EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24389200Downregulation of CRKL expression can inhibit tumorigenesis in colon cancer.Front Biosci (Landmark Ed)2014 Jan 1Lan B-
25476480CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways.Med Oncol2015 JanLian Xdoi: 10.1007/s12032-014-0411-z
21700719CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.Mol Endocrinol2011 SepPadmanabhan RAdoi: 10.1210/me.2011-0008
25318601CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.Tumour Biol2015 FebFu Ldoi: 10.1007/s13277-014-2706-2
22591714The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.J Transl Med2012 Jul 3Natsume Hdoi: 10.1186/1479-5876-10-97.
27133071The effects of Micro-429 on inhibition of cervical cancer cells through targeting ZEB1 and CRKL.Biomed Pharmacother2016 MayWang Ydoi: 10.1016/j.biopha.2016.03.035
22569336Crk adaptor proteins act as key signaling integrators for breast tumorigenesis.Breast Cancer Res2012 May 8Fathers KE-
19966867Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.Oncogene2010 Mar 11Kim YHdoi: 10.1038/onc.2009.437
24375195Clinical significance and biological roles of CRKL in human bladder carcinoma.Tumour Biol2014 MayHan Bdoi: 10.1007/s13277-013-1536-y
24939008CRKL amplification is rare as a mechanism for acquired resistance to kinase inhibitors in lung cancers with epidermal growth factor receptor mutation.Lung Cancer2014 AugSuda Kdoi: 10.1016/j.lungcan.2014.05.018
26044596CrkL meditates CCL20/CCR6-induced EMT in gastric cancer.Cytokine2015 DecHan Gdoi: 10.1016/j.cyto.2015.05.009
21319228Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma.Mol Carcinog2011 JulWang Jdoi: 10.1002/mc.20745
27846244SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells.PLoS One2016 Nov 15Wang Jdoi: 10.1371/journal.pone.0166147
27078848CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma.Oncotarget2016 May 17An Rdoi: 10.18632/oncotarget.8638.
28723560CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.Cell Rep2017 Jul 18Zhang Jdoi: 10.1016/j.celrep.2017.06.054.
29295725MicroRNA-379 Suppresses Cervical Cancer Cell Proliferation and Invasion by Directly Targeting V-crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like (CRKL).Oncol Res2018 Aug 23Shi Xdoi: 10.3727/096504017X15140534417184

