EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20217863The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate.Proteomics2010 MayPonce Jdoi: 10.1002/pmic.200900055.
26884185Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.Proc Natl Acad Sci U S A2016 Mar 1Lissanu Deribe Ydoi: 10.1073/pnas.1513801113
25936522Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38Beta expression and activation.Cell Signal2015 SepKim GYdoi: 10.1016/j.cellsig.2015.04.012

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1630185410Splice_Regionnovel0.5
BLCAchr1630187811SilentnovelI281I0.12
BLCAchr1630187881Intronnovel0.28
BLCAchr1630188547Missense_Mutationrs757620393A418T0.59
BLCAchr1630188459SilentnovelL388L0.21
BLCAchr1630186822Missense_MutationnovelE110Q0.16
BLCAchr1630186937Missense_MutationnovelL148P0.2
BLCAchr1630186938Frame_Shift_InsnovelS149*0.21
BLCAchr1630188387Nonsense_MutationNAY364*0.26
BLCAchr1630188245Missense_MutationnovelR354Q0.31
BLCAchr1630186647Missense_MutationnovelP83L0.37
BRCAchr1630186437Intronnovel0.24
BRCAchr1630186831Missense_MutationNAD113H0.18
BRCAchr1630188111Intronnovel0.38
CESCchr1630187929Intronnovel0.54
CESCchr1630187431Missense_MutationnovelV229A0.07
CESCchr1630187734Missense_MutationnovelE256Q0.12
CESCchr1630186842SilentNAL116L0.24
CESCchr1630187519Intronnovel0.17
CESCchr1630187520Intronnovel0.17
CESCchr1630188108Intronnovel0.61
CESCchr1630188397Missense_MutationnovelA368T0.63
CESCchr1630186684Silentrs184262856N95N0.26
COADchr1630185433Intronnovel0.41
COADchr1630185371Silentrs536390638S54S0.33
COADchr1630185271Missense_MutationNAA21V0.32
COADchr1630188288Intronnovel0.4
COADchr1630185403Missense_MutationnovelG65D0.39
COADchr1630187812Missense_MutationNAV282I0.17
COADchr1630188308Intronnovel0.43
COADchr1630187673Intronnovel0.17
COADchr1630187136Missense_MutationnovelD183E0.37
COADchr1630187931Intronnovel0.29
COADchr1630186435Intronnovel0.25
COADchr1630186621Silentrs747607776A74A0.15
COADchr1630188397Missense_MutationnovelA368T0.67
COADchr1630186912Missense_MutationNAH140N0.35
DLBCchr1630188471SilentnovelL392L0.41
DLBCchr1630187142Silentrs745531321S185S0.22
DLBCchr1630188628Intronnovel0.29
ESCAchr1630187049Silentrs762370414N154N0.49
GBMchr1630187399Silentrs772017896H218H0.56
GBMchr1630187034Splice_Regionnovel0.08
GBMchr1630186660Silentrs763085431I87I0.53
GBMchr1630187197Missense_Mutationrs752499984E204K0.29
GBMchr1630186999Intronnovel0.26
HNSCchr1630188195Missense_MutationnovelF337L0.09
HNSCchr1630186540Intronnovel0.17
HNSCchr1630188499Missense_Mutationrs150186033R402W0.39
KIRCchr1630187473Missense_MutationNAS243N0.24
KIRPchr1630188107Intronnovel0.45
LGGchr1630187531Intronnovel0.38
LGGchr1630188443Missense_Mutationrs61736366R383Q0.1
LIHCchr1630188268Intronnovel0.42
LIHCchr1630187142Silentrs745531321S185S0.32
LUADchr1630186684Silentrs184262856N95N0.19
LUADchr1630187861Intronnovel0.28
LUADchr1630187108Missense_MutationNAV174A0.14
LUADchr1630187082Frame_Shift_DelnovelA166Pfs*30.15
LUADchr1630188445Missense_MutationNAD384N0.14
LUADchr1630188297Intronnovel0.24
LUSCchr1630186831Missense_MutationNAD113H0.07
OVchr1630187115SilentnovelP176P0.16
OVchr1630187976Missense_MutationNAS299F0.14
PAADchr1630187035Splice_Regionnovel0.09
