EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27315569	Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer.	Int J Oncol	2016 Sep	Kanda M	doi: 10.3892/ijo.2016.3584
29802960	Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer.	Biochim Biophys Acta Mol Basis Dis	2018 Sep	Liu X	doi: 10.1016/j.bbadis.2018.05.015
22266372	Protein arginine methyltransferase 5 is an essential component of the hypoxia-inducible factor 1 signaling pathway.	Biochem Biophys Res Commun	2012 Feb 10	Lim JH	doi: 10.1016/j.bbrc.2012.01.006
28854561	Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.	Carcinogenesis	2017 Aug 1	Saha K	doi: 10.1093/carcin/bgx044.
18694959	Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.	Mol Cell Biol	2008 Oct	Wang L	doi: 10.1128/MCB.00923-08
21700716	Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.	Cancer Res	2011 Aug 15	Powers MA	doi: 10.1158/0008-5472.CAN-11-0458
25220593	Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity.	Neoplasia	2014 Aug	Deng Z	doi: 10.1016/j.neo.2014.07.008.
24453002	Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.	Cancer Res	2014 Mar 15	Yan F	doi: 10.1158/0008-5472.CAN-13-0884
24664369	Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro.	J Neurooncol	2014 May	Han X	doi: 10.1007/s11060-014-1419-0
29185119	PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer.	Breast Cancer Res Treat	2018 Apr	Wang Z	doi: 10.1007/s10549-017-4597-6
22708516	Protein arginine methyltransferase 5 is essential for growth of lung cancer cells.	Biochem J	2012 Sep 1	Gu Z	doi: 10.1042/BJ20120768.
25281873	Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.	Biochim Biophys Acta	2014 Nov	Zhang HT	doi: 10.1016/j.bbagrm.2014.09.015
23292799	Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer.	J Histochem Cytochem	2013 Mar	Bao X	doi: 10.1369/0022155413475452
26912360	MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.	Science	2016 Mar 11	Kryukov GV	doi: 10.1126/science.aad5214
17627275	Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.	EMBO J	2007 Aug 8	Pal S	-
25704480	Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression.	Tumour Biol	2015 Aug	Yang F	doi: 10.1007/s13277-015-3262-0
15701830	Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells.	Clin Cancer Res	2005 Jan 15	Kim JM	-
28381188	Elevated expression of protein arginine methyltransferase 5 predicts the poor prognosis of breast cancer.	Tumour Biol	2017 Apr	Wu Y	doi: 10.1177/1010428317695917.
27546619	Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth.	Oncogene	2017 Mar 2	Deng X	doi: 10.1038/onc.2016.287
27183006	ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.	Elife	2016 May 16	Mounir Z	doi: 10.7554/eLife.13964.
28987382	Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5.	Toxicol Appl Pharmacol	2017 Dec 1	Zhang B	doi: 10.1016/j.taap.2017.10.002
26990556	Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5.	J Gene Med	2016 Apr	Li G	doi: 10.1002/jgm.2878.
28591716	Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.	Oncotarget	2017 Jun 20	Prabhu L	doi: 10.18632/oncotarget.18102.
29262329	PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.	Cell Rep	2017 Dec 19	Chiang K	doi: 10.1016/j.celrep.2017.11.096.
