EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30106110Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF??B/Nrf2 signaling pathway.Mol Med Rep2018 OctWang Zdoi: 10.3892/mmr.2018.9388

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2025290576SilentnovelL641L0.25
BLCAchr2025279102Missense_MutationnovelE349K0.14
BLCAchr2025296496Missense_MutationnovelP836S0.41
BLCAchr2025277293Missense_MutationnovelE274D0.06
BLCAchr2025282102SilentnovelR491R0.38
BLCAchr2025281109Nonsense_MutationnovelS467*0.26
BLCAchr2025292566SilentnovelF710F0.16
BLCAchr2025296515Missense_Mutationrs200006792R842Q0.23
BLCAchr2025269147Nonsense_MutationnovelE122*0.46
BLCAchr2025284220SilentnovelL579L0.13
BLCAchr2025296379Missense_MutationnovelE797Q0.13
BLCAchr2025278424Missense_MutationnovelD321Y0.14
BLCAchr2025283235SilentnovelV526V0.3
BLCAchr2025248370Silentrs751691357L64L0.59
BRCAchr2025259234Splice_Regionnovel0.22
BRCAchr2025280402Missense_MutationnovelR410L0.1
BRCAchr2025292604Missense_MutationnovelD723G0.16
BRCAchr20252966333'UTRNA0.44
BRCAchr2025248370Silentrs751691357L64L0.25
BRCAchr2025259274Missense_Mutationrs769655708R94H0.37
BRCAchr2025284237Missense_MutationnovelV585D0.13
BRCAchr2025294206Silentrs146169925A742A0.31
BRCAchr2025271402Missense_Mutationrs767929147M148I0.34
BRCAchr2025276759Splice_SitenovelX258_splice0.15
BRCAchr2025292554SilentNAA706A0.27
BRCAchr2025292506Silentrs778626594I690I0.1
CESCchr2025248370SilentnovelL64L0.22
CESCchr2025259274Missense_Mutationrs769655708R94H0.33
CESCchr2025276700Missense_Mutationrs532747607V239I0.39
CESCchr2025278367Missense_MutationnovelA302T0.09
CESCchr2025280294Missense_Mutationrs540251614A374G0.13
CESCchr2025280366Missense_MutationNAP398R0.16
CESCchr2025274692Missense_MutationNAT210S0.47
CESCchr2025278345SilentnovelL294L0.42
CESCchr2025292500SilentnovelL688L0.37
COADchr2025294286Missense_MutationNAH769R0.54
COADchr2025278321Missense_MutationnovelF286L0.37
COADchr2025295643Silentrs767101832C784C0.36
COADchr2025292453Missense_Mutationrs200843501E673K0.19
COADchr2025259273Missense_Mutationrs200651502R94C0.28
COADchr2025288423Splice_Siters775018186X590_splice0.52
COADchr2025280983Missense_Mutationrs776622403R425H0.07
COADchr2025294207Missense_Mutationrs200955420V743M0.22
COADchr2025259274Missense_Mutationrs769655708R94H0.38
COADchr2025281015Missense_MutationNAD436N0.46
COADchr2025289918Intronnovel0.29
COADchr2025292464SilentnovelG676G0.45
COADchr2025295668Missense_Mutationrs202186644R793W0.29
COADchr2025277326Splice_Regionrs367923761N285N0.18
COADchr2025259307Missense_MutationnovelL105P0.09
COADchr2025271454Missense_MutationnovelI166V0.05
COADchr2025278411Missense_MutationnovelK316N0.16
COADchr2025279111Missense_MutationnovelR352W0.47
COADchr2025281098Silentrs201316067I463I0.32
COADchr20252481675'UTRnovel0.46
COADchr2025292579Missense_Mutationrs201026212R715W0.29
COADchr2025259306Missense_Mutationrs201324493L105F0.21
COADchr2025294266Silentrs199570469I762I0.32
COADchr2025292540Missense_MutationNAE702K0.11
COADchr2025281079Missense_Mutationrs200462235A457V0.08
COADchr2025278414Silentrs147846111F317F0.2
COADchr2025274603Silentrs35481467A180A0.22
COADchr2025292466Frame_Shift_DelNAT677Kfs*40.44
COADchr2025292553Missense_MutationNAA706V0.2
DLBCchr2025284150Missense_MutationnovelV556A0.29
ESCAchr2025280279Missense_Mutationrs201517237T369M0.2
ESCAchr2025296392Missense_MutationnovelK801R0.23
ESCAchr2025277288Missense_MutationnovelA273T0.4
ESCAchr2025248184SilentnovelA2A0.14
GBMchr2025271465Missense_MutationnovelQ169H0.12
