EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21465252	Ezrin expression as a prognostic marker in colorectal adenocarcinoma.	Pathol Oncol Res	2011 Dec	Patara M	doi: 10.1007/s12253-011-9389-4
22415480	Atypical ezrin localization as a marker of locally advanced breast cancer.	Breast Cancer Res Treat	2012 Aug	Arslan AA	doi: 10.1007/s10549-012-2017-5
25337200	miR-183 inhibits invasion of gastric cancer by targeting Ezrin.	Int J Clin Exp Pathol	2014 Aug 15	Cao LL	-
21352885	ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.	Biochimie	2011 May	Ou-Yang M	doi: 10.1016/j.biochi.2011.01.017
21868260	Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression.	Urol Oncol	2013 Aug	Athanasopoulou A	doi: 10.1016/j.urolonc.2011.07.003
17370040	Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases.	Clin Exp Metastasis	2007	Deng X	-
18725408	Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration.	J Biol Chem	2008 Oct 24	Austermann J	doi: 10.1074/jbc.M806145200
16633060	Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma.	Int J Gynecol Pathol	2006 Apr	Kbel M	-
17370041	Expression of the cytoskeleton linker protein ezrin in human cancers.	Clin Exp Metastasis	2007	Bruce B	-
19366061	Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw.	Tumori	2009 Jan-Feb	Park HR	-
21849257	Immunohistochemical expression of ezrin in cutaneous basal and squamous cell carcinomas.	Ann Diagn Pathol	2011 Dec	Abdou AG	doi: 10.1016/j.anndiagpath.2011.05.005
19786985	Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death.	Cell Res	2009 Dec	Wang S	doi: 10.1038/cr.2009.114
20128822	Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.	Cancer Sci	2010 Mar	Ling ZQ	doi: 10.1111/j.1349-7006.2009.01470.x
23894313	Prognostic value of Ezrin in solid tumors: a meta-analysis of the literature.	PLoS One	2013 Jul 19	Han K	doi: 10.1371/journal.pone.0068527
22629406	Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity.	PLoS One	2012	Zaarour RF	doi: 10.1371/journal.pone.0037490
23708420	Association between ezrin protein expression and the prognosis of colorectal adenocarcinoma.	Mol Med Rep	2013 Jul	Lin LJ	doi: 10.3892/mmr.2013.1490
21971708	Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors.	Mol Med Rep	2012 Jan	Weng WH	doi: 10.3892/mmr.2011.609
23422152	Ezrin gene expression and protein production in the CD44(+) subpopulation of SCC-9 cells in a malignant oral cancer cell line in vitro.	J Oral Maxillofac Surg	2013 Mar	Wu G	doi: 10.1016/j.joms.2012.11.011.
16554733	Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas.	Mod Pathol	2006 Apr	Kbel M	-
27622508	Ezrin Is Associated with Disease Progression in Ovarian Carcinoma.	PLoS One	2016 Sep 13	Horwitz V	doi: 10.1371/journal.pone.0162502
28603065	A decision tree-based combination of ezrin-interacting proteins to estimate the prognostic risk of patients with esophageal squamous cell carcinoma.	Hum Pathol	2017 Aug	He JZ	doi: 10.1016/j.humpath.2017.06.003
28624994	Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.	Clin Exp Metastasis	2017 Jun	Bartova M	doi: 10.1007/s10585-017-9853-y
27793041	CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.	Oncotarget	2016 Nov 29	Riecken LB	doi: 10.18632/oncotarget.12919.
30226564	Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin.	Int J Mol Med	2018 Nov	Yan H	doi: 10.3892/ijmm.2018.3853
18701134	Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer.	Hum Pathol	2008 Dec	Elzagheid A	doi: 10.1016/j.humpath.2008.04.020
19399936	High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy.	World J Gastroenterol	2009 Apr 28	Wang HJ	-
22967445	[Expression of ezrin in human non-small cell lung cancer and its relationship with metastasis and prognosis].	Zhonghua Zhong Liu Za Zhi	2012 Jun	Chen QY	doi: 10
25278252	Incident urothelial cancer in the Malm Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.	Diagn Pathol	2014 Oct 3	Wennersten C	doi: 10.1186/s13000-014-0189-5.
