EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26938858Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer.Cell Physiol Biochem2016Zhu Ydoi: 10.1159/000443051
16465409Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases.Oncol Rep2006 MarShinji S-
17553343[Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2007 JunYang Y-
25429837Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer.Med Oncol2015 JanWang Ydoi: 10.1007/s12032-014-0379-8
26712154Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis.J Mol Histol2016 FebZhu Ldoi: 10.1007/s10735-015-9650-3
28151478Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.Cell Death Dis2017 Feb 2Liao Ydoi: 10.1038/cddis.2016.477.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr18211255Missense_Mutationrs763757165E486K0.3
BLCAchr18209994SilentnovelQ396Q0.31
BLCAchr18163451Nonsense_MutationnovelK54*0.13
BLCAchr18179002Missense_Mutationrs141269921V89I0.51
BLCAchr18178985Missense_MutationnovelS83L0.31
BLCAchr18179008Missense_MutationnovelD91Y0.17
BRCAchr182113893'UTRnovel0.6
BRCAchr182134983'UTRnovel0.17
BRCAchr18210024Silentrs772506851F406F0.33
BRCAchr18178978Nonsense_MutationNAE81*0.2
BRCAchr18211283In_Frame_Insnovel0.1
CESCchr182135843'UTRnovel0.43
CESCchr18198112Silentrs189562044F247F0.25
CESCchr18198131Missense_Mutationrs374300842T254A0.12
COADchr18198113Missense_MutationNAG248S0.19
COADchr18203145Frame_Shift_InsNAY333Lfs*20.33
COADchr18196734Silentrs374980775A187A0.19
COADchr18163331Missense_MutationNAK14Q0.11
COADchr18199221In_Frame_Delrs758112641E264del0.23
COADchr18179023Nonsense_MutationnovelQ96Hfs*30.06
COADchr18179025Missense_MutationnovelQ96H0.02
ESCAchr18211238Missense_MutationnovelY480C0.16
ESCAchr18203180Missense_MutationnovelK342R0.5
GBMchr18199242Nonsense_MutationnovelG268*0.34
GBMchr18202881Missense_MutationnovelR293Q0.19
GBMchr18180305Missense_MutationnovelR124C0.18
KICHchr18211193Missense_MutationnovelR465L0.44
KIRPchr182113613'UTRnovel0.33
KIRPchr18163336Missense_MutationNAF15L0.7
KIRPchr18192871Frame_Shift_DelnovelM146Wfs*620.44
LGGchr18202880Nonsense_MutationNAR293*0.17
LGGchr18197620Missense_MutationnovelA200V0.24
LUADchr18210491Missense_MutationnovelQ444L0.15
LUADchr18197634Missense_MutationNAI205L0.18
LUADchr18196747Missense_MutationNAQ192K0.13
LUADchr18178978Missense_MutationNAE81K0.15
LUADchr18202918Missense_MutationnovelL305F0.24
LUADchr18180238Missense_MutationNAM101I0.7
LUSCchr18192857SilentnovelL140L0.63
OVchr18198094Missense_MutationNAS241R0.35
OVchr18192876Missense_MutationnovelA147T0.05
OVchr18211269Missense_MutationNAE490D0.28
OVchr18198062Missense_MutationnovelA231T0.05
OVchr18211231Missense_MutationnovelL478V0.55
PAADchr18163369SilentnovelP26P0.21
PAADchr18197615Splice_SitenovelX199_splice0.15
PRADchr18163395Missense_Mutationrs201080569A35V0.6
PRADchr18179030Missense_MutationnovelA98V0.48
PRADchr18192883Missense_Mutationrs577282582A149V0.39
PRADchr18198100SilentnovelI243I0.33
READchr182115173'UTRnovel0.31
SARCchr182116173'UTRnovel0.14
SKCMchr18163367Missense_Mutationrs201975297P26S0.54
SKCMchr18203129Missense_MutationnovelT325I0.39
SKCMchr18203147Missense_MutationnovelF331Y0.4
SKCMchr18180332Missense_MutationnovelL133F0.29
SKCMchr18180333Missense_MutationnovelL133P0.29
STADchr18166813Frame_Shift_DelnovelN65Mfs*30.29
STADchr18211247Missense_Mutationrs757981348R483H0.19
STADchr18196666Missense_MutationnovelK165E0.08
STADchr18196733Missense_MutationNAA187V0.23
STADchr18211172Missense_MutationNAV458A0.5
STADchr18196658Missense_MutationnovelS162F0.33
STADchr18209989Frame_Shift_DelnovelQ396Rfs*290.12
STADchr18211160Missense_MutationNAK454T0.29
STADchr18203146Frame_Shift_DelnovelY333Ifs*70.29
STADchr18203145Frame_Shift_InsNAY333Lfs*20.23
UCECchr18203144Missense_MutationNAR330Q0.28
UCECchr18202881Missense_MutationnovelR293Q0.05
UCECchr181585365'Flanknovel0.29
UCECchr18166795Missense_MutationNAD57E0.28
UCECchr18203173Missense_MutationNAN340H0.5
UCECchr18204645Missense_MutationNAK373Q0.48
UCECchr18204640Missense_MutationnovelR371Q0.63
UCECchr18163330Missense_Mutationrs370161815E13D0.39
UCECchr18202912SilentnovelP303P0.32
UCECchr182115313'UTRnovel0.57
UCECchr182145293'UTRnovel0.75
UCECchr18210009SilentNAY401Y0.06
UCECchr182146223'UTRnovel0.46
UCECchr182114623'UTRnovel0.29
UCECchr18211183Missense_MutationnovelD462Y0.16
UCECchr18178938Missense_MutationNAM67I0.43
UCECchr18163346Missense_MutationnovelE19K0.42
UCECchr18197642Missense_MutationnovelM207I0.3
UCECchr18199215Nonsense_MutationnovelE259*0.37
UCECchr182118063'UTRnovel0.37
UCECchr18204623Missense_Mutationrs750713987E365D0.07
UCECchr18163432Missense_MutationnovelM47I0.32
UCECchr18199211SilentnovelC257C0.35
UCECchr18204669Nonsense_MutationnovelK381*0.67
UCECchr182136543'UTRnovel0.41
UCECchr18199213Frame_Shift_DelnovelT258Kfs*670.27
UCECchr182134563'UTRnovel0.38
UCECchr182146133'UTRnovel0.3
UCECchr18196635Splice_SitenovelX155_splice0.17
UCECchr182118153'UTRnovel0.22
UCECchr182136543'UTRnovel0.17
UCECchr182145833'UTRnovel0.19
UCECchr18197624SilentnovelN201N0.61
UCECchr182135533'UTRnovel0.45
UCECchr18211222Missense_Mutationrs773654673A475T0.28
UCECchr182118713'UTRnovel0.45
UCECchr182135223'UTRnovel0.47
UCECchr182118393'UTRnovel0.48
UCECchr182116483'UTRnovel0.49
UCECchr18203111Missense_MutationnovelR319Q0.12
UCECchr18204640Missense_MutationnovelR371Q0.12
UCECchr182117273'UTRnovel0.29
UCECchr18211171Missense_MutationnovelV458I0.07
UCECchr18163365Missense_MutationnovelP25H0.33
UCECchr18203144Missense_MutationNAR330Q0.37
UCECchr18180243Missense_MutationnovelL103S0.42
UCECchr182145873'UTRnovel0.31
UCECchr18203147Missense_MutationNAF331C0.28
UCECchr182113623'UTRnovel0.27
UCECchr18180306Missense_Mutationrs749757792R124H0.53
UCECchr182112963'UTRnovel0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LUSCAMP0.26950.19322
PAADDEL0.14130.12313
SARCDEL0.21790.24876
TGCTDEL0.68670.00046313

