EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25672588	APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.	Cancer Res Treat	2015 Oct	Shin JH	doi: 10.4143/crt.2014.074
27057081	Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker.	Dis Markers	2016	Choi S	doi: 10.1155/2016/7276502
18061304	Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.	Lung Cancer	2008 May	Yoo DG	-
17974506	Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.	DNA Repair (Amst)	2008 Feb 1	Fishel ML	-
28181292	Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.	Environ Mol Mutagen	2017 Mar	Illuzzi JL	doi: 10.1002/em.22074
18809583	Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.	Mol Cell Biol	2008 Dec	Chattopadhyay R	doi: 10.1128/MCB.00244-08
26981776	Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.	Oncotarget	2016 Apr 19	Bhakat KK	doi: 10.18632/oncotarget.8026.
24329908	Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.	Cancer Sci	2014 Feb	Ren T	doi: 10.1111/cas.12334
16481390	Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).	Mol Pharmacol	2006 May	Lam W	-
20498636	Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation.	Oncogene	2010 Jul 29	Wu HH	doi: 10.1038/onc.2010.178
18627350	Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.	Antioxid Redox Signal	2008 Nov	Luo M	doi: 10.1089/ars.2008.2120.
14599768	APE/Ref-1 and the mammalian response to genotoxic stress.	Toxicology	2003 Nov 15	Fritz G	-
28986522	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	Nat Commun	2017 Oct 6	Antoniali G	doi: 10.1038/s41467-017-00842-8.
27655688	Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.	Oncotarget	2016 Nov 15	Sengupta S	doi: 10.18632/oncotarget.12113.
25945024	Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis.	World J Gastroenterol	2015 Apr 28	Dai ZJ	doi: 10.3748/wjg.v21.i16.5081.
20354815	Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China.	Med Oncol	2011 Sep	Deng Q	doi: 10.1007/s12032-010-9507-2
23749940	The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk.	Anticancer Res	2013 Jun	Chen WC	-
26314200	The association of ApE1 -656T>G and 1349T>G polymorphisms with breast cancer susceptibility in northern Iran.	Cell Mol Biol (Noisy-le-grand)	2015 Aug 28	Mashayekhi F	-
23065211	Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.	Mol Biol Rep	2012 Dec	Wei W	doi: 10.1007/s11033-012-2035-8
26045303	Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk.	Carcinogenesis	2015 Sep	Sevilya Z	doi: 10.1093/carcin/bgv082
22176746	The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies.	BMC Cancer	2011 Dec 18	Zhou B	doi: 10.1186/1471-2407-11-521.
27553367	Silencing of Apurinic/Apyrimidinic Endonuclease 1 Inhibits the Growth and Migration in Ovarian Cancer Cell via Activator-Protein-1 Signaling.	Gynecol Obstet Invest	2017	Kong Q	doi: 10.1159/000447261
23831574	Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.	Oncogene	2014 May 29	Vascotto C	doi: 10.1038/onc.2013.251
19041121	Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India.	Urology	2009 Mar	Gangwar R	doi: 10.1016/j.urology.2008.09.043
26255264	The association between 1349T>G polymorphism of ApE1 gene and the risk of prostate cancer in northern Iran.	Cell Mol Biol (Noisy-le-grand)	2015 Aug 5	Pournourali M	-
24257553	Apurinic/apyrimidinic endonuclease 1 polymorphisms are associated with ovarian cancer susceptibility in a Chinese population.	Int J Gynecol Cancer	2013 Oct	Zhang X	doi: 10.1097/IGC.0b013e3182a33f07.
25033834	APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions.	Exp Mol Med	2014 Jul 18	Thakur S	doi: 10.1038/emm.2014.42.
23038158	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	J Epidemiol	2012	Lin CH	doi: 10.2188/jea.JE20120048
24914806	Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.	PLoS One	2014 Jun 10	Woo J	doi: 10.1371/journal.pone.0099528
20218899	Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.	DNA Cell Biol	2010 Jun	Wang M	doi: 10.1089/dna.2009.0969.
15316562	Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.	Br J Cancer	2004 Sep 13	Lau JP	-
23430444	Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population.	Med Oncol	2013 Jun	Li Y	doi: 10.1007/s12032-013-0505-z
19292061	[The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer].	Sichuan Da Xue Xue Bao Yi Xue Ban	2009 Jan	Qing Y	-
26125438	Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation.	Oncotarget	2015 Sep 15	Lee YR	-
17332344	Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.	Cancer Res	2007 Mar 1	Raffoul JJ	-
25107571	Predictive value of APE1, BRCA1, ERCC1 and TUBB3 expression in patients with advanced non-small cell lung cancer (NSCLC) receiving first-line platinum-paclitaxel chemotherapy.	Cancer Chemother Pharmacol	2014 Oct	Li Z	doi: 10.1007/s00280-014-2562-1
26359670	Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry.	Biochemistry	2015 Sep 29	Coskun E	doi: 10.1021/acs.biochem.5b00928
23408843	Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.	Mutagenesis	2013 Mar	Mahjabeen I	doi: 10.1093/mutage/ges074.
