EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25672588APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.Cancer Res Treat2015 OctShin JHdoi: 10.4143/crt.2014.074
27057081Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker.Dis Markers2016Choi Sdoi: 10.1155/2016/7276502
18061304Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.Lung Cancer2008 MayYoo DG-
17974506Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.DNA Repair (Amst)2008 Feb 1Fishel ML-
28181292Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.Environ Mol Mutagen2017 MarIlluzzi JLdoi: 10.1002/em.22074
18809583Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.Mol Cell Biol2008 DecChattopadhyay Rdoi: 10.1128/MCB.00244-08
26981776Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.Oncotarget2016 Apr 19Bhakat KKdoi: 10.18632/oncotarget.8026.
24329908Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.Cancer Sci2014 FebRen Tdoi: 10.1111/cas.12334
16481390Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).Mol Pharmacol2006 MayLam W-
20498636Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation.Oncogene2010 Jul 29Wu HHdoi: 10.1038/onc.2010.178
18627350Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.Antioxid Redox Signal2008 NovLuo Mdoi: 10.1089/ars.2008.2120.
14599768APE/Ref-1 and the mammalian response to genotoxic stress.Toxicology2003 Nov 15Fritz G-
28986522Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.Nat Commun2017 Oct 6Antoniali Gdoi: 10.1038/s41467-017-00842-8.
27655688Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.Oncotarget2016 Nov 15Sengupta Sdoi: 10.18632/oncotarget.12113.
25945024Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis.World J Gastroenterol2015 Apr 28Dai ZJdoi: 10.3748/wjg.v21.i16.5081.
20354815Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China.Med Oncol2011 SepDeng Qdoi: 10.1007/s12032-010-9507-2
23749940The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk.Anticancer Res2013 JunChen WC-
26314200The association of ApE1 -656T>G and 1349T>G polymorphisms with breast cancer susceptibility in northern Iran.Cell Mol Biol (Noisy-le-grand)2015 Aug 28Mashayekhi F-
23065211Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.Mol Biol Rep2012 DecWei Wdoi: 10.1007/s11033-012-2035-8
26045303Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk.Carcinogenesis2015 SepSevilya Zdoi: 10.1093/carcin/bgv082
22176746The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies.BMC Cancer2011 Dec 18Zhou Bdoi: 10.1186/1471-2407-11-521.
27553367Silencing of Apurinic/Apyrimidinic Endonuclease 1 Inhibits the Growth and Migration in Ovarian Cancer Cell via Activator-Protein-1 Signaling.Gynecol Obstet Invest2017Kong Qdoi: 10.1159/000447261
23831574Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.Oncogene2014 May 29Vascotto Cdoi: 10.1038/onc.2013.251
19041121Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India.Urology2009 MarGangwar Rdoi: 10.1016/j.urology.2008.09.043
26255264The association between 1349T>G polymorphism of ApE1 gene and the risk of prostate cancer in northern Iran.Cell Mol Biol (Noisy-le-grand)2015 Aug 5Pournourali M-
24257553Apurinic/apyrimidinic endonuclease 1 polymorphisms are associated with ovarian cancer susceptibility in a Chinese population.Int J Gynecol Cancer2013 OctZhang Xdoi: 10.1097/IGC.0b013e3182a33f07.
25033834APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions.Exp Mol Med2014 Jul 18Thakur Sdoi: 10.1038/emm.2014.42.
23038158The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.J Epidemiol2012Lin CHdoi: 10.2188/jea.JE20120048
24914806Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.PLoS One2014 Jun 10Woo Jdoi: 10.1371/journal.pone.0099528
20218899Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.DNA Cell Biol2010 JunWang Mdoi: 10.1089/dna.2009.0969.
15316562Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.Br J Cancer2004 Sep 13Lau JP-
23430444Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population.Med Oncol2013 JunLi Ydoi: 10.1007/s12032-013-0505-z
19292061[The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer].Sichuan Da Xue Xue Bao Yi Xue Ban2009 JanQing Y-
26125438Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation.Oncotarget2015 Sep 15Lee YR-
17332344Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.Cancer Res2007 Mar 1Raffoul JJ-
25107571Predictive value of APE1, BRCA1, ERCC1 and TUBB3 expression in patients with advanced non-small cell lung cancer (NSCLC) receiving first-line platinum-paclitaxel chemotherapy.Cancer Chemother Pharmacol2014 OctLi Zdoi: 10.1007/s00280-014-2562-1
26359670Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry.Biochemistry2015 Sep 29Coskun Edoi: 10.1021/acs.biochem.5b00928
23408843Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.Mutagenesis2013 MarMahjabeen Idoi: 10.1093/mutage/ges074.
23094050APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.PLoS One2012Cardoso AAdoi: 10.1371/journal.pone.0047462
26081414Ape1 regulates WNT/β-catenin signaling through its redox functional domain in pancreatic cancer cells.Int J Oncol2015 AugJiang Sdoi: 10.3892/ijo.2015.3048
23272074Lack of an association between two BER gene polymorphisms and breast cancer risk: a meta-analysis.PLoS One2012Wu Bdoi: 10.1371/journal.pone.0050857
26257461Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk.Dis Markers2015AlMutairi Fdoi: 10.1155/2015/869512
21132382APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis.Mol Biol Rep2011 OctJi YNdoi: 10.1007/s11033-010-0584-2
17949784Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.Hum Pathol2008 FebNoike T-
24254302The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis.Tumour Biol2014 MarShen Edoi: 10.1007/s13277-013-1334-6