20872967	Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.	World J Gastroenterol	2010 Oct 7	He ZY	-
19550117	Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.	Ai Zheng	2009 Feb	Ma L	-
21176563	[Potential role of ezrin and its related microRNA in ovarian cancer invasion and metastasis].	Zhonghua Fu Chan Ke Za Zhi	2010 Oct	Li J	-
23900701	Clinical implications of Ezrin and CD44 coexpression in breast cancer.	Oncol Rep	2013 Oct	Ma L	doi: 10.3892/or.2013.2641
22137559	Expression and clinical significance of ezrin in non--small-cell lung cancer.	Clin Lung Cancer	2012 May	Zhang XQ	doi: 10.1016/j.cllc.2011.04.002
26419932	miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression.	J Exp Clin Cancer Res	2015 Sep 29	Yu N	doi: 10.1186/s13046-015-0224-8.
18155831	Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells.	Cancer Lett	2008 Mar 8	Li Q	-
21818323	17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.	PLoS One	2011	Zheng S	doi: 10.1371/journal.pone.0022439
20501702	Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.	J Cell Sci	2010 Jun 15	Gavert N	doi: 10.1242/jcs.069542
23752190	Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation.	Oncogene	2014 May 1	Brown L	doi: 10.1038/onc.2013.186
22869145	Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-??B signaling that promotes colon cancer progression.	Oncogene	2013 Jul 4	Ben-Shmuel A	doi: 10.1038/onc.2012.340
26799186	CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering.	Oncotarget	2016 Feb 9	Singh R	doi: 10.18632/oncotarget.6944.
23435957	Silence of ezrin modifies migration and actin cytoskeleton rearrangements and enhances chemosensitivity of lung cancer cells in vitro.	Mol Cell Biochem	2013 May	Chen QY	doi: 10.1007/s11010-013-1586-x
26010871	Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells.	PLoS One	2015 May 26	Iessi E	doi: 10.1371/journal.pone.0126526
22476538	Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids.	Clin Exp Metastasis	2012 Aug	Konstantinovsky S	doi: 10.1007/s10585-012-9468-2
24885195	Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.	BMC Urol	2014 May 12	Andersson G	doi: 10.1186/1471-2490-14-36.
24728215	The expression and phosphorylation of ezrin and merlin in human pancreatic cancer.	Int J Oncol	2014 Jun	Zhou J	doi: 10.3892/ijo.2014.2381
20010876	Ezrin mediates c-Myc actions in prostate cancer cell invasion.	Oncogene	2010 Mar 11	Chuan YC	doi: 10.1038/onc.2009.442
21717114	Ezrin is associated with gastric cancer progression and prognosis.	Pathol Oncol Res	2011 Dec	Li L	doi: 10.1007/s12253-011-9402-y
18840437	MicroRNA-183 regulates Ezrin expression in lung cancer cells.	FEBS Lett	2008 Oct 29	Wang G	doi: 10.1016/j.febslet.2008.09.051
23098471	Knockdown of Ezrin by RNA interference reverses malignant behavior of human pancreatic cancer cells in vitro.	Asian Pac J Cancer Prev	2012	Zhong ZQ	-
21190723	Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer.	Hum Pathol	2011 Mar	Korkeila EA	doi: 10.1016/j.humpath.2010.08.004
26936397	Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells.	Neoplasia	2016 Feb	Saygideer-Kont Y	doi: 10.1016/j.neo.2016.01.002.
27823775	Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas.	Acta Histochem	2016 Oct	Demacopulo B	doi: 10.1016/j.acthis.2016.10.002
22234584	Ezrin expression in rectal cancer predicts time to development of local recurrence.	Int J Colorectal Dis	2012 Jul	Jrgren F	doi: 10.1007/s00384-011-1397-z
23067217	Altered expression of ezrin, E-Cadherin and β-Catenin in cervical neoplasia.	Neoplasma	2013	Auvinen E	doi: 10.4149/neo_2013_008.
20811677	Role for ezrin in breast cancer cell chemotaxis to CCL5.	Oncol Rep	2010 Oct	Li J	-
18852256	Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells.	Gut	2009 Feb	Kocher HM	doi: 10.1136/gut.2008.159871
23324233	[Effects of ezrin silencing on pancreatic cancer cell line Panc-1].	Zhonghua Bing Li Xue Za Zhi	2012 Dec	Meng YX	doi: 10.3760/cma.j.issn.0529-5807.2012.12.009.
23031255	Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.	Am J Pathol	2012 Dec	Donatello S	doi: 10.1016/j.ajpath.2012.08.025
23420497	ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.	Cell Oncol (Dordr)	2013 Jun	Halon A	doi: 10.1007/s13402-013-0125-9
27371852	[Silencing of ezrin gene inhibits proliferation and invasion of human prostate cancer PC-3 cells].	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi	2016 Jun	Yang N	-
21282970	Knockdown of ezrin via RNA interference suppresses Helicobacter pylori-enhanced invasion of gastric cancer cells.	Cancer Biol Ther	2011 Apr 15	Fan LL	-
20569470	Ezrin promotes invasion and metastasis of pancreatic cancer cells.	J Transl Med	2010 Jun 23	Meng Y	doi: 10.1186/1479-5876-8-61.