GBMchr2025292453Missense_Mutationrs200843501E673K0.47
GBMchr2025274648SilentnovelP195P0.43
GBMchr2025278376Missense_MutationnovelL305F0.14
GBMchr2025278377Missense_MutationnovelL305R0.13
GBMchr2025292428Silentrs200674616S664S0.21
GBMchr2025294286Missense_MutationnovelH769P0.2
GBMchr2025259336Missense_MutationnovelQ115K0.2
HNSCchr2025288434Missense_MutationnovelR593T0.21
HNSCchr2025290616Missense_MutationnovelE655K0.21
HNSCchr20252965783'UTRnovel0.41
HNSCchr2025295624Missense_Mutationrs199953270Y778C0.21
HNSCchr2025259277Missense_Mutationrs370514593T95M0.24
HNSCchr2025282108SilentnovelL493L0.44
HNSCchr2025259237Missense_Mutationrs201508171R82C0.27
HNSCchr2025295635Frame_Shift_InsnovelM782Ifs*340.49
HNSCchr20252965393'UTRnovel0.23
KIRCchr2025278393SilentnovelR310R0.37
KIRCchr2025269180Missense_MutationNAG133W0.26
KIRPchr2025290602Missense_Mutationrs139162483R650H0.59
KIRPchr20252973743'UTRnovel0.6
KIRPchr2025248406SilentnovelY76Y0.14
LGGchr2025280956Missense_MutationNAA416G0.15
LGGchr2025274621Silentrs199968470Y186Y0.41
LGGchr2025278405Silentrs572592143S314S0.08
LGGchr2025281032SilentnovelN441N0.08
LIHCchr2025280952Missense_Mutationrs201813153V415M0.14
LUADchr2025248237Missense_MutationnovelA20V0.14
LUADchr2025276645Splice_SiteNAX221_splice0.21
LUADchr2025295643Silentrs767101832C784C0.13
LUADchr2025259236Splice_SitenovelX82_splice0.18
LUADchr2025280394Missense_MutationnovelI407M0.13
LUADchr2025283260Missense_Mutationrs758229367V535M0.5
LUSCchr2025279111SilentnovelR352R0.33
LUSCchr2025296405Missense_MutationnovelN805K0.28
LUSCchr2025276735SilentnovelP250P0.49
LUSCchr2025274601Missense_MutationNAA180S0.18
LUSCchr2025276723SilentnovelS246S0.32
LUSCchr2025279061Missense_MutationNAA335D0.59
MESOchr2025284230Missense_MutationnovelH583N0.34
OVchr2025292466Missense_MutationnovelT677R0.11
OVchr2025296435Frame_Shift_DelNAR816Gfs*840.18
OVchr2025259284Missense_MutationnovelQ97H0.07
OVchr2025281049Missense_MutationNAV447A0.23
OVchr2025280299Missense_MutationnovelT376A0.28
PAADchr2025274687SilentnovelE208E0.03
PAADchr2025296486SilentnovelD832D0.16
PRADchr2025277301Missense_MutationnovelS277F0.2
PRADchr2025278392Missense_Mutationrs761148570R310H0.3
PRADchr2025283242Missense_Mutationrs377297438E529K0.39
PRADchr2025295633Missense_MutationnovelY781C0.41
READchr2025290486Silentrs752184187A611A0.22
SARCchr2025271392Missense_Mutationrs773439527L145P0.26
SKCMchr2025296437Missense_MutationNAR816Q0.38
SKCMchr2025278444SilentnovelF327F0.26
SKCMchr2025248355SilentnovelT59T0.59
SKCMchr2025271390SilentNAF144F0.48
SKCMchr2025284131SilentNAL550L0.29
SKCMchr2025282066SilentNAK479K0.41
SKCMchr2025283184SilentnovelG509G0.31
SKCMchr2025281098Silentrs201316067I463I0.13
SKCMchr2025288434Missense_MutationnovelR593K0.07
SKCMchr2025292423Silentrs199748264L663L0.22
SKCMchr2025274694Missense_MutationnovelP211S0.24
SKCMchr2025277263Silentrs200881466I264I0.14
SKCMchr2025294266Silentrs199570469I762I0.19
SKCMchr2025296483Silentrs141315124S831S0.38
SKCMchr2025276698Missense_Mutationrs202165304T238I0.12
STADchr2025259274Missense_Mutationrs769655708R94H0.23
STADchr2025281110Splice_RegionNAS467S0.19
STADchr2025296497Missense_Mutationrs116595887P836L0.37
STADchr2025292527Silentrs776312433N697N0.07
STADchr2025296498Silentrs200465936P836P0.13
STADchr2025278360Silentrs777454522F299F0.37
STADchr20252965823'UTRnovel0.23
STADchr2025278391Missense_Mutationrs773607885R310C0.14
STADchr2025292521SilentnovelG695G0.17
STADchr2025271394Missense_MutationNAD146N0.24