21037106Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.Cancer Epidemiol Biomarkers Prev2010 DecBrevik Adoi: 10.1158/1055-9965.EPI-10-0606
24606430Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese population.Asian Pac J Cancer Prev2014Luo H-
19787261Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor.Int J Oncol2009 NovZhang Y-
25023401Association between APE1 T1349G polymorphism and prostate cancer risk: evidence from a meta-analysis.Tumour Biol2014 OctLi Xdoi: 10.1007/s13277-014-2115-6
25733810Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer.Drug Des Devel Ther2015 Feb 16Qing Ydoi: 10.2147/DDDT.S75152
24414702The association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility: a meta-analysis based on case-control studies.Tumour Biol2014 MayZhao Zdoi: 10.1007/s13277-014-1618-5
25344644Susceptibility and REF1 gene polymorphism towards colorectal cancer.Cell Biochem Biophys2015 MarYang Sdoi: 10.1007/s12013-014-0296-7.
21615620A genetic variation in APE1 is associated with gastric cancer survival in a Chinese population.Cancer Sci2011 JulZhao Qdoi: 10.1111/j.1349-7006.2011.01959.x
23994194A genetic variant in the promoter of APE1 gene (-656 T>G) is associated with breast cancer risk and progression in a Chinese population.Gene2013 Nov 15Kang Hdoi: 10.1016/j.gene.2013.08.052
23874853Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.PLoS One2013 Jul 11Pan Hdoi: 10.1371/journal.pone.0069018
20852942Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.Mol Biol Rep2011 MarKuasne Hdoi: 10.1007/s11033-010-0267-z
22493391Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma.Anticancer Res2012 AprShukla VK-
25024628APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.World J Gastroenterol2014 Jul 14Zhang SHdoi: 10.3748/wjg.v20.i26.8700.
19528510Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking.Anticancer Res2009 JunAgahan B-
23268706Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro.Cancer Biother Radiopharm2013 MarChen Sdoi: 10.1089/cbr.2012.1266
24884729A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy.Br J Radiol2014 AugLi Hdoi: 10.1259/bjr.20140093
18503157Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.Cancer Biomark2008Shekari M-
24893568Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis.Diagn Pathol2014 Jun 3Peng Qdoi: 10.1186/1746-1596-9-108.
19541747Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.FASEB J2009 OctLu Jdoi: 10.1096/fj.09-136549
21722819Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population.Arch Med Res2011 AprLi Zdoi: 10.1016/j.arcmed.2011.04.005.
21198260APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.Asian Pac J Cancer Prev2010Osawa K-
27802207APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target.Cancer Biomark2016 Sep 26Wen X-
24523018APE1 Asp148Glu polymorphism and lung cancer susceptibility.Tumour Biol2014 JunCai Ldoi: 10.1007/s13277-014-1681-y
20919954Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.Cancer Invest2010 NovJiang Ydoi: 10.3109/07357907.2010.512816.
19762350The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies.Mutagenesis2009 NovGu Ddoi: 10.1093/mutage/gep036
26373042Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).J Nanosci Nanotechnol2015 JulElingarami S-
18823566Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.J Exp Clin Cancer Res2008 Sep 30Kasahara Mdoi: 10.1186/1756-9966-27-49.
19124501A polymorphism in the APE1 gene promoter is associated with lung cancer risk.Cancer Epidemiol Biomarkers Prev2009 JanLo YLdoi: 10.1158/1055-9965.EPI-08-0749.
24705777Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer.Tumour Biol2014 JulJin Fdoi: 10.1007/s13277-014-1829-9
17034901Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.Lung Cancer2006 DecRyk C-
19242824Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India.Med Oncol2010 JunGangawar Rdoi: 10.1007/s12032-009-9187-y
24349526APEX nuclease (multifunctional DNA repair enzyme) 1 gene Asp148Glu polymorphism and cancer risk: a meta-analysis involving 58 articles and 48903 participants.PLoS One2013 Dec 12Hu Ddoi: 10.1371/journal.pone.0083527
19097035The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis.J Cell Physiol2009 AprZou GMdoi: 10.1002/jcp.21666.
25234162The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case-control studies.Mol Genet Genomics2015 FebZhou Xdoi: 10.1007/s00438-014-0916-3
22205985The DNA repair gene APE1 T1349G polymorphism and risk of gastric cancer in a Chinese population.PLoS One2011Gu Ddoi: 10.1371/journal.pone.0028971
17855454Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.Hum Mol Genet2007 Oct 1Matakidou A-
23110144Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.PLoS One2012Dorjsuren Ddoi: 10.1371/journal.pone.0047974
19188437Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.Mol Cell Biol2009 AprKim MHdoi: 10.1128/MCB.01484-08
17922186Polymorphisms in three base excision repair genes and breast cancer risk in Thai women.Breast Cancer Res Treat2008 SepSangrajrang S-
26292623Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.Med Sci Monit2015 Aug 21Li Hdoi: 10.12659/MSM.893954.
24076439Impact of genetic polymorphisms in base excision repair genes on the risk of breast cancer in a Korean population.Gene2013 Dec 15Kim KYdoi: 10.1016/j.gene.2013.09.069
23776569Functional assessment of population and tumor-associated APE1 protein variants.PLoS One2013 Jun 11Illuzzi JLdoi: 10.1371/journal.pone.0065922
18669164Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women.Oncol Res2008Mitra AK-
23479135Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer.Cancer Chemother Pharmacol2013 MayZhao Wdoi: 10.1007/s00280-013-2127-8