22199327	Carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological predictors.	Anticancer Res	2011 Dec	Korkeila EA	-
26209696	Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.	FASEB J	2015 Nov	Adada MM	doi: 10.1096/fj.15-274340
28953975	Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer.	PLoS One	2017 Sep 27	Slik K	doi: 10.1371/journal.pone.0185436
26933912	Ezrin contributes to cervical cancer progression through induction of epithelial-mesenchymal transition.	Oncotarget	2016 Apr 12	Kong J	doi: 10.18632/oncotarget.7779.
28535417	Ezrin/NF-kB activation regulates epithelial- mesenchymal transition induced by EGF and promotes metastasis of colorectal cancer.	Biomed Pharmacother	2017 Aug	Li Y	doi: 10.1016/j.biopha.2017.05.058
29587669	Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer.	BMC Cancer	2018 Mar 27	Zacapala-G??mez AE	doi: 10.1186/s12885-018-4243-7.
30463939	Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.	J Biol Chem	2019 Jan 18	Jeong J	doi: 10.1074/jbc.RA118.004143

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	158783632	Missense_Mutation	novel	Q196K	0.07
BLCA	chr6	158784646	Splice_Region	novel	L183L	0.13
BLCA	chr6	158770797	Missense_Mutation	novel	D353N	0.13
BLCA	chr6	158770777	Missense_Mutation	NA	K359N	0.06
BLCA	chr6	158767051	Nonsense_Mutation	novel	R542*	0.27
BLCA	chr6	158767009	Missense_Mutation	rs374282651	E556K	0.41
BLCA	chr6	158771303	Missense_Mutation	NA	I300M	0.28
BLCA	chr6	158818211	5'UTR	novel		0.55
BLCA	chr6	158789335	Missense_Mutation	novel	E17Q	0.46
BLCA	chr6	158785317	Silent	novel	I153I	0.15
BLCA	chr6	158783632	Nonsense_Mutation	NA	Q196*	0.2
BLCA	chr6	158767445	Frame_Shift_Del	novel	*P471Rfs11**	0.24
BRCA	chr6	158784691	Nonsense_Mutation	novel	W168*	0.1
BRCA	chr6	158818125	5'UTR	novel		0.38
BRCA	chr6	158769895	Missense_Mutation	novel	K380N	0.16
BRCA	chr6	158776457	Missense_Mutation	NA	S249F	0.39
BRCA	chr6	158818118	5'UTR	novel		0.23
BRCA	chr6	158767067	Silent	rs537707819	S536S	0.27
CESC	chr6	158769389	Missense_Mutation	NA	K427N	0.22
CESC	chr6	158766990	Missense_Mutation	novel	R562Q	0.17
CESC	chr6	158765991	3'UTR	novel		0.24
CESC	chr6	158767476	Missense_Mutation	NA	E461K	0.53
CESC	chr6	158770770	Missense_Mutation	NA	E362K	0.38
CESC	chr6	158785391	Missense_Mutation	rs528409234	A129T	0.36
CESC	chr6	158769360	Missense_Mutation	rs779204762	R437H	0.31
CESC	chr6	158789307	Missense_Mutation	NA	G26E	0.33
CHOL	chr6	158787166	Missense_Mutation	novel	F45C	0.61
COAD	chr6	158785535	Missense_Mutation	rs369743003	R81W	0.25
COAD	chr6	158767075	Silent	novel	L534L	0.27
COAD	chr6	158785396	Missense_Mutation	NA	S127F	0.35
COAD	chr6	158789471	Intron	novel		0.39
COAD	chr6	158787121	Missense_Mutation	NA	K60M	0.19
COAD	chr6	158767418	Missense_Mutation	novel	P480Q	0.33
COAD	chr6	158785396	Missense_Mutation	NA	S127F	0.16
COAD	chr6	158769872	Missense_Mutation	rs571220845	R388H	0.33
DLBC	chr6	158766899	3'UTR	novel		0.14
GBM	chr6	158789371	Missense_Mutation	NA	I5V	0.24
GBM	chr6	158785571	Nonsense_Mutation	NA	E69*	0.38
GBM	chr6	158769335	Missense_Mutation	novel	W445C	0.49