23094050	APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.	PLoS One	2012	Cardoso AA	doi: 10.1371/journal.pone.0047462
26081414	Ape1 regulates WNT/β-catenin signaling through its redox functional domain in pancreatic cancer cells.	Int J Oncol	2015 Aug	Jiang S	doi: 10.3892/ijo.2015.3048
23272074	Lack of an association between two BER gene polymorphisms and breast cancer risk: a meta-analysis.	PLoS One	2012	Wu B	doi: 10.1371/journal.pone.0050857
26257461	Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk.	Dis Markers	2015	AlMutairi F	doi: 10.1155/2015/869512
21132382	APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis.	Mol Biol Rep	2011 Oct	Ji YN	doi: 10.1007/s11033-010-0584-2
17949784	Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.	Hum Pathol	2008 Feb	Noike T	-
24254302	The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis.	Tumour Biol	2014 Mar	Shen E	doi: 10.1007/s13277-013-1334-6
21037106	Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.	Cancer Epidemiol Biomarkers Prev	2010 Dec	Brevik A	doi: 10.1158/1055-9965.EPI-10-0606
24606430	Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese population.	Asian Pac J Cancer Prev	2014	Luo H	-
19787261	Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor.	Int J Oncol	2009 Nov	Zhang Y	-
25023401	Association between APE1 T1349G polymorphism and prostate cancer risk: evidence from a meta-analysis.	Tumour Biol	2014 Oct	Li X	doi: 10.1007/s13277-014-2115-6
25733810	Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer.	Drug Des Devel Ther	2015 Feb 16	Qing Y	doi: 10.2147/DDDT.S75152
24414702	The association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility: a meta-analysis based on case-control studies.	Tumour Biol	2014 May	Zhao Z	doi: 10.1007/s13277-014-1618-5
25344644	Susceptibility and REF1 gene polymorphism towards colorectal cancer.	Cell Biochem Biophys	2015 Mar	Yang S	doi: 10.1007/s12013-014-0296-7.
21615620	A genetic variation in APE1 is associated with gastric cancer survival in a Chinese population.	Cancer Sci	2011 Jul	Zhao Q	doi: 10.1111/j.1349-7006.2011.01959.x
23994194	A genetic variant in the promoter of APE1 gene (-656 T>G) is associated with breast cancer risk and progression in a Chinese population.	Gene	2013 Nov 15	Kang H	doi: 10.1016/j.gene.2013.08.052
23874853	Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.	PLoS One	2013 Jul 11	Pan H	doi: 10.1371/journal.pone.0069018
20852942	Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.	Mol Biol Rep	2011 Mar	Kuasne H	doi: 10.1007/s11033-010-0267-z
22493391	Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma.	Anticancer Res	2012 Apr	Shukla VK	-
25024628	APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.	World J Gastroenterol	2014 Jul 14	Zhang SH	doi: 10.3748/wjg.v20.i26.8700.
19528510	Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking.	Anticancer Res	2009 Jun	Agahan B	-
23268706	Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro.	Cancer Biother Radiopharm	2013 Mar	Chen S	doi: 10.1089/cbr.2012.1266
24884729	A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy.	Br J Radiol	2014 Aug	Li H	doi: 10.1259/bjr.20140093
18503157	Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.	Cancer Biomark	2008	Shekari M	-
24893568	Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis.	Diagn Pathol	2014 Jun 3	Peng Q	doi: 10.1186/1746-1596-9-108.
19541747	Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.	FASEB J	2009 Oct	Lu J	doi: 10.1096/fj.09-136549
21722819	Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population.	Arch Med Res	2011 Apr	Li Z	doi: 10.1016/j.arcmed.2011.04.005.
21198260	APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.	Asian Pac J Cancer Prev	2010	Osawa K	-
27802207	APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target.	Cancer Biomark	2016 Sep 26	Wen X	-
24523018	APE1 Asp148Glu polymorphism and lung cancer susceptibility.	Tumour Biol	2014 Jun	Cai L	doi: 10.1007/s13277-014-1681-y
20919954	Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.	Cancer Invest	2010 Nov	Jiang Y	doi: 10.3109/07357907.2010.512816.
19762350	The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies.	Mutagenesis	2009 Nov	Gu D	doi: 10.1093/mutage/gep036
26373042	Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).	J Nanosci Nanotechnol	2015 Jul	Elingarami S	-
18823566	Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.	J Exp Clin Cancer Res	2008 Sep 30	Kasahara M	doi: 10.1186/1756-9966-27-49.
19124501	A polymorphism in the APE1 gene promoter is associated with lung cancer risk.	Cancer Epidemiol Biomarkers Prev	2009 Jan	Lo YL	doi: 10.1158/1055-9965.EPI-08-0749.
24705777	Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer.	Tumour Biol	2014 Jul	Jin F	doi: 10.1007/s13277-014-1829-9
17034901	Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.	Lung Cancer	2006 Dec	Ryk C	-
19242824	Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India.	Med Oncol	2010 Jun	Gangawar R	doi: 10.1007/s12032-009-9187-y
24349526	APEX nuclease (multifunctional DNA repair enzyme) 1 gene Asp148Glu polymorphism and cancer risk: a meta-analysis involving 58 articles and 48903 participants.	PLoS One	2013 Dec 12	Hu D	doi: 10.1371/journal.pone.0083527
19097035	The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis.	J Cell Physiol	2009 Apr	Zou GM	doi: 10.1002/jcp.21666.
25234162	The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case-control studies.	Mol Genet Genomics	2015 Feb	Zhou X	doi: 10.1007/s00438-014-0916-3
22205985	The DNA repair gene APE1 T1349G polymorphism and risk of gastric cancer in a Chinese population.	PLoS One	2011	Gu D	doi: 10.1371/journal.pone.0028971
17855454	Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.	Hum Mol Genet	2007 Oct 1	Matakidou A	-
23110144	Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.	PLoS One	2012	Dorjsuren D	doi: 10.1371/journal.pone.0047974
19188437	Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.	Mol Cell Biol	2009 Apr	Kim MH	doi: 10.1128/MCB.01484-08
17922186	Polymorphisms in three base excision repair genes and breast cancer risk in Thai women.	Breast Cancer Res Treat	2008 Sep	Sangrajrang S	-
26292623	Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.	Med Sci Monit	2015 Aug 21	Li H	doi: 10.12659/MSM.893954.