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr22209498583'UTRnovel0.08
BLCAchr2220917995Missense_MutationnovelR21C0.43
BLCAchr2220918015SilentNAR27R0.22
BRCAchr2220949773Silentrs769606385N280N0.09
BRCAchr22209574513'Flanknovel0.25
BRCAchr22209499193'UTRnovel0.15
BRCAchr2220918008Missense_MutationNAQ25R0.61
CESCchr22209525003'UTRnovel0.31
CESCchr2220918075Frame_Shift_DelnovelY48Cfs*1010.07
CESCchr2220933810Missense_MutationnovelA115S0.41
COADchr2220933810Missense_MutationnovelA115T0.1
COADchr2220949778Missense_MutationnovelR282H0.26
COADchr2220918070Missense_MutationNAG46W0.23
COADchr2220934081Missense_MutationNAH205R0.27
COADchr2220933901Missense_MutationNAK145T0.26
DLBCchr2220934127Silentrs763765173S220S0.4
ESCAchr2220918211SilentnovelL93L0.29
GBMchr2220934033Missense_MutationnovelK189R0.03
HNSCchr2220918231Missense_MutationnovelI99M0.64
HNSCchr2220949765Missense_MutationNAE278K0.07
KIRPchr22209500193'UTRnovel0.31
KIRPchr2220917971Missense_MutationNAA13P0.18
LGGchr2220934083Missense_MutationnovelA206T0.42
LGGchr2220949800SilentNAT289T0.04
LUADchr2220934139SilentnovelG224G0.27
LUADchr2220934140Missense_MutationnovelA225S0.27
LUADchr2220918172Missense_MutationnovelH80D0.22
LUADchr2220933858Missense_MutationNAL131V0.11
LUSCchr2220933915SilentNAL150L0.23
LUSCchr2220934238SilentNAA257A0.27
LUSCchr2220934098Missense_MutationNAQ211E0.29
PAADchr2220933884SilentnovelA139A0.06
READchr2220934169SilentNAQ234Q0.21
READchr2220934187Silentrs755185083A240A0.43
READchr2220949765Missense_MutationNAE278K0.15
SKCMchr2220949792Missense_MutationnovelP287S0.34
SKCMchr2220933836SilentnovelD123D0.19
SKCMchr2220933934Missense_MutationNAP156L0.35
SKCMchr2220933965SilentnovelK166K0.14
SKCMchr2220918025Nonsense_MutationnovelQ31*0.21
STADchr2220933879Missense_MutationNAD138Y0.42
STADchr2220933958Missense_Mutationrs200712124R164Q0.13
STADchr2220949773Silentrs769606385N280N0.34
STADchr2220933791SilentNAP108P0.08
STADchr2220918187Silentrs774677048L85L0.22
THCAchr22209500433'UTRnovel0.17
UCECchr2220933928Frame_Shift_InsnovelE158Afs*20.08
UCECchr2220934000Missense_MutationnovelV178A0.15
UCECchr22209524823'UTRnovel0.19
UCECchr2220949765Missense_MutationNAE278K0.29
UCECchr2220934001Silentrs752182830V178V0.44
UCECchr22209529963'UTRrs7490559600.47
UCECchr22209532023'UTRnovel0.48
UCECchr22209537113'UTRnovel0.56
UCECchr2220934138Missense_MutationNAG224V0.47
UCECchr22209535103'UTRnovel0.22
UCECchr2220934029Missense_Mutationrs746219908G188R0.45
UCECchr2220949805Missense_MutationnovelV291A0.42
UCECchr22209179015'UTRnovel0.48
UCECchr2220933840Missense_MutationNAL125M0.24
UCECchr22209498543'UTRnovel0.17
UCECchr22209500513'UTRnovel0.37
UCECchr22209524813'UTRrs1899845910.18
UCECchr22209535813'UTRnovel0.49
UCECchr2220949800SilentNAT289T0.25
UCECchr2220934100Missense_MutationnovelQ211H0.39
UCECchr22209500313'UTRrs7729592640.56
UCECchr22209529253'UTRnovel0.42
UCECchr2220917993Missense_MutationnovelS20F0.33
UCECchr2220918019Nonsense_MutationNAQ29*0.56
UCECchr22209500513'UTRnovel0.31
UCECchr2220934153Missense_MutationnovelP229H0.5
UCECchr22209523373'UTRnovel0.73
UCECchr2220949800SilentNAT289T0.33
UCECchr2220949804Missense_MutationnovelV291I0.28
UCECchr22209523673'UTRnovel0.3
UCECchr22209526713'UTRnovel0.36
UCECchr22209532153'UTRnovel0.37
UCECchr2220949800SilentNAT289T0.31
UCECchr2220933841Missense_MutationnovelL125P0.34
UCECchr2220933782Nonsense_MutationnovelY105*0.19
UCECchr2220949773Silentrs769606385N280N0.13
UCECchr2220934001Silentrs752182830V178V0.21
UCECchr2220949799Missense_MutationNAT289M0.3
UCECchr2220933934Missense_MutationNAP156H0.33
UCECchr2220933834Missense_MutationnovelD123Y0.27
UCECchr22209531583'UTRnovel0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LUSCAMP0.38922.9109e-05
LUSCDEL0.11780.0093511
TGCTAMP0.35335.309e-06
THCAAMP0.0080.056221

