EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25774502	Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.	J Clin Invest	2015 Apr	van Roosmalen W	doi: 10.1172/JCI74440
24961466	Serine-arginine protein kinase 1 is associated with breast cancer progression and poor patient survival.	Med Oncol	2014 Aug	Li XH	doi: 10.1007/s12032-014-0083-8
26500332	Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.	J Clin Pathol	2016 Feb	Bullock N	doi: 10.1136/jclinpath-2015-203125
25140042	Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.	RNA	2014 Oct	Lin JC	doi: 10.1261/rna.045583.114

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	35869860	Missense_Mutation	NA	R345C	0.84
BLCA	chr6	35835438	Missense_Mutation	novel	L612V	0.23
BLCA	chr6	35838743	Intron	NA		0.2
BLCA	chr6	35888889	Silent	novel	F76F	0.4
BLCA	chr6	35835327	Missense_Mutation	rs202045785	R649W	0.2
BRCA	chr6	35890934	Missense_Mutation	novel	D52H	0.1
BRCA	chr6	35869060	Missense_Mutation	NA	A488T	0.47
BRCA	chr6	35842532	Splice_Region	NA		0.14
BRCA	chr6	35835230	3'UTR	novel		0.33
BRCA	chr6	35835188	3'UTR	novel		0.14
BRCA	chr6	35835057	3'UTR	novel		0.17
BRCA	chr6	35842585	Missense_Mutation	NA	G547V	0.41
BRCA	chr6	35888866	Missense_Mutation	rs371124622	R84Q	0.17
BRCA	chr6	35869874	Missense_Mutation	novel	Q340R	0.06
CESC	chr6	35874265	Missense_Mutation	novel	P185A	0.45
CESC	chr6	35838743	Intron	NA		0.4
CESC	chr6	35834915	3'UTR	novel		0.47
CESC	chr6	35834070	3'UTR	novel		0.59
CESC	chr6	35833521	3'UTR	novel		0.15
CHOL	chr6	35835178	3'UTR	novel		0.48
COAD	chr6	35869585	Silent	NA	S436S	0.46
COAD	chr6	35857328	Missense_Mutation	rs771188043	R518H	0.36
COAD	chr6	35886736	Missense_Mutation	NA	V156I	0.31
COAD	chr6	35870315	Missense_Mutation	novel	E319D	0.08
COAD	chr6	35888815	Missense_Mutation	novel	Q101P	0.22
COAD	chr6	35835485	Missense_Mutation	novel	D596G	0.37
COAD	chr6	35838338	Frame_Shift_Del	novel	*G595Vfs3**	0.79
COAD	chr6	35890899	Silent	NA	C63C	0.38
COAD	chr6	35920549	Intron	novel		0.29
COAD	chr6	35869062	Frame_Shift_Del	NA	*N487Mfs7**	0.08
COAD	chr6	35874244	Frame_Shift_Del	rs34144793	*I192Lfs32**	0.31
COAD	chr6	35872722	Nonsense_Mutation	NA	Q198*	0.41
COAD	chr6	35890959	Silent	NA	E43E	0.11
COAD	chr6	35886768	Missense_Mutation	novel	V145A	0.14
COAD	chr6	35874243	Frame_Shift_Ins	novel	*I192Nfs10**	0.27
COAD	chr6	35835339	Missense_Mutation	rs376455081	A645T	0.24
COAD	chr6	35869568	In_Frame_Ins	novel	I442delinsKNNHTF	0.04
COAD	chr6	35870346	Nonsense_Mutation	novel	*S309Ffs3**	0.04
COAD	chr6	35920609	Intron	novel		0.18
COAD	chr6	35835178	3'UTR	novel		0.66
COAD	chr6	35857314	Missense_Mutation	novel	L523V	0.49
ESCA	chr6	35870367	Frame_Shift_Ins	novel	*R302Kfs13**	0.21
ESCA	chr6	35869654	Frame_Shift_Del	novel	*S413Vfs4**	0.28
ESCA	chr6	35834274	3'UTR	novel		0.55
GBM	chr6	35888052	Missense_Mutation	NA	A121G	0.42
GBM	chr6	35870443	Missense_Mutation	novel	R277C	0.33
HNSC	chr6	35920470	Splice_Region	novel	R24R	0.39
HNSC	chr6	35869626	Missense_Mutation	novel	D423H	0.26
KIRC	chr6	35870348	Silent	NA	E308E	0.25
KIRP	chr6	35835347	Missense_Mutation	novel	A642V	0.92
KIRP	chr6	35835348	Missense_Mutation	novel	A642T	0.92
LGG	chr6	35842586	Missense_Mutation	novel	G547C	0.29
LIHC	chr6	35838373	Missense_Mutation	novel	A583S	0.39
LIHC	chr6	35921086	5'UTR	novel		0.13
LIHC	chr6	35921116	5'UTR	novel		0.38
LUAD	chr6	35872592	Missense_Mutation	novel	S241C	0.12
LUAD	chr6	35869557	Nonsense_Mutation	novel	Q446*	0.1
