EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24518087Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer.J Thorac Oncol2014 MarOcak Sdoi: 10.1097/JTO.0000000000000090.
23381229Collapsin response mediator protein 2 is involved in regulating breast cancer progression.Breast Cancer2014 NovShimada Kdoi: 10.1007/s12282-013-0447-5
23023514Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC.Int J Cancer2013 May 1Oliemuller Edoi: 10.1002/ijc.27881
18203259Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes.Proteomics2008 JanWu CCdoi: 10.1002/pmic.200700819.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr826647627Splice_Regionnovel0.38
BLCAchr826647708Missense_MutationnovelR397W0.23
BLCAchr826627293Nonsense_MutationnovelE207*0.05
BLCAchr826643486Missense_MutationNAG287S0.32
BLCAchr826652374Missense_Mutationrs773717246R467C0.3
BRCAchr8266581293'UTRnovel0.25
BRCAchr8266580053'UTRnovel0.17
BRCAchr826647704Frame_Shift_DelnovelR397Gfs*950.13
BRCAchr826583868Missense_MutationNAI66M0.16
BRCAchr826627251Missense_Mutationrs143980725A193T0.15
BRCAchr8265781075'UTRnovel0.5
BRCAchr826643485Silentrs138088405D286D0.1
BRCAchr826626674Missense_MutationNAC179Y0.25
CESCchr826647704SilentnovelY395Y0.15
CESCchr826652293Missense_Mutationrs779134278R440C0.43
CESCchr826583893Missense_Mutationrs774132967R75C0.53
CESCchr826647750Missense_MutationnovelI411L0.33
CESCchr8265781255'UTRnovel0.47
CESCchr826634893SilentnovelR268R0.29
CESCchr826652282Missense_MutationnovelG436D0.57
CESCchr8266572643'UTRrs5358051740.11
CESCchr8266573063'UTRnovel0.25
COADchr8265781765'UTRnovel0.27
COADchr826624244Missense_MutationNAV139M0.29
COADchr8265782545'UTRnovel0.34
COADchr826634882Missense_Mutationrs751569597A265T0.29
COADchr826655668Frame_Shift_DelNAG563Vfs*1210.62
COADchr826634891Missense_MutationnovelR268W0.33
COADchr826624267Silentrs760000083K146K0.1
COADchr826627280Silentrs773335767G202G0.36
COADchr826643486Missense_MutationNAG287S0.31
COADchr826583872Missense_MutationnovelG68R0.4
COADchr826653296Missense_Mutationrs374825617T509M0.28
COADchr826653307Missense_MutationNAV513I0.17
COADchr826581976Missense_Mutationrs765937076R16H0.37
COADchr826634892Missense_MutationNAR268Q0.23
GBMchr826643982Missense_MutationnovelC334S0.06
GBMchr826653249SilentNAG493G0.23
GBMchr826583905Missense_MutationnovelP79S0.49
GBMchr826652413Frame_Shift_InsnovelK480Tfs*110.06
GBMchr826634832Missense_MutationnovelC248Y0.1
GBMchr826653240SilentnovelE490E0.47
GBMchr826624300Frame_Shift_DelnovelD158Ifs*40.2
GBMchr826643526Missense_MutationnovelA300D0.06
HNSCchr826624239Missense_MutationnovelL137Q0.23
HNSCchr826634788Silentrs529587582A233A0.33
HNSCchr826578412Intronnovel0.12
HNSCchr826634801Missense_MutationNAR238C0.04
HNSCchr826626648Missense_MutationnovelF170L0.22
HNSCchr826644047Missense_MutationnovelN356Y0.42
KICHchr826655673Silentrs747715290P562P0.15
KIRPchr826647680Missense_MutationnovelN387K0.61