STADchr2025295642Missense_MutationNAC784Y0.14
STADchr2025277311Silentrs749516060L280L0.17
STADchr2025279090Missense_MutationNAL345I0.29
STADchr2025296398Missense_MutationnovelI803T0.46
STADchr20252965753'UTRnovel0.12
STADchr2025280957Silentrs777782398A416A0.07
STADchr2025294262Missense_Mutationrs767386910D761G0.13
STADchr2025279087Missense_Mutationrs199970228A344T0.11
STADchr2025292593Silentrs199809129V719V0.24
UCECchr2025288471Missense_MutationNAM605I0.34
UCECchr2025277323SilentnovelD284D0.14
UCECchr2025284181SilentnovelV566V0.18
UCECchr2025274692Frame_Shift_DelnovelD212Tfs*30.29
UCECchr2025292428Silentrs200674616S664S0.11
UCECchr2025274687Missense_MutationNAE208D0.39
UCECchr2025277315Missense_MutationNAP282S0.47
UCECchr2025295651Missense_MutationnovelQ787R0.07
UCECchr2025281071SilentNAN454N0.18
UCECchr2025279111Missense_MutationnovelR352W0.25
UCECchr2025295621Missense_MutationnovelD777G0.45
UCECchr2025282063Missense_MutationNAE478D0.26
UCECchr2025292518Silentrs199972111D694D0.29
UCECchr2025284236Missense_Mutationrs763681247V585I0.24
UCECchr2025248402Missense_MutationnovelY75C0.25
UCECchr2025274667Missense_MutationnovelH202Y0.29
UCECchr2025296426Missense_MutationNAF812L0.41
UCECchr2025274617Missense_Mutationrs747769681R185H0.33
UCECchr2025294266Silentrs199570469I762I0.13
UCECchr20252966303'UTRnovel0.24
UCECchr2025296436SilentnovelR816R0.27
UCECchr2025294228Frame_Shift_DelNAS752Lfs*120.14
UCECchr2025278391Missense_Mutationrs773607885R310C0.36
UCECchr2025292434Silentrs768358990Q666Q0.46
UCECchr2025294207Missense_Mutationrs200955420V743M0.39
UCECchr2025274696Silentrs199794539P211P0.35
UCECchr2025284186Missense_MutationnovelV568A0.1
UCECchr2025280358SilentnovelK395K0.34
UCECchr2025281099Missense_Mutationrs201900026V464M0.11
UCECchr2025284154Missense_MutationnovelK557N0.57
UCECchr2025296497Missense_Mutationrs116595887P836L0.53
UCECchr2025296451Missense_MutationNAY821D0.2
UCECchr2025271424Missense_MutationnovelY156H0.35
UCECchr2025274654SilentnovelY197Y0.07
UCECchr2025290539Missense_Mutationrs752703479D629G0.35
UCECchr2025296499Frame_Shift_DelNAN839Tfs*610.37
UCECchr2025290537Silentrs201261056G628G0.34
UCECchr2025280369Missense_MutationNAR399P0.12
UCECchr2025292413Silentrs143059247P659P0.36
UCECchr2025292540Missense_MutationNAE702K0.41
UCECchr2025259290Silentrs780877333T99T0.31
UCECchr2025271445Nonsense_MutationnovelE163*0.25
UCECchr2025284136Missense_Mutationrs146700755E551D0.43
UCECchr2025294221SilentNAS747S0.42
UCECchr2025259278Silentrs201935645T95T0.41
UCECchr2025281080Silentrs201940866A457A0.46
UCECchr2025279077SilentnovelD340D0.3
UCECchr2025274617Missense_MutationnovelR185L0.11
UCECchr2025281099Missense_Mutationrs201900026V464M0.1
UCECchr2025274616Missense_Mutationrs201326100R185C0.16
UCECchr2025248263Frame_Shift_InsnovelK30Efs*820.07
UCECchr2025282092Frame_Shift_DelNAR490Afs*240.44
UCECchr20252966453'UTRnovel0.56
UCECchr2025259278Silentrs201935645T95T0.47
UCECchr2025284186Missense_MutationnovelV568A0.14
UCECchr2025274700Missense_Mutationrs200712486G213S0.25
UCECchr2025280264Splice_SiteNAX365_splice0.29
UCECchr2025271429SilentnovelG157G0.22
UCECchr2025280958Missense_Mutationrs143661747A417T0.35
UCECchr2025284214SilentnovelQ577Q0.28
UCECchr2025248218Missense_MutationnovelI14V0.35
UCECchr2025276699Silentrs200350706T238T0.5
UCECchr2025279111Missense_MutationnovelR352W0.46
UCECchr2025290490Missense_MutationnovelG613S0.35
UCECchr2025259294Missense_MutationnovelV101M0.29
UCECchr2025278339SilentnovelL292L0.36
UCSchr2025296483Silentrs141315124S831S0.56

