EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24170770	Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.	Mol Cancer Ther	2014 Feb	Ning Y	doi: 10.1158/1535-7163.MCT-13-0646
25880010	Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer.	Br J Cancer	2015 Apr 28	Ueo H	doi: 10.1038/bjc.2015.132
23378342	Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis.	Cancer Res	2013 Apr 1	Yokobori T	doi: 10.1158/0008-5472.CAN-12-0326
23549633	A common gene variant in PLS3 predicts colon cancer recurrence in women.	Tumour Biol	2013 Aug	Szkandera J	doi: 10.1007/s13277-013-0754-7
26146096	Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer.	Pol Przegl Chir	2015 Feb	Kujawski R	doi: 10.1515/pjs-2015-0020.
24217791	Aberrant expression of plastin-3 via copy number gain induces the epithelial-mesenchymal transition in circulating colorectal cancer cells.	Ann Surg Oncol	2014 Oct	Sugimachi K	doi: 10.1245/s10434-013-3366-y

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	115634906	Missense_Mutation	novel	S203C	0.29
BLCA	chrX	115640468	Missense_Mutation	NA	E318K	0.28
BLCA	chrX	115622302	Missense_Mutation	novel	A44P	0.59
BLCA	chrX	115635043	Missense_Mutation	NA	E249Q	0.34
BLCA	chrX	115634947	Missense_Mutation	NA	E217K	0.39
BLCA	chrX	115636925	Missense_Mutation	NA	H280D	0.32
BLCA	chrX	115643319	Missense_Mutation	novel	D332H	0.2
BRCA	chrX	115610296	Missense_Mutation	NA	E16K	0.34
BRCA	chrX	115636956	Missense_Mutation	NA	N290S	0.42
BRCA	chrX	115645023	Missense_Mutation	NA	E396K	0.26
BRCA	chrX	115647548	Splice_Site	novel	X504_splice	0.12
BRCA	chrX	115634072	Silent	NA	F191F	0.26
BRCA	chrX	115636961	Missense_Mutation	novel	F292I	0.07
BRCA	chrX	115634054	Missense_Mutation	rs781990552	K185N	0.26
CESC	chrX	115650336	3'UTR	novel		0.08
CESC	chrX	115634068	Missense_Mutation	novel	P190L	0.39
CESC	chrX	115646527	Silent	NA	L501L	0.19
CESC	chrX	115634034	Missense_Mutation	NA	D179H	0.34
COAD	chrX	115629306	Nonsense_Mutation	novel	G116*	0.06
COAD	chrX	115645099	Missense_Mutation	rs370999829	A421V	0.26
COAD	chrX	115629863	Nonsense_Mutation	novel	W132*	0.07
COAD	chrX	115647894	Missense_Mutation	novel	D546G	0.05
COAD	chrX	115629259	Missense_Mutation	NA	K100T	0.41
COAD	chrX	115634061	Missense_Mutation	novel	L188I	0.1
COAD	chrX	115629261	Nonsense_Mutation	NA	E101*	0.59
COAD	chrX	115645099	Missense_Mutation	rs370999829	A421V	0.05
COAD	chrX	115643474	Silent	NA	P383P	0.62
ESCA	chrX	115629283	Missense_Mutation	novel	G108V	0.26
GBM	chrX	115635044	Missense_Mutation	novel	E249A	0.44
GBM	chrX	115643477	Missense_Mutation	novel	E384D	0.31
GBM	chrX	115649667	3'UTR	novel		0.19
GBM	chrX	115634020	Missense_Mutation	novel	V174A	0.1
HNSC	chrX	115634983	Missense_Mutation	novel	G229R	0.09
HNSC	chrX	115640480	Missense_Mutation	novel	D322N	0.31