20530453Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer.Anticancer Res2010 AprCanbay E-
21479902Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer.Med Oncol2012 JunSheng Qdoi: 10.1007/s12032-011-9931-y
15816625Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.Anticancer Res2005 Jan-FebShen M-
23143180APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis.Mol Biol Rep2013 JanLiu Cdoi: 10.1007/s11033-012-2046-5
25156607The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese.Mol Carcinog2015 JunLi Xdoi: 10.1002/mc.22195
23871947Genetic variant in APE1 gene promoter contributes to cervical cancer risk.Am J Obstet Gynecol2013 OctWang Mdoi: 10.1016/j.ajog.2013.07.010
21561390Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.Curr Med Res Opin2011 JulCanbay Edoi: 10.1185/03007995.2011.573544
24310503The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis.Tumour Biol2014 AprChen Wdoi: 10.1007/s13277-013-1474-8
26146106Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population.Pol Przegl Chir2015 MarKabzi??ski Jdoi: 10.1515/pjs-2015-0030.
19324449APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells.Lung Cancer2009 DecWang Ddoi: 10.1016/j.lungcan.2009.02.019
25292033Germline variations of apurinic/apyrimidinic endonuclease 1 (APEX1) detected in female breast cancer patients.Asian Pac J Cancer Prev2014Ali K-
16221808Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.Am J Epidemiol2005 Nov 15Hung RJ-
24284961Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.Am J Physiol Gastrointest Liver Physiol2014 FebNagoya Hdoi: 10.1152/ajpgi.00057.2013
18357393Prevalence of BER gene polymorphisms in sporadic breast cancer.Oncol Rep2008 AprAli MF-
27539671Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls.Breast Cancer2017 MayHsieh WCdoi: 10.1007/s12282-016-0719-y
29064327The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib.Tumour Biol2017 OctChen Tdoi: 10.1177/1010428317713390.
27248666Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.Oncotarget2016 Aug 9Chen Ydoi: 10.18632/oncotarget.9693.
27050370APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.Oncotarget2016 May 3Lirussi Ldoi: 10.18632/oncotarget.8477.
27388124Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.Sci Rep2016 Jul 8Nassour Hdoi: 10.1038/srep29389.
28887667APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells.Mol Cell Biochem2018 AprThakur Sdoi: 10.1007/s11010-017-3186-7
30703296 Workers.Radiats Biol Radioecol2016 JulRusinova GG-
29720094Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China.BMC Med Genet2018 May 2Wang Tdoi: 10.1186/s12881-018-0578-9.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1420457398Missense_MutationNAD283H0.46
BLCAchr1420457042Missense_Mutationrs778999137S164L0.41
BRCAchr14204575113'UTRrs7741683470.34
BRCAchr1420455930SilentNAK25K0.15
BRCAchr1420457104Missense_Mutationrs765234188R185W0.24
BRCAchr1420455659Missense_MutationNAG5A0.29
BRCAchr1420457416Missense_MutationNAH289Y0.38
CESCchr1420455665Missense_MutationNAK7R0.05
CESCchr1420457319SilentNAL256L0.29
CESCchr14204555975'UTRnovel0.15
CESCchr1420457392Missense_Mutationrs751223947R281C0.37
COADchr1420457213Missense_Mutationrs778698391R221H0.24
COADchr1420457364Missense_MutationnovelM271I0.11
COADchr14204575843'UTRnovel0.32
COADchr1420457240Missense_MutationNAA230D0.29
COADchr1420456810Missense_MutationNAG130D0.11Exo_endo_phos
COADchr1420457239Missense_MutationNAA230T0.22
ESCAchr1420455530Intronnovel0.27
ESCAchr1420457044Missense_MutationnovelF165V0.42
GBMchr1420457411Frame_Shift_InsnovelL287Ffs*110.06
GBMchr1420456820Frame_Shift_InsnovelL134Sfs*160.24Exo_endo_phos
LGGchr1420457285Missense_MutationnovelQ245R0.34
LGGchr1420457418Missense_MutationnovelH289Q0.72
LIHCchr1420457210Missense_MutationnovelL220P0.26
LIHCchr1420457389Missense_MutationnovelW280R0.34
LUADchr1420456765Missense_MutationnovelS115F0.18Exo_endo_phos
LUADchr1420457164Frame_Shift_InsnovelV206Cfs*110.16
LUADchr14204556115'UTRnovel0.18
LUSCchr1420455526Intronnovel0.63
LUSCchr1420455936SilentnovelK27K0.26
LUSCchr1420455937Missense_MutationnovelT28S0.27
OVchr1420457233Nonsense_MutationnovelK228*0.05
OVchr1420457238SilentnovelN229N0.1
OVchr14204575723'UTRnovel0.11
OVchr1420457129Missense_Mutationrs367614890R193H0.38
READchr1420457128Missense_Mutationrs778301776R193C0.51
READchr1420457372Missense_Mutationrs374977590R274Q0.42
SARCchr1420455958Frame_Shift_Delrs764279183K35Rfs*110.48
SKCMchr1420455691Missense_MutationNAE16K0.23
SKCMchr1420455538Intronnovel0.57
SKCMchr14204576373'UTRnovel0.26
STADchr1420456855Missense_MutationnovelG145D0.63
STADchr1420456726Missense_MutationNAN102I0.08Exo_endo_phos
STADchr1420455653Missense_MutationNAK3R0.1
STADchr1420455654SilentNAK3K0.26
UCECchr1420456671Missense_MutationnovelV84I0.13Exo_endo_phos
UCECchr1420456790SilentnovelS123S0.15
UCECchr14204576653'UTRnovel0.45
UCECchr1420455921SilentNAE22E0.19
UCECchr1420456811Silentrs776338830G130G0.25
UCECchr1420457070SilentNAP173P0.15
UCECchr1420457060Missense_MutationnovelA170V0.22
UCECchr14204575913'UTRnovel0.3
UCECchr1420457219Missense_MutationnovelP223L0.59
UCECchr14204576943'UTRrs31896620.42
UCECchr1420457042Missense_Mutationrs778999137S164L0.42
UCECchr1420457129Missense_Mutationrs367614890R193H0.13
UCECchr1420457384Missense_MutationnovelV278D0.41
UCECchr1420457213Missense_Mutationrs778698391R221H0.27
UCSchr1420457493SilentnovelL314L0.07
UCSchr1420457129Missense_Mutationrs367614890R193H0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.14440.19769
CHOLDEL0.36110.00040262
DLBCDEL0.04170.18166
HNSCDEL0.10540.0025503
KIRPDEL0.16320.085174
LUSCDEL0.25550.0082553
PAADDEL0.0870.11332
READDEL0.36970.0043084
THCADEL0.0020.221
UCECDEL0.09465.8317e-06
UCSDEL0.42860.19877
UVMDEL0.01250.22482