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LUADAMP0.27710.19771

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.029

Kaplan-Meier Survival Analysis

MESO0.0054

Kaplan-Meier Survival Analysis

ACC0.04

Kaplan-Meier Survival Analysis

LUSC0.00012

Kaplan-Meier Survival Analysis

PAAD0.001

Kaplan-Meier Survival Analysis

BLCA0.0035

Kaplan-Meier Survival Analysis

LIHC0.0017

Kaplan-Meier Survival Analysis

LGG0.0025

Kaplan-Meier Survival Analysis

CHOL0.033

Kaplan-Meier Survival Analysis

LUAD0.0047

Kaplan-Meier Survival Analysis

UVM0.018

Kaplan-Meier Survival Analysis

OV0.004

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000100994 (Gene tree)
Gene ID
5834
Gene Symbol
PYGB
Alias
N
Full Name
glycogen phosphorylase B
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
49,946 bases
Position
chr20:25,248,069-25,298,014
Accession
9723
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000428458PYGB-202734-ENSP00000395451245 (aa)-H0Y4Z6
ENST00000216962PYGB-2014134-ENSP00000216962843 (aa)-P11216
ENST00000471359PYGB-203726--- (aa)--
Gene Model
Click here to download ENSG00000100994's gene model file
Pathways
Pathway IDPathway NameSource
hsa00500Starch and sucrose metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04217NecroptosisKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04922Glucagon signaling pathwayKEGG
hsa04931Insulin resistanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000100994Calcium5E-624068962
ENSG00000100994dimethylarginine8E-624159190
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000100994rs22815582025259553TCalcium levels24068962[0.0091-0.0209] unit increase0.015EFO_0004838
ENSG00000100994rs1396729652025286264AAsymmetrical dimethylarginine levels24159190[0.37-0.94] unit increase0.654EFO_0006522|EFO_0005418
ENSG00000100994rs22815582025259553?Peripheral arterial disease (traffic-related air pollution interaction)27082954[3.88-5.4]4.64EFO_0004265|EFO_0007908
ENSG00000100994rs735983732025294985CTelomere length30185882[0.133-0.311] unit decrease0.222EFO_0004505
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100994's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000100994PYGB9972.434FBgn0004507GlyP9972.434Drosophila_melanogaster
ENSG00000100994PYGB9981.883ENSG00000100504PYGL9981.883Homo_sapiens
ENSG00000100994PYGB10095.611ENSMUSG00000033059Pygb10095.611Mus_musculus
ENSG00000100994PYGB9983.671ENSMUSG00000032648Pygm9983.671Mus_musculus
ENSG00000100994PYGB9548.931YPR160W9248.456Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding25416956.25910212.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm10638593.IDAComponent
GO:0005980glycogen catabolic process21873635.IBAProcess
GO:0005980glycogen catabolic process3346228.NASProcess
GO:0008184glycogen phosphorylase activity21873635.IBAFunction
GO:0008184glycogen phosphorylase activity3346228.NASFunction
GO:0016020membrane19946888.HDAComponent
GO:0030170pyridoxal phosphate binding21873635.IBAFunction
GO:0035578azurophil granule lumen-TASComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0070062extracellular exosome23533145.HDAComponent
GO:0102250linear malto-oligosaccharide phosphorylase activity-IEAFunction
GO:0102499SHG alpha-glucan phosphorylase activity-IEAFunction
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