GBM	chr6	158776495	Silent	novel	P236P	0.1
HNSC	chr6	158766992	Silent	novel	G561G	0.27
HNSC	chr6	158767354	Silent	rs149944596	A501A	0.21
HNSC	chr6	158766853	3'UTR	novel		0.13
KIRC	chr6	158783657	Frame_Shift_Del	novel	*N186Kfs6**	0.25
KIRP	chr6	158767063	Missense_Mutation	NA	L538V	0.34
KIRP	chr6	158767357	Missense_Mutation	novel	S500R	0.05
LAML	chr6	158785522	Missense_Mutation	novel	Y85F	0.07
LGG	chr6	158766926	Silent	rs778831723	F583F	0.44
LGG	chr6	158769361	Missense_Mutation	rs748310556	R437C	0.15
LGG	chr6	158769796	Silent	rs145874025	S413S	0.29
LGG	chr6	158767378	Silent	rs201524101	G493G	0.34
LIHC	chr6	158785548	Silent	NA	L76L	0.39
LIHC	chr6	158789331	Missense_Mutation	NA	F18Y	0.29
LUAD	chr6	158769367	Missense_Mutation	rs770216148	R435W	0.08
LUAD	chr6	158785320	Silent	NA	L152L	0.17
LUAD	chr6	158767048	Missense_Mutation	novel	D543H	0.08
LUAD	chr6	158767284	Missense_Mutation	rs781182006	E525K	0.27
LUAD	chr6	158767025	Missense_Mutation	NA	N550K	0.42
LUSC	chr6	158818155	5'UTR	novel		0.18
LUSC	chr6	158770854	Missense_Mutation	novel	E334K	0.44
LUSC	chr6	158785313	Nonsense_Mutation	novel	Q155*	0.06
LUSC	chr6	158767414	Silent	novel	V481V	0.14
OV	chr6	158770870	Missense_Mutation	novel	K328N	0.05
OV	chr6	158767312	Missense_Mutation	NA	E515D	0.28
OV	chr6	158776454	Missense_Mutation	novel	F250C	0.06
PAAD	chr6	158776450	Silent	novel	N251N	0.03
READ	chr6	158769815	Missense_Mutation	NA	A407V	0.42
SARC	chr6	158770828	Silent	novel	R342R	0.08
SKCM	chr6	158767465	Silent	novel	H464H	0.16
SKCM	chr6	158767466	Missense_Mutation	novel	H464L	0.17
SKCM	chr6	158785446	Silent	NA	I110I	0.27
SKCM	chr6	158767429	Frame_Shift_Del	novel	*V477Cfs5**	0.38
SKCM	chr6	158785552	Missense_Mutation	rs11550707	P75L	0.27
SKCM	chr6	158767053	Missense_Mutation	novel	A541V	0.16
SKCM	chr6	158784678	Nonsense_Mutation	novel	Q173*	0.63
SKCM	chr6	158785445	Missense_Mutation	NA	L111F	0.38
SKCM	chr6	158767429	Silent	rs199951315	P476P	0.31
SKCM	chr6	158771313	Missense_Mutation	NA	P297L	0.62
SKCM	chr6	158785445	Missense_Mutation	NA	L111F	0.58
SKCM	chr6	158785536	Silent	NA	F80F	0.38
SKCM	chr6	158771363	Silent	novel	I280I	0.27
SKCM	chr6	158818217	5'UTR	novel		1
SKCM	chr6	158818218	5'UTR	novel		1
STAD	chr6	158770858	Silent	rs183636404	T332T	0.24
STAD	chr6	158785484	Missense_Mutation	NA	T98A	0.43
STAD	chr6	158784720	Missense_Mutation	novel	D159N	0.46
STAD	chr6	158784707	Missense_Mutation	NA	L163R	0.11
STAD	chr6	158785420	Frame_Shift_Del	NA	*P119Lfs34**	0.19
STAD	chr6	158783563	Missense_Mutation	NA	G219R	0.08
STAD	chr6	158789468	Intron	novel		0.07
STAD	chr6	158785283	Splice_Site	novel	X153_splice	0.2
THCA	chr6	158785466	Missense_Mutation	NA	L104F	0.26
UCEC	chr6	158776459	Silent	NA	I248I	0.28
UCEC	chr6	158771326	Missense_Mutation	rs749396044	R293C	0.36
UCEC	chr6	158769369	Missense_Mutation	rs372349918	A434V	0.36
UCEC	chr6	158766524	3'UTR	rs571928743		0.52
UCEC	chr6	158767402	Silent	novel	V485V	0.44
UCEC	chr6	158767357	Silent	rs546586987	S500S	0.05
UCEC	chr6	158766969	Missense_Mutation	rs146322319	R569Q	0.49
UCEC	chr6	158771245	Missense_Mutation	novel	R320W	0.38
