EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26459911The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.Sci Rep2015 Oct 13Zhu Mdoi: 10.1038/srep14969.
27650891The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.Nat Commun2016 Sep 21Starrett GJdoi: 10.1038/ncomms12918.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2239101346Missense_MutationnovelS87F0.15
BLCAchr2239101347Silentrs773083408S87S0.15
BLCAchr2239101247Missense_MutationnovelH54R0.15
BLCAchr2239101384Missense_MutationnovelD100N0.38
CESCchr2239101351Missense_MutationNAA89S0.11
CESCchr2239101915Splice_Regionnovel0.23
COADchr2239100296Silentrs539789572A6A0.17
COADchr2239100304Missense_MutationNAF9S0.36
COADchr2239101294Missense_MutationNAE70K0.5
COADchr2239100386SilentnovelP36P0.22
COADchr2239101927Missense_MutationnovelD143G0.3
ESCAchr2239101270Missense_Mutationrs766612664E62K0.14
GBMchr22391037013'UTRnovel0.06
GBMchr2239101286Missense_MutationnovelG67E0.42
GBMchr2239101960Missense_MutationNAP154L0.41
HNSCchr2239101286Missense_MutationnovelG67E0.28
HNSCchr2239101500Silentrs775553421F138F0.21
LGGchr2239101960Missense_MutationNAP154L0.79
LGGchr2239101433Missense_MutationnovelC116Y0.19APOBEC_N
LIHCchr2239101457Missense_Mutationrs374311513R124Q0.45APOBEC_N
LUADchr2239102043Splice_Siters368222781X181_splice0.55
LUADchr2239101931Frame_Shift_InsnovelW145Lfs*170.35
LUADchr2239101377Missense_MutationNAK97N0.18
LUSCchr2239100307Missense_MutationNAR10L0.39
LUSCchr2239100330Missense_MutationnovelR18C0.46
PAADchr22391038723'UTRnovel0.08
SKCMchr2239101334Missense_MutationNAS83N0.35
SKCMchr2239102011Missense_MutationNAR171Q0.16
SKCMchr2239101940Missense_MutationNAN147K0.18
SKCMchr2239101396SilentNAL104L0.33
SKCMchr2239101332Nonsense_MutationNAW82*0.36
SKCMchr2239101934Nonsense_MutationnovelW145*0.36
SKCMchr22391037033'UTRnovel0.32
STADchr2239100361Missense_MutationNAA28V0.12
UCECchr2239100411Missense_MutationnovelG45C0.21
UCECchr2239100363Missense_MutationnovelL29I0.07
UCECchr2239101936Missense_MutationnovelE146G0.3
UCECchr2239100406Missense_Mutationrs769176395T43M0.09
UCECchr2239102528Missense_Mutationrs552952015A187V0.41
UCECchr22391037373'UTRnovel0.26
UCECchr2239100305SilentnovelF9F0.15
UCECchr2239102014Missense_MutationnovelA172V0.6
UCECchr2239101270Missense_Mutationrs766612664E62K0.19
UCECchr22391038583'UTRnovel0.6
UCECchr2239101961Silentrs147418182P154P0.36
UCECchr2239102025Missense_MutationNAR176W0.39
UCECchr2239100307Missense_Mutationrs372088508R10H0.33
UCECchr2239102030SilentnovelL177L0.06
UCECchr22391038063'UTRnovel0.06
UCECchr2239102022Nonsense_Mutationrs535832435R175*0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PCPGDEL0.31480.044123
THCADEL0.15630.046486
THYMDEL0.08130.063154

