EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24170770Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.Mol Cancer Ther2014 FebNing Ydoi: 10.1158/1535-7163.MCT-13-0646
25880010Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer.Br J Cancer2015 Apr 28Ueo Hdoi: 10.1038/bjc.2015.132
23378342Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis.Cancer Res2013 Apr 1Yokobori Tdoi: 10.1158/0008-5472.CAN-12-0326
23549633A common gene variant in PLS3 predicts colon cancer recurrence in women.Tumour Biol2013 AugSzkandera Jdoi: 10.1007/s13277-013-0754-7
26146096Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer.Pol Przegl Chir2015 FebKujawski Rdoi: 10.1515/pjs-2015-0020.
24217791Aberrant expression of plastin-3 via copy number gain induces the epithelial-mesenchymal transition in circulating colorectal cancer cells.Ann Surg Oncol2014 OctSugimachi Kdoi: 10.1245/s10434-013-3366-y

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX115634906Missense_MutationnovelS203C0.29
BLCAchrX115640468Missense_MutationNAE318K0.28
BLCAchrX115622302Missense_MutationnovelA44P0.59
BLCAchrX115635043Missense_MutationNAE249Q0.34
BLCAchrX115634947Missense_MutationNAE217K0.39
BLCAchrX115636925Missense_MutationNAH280D0.32
BLCAchrX115643319Missense_MutationnovelD332H0.2
BRCAchrX115610296Missense_MutationNAE16K0.34
BRCAchrX115636956Missense_MutationNAN290S0.42
BRCAchrX115645023Missense_MutationNAE396K0.26
BRCAchrX115647548Splice_SitenovelX504_splice0.12
BRCAchrX115634072SilentNAF191F0.26
BRCAchrX115636961Missense_MutationnovelF292I0.07
BRCAchrX115634054Missense_Mutationrs781990552K185N0.26
CESCchrX1156503363'UTRnovel0.08
CESCchrX115634068Missense_MutationnovelP190L0.39
CESCchrX115646527SilentNAL501L0.19
CESCchrX115634034Missense_MutationNAD179H0.34
COADchrX115629306Nonsense_MutationnovelG116*0.06
COADchrX115645099Missense_Mutationrs370999829A421V0.26
COADchrX115629863Nonsense_MutationnovelW132*0.07
COADchrX115647894Missense_MutationnovelD546G0.05
COADchrX115629259Missense_MutationNAK100T0.41
COADchrX115634061Missense_MutationnovelL188I0.1
COADchrX115629261Nonsense_MutationNAE101*0.59
COADchrX115645099Missense_Mutationrs370999829A421V0.05
COADchrX115643474SilentNAP383P0.62
ESCAchrX115629283Missense_MutationnovelG108V0.26
GBMchrX115635044Missense_MutationnovelE249A0.44
GBMchrX115643477Missense_MutationnovelE384D0.31
GBMchrX1156496673'UTRnovel0.19
GBMchrX115634020Missense_MutationnovelV174A0.1
HNSCchrX115634983Missense_MutationnovelG229R0.09
HNSCchrX115640480Missense_MutationnovelD322N0.31
HNSCchrX115634906Missense_MutationnovelS203C0.08
HNSCchrX115610245Splice_Regionnovel0.33
HNSCchrX1156495743'UTRnovel0.14
HNSCchrX115643375Silentrs113204501R350R0.13
KIRCchrX115646503SilentNAL493L0.43
KIRPchrX115646144Frame_Shift_InsnovelN446Kfs*20.67
KIRPchrX115649466Missense_MutationNAV600L0.39
LAMLchrX115629257Missense_MutationnovelR99S0.26
LGGchrX115647933Missense_MutationNAI559S0.39
LIHCchrX115629299SilentnovelS113S0.84
LUADchrX115622299Missense_Mutationrs782090562E43Q0.37
LUADchrX115634928SilentNAH210H0.33
LUADchrX115640431SilentNAL305L0.32
LUADchrX115629277Missense_MutationNAL106Q0.32
LUADchrX115647910SilentNAS551S0.54
LUADchrX115645030Missense_MutationnovelR398L0.34
LUADchrX1156496173'UTRnovel0.06
LUADchrX115640404Splice_Regionnovel0.34
LUADchrX115635001Missense_MutationnovelI235V0.59
LUSCchrX115629958Missense_MutationnovelI164T0.37
LUSCchrX115646490Missense_MutationNAG489E0.05
LUSCchrX1156495783'UTRnovel0.11
LUSCchrX115634017Missense_MutationnovelS173L0.73
LUSCchrX115646134Nonsense_MutationnovelW442*0.25
OVchrX115629834Splice_SiteNAX123_splice0.15
OVchrX115646440SilentnovelH472H0.1
READchrX115647561Missense_MutationnovelN508S0.16
READchrX115646162Silentrs782148043P451P0.47
READchrX115640465Missense_MutationnovelG317S0.84
