EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27208742End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis.Clin Chim Acta2016 Aug 1Kumar Mdoi: 10.1016/j.cca.2016.05.012
23900080Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction.Cancer Lett2013 Oct 1Kim MJdoi: 10.1016/j.canlet.2013.07.027
22277732Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.Cancer Prev Res (Phila)2012 AprLadd JJdoi: 10.1158/1940-6207.CAPR-11-0412
26342024MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.Cancer Prev Res (Phila)2015 NovTaguchi Adoi: 10.1158/1940-6207.CAPR-15-0077
22735596Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer.J Proteomics2012 Sep 18Sugihara Ydoi: 10.1016/j.jprot.2012.06.013

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2032846725Frame_Shift_DelnovelN235Kfs*90.11
BLCAchr2032836715Missense_MutationnovelA117T0.68
BLCAchr2032836733Missense_MutationnovelD123N0.49
BLCAchr2032839732Splice_Regionnovel0.17
BLCAchr20328487733'UTRnovel0.48
BLCAchr2032833797Missense_MutationnovelE68Q0.22
BRCAchr2032846653SilentNAE211E0.2
BRCAchr2032833731Nonsense_MutationNAQ46*0.13
BRCAchr20328499373'UTRnovel0.14
CESCchr20328488803'UTRnovel0.12
CESCchr20328498203'UTRnovel0.11
COADchr2032846674Silentrs762741175F218F0.38
COADchr2032848696Frame_Shift_DelnovelG260Afs*280.28
COADchr2032826032Silentrs565248642I35I0.21
COADchr2032848697Missense_MutationNAG259E0.17
COADchr2032833852Missense_MutationnovelG86D0.06
ESCAchr2032846766Missense_MutationnovelT249I0.21
ESCAchr2032836712Missense_Mutationrs758889318D116N0.18
GBMchr2032826003Missense_MutationnovelE26Q0.11
GBMchr2032833772Missense_MutationnovelK59N0.15
HNSCchr20328487413'UTRnovel0.35
HNSCchr2032836721Frame_Shift_DelnovelY119*0.12
HNSCchr2032826009Missense_MutationnovelL28V0.4
HNSCchr2032846680SilentnovelK220K0.3
KIRPchr2032825953In_Frame_DelnovelV10_T11del0.58
LIHCchr20328489163'UTRnovel0.23
LUADchr2032848690Missense_MutationNAD257N0.48
LUSCchr2032833792Missense_MutationNAK66T0.45
LUSCchr20328488343'UTRnovel0.22
LUSCchr20328487923'UTRnovel0.13
LUSCchr2032846740SilentnovelQ240Q0.24
LUSCchr2032846654Missense_MutationnovelK212Q0.15
LUSCchr2032836682Missense_MutationnovelE106Q0.31
LUSCchr2032826049Splice_SitenovelX41_splice0.24
MESOchr2032826044Nonsense_MutationnovelC39*0.31
OVchr2032846685Missense_MutationnovelR222L0.04
PAADchr2032825977Missense_MutationnovelR17Q0.19
PAADchr2032836646Missense_MutationnovelD94N0.15
PAADchr2032846686SilentnovelR222R0.19
PRADchr2032833734Frame_Shift_DelnovelF47Lfs*120.39
PRADchr2032836663SilentNAG99G0.16
READchr2032826020Missense_MutationnovelN31K0.1
SKCMchr2032839781SilentNAK174K0.25
SKCMchr2032836781Missense_MutationNAP139S0.33
SKCMchr2032836782Missense_MutationNAP139L0.33
SKCMchr2032833820SilentNAF75F0.43
SKCMchr2032836687Silentrs754319096F107F0.26
STADchr2032839771Missense_Mutationrs199851862A171V0.39
STADchr2032839737Missense_MutationNAP160S0.14
UCECchr2032826033Missense_Mutationrs753378763E36K0.4
UCECchr2032846660Missense_MutationnovelR214G0.19
UCECchr2032839805Missense_Mutationrs753923516K182N0.44
UCECchr2032833855Missense_Mutationrs770912318V87A0.36
UCECchr2032836740Missense_MutationnovelD125G0.54
UCECchr2032833815Missense_MutationnovelN74H0.26
UCECchr2032825978SilentNAR17R0.12
UCECchr2032836731Missense_MutationnovelK122T0.08
UCECchr20328487953'UTRnovel0.44
UCECchr20328500983'UTRnovel0.37
UCECchr20328495003'UTRnovel0.56
UCECchr20328497783'UTRnovel0.29
UCECchr20328500863'UTRnovel0.21
UCECchr2032848723Missense_MutationnovelY268H0.45
UCECchr20328496353'UTRnovel0.45
UCECchr2032833861Missense_MutationnovelK89T0.52
UCECchr20328503553'UTRnovel0.24
UCECchr20328499293'UTRnovel0.5
UCECchr20328503553'UTRnovel0.48
UCECchr2032836766Nonsense_MutationnovelE134*0.21
UCECchr2032846653SilentNAE211E0.2
UCECchr20328497783'UTRnovel0.21
UCECchr20328502883'UTRnovel0.16
UCECchr20328489923'UTRnovel0.21
UCECchr2032848727Silentnovel*269*0.57
UCECchr2032836702Missense_Mutationrs375430356K112N0.54
UCECchr2032825977Missense_MutationnovelR17Q0.14
UCECchr2032825955Missense_MutationNAV10M0.27
UCECchr2032839801Missense_Mutationrs547725771R181Q0.29
UCECchr20328503553'UTRnovel0.28
UCECchr20328488493'UTRnovel0.37
UCECchr2032833836Missense_MutationnovelG81C0.07
UCSchr2032836661Nonsense_MutationnovelG99*0.29