READchr1630185371Silentrs536390638S54S0.28
SKCMchr1630187404Missense_MutationNAG220E0.41
SKCMchr1630187692Intronnovel0.48
SKCMchr1630186540Intronnovel0.24
SKCMchr1630188439Missense_MutationnovelG382S0.37
SKCMchr1630188504SilentNAE403E0.36
SKCMchr1630186821Nonsense_MutationNAW109*0.53
SKCMchr1630186756Intronnovel0.38
SKCMchr1630188363Splice_Regionrs752449610S356S0.19
SKCMchr1630186805Intronnovel0.32
SKCMchr1630188495Silentrs757666860K400K0.23
SKCMchr1630186720Missense_MutationNAM107I0.43
SKCMchr1630186744Intronnovel0.46
SKCMchr1630185266SilentNAA19A0.18
SKCMchr1630185386SilentnovelF59F0.41
SKCMchr1630188056Missense_MutationnovelG326S0.31
SKCMchr1630186579Intronnovel0.21
SKCMchr1630187983SilentNAA301A0.37
SKCMchr1630186758Intronnovel0.18
SKCMchr1630186831Missense_MutationNAD113N0.1
SKCMchr1630188062Missense_MutationnovelE328K0.34
STADchr1630188500Missense_MutationNAR402Q0.29
STADchr1630188369SilentNAL358L0.3
STADchr1630186834Frame_Shift_DelnovelG115Afs*20.27
STADchr1630188404Missense_MutationnovelP370H0.05
STADchr1630188399SilentnovelA368A0.44
STADchr1630188500Missense_MutationNAR402Q0.29
STADchr1630185228Missense_MutationNAR7C0.29
STADchr1630187812Missense_MutationNAV282I0.26
STADchr1630187035Splice_Regionnovel0.67
STADchr1630188408Missense_MutationNAD371E0.39
STADchr1630186708SilentNAD103D0.23
STADchr1630188006Missense_MutationNAM309T0.25
STADchr1630187424Missense_MutationNAV227M0.33
THCAchr1630186469Intronnovel0.17
UCECchr1630188128Intronnovel0.36
UCECchr1630188420Silentrs774230354T375T0.22
UCECchr1630186620Missense_Mutationrs373022238A74V0.51
UCECchr1630187187SilentnovelV200V0.28
UCECchr1630186620Missense_Mutationrs373022238A74V0.3
UCECchr1630185267Missense_MutationnovelK20E0.17
UCECchr1630188308Intronnovel0.5
UCECchr1630186663SilentnovelA88A0.06
UCECchr1630188442Missense_MutationNAR383W0.25
UCECchr1630188426Missense_MutationNAE377D0.2
UCECchr1630185367Missense_MutationnovelA53V0.24
UCECchr1630187104Nonsense_MutationNAE173*0.23
UCECchr1630185297Missense_Mutationrs775464405V30I0.52
UCECchr1630186967Intronnovel0.35
UCECchr1630186603SilentnovelG68G0.4
UCECchr1630185375Missense_MutationNAG56R0.28
UCECchr1630188363Splice_Regionrs752449610S356S0.21
UCECchr1630188307Intronnovel0.34
UCECchr1630188082Silentrs377351892I334I0.36
UCECchr1630188320Intronnovel0.34
UCECchr1630186445Intronnovel0.4
UCECchr1630186685Missense_Mutationrs756845489V96I0.28
UCECchr1630187049Silentrs762370414N154N0.41
UCECchr1630187811Silentrs199650298I281I0.38
UCECchr1630188054Missense_MutationnovelR325H0.04
UCECchr1630187081Missense_Mutationrs371653086A165V0.49
UCECchr1630187599Intronnovel0.4
UCECchr1630187450SilentnovelL235L0.51
UCECchr1630187218Missense_Mutationrs371818902V211I0.33
UCECchr1630188535Missense_MutationnovelR414C0.25
UCECchr1630186457Intronnovel0.35
UCECchr1630188317Intronnovel0.49
UCECchr1630186347Intronnovel0.6
UCECchr1630187410Missense_MutationnovelR222Q0.34
UCECchr1630187593Intronnovel0.39
UCECchr1630187702Intronnovel0.19
UCECchr1630188144Intronnovel0.25
UCECchr1630188293Intronnovel0.36
UCECchr1630186362Intronnovel0.36
UVMchr1630185457Intronnovel0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.05560.23475
LUADAMP0.24610.20955