24076439	Impact of genetic polymorphisms in base excision repair genes on the risk of breast cancer in a Korean population.	Gene	2013 Dec 15	Kim KY	doi: 10.1016/j.gene.2013.09.069
23776569	Functional assessment of population and tumor-associated APE1 protein variants.	PLoS One	2013 Jun 11	Illuzzi JL	doi: 10.1371/journal.pone.0065922
18669164	Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women.	Oncol Res	2008	Mitra AK	-
23479135	Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer.	Cancer Chemother Pharmacol	2013 May	Zhao W	doi: 10.1007/s00280-013-2127-8
20530453	Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer.	Anticancer Res	2010 Apr	Canbay E	-
21479902	Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer.	Med Oncol	2012 Jun	Sheng Q	doi: 10.1007/s12032-011-9931-y
15816625	Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.	Anticancer Res	2005 Jan-Feb	Shen M	-
23143180	APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis.	Mol Biol Rep	2013 Jan	Liu C	doi: 10.1007/s11033-012-2046-5
25156607	The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese.	Mol Carcinog	2015 Jun	Li X	doi: 10.1002/mc.22195
23871947	Genetic variant in APE1 gene promoter contributes to cervical cancer risk.	Am J Obstet Gynecol	2013 Oct	Wang M	doi: 10.1016/j.ajog.2013.07.010
21561390	Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.	Curr Med Res Opin	2011 Jul	Canbay E	doi: 10.1185/03007995.2011.573544
24310503	The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis.	Tumour Biol	2014 Apr	Chen W	doi: 10.1007/s13277-013-1474-8
26146106	Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population.	Pol Przegl Chir	2015 Mar	Kabzi??ski J	doi: 10.1515/pjs-2015-0030.
19324449	APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells.	Lung Cancer	2009 Dec	Wang D	doi: 10.1016/j.lungcan.2009.02.019
25292033	Germline variations of apurinic/apyrimidinic endonuclease 1 (APEX1) detected in female breast cancer patients.	Asian Pac J Cancer Prev	2014	Ali K	-
16221808	Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.	Am J Epidemiol	2005 Nov 15	Hung RJ	-
24284961	Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.	Am J Physiol Gastrointest Liver Physiol	2014 Feb	Nagoya H	doi: 10.1152/ajpgi.00057.2013
18357393	Prevalence of BER gene polymorphisms in sporadic breast cancer.	Oncol Rep	2008 Apr	Ali MF	-
27539671	Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls.	Breast Cancer	2017 May	Hsieh WC	doi: 10.1007/s12282-016-0719-y
29064327	The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib.	Tumour Biol	2017 Oct	Chen T	doi: 10.1177/1010428317713390.
27248666	Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.	Oncotarget	2016 Aug 9	Chen Y	doi: 10.18632/oncotarget.9693.
27050370	APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.	Oncotarget	2016 May 3	Lirussi L	doi: 10.18632/oncotarget.8477.
27388124	Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.	Sci Rep	2016 Jul 8	Nassour H	doi: 10.1038/srep29389.
28887667	APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells.	Mol Cell Biochem	2018 Apr	Thakur S	doi: 10.1007/s11010-017-3186-7
30703296	Workers.	Radiats Biol Radioecol	2016 Jul	Rusinova GG	-
29720094	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China.	BMC Med Genet	2018 May 2	Wang T	doi: 10.1186/s12881-018-0578-9.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr14	20457398	Missense_Mutation	NA	D283H	0.46
BLCA	chr14	20457042	Missense_Mutation	rs778999137	S164L	0.41
BRCA	chr14	20457511	3'UTR	rs774168347		0.34
BRCA	chr14	20455930	Silent	NA	K25K	0.15
BRCA	chr14	20457104	Missense_Mutation	rs765234188	R185W	0.24
BRCA	chr14	20455659	Missense_Mutation	NA	G5A	0.29
BRCA	chr14	20457416	Missense_Mutation	NA	H289Y	0.38
CESC	chr14	20455665	Missense_Mutation	NA	K7R	0.05
CESC	chr14	20457319	Silent	NA	L256L	0.29
CESC	chr14	20455597	5'UTR	novel		0.15
CESC	chr14	20457392	Missense_Mutation	rs751223947	R281C	0.37
COAD	chr14	20457213	Missense_Mutation	rs778698391	R221H	0.24
COAD	chr14	20457364	Missense_Mutation	novel	M271I	0.11
COAD	chr14	20457584	3'UTR	novel		0.32
COAD	chr14	20457240	Missense_Mutation	NA	A230D	0.29
COAD	chr14	20456810	Missense_Mutation	NA	G130D	0.11	Exo_endo_phos
COAD	chr14	20457239	Missense_Mutation	NA	A230T	0.22
ESCA	chr14	20455530	Intron	novel		0.27
ESCA	chr14	20457044	Missense_Mutation	novel	F165V	0.42
GBM	chr14	20457411	Frame_Shift_Ins	novel	*L287Ffs11**	0.06
GBM	chr14	20456820	Frame_Shift_Ins	novel	*L134Sfs16**	0.24	Exo_endo_phos