READchrX115643380Missense_MutationnovelF352C0.17
READchrX115629879Nonsense_MutationnovelE138*0.77
READchrX115640443SilentNAI309I0.79
SARCchrX115629285Missense_MutationnovelT109S0.43
SKCMchrX115629215Missense_MutationNAK85N0.53
SKCMchrX1156496073'UTRnovel0.22
SKCMchrX115629852Missense_MutationNAF129I0.7
SKCMchrX115634974SilentNAL226L0.67
SKCMchrX115643432SilentNAF369F0.55
SKCMchrX115634068Missense_MutationnovelP190L0.72
SKCMchrX115636892Missense_MutationNAP269S0.87
SKCMchrX115646491SilentNAG489G0.4
SKCMchrX115646116Missense_MutationNAI436N0.33
STADchrX115647556SilentnovelT506T0.23
STADchrX115635019Missense_MutationNAA241T0.25
STADchrX115643403Missense_MutationNAS360G0.54
THCAchrX1156496133'UTRnovel0.2
UCECchrX1156502053'UTRnovel0.3
UCECchrX115629221SilentNAS87S0.35
UCECchrX115649457Missense_MutationnovelG597R0.37
UCECchrX115646176Missense_MutationNAN456S0.29
UCECchrX115610294Missense_MutationnovelD15A0.34
UCECchrX115636864Missense_MutationnovelE259D0.08
UCECchrX115629885Missense_MutationNAD140Y0.37
UCECchrX115635009SilentNAI237I0.07
UCECchrX115635018Silentrs781887875F240F0.5
UCECchrX115622335Nonsense_MutationNAE55*0.39
UCECchrX115647939Missense_Mutationrs781787553A561V0.48
UCECchrX115622265Missense_MutationnovelF31L0.3
UCECchrX115635009SilentNAI237I0.18
UCECchrX115636855SilentNAR256R0.21
UCECchrX1156496243'UTRnovel0.07
UCECchrX115634043Missense_MutationnovelA182T0.17
UCECchrX115640400Splice_Regionnovel0.25
UCECchrX115643334Missense_MutationNAA337S0.17
UCECchrX1156502053'UTRnovel0.32
UCECchrX1156504833'UTRnovel0.49
UCECchrX115622355Missense_MutationnovelM61I0.33
UCECchrX115635009SilentNAI237I0.08
UCECchrX1156499253'UTRnovel0.31
UCECchrX115629963Missense_MutationnovelL166F0.1
UCECchrX115634930Missense_MutationnovelV211A0.14
UCECchrX1156500933'UTRnovel0.09
UCECchrX115643475Missense_MutationnovelE384K0.23
UCECchrX115640435Missense_MutationNAN307D0.4
UCECchrX115647580SilentnovelG514G0.31
UCECchrX115636945Nonsense_MutationNAW286*0.19
UCECchrX115636906SilentnovelL273L0.23
UCECchrX115646181Frame_Shift_DelnovelK459Sfs*20.15
UCECchrX115649520Missense_MutationnovelV618M0.14
UCECchrX115647664Missense_MutationnovelQ542H0.45
UCECchrX1156501883'UTRnovel0.46
UCECchrX115629236SilentNAT92T0.35
UCECchrX115646078SilentnovelL423L0.26
UCECchrX1156505883'UTRnovel0.38
UCECchrX115643494Nonsense_MutationnovelW390*0.07
UCECchrX115643495Frame_Shift_InsnovelT391Yfs*30.07
UCECchrX115643362Missense_MutationnovelK346T0.18
UCECchrX115647665Missense_MutationnovelS543R0.44
UCECchrX1156501633'UTRnovel0.13
UCECchrX115646128Missense_MutationnovelV440D0.28
UCECchrX1156500433'UTRnovel0.35
UCECchrX115629946Missense_MutationnovelV160G0.48
UCECchrX115634069Silentrs782803490P190P0.33
UCECchrX1156495653'UTRnovel0.42
UCECchrX1156496673'UTRnovel0.5
UCECchrX1156500203'UTRnovel0.39
UCECchrX1156504913'UTRnovel0.38
UCECchrX1156500413'UTRnovel0.21
UCECchrX115629922Missense_MutationnovelN152T0.07
UCECchrX115646186Missense_MutationnovelK459N0.08
UCECchrX115646399Splice_Regionnovel0.45
UCECchrX115645094SilentnovelL419L0.16
UCECchrX1156501043'UTRnovel0.14
UCECchrX1156502053'UTRnovel0.49
UCECchrX115645099Missense_Mutationrs370999829A421V0.08
UCECchrX1156504213'UTRnovel0.09
UCECchrX1156502053'UTRnovel0.33
UCECchrX115649553Missense_MutationnovelR629G0.43
UCECchrX115645099Missense_Mutationrs370999829A421V0.46
UCECchrX1156498763'UTRnovel0.33
UCECchrX115640443SilentNAI309I0.33
UCECchrX1156504823'UTRnovel0.54
UCECchrX115629253Missense_MutationNAN98T0.11
UCECchrX115622311Missense_MutationnovelP47S0.42
UCECchrX115629900Missense_MutationnovelH145Y0.29
UCECchrX115646490Missense_MutationNAG489E0.28
UCECchrX1156496003'UTRnovel0.39
UCSchrX115622321Missense_MutationnovelG50V0.1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.03030.12739
TGCTDEL0.060.08422
THCADEL00.21991

