THCA	chr16	67629437	Missense_Mutation	NA	D581H	0.09
THYM	chr16	67636852	Splice_Site	NA	X667_splice	0.2
UCEC	chr16	67611388	Nonsense_Mutation	NA	Q186*	0.43
UCEC	chr16	67611614	Splice_Site	NA	X261_splice	0.47
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.55
UCEC	chr16	67611283	Frame_Shift_Ins	novel	*P152Tfs11**	0.4
UCEC	chr16	67628435	Nonsense_Mutation	NA	C528*	0.29
UCEC	chr16	67628420	Nonsense_Mutation	NA	Y523*	0.38
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.2
UCEC	chr16	67628548	Missense_Mutation	NA	R566H	0.46
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.27
UCEC	chr16	67616817	Missense_Mutation	NA	R342H	0.03
UCEC	chr16	67620740	Missense_Mutation	NA	R377H	0.48
UCEC	chr16	67620743	Missense_Mutation	NA	P378L	0.34
UCEC	chr16	67610884	Frame_Shift_Del	NA	*G19Efs43**	0.45
UCEC	chr16	67611372	Frame_Shift_Ins	NA	*E182Gfs9**	0.48
UCEC	chr16	67616814	Missense_Mutation	novel	R341H	0.47
UCEC	chr16	67629421	Silent	novel	D575D	0.18
UCEC	chr16	67638735	3'UTR	novel		0.38
UCEC	chr16	67611236	Frame_Shift_Ins	novel	*A137Gfs3**	0.37
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.29
UCEC	chr16	67612104	Missense_Mutation	NA	H312R	0.33
UCEC	chr16	67637776	Silent	rs371078024	P696P	0.27
UCEC	chr16	67638297	3'UTR	novel		0.57
UCEC	chr16	67620704	Missense_Mutation	NA	K365T	0.42
UCEC	chr16	67611444	Frame_Shift_Del	novel	*K206Pfs15**	0.33
UCEC	chr16	67636765	Missense_Mutation	novel	P638H	0.45
UCEC	chr16	67611095	Missense_Mutation	novel	A88V	0.17
UCEC	chr16	67628550	Missense_Mutation	novel	R567W	0.33
UCEC	chr16	67637751	Frame_Shift_Ins	novel	*E691Rfs5**	0.77
UCEC	chr16	67638050	3'UTR	novel		0.82
UCEC	chr16	67621577	Frame_Shift_Ins	novel	*S450Kfs2**	0.24
UCEC	chr16	67616819	Missense_Mutation	NA	Y343H	0.34
UCEC	chr16	67620716	Missense_Mutation	novel	H369R	0.19
UCEC	chr16	67610837	Missense_Mutation	NA	E2G	0.27
UCEC	chr16	67636743	Nonsense_Mutation	NA	E631*	0.28
UCEC	chr16	67620704	Missense_Mutation	NA	K365T	0.28
UCEC	chr16	67626661	Silent	NA	S488S	0.3
UCEC	chr16	67620740	Missense_Mutation	NA	R377H	0.51
UCEC	chr16	67611451	Missense_Mutation	NA	T207P	0.44
UCEC	chr16	67636765	Missense_Mutation	NA	P638L	0.27
UCEC	chr16	67636696	Frame_Shift_Ins	NA	E616*	0.48
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.22
UCEC	chr16	67629402	Missense_Mutation	novel	T569I	0.19
UCEC	chr16	67610971	Frame_Shift_Del	novel	*G48Vfs14**	0.52
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.4
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.17
UCEC	chr16	67611370	Nonsense_Mutation	NA	Q180*	0.39
UCEC	chr16	67626629	Nonsense_Mutation	novel	E478*	0.44
UCEC	chr16	67610971	Frame_Shift_Del	novel	*G48Vfs14**	0.41
UCEC	chr16	67629397	Splice_Site	NA	X568_splice	0.45
UCEC	chr16	67611046	Nonsense_Mutation	NA	Q72*	0.4
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.42
UCEC	chr16	67621511	Frame_Shift_Del	novel	*L427Yfs20**	0.45
UCEC	chr16	67638728	3'UTR	novel		0.31
UCEC	chr16	67611495	Frame_Shift_Del	novel	*D222Mfs28**	0.48
UCEC	chr16	67621580	Missense_Mutation	novel	K449T	0.37
UCEC	chr16	67638854	3'UTR	novel		0.19
UCEC	chr16	67637955	3'UTR	novel		0.31
UCEC	chr16	67620740	Missense_Mutation	NA	R377H	0.09
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.32
UCEC	chr16	67628406	Missense_Mutation	NA	G519R	0.31
UCEC	chr16	67628547	Missense_Mutation	novel	R566C	0.31