LIHCchr826627920Missense_MutationNAV224L0.21
LUADchr826634791Missense_MutationNAE234D0.15
LUADchr826583858Missense_MutationnovelR63L0.1
LUADchr826644073SilentNAV364V0.12
LUADchr826655701Missense_MutationNAG572C0.12
LUADchr826583942Missense_Mutationrs113269672Q91R0.19
LUADchr826627280SilentnovelG202G0.22
LUSCchr826634884SilentnovelA265A0.67
LUSCchr826643513Missense_MutationnovelA296S0.47
LUSCchr826643458Missense_MutationnovelE277D0.53
LUSCchr826653242Missense_MutationNAL491Q0.09
LUSCchr826655701Missense_MutationnovelG572R0.2
MESOchr826653232Missense_MutationnovelL488V0.29
OVchr826583858Missense_MutationnovelR63L0.07
OVchr826627215Missense_MutationNAI181V0.37
PAADchr826634816Missense_MutationNAA243T0.18
PRADchr826627221Missense_MutationNAE183K0.18
PRADchr826624307Missense_MutationnovelG160R0.34
READchr826583888In_Frame_DelnovelT74_D80del0.11
READchr826647768Missense_Mutationrs771160273V417I0.4
READchr8265782545'UTRnovel0.1
READchr826647735Missense_MutationNAD406N0.44
READchr8266557713'UTRnovel0.4
SKCMchr826653379Missense_MutationnovelS537P0.25
SKCMchr826655668Missense_MutationnovelP561S0.63
SKCMchr826583844Silentrs374040535I58I0.32
SKCMchr826578272SilentNAK6K0.19
SKCMchr826583869Missense_MutationnovelP67S0.24
SKCMchr8265782425'UTRnovel0.24
SKCMchr826643527Silentrs764265785A300A0.32
SKCMchr826647749SilentNAV410V0.1
SKCMchr826655661Silentrs780843208I558I0.28
SKCMchr826647749SilentNAV410V0.37
SKCMchr826626655Missense_Mutationrs781052884R173C0.14
SKCMchr826643584SilentNAS319S0.17
SKCMchr826647734Silentrs757945823S405S0.16
SKCMchr826624209Missense_MutationNAA127V0.38
SKCMchr826583893Missense_Mutationrs774132967R75C0.41
SKCMchr826653313Missense_MutationNAP515S0.17
STADchr826643528Missense_MutationnovelF301V0.14
STADchr8266557373'UTRnovel0.29
STADchr8265782545'UTRnovel0.23
STADchr826647717Missense_Mutationrs765277758R400C0.1
STADchr826624243SilentNAH138H0.22
STADchr826647731SilentNAG404G0.07
STADchr8265782375'UTRnovel0.26
STADchr826583894Missense_Mutationrs759388658R75H0.45
STADchr826634859Missense_MutationnovelS257N0.12
STADchr826624151Missense_Mutationrs752044385V108I0.44
UCECchr826652361Silentrs139997920T462T0.47
UCECchr826627269Missense_Mutationrs765160936A199T0.33
UCECchr826624276Missense_MutationNAQ149H0.28
UCECchr826624203Missense_MutationnovelE125G0.06
UCECchr8266565203'UTRnovel0.27
UCECchr826643952Missense_MutationnovelG324V0.2
UCECchr826634801Missense_MutationNAR238C0.45
UCECchr826583845Missense_MutationNAE59K0.41
UCECchr8265781755'UTRnovel0.52
UCECchr8266572643'UTRrs5358051740.35
UCECchr8265781575'UTRnovel0.35
UCECchr8266571433'UTRnovel0.4
UCECchr826583812Missense_MutationnovelN48H0.43
UCECchr826644062Missense_MutationnovelR361W0.45
UCECchr826643954Missense_MutationnovelD325Y0.3
UCECchr826581997Missense_MutationnovelK23T0.28
UCECchr826643570Missense_MutationnovelD315Y0.07
UCECchr8266567283'UTRnovel0.24
UCECchr826627281Missense_Mutationrs762997682D203N0.42
