EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25774502Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.J Clin Invest2015 Aprvan Roosmalen Wdoi: 10.1172/JCI74440
24961466Serine-arginine protein kinase 1 is associated with breast cancer progression and poor patient survival.Med Oncol2014 AugLi XHdoi: 10.1007/s12032-014-0083-8
26500332Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.J Clin Pathol2016 FebBullock Ndoi: 10.1136/jclinpath-2015-203125
25140042Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.RNA2014 OctLin JCdoi: 10.1261/rna.045583.114

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr635869860Missense_MutationNAR345C0.84
BLCAchr635835438Missense_MutationnovelL612V0.23
BLCAchr635838743IntronNA0.2
BLCAchr635888889SilentnovelF76F0.4
BLCAchr635835327Missense_Mutationrs202045785R649W0.2
BRCAchr635890934Missense_MutationnovelD52H0.1
BRCAchr635869060Missense_MutationNAA488T0.47
BRCAchr635842532Splice_RegionNA0.14
BRCAchr6358352303'UTRnovel0.33
BRCAchr6358351883'UTRnovel0.14
BRCAchr6358350573'UTRnovel0.17
BRCAchr635842585Missense_MutationNAG547V0.41
BRCAchr635888866Missense_Mutationrs371124622R84Q0.17
BRCAchr635869874Missense_MutationnovelQ340R0.06
CESCchr635874265Missense_MutationnovelP185A0.45
CESCchr635838743IntronNA0.4
CESCchr6358349153'UTRnovel0.47
CESCchr6358340703'UTRnovel0.59
CESCchr6358335213'UTRnovel0.15
CHOLchr6358351783'UTRnovel0.48
COADchr635869585SilentNAS436S0.46
COADchr635857328Missense_Mutationrs771188043R518H0.36
COADchr635886736Missense_MutationNAV156I0.31
COADchr635870315Missense_MutationnovelE319D0.08
COADchr635888815Missense_MutationnovelQ101P0.22
COADchr635835485Missense_MutationnovelD596G0.37
COADchr635838338Frame_Shift_DelnovelG595Vfs*30.79
COADchr635890899SilentNAC63C0.38
COADchr635920549Intronnovel0.29
COADchr635869062Frame_Shift_DelNAN487Mfs*70.08
COADchr635874244Frame_Shift_Delrs34144793I192Lfs*320.31
COADchr635872722Nonsense_MutationNAQ198*0.41
COADchr635890959SilentNAE43E0.11
COADchr635886768Missense_MutationnovelV145A0.14
COADchr635874243Frame_Shift_InsnovelI192Nfs*100.27
COADchr635835339Missense_Mutationrs376455081A645T0.24
COADchr635869568In_Frame_InsnovelI442delinsKNNHTF0.04
COADchr635870346Nonsense_MutationnovelS309Ffs*30.04
COADchr635920609Intronnovel0.18
COADchr6358351783'UTRnovel0.66
COADchr635857314Missense_MutationnovelL523V0.49
ESCAchr635870367Frame_Shift_InsnovelR302Kfs*130.21
ESCAchr635869654Frame_Shift_DelnovelS413Vfs*40.28
ESCAchr6358342743'UTRnovel0.55
GBMchr635888052Missense_MutationNAA121G0.42
GBMchr635870443Missense_MutationnovelR277C0.33