LUAD	chr6	35857344	Frame_Shift_Ins	novel	*Q513Sfs12**	0.17
LUAD	chr6	35870281	Missense_Mutation	novel	E331K	0.14
LUAD	chr6	35869530	Missense_Mutation	NA	C455G	0.08
LUAD	chr6	35842571	Missense_Mutation	NA	E552Q	0.29
LUAD	chr6	35874303	Missense_Mutation	NA	L172R	0.21
LUSC	chr6	35835291	3'UTR	novel		0.12
LUSC	chr6	35869076	Silent	novel	P482P	0.19
LUSC	chr6	35857356	In_Frame_Ins	novel	F508_T509insWF	0.22
LUSC	chr6	35857357	Frame_Shift_Ins	novel	*F508Lfs3**	0.22
LUSC	chr6	35872628	Missense_Mutation	NA	R229Q	0.5
LUSC	chr6	35869711	Missense_Mutation	NA	E394D	0.53
LUSC	chr6	35869652	Missense_Mutation	NA	C414Y	0.1
LUSC	chr6	35920476	Silent	rs374532523	A22A	0.09
LUSC	chr6	35870350	Missense_Mutation	novel	E308Q	0.11
LUSC	chr6	35869846	Frame_Shift_Ins	novel	*G350Wfs6**	0.33
LUSC	chr6	35869903	Splice_Site	rs779715550	X331_splice	0.7
LUSC	chr6	35835445	Frame_Shift_Del	NA	*F609Lfs4**	0.26
OV	chr6	35835265	3'UTR	novel		0.05
OV	chr6	35869491	Missense_Mutation	NA	D468N	0.33
PAAD	chr6	35842571	Missense_Mutation	novel	E552K	0.18
PAAD	chr6	35874245	Missense_Mutation	novel	K191N	0.2
READ	chr6	35869655	Missense_Mutation	NA	S413Y	0.38
SARC	chr6	35869501	Missense_Mutation	novel	N464K	0.06
SARC	chr6	35870317	Missense_Mutation	novel	E319K	0.19
SARC	chr6	35870318	Missense_Mutation	novel	K318N	0.2
SKCM	chr6	35838747	Intron	novel		0.43
SKCM	chr6	35870302	Missense_Mutation	NA	K324E	0.45
SKCM	chr6	35872684	Silent	novel	I210I	0.38
SKCM	chr6	35870324	Silent	rs771145508	P316P	0.42
SKCM	chr6	35842603	Missense_Mutation	rs768705670	A541V	0.33
SKCM	chr6	35869655	Missense_Mutation	NA	S413F	0.26
SKCM	chr6	35869077	Missense_Mutation	NA	P482L	0.21
SKCM	chr6	35920498	Missense_Mutation	NA	T15I	0.32
SKCM	chr6	35888866	Missense_Mutation	rs371124622	R84Q	0.54
SKCM	chr6	35835360	Missense_Mutation	NA	P638S	0.17
SKCM	chr6	35842565	Missense_Mutation	novel	H554Y	0.39
SKCM	chr6	35920522	Missense_Mutation	NA	A7V	0.04
SKCM	chr6	35888918	Missense_Mutation	NA	Y67H	0.31
SKCM	chr6	35857314	Silent	NA	L523L	0.2
SKCM	chr6	35869539	Nonsense_Mutation	NA	E452*	0.11
SKCM	chr6	35869087	Missense_Mutation	novel	L479F	0.22
STAD	chr6	35869882	Silent	novel	G337G	0.23
STAD	chr6	35838772	Intron	NA		0.11
STAD	chr6	35870342	Missense_Mutation	novel	E310D	0.37
STAD	chr6	35857274	Missense_Mutation	NA	S536N	0.13
STAD	chr6	35835445	Frame_Shift_Del	NA	*F609Lfs4**	0.24
STAD	chr6	35869500	Missense_Mutation	rs768150388	G465R	0.29
STAD	chr6	35886722	Splice_Site	NA	X160_splice	0.17
THYM	chr6	35834013	3'UTR	novel		0.44
UCEC	chr6	35833169	3'UTR	novel		0.13
UCEC	chr6	35833290	3'UTR	novel		0.27
UCEC	chr6	35835181	3'UTR	novel		0.24
UCEC	chr6	35872596	Nonsense_Mutation	rs764836971	R240*	0.27
UCEC	chr6	35886812	Splice_Site	NA	X131_splice	0.39
UCEC	chr6	35838760	Intron	novel		0.29
UCEC	chr6	35834190	3'UTR	novel		0.25
UCEC	chr6	35886807	Missense_Mutation	rs775640291	R132H	0.51
UCEC	chr6	35835484	In_Frame_Ins	novel	D596delinsESFT	0.06
UCEC	chr6	35835336	Missense_Mutation	rs537927603	E646K	0.18
UCEC	chr6	35869104	Missense_Mutation	novel	S473F	0.18
UCEC	chr6	35835178	3'UTR	novel		0.52
UCEC	chr6	35834351	3'UTR	novel		0.57
UCEC	chr6	35833306	3'UTR	novel		0.43
UCEC	chr6	35857271	Missense_Mutation	rs778938649	T537M	0.15
UCEC	chr6	35869807	Silent	novel	V362V	0.28
UCEC	chr6	35835098	3'UTR	novel		0.25
UCEC	chr6	35869678	Silent	rs773383685	S405S	0.35
UCEC	chr6	35869062	Frame_Shift_Del	NA	*N487Mfs7**	0.22
UCEC	chr6	35834162	3'UTR	novel		0.47