Survival Analysis
CancerP-value Q-value
KIRC0.0017

Kaplan-Meier Survival Analysis

SARC0.0082

Kaplan-Meier Survival Analysis

MESO0.015

Kaplan-Meier Survival Analysis

ACC0.0028

Kaplan-Meier Survival Analysis

HNSC0.04

Kaplan-Meier Survival Analysis

LUSC0.022

Kaplan-Meier Survival Analysis

TGCT0.05

Kaplan-Meier Survival Analysis

COAD0.05

Kaplan-Meier Survival Analysis

GBM0.028

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.0007

Kaplan-Meier Survival Analysis

OV0.0032

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000100823 (Gene tree)
Gene ID
328
Gene Symbol
APEX1
Alias
APE|REF1|HAP1|APX|APEN|REF-1|APE-1|APEX
Full Name
apurinic/apyrimidinic endodeoxyribonuclease 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
2,642 bases
Position
chr14:20,455,131-20,457,772
Accession
587
RBP type
canonical RBP
Summary
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000216714Exo_endo_phosPF03372.233.4e-2111
ENSP00000381111Exo_endo_phosPF03372.233.4e-2111
ENSP00000451979Exo_endo_phosPF03372.233.4e-2111
ENSP00000451327Exo_endo_phosPF03372.237.6e-1611
ENSP00000452460Exo_endo_phosPF03372.231.2e-1411
ENSP00000416414Exo_endo_phosPF03372.231e-1311
ENSP00000451060Exo_endo_phosPF03372.231.3e-0711
ENSP00000452418Exo_endo_phosPF03372.231.6e-0711
ENSP00000451170Exo_endo_phosPF03372.232e-0711
ENSP00000452137Exo_endo_phosPF03372.237.5e-0711
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21762700Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.J Mol Biol2011 Sep 2Kim WCdoi: 10.1016/j.jmb.2011.06.050
19188445APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Mol Cell Biol2009 AprVascotto Cdoi: 10.1128/MCB.01337-08
20032196Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.Mol Endocrinol2010 FebRay Sdoi: 10.1210/me.2009-0319
17114472Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.J Immunol2006 Dec 1O'Hara AM-
20699270Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Nucleic Acids Res2010 DecFantini Ddoi: 10.1093/nar/gkq691
23544830Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).Biochem J2013 Jun 15Poletto Mdoi: 10.1042/BJ20121277.
26432868 and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.Am J Physiol Lung Cell Mol Physiol2015 Dec 1Pastukh Vdoi: 10.1152/ajplung.00236.2015
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000556296APEX1-213571--- (aa)--
ENST00000554813APEX1-208654--- (aa)--
ENST00000398030APEX1-2021387-ENSP00000381111318 (aa)-P27695
ENST00000557159APEX1-2161803--- (aa)--
ENST00000553555APEX1-2051603--- (aa)--
ENST00000438886APEX1-203451-ENSP00000416414150 (aa)-H7C4A8
ENST00000557344APEX1-218671-ENSP00000452137146 (aa)-A0A0C4DGK8
ENST00000557365APEX1-219831--- (aa)--
ENST00000557150APEX1-215740-ENSP00000452418162 (aa)-G3V5M0
ENST00000555306APEX1-209898--- (aa)--
ENST00000557181APEX1-217566-ENSP00000452304107 (aa)-G3V5D9
ENST00000556054APEX1-212773-ENSP00000451170174 (aa)-G3V3C7
ENST00000553368APEX1-204304-ENSP0000045149141 (aa)-G3V3Y6
ENST00000216714APEX1-2011484-ENSP00000216714318 (aa)-P27695
ENST00000554325APEX1-207568-ENSP0000045060449 (aa)-G3V2D9
ENST00000555839APEX1-211952-ENSP00000452460242 (aa)-G3V5Q1
ENST00000553681APEX1-206899-ENSP00000451327263 (aa)-G3V3M6
ENST00000557592APEX1-220640-ENSP00000451060172 (aa)-G3V359
ENST00000555414APEX1-2101437-ENSP00000451979318 (aa)-P27695
ENST00000557054APEX1-214888-ENSP0000045221214 (aa)-G3V574
Gene Model
Click here to download ENSG00000100823's gene model file
Pathways
Pathway IDPathway NameSource
hsa03410Base excision repairKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100823's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000100823APEX18869.534ENSAPOG00000017002apex19169.534Acanthochromis_polyacanthus
ENSG00000100823APEX110095.597ENSAMEG00000005418APEX110095.597Ailuropoda_melanoleuca
ENSG00000100823APEX19959.649ENSACIG00000010653apex19471.326Amphilophus_citrinellus