UCEC	chr16	67610971	Frame_Shift_Del	novel	*G48Vfs14**	0.48
UCEC	chr16	67611469	Missense_Mutation	novel	R213C	0.34
UCEC	chr16	67637776	Silent	rs371078024	P696P	0.32
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.22
UCEC	chr16	67611265	Nonsense_Mutation	NA	E145*	0.29
UCEC	chr16	67616853	Missense_Mutation	NA	S354F	0.24
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.22
UCEC	chr16	67626692	Nonsense_Mutation	novel	Q499*	0.37
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.33
UCEC	chr16	67611615	Splice_Site	novel	X261_splice	0.6
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.36
UCEC	chr16	67621477	Missense_Mutation	novel	R415W	0.25
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.38
UCEC	chr16	67621492	Missense_Mutation	novel	G420C	0.25
UCEC	chr16	67616859	Missense_Mutation	novel	C356Y	0.38
UCEC	chr16	67628395	Missense_Mutation	NA	R515H	0.52
UCEC	chr16	67629413	Missense_Mutation	novel	H573Y	0.39
UCEC	chr16	67638616	3'UTR	novel		0.28
UCEC	chr16	67571258	5'UTR	novel		0.39
UCEC	chr16	67616773	Silent	NA	C327C	0.45
UCEC	chr16	67621528	Nonsense_Mutation	NA	E432*	0.29
UCEC	chr16	67612103	Missense_Mutation	novel	H312N	0.37
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.45
UCEC	chr16	67637751	Frame_Shift_Ins	novel	*E691Rfs5**	0.49
UCEC	chr16	67620743	Missense_Mutation	NA	P378L	0.39
UCEC	chr16	67611384	Frame_Shift_Ins	NA	*Q186Pfs5**	0.43
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.45
UCEC	chr16	67611286	Frame_Shift_Del	novel	M153*	0.37
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.42
UCEC	chr16	67611599	Frame_Shift_Del	NA	*I257Kfs11**	0.43
UCEC	chr16	67612109	Frame_Shift_Ins	NA	*G318Qfs16**	0.45
UCEC	chr16	67612109	Frame_Shift_Ins	NA	*G318Qfs16**	0.33
UCEC	chr16	67620778	Frame_Shift_Ins	NA	*D390Gfs6**	0.44
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.14
UCEC	chr16	67611237	Frame_Shift_Del	NA	*A137Lfs17**	0.42
UCEC	chr16	67616816	Missense_Mutation	NA	R342C	0.41
UCEC	chr16	67611147	Silent	novel	E105E	0.32
UCEC	chr16	67616820	Missense_Mutation	novel	Y343C	0.35
UCEC	chr16	67638482	3'UTR	novel		0.37
UCEC	chr16	67620743	Missense_Mutation	NA	P378L	0.29
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.34
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.21
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.36
UCEC	chr16	67611613	Missense_Mutation	novel	G261C	0.3
UCEC	chr16	67616862	Frame_Shift_Ins	NA	*Y358Lfs51**	0.23
UCEC	chr16	67638023	3'UTR	novel		0.3
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.48
UCEC	chr16	67626651	Missense_Mutation	NA	H485R	0.06
UCEC	chr16	67616853	Missense_Mutation	NA	S354F	0.41
UCEC	chr16	67626606	Frame_Shift_Del	novel	*R470Lfs41**	0.37
UCEC	chr16	67636767	Nonsense_Mutation	novel	Q639*	0.34
UCEC	chr16	67611423	Nonsense_Mutation	NA	Y197*	0.38
UCEC	chr16	67611424	Nonsense_Mutation	NA	Q198*	0.38
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.52
UCEC	chr16	67611349	Nonsense_Mutation	novel	G173*	0.24
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.38
UCEC	chr16	67636767	Nonsense_Mutation	novel	Q639*	0.37
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.6
UCEC	chr16	67637952	3'UTR	novel		0.26
UCEC	chr16	67636747	Frame_Shift_Del	NA	*I632Mfs10**	0.52
UCEC	chr16	67616807	Missense_Mutation	novel	R339W	0.54
UCEC	chr16	67620722	Missense_Mutation	NA	R371H	0.48