Survival Analysis
CancerP-value Q-value
THYM0.0049

Kaplan-Meier Survival Analysis

KIRC0.0054

Kaplan-Meier Survival Analysis

SARC0.023

Kaplan-Meier Survival Analysis

HNSC0.00038

Kaplan-Meier Survival Analysis

SKCM0.00011

Kaplan-Meier Survival Analysis

BRCA0.013

Kaplan-Meier Survival Analysis

ESCA0.047

Kaplan-Meier Survival Analysis

CESC0.0015

Kaplan-Meier Survival Analysis

LAML0.0026

Kaplan-Meier Survival Analysis

UCEC0.00069

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.00076

Kaplan-Meier Survival Analysis

UVM0.00034

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000102879 (Gene tree)
Gene ID
11151
Gene Symbol
CORO1A
Alias
P57|TACO|HCORO1
Full Name
Coronin 1A
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
6,250 bases
Position
chr16:30,182,827-30,189,076
Accession
2252
RBP type
non-canonical RBP
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000570045CORO1A-2161622XM_011545714ENSP00000455552461 (aa)XP_011544016P31146
ENST00000562129CORO1A-204387--- (aa)--
ENST00000567034CORO1A-2102891--- (aa)--
ENST00000568982CORO1A-212756--- (aa)--
ENST00000569203CORO1A-213582-ENSP00000454752148 (aa)-H3BNA2
ENST00000564768CORO1A-2072236--- (aa)--
ENST00000568763CORO1A-2112809--- (aa)--
ENST00000565497CORO1A-2081348-ENSP00000456457389 (aa)-H3BRY3
ENST00000563778CORO1A-205937-ENSP00000456266249 (aa)-H3BRJ0
ENST00000561849CORO1A-203566--- (aa)--
ENST00000566619CORO1A-209577--- (aa)--
ENST00000569970CORO1A-215714-ENSP00000457509165 (aa)-H3BU76
ENST00000564446CORO1A-206190--- (aa)--
ENST00000570244CORO1A-217844-ENSP00000457332246 (aa)-H3BTU6
ENST00000569469CORO1A-214560--- (aa)--
ENST00000561815CORO1A-202694-ENSP00000456756218 (aa)-H3BSL1
ENST00000219150CORO1A-2011803XM_017022885ENSP00000219150461 (aa)XP_016878374P31146
Gene Model
Click here to download ENSG00000102879's gene model file
Pathways
Pathway IDPathway NameSource
hsa04145PhagosomeKEGG
hsa05152TuberculosisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102879's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001771immunological synapse formation24760828.IMPProcess
GO:0001772immunological synapse24760828.IDAComponent
GO:0001845phagolysosome assembly12132654.IMPProcess
GO:0001891phagocytic cup17442961.IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0003779actin binding23100250.IPIFunction
GO:0003785actin monomer binding23100250.IMPFunction
GO:0005515protein binding11094157.17652161.21988832.25416956.IPIFunction
GO:0005634nucleus17341475.IDAComponent
GO:0005737cytoplasm17341475.IDAComponent
GO:0005769early endosome-IEAComponent
GO:0005829cytosol-IEAComponent
GO:0005884actin filament15800061.IDAComponent
GO:0005886plasma membrane17341475.17442961.IDAComponent
GO:0005911cell-cell junction-IEAComponent
GO:0006816calcium ion transport-IEAProcess
GO:0006909phagocytosis17442961.IMPProcess
GO:0007015actin filament organization-IEAProcess
GO:0008022protein C-terminus binding9365277.IPIFunction
GO:0008092cytoskeletal protein binding-ISSFunction
GO:0008360regulation of cell shape-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0030027lamellipodium17442961.IDAComponent
GO:0030036actin cytoskeleton organization17442961.IMPProcess
GO:0030335positive regulation of cell migration-IEAProcess
GO:0030424axon-IEAComponent
GO:0030595leukocyte chemotaxis-IEAProcess
GO:0030670phagocytic vesicle membrane-IEAComponent
GO:0030864cortical actin cytoskeleton15800061.IDAComponent
GO:0030864cortical actin cytoskeleton24760828.IDAComponent
GO:0031339negative regulation of vesicle fusion-IEAProcess
GO:0031589cell-substrate adhesion17442961.IMPProcess
GO:0032036myosin heavy chain binding23100250.IPIFunction
GO:0032796uropod organization-IEAProcess
GO:0032956regulation of actin cytoskeleton organization24760828.IMPProcess
GO:0032991protein-containing complex11094157.IDAComponent
GO:0038180nerve growth factor signaling pathway-IEAProcess
GO:0042102positive regulation of T cell proliferation-IEAProcess
GO:0042803protein homodimerization activity15601263.IDAFunction
GO:0043029T cell homeostasis-IEAProcess
GO:0043320natural killer cell degranulation24760828.IMPProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0043548phosphatidylinositol 3-kinase binding11094157.IDAFunction
GO:0045087innate immune response17341475.NASProcess
GO:0045335phagocytic vesicle17442961.IDAComponent
GO:0048873homeostasis of number of cells within a tissue-IEAProcess
GO:0050918positive chemotaxis17442961.IDAProcess
GO:0051015actin filament binding7758584.15601263.IDAFunction
GO:0051015actin filament binding22364218.23100250.IMPFunction
GO:0051126negative regulation of actin nucleation17442961.IDAProcess
GO:0051279regulation of release of sequestered calcium ion into cytosol-IEAProcess
GO:0061502early endosome to recycling endosome transport-IEAProcess
GO:0070062extracellular exosome20458337.23533145.HDAComponent
GO:0071353cellular response to interleukin-4-IEAProcess
GO:0098978glutamatergic synapse-IEAComponent
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