UCECchr826627910Silentrs145417759P220P0.09
UCECchr826624156SilentnovelV109V0.07
UCECchr826581976Missense_Mutationrs765937076R16H0.48
UCECchr8266576553'UTRnovel0.14
UCECchr826583954Missense_MutationNAA95V0.25
UCECchr826653236Missense_MutationNAA489V0.51
UCECchr826643949Splice_SitenovelX323_splice0.05
UCECchr8266576553'UTRnovel0.27
UCECchr8265781765'UTRnovel0.49
UCECchr8266573723'UTRnovel0.34
UCECchr826647706Missense_MutationnovelP396H0.21
UCECchr8266578263'UTRnovel0.36
UCECchr826624180Silentrs779830687L117L0.22
UCECchr8265780865'UTRnovel0.36
UCECchr826582019Silentrs199994960S30S0.22
UCECchr8265781765'UTRnovel0.4
UCECchr826644063Missense_MutationNAR361Q0.38
UCECchr8266578853'UTRnovel0.32
UCECchr826581976Missense_Mutationrs765937076R16H0.47
UCECchr826626619Missense_MutationnovelV161I0.38
UCECchr8266575763'UTRnovel0.45
UCECchr826634802Missense_MutationnovelR238H0.77
UCECchr8266573063'UTRnovel0.48
UCECchr8265781765'UTRnovel0.43
UCECchr826634888Missense_MutationNAA267T0.11
UCECchr826643439Missense_MutationnovelG271E0.59
UCECchr826653333Silentrs768396730T521T0.61
UCECchr8266581633'UTRnovel0.67
UCECchr826644018Missense_MutationnovelD346G0.13
UCECchr8266557843'UTRnovel0.64
UCECchr8266580443'UTRrs352586910.67
UCECchr826655622Missense_MutationnovelQ545H0.22
UCECchr8266581433'UTRnovel0.29
UCECchr826583812Missense_MutationnovelN48H0.3
UCECchr826647767Silentrs151050891S416S0.43
UCECchr826655645Missense_MutationnovelR553H0.41
UCECchr8266563463'UTRnovel0.29
UCECchr826652295Silentrs144002094R440R0.29
UCECchr826647699Missense_MutationnovelL394I0.35
UCECchr826652432Missense_Mutationrs764560894S486N0.32
UCECchr826653332Missense_MutationnovelT521M0.26
UCECchr8266575313'UTRnovel0.35
UCECchr8266581373'UTRnovel0.3
UCECchr8266563063'UTRnovel0.07
UCECchr826583845Missense_MutationNAE59K0.58
UCECchr826634860SilentNAS257S0.39
UCECchr8266562843'UTRnovel0.15
UCECchr826647801Splice_SitenovelX427_splice0.61
UCECchr826627280Silentrs773335767G202G0.18
UCECchr8266564713'UTRnovel0.38
UCECchr8266579193'UTRnovel0.5
UCECchr8266572443'UTRnovel0.21
UCECchr8266557843'UTRnovel0.41
UCECchr826643457Missense_MutationNAE277G0.47
UCECchr8265781755'UTRnovel0.42
UCECchr826627921Missense_MutationnovelV224A0.33
UCECchr8266558293'UTRnovel0.17
UCECchr8266565393'UTRnovel0.35
UCECchr8266575303'UTRnovel0.36
UCECchr8266580443'UTRrs352586910.44
UCECchr826643486Missense_MutationNAG287S0.32
UCECchr826644036Missense_MutationNAP352L0.34
UCECchr8265781755'UTRnovel0.35
UCECchr8266565363'UTRnovel0.35
UCECchr8265781755'UTRnovel0.24
UCECchr826644091Splice_RegionnovelV370V0.05
UCSchr8265781755'UTRnovel0.2
UCSchr826624150Silentrs113199330H107H0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.55154.5185e-08
DLBCDEL0.20830.15679
ESCADEL0.41850.060925
KIRCAMP0.02840.12739
PAADDEL0.22830.050455
READDEL0.57580.20625
THCADEL0.0080.21991
UCECDEL0.20411.6228e-10
UCSDEL0.51790.0031922