Survival Analysis
CancerP-value Q-value
STAD0.015

Kaplan-Meier Survival Analysis

MESO0.0034

Kaplan-Meier Survival Analysis

ACC0.04

Kaplan-Meier Survival Analysis

UCS0.023

Kaplan-Meier Survival Analysis

HNSC0.00011

Kaplan-Meier Survival Analysis

SKCM0.004

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

PAAD0.00077

Kaplan-Meier Survival Analysis

PCPG0.026

Kaplan-Meier Survival Analysis

BLCA0.00057

Kaplan-Meier Survival Analysis

LAML0.0085

Kaplan-Meier Survival Analysis

THCA0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000102024 (Gene tree)
Gene ID
5358
Gene Symbol
PLS3
Alias
T-plastin
Full Name
plastin 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
90,012 bases
Position
chrX:115,560,850-115,650,861
Accession
9091
RBP type
non-canonical RBP
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000420625PLS3-2033150-ENSP00000398945617 (aa)-A0A0A0MSQ0
ENST00000539310PLS3-2093037-ENSP00000445339630 (aa)-P13797
ENST00000497870PLS3-208568-ENSP00000417728190 (aa)-H7C4N2
ENST00000466150PLS3-204561--- (aa)--
ENST00000489283PLS3-207926-ENSP0000042045842 (aa)-F2Z2Z9
ENST00000355899PLS3-2023280-ENSP00000348163630 (aa)-P13797
ENST00000626746PLS3-210216-ENSP0000048734342 (aa)-F2Z2Z9
ENST00000473026PLS3-205500-ENSP00000475900164 (aa)-U3KQI3
ENST00000289290PLS3-2012277-ENSP00000289290617 (aa)-P13797
ENST00000481823PLS3-2062858-ENSP0000041905142 (aa)-F2Z2Z9
Gene Model
Click here to download ENSG00000102024's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000102024Cholesterol, HDL1.6743558326945E-817903299
ENSG00000102024Cholesterol, HDL4.42655604836833E-717903299
ENSG00000102024Cholesterol, HDL2.36079061442684E-717903299
ENSG00000102024Cholesterol, HDL1.64527388563342E-617903299
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102024's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000102024PLS39979.904ENSG00000136167LCP110079.904Homo_sapiens
ENSG00000102024PLS39979.904ENSMUSG00000021998Lcp110079.904Mus_musculus
ENSG00000102024PLS39938.906YDR129CSAC69839.385Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005509calcium ion binding-IEAFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005884actin filament21873635.IBAComponent
GO:0005886plasma membrane-IDAComponent
GO:0032432actin filament bundle21873635.IBAComponent
GO:0051015actin filament binding21873635.IBAFunction
GO:0051017actin filament bundle assembly21873635.IBAProcess
GO:0051639actin filament network formation21873635.IBAProcess
GO:0060348bone development24088043.IMPProcess
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