ENSG00000100823APEX18869.534ENSAOCG00000009649apex19069.534Amphiprion_ocellaris
ENSG00000100823APEX18869.534ENSAPEG00000021453apex19069.534Amphiprion_percula
ENSG00000100823APEX19959.064ENSATEG00000002883apex19766.772Anabas_testudineus
ENSG00000100823APEX110069.255ENSACAG00000008099APEX110069.255Anolis_carolinensis
ENSG00000100823APEX110097.799ENSANAG00000030117APEX110097.799Aotus_nancymaae
ENSG00000100823APEX19959.064ENSACLG00000018441apex19966.038Astatotilapia_calliptera
ENSG00000100823APEX110065.625ENSAMXG00000034699apex110065.625Astyanax_mexicanus
ENSG00000100823APEX110093.711ENSBTAG00000002745APEX110093.711Bos_taurus
ENSG00000100823APEX19240.741WBGene00001372exo-38845.312Caenorhabditis_elegans
ENSG00000100823APEX110098.428ENSCJAG00000009726APEX110098.428Callithrix_jacchus
ENSG00000100823APEX110095.283ENSCAFG00000032033APEX110095.283Canis_familiaris
ENSG00000100823APEX110091.781ENSCAFG00020023002-9691.860Canis_lupus_dingo
ENSG00000100823APEX110095.283ENSCAFG00020014377-10095.283Canis_lupus_dingo
ENSG00000100823APEX19780.469ENSCHIG00000014537-9974.679Capra_hircus
ENSG00000100823APEX110093.082ENSCHIG00000007298-10093.082Capra_hircus
ENSG00000100823APEX110094.654ENSTSYG00000034813APEX110094.654Carlito_syrichta
ENSG00000100823APEX18588.561ENSCAPG00000016235APEX19197.458Cavia_aperea
ENSG00000100823APEX110094.340ENSCPOG00000030909APEX110094.340Cavia_porcellus
ENSG00000100823APEX19594.872ENSCCAG00000031931-10084.906Cebus_capucinus
ENSG00000100823APEX110098.428ENSCCAG00000033056-10098.428Cebus_capucinus
ENSG00000100823APEX110098.428ENSCATG00000015580APEX110098.428Cercocebus_atys
ENSG00000100823APEX110094.654ENSCLAG00000001002APEX110094.654Chinchilla_lanigera
ENSG00000100823APEX110098.131ENSCSAG00000016670-10098.113Chlorocebus_sabaeus
ENSG00000100823APEX110098.131ENSCSAG00000016685-10098.113Chlorocebus_sabaeus
ENSG00000100823APEX110072.100ENSCPBG00000009567APEX110072.100Chrysemys_picta_bellii
ENSG00000100823APEX19353.465ENSCING00000008137-8458.113Ciona_intestinalis
ENSG00000100823APEX18351.698ENSCSAVG00000007144-10052.510Ciona_savignyi
ENSG00000100823APEX110098.428ENSCANG00000030726APEX110098.428Colobus_angolensis_palliatus
ENSG00000100823APEX19993.529ENSCGRG00001017046Apex110092.138Cricetulus_griseus_chok1gshd
ENSG00000100823APEX19993.529ENSCGRG00000008984Apex110092.138Cricetulus_griseus_crigri
ENSG00000100823APEX19965.094ENSCSEG00000017499apex19965.094Cynoglossus_semilaevis
ENSG00000100823APEX18870.968ENSCVAG00000022075apex19965.823Cyprinodon_variegatus
ENSG00000100823APEX110066.038ENSDARG00000045843apex110066.038Danio_rerio
ENSG00000100823APEX19992.353ENSDNOG00000042234APEX19589.308Dasypus_novemcinctus
ENSG00000100823APEX110094.340ENSDORG00000001616Apex110094.340Dipodomys_ordii
ENSG00000100823APEX110093.711ENSETEG00000004855-10093.711Echinops_telfairi
ENSG00000100823APEX17564.854ENSEBUG00000000622-9264.854Eptatretus_burgeri
ENSG00000100823APEX110096.226ENSEASG00005017489APEX17496.226Equus_asinus_asinus
ENSG00000100823APEX110096.226ENSECAG00000022325APEX18296.226Equus_caballus
ENSG00000100823APEX19892.453ENSEEUG00000012569APEX110093.750Erinaceus_europaeus
ENSG00000100823APEX110065.517ENSELUG00000021706apex110065.938Esox_lucius
ENSG00000100823APEX110096.226ENSFCAG00000030869APEX110096.226Felis_catus
ENSG00000100823APEX110093.396ENSFDAG00000006120APEX110093.396Fukomys_damarensis
ENSG00000100823APEX19967.405ENSFHEG00000009031apex18367.405Fundulus_heteroclitus
ENSG00000100823APEX19961.635ENSGMOG00000007943apex19961.442Gadus_morhua
ENSG00000100823APEX19967.089ENSGAFG00000005311apex19967.089Gambusia_affinis
ENSG00000100823APEX19964.873ENSGACG00000019497apex19969.173Gasterosteus_aculeatus
ENSG00000100823APEX110071.787ENSGAGG00000014999APEX110071.787Gopherus_agassizii
ENSG00000100823APEX110099.065ENSGGOG00000002128APEX110099.057Gorilla_gorilla