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.03

Kaplan-Meier Survival Analysis

ACC0.0013

Kaplan-Meier Survival Analysis

HNSC0.032

Kaplan-Meier Survival Analysis

SKCM0.035

Kaplan-Meier Survival Analysis

LUSC0.007

Kaplan-Meier Survival Analysis

KIRP0.037

Kaplan-Meier Survival Analysis

PAAD0.0056

Kaplan-Meier Survival Analysis

BLCA0.00045

Kaplan-Meier Survival Analysis

CESC0.017

Kaplan-Meier Survival Analysis

LAML0.00074

Kaplan-Meier Survival Analysis

UCEC0.016

Kaplan-Meier Survival Analysis

LGG0.00046

Kaplan-Meier Survival Analysis

CHOL0.043

Kaplan-Meier Survival Analysis

THCA0.046

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

UVM0.011

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000092964 (Gene tree)
Gene ID
1808
Gene Symbol
DPYSL2
Alias
DRP-2|DHPRP2|CRMP2|DRP2
Full Name
dihydropyrimidinase like 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
144,157 bases
Position
chr8:26,514,022-26,658,178
Accession
3014
RBP type
non-canonical RBP
Summary
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000474808DPYSL2-202566--- (aa)--
ENST00000523093DPYSL2-207728--- (aa)--
ENST00000311151DPYSL2-2014603-ENSP00000309539572 (aa)-Q16555
ENST00000523690DPYSL2-208544--- (aa)--
ENST00000521983DPYSL2-205591--- (aa)--
ENST00000521913DPYSL2-2044805-ENSP00000427985677 (aa)-A0A1C7CYX9
ENST00000493789DPYSL2-203562-ENSP00000427954170 (aa)-E5RFU4
ENST00000523027DPYSL2-2062130-ENSP00000431117536 (aa)-Q16555
Gene Model
Click here to download ENSG00000092964's gene model file
Pathways
Pathway IDPathway NameSource
hsa04360Axon guidanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000092964Cholesterol, LDL8.5860000E-005-
ENSG00000092964Erythrocyte Indices7.2870000E-005-
ENSG00000092964Erythrocyte Count3.0240000E-005-
ENSG00000092964Leukoaraiosis3.6818886E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000092964rs562044044826604499GPlasma trimethyllysine levels29563342[0.19-0.41] unit increase0.301EFO_0009134
ENSG00000092964rs10107066826542619?Cardiovascular disease30595370EFO_0000319
ENSG00000092964rs17321041826587678CDiastolic blood pressure30224653[0.16-0.3] mmHg decrease0.2313EFO_0006336
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092964's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000092964DPYSL29976.708ENSG00000113657DPYSL310089.130Homo_sapiens
ENSG00000092964DPYSL210098.776ENSMUSG00000022048Dpysl210098.776Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004157dihydropyrimidinase activity8973361.TASFunction
GO:0005515protein binding16260607.19235893.21900206.25416956.IPIFunction
GO:0005829cytosol20801876.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule20801876.IDAComponent
GO:0005886plasma membrane-IDAComponent
GO:0006139nucleobase-containing compound metabolic process8973361.TASProcess
GO:0006897endocytosis20801876.IMPProcess
GO:0007010cytoskeleton organization-ISSProcess
GO:0007165signal transduction8973361.TASProcess
GO:0007399nervous system development8973361.TASProcess
GO:0007411axon guidance-IEAProcess
GO:0007420brain development-IEAProcess
GO:0008017microtubule binding-IEAFunction
GO:0016020membrane20801876.IDAComponent
GO:0030516regulation of axon extension-IEAProcess
GO:0042802identical protein binding21516116.25416956.IPIFunction
GO:0070062extracellular exosome20458337.HDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us