LGG	chr14	20457285	Missense_Mutation	novel	Q245R	0.34
LGG	chr14	20457418	Missense_Mutation	novel	H289Q	0.72
LIHC	chr14	20457210	Missense_Mutation	novel	L220P	0.26
LIHC	chr14	20457389	Missense_Mutation	novel	W280R	0.34
LUAD	chr14	20456765	Missense_Mutation	novel	S115F	0.18	Exo_endo_phos
LUAD	chr14	20457164	Frame_Shift_Ins	novel	*V206Cfs11**	0.16
LUAD	chr14	20455611	5'UTR	novel		0.18
LUSC	chr14	20455526	Intron	novel		0.63
LUSC	chr14	20455936	Silent	novel	K27K	0.26
LUSC	chr14	20455937	Missense_Mutation	novel	T28S	0.27
OV	chr14	20457233	Nonsense_Mutation	novel	K228*	0.05
OV	chr14	20457238	Silent	novel	N229N	0.1
OV	chr14	20457572	3'UTR	novel		0.11
OV	chr14	20457129	Missense_Mutation	rs367614890	R193H	0.38
READ	chr14	20457128	Missense_Mutation	rs778301776	R193C	0.51
READ	chr14	20457372	Missense_Mutation	rs374977590	R274Q	0.42
SARC	chr14	20455958	Frame_Shift_Del	rs764279183	*K35Rfs11**	0.48
SKCM	chr14	20455691	Missense_Mutation	NA	E16K	0.23
SKCM	chr14	20455538	Intron	novel		0.57
SKCM	chr14	20457637	3'UTR	novel		0.26
STAD	chr14	20456855	Missense_Mutation	novel	G145D	0.63
STAD	chr14	20456726	Missense_Mutation	NA	N102I	0.08	Exo_endo_phos
STAD	chr14	20455653	Missense_Mutation	NA	K3R	0.1
STAD	chr14	20455654	Silent	NA	K3K	0.26
UCEC	chr14	20456671	Missense_Mutation	novel	V84I	0.13	Exo_endo_phos
UCEC	chr14	20456790	Silent	novel	S123S	0.15
UCEC	chr14	20457665	3'UTR	novel		0.45
UCEC	chr14	20455921	Silent	NA	E22E	0.19
UCEC	chr14	20456811	Silent	rs776338830	G130G	0.25
UCEC	chr14	20457070	Silent	NA	P173P	0.15
UCEC	chr14	20457060	Missense_Mutation	novel	A170V	0.22
UCEC	chr14	20457591	3'UTR	novel		0.3
UCEC	chr14	20457219	Missense_Mutation	novel	P223L	0.59
UCEC	chr14	20457694	3'UTR	rs3189662		0.42
UCEC	chr14	20457042	Missense_Mutation	rs778999137	S164L	0.42
UCEC	chr14	20457129	Missense_Mutation	rs367614890	R193H	0.13
UCEC	chr14	20457384	Missense_Mutation	novel	V278D	0.41
UCEC	chr14	20457213	Missense_Mutation	rs778698391	R221H	0.27
UCS	chr14	20457493	Silent	novel	L314L	0.07
UCS	chr14	20457129	Missense_Mutation	rs367614890	R193H	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
DLBC	DEL	0.0417	0.18166
HNSC	DEL	0.1054	0.0025503
KIRP	DEL	0.1632	0.085174
LUSC	DEL	0.2555	0.0082553
PAAD	DEL	0.087	0.11332
READ	DEL	0.3697	0.0043084
THCA	DEL	0.002	0.221
UCEC	DEL	0.0946	5.8317e-06
UCS	DEL	0.4286	0.19877
UVM	DEL	0.0125	0.22482

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0017	Kaplan-Meier Survival Analysis
SARC	0.0082	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
ACC	0.0028	Kaplan-Meier Survival Analysis
HNSC	0.04	Kaplan-Meier Survival Analysis
LUSC	0.022	Kaplan-Meier Survival Analysis
TGCT	0.05	Kaplan-Meier Survival Analysis
COAD	0.05	Kaplan-Meier Survival Analysis
GBM	0.028	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.0007	Kaplan-Meier Survival Analysis
OV	0.0032	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000100823 (Gene tree)
Gene ID: 328
Gene Symbol: APEX1
Alias: APE|REF1|HAP1|APX|APEN|REF-1|APE-1|APEX
Full Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 2,642 bases
Position: chr14:20,455,131-20,457,772
Accession: 587
Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000216714	Exo_endo_phos	PF03372.23	3.4e-21	1	1
ENSP00000381111	Exo_endo_phos	PF03372.23	3.4e-21	1	1
ENSP00000451979	Exo_endo_phos	PF03372.23	3.4e-21	1	1
ENSP00000451327	Exo_endo_phos	PF03372.23	7.6e-16	1	1
ENSP00000452460	Exo_endo_phos	PF03372.23	1.2e-14	1	1
ENSP00000416414	Exo_endo_phos	PF03372.23	1e-13	1	1
ENSP00000451060	Exo_endo_phos	PF03372.23	1.3e-07	1	1
ENSP00000452418	Exo_endo_phos	PF03372.23	1.6e-07	1	1
ENSP00000451170	Exo_endo_phos	PF03372.23	2e-07	1	1
ENSP00000452137	Exo_endo_phos	PF03372.23	7.5e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21762700	Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.	J Mol Biol	2011 Sep 2	Kim WC	doi: 10.1016/j.jmb.2011.06.050
19188445	APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.	Mol Cell Biol	2009 Apr	Vascotto C	doi: 10.1128/MCB.01337-08
20032196	Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.	Mol Endocrinol	2010 Feb	Ray S	doi: 10.1210/me.2009-0319
17114472	Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.	J Immunol	2006 Dec 1	O'Hara AM	-
20699270	Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.	Nucleic Acids Res	2010 Dec	Fantini D	doi: 10.1093/nar/gkq691
23544830	Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).	Biochem J	2013 Jun 15	Poletto M	doi: 10.1042/BJ20121277.