Survival Analysis
CancerP-value Q-value
KIRC0.036

Kaplan-Meier Survival Analysis

SARC0.0039

Kaplan-Meier Survival Analysis

MESO0.012

Kaplan-Meier Survival Analysis

ACC0.0013

Kaplan-Meier Survival Analysis

HNSC0.00024

Kaplan-Meier Survival Analysis

CESC0.035

Kaplan-Meier Survival Analysis

UCEC0.0051

Kaplan-Meier Survival Analysis

LIHC0.00028

Kaplan-Meier Survival Analysis

LGG0.011

Kaplan-Meier Survival Analysis

LUAD0.0026

Kaplan-Meier Survival Analysis

UVM0.049

Kaplan-Meier Survival Analysis

OV0.0011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000101557 (Gene tree)
Gene ID
9097
Gene Symbol
USP14
Alias
TGT
Full Name
ubiquitin specific peptidase 14
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
56,247 bases
Position
chr18:158,383-214,629
Accession
12612
RBP type
non-canonical RBP
Summary
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000578786USP14-2041104--- (aa)--
ENST00000580410USP14-206474-ENSP0000046389120 (aa)-J3QQT6
ENST00000581983USP14-207503-ENSP0000046231528 (aa)-J3KS55
ENST00000582707USP14-2081803-ENSP00000464447459 (aa)-P54578
ENST00000261601USP14-2014921-ENSP00000261601494 (aa)-P54578
ENST00000583119USP14-209578-ENSP0000047356333 (aa)-R4GNB0
ENST00000400266USP14-2031681-ENSP00000383125483 (aa)-P54578
ENST00000578942USP14-2053189--- (aa)--
ENST00000383589USP14-2022168-ENSP00000373083448 (aa)-A6NJA2
Gene Model
Click here to download ENSG00000101557's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101557's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000101557USP1410085.000WBGene00006856usp-149441.551Caenorhabditis_elegans
ENSG00000101557USP14100100.000ENSMUSG00000047879Usp1410096.950Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000502proteasome complex-IEAComponent
GO:0004197cysteine-type endopeptidase activity9827704.TASFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity23958854.IDAFunction
GO:0004866endopeptidase inhibitor activity18162577.IMPFunction
GO:0005515protein binding19106094.19135427.19896943.IPIFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IEAComponent
GO:0006511ubiquitin-dependent protein catabolic process-IEAProcess
GO:0007268chemical synaptic transmission-IEAProcess
GO:0008193tRNA guanylyltransferase activity8579355.TASFunction
GO:0009986cell surface19106094.IDAComponent
GO:0010951negative regulation of endopeptidase activity-IEAProcess
GO:0016579protein deubiquitination23958854.IDAProcess
GO:0016579protein deubiquitination-TASProcess
GO:0031410cytoplasmic vesicle19106094.IDAComponent
GO:0036459thiol-dependent ubiquitinyl hydrolase activity19106094.IDAFunction
GO:0045087innate immune response-IEAProcess
GO:0045202synapse-IEAComponent
GO:0050920regulation of chemotaxis19106094.IMPProcess
GO:0061136regulation of proteasomal protein catabolic process18162577.IMPProcess
GO:0070062extracellular exosome23533145.HDAComponent
GO:0070628proteasome binding18162577.IDAFunction
GO:0099116tRNA 5'-end processing-IEAProcess
GO:1903070negative regulation of ER-associated ubiquitin-dependent protein catabolic process19135427.IMPProcess
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