EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23108393	Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.	Oncogene	2013 Sep 19	Amato R	doi: 10.1038/onc.2012.470

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	20119043	Nonsense_Mutation	novel	E16*	0.32
BLCA	chr22	20127102	3'UTR	novel		0.27
BLCA	chr22	20122351	Missense_Mutation	novel	H80Q	0.33
BRCA	chr22	20126349	Silent	rs769969249	I162I	0.25
BRCA	chr22	20127098	3'UTR	rs775387952		0.21
CESC	chr22	20127181	3'UTR	novel		0.59
CESC	chr22	20116426	5'Flank	novel		0.41
CESC	chr22	20127160	3'UTR	novel		0.37
COAD	chr22	20122333	Silent	NA	D74D	0.42
COAD	chr22	20125337	Missense_Mutation	rs771917916	A114T	0.28
COAD	chr22	20127091	3'UTR	rs781574041		0.37
COAD	chr22	20126340	Missense_Mutation	NA	R159S	0.47
COAD	chr22	20127102	3'UTR	novel		0.12
COAD	chr22	20127052	Nonstop_Mutation	NA	202Yext16	0.33
ESCA	chr22	20122303	Silent	novel	L64L	0.35
GBM	chr22	20122406	Missense_Mutation	novel	C99R	0.7
GBM	chr22	20126337	Silent	novel	C158C	0.08
KIRP	chr22	20122320	Missense_Mutation	novel	R70Q	0.15
KIRP	chr22	20122331	Missense_Mutation	novel	D74Y	0.36
LGG	chr22	20122269	Missense_Mutation	novel	A53V	0.35
LIHC	chr22	20127065	3'UTR	novel		0.25
LUAD	chr22	20122281	Missense_Mutation	NA	R57Q	0.09
LUSC	chr22	20119119	Missense_Mutation	novel	L41R	0.05
LUSC	chr22	20127081	3'UTR	novel		0.21
OV	chr22	20119102	Missense_Mutation	novel	E35D	0.83
OV	chr22	20119034	Missense_Mutation	novel	T13A	0.06
PAAD	chr22	20125413	Missense_Mutation	novel	A139V	0.22
PRAD	chr22	20127056	3'UTR	rs536566752		0.48
READ	chr22	20126332	Nonsense_Mutation	NA	E157*	0.51
SKCM	chr22	20126976	Missense_Mutation	NA	A177V	0.44
SKCM	chr22	20127055	3'UTR	novel		0.23
SKCM	chr22	20122375	Silent	NA	L88L	0.13
UCEC	chr22	20122265	Missense_Mutation	novel	R52W	0.19
UCEC	chr22	20127046	Silent	novel	K200K	0.22
UCEC	chr22	20119126	Silent	novel	E43E	0.32
UCEC	chr22	20126979	Missense_Mutation	rs756772977	E178G	0.28
UCEC	chr22	20126349	Silent	rs769969249	I162I	0.44
UCEC	chr22	20116421	5'Flank	novel		0.43
UCEC	chr22	20119071	Missense_Mutation	NA	P25R	0.19
UCEC	chr22	20126349	Silent	rs769969249	I162I	0.43
UCEC	chr22	20122370	Missense_Mutation	novel	R87C	0.18
UCEC	chr22	20127052	Nonstop_Mutation	NA	202Yext16	0.32
UCEC	chr22	20127091	3'UTR	novel		0.52
UCEC	chr22	20119081	Silent	novel	E28E	0.17
UCEC	chr22	20126317	Frame_Shift_Del	novel	*T153Qfs32**	0.39
UCEC	chr22	20119045	Missense_Mutation	NA	E16D	0.32
UCEC	chr22	20127071	3'UTR	novel		0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUSC	AMP	0.3892	2.9109e-05
LUSC	DEL	0.1178	0.0093511
TGCT	AMP	0.3533	5.309e-06
THCA	AMP	0.008	0.056221

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0084	Kaplan-Meier Survival Analysis
KIRC	0.0013	Kaplan-Meier Survival Analysis
STAD	0.0084	Kaplan-Meier Survival Analysis
SARC	0.0038	Kaplan-Meier Survival Analysis
MESO	0.041	Kaplan-Meier Survival Analysis
ACC	0.00019	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
SKCM	0.014	Kaplan-Meier Survival Analysis
LUSC	0.00084	Kaplan-Meier Survival Analysis
PAAD	0.022	Kaplan-Meier Survival Analysis
PCPG	0.032	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
UCEC	0.022	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.025	Kaplan-Meier Survival Analysis
LGG	0.024	Kaplan-Meier Survival Analysis
LUAD	0.0035	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000099901 (Gene tree)
Gene ID: 5902
Gene Symbol: RANBP1
Alias: HTF9A
Full Name: RAN binding protein 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 11,420 bases
Position: chr22:20,115,938-20,127,357
Accession: 9847
Summary: This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000432879	RANBP1-209	744	-	ENSP00000404724	165 (aa)	-	C9JDM3
ENST00000423859	RANBP1-207	832	XM_017028891	ENSP00000404298	204 (aa)	XP_016884380	C9JGV6
ENST00000435265	RANBP1-210	1879	-	ENSP00000390139	73 (aa)	-	F8WCY3
ENST00000488484	RANBP1-214	699	-	-	- (aa)	-	-
ENST00000418705	RANBP1-205	932	XM_011530291	ENSP00000413502	145 (aa)	XP_011528593	C9JXG8
ENST00000421656	RANBP1-206	333	-	ENSP00000400940	53 (aa)	-	C9JIC6
ENST00000402752	RANBP1-202	1132	XM_011530290	ENSP00000384925	200 (aa)	XP_011528592	P43487
ENST00000416427	RANBP1-204	645	-	ENSP00000404126	53 (aa)	-	C9JIC6
ENST00000430524	RANBP1-208	1389	-	ENSP00000401564	278 (aa)	-	F6WQW2
ENST00000411892	RANBP1-203	584	XM_011530289	ENSP00000395472	163 (aa)	XP_011528591	C9JJ34
ENST00000448394	RANBP1-211	688	-	-	- (aa)	-	-
ENST00000486575	RANBP1-213	2177	-	-	- (aa)	-	-
ENST00000331821	RANBP1-201	837	-	ENSP00000327583	201 (aa)	-	P43487
ENST00000467920	RANBP1-212	529	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa05166	Human T-cell leukemia virus 1 infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099901's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000099901	RANBP1	100	98.113	ENSMUSG00000005732	Ranbp1	98	94.975	Mus_musculus
ENSG00000099901	RANBP1	98	69.231	YDR002W	YRB1	77	53.797	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005092	GDP-dissociation inhibitor activity	7616957.	IMP	Function
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005515	protein binding	7616957.16428860.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16130169.	TAS	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	25743254.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007165	signal transduction	16130169.	TAS	Process
GO:0008536	Ran GTPase binding	21873635.	IBA	Function
GO:0016032	viral process	-	TAS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046604	positive regulation of mitotic centrosome separation	21873635.	IBA	Process
GO:0046907	intracellular transport	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.