26432868	and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.	Am J Physiol Lung Cell Mol Physiol	2015 Dec 1	Pastukh V	doi: 10.1152/ajplung.00236.2015

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556296	APEX1-213	571	-	-	- (aa)	-	-
ENST00000554813	APEX1-208	654	-	-	- (aa)	-	-
ENST00000398030	APEX1-202	1387	-	ENSP00000381111	318 (aa)	-	P27695
ENST00000557159	APEX1-216	1803	-	-	- (aa)	-	-
ENST00000553555	APEX1-205	1603	-	-	- (aa)	-	-
ENST00000438886	APEX1-203	451	-	ENSP00000416414	150 (aa)	-	H7C4A8
ENST00000557344	APEX1-218	671	-	ENSP00000452137	146 (aa)	-	A0A0C4DGK8
ENST00000557365	APEX1-219	831	-	-	- (aa)	-	-
ENST00000557150	APEX1-215	740	-	ENSP00000452418	162 (aa)	-	G3V5M0
ENST00000555306	APEX1-209	898	-	-	- (aa)	-	-
ENST00000557181	APEX1-217	566	-	ENSP00000452304	107 (aa)	-	G3V5D9
ENST00000556054	APEX1-212	773	-	ENSP00000451170	174 (aa)	-	G3V3C7
ENST00000553368	APEX1-204	304	-	ENSP00000451491	41 (aa)	-	G3V3Y6
ENST00000216714	APEX1-201	1484	-	ENSP00000216714	318 (aa)	-	P27695
ENST00000554325	APEX1-207	568	-	ENSP00000450604	49 (aa)	-	G3V2D9
ENST00000555839	APEX1-211	952	-	ENSP00000452460	242 (aa)	-	G3V5Q1
ENST00000553681	APEX1-206	899	-	ENSP00000451327	263 (aa)	-	G3V3M6
ENST00000557592	APEX1-220	640	-	ENSP00000451060	172 (aa)	-	G3V359
ENST00000555414	APEX1-210	1437	-	ENSP00000451979	318 (aa)	-	P27695
ENST00000557054	APEX1-214	888	-	ENSP00000452212	14 (aa)	-	G3V574

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100823's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100823	APEX1	88	69.534	ENSAPOG00000017002	apex1	91	69.534	Acanthochromis_polyacanthus
ENSG00000100823	APEX1	100	95.597	ENSAMEG00000005418	APEX1	100	95.597	Ailuropoda_melanoleuca
ENSG00000100823	APEX1	99	59.649	ENSACIG00000010653	apex1	94	71.326	Amphilophus_citrinellus
ENSG00000100823	APEX1	88	69.534	ENSAOCG00000009649	apex1	90	69.534	Amphiprion_ocellaris
ENSG00000100823	APEX1	88	69.534	ENSAPEG00000021453	apex1	90	69.534	Amphiprion_percula
ENSG00000100823	APEX1	99	59.064	ENSATEG00000002883	apex1	97	66.772	Anabas_testudineus
ENSG00000100823	APEX1	100	69.255	ENSACAG00000008099	APEX1	100	69.255	Anolis_carolinensis
ENSG00000100823	APEX1	100	97.799	ENSANAG00000030117	APEX1	100	97.799	Aotus_nancymaae
ENSG00000100823	APEX1	99	59.064	ENSACLG00000018441	apex1	99	66.038	Astatotilapia_calliptera
ENSG00000100823	APEX1	100	65.625	ENSAMXG00000034699	apex1	100	65.625	Astyanax_mexicanus
ENSG00000100823	APEX1	100	93.711	ENSBTAG00000002745	APEX1	100	93.711	Bos_taurus
ENSG00000100823	APEX1	92	40.741	WBGene00001372	exo-3	88	45.312	Caenorhabditis_elegans
ENSG00000100823	APEX1	100	98.428	ENSCJAG00000009726	APEX1	100	98.428	Callithrix_jacchus
ENSG00000100823	APEX1	100	95.283	ENSCAFG00000032033	APEX1	100	95.283	Canis_familiaris
ENSG00000100823	APEX1	100	91.781	ENSCAFG00020023002	-	96	91.860	Canis_lupus_dingo
ENSG00000100823	APEX1	100	95.283	ENSCAFG00020014377	-	100	95.283	Canis_lupus_dingo
ENSG00000100823	APEX1	97	80.469	ENSCHIG00000014537	-	99	74.679	Capra_hircus
ENSG00000100823	APEX1	100	93.082	ENSCHIG00000007298	-	100	93.082	Capra_hircus
ENSG00000100823	APEX1	100	94.654	ENSTSYG00000034813	APEX1	100	94.654	Carlito_syrichta
ENSG00000100823	APEX1	85	88.561	ENSCAPG00000016235	APEX1	91	97.458	Cavia_aperea
ENSG00000100823	APEX1	100	94.340	ENSCPOG00000030909	APEX1	100	94.340	Cavia_porcellus
ENSG00000100823	APEX1	95	94.872	ENSCCAG00000031931	-	100	84.906	Cebus_capucinus
ENSG00000100823	APEX1	100	98.428	ENSCCAG00000033056	-	100	98.428	Cebus_capucinus
ENSG00000100823	APEX1	100	98.428	ENSCATG00000015580	APEX1	100	98.428	Cercocebus_atys
ENSG00000100823	APEX1	100	94.654	ENSCLAG00000001002	APEX1	100	94.654	Chinchilla_lanigera
ENSG00000100823	APEX1	100	98.131	ENSCSAG00000016670	-	100	98.113	Chlorocebus_sabaeus
ENSG00000100823	APEX1	100	98.131	ENSCSAG00000016685	-	100	98.113	Chlorocebus_sabaeus
ENSG00000100823	APEX1	100	72.100	ENSCPBG00000009567	APEX1	100	72.100	Chrysemys_picta_bellii
ENSG00000100823	APEX1	93	53.465	ENSCING00000008137	-	84	58.113	Ciona_intestinalis
ENSG00000100823	APEX1	83	51.698	ENSCSAVG00000007144	-	100	52.510	Ciona_savignyi
ENSG00000100823	APEX1	100	98.428	ENSCANG00000030726	APEX1	100	98.428	Colobus_angolensis_palliatus
ENSG00000100823	APEX1	99	93.529	ENSCGRG00001017046	Apex1	100	92.138	Cricetulus_griseus_chok1gshd
ENSG00000100823	APEX1	99	93.529	ENSCGRG00000008984	Apex1	100	92.138	Cricetulus_griseus_crigri
ENSG00000100823	APEX1	99	65.094	ENSCSEG00000017499	apex1	99	65.094	Cynoglossus_semilaevis
ENSG00000100823	APEX1	88	70.968	ENSCVAG00000022075	apex1	99	65.823	Cyprinodon_variegatus