UCEC	chr16	67621477	Missense_Mutation	novel	R415W	0.34
UCEC	chr16	67628465	Silent	rs779124853	L538L	0.48
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.44
UCEC	chr16	67636852	Splice_Site	NA	X667_splice	0.22
UCEC	chr16	67638930	3'UTR	novel		0.16
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.7
UCEC	chr16	67629506	Frame_Shift_Del	NA	*S604Lfs27**	0.36
UCEC	chr16	67638648	3'UTR	novel		0.46
UCEC	chr16	67611367	Nonsense_Mutation	NA	E179*	0.21
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.44
UCEC	chr16	67637924	3'UTR	novel		0.23
UCEC	chr16	67611166	Nonsense_Mutation	NA	E112*	0.19
UCEC	chr16	67638411	3'UTR	novel		0.23
UCEC	chr16	67610930	Missense_Mutation	novel	Q33R	0.28
UCEC	chr16	67638686	3'UTR	novel		0.42
UCEC	chr16	67611338	Frame_Shift_Ins	novel	*A171Gfs20**	0.23
UCEC	chr16	67611509	Missense_Mutation	NA	Y226C	0.3
UCEC	chr16	67628378	Silent	novel	H509H	0.35
UCEC	chr16	67616865	Missense_Mutation	novel	Y358C	0.07
UCEC	chr16	67637751	Frame_Shift_Ins	novel	*E691Rfs5**	0.32
UCEC	chr16	67629464	Nonsense_Mutation	NA	E590*	0.17
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.26
UCEC	chr16	67611436	Frame_Shift_Del	NA	*T204Qfs18**	0.4
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.36
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.31
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.4
UCEC	chr16	67620740	Missense_Mutation	NA	R377H	0.07
UCEC	chr16	67612098	Missense_Mutation	novel	R310M	0.29
UCEC	chr16	67626566	Nonsense_Mutation	NA	R457*	0.41
UCEC	chr16	67621572	Frame_Shift_Del	novel	*A447Vfs61**	0.43
UCEC	chr16	67620739	Missense_Mutation	NA	R377C	0.27
UCEC	chr16	67628395	Missense_Mutation	NA	R515H	0.38
UCEC	chr16	67637786	Nonsense_Mutation	novel	E700*	0.44
UCEC	chr16	67611370	Nonsense_Mutation	NA	Q180*	0.37
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.38
UCEC	chr16	67612109	Frame_Shift_Ins	NA	*G318Qfs16**	0.26
UCEC	chr16	67626566	Nonsense_Mutation	NA	R457*	0.2
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.15
UCEC	chr16	67611166	Nonsense_Mutation	NA	E112*	0.57
UCEC	chr16	67610971	Frame_Shift_Del	novel	*G48Vfs14**	0.43
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.54
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.43
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.3
UCEC	chr16	67621577	Missense_Mutation	novel	R448Q	0.32
UCEC	chr16	67626713	Nonsense_Mutation	NA	Q506*	0.41
UCEC	chr16	67611163	Nonsense_Mutation	novel	G111*	0.36
UCEC	chr16	67610923	Frame_Shift_Del	novel	*G32Afs30**	0.45
UCEC	chr16	67571258	5'UTR	novel		0.29
UCEC	chr16	67626553	Splice_Site	novel	X453_splice	0.27
UCEC	chr16	67637778	Missense_Mutation	novel	A697V	0.39
UCEC	chr16	67611320	Missense_Mutation	NA	G163E	0.29
UCEC	chr16	67611435	Frame_Shift_Ins	NA	*T204Nfs26**	0.23
UCEC	chr16	67621576	Nonsense_Mutation	rs769948988	R448*	0.16
UCEC	chr16	67628400	Missense_Mutation	NA	H517Y	0.22
UCEC	chr16	67621577	Frame_Shift_Ins	novel	*S450Kfs2**	0.41
UCEC	chr16	67628548	Missense_Mutation	NA	R566H	0.21
UCEC	chr16	67638626	3'UTR	rs557253495		0.48
UCEC	chr16	67612109	Frame_Shift_Ins	NA	*G318Qfs16**	0.35
UCEC	chr16	67611969	Missense_Mutation	novel	Q267P	0.33
UCEC	chr16	67628465	Silent	rs779124853	L538L	0.15
UCEC	chr16	67626566	Nonsense_Mutation	NA	R457*	0.38
UCEC	chr16	67616764	Nonsense_Mutation	novel	C324*	0.32