UCEC	chr6	35888831	Silent	novel	L96L	0.2
UCEC	chr6	35835178	3'UTR	novel		0.71
UCEC	chr6	35834189	3'UTR	novel		0.6
UCEC	chr6	35834886	3'UTR	novel		0.33
UCEC	chr6	35833160	3'UTR	novel		0.27
UCEC	chr6	35920488	Missense_Mutation	novel	K18N	0.18
UCEC	chr6	35833430	3'UTR	novel		0.5
UCEC	chr6	35857329	Missense_Mutation	novel	R518C	0.5
UCEC	chr6	35857309	Silent	NA	I524I	0.4
UCEC	chr6	35835339	Missense_Mutation	rs376455081	A645T	0.49
UCEC	chr6	35872568	Missense_Mutation	NA	S249Y	0.19
UCEC	chr6	35833869	3'UTR	novel		0.33
UCEC	chr6	35833473	3'UTR	novel		0.23
UCEC	chr6	35869573	Silent	novel	Q440Q	0.35
UCEC	chr6	35869593	In_Frame_Ins	novel	V433_G434insR	0.02
UCEC	chr6	35886801	Nonsense_Mutation	novel	S134*	0.05
UCEC	chr6	35833038	3'UTR	novel		0.46
UCEC	chr6	35838409	Nonsense_Mutation	novel	E571*	0.19
UCEC	chr6	35869655	Missense_Mutation	NA	S413Y	0.23
UCEC	chr6	35835178	3'UTR	novel		0.42
UCEC	chr6	35833109	3'UTR	novel		0.43
UCEC	chr6	35835120	3'UTR	novel		0.41
UCEC	chr6	35869842	Missense_Mutation	novel	A351T	0.48
UCEC	chr6	35888076	Missense_Mutation	novel	S113I	0.53
UCEC	chr6	35835178	3'UTR	novel		0.46
UCEC	chr6	35869090	Missense_Mutation	NA	F478V	0.33
UCEC	chr6	35872595	Missense_Mutation	novel	R240Q	0.26
UCEC	chr6	35834161	3'UTR	novel		0.39
UCEC	chr6	35870948	Nonsense_Mutation	novel	P255*	0.04
UCEC	chr6	35833778	3'UTR	novel		0.33
UCEC	chr6	35870367	Frame_Shift_Ins	novel	*R302Kfs13**	0.46
UCEC	chr6	35835469	Silent	rs748106757	T601T	0.33
UCEC	chr6	35870418	Missense_Mutation	rs370292368	R285Q	0.28
UCEC	chr6	35834189	3'UTR	novel		0.92
UCEC	chr6	35870465	Missense_Mutation	NA	K269N	0.12
UCEC	chr6	35838794	Intron	novel		0.26
UCEC	chr6	35872628	Missense_Mutation	NA	R229Q	0.19
UCEC	chr6	35834189	3'UTR	novel		0.47
UCEC	chr6	35835178	3'UTR	novel		0.48
UCEC	chr6	35835412	Silent	novel	Q620Q	0.49
UCEC	chr6	35857300	Silent	novel	G527G	0.29
UCEC	chr6	35872579	Silent	novel	P245P	0.48
UCEC	chr6	35890943	Missense_Mutation	novel	L49M	0.31
UCS	chr6	35838392	Silent	novel	V576V	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
SARC	0.00014	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
SKCM	0.013	Kaplan-Meier Survival Analysis
BRCA	0.037	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
COAD	0.037	Kaplan-Meier Survival Analysis
PAAD	0.00021	Kaplan-Meier Survival Analysis
BLCA	0.0087	Kaplan-Meier Survival Analysis
CESC	0.028	Kaplan-Meier Survival Analysis
READ	0.0018	Kaplan-Meier Survival Analysis
KICH	0.027	Kaplan-Meier Survival Analysis
UCEC	0.0032	Kaplan-Meier Survival Analysis
GBM	0.019	Kaplan-Meier Survival Analysis
LIHC	0.00054	Kaplan-Meier Survival Analysis
CHOL	0.042	Kaplan-Meier Survival Analysis
LUAD	0.0086	Kaplan-Meier Survival Analysis
OV	0.023	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000096063 (Gene tree)
Gene ID: 6732
Gene Symbol: SRPK1
Alias: SFRSK1
Full Name: SRSF protein kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 88,377 bases
Position: chr6:35,832,966-35,921,342
Accession: 11305
RBP type: non-canonical RBP
Summary: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25140042	Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.	RNA	2014 Oct	Lin JC	doi: 10.1261/rna.045583.114
18022399	RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins.	Biochim Biophys Acta	2008 Feb	Nikolakaki E	-
22172722	WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.	Cancer Cell	2011 Dec 13	Amin EM	doi: 10.1016/j.ccr.2011.10.016.