ENSG00000100823	APEX1	100	66.038	ENSDARG00000045843	apex1	100	66.038	Danio_rerio
ENSG00000100823	APEX1	99	92.353	ENSDNOG00000042234	APEX1	95	89.308	Dasypus_novemcinctus
ENSG00000100823	APEX1	100	94.340	ENSDORG00000001616	Apex1	100	94.340	Dipodomys_ordii
ENSG00000100823	APEX1	100	93.711	ENSETEG00000004855	-	100	93.711	Echinops_telfairi
ENSG00000100823	APEX1	75	64.854	ENSEBUG00000000622	-	92	64.854	Eptatretus_burgeri
ENSG00000100823	APEX1	100	96.226	ENSEASG00005017489	APEX1	74	96.226	Equus_asinus_asinus
ENSG00000100823	APEX1	100	96.226	ENSECAG00000022325	APEX1	82	96.226	Equus_caballus
ENSG00000100823	APEX1	98	92.453	ENSEEUG00000012569	APEX1	100	93.750	Erinaceus_europaeus
ENSG00000100823	APEX1	100	65.517	ENSELUG00000021706	apex1	100	65.938	Esox_lucius
ENSG00000100823	APEX1	100	96.226	ENSFCAG00000030869	APEX1	100	96.226	Felis_catus
ENSG00000100823	APEX1	100	93.396	ENSFDAG00000006120	APEX1	100	93.396	Fukomys_damarensis
ENSG00000100823	APEX1	99	67.405	ENSFHEG00000009031	apex1	83	67.405	Fundulus_heteroclitus
ENSG00000100823	APEX1	99	61.635	ENSGMOG00000007943	apex1	99	61.442	Gadus_morhua
ENSG00000100823	APEX1	99	67.089	ENSGAFG00000005311	apex1	99	67.089	Gambusia_affinis
ENSG00000100823	APEX1	99	64.873	ENSGACG00000019497	apex1	99	69.173	Gasterosteus_aculeatus
ENSG00000100823	APEX1	100	71.787	ENSGAGG00000014999	APEX1	100	71.787	Gopherus_agassizii
ENSG00000100823	APEX1	100	99.065	ENSGGOG00000002128	APEX1	100	99.057	Gorilla_gorilla
ENSG00000100823	APEX1	99	66.139	ENSHBUG00000005894	apex1	99	66.456	Haplochromis_burtoni
ENSG00000100823	APEX1	100	94.340	ENSHGLG00000002848	APEX1	100	94.340	Heterocephalus_glaber_female
ENSG00000100823	APEX1	100	94.340	ENSHGLG00100017878	APEX1	100	94.340	Heterocephalus_glaber_male
ENSG00000100823	APEX1	99	66.144	ENSHCOG00000009961	apex1	99	65.723	Hippocampus_comes
ENSG00000100823	APEX1	100	67.712	ENSIPUG00000005799	apex1	100	67.398	Ictalurus_punctatus
ENSG00000100823	APEX1	100	93.711	ENSSTOG00000010096	APEX1	100	93.711	Ictidomys_tridecemlineatus
ENSG00000100823	APEX1	100	94.025	ENSJJAG00000012067	-	100	94.025	Jaculus_jaculus
ENSG00000100823	APEX1	100	84.591	ENSJJAG00000003660	-	100	84.591	Jaculus_jaculus
ENSG00000100823	APEX1	99	82.803	ENSJJAG00000020465	-	96	84.564	Jaculus_jaculus
ENSG00000100823	APEX1	88	71.326	ENSKMAG00000021171	apex1	99	66.139	Kryptolebias_marmoratus
ENSG00000100823	APEX1	88	68.459	ENSLBEG00000010248	apex1	99	64.217	Labrus_bergylta
ENSG00000100823	APEX1	100	67.601	ENSLACG00000008617	APEX1	100	66.981	Latimeria_chalumnae
ENSG00000100823	APEX1	100	66.770	ENSLOCG00000015516	apex1	99	66.355	Lepisosteus_oculatus
ENSG00000100823	APEX1	100	94.025	ENSLAFG00000021872	APEX1	100	94.025	Loxodonta_africana
ENSG00000100823	APEX1	100	97.799	ENSMFAG00000002565	APEX1	100	97.799	Macaca_fascicularis
ENSG00000100823	APEX1	100	98.113	ENSMMUG00000048039	APEX1	100	98.113	Macaca_mulatta
ENSG00000100823	APEX1	100	98.113	ENSMNEG00000036944	APEX1	100	98.113	Macaca_nemestrina
ENSG00000100823	APEX1	100	98.428	ENSMLEG00000042125	APEX1	100	98.428	Mandrillus_leucophaeus
ENSG00000100823	APEX1	88	71.326	ENSMAMG00000023526	apex1	99	66.456	Mastacembelus_armatus
ENSG00000100823	APEX1	99	59.064	ENSMZEG00005014187	apex1	99	66.038	Maylandia_zebra
ENSG00000100823	APEX1	100	93.082	ENSMAUG00000013994	Apex1	100	93.082	Mesocricetus_auratus
ENSG00000100823	APEX1	100	95.283	ENSMICG00000043554	APEX1	100	95.283	Microcebus_murinus
ENSG00000100823	APEX1	100	92.138	ENSMOCG00000013721	Apex1	100	92.138	Microtus_ochrogaster
ENSG00000100823	APEX1	99	56.725	ENSMMOG00000010031	apex1	87	67.500	Mola_mola
ENSG00000100823	APEX1	100	83.438	ENSMODG00000007125	APEX1	100	83.438	Monodelphis_domestica
ENSG00000100823	APEX1	87	67.333	ENSMALG00000011699	apex1	75	64.158	Monopterus_albus
ENSG00000100823	APEX1	99	97.315	MGP_CAROLIEiJ_G0019209	Apex1	99	93.691	Mus_caroli
ENSG00000100823	APEX1	99	97.987	ENSMUSG00000035960	Apex1	100	94.340	Mus_musculus
ENSG00000100823	APEX1	99	97.987	MGP_PahariEiJ_G0030232	Apex1	100	94.340	Mus_pahari
ENSG00000100823	APEX1	99	97.987	MGP_SPRETEiJ_G0020101	Apex1	100	94.340	Mus_spretus
ENSG00000100823	APEX1	100	94.062	ENSMLUG00000028957	APEX1	100	94.062	Myotis_lucifugus
ENSG00000100823	APEX1	100	82.243	ENSNGAG00000021748	-	99	69.811	Nannospalax_galili
ENSG00000100823	APEX1	100	93.082	ENSNGAG00000002725	-	100	93.082	Nannospalax_galili
ENSG00000100823	APEX1	86	71.636	ENSNBRG00000005334	apex1	91	65.723	Neolamprologus_brichardi
ENSG00000100823	APEX1	100	98.428	ENSNLEG00000010839	APEX1	100	98.428	Nomascus_leucogenys