ENSG00000100823APEX19966.139ENSHBUG00000005894apex19966.456Haplochromis_burtoni
ENSG00000100823APEX110094.340ENSHGLG00000002848APEX110094.340Heterocephalus_glaber_female
ENSG00000100823APEX110094.340ENSHGLG00100017878APEX110094.340Heterocephalus_glaber_male
ENSG00000100823APEX19966.144ENSHCOG00000009961apex19965.723Hippocampus_comes
ENSG00000100823APEX110067.712ENSIPUG00000005799apex110067.398Ictalurus_punctatus
ENSG00000100823APEX110093.711ENSSTOG00000010096APEX110093.711Ictidomys_tridecemlineatus
ENSG00000100823APEX110094.025ENSJJAG00000012067-10094.025Jaculus_jaculus
ENSG00000100823APEX110084.591ENSJJAG00000003660-10084.591Jaculus_jaculus
ENSG00000100823APEX19982.803ENSJJAG00000020465-9684.564Jaculus_jaculus
ENSG00000100823APEX18871.326ENSKMAG00000021171apex19966.139Kryptolebias_marmoratus
ENSG00000100823APEX18868.459ENSLBEG00000010248apex19964.217Labrus_bergylta
ENSG00000100823APEX110067.601ENSLACG00000008617APEX110066.981Latimeria_chalumnae
ENSG00000100823APEX110066.770ENSLOCG00000015516apex19966.355Lepisosteus_oculatus
ENSG00000100823APEX110094.025ENSLAFG00000021872APEX110094.025Loxodonta_africana
ENSG00000100823APEX110097.799ENSMFAG00000002565APEX110097.799Macaca_fascicularis
ENSG00000100823APEX110098.113ENSMMUG00000048039APEX110098.113Macaca_mulatta
ENSG00000100823APEX110098.113ENSMNEG00000036944APEX110098.113Macaca_nemestrina
ENSG00000100823APEX110098.428ENSMLEG00000042125APEX110098.428Mandrillus_leucophaeus
ENSG00000100823APEX18871.326ENSMAMG00000023526apex19966.456Mastacembelus_armatus
ENSG00000100823APEX19959.064ENSMZEG00005014187apex19966.038Maylandia_zebra
ENSG00000100823APEX110093.082ENSMAUG00000013994Apex110093.082Mesocricetus_auratus
ENSG00000100823APEX110095.283ENSMICG00000043554APEX110095.283Microcebus_murinus
ENSG00000100823APEX110092.138ENSMOCG00000013721Apex110092.138Microtus_ochrogaster
ENSG00000100823APEX19956.725ENSMMOG00000010031apex18767.500Mola_mola
ENSG00000100823APEX110083.438ENSMODG00000007125APEX110083.438Monodelphis_domestica
ENSG00000100823APEX18767.333ENSMALG00000011699apex17564.158Monopterus_albus
ENSG00000100823APEX19997.315MGP_CAROLIEiJ_G0019209Apex19993.691Mus_caroli
ENSG00000100823APEX19997.987ENSMUSG00000035960Apex110094.340Mus_musculus
ENSG00000100823APEX19997.987MGP_PahariEiJ_G0030232Apex110094.340Mus_pahari
ENSG00000100823APEX19997.987MGP_SPRETEiJ_G0020101Apex110094.340Mus_spretus
ENSG00000100823APEX110094.062ENSMLUG00000028957APEX110094.062Myotis_lucifugus
ENSG00000100823APEX110082.243ENSNGAG00000021748-9969.811Nannospalax_galili
ENSG00000100823APEX110093.082ENSNGAG00000002725-10093.082Nannospalax_galili
ENSG00000100823APEX18671.636ENSNBRG00000005334apex19165.723Neolamprologus_brichardi
ENSG00000100823APEX110098.428ENSNLEG00000010839APEX110098.428Nomascus_leucogenys
ENSG00000100823APEX110087.107ENSMEUG00000014519APEX110087.107Notamacropus_eugenii
ENSG00000100823APEX110093.396ENSOPRG00000014029APEX110093.082Ochotona_princeps
ENSG00000100823APEX19977.647ENSODEG00000004777-9975.081Octodon_degus
ENSG00000100823APEX110094.654ENSODEG00000001703-10094.654Octodon_degus
ENSG00000100823APEX110071.914ENSODEG00000006583-10071.914Octodon_degus
ENSG00000100823APEX18771.942ENSONIG00000012089apex19966.352Oreochromis_niloticus
ENSG00000100823APEX19082.105ENSOANG00000008836APEX18076.852Ornithorhynchus_anatinus
ENSG00000100823APEX110094.654ENSOCUG00000005022APEX110094.654Oryctolagus_cuniculus
ENSG00000100823APEX19966.667ENSORLG00000012378apex19966.667Oryzias_latipes
ENSG00000100823APEX19966.667ENSORLG00020021371apex19966.667Oryzias_latipes_hni
ENSG00000100823APEX19966.667ENSORLG00015020089apex19966.667Oryzias_latipes_hsok
ENSG00000100823APEX19966.667ENSOMEG00000018876apex19966.667Oryzias_melastigma
ENSG00000100823APEX110094.340ENSOGAG00000013335-10094.340Otolemur_garnettii