HNSCchr635920470Splice_RegionnovelR24R0.39
HNSCchr635869626Missense_MutationnovelD423H0.26
KIRCchr635870348SilentNAE308E0.25
KIRPchr635835347Missense_MutationnovelA642V0.92
KIRPchr635835348Missense_MutationnovelA642T0.92
LGGchr635842586Missense_MutationnovelG547C0.29
LIHCchr635838373Missense_MutationnovelA583S0.39
LIHCchr6359210865'UTRnovel0.13
LIHCchr6359211165'UTRnovel0.38
LUADchr635872592Missense_MutationnovelS241C0.12
LUADchr635869557Nonsense_MutationnovelQ446*0.1
LUADchr635857344Frame_Shift_InsnovelQ513Sfs*120.17
LUADchr635870281Missense_MutationnovelE331K0.14
LUADchr635869530Missense_MutationNAC455G0.08
LUADchr635842571Missense_MutationNAE552Q0.29
LUADchr635874303Missense_MutationNAL172R0.21
LUSCchr6358352913'UTRnovel0.12
LUSCchr635869076SilentnovelP482P0.19
LUSCchr635857356In_Frame_InsnovelF508_T509insWF0.22
LUSCchr635857357Frame_Shift_InsnovelF508Lfs*30.22
LUSCchr635872628Missense_MutationNAR229Q0.5
LUSCchr635869711Missense_MutationNAE394D0.53
LUSCchr635869652Missense_MutationNAC414Y0.1
LUSCchr635920476Silentrs374532523A22A0.09
LUSCchr635870350Missense_MutationnovelE308Q0.11
LUSCchr635869846Frame_Shift_InsnovelG350Wfs*60.33
LUSCchr635869903Splice_Siters779715550X331_splice0.7
LUSCchr635835445Frame_Shift_DelNAF609Lfs*40.26
OVchr6358352653'UTRnovel0.05
OVchr635869491Missense_MutationNAD468N0.33
PAADchr635842571Missense_MutationnovelE552K0.18
PAADchr635874245Missense_MutationnovelK191N0.2
READchr635869655Missense_MutationNAS413Y0.38
SARCchr635869501Missense_MutationnovelN464K0.06
SARCchr635870317Missense_MutationnovelE319K0.19
SARCchr635870318Missense_MutationnovelK318N0.2
SKCMchr635838747Intronnovel0.43
SKCMchr635870302Missense_MutationNAK324E0.45
SKCMchr635872684SilentnovelI210I0.38
SKCMchr635870324Silentrs771145508P316P0.42
SKCMchr635842603Missense_Mutationrs768705670A541V0.33
SKCMchr635869655Missense_MutationNAS413F0.26
SKCMchr635869077Missense_MutationNAP482L0.21
SKCMchr635920498Missense_MutationNAT15I0.32
SKCMchr635888866Missense_Mutationrs371124622R84Q0.54
SKCMchr635835360Missense_MutationNAP638S0.17
SKCMchr635842565Missense_MutationnovelH554Y0.39
SKCMchr635920522Missense_MutationNAA7V0.04
SKCMchr635888918Missense_MutationNAY67H0.31
SKCMchr635857314SilentNAL523L0.2
SKCMchr635869539Nonsense_MutationNAE452*0.11
SKCMchr635869087Missense_MutationnovelL479F0.22
STADchr635869882SilentnovelG337G0.23
STADchr635838772IntronNA0.11
STADchr635870342Missense_MutationnovelE310D0.37
STADchr635857274Missense_MutationNAS536N0.13
STADchr635835445Frame_Shift_DelNAF609Lfs*40.24
STADchr635869500Missense_Mutationrs768150388G465R0.29