UCEC	chr16	67628449	Missense_Mutation	novel	R533H	0.46
UCS	chr16	67616751	Missense_Mutation	novel	R320H	0.46
UCS	chr16	67611209	Frame_Shift_Del	novel	*A127Pfs4**	0.47
UCS	chr16	67611229	Nonsense_Mutation	novel	E133*	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1912	0.063591
CHOL	DEL	0.1667	0.23475
LAML	DEL	0.0314	0.0010312
TGCT	AMP	0.12	0.035574
UCEC	DEL	0.2839	4.7164e-05

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0014	Kaplan-Meier Survival Analysis
KIRC	0.00013	Kaplan-Meier Survival Analysis
PRAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
BLCA	0.017	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis
UVM	0.019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000102974 (Gene tree)
Gene ID: 10664
Gene Symbol: CTCF
Alias: N
Full Name: CCCTC-binding factor
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 76,779 bases
Position: chr16:67,562,407-67,639,185
Accession: 13723
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26549029	CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression.	Oncogene	2016 Jul 7	Zhao X	doi: 10.1038/onc.2015.422
19826084	A wave of nascent transcription on activated human genes.	Proc Natl Acad Sci U S A	2009 Oct 27	Wada Y	doi: 10.1073/pnas.0902573106
24696455	CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53.	Genes Dev	2014 Apr 1	Saldana-Meyer R	doi: 10.1101/gad.236869.113.
23898036	Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.	J Immunol	2013 Sep 1	Choi NM	doi: 10.4049/jimmunol.1301279
20966046	Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.	Genes Dev	2010 Nov 15	Yao H	doi: 10.1101/gad.1967810
23791181	Jpx RNA activates Xist by evicting CTCF.	Cell	2013 Jun 20	Sun S	doi: 10.1016/j.cell.2013.05.028.
31291573	Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.	Cell Rep	2019 Jul 9	Vara C	doi: 10.1016/j.celrep.2019.06.037.
10906122	Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF.	J Biol Chem	2000 Sep 22	Chernukhin IV	-
21111075	Long-range DNA interactions are specifically altered by locked nucleic acid-targeting of a CTCF binding site.	Biochim Biophys Acta	2011 Jan	Ling JQ	doi: 10.1016/j.bbagrm.2010.11.004
25578877	Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF.	Mol Cell	2015 Jan 22	Kung JT	doi: 10.1016/j.molcel.2014.12.006
29793448	Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits.	BMC Genomics	2018 May 24	Wang M	doi: 10.1186/s12864-018-4800-0.
10625678	An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells.	J Biol Chem	2000 Jan 14	Perez-Juste G	-
25837375	The alternative role of DNA methylation in splicing regulation.	Trends Genet	2015 May	Lev Maor G	doi: 10.1016/j.tig.2015.03.002
29572403	Genome-Wide Mapping of DNA Accessibility and Binding Sites for CREB and C/EBPβ in Vasopressin-Sensitive Collecting Duct Cells.	J Am Soc Nephrol	2018 May	Jung HJ	doi: 10.1681/ASN.2017050545
21059229	CTCF regulates the local epigenetic state of ribosomal DNA repeats.	Epigenetics Chromatin	2010 Nov 8	van de Nobelen S	doi: 10.1186/1756-8935-3-19.
23933634	CTCF depletion alters chromatin structure and transcription of myeloid-specific factors.	J Mol Cell Biol	2013 Oct	Ouboussad L	doi: 10.1093/jmcb/mjt023
19843608	Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene.	Nucleic Acids Res	2009 Dec	Goto Y	doi: 10.1093/nar/gkp860.