29749478	Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells.	Oncol Rep	2018 Jul	Jeon JY	doi: 10.3892/or.2018.6402

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr14	22922206	Silent	novel	F577F	0.28
BLCA	chr14	22926264	Missense_Mutation	NA	H216Y	0.44
BLCA	chr14	22929289	Missense_Mutation	NA	E25K	0.49
BLCA	chr14	22924653	Missense_Mutation	NA	I332M	0.09
BLCA	chr14	22928583	Missense_Mutation	NA	P48Q	0.23
BRCA	chr14	22924705	Missense_Mutation	NA	L315P	0.34
BRCA	chr14	22922557	Missense_Mutation	NA	P528S	0.14
BRCA	chr14	22929331	Missense_Mutation	NA	G11W	0.43
BRCA	chr14	22920786	3'UTR	novel		0.18
BRCA	chr14	22926264	Missense_Mutation	NA	H216Y	0.2
BRCA	chr14	22928611	Missense_Mutation	NA	D39H	0.28
BRCA	chr14	22924917	In_Frame_Del	novel	E298_F300del	0.31
BRCA	chr14	22929216	Intron	NA		0.18
CESC	chr14	22929323	Silent	rs765654523	R13R	0.11
CESC	chr14	22920733	3'UTR	novel		0.24
CESC	chr14	22925026	Silent	NA	F264F	0.08
CESC	chr14	22926251	Missense_Mutation	rs768729897	R220H	0.37
CESC	chr14	22926805	Missense_Mutation	rs373936905	R154W	0.45
CESC	chr14	22926257	Missense_Mutation	novel	I218S	0.23
CESC	chr14	22923103	Missense_Mutation	NA	S478F	0.49
COAD	chr14	22924921	Silent	NA	L299L	0.38
COAD	chr14	22920881	3'UTR	novel		0.18
COAD	chr14	22922242	Splice_Site	NA	X566_splice	0.18
COAD	chr14	22923140	Missense_Mutation	novel	G466R	0.33
COAD	chr14	22929217	Intron	NA		0.35
COAD	chr14	22924962	Missense_Mutation	NA	Y286H	0.38
COAD	chr14	22929361	Translation_Start_Site	NA	M1?	0.3
COAD	chr14	22922539	Missense_Mutation	NA	R534C	0.22
COAD	chr14	22928150	Missense_Mutation	novel	E97D	0.59
ESCA	chr14	22924938	Missense_Mutation	novel	P294S	0.21
ESCA	chr14	22920799	3'UTR	novel		0.3
GBM	chr14	22924354	Missense_Mutation	novel	V372G	0.08
GBM	chr14	22920976	Silent	novel	E614E	0.55
HNSC	chr14	22924501	Missense_Mutation	novel	E352Q	0.11
HNSC	chr14	22926174	Missense_Mutation	NA	L246F	0.28
HNSC	chr14	22929365	5'UTR	novel		0.32
KIRC	chr14	22924160	Missense_Mutation	NA	E408V	0.26
KIRP	chr14	22924147	In_Frame_Ins	novel	F406_Q412dup	0.1
KIRP	chr14	22924482	Missense_Mutation	novel	V358D	0.21
KIRP	chr14	22928193	Missense_Mutation	NA	V83A	0.41
LGG	chr14	22920957	Missense_Mutation	NA	V621I	0.37
LGG	chr14	22926266	Missense_Mutation	NA	N215S	0.09
LGG	chr14	22924325	Missense_Mutation	novel	A382T	0.25
LGG	chr14	22920991	Silent	novel	K609K	0.35
LIHC	chr14	22929275	Silent	novel	T29T	0.44
LUAD	chr14	22929223	Intron	rs376981525		0.16
LUAD	chr14	22928581	Missense_Mutation	NA	R49C	0.3
LUAD	chr14	22929347	Silent	NA	A5A	0.43
LUAD	chr14	22923093	Nonsense_Mutation	NA	Y481*	0.33
LUAD	chr14	22924337	Missense_Mutation	NA	A378P	0.33
LUAD	chr14	22926556	Splice_Site	novel	X188_splice	0.16
LUAD	chr14	22928536	Missense_Mutation	NA	G64C	0.35
LUAD	chr14	22920976	Missense_Mutation	NA	E614D	0.23
LUSC	chr14	22922485	Missense_Mutation	novel	A552T	0.17
LUSC	chr14	22929241	Intron	novel		0.15
LUSC	chr14	22920990	Nonsense_Mutation	novel	K610*	0.44
LUSC	chr14	22921040	Missense_Mutation	NA	R593L	0.19
LUSC	chr14	22926812	Splice_Region	novel	F151F	0.15
LUSC	chr14	22924643	Nonsense_Mutation	NA	Q336*	0.09
OV	chr14	22924032	Missense_Mutation	rs756575000	D451H	0.04
OV	chr14	22926251	Missense_Mutation	rs768729897	R220H	0.33
OV	chr14	22924925	Missense_Mutation	novel	E298G	0.06