HNSC	chrX	115634906	Missense_Mutation	novel	S203C	0.08
HNSC	chrX	115610245	Splice_Region	novel		0.33
HNSC	chrX	115649574	3'UTR	novel		0.14
HNSC	chrX	115643375	Silent	rs113204501	R350R	0.13
KIRC	chrX	115646503	Silent	NA	L493L	0.43
KIRP	chrX	115646144	Frame_Shift_Ins	novel	*N446Kfs2**	0.67
KIRP	chrX	115649466	Missense_Mutation	NA	V600L	0.39
LAML	chrX	115629257	Missense_Mutation	novel	R99S	0.26
LGG	chrX	115647933	Missense_Mutation	NA	I559S	0.39
LIHC	chrX	115629299	Silent	novel	S113S	0.84
LUAD	chrX	115622299	Missense_Mutation	rs782090562	E43Q	0.37
LUAD	chrX	115634928	Silent	NA	H210H	0.33
LUAD	chrX	115640431	Silent	NA	L305L	0.32
LUAD	chrX	115629277	Missense_Mutation	NA	L106Q	0.32
LUAD	chrX	115647910	Silent	NA	S551S	0.54
LUAD	chrX	115645030	Missense_Mutation	novel	R398L	0.34
LUAD	chrX	115649617	3'UTR	novel		0.06
LUAD	chrX	115640404	Splice_Region	novel		0.34
LUAD	chrX	115635001	Missense_Mutation	novel	I235V	0.59
LUSC	chrX	115629958	Missense_Mutation	novel	I164T	0.37
LUSC	chrX	115646490	Missense_Mutation	NA	G489E	0.05
LUSC	chrX	115649578	3'UTR	novel		0.11
LUSC	chrX	115634017	Missense_Mutation	novel	S173L	0.73
LUSC	chrX	115646134	Nonsense_Mutation	novel	W442*	0.25
OV	chrX	115629834	Splice_Site	NA	X123_splice	0.15
OV	chrX	115646440	Silent	novel	H472H	0.1
READ	chrX	115647561	Missense_Mutation	novel	N508S	0.16
READ	chrX	115646162	Silent	rs782148043	P451P	0.47
READ	chrX	115640465	Missense_Mutation	novel	G317S	0.84
READ	chrX	115643380	Missense_Mutation	novel	F352C	0.17
READ	chrX	115629879	Nonsense_Mutation	novel	E138*	0.77
READ	chrX	115640443	Silent	NA	I309I	0.79
SARC	chrX	115629285	Missense_Mutation	novel	T109S	0.43
SKCM	chrX	115629215	Missense_Mutation	NA	K85N	0.53
SKCM	chrX	115649607	3'UTR	novel		0.22
SKCM	chrX	115629852	Missense_Mutation	NA	F129I	0.7
SKCM	chrX	115634974	Silent	NA	L226L	0.67
SKCM	chrX	115643432	Silent	NA	F369F	0.55
SKCM	chrX	115634068	Missense_Mutation	novel	P190L	0.72
SKCM	chrX	115636892	Missense_Mutation	NA	P269S	0.87
SKCM	chrX	115646491	Silent	NA	G489G	0.4
SKCM	chrX	115646116	Missense_Mutation	NA	I436N	0.33
STAD	chrX	115647556	Silent	novel	T506T	0.23
STAD	chrX	115635019	Missense_Mutation	NA	A241T	0.25
STAD	chrX	115643403	Missense_Mutation	NA	S360G	0.54
THCA	chrX	115649613	3'UTR	novel		0.2
UCEC	chrX	115650205	3'UTR	novel		0.3
UCEC	chrX	115629221	Silent	NA	S87S	0.35
UCEC	chrX	115649457	Missense_Mutation	novel	G597R	0.37
UCEC	chrX	115646176	Missense_Mutation	NA	N456S	0.29
UCEC	chrX	115610294	Missense_Mutation	novel	D15A	0.34
UCEC	chrX	115636864	Missense_Mutation	novel	E259D	0.08
UCEC	chrX	115629885	Missense_Mutation	NA	D140Y	0.37
UCEC	chrX	115635009	Silent	NA	I237I	0.07
UCEC	chrX	115635018	Silent	rs781887875	F240F	0.5
UCEC	chrX	115622335	Nonsense_Mutation	NA	E55*	0.39