21964334	CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing.	Nature	2011 Nov 3	Shukla S	doi: 10.1038/nature10442.
21895576	CTCF function is modulated by neighboring DNA binding factors.	Biochem Cell Biol	2011 Oct	Weth O	doi: 10.1139/o11-033
24659782	Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.	J Biol Chem	2014 May 2	Sheng J	doi: 10.1074/jbc.M114.551762
23884423	Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex.	J Biol Chem	2013 Sep 6	Huang K	doi: 10.1074/jbc.M113.486175
29698677	Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression.	Biochem Biophys Res Commun	2018 Jun 12	Wang F	doi: 10.1016/j.bbrc.2018.04.173
29755673	Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines.	Oncotarget	2018 Apr 17	Riffo-Campos aL	doi: 10.18632/oncotarget.25016
30017906	3D genomic regulation of lncRNA and Xist in X chromosome.	Semin Cell Dev Biol	2019 Jun	Yan F	doi: 10.1016/j.semcdb.2018.07.013
30940740	CTCF: a Swiss-army knife for genome organization and transcription regulation.	Essays Biochem	2019 Apr 23	Braccioli L	doi: 10.1042/EBC20180069
8649389	An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.	Mol Cell Biol	1996 Jun	Filippova GN	-
16285929	Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.	Mol Cell	2005 Nov 11	Cho DH	-
23416946	Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures.	Nat Struct Mol Biol	2013 Mar	Naughton C	doi: 10.1038/nsmb.2509
17512414	High-resolution profiling of histone methylations in the human genome.	Cell	2007 May 18	Barski A	-
22090374	Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells.	Genome Res	2012 Jan	Lee BK	doi: 10.1101/gr.127597.111
21916612	The role of CTCF in coordinating the expression of single gene loci.	Biochem Cell Biol	2011 Oct	Gillen AE	doi: 10.1139/o11-040
21930510	Genome-wide prediction and analysis of human chromatin boundary elements.	Nucleic Acids Res	2012 Jan	Wang J	doi: 10.1093/nar/gkr750
21304052	Estrogen-mediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells.	Carcinogenesis	2011 Jun	Rodriguez BA	doi: 10.1093/carcin/bgr017
23192870	CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase programming.	J Virol	2013 Feb	Kang H	doi: 10.1128/JVI.02283-12
25646466	Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I.	Proc Natl Acad Sci U S A	2015 Feb 17	Pena-Hernandez R	doi: 10.1073/pnas.1416674112
28145452	Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.	Sci Rep	2017 Feb 1	Rivero-Hinojosa S	doi: 10.1038/srep41279.
24321385	Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development.	Biochim Biophys Acta	2014 Jan	Marsman J	doi: 10.1016/j.bbagrm.2013.11.007
24059801	DNA methylation and differentiation: silencing, upregulation and modulation of gene expression.	Epigenomics	2013	Ehrlich M	doi: 10.2217/epi.13.43.
23986576	The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus.	J Virol	2013 Nov	Hilton IB	doi: 10.1128/JVI.01685-13
23533622	A NF-kB-dependent dual promoter-enhancer initiates the lipopolysaccharide-mediated transcriptional activation of the chicken lysozyme in macrophages.	PLoS One	2013	Witham J	doi: 10.1371/journal.pone.0059389
26347501	Long Noncoding RNA CUDR Regulates HULC and β-Catenin to Govern Human Liver Stem Cell Malignant Differentiation.	Mol Ther	2015 Dec	Gui X	doi: 10.1038/mt.2015.166
26686651	CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription.	Cell	2015 Dec 17	Tang Z	doi: 10.1016/j.cell.2015.11.024
26938874	Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.	PLoS One	2016 Mar 3	Qin F	doi: 10.1371/journal.pone.0150382
26216945	MIR retrotransposon sequences provide insulators to the human genome.	Proc Natl Acad Sci U S A	2015 Aug 11	Wang J	doi: 10.1073/pnas.1507253112
28938092	CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.	Mol Cell	2017 Sep 21	Ren G	doi: 10.1016/j.molcel.2017.08.026.
29199022	CTCF-Mediated Chromatin Loops between Promoter and Gene Body Regulate Alternative Splicing across Individuals.	Cell Syst	2017 Dec 27	Ruiz-Velasco M	doi: 10.1016/j.cels.2017.10.018
29235471	CTCF driven TERRA transcription facilitates completion of telomere DNA replication.	Nat Commun	2017 Dec 13	Beishline K	doi: 10.1038/s41467-017-02212-w.
29654311	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus.	Nat Commun	2018 Apr 13	Barutcu AR	doi: 10.1038/s41467-018-03614-0.