STADchr635886722Splice_SiteNAX160_splice0.17
THYMchr6358340133'UTRnovel0.44
UCECchr6358331693'UTRnovel0.13
UCECchr6358332903'UTRnovel0.27
UCECchr6358351813'UTRnovel0.24
UCECchr635872596Nonsense_Mutationrs764836971R240*0.27
UCECchr635886812Splice_SiteNAX131_splice0.39
UCECchr635838760Intronnovel0.29
UCECchr6358341903'UTRnovel0.25
UCECchr635886807Missense_Mutationrs775640291R132H0.51
UCECchr635835484In_Frame_InsnovelD596delinsESFT0.06
UCECchr635835336Missense_Mutationrs537927603E646K0.18
UCECchr635869104Missense_MutationnovelS473F0.18
UCECchr6358351783'UTRnovel0.52
UCECchr6358343513'UTRnovel0.57
UCECchr6358333063'UTRnovel0.43
UCECchr635857271Missense_Mutationrs778938649T537M0.15
UCECchr635869807SilentnovelV362V0.28
UCECchr6358350983'UTRnovel0.25
UCECchr635869678Silentrs773383685S405S0.35
UCECchr635869062Frame_Shift_DelNAN487Mfs*70.22
UCECchr6358341623'UTRnovel0.47
UCECchr635888831SilentnovelL96L0.2
UCECchr6358351783'UTRnovel0.71
UCECchr6358341893'UTRnovel0.6
UCECchr6358348863'UTRnovel0.33
UCECchr6358331603'UTRnovel0.27
UCECchr635920488Missense_MutationnovelK18N0.18
UCECchr6358334303'UTRnovel0.5
UCECchr635857329Missense_MutationnovelR518C0.5
UCECchr635857309SilentNAI524I0.4
UCECchr635835339Missense_Mutationrs376455081A645T0.49
UCECchr635872568Missense_MutationNAS249Y0.19
UCECchr6358338693'UTRnovel0.33
UCECchr6358334733'UTRnovel0.23
UCECchr635869573SilentnovelQ440Q0.35
UCECchr635869593In_Frame_InsnovelV433_G434insR0.02
UCECchr635886801Nonsense_MutationnovelS134*0.05
UCECchr6358330383'UTRnovel0.46
UCECchr635838409Nonsense_MutationnovelE571*0.19
UCECchr635869655Missense_MutationNAS413Y0.23
UCECchr6358351783'UTRnovel0.42
UCECchr6358331093'UTRnovel0.43
UCECchr6358351203'UTRnovel0.41
UCECchr635869842Missense_MutationnovelA351T0.48
UCECchr635888076Missense_MutationnovelS113I0.53
UCECchr6358351783'UTRnovel0.46
UCECchr635869090Missense_MutationNAF478V0.33
UCECchr635872595Missense_MutationnovelR240Q0.26
UCECchr6358341613'UTRnovel0.39
UCECchr635870948Nonsense_MutationnovelP255*0.04
UCECchr6358337783'UTRnovel0.33
UCECchr635870367Frame_Shift_InsnovelR302Kfs*130.46
UCECchr635835469Silentrs748106757T601T0.33
UCECchr635870418Missense_Mutationrs370292368R285Q0.28
UCECchr6358341893'UTRnovel0.92
UCECchr635870465Missense_MutationNAK269N0.12
UCECchr635838794Intronnovel0.26
UCECchr635872628Missense_MutationNAR229Q0.19
UCECchr6358341893'UTRnovel0.47
UCECchr6358351783'UTRnovel0.48
UCECchr635835412SilentnovelQ620Q0.49
UCECchr635857300SilentnovelG527G0.29
UCECchr635872579SilentnovelP245P0.48
UCECchr635890943Missense_MutationnovelL49M0.31
UCSchr635838392SilentnovelV576V0.21