Survival Analysis
CancerP-value Q-value
THYM0.0039

Kaplan-Meier Survival Analysis

KIRC0.00031

Kaplan-Meier Survival Analysis

SARC0.0051

Kaplan-Meier Survival Analysis

ACC0.046

Kaplan-Meier Survival Analysis

HNSC0.004

Kaplan-Meier Survival Analysis

SKCM0.00011

Kaplan-Meier Survival Analysis

BRCA0.019

Kaplan-Meier Survival Analysis

BLCA0.0001

Kaplan-Meier Survival Analysis

CESC0.00049

Kaplan-Meier Survival Analysis

LAML0.0071

Kaplan-Meier Survival Analysis

UCEC0.00074

Kaplan-Meier Survival Analysis

LIHC0.034

Kaplan-Meier Survival Analysis

LGG0.00095

Kaplan-Meier Survival Analysis

CHOL0.031

Kaplan-Meier Survival Analysis

THCA0.015

Kaplan-Meier Survival Analysis

LUAD0.0033

Kaplan-Meier Survival Analysis

UVM0.016

Kaplan-Meier Survival Analysis

OV0.012

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000100298 (Gene tree)
Gene ID
164668
Gene Symbol
APOBEC3H
Alias
ARP10
Full Name
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
6,845 bases
Position
chr22:39,097,223-39,104,067
Accession
24100
RBP type
canonical RBP
Summary
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000216123APOBEC_NPF08210.114.4e-3511
ENSP00000411754APOBEC_NPF08210.114.5e-3511
ENSP00000385741APOBEC_NPF08210.116.2e-3511
ENSP00000483689APOBEC_NPF08210.116.2e-3511
ENSP00000393520APOBEC_NPF08210.113.8e-2711
ENSP00000482682APOBEC_NPF08210.113.8e-2711
ENSP00000216123APOBEC_CPF05240.141.5e-2411
ENSP00000411754APOBEC_CPF05240.141.5e-2411
ENSP00000385741APOBEC_CPF05240.141.9e-2411
ENSP00000483689APOBEC_CPF05240.141.9e-2411
ENSP00000393520APOBEC_CPF05240.141.1e-0911
ENSP00000482682APOBEC_CPF05240.141.1e-0911