26013829	Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1.	J Biol Chem	2015 Jul 10	Jamros MA	doi: 10.1074/jbc.M115.656579
30566530	Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.	PLoS Pathog	2018 Dec 19	Heger-Stevic J	doi: 10.1371/journal.ppat.1007488
21630460	Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.	Proteomics	2011 Jul	Dolai S	doi: 10.1002/pmic.201000801

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000513367	SRPK1-213	634	-	-	- (aa)	-	-
ENST00000423325	SRPK1-205	4357	-	ENSP00000391069	639 (aa)	-	Q96SB4
ENST00000346162	SRPK1-201	4762	-	-	- (aa)	-	-
ENST00000508473	SRPK1-210	858	-	ENSP00000425172	76 (aa)	-	D6RDZ3
ENST00000373821	SRPK1-203	565	-	-	- (aa)	-	-
ENST00000502969	SRPK1-206	370	-	-	- (aa)	-	-
ENST00000507909	SRPK1-209	581	-	ENSP00000424323	118 (aa)	-	D6RB98
ENST00000507292	SRPK1-208	634	-	ENSP00000422886	42 (aa)	-	H0Y932
ENST00000373825	SRPK1-204	4592	-	ENSP00000362931	655 (aa)	-	Q96SB4
ENST00000510290	SRPK1-211	621	-	ENSP00000424170	146 (aa)	-	D6RBF8
ENST00000512445	SRPK1-212	559	-	ENSP00000424068	155 (aa)	-	D6RBM8
ENST00000361690	SRPK1-202	4286	-	ENSP00000354674	671 (aa)	-	H3BLV9
ENST00000505885	SRPK1-207	566	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000096063's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000096063	Obesity	6.1830000E-005	-
ENSG00000096063	Obesity	7.3100000E-005	-
ENSG00000096063	Obesity	5.2210000E-005	-
ENSG00000096063	Blood Pressure	7.7460000E-005	-
ENSG00000096063	Platelet Function Tests	1.7088800E-005	-
ENSG00000096063	Platelet Function Tests	7.4700000E-006	-
ENSG00000096063	Platelet Function Tests	1.3802800E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000096063's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000096063	SRPK1	100	91.603	ENSMUSG00000004865	Srpk1	100	98.400	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	21873635.	IBA	Process
GO:0000287	magnesium ion binding	11509566.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004672	protein kinase activity	8208298.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9237760.11509566.	IDA	Function
GO:0005515	protein binding	9237760.10196197.11509566.17360743.21130767.22365833.23602568.	IPI	Function
GO:0005524	ATP binding	11509566.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11509566.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11509566.	IDA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006468	protein phosphorylation	9237760.11509566.	IDA	Process
GO:0007059	chromosome segregation	15034300.	IDA	Process
GO:0008380	RNA splicing	8208298.	TAS	Process
GO:0010468	regulation of gene expression	21873635.	IBA	Process
GO:0016032	viral process	-	IEA	Process
GO:0016363	nuclear matrix	-	IEA	Component
GO:0035092	sperm chromatin condensation	21205200.	TAS	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	11509566.	IDA	Process
GO:0045070	positive regulation of viral genome replication	20498328.	IDA	Process
GO:0045071	negative regulation of viral genome replication	12417631.	IDA	Process
GO:0045087	innate immune response	12417631.	IC	Process
GO:0048024	regulation of mRNA splicing, via spliceosome	21205200.	TAS	Process
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process
GO:0050684	regulation of mRNA processing	8208298.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.