UCEC	chrX	115647939	Missense_Mutation	rs781787553	A561V	0.48
UCEC	chrX	115622265	Missense_Mutation	novel	F31L	0.3
UCEC	chrX	115635009	Silent	NA	I237I	0.18
UCEC	chrX	115636855	Silent	NA	R256R	0.21
UCEC	chrX	115649624	3'UTR	novel		0.07
UCEC	chrX	115634043	Missense_Mutation	novel	A182T	0.17
UCEC	chrX	115640400	Splice_Region	novel		0.25
UCEC	chrX	115643334	Missense_Mutation	NA	A337S	0.17
UCEC	chrX	115650205	3'UTR	novel		0.32
UCEC	chrX	115650483	3'UTR	novel		0.49
UCEC	chrX	115622355	Missense_Mutation	novel	M61I	0.33
UCEC	chrX	115635009	Silent	NA	I237I	0.08
UCEC	chrX	115649925	3'UTR	novel		0.31
UCEC	chrX	115629963	Missense_Mutation	novel	L166F	0.1
UCEC	chrX	115634930	Missense_Mutation	novel	V211A	0.14
UCEC	chrX	115650093	3'UTR	novel		0.09
UCEC	chrX	115643475	Missense_Mutation	novel	E384K	0.23
UCEC	chrX	115640435	Missense_Mutation	NA	N307D	0.4
UCEC	chrX	115647580	Silent	novel	G514G	0.31
UCEC	chrX	115636945	Nonsense_Mutation	NA	W286*	0.19
UCEC	chrX	115636906	Silent	novel	L273L	0.23
UCEC	chrX	115646181	Frame_Shift_Del	novel	*K459Sfs2**	0.15
UCEC	chrX	115649520	Missense_Mutation	novel	V618M	0.14
UCEC	chrX	115647664	Missense_Mutation	novel	Q542H	0.45
UCEC	chrX	115650188	3'UTR	novel		0.46
UCEC	chrX	115629236	Silent	NA	T92T	0.35
UCEC	chrX	115646078	Silent	novel	L423L	0.26
UCEC	chrX	115650588	3'UTR	novel		0.38
UCEC	chrX	115643494	Nonsense_Mutation	novel	W390*	0.07
UCEC	chrX	115643495	Frame_Shift_Ins	novel	*T391Yfs3**	0.07
UCEC	chrX	115643362	Missense_Mutation	novel	K346T	0.18
UCEC	chrX	115647665	Missense_Mutation	novel	S543R	0.44
UCEC	chrX	115650163	3'UTR	novel		0.13
UCEC	chrX	115646128	Missense_Mutation	novel	V440D	0.28
UCEC	chrX	115650043	3'UTR	novel		0.35
UCEC	chrX	115629946	Missense_Mutation	novel	V160G	0.48
UCEC	chrX	115634069	Silent	rs782803490	P190P	0.33
UCEC	chrX	115649565	3'UTR	novel		0.42
UCEC	chrX	115649667	3'UTR	novel		0.5
UCEC	chrX	115650020	3'UTR	novel		0.39
UCEC	chrX	115650491	3'UTR	novel		0.38
UCEC	chrX	115650041	3'UTR	novel		0.21
UCEC	chrX	115629922	Missense_Mutation	novel	N152T	0.07
UCEC	chrX	115646186	Missense_Mutation	novel	K459N	0.08
UCEC	chrX	115646399	Splice_Region	novel		0.45
UCEC	chrX	115645094	Silent	novel	L419L	0.16
UCEC	chrX	115650104	3'UTR	novel		0.14
UCEC	chrX	115650205	3'UTR	novel		0.49
UCEC	chrX	115645099	Missense_Mutation	rs370999829	A421V	0.08
UCEC	chrX	115650421	3'UTR	novel		0.09
UCEC	chrX	115650205	3'UTR	novel		0.33
UCEC	chrX	115649553	Missense_Mutation	novel	R629G	0.43
UCEC	chrX	115645099	Missense_Mutation	rs370999829	A421V	0.46
UCEC	chrX	115649876	3'UTR	novel		0.33
UCEC	chrX	115640443	Silent	NA	I309I	0.33
UCEC	chrX	115650482	3'UTR	novel		0.54
UCEC	chrX	115629253	Missense_Mutation	NA	N98T	0.11
UCEC	chrX	115622311	Missense_Mutation	novel	P47S	0.42
UCEC	chrX	115629900	Missense_Mutation	novel	H145Y	0.29