OV	chr14	22928568	Missense_Mutation	novel	E53G	0.03
PAAD	chr14	22929194	Intron	novel		0.16
PRAD	chr14	22929183	Intron	NA		0.31
PRAD	chr14	22926806	Missense_Mutation	novel	M153I	0.52
SARC	chr14	22920610	3'UTR	rs768304949		0.16
SARC	chr14	22924182	Missense_Mutation	novel	L401I	0.09
SKCM	chr14	22924481	Splice_Region	novel	V358V	0.32
SKCM	chr14	22929388	5'UTR	rs534825129		0.77
SKCM	chr14	22924345	Missense_Mutation	NA	S375F	0.19
SKCM	chr14	22927533	Missense_Mutation	NA	S148F	0.29
SKCM	chr14	22928143	Missense_Mutation	NA	R100C	0.06
SKCM	chr14	22929349	Missense_Mutation	NA	A5T	0.48
SKCM	chr14	22920843	3'UTR	novel		0.35
SKCM	chr14	22926276	Missense_Mutation	novel	L212F	0.38
SKCM	chr14	22926277	Silent	novel	D211D	0.38
SKCM	chr14	22926180	Missense_Mutation	NA	P244S	0.19
SKCM	chr14	22924345	Missense_Mutation	NA	S375F	0.34
SKCM	chr14	22920865	3'UTR	novel		0.16
SKCM	chr14	22924345	Missense_Mutation	NA	S375F	0.45
SKCM	chr14	22923126	Silent	NA	S470S	0.19
SKCM	chr14	22923127	Missense_Mutation	NA	S470F	0.65
SKCM	chr14	22923127	Missense_Mutation	NA	S470F	0.33
SKCM	chr14	22927615	Missense_Mutation	novel	A121T	0.2
SKCM	chr14	22924018	Silent	NA	H455H	0.18
SKCM	chr14	22928611	Missense_Mutation	novel	D39N	0.11
STAD	chr14	22922510	Missense_Mutation	novel	E543D	0.15
STAD	chr14	22922831	Missense_Mutation	NA	Q497R	0.42
STAD	chr14	22928524	Nonsense_Mutation	rs374788457	R68*	0.07
STAD	chr14	22924174	Silent	NA	N403N	0.18
THYM	chr14	22926710	Silent	rs759956527	T185T	0.29
UCEC	chr14	22920743	3'UTR	novel		0.32
UCEC	chr14	22929269	Silent	novel	G31G	0.09
UCEC	chr14	22928181	Missense_Mutation	NA	S87Y	0.35
UCEC	chr14	22920850	3'UTR	novel		0.37
UCEC	chr14	22924977	Missense_Mutation	novel	L281I	0.1
UCEC	chr14	22924269	Splice_Site	NA	X400_splice	0.51
UCEC	chr14	22924634	Nonsense_Mutation	novel	Q339*	0.42
UCEC	chr14	22927573	Missense_Mutation	novel	A135T	0.05
UCEC	chr14	22923129	Silent	NA	T469T	0.04
UCEC	chr14	22922242	Splice_Site	NA	X566_splice	0.57
UCEC	chr14	22920897	3'UTR	rs752404648		0.1
UCEC	chr14	22929191	Intron	novel		0.09
UCEC	chr14	22928169	Missense_Mutation	rs757013591	R91H	0.24
UCEC	chr14	22920648	3'UTR	novel		0.54
UCEC	chr14	22928564	Missense_Mutation	novel	F54L	0.31
UCEC	chr14	22924325	Missense_Mutation	novel	A382T	0.28
UCEC	chr14	22924045	Silent	rs749432721	S446S	0.32
UCEC	chr14	22926701	Splice_Site	novel	X188_splice	0.31
UCEC	chr14	22926176	Missense_Mutation	NA	V245A	0.21
UCEC	chr14	22924373	Missense_Mutation	NA	A366T	0.11
UCEC	chr14	22926780	Missense_Mutation	novel	D162G	0.31
UCEC	chr14	22922750	Missense_Mutation	novel	P524L	0.52
UCEC	chr14	22929222	Intron	rs758852744		0.38
UCEC	chr14	22922538	Missense_Mutation	rs754873481	R534H	0.35
UCEC	chr14	22920626	3'UTR	novel		0.23
UCEC	chr14	22928202	Missense_Mutation	NA	T80M	0.39
UCEC	chr14	22924179	Missense_Mutation	NA	E402Q	0.42
UCEC	chr14	22920708	3'UTR	novel		0.5
UCEC	chr14	22924154	Missense_Mutation	novel	G410E	0.49
UCEC	chr14	22928164	Missense_Mutation	novel	D93N	0.3
UCEC	chr14	22924318	Missense_Mutation	novel	R384Q	0.17
UCEC	chr14	22920843	3'UTR	novel		0.47
UCEC	chr14	22928179	Missense_Mutation	novel	P88T	0.21
UCEC	chr14	22920909	Missense_Mutation	NA	L637I	0.13
UCEC	chr14	22926297	Splice_Site	NA	X205_splice	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2667	0.056464