Survival Analysis
CancerP-value Q-value
THYM0.016

Kaplan-Meier Survival Analysis

KIRC0.023

Kaplan-Meier Survival Analysis

STAD0.02

Kaplan-Meier Survival Analysis

SARC0.032

Kaplan-Meier Survival Analysis

ACC0.0026

Kaplan-Meier Survival Analysis

SKCM0.044

Kaplan-Meier Survival Analysis

KIRP0.0037

Kaplan-Meier Survival Analysis

BLCA0.016

Kaplan-Meier Survival Analysis

READ0.0057

Kaplan-Meier Survival Analysis

LAML0.049

Kaplan-Meier Survival Analysis

KICH0.037

Kaplan-Meier Survival Analysis

UCEC0.029

Kaplan-Meier Survival Analysis

LIHC0.024

Kaplan-Meier Survival Analysis

LGG0.00048

Kaplan-Meier Survival Analysis

UVM0.049

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000099942 (Gene tree)
Gene ID
1399
Gene Symbol
CRKL
Alias
N
Full Name
CRK like proto-oncogene, adaptor protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
36,352 bases
Position
chr22:20,917,398-20,953,749
Accession
2363
RBP type
non-canonical RBP
Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000411769CRKL-2022037-ENSP00000396646303 (aa)-P46109
ENST00000354336CRKL-2015325-ENSP00000346300303 (aa)-P46109
Gene Model
Click here to download ENSG00000099942's gene model file
Pathways
Pathway IDPathway NameSource
hsa04010MAPK signaling pathwayKEGG
hsa04012ErbB signaling pathwayKEGG
hsa04015Rap1 signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04666Fc gamma R-mediated phagocytosisKEGG
hsa04722Neurotrophin signaling pathwayKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04910Insulin signaling pathwayKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05131ShigellosisKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
hsa05211Renal cell carcinomaKEGG
hsa05220Chronic myeloid leukemiaKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000099942rs1394599462220925144TPlatelet distribution width27863252[0.13-0.23] unit decrease0.1828325EFO_0007984
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099942's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000186activation of MAPKK activity-TASProcess
GO:0000187activation of MAPK activity-IEAProcess
GO:0001558regulation of cell growth-IEAProcess
GO:0001568blood vessel development-IEAProcess
GO:0001655urogenital system development-IEAProcess
GO:0001764neuron migration-IEAProcess
GO:0001783B cell apoptotic process-IEAProcess
GO:0001784phosphotyrosine residue binding20624904.IPIFunction
GO:0001933negative regulation of protein phosphorylation23959425.IMPProcess
GO:0001934positive regulation of protein phosphorylation23959425.IMPProcess
GO:0003151outflow tract morphogenesis-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005070SH3/SH2 adaptor activity8798523.TASFunction
GO:0005515protein binding8626543.9546424.9788432.10022120.16273093.16284401.16443220.16982329.17065230.19004829.19168626.22286129.23397142.23770091.24658140.24728074.25241761.25814554.26496610.28086240.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006629lipid metabolic process-IEAProcess
GO:0007254JNK cascade8798523.TASProcess
GO:0007265Ras protein signal transduction8798523.TASProcess
GO:0007283spermatogenesis-IEAProcess
GO:0007338single fertilization-IEAProcess
GO:0007416synapse assembly-IEAProcess
GO:0008284positive regulation of cell proliferation25540073.IMPProcess
GO:0008543fibroblast growth factor receptor signaling pathway-IEAProcess
GO:0008584male gonad development-IEAProcess
GO:0009952anterior/posterior pattern specification-IEAProcess
GO:0010629negative regulation of gene expression23959425.IMPProcess
GO:0016358dendrite development-IEAProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0021766hippocampus development-IEAProcess
GO:0021987cerebral cortex development-IEAProcess
GO:0030010establishment of cell polarity-IEAProcess
GO:0031594neuromuscular junction-IEAComponent
GO:0032991protein-containing complex-IEAComponent
GO:0033628regulation of cell adhesion mediated by integrin-IEAProcess
GO:0035556intracellular signal transduction8361759.TASProcess
GO:0035685helper T cell diapedesis-IEAProcess
GO:0038026reelin-mediated signaling pathway-IEAProcess
GO:0042802identical protein binding17161365.19168626.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0046579positive regulation of Ras protein signal transduction-TASProcess
GO:0048384retinoic acid receptor signaling pathway-IEAProcess
GO:0048538thymus development-IEAProcess
GO:0050773regulation of dendrite development-IEAProcess
GO:0050852T cell receptor signaling pathway-IEAProcess
GO:0060017parathyroid gland development-IEAProcess
GO:0060326cell chemotaxis-IEAProcess
GO:0060465pharynx development-IEAProcess
GO:0070374positive regulation of ERK1 and ERK2 cascade23959425.IMPProcess
GO:0071560cellular response to transforming growth factor beta stimulus23959425.IMPProcess
GO:0086100endothelin receptor signaling pathway-IEAProcess
GO:0090630activation of GTPase activity-IEAProcess
GO:0095500acetylcholine receptor signaling pathway-IEAProcess
GO:0098749cerebellar neuron development-IEAProcess
GO:0098761cellular response to interleukin-7-IEAProcess
GO:0098890extrinsic component of postsynaptic membrane-IEAComponent
GO:1900026positive regulation of substrate adhesion-dependent cell spreading19004829.IMPProcess
GO:1903977positive regulation of glial cell migration23959425.IMPProcess
GO:1904393regulation of skeletal muscle acetylcholine-gated channel clustering-IEAProcess
GO:1904888cranial skeletal system development-IEAProcess
GO:2000404regulation of T cell migration-IEAProcess
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