UCEC	chrX	115646490	Missense_Mutation	NA	G489E	0.28
UCEC	chrX	115649600	3'UTR	novel		0.39
UCS	chrX	115622321	Missense_Mutation	novel	G50V	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.0303	0.12739
TGCT	DEL	0.06	0.08422
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
STAD	0.015	Kaplan-Meier Survival Analysis
MESO	0.0034	Kaplan-Meier Survival Analysis
ACC	0.04	Kaplan-Meier Survival Analysis
UCS	0.023	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.004	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.00077	Kaplan-Meier Survival Analysis
PCPG	0.026	Kaplan-Meier Survival Analysis
BLCA	0.00057	Kaplan-Meier Survival Analysis
LAML	0.0085	Kaplan-Meier Survival Analysis
THCA	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000102024 (Gene tree)
Gene ID: 5358
Gene Symbol: PLS3
Alias: T-plastin
Full Name: plastin 3
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 90,012 bases
Position: chrX:115,560,850-115,650,861
Accession: 9091
Summary: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000420625	PLS3-203	3150	-	ENSP00000398945	617 (aa)	-	A0A0A0MSQ0
ENST00000539310	PLS3-209	3037	-	ENSP00000445339	630 (aa)	-	P13797
ENST00000497870	PLS3-208	568	-	ENSP00000417728	190 (aa)	-	H7C4N2
ENST00000466150	PLS3-204	561	-	-	- (aa)	-	-
ENST00000489283	PLS3-207	926	-	ENSP00000420458	42 (aa)	-	F2Z2Z9
ENST00000355899	PLS3-202	3280	-	ENSP00000348163	630 (aa)	-	P13797
ENST00000626746	PLS3-210	216	-	ENSP00000487343	42 (aa)	-	F2Z2Z9
ENST00000473026	PLS3-205	500	-	ENSP00000475900	164 (aa)	-	U3KQI3
ENST00000289290	PLS3-201	2277	-	ENSP00000289290	617 (aa)	-	P13797
ENST00000481823	PLS3-206	2858	-	ENSP00000419051	42 (aa)	-	F2Z2Z9

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000102024	Cholesterol, HDL	1.6743558326945E-8	17903299
ENSG00000102024	Cholesterol, HDL	4.42655604836833E-7	17903299
ENSG00000102024	Cholesterol, HDL	2.36079061442684E-7	17903299
ENSG00000102024	Cholesterol, HDL	1.64527388563342E-6	17903299

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102024's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102024	PLS3	99	79.904	ENSG00000136167	LCP1	100	79.904	Homo_sapiens
ENSG00000102024	PLS3	99	79.904	ENSMUSG00000021998	Lcp1	100	79.904	Mus_musculus
ENSG00000102024	PLS3	99	38.906	YDR129C	SAC6	98	39.385	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005884	actin filament	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0032432	actin filament bundle	21873635.	IBA	Component
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051017	actin filament bundle assembly	21873635.	IBA	Process
GO:0051639	actin filament network formation	21873635.	IBA	Process
GO:0060348	bone development	24088043.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.