ACC	DEL	0.1556	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1207	0.0025503
KIRP	DEL	0.1667	0.085174
LUSC	DEL	0.2615	0.0082553
PAAD	DEL	0.0761	0.11332

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
ACC	0.00045	Kaplan-Meier Survival Analysis
HNSC	0.00028	Kaplan-Meier Survival Analysis
PAAD	0.0002	Kaplan-Meier Survival Analysis
PCPG	0.036	Kaplan-Meier Survival Analysis
BLCA	0.00072	Kaplan-Meier Survival Analysis
CESC	0.013	Kaplan-Meier Survival Analysis
GBM	0.0049	Kaplan-Meier Survival Analysis
LIHC	0.00064	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000100462 (Gene tree)
Gene ID: 10419
Gene Symbol: PRMT5
Alias: SKB1Hs|HRMT1L5|SKB1
Full Name: protein arginine methyltransferase 5
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 9,075 bases
Position: chr14:22,920,511-22,929,585
Accession: 10894
Summary: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27577262	Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells.	Sci Signal	2016 Aug 30	Larsen SC	doi: 10.1126/scisignal.aaf7329.
21081503	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	J Biol Chem	2011 Jan 21	Guderian G	doi: 10.1074/jbc.M110.148486
28972166	Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule-nucleating protein G3BP1.	J Biol Chem	2017 Nov 17	Tsai WC	doi: 10.1074/jbc.M117.800706
19520849	Role of pICLn in methylation of Sm proteins by PRMT5.	J Biol Chem	2009 Aug 7	Pesiridis GS	doi: 10.1074/jbc.M109.015578
19234465	PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.	Nat Struct Mol Biol	2009 Mar	Zhao Q	doi: 10.1038/nsmb.1568
28236308	PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.	Hepatology	2017 Aug	Zhang W	doi: 10.1002/hep.29133
29920217	Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation.	FASEB J	2018 Jun 19:fj201800244RR	Yang CY	doi: 10.1096/fj.201800244RR

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000476175	PRMT5-207	682	-	-	- (aa)	-	-
ENST00000557758	PRMT5-227	597	-	-	- (aa)	-	-
ENST00000554716	PRMT5-215	561	-	-	- (aa)	-	-
ENST00000553915	PRMT5-214	1931	-	ENSP00000451127	69 (aa)	-	G3V3A3
ENST00000556032	PRMT5-220	643	-	-	- (aa)	-	-
ENST00000554910	PRMT5-217	577	-	ENSP00000452411	169 (aa)	-	G3V5L5
ENST00000557443	PRMT5-226	337	-	ENSP00000452501	61 (aa)	-	H0YJY6
ENST00000556426	PRMT5-222	563	-	-	- (aa)	-	-
ENST00000553550	PRMT5-210	580	-	ENSP00000450737	183 (aa)	-	G3V2L6
ENST00000553641	PRMT5-211	800	-	-	- (aa)	-	-
ENST00000553417	PRMT5-208	259	-	-	- (aa)	-	-
ENST00000553787	PRMT5-212	579	-	ENSP00000452102	42 (aa)	-	G3V507
ENST00000397440	PRMT5-203	1907	-	ENSP00000380582	466 (aa)	-	O14744
ENST00000397441	PRMT5-204	2418	-	ENSP00000380583	620 (aa)	-	O14744
ENST00000557015	PRMT5-224	628	-	-	- (aa)	-	-
ENST00000553897	PRMT5-213	1857	-	ENSP00000452555	593 (aa)	-	O14744
ENST00000421938	PRMT5-205	565	-	ENSP00000409482	186 (aa)	-	C9JSX3
ENST00000556616	PRMT5-223	571	-	ENSP00000450919	185 (aa)	-	G3V2X6
ENST00000627278	PRMT5-228	129	-	ENSP00000485787	42 (aa)	-	G3V507
ENST00000554867	PRMT5-216	555	-	ENSP00000452218	180 (aa)	-	G3V580
ENST00000216350	PRMT5-201	2271	-	ENSP00000216350	576 (aa)	-	O14744
ENST00000555454	PRMT5-218	771	-	ENSP00000451245	177 (aa)	-	H0YJD3
ENST00000557415	PRMT5-225	584	-	ENSP00000450633	86 (aa)	-	G3V2F5
ENST00000324366	PRMT5-202	2531	-	ENSP00000319169	637 (aa)	-	O14744