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29044109APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.Nat Commun2017 Oct 18Bohn JAdoi: 10.1038/s41467-017-01309-6.
22859935Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities.PLoS One2012Zhen Adoi: 10.1371/journal.pone.0038771
27541140The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid.PLoS Pathog2016 Aug 19York Adoi: 10.1371/journal.ppat.1005833
29290613The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.Mol Cell2018 Jan 4Shaban NMdoi: 10.1016/j.molcel.2017.12.010
30414963RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.J Mol Biol2018 Dec 7Feng Ydoi: 10.1016/j.jmb.2018.11.006
30679582A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes.Sci Rep2019 Jan 24Martin ASdoi: 10.1038/s41598-018-36739-9.
29491387Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.Sci Rep2018 Feb 28Ito Fdoi: 10.1038/s41598-018-21955-0.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000613996APOBEC3H-207465-ENSP00000482682154 (aa)-A0A087WZI3
ENST00000401756APOBEC3H-2021023XM_011529990ENSP00000385741200 (aa)XP_011528292Q6NTF7
ENST00000421988APOBEC3H-203592-ENSP00000393520154 (aa)-Q6NTF7
ENST00000474235APOBEC3H-205338--- (aa)--
ENST00000613677APOBEC3H-206730-ENSP00000483689200 (aa)-UPI000188E67A
ENST00000348946APOBEC3H-2011046-ENSP00000216123182 (aa)-Q6NTF7
ENST00000442487APOBEC3H-204988-ENSP00000411754183 (aa)-Q6NTF7
Gene Model
Click here to download ENSG00000100298's gene model file
Pathways
Pathway IDPathway NameSource
hsa05170Human immunodeficiency virus 1 infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100298's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000100298APOBEC3H9933.163ENSG00000179750APOBEC3B9032.911
ENSG00000100298APOBEC3H9934.759ENSG00000128394APOBEC3F8836.025
ENSG00000100298APOBEC3H7441.045ENSG00000244509APOBEC3C7140.288
ENSG00000100298APOBEC3H9733.862ENSG00000239713APOBEC3G9233.161
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000100298APOBEC3H10046.486ENSAMEG00000010818-7646.486Ailuropoda_melanoleuca
ENSG00000100298APOBEC3H10072.581ENSANAG00000025410APOBEC3H8370.811Aotus_nancymaae
ENSG00000100298APOBEC3H9948.889ENSBTAG00000007755APOBEC3H9248.889Bos_taurus
ENSG00000100298APOBEC3H10072.078ENSCJAG00000012524APOBEC3H10069.481Callithrix_jacchus
ENSG00000100298APOBEC3H9946.703ENSCAFG00000001361APOBEC3Z39345.604Canis_familiaris
ENSG00000100298APOBEC3H9946.154ENSCAFG00020002584-9645.026Canis_lupus_dingo
ENSG00000100298APOBEC3H9950.000ENSCHIG00000026580-9550.000Capra_hircus
ENSG00000100298APOBEC3H9851.124ENSTSYG00000032894-10051.124Carlito_syrichta
ENSG00000100298APOBEC3H10052.486ENSCPOG00000009257-8652.809Cavia_porcellus
ENSG00000100298APOBEC3H10074.522ENSCCAG00000008525APOBEC3H10073.885Cebus_capucinus
ENSG00000100298APOBEC3H10082.500ENSCATG00000030302APOBEC3H10082.500Cercocebus_atys
ENSG00000100298APOBEC3H9853.333ENSCLAG00000016615-8853.333Chinchilla_lanigera
ENSG00000100298APOBEC3H10080.874ENSCSAG00000006371APOBEC3H8780.874Chlorocebus_sabaeus
ENSG00000100298APOBEC3H10049.462ENSCGRG00001022976Apobec38449.462Cricetulus_griseus_chok1gshd
ENSG00000100298APOBEC3H10049.462ENSCGRG00000005621Apobec38449.462Cricetulus_griseus_crigri
ENSG00000100298APOBEC3H9950.811ENSDORG00000027271-9942.857Dipodomys_ordii
ENSG00000100298APOBEC3H9852.809ENSECAG00000007726APOBEC3H7552.809Equus_caballus
ENSG00000100298APOBEC3H9950.556ENSFCAG00000005251APOBEC3Z39350.273Felis_catus
ENSG00000100298APOBEC3H9951.111ENSSTOG00000007125-8551.111Ictidomys_tridecemlineatus
ENSG00000100298APOBEC3H9748.529ENSJJAG00000016840-7348.529Jaculus_jaculus
ENSG00000100298APOBEC3H10051.124ENSLAFG00000027404-9551.124Loxodonta_africana
ENSG00000100298APOBEC3H10083.766ENSMFAG00000031827APOBEC3H10083.766Macaca_fascicularis
ENSG00000100298APOBEC3H10084.416ENSMMUG00000001016APOBEC3H10084.416Macaca_mulatta
ENSG00000100298APOBEC3H10083.766ENSMNEG00000039259APOBEC3H10083.766Macaca_nemestrina