ENSG00000100823APEX19989.404ENSOGAG00000029355-10083.974Otolemur_garnettii
ENSG00000100823APEX110092.138ENSOARG00000019740-10092.138Ovis_aries
ENSG00000100823APEX110088.213ENSOARG00000001876-10089.286Ovis_aries
ENSG00000100823APEX19985.000ENSOARG00000014424-10078.165Ovis_aries
ENSG00000100823APEX1100100.000ENSPPAG00000038760APEX110099.686Pan_paniscus
ENSG00000100823APEX110096.541ENSPPRG00000011794APEX110096.541Panthera_pardus
ENSG00000100823APEX110096.226ENSPTIG00000014829APEX110096.226Panthera_tigris_altaica
ENSG00000100823APEX1100100.000ENSPTRG00000006093APEX110099.686Pan_troglodytes
ENSG00000100823APEX110098.428ENSPANG00000022757APEX110098.428Papio_anubis
ENSG00000100823APEX19957.310ENSPKIG00000003504apex110064.486Paramormyrops_kingsleyae
ENSG00000100823APEX17666.667ENSPMGG00000016596apex17366.667Periophthalmus_magnuspinnatus
ENSG00000100823APEX19995.294ENSPEMG00000019097Apex110093.711Peromyscus_maniculatus_bairdii
ENSG00000100823APEX19466.667ENSPMAG00000007275-9569.039Petromyzon_marinus
ENSG00000100823APEX110083.699ENSPCIG00000023274APEX110083.801Phascolarctos_cinereus
ENSG00000100823APEX18872.043ENSPFOG00000004178apex19967.089Poecilia_formosa
ENSG00000100823APEX18871.685ENSPLAG00000012779apex19966.772Poecilia_latipinna
ENSG00000100823APEX18872.043ENSPMEG00000019623apex19967.089Poecilia_mexicana
ENSG00000100823APEX18871.326ENSPREG00000014298apex19966.456Poecilia_reticulata
ENSG00000100823APEX110098.630ENSPPYG00000005565APEX110098.428Pongo_abelii
ENSG00000100823APEX110092.138ENSPCAG00000010376APEX110092.138Procavia_capensis
ENSG00000100823APEX110095.283ENSPCOG00000021564APEX110095.283Propithecus_coquereli
ENSG00000100823APEX110095.312ENSPVAG00000010736APEX110095.312Pteropus_vampyrus
ENSG00000100823APEX19959.064ENSPNYG00000023940apex19966.038Pundamilia_nyererei
ENSG00000100823APEX19864.479ENSPNAG00000020897apex19665.424Pygocentrus_nattereri
ENSG00000100823APEX110093.396ENSRNOG00000009663Apex110093.396Rattus_norvegicus
ENSG00000100823APEX110098.428ENSRBIG00000038325APEX19998.428Rhinopithecus_bieti
ENSG00000100823APEX110098.113ENSSBOG00000018921-10098.113Saimiri_boliviensis_boliviensis
ENSG00000100823APEX19786.624ENSSBOG00000031372-10082.222Saimiri_boliviensis_boliviensis
ENSG00000100823APEX110083.333ENSSHAG00000013524APEX110083.333Sarcophilus_harrisii
ENSG00000100823APEX18766.426ENSSFOG00015001948apex110061.950Scleropages_formosus
ENSG00000100823APEX18769.424ENSSMAG00000013348apex19965.300Scophthalmus_maximus
ENSG00000100823APEX18869.534ENSSDUG00000016377apex19965.190Seriola_dumerili
ENSG00000100823APEX18870.251ENSSLDG00000023005apex19965.823Seriola_lalandi_dorsalis
ENSG00000100823APEX19964.327ENSSPUG00000000531APEX19672.887Sphenodon_punctatus
ENSG00000100823APEX18869.892ENSSPAG00000000458apex19964.873Stegastes_partitus
ENSG00000100823APEX19762.275ENSSSCG00000039705-9259.155Sus_scrofa
ENSG00000100823APEX110094.340ENSSSCG00000040060-10094.340Sus_scrofa
ENSG00000100823APEX17460.169ENSTGUG00000014378APEX110060.169Taeniopygia_guttata
ENSG00000100823APEX19956.471ENSTRUG00000004268apex18468.100Takifugu_rubripes
ENSG00000100823APEX19964.873ENSTNIG00000005778apex19963.608Tetraodon_nigroviridis
ENSG00000100823APEX110091.824ENSTBEG00000006405APEX110091.824Tupaia_belangeri
ENSG00000100823APEX17495.339ENSTTRG00000007860APEX110095.339Tursiops_truncatus
ENSG00000100823APEX110095.283ENSUAMG00000010457APEX110095.283Ursus_americanus
ENSG00000100823APEX110095.283ENSUMAG00000009178APEX110095.283Ursus_maritimus
ENSG00000100823APEX17490.254ENSVPAG00000005083APEX110090.254Vicugna_pacos
ENSG00000100823APEX110094.654ENSVVUG00000009010APEX110094.654Vulpes_vulpes
ENSG00000100823APEX110066.563ENSXETG00000024773apex110066.563Xenopus_tropicalis
ENSG00000100823APEX18871.685ENSXCOG00000015233apex19966.772Xiphophorus_couchianus
ENSG00000100823APEX19569.103ENSXMAG00000006195apex19966.772Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000723telomere maintenance24703901.IDAProcess