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.01050.14746
READAMP0.86671.9519e-21

Survival Analysis
CancerP-value Q-value
THYM0.0031

Kaplan-Meier Survival Analysis

STAD0.036

Kaplan-Meier Survival Analysis

MESO0.00041

Kaplan-Meier Survival Analysis

ACC0.00067

Kaplan-Meier Survival Analysis

HNSC0.041

Kaplan-Meier Survival Analysis

LUSC0.028

Kaplan-Meier Survival Analysis

ESCA0.0024

Kaplan-Meier Survival Analysis

UCEC0.0015

Kaplan-Meier Survival Analysis

LIHC0.0014

Kaplan-Meier Survival Analysis

LUAD0.045

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000101367 (Gene tree)
Gene ID
22919
Gene Symbol
MAPRE1
Alias
EB1
Full Name
microtubule associated protein RP/EB family member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
30,626 bases
Position
chr20:32,819,780-32,850,405
Accession
6890
RBP type
non-canonical RBP
Summary
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22869553Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes.Mol Cell Proteomics2012 NovWang LJdoi: 10.1074/mcp.M112.020594
16247022Melanophilin and myosin Va track the microtubule plus end on EB1.J Cell Biol2005 Oct 24Wu XS-
20351264Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.Proc Natl Acad Sci U S A2010 Apr 13Lavieu Gdoi: 10.1073/pnas.1002536107
26504169Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells.J Cell Biol2015 Oct 26Jovasevic Vdoi: 10.1083/jcb.201505123.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000375571MAPRE1-2012623XM_011528696ENSP00000364721268 (aa)XP_011526998Q15691
Gene Model
Click here to download ENSG00000101367's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000101367Attention Deficit Disorder with Hyperactivity7E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity4E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity7E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity4E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity5E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity5E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity5E-623527680
ENSG00000101367Attention Deficit Disorder with Hyperactivity4E-623527680
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000101367rs60576512032822531AAttention deficit hyperactivity disorder (combined symptoms)23527680EFO_0003888
ENSG00000101367rs60576522032832003AAttention deficit hyperactivity disorder (combined symptoms)23527680EFO_0003888
ENSG00000101367rs72700852032849801AAttention deficit hyperactivity disorder (combined symptoms)23527680EFO_0003888
ENSG00000101367rs60576522032832003AAttention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms)23527680EFO_0003888
ENSG00000101367rs60576512032822531AAttention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms)23527680EFO_0003888
ENSG00000101367rs1409117382032849813GIron status biomarkers (transferrin saturation)28334935[0.31-0.71] unit decrease0.509EFO_0006333
ENSG00000101367rs8538542032832951TPolycystic ovary syndrome30566500[0.066-0.129] unit decrease0.0975EFO_0000660
ENSG00000101367rs793967402032839143?DNA methylation variation (age effect)30348214GO_0006306
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101367's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000101367MAPRE19953.608FBgn0027066Eb19754.417Drosophila_melanogaster
ENSG00000101367MAPRE110097.015ENSMUSG00000027479Mapre110097.015Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-TASProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0005515protein binding10226031.10644998.10773885.11943150.15631994.16455083.17563362.17828277.18477699.19543227.19553473.19632184.21646404.21820309.23874158.24997520.25225338.25416956.26242911.26485573.26496610.26638075.27107012.27173435.29162697.29997244.IPIFunction
GO:0005794Golgi apparatus-IEAComponent
GO:0005813centrosome21399614.IDAComponent
GO:0005815microtubule organizing center21873635.IBAComponent
GO:0005819spindle11943150.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule21873635.IBAComponent
GO:0005874microtubule10773885.IDAComponent
GO:0005881cytoplasmic microtubule21873635.IBAComponent
GO:0005925focal adhesion25490267.IDAComponent
GO:0008017microtubule binding21873635.IBAFunction
GO:0008022protein C-terminus binding7606712.TASFunction
GO:0008104protein localization26323690.TASProcess
GO:0008283cell proliferation7606712.TASProcess
GO:0010389regulation of G2/M transition of mitotic cell cycle-TASProcess
GO:0016477cell migration26242911.IMPProcess
GO:0019901protein kinase binding26323690.IPIFunction
GO:0030335positive regulation of cell migration-TASProcess
GO:0030981cortical microtubule cytoskeleton15631994.IDAComponent
GO:0031110regulation of microtubule polymerization or depolymerization21873635.IBAProcess
GO:0031115negative regulation of microtubule polymerization11943150.IDAProcess
GO:0031116positive regulation of microtubule polymerization29162697.IMPProcess
GO:0031253cell projection membrane-IEAComponent
GO:0035371microtubule plus-end21873635.IBAComponent
GO:0035372protein localization to microtubule21873635.IBAProcess
GO:0035372protein localization to microtubule19632184.21820309.IDAProcess
GO:0042802identical protein binding25416956.27107012.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0051010microtubule plus-end binding21873635.IBAFunction
GO:0051010microtubule plus-end binding15631994.19632184.IDAFunction
GO:0051225spindle assembly21873635.IBAProcess
GO:0051233spindle midzone21873635.IBAComponent
GO:0051301cell division-IEAProcess
GO:0097711ciliary basal body-plasma membrane docking-TASProcess
GO:1903033positive regulation of microtubule plus-end binding-IEAProcess
GO:1904825protein localization to microtubule plus-end21873635.IBAProcess
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