29712779	Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes.	J Neurosci	2018 May 23	Galloway A	doi: 10.1523/JNEUROSCI.3349-17.2018
30955885	Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice.	Cell	2019 Apr 18	Canzio D	doi: 10.1016/j.cell.2019.03.008

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000401394	CTCF-202	2797	-	ENSP00000384707	399 (aa)	-	P49711
ENST00000642847	CTCF-206	1174	-	ENSP00000495923	135 (aa)	-	A0A2R8Y6Z6
ENST00000646566	CTCF-216	3952	-	-	- (aa)	-	-
ENST00000645306	CTCF-212	3662	XM_017022869	ENSP00000495218	725 (aa)	XP_016878358	A0A2R8YFL0
ENST00000644950	CTCF-211	2833	-	-	- (aa)	-	-
ENST00000646771	CTCF-217	3706	XM_005255775	ENSP00000494443	725 (aa)	XP_005255832	A0A2R8YFL0
ENST00000643892	CTCF-208	3783	-	ENSP00000494358	638 (aa)	-	A0A2R8Y595
ENST00000646076	CTCF-215	3989	-	ENSP00000494538	727 (aa)	-	P49711
ENST00000644753	CTCF-209	3713	XM_017022868	ENSP00000493495	727 (aa)	XP_016878357	P49711
ENST00000644852	CTCF-210	734	-	ENSP00000495115	163 (aa)	-	A0A2R8Y6C1
ENST00000642819	CTCF-205	3975	-	ENSP00000494408	727 (aa)	-	P49711
ENST00000642420	CTCF-204	2131	-	-	- (aa)	-	-
ENST00000645409	CTCF-213	4271	-	-	- (aa)	-	-
ENST00000264010	CTCF-201	3941	-	ENSP00000264010	727 (aa)	-	P49711
ENST00000566078	CTCF-203	1302	-	-	- (aa)	-	-
ENST00000645699	CTCF-214	3521	-	ENSP00000495348	727 (aa)	-	P49711
ENST00000642943	CTCF-207	4802	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000102974	Cholesterol, HDL	2.203e-008	19060910
ENSG00000102974	Cholesterol, HDL	7.721e-006	19060910

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102974's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102974	CTCF	100	99.387	ENSMUSG00000005698	Ctcf	100	97.962	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	8649389.	IDA	Process
GO:0000775	chromosome, centromeric region	18550811.26321640.	IDA	Component
GO:0000793	condensed chromosome	16107875.	IDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	8649389.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	8649389.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	8649389.9591631.	IDA	Function
GO:0003714	transcription corepressor activity	8649389.	TAS	Function
GO:0005515	protein binding	19505873.19536159.24725430.24937458.25416956.26321640.	IPI	Function
GO:0005634	nucleus	9407128.28319062.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	16107875.16595548.	IDA	Component
GO:0005730	nucleolus	16595548.	IDA	Component
GO:0006306	DNA methylation	-	IEA	Process
GO:0006349	regulation of gene expression by genetic imprinting	-	IEA	Process
GO:0007059	chromosome segregation	-	IEA	Process
GO:0008270	zinc ion binding	8649389.	TAS	Function
GO:0008285	negative regulation of cell proliferation	28319062.	IMP	Process
GO:0010216	maintenance of DNA methylation	-	IEA	Process
GO:0010628	positive regulation of gene expression	18347100.	IMP	Process
GO:0016584	nucleosome positioning	18654629.	IDA	Process
GO:0031060	regulation of histone methylation	-	IEA	Process
GO:0035065	regulation of histone acetylation	-	IEA	Process
GO:0040029	regulation of gene expression, epigenetic	16815976.	IMP	Process
GO:0040030	regulation of molecular function, epigenetic	16815976.	IMP	Process
GO:0043035	chromatin insulator sequence binding	17827499.	IDA	Function
GO:0043565	sequence-specific DNA binding	17827499.	IDA	Function
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0044212	transcription regulatory region DNA binding	18413740.	IDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	8649389.18413740.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	9407128.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	19322193.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0070602	regulation of centromeric sister chromatid cohesion	18550811.	NAS	Process
GO:0071459	protein localization to chromosome, centromeric region	26321640.	IMP	Process

EuRBPDB

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Description

RBPome

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Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

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Note: to get the extension of tumor abbreviations.