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

SARC0.00014

Kaplan-Meier Survival Analysis

MESO0.00015

Kaplan-Meier Survival Analysis

ACC0.013

Kaplan-Meier Survival Analysis

SKCM0.013

Kaplan-Meier Survival Analysis

BRCA0.037

Kaplan-Meier Survival Analysis

KIRP0.01

Kaplan-Meier Survival Analysis

COAD0.037

Kaplan-Meier Survival Analysis

PAAD0.00021

Kaplan-Meier Survival Analysis

BLCA0.0087

Kaplan-Meier Survival Analysis

CESC0.028

Kaplan-Meier Survival Analysis

READ0.0018

Kaplan-Meier Survival Analysis

KICH0.027

Kaplan-Meier Survival Analysis

UCEC0.0032

Kaplan-Meier Survival Analysis

GBM0.019

Kaplan-Meier Survival Analysis

LIHC0.00054

Kaplan-Meier Survival Analysis

CHOL0.042

Kaplan-Meier Survival Analysis

LUAD0.0086

Kaplan-Meier Survival Analysis

OV0.023

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000096063 (Gene tree)
Gene ID
6732
Gene Symbol
SRPK1
Alias
SFRSK1
Full Name
SRSF protein kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
88,377 bases
Position
chr6:35,832,966-35,921,342
Accession
11305
RBP type
non-canonical RBP
Summary
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25140042Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.RNA2014 OctLin JCdoi: 10.1261/rna.045583.114
18022399RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins.Biochim Biophys Acta2008 FebNikolakaki E-
22172722WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.Cancer Cell2011 Dec 13Amin EMdoi: 10.1016/j.ccr.2011.10.016.
26013829Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1.J Biol Chem2015 Jul 10Jamros MAdoi: 10.1074/jbc.M115.656579
30566530Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.PLoS Pathog2018 Dec 19Heger-Stevic Jdoi: 10.1371/journal.ppat.1007488
21630460Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.Proteomics2011 JulDolai Sdoi: 10.1002/pmic.201000801
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000513367SRPK1-213634--- (aa)--
ENST00000423325SRPK1-2054357-ENSP00000391069639 (aa)-Q96SB4
ENST00000346162SRPK1-2014762--- (aa)--
ENST00000508473SRPK1-210858-ENSP0000042517276 (aa)-D6RDZ3
ENST00000373821SRPK1-203565--- (aa)--
ENST00000502969SRPK1-206370--- (aa)--
ENST00000507909SRPK1-209581-ENSP00000424323118 (aa)-D6RB98
ENST00000507292SRPK1-208634-ENSP0000042288642 (aa)-H0Y932
ENST00000373825SRPK1-2044592-ENSP00000362931655 (aa)-Q96SB4
ENST00000510290SRPK1-211621-ENSP00000424170146 (aa)-D6RBF8
ENST00000512445SRPK1-212559-ENSP00000424068155 (aa)-D6RBM8
ENST00000361690SRPK1-2024286-ENSP00000354674671 (aa)-H3BLV9
ENST00000505885SRPK1-207566--- (aa)--
Gene Model
Click here to download ENSG00000096063's gene model file
Pathways
Pathway IDPathway NameSource
hsa05168Herpes simplex virus 1 infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000096063Obesity6.1830000E-005-
ENSG00000096063Obesity7.3100000E-005-
ENSG00000096063Obesity5.2210000E-005-
ENSG00000096063Blood Pressure7.7460000E-005-
ENSG00000096063Platelet Function Tests1.7088800E-005-
ENSG00000096063Platelet Function Tests7.4700000E-006-
ENSG00000096063Platelet Function Tests1.3802800E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000096063's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000096063SRPK110091.603ENSMUSG00000004865Srpk110098.400Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000245spliceosomal complex assembly21873635.IBAProcess
GO:0000287magnesium ion binding11509566.IDAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0004672protein kinase activity8208298.TASFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity9237760.11509566.IDAFunction
GO:0005515protein binding9237760.10196197.11509566.17360743.21130767.22365833.23602568.IPIFunction
GO:0005524ATP binding11509566.IDAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11509566.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm11509566.IDAComponent
GO:0005783endoplasmic reticulum-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005886plasma membrane-IDAComponent
GO:0006468protein phosphorylation9237760.11509566.IDAProcess
GO:0007059chromosome segregation15034300.IDAProcess
GO:0008380RNA splicing8208298.TASProcess
GO:0010468regulation of gene expression21873635.IBAProcess
GO:0016032viral process-IEAProcess
GO:0016363nuclear matrix-IEAComponent
GO:0035092sperm chromatin condensation21205200.TASProcess
GO:0035556intracellular signal transduction21873635.IBAProcess
GO:0035556intracellular signal transduction11509566.IDAProcess
GO:0045070positive regulation of viral genome replication20498328.IDAProcess
GO:0045071negative regulation of viral genome replication12417631.IDAProcess
GO:0045087innate immune response12417631.ICProcess
GO:0048024regulation of mRNA splicing, via spliceosome21205200.TASProcess
GO:0050684regulation of mRNA processing21873635.IBAProcess
GO:0050684regulation of mRNA processing8208298.IDAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us