ENSG00000100823	APEX1	100	87.107	ENSMEUG00000014519	APEX1	100	87.107	Notamacropus_eugenii
ENSG00000100823	APEX1	100	93.396	ENSOPRG00000014029	APEX1	100	93.082	Ochotona_princeps
ENSG00000100823	APEX1	99	77.647	ENSODEG00000004777	-	99	75.081	Octodon_degus
ENSG00000100823	APEX1	100	94.654	ENSODEG00000001703	-	100	94.654	Octodon_degus
ENSG00000100823	APEX1	100	71.914	ENSODEG00000006583	-	100	71.914	Octodon_degus
ENSG00000100823	APEX1	87	71.942	ENSONIG00000012089	apex1	99	66.352	Oreochromis_niloticus
ENSG00000100823	APEX1	90	82.105	ENSOANG00000008836	APEX1	80	76.852	Ornithorhynchus_anatinus
ENSG00000100823	APEX1	100	94.654	ENSOCUG00000005022	APEX1	100	94.654	Oryctolagus_cuniculus
ENSG00000100823	APEX1	99	66.667	ENSORLG00000012378	apex1	99	66.667	Oryzias_latipes
ENSG00000100823	APEX1	99	66.667	ENSORLG00020021371	apex1	99	66.667	Oryzias_latipes_hni
ENSG00000100823	APEX1	99	66.667	ENSORLG00015020089	apex1	99	66.667	Oryzias_latipes_hsok
ENSG00000100823	APEX1	99	66.667	ENSOMEG00000018876	apex1	99	66.667	Oryzias_melastigma
ENSG00000100823	APEX1	100	94.340	ENSOGAG00000013335	-	100	94.340	Otolemur_garnettii
ENSG00000100823	APEX1	99	89.404	ENSOGAG00000029355	-	100	83.974	Otolemur_garnettii
ENSG00000100823	APEX1	100	92.138	ENSOARG00000019740	-	100	92.138	Ovis_aries
ENSG00000100823	APEX1	100	88.213	ENSOARG00000001876	-	100	89.286	Ovis_aries
ENSG00000100823	APEX1	99	85.000	ENSOARG00000014424	-	100	78.165	Ovis_aries
ENSG00000100823	APEX1	100	100.000	ENSPPAG00000038760	APEX1	100	99.686	Pan_paniscus
ENSG00000100823	APEX1	100	96.541	ENSPPRG00000011794	APEX1	100	96.541	Panthera_pardus
ENSG00000100823	APEX1	100	96.226	ENSPTIG00000014829	APEX1	100	96.226	Panthera_tigris_altaica
ENSG00000100823	APEX1	100	100.000	ENSPTRG00000006093	APEX1	100	99.686	Pan_troglodytes
ENSG00000100823	APEX1	100	98.428	ENSPANG00000022757	APEX1	100	98.428	Papio_anubis
ENSG00000100823	APEX1	99	57.310	ENSPKIG00000003504	apex1	100	64.486	Paramormyrops_kingsleyae
ENSG00000100823	APEX1	76	66.667	ENSPMGG00000016596	apex1	73	66.667	Periophthalmus_magnuspinnatus
ENSG00000100823	APEX1	99	95.294	ENSPEMG00000019097	Apex1	100	93.711	Peromyscus_maniculatus_bairdii
ENSG00000100823	APEX1	94	66.667	ENSPMAG00000007275	-	95	69.039	Petromyzon_marinus
ENSG00000100823	APEX1	100	83.699	ENSPCIG00000023274	APEX1	100	83.801	Phascolarctos_cinereus
ENSG00000100823	APEX1	88	72.043	ENSPFOG00000004178	apex1	99	67.089	Poecilia_formosa
ENSG00000100823	APEX1	88	71.685	ENSPLAG00000012779	apex1	99	66.772	Poecilia_latipinna
ENSG00000100823	APEX1	88	72.043	ENSPMEG00000019623	apex1	99	67.089	Poecilia_mexicana
ENSG00000100823	APEX1	88	71.326	ENSPREG00000014298	apex1	99	66.456	Poecilia_reticulata
ENSG00000100823	APEX1	100	98.630	ENSPPYG00000005565	APEX1	100	98.428	Pongo_abelii
ENSG00000100823	APEX1	100	92.138	ENSPCAG00000010376	APEX1	100	92.138	Procavia_capensis
ENSG00000100823	APEX1	100	95.283	ENSPCOG00000021564	APEX1	100	95.283	Propithecus_coquereli
ENSG00000100823	APEX1	100	95.312	ENSPVAG00000010736	APEX1	100	95.312	Pteropus_vampyrus
ENSG00000100823	APEX1	99	59.064	ENSPNYG00000023940	apex1	99	66.038	Pundamilia_nyererei
ENSG00000100823	APEX1	98	64.479	ENSPNAG00000020897	apex1	96	65.424	Pygocentrus_nattereri
ENSG00000100823	APEX1	100	93.396	ENSRNOG00000009663	Apex1	100	93.396	Rattus_norvegicus
ENSG00000100823	APEX1	100	98.428	ENSRBIG00000038325	APEX1	99	98.428	Rhinopithecus_bieti
ENSG00000100823	APEX1	100	98.113	ENSSBOG00000018921	-	100	98.113	Saimiri_boliviensis_boliviensis
ENSG00000100823	APEX1	97	86.624	ENSSBOG00000031372	-	100	82.222	Saimiri_boliviensis_boliviensis
ENSG00000100823	APEX1	100	83.333	ENSSHAG00000013524	APEX1	100	83.333	Sarcophilus_harrisii
ENSG00000100823	APEX1	87	66.426	ENSSFOG00015001948	apex1	100	61.950	Scleropages_formosus
ENSG00000100823	APEX1	87	69.424	ENSSMAG00000013348	apex1	99	65.300	Scophthalmus_maximus
ENSG00000100823	APEX1	88	69.534	ENSSDUG00000016377	apex1	99	65.190	Seriola_dumerili
ENSG00000100823	APEX1	88	70.251	ENSSLDG00000023005	apex1	99	65.823	Seriola_lalandi_dorsalis
ENSG00000100823	APEX1	99	64.327	ENSSPUG00000000531	APEX1	96	72.887	Sphenodon_punctatus
ENSG00000100823	APEX1	88	69.892	ENSSPAG00000000458	apex1	99	64.873	Stegastes_partitus
ENSG00000100823	APEX1	97	62.275	ENSSSCG00000039705	-	92	59.155	Sus_scrofa
ENSG00000100823	APEX1	100	94.340	ENSSSCG00000040060	-	100	94.340	Sus_scrofa
ENSG00000100823	APEX1	74	60.169	ENSTGUG00000014378	APEX1	100	60.169	Taeniopygia_guttata
ENSG00000100823	APEX1	99	56.471	ENSTRUG00000004268	apex1	84	68.100	Takifugu_rubripes
ENSG00000100823	APEX1	99	64.873	ENSTNIG00000005778	apex1	99	63.608	Tetraodon_nigroviridis