ENST00000556043	PRMT5-221	603	-	ENSP00000452509	104 (aa)	-	G3V5T6
ENST00000454731	PRMT5-206	617	-	ENSP00000387663	179 (aa)	-	H7BZ44
ENST00000555530	PRMT5-219	837	-	ENSP00000452409	279 (aa)	-	H0YJX6
ENST00000553502	PRMT5-209	414	-	ENSP00000450956	138 (aa)	-	H0YJ77

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100462's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000387	spliceosomal snRNP assembly	17709427.	IMP	Process
GO:0000387	spliceosomal snRNP assembly	-	TAS	Process
GO:0003714	transcription corepressor activity	-	ISS	Function
GO:0005515	protein binding	11756452.16087681.18404153.18984161.19234465.20133701.20159986.20421892.20810653.20951943.21081503.22269951.22327218.22365833.23071334.23455924.23892143.25092918.25284789.25852190.26700805.26763441.26912361.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21081503.	IDA	Component
GO:0005634	nucleus	18404153.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	22952863.	IDA	Component
GO:0005794	Golgi apparatus	20421892.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	18984161.21081503.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006353	DNA-templated transcription, termination	26700805.	IMP	Process
GO:0007088	regulation of mitotic nuclear division	9843966.	TAS	Process
GO:0008168	methyltransferase activity	15369763.	IDA	Function
GO:0008283	cell proliferation	9843966.	TAS	Process
GO:0008327	methyl-CpG binding	25284789.	IDA	Function
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0008469	histone-arginine N-methyltransferase activity	-	TAS	Function
GO:0016274	protein-arginine N-methyltransferase activity	20421892.26554819.	IDA	Function
GO:0018216	peptidyl-arginine methylation	17709427.	IMP	Process
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine	-	IEA	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0034709	methylosome	18984161.25284789.	IDA	Component
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0035097	histone methyltransferase complex	23048031.	IDA	Component
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	19011621.	EXP	Function
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	17709427.	IMP	Function
GO:0035246	peptidyl-arginine N-methylation	15369763.26554819.	IDA	Process
GO:0042118	endothelial cell activation	22269951.	IMP	Process
GO:0042802	identical protein binding	11756452.22365833.23071334.	IPI	Function
GO:0043021	ribonucleoprotein complex binding	17709427.	IPI	Function
GO:0043985	histone H4-R3 methylation	-	ISS	Process
GO:0043985	histone H4-R3 methylation	18404153.	NAS	Process
GO:0044020	histone methyltransferase activity (H4-R3 specific)	25284789.	IMP	Function
GO:0044030	regulation of DNA methylation	-	IEA	Process
GO:0045596	negative regulation of cell differentiation	-	IEA	Process
GO:0046982	protein heterodimerization activity	18495660.	IDA	Function
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	Process
GO:0070372	regulation of ERK1 and ERK2 cascade	-	IEA	Process
GO:0070888	E-box binding	-	ISS	Function
GO:0090161	Golgi ribbon formation	20421892.	IMP	Process
GO:0097421	liver regeneration	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1904992	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	26554819.	IGI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.