GO:0000784nuclear chromosome, telomeric region24703901.ICComponent
GO:0003677DNA binding11286553.IDAFunction
GO:0003684damaged DNA binding12524539.14706345.24703901.IDAFunction
GO:0003691double-stranded telomeric DNA binding24703901.IDAFunction
GO:0003713transcription coactivator activity9119221.IDAFunction
GO:0003714transcription corepressor activity7961715.TASFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity21873635.IBAFunction
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity8932386.15707971.18973764.19188445.24703901.IDAFunction
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity9119221.TASFunction
GO:0004519endonuclease activity11478795.IDAFunction
GO:0004520endodeoxyribonuclease activity-TASFunction
GO:0004523RNA-DNA hybrid ribonuclease activity11286553.TASFunction
GO:0004528phosphodiesterase I activity21873635.IBAFunction
GO:0004528phosphodiesterase I activity9119221.TASFunction
GO:0004844uracil DNA N-glycosylase activity10805771.TASFunction
GO:0005515protein binding8621488.9207062.11118054.11809897.12524539.15518571.15942031.18809583.19188445.19465398.19505873.19934257.20231292.20696907.20808282.20856196.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus9119221.15942031.19934257.IDAComponent
GO:0005654nucleoplasm17148573.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005667transcription factor complex-IEAComponent
GO:0005730nucleolus17148573.19188445.IDAComponent
GO:0005737cytoplasm9560228.IDAComponent
GO:0005739mitochondrion20231292.IDAComponent
GO:0005783endoplasmic reticulum12524539.TASComponent
GO:0005813centrosome-IDAComponent
GO:0005840ribosome12524539.TASComponent
GO:0006281DNA repair9560228.IDAProcess
GO:0006284base-excision repair21873635.IBAProcess
GO:0006284base-excision repair8932386.IDAProcess
GO:0006284base-excision repair-TASProcess
GO:0006286base-excision repair, base-free sugar-phosphate removal-TASProcess
GO:0006310DNA recombination-IEAProcess
GO:0007568aging-IEAProcess
GO:0008081phosphoric diester hydrolase activity11478795.18973764.IDAFunction
GO:0008309double-stranded DNA exodeoxyribonuclease activity24703901.IDAFunction
GO:0008311double-stranded DNA 3'-5' exodeoxyribonuclease activity21873635.IBAFunction
GO:00084083'-5' exonuclease activity11832948.IDAFunction
GO:00084083'-5' exonuclease activity11286553.TASFunction
GO:0014912negative regulation of smooth muscle cell migration-IEAProcess
GO:0016491oxidoreductase activity9119221.12524539.IDAFunction
GO:0016607nuclear speck17148573.IDAComponent
GO:0016890site-specific endodeoxyribonuclease activity, specific for altered base19188445.24703901.IDAFunction
GO:0031490chromatin DNA binding11809897.IDAFunction
GO:0042981regulation of apoptotic process19934257.IDAProcess
GO:0043488regulation of mRNA stability19401441.IMPProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0045454cell redox homeostasis-IEAProcess
GO:0046872metal ion binding11286553.IDAFunction
GO:0048471perinuclear region of cytoplasm12524539.IDAComponent
GO:0051059NF-kappaB binding-IEAFunction
GO:0055114oxidation-reduction process-IEAProcess
GO:0070301cellular response to hydrogen peroxide-IEAProcess
GO:0071320cellular response to cAMP-IEAProcess
GO:0071375cellular response to peptide hormone stimulus-IEAProcess
GO:0080111DNA demethylation21496894.IDAProcess
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
GO:0097698telomere maintenance via base-excision repair24703901.IDAProcess
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IEAFunction
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEAProcess
GO:1903507negative regulation of nucleic acid-templated transcription-IEAProcess
GO:1903508positive regulation of nucleic acid-templated transcription-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us