ENSG00000100823	APEX1	100	91.824	ENSTBEG00000006405	APEX1	100	91.824	Tupaia_belangeri
ENSG00000100823	APEX1	74	95.339	ENSTTRG00000007860	APEX1	100	95.339	Tursiops_truncatus
ENSG00000100823	APEX1	100	95.283	ENSUAMG00000010457	APEX1	100	95.283	Ursus_americanus
ENSG00000100823	APEX1	100	95.283	ENSUMAG00000009178	APEX1	100	95.283	Ursus_maritimus
ENSG00000100823	APEX1	74	90.254	ENSVPAG00000005083	APEX1	100	90.254	Vicugna_pacos
ENSG00000100823	APEX1	100	94.654	ENSVVUG00000009010	APEX1	100	94.654	Vulpes_vulpes
ENSG00000100823	APEX1	100	66.563	ENSXETG00000024773	apex1	100	66.563	Xenopus_tropicalis
ENSG00000100823	APEX1	88	71.685	ENSXCOG00000015233	apex1	99	66.772	Xiphophorus_couchianus
ENSG00000100823	APEX1	95	69.103	ENSXMAG00000006195	apex1	99	66.772	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	24703901.	IDA	Process
GO:0000784	nuclear chromosome, telomeric region	24703901.	IC	Component
GO:0003677	DNA binding	11286553.	IDA	Function
GO:0003684	damaged DNA binding	12524539.14706345.24703901.	IDA	Function
GO:0003691	double-stranded telomeric DNA binding	24703901.	IDA	Function
GO:0003713	transcription coactivator activity	9119221.	IDA	Function
GO:0003714	transcription corepressor activity	7961715.	TAS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	21873635.	IBA	Function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	8932386.15707971.18973764.19188445.24703901.	IDA	Function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	9119221.	TAS	Function
GO:0004519	endonuclease activity	11478795.	IDA	Function
GO:0004520	endodeoxyribonuclease activity	-	TAS	Function
GO:0004523	RNA-DNA hybrid ribonuclease activity	11286553.	TAS	Function
GO:0004528	phosphodiesterase I activity	21873635.	IBA	Function
GO:0004528	phosphodiesterase I activity	9119221.	TAS	Function
GO:0004844	uracil DNA N-glycosylase activity	10805771.	TAS	Function
GO:0005515	protein binding	8621488.9207062.11118054.11809897.12524539.15518571.15942031.18809583.19188445.19465398.19505873.19934257.20231292.20696907.20808282.20856196.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9119221.15942031.19934257.	IDA	Component
GO:0005654	nucleoplasm	17148573.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005730	nucleolus	17148573.19188445.	IDA	Component
GO:0005737	cytoplasm	9560228.	IDA	Component
GO:0005739	mitochondrion	20231292.	IDA	Component
GO:0005783	endoplasmic reticulum	12524539.	TAS	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005840	ribosome	12524539.	TAS	Component
GO:0006281	DNA repair	9560228.	IDA	Process
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006284	base-excision repair	8932386.	IDA	Process
GO:0006284	base-excision repair	-	TAS	Process
GO:0006286	base-excision repair, base-free sugar-phosphate removal	-	TAS	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0007568	aging	-	IEA	Process
GO:0008081	phosphoric diester hydrolase activity	11478795.18973764.	IDA	Function
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	24703901.	IDA	Function
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	11832948.	IDA	Function
GO:0008408	3'-5' exonuclease activity	11286553.	TAS	Function
GO:0014912	negative regulation of smooth muscle cell migration	-	IEA	Process
GO:0016491	oxidoreductase activity	9119221.12524539.	IDA	Function
GO:0016607	nuclear speck	17148573.	IDA	Component
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	19188445.24703901.	IDA	Function
GO:0031490	chromatin DNA binding	11809897.	IDA	Function
GO:0042981	regulation of apoptotic process	19934257.	IDA	Process
GO:0043488	regulation of mRNA stability	19401441.	IMP	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0046872	metal ion binding	11286553.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	12524539.	IDA	Component
GO:0051059	NF-kappaB binding	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070301	cellular response to hydrogen peroxide	-	IEA	Process
GO:0071320	cellular response to cAMP	-	IEA	Process
GO:0071375	cellular response to peptide hormone stimulus	-	IEA	Process
GO:0080111	DNA demethylation	21496894.	IDA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:0097698	telomere maintenance via base-excision repair	24703901.	IDA	Process
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	-	IEA	Function
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	IEA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

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Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.