ENSG00000100298APOBEC3H10084.416ENSMLEG00000033417APOBEC3H10084.416Mandrillus_leucophaeus
ENSG00000100298APOBEC3H10048.128ENSMAUG00000011683Apobec37247.568Mesocricetus_auratus
ENSG00000100298APOBEC3H9948.901ENSMOCG00000021576Apobec38348.333Microtus_ochrogaster
ENSG00000100298APOBEC3H10048.108MGP_CAROLIEiJ_G0020029Apobec39247.568Mus_caroli
ENSG00000100298APOBEC3H9947.590ENSMUSG00000009585Apobec39943.434Mus_musculus
ENSG00000100298APOBEC3H10048.936MGP_PahariEiJ_G0020031-8647.340Mus_pahari
ENSG00000100298APOBEC3H10047.027MGP_SPRETEiJ_G0020927Apobec39838.095Mus_spretus
ENSG00000100298APOBEC3H9948.333ENSMPUG00000013239-7848.333Mustela_putorius_furo
ENSG00000100298APOBEC3H10048.333ENSNGAG00000018998Apobec39348.333Nannospalax_galili
ENSG00000100298APOBEC3H10087.978ENSNLEG00000015218-8787.978Nomascus_leucogenys
ENSG00000100298APOBEC3H9840.223ENSOCUG00000023913-8140.223Oryctolagus_cuniculus
ENSG00000100298APOBEC3H9949.444ENSOARG00000016290APOBEC3F9649.444Ovis_aries
ENSG00000100298APOBEC3H10095.455ENSPPAG00000036522APOBEC3H10095.455Pan_paniscus
ENSG00000100298APOBEC3H9951.381ENSPPRG00000003941-9350.543Panthera_pardus
ENSG00000100298APOBEC3H9235.260ENSPPRG00000003675-8834.682Panthera_pardus
ENSG00000100298APOBEC3H9951.381ENSPTIG00000010283-9350.543Panthera_tigris_altaica
ENSG00000100298APOBEC3H10095.455ENSPTRG00000014390APOBEC3H10095.455Pan_troglodytes
ENSG00000100298APOBEC3H10084.066ENSPANG00000010774APOBEC3H9983.660Papio_anubis
ENSG00000100298APOBEC3H10045.161ENSPEMG00000000456Apobec37644.624Peromyscus_maniculatus_bairdii
ENSG00000100298APOBEC3H10088.525ENSPPYG00000011834-8788.525Pongo_abelii
ENSG00000100298APOBEC3H9842.135ENSPCAG00000015655-9941.111Procavia_capensis
ENSG00000100298APOBEC3H7037.008ENSPVAG00000024267-9337.008Pteropus_vampyrus
ENSG00000100298APOBEC3H9851.124ENSPVAG00000009462-9851.124Pteropus_vampyrus
ENSG00000100298APOBEC3H7037.008ENSPVAG00000024161-9337.008Pteropus_vampyrus
ENSG00000100298APOBEC3H10048.663ENSRNOG00000016852Apobec38748.663Rattus_norvegicus
ENSG00000100298APOBEC3H10081.967ENSRBIG00000029088APOBEC3H10081.818Rhinopithecus_bieti
ENSG00000100298APOBEC3H10081.421ENSRROG00000024699APOBEC3H10081.000Rhinopithecus_roxellana
ENSG00000100298APOBEC3H9970.492ENSSBOG00000030005APOBEC3H10069.504Saimiri_boliviensis_boliviensis
ENSG00000100298APOBEC3H9950.556ENSSSCG00000000091APOBEC3B8350.556Sus_scrofa
ENSG00000100298APOBEC3H9550.000ENSTBEG00000001532-9850.000Tupaia_belangeri
ENSG00000100298APOBEC3H10051.099ENSTTRG00000001266-10051.099Tursiops_truncatus
ENSG00000100298APOBEC3H9947.872ENSUAMG00000004427-8347.872Ursus_americanus
ENSG00000100298APOBEC3H9950.829ENSUMAG00000014435-9150.829Ursus_maritimus
ENSG00000100298APOBEC3H7151.538ENSVPAG00000011108-9851.538Vicugna_pacos
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000932P-body22915799.IDAComponent
GO:0003723RNA binding21873635.IBAFunction
GO:0004126cytidine deaminase activity21873635.IBAFunction
GO:0004126cytidine deaminase activity16571802.IDAFunction
GO:0005515protein binding22915799.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus18779051.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm18779051.21835787.IDAComponent
GO:0008270zinc ion binding-IEAFunction
GO:0009972cytidine deamination-IEAProcess
GO:0010529negative regulation of transposition18779051.20062055.IDAProcess
GO:0010529negative regulation of transposition18827027.IMPProcess
GO:0016554cytidine to uridine editing21873635.IBAProcess
GO:0045087innate immune response-IEAProcess
GO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate18779051.21835787.IDAProcess
GO:0048525negative regulation of viral process18827027.IMPProcess
GO:0051607defense response to virus21835787.22457529.22915799.IDAProcess
GO:0070383DNA cytosine deamination16571802.21835787.IDAProcess
GO:0080111DNA demethylation21873635.IBAProcess
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