UCEC	chr6	158770828	Silent	rs772879132	R342R	0.08
UCEC	chr6	158785334	Missense_Mutation	novel	S148R	0.22
UCEC	chr6	158766919	Missense_Mutation	NA	L586M	0.58
UCEC	chr6	158770865	Missense_Mutation	NA	R330T	0.17
UCEC	chr6	158771310	Missense_Mutation	novel	D298G	0.21
UCEC	chr6	158783599	Missense_Mutation	novel	E207K	0.45
UCEC	chr6	158784721	Missense_Mutation	novel	M158I	0.3
UCEC	chr6	158766565	3'UTR	rs540332956		0.32
UCEC	chr6	158771385	Missense_Mutation	NA	R273H	0.3
UCEC	chr6	158769899	Missense_Mutation	novel	R379M	0.22
UCEC	chr6	158771300	Missense_Mutation	novel	E301D	0.41
UCEC	chr6	158771391	Missense_Mutation	novel	A271D	0.28
UCEC	chr6	158766416	3'UTR	novel		0.3
UCEC	chr6	158766803	3'UTR	novel		0.37
UCEC	chr6	158769393	Missense_Mutation	rs767132690	A426V	0.48
UCEC	chr6	158766150	3'UTR	novel		0.28
UCEC	chr6	158785362	Silent	NA	N138N	0.39
UCEC	chr6	158766113	3'UTR	novel		0.31
UCEC	chr6	158767278	Missense_Mutation	novel	V527M	0.42
UCEC	chr6	158766926	Silent	rs778831723	F583F	0.35
UCEC	chr6	158769940	Silent	novel	L365L	0.37
UCEC	chr6	158765902	3'UTR	novel		0.43
UCEC	chr6	158767322	Missense_Mutation	rs748599655	R512H	0.6
UCEC	chr6	158769873	Missense_Mutation	NA	R388C	0.15
UCEC	chr6	158766926	Silent	rs778831723	F583F	0.14
UCEC	chr6	158766853	3'UTR	rs540272246		0.16
UCEC	chr6	158785420	Frame_Shift_Del	NA	*P119Lfs34**	0.48
UCEC	chr6	158771382	Missense_Mutation	novel	L274R	0.34
UCEC	chr6	158767429	Silent	rs199951315	P476P	0.31
UCEC	chr6	158769872	Missense_Mutation	rs571220845	R388H	0.21
UCEC	chr6	158789362	Nonsense_Mutation	novel	R8*	0.19
UCEC	chr6	158766146	3'UTR	novel		0.38
UCEC	chr6	158766115	3'UTR	novel		0.3
UCEC	chr6	158767355	Missense_Mutation	rs144164935	A501V	0.41
UCEC	chr6	158769843	Missense_Mutation	rs780497444	R398W	0.44
UCS	chr6	158767445	Frame_Shift_Del	novel	*P471Rfs11**	0.7

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3627	0.00027473
CESC	DEL	0.2881	9.8477e-05
KIRC	DEL	0.2481	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0054594
MESO	DEL	0.4023	0.0023534
PAAD	DEL	0.375	0.11274
SKCM	DEL	0.545	1.5442e-06
TGCT	DEL	0.0933	0.0031874
THYM	DEL	0.1382	0.10691

Survival Analysis

Cancer	P-value	Q-value
THYM	0.031	Kaplan-Meier Survival Analysis
KIRC	0.00013	Kaplan-Meier Survival Analysis
HNSC	0.0021	Kaplan-Meier Survival Analysis
BRCA	0.013	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
PAAD	0.00015	Kaplan-Meier Survival Analysis
READ	0.024	Kaplan-Meier Survival Analysis
LAML	0.0029	Kaplan-Meier Survival Analysis
LIHC	0.0075	Kaplan-Meier Survival Analysis
THCA	0.03	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis
OV	0.047	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000092820 (Gene tree)
Gene ID: 7430
Gene Symbol: EZR
Alias: VIL2
Full Name: ezrin
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 53,684 bases
Position: chr6:158,765,741-158,819,424
Accession: 12691
Summary: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10385389	Estrogen receptor regulation of the Na+/H+ exchange regulatory factor.	Endocrinology	1999 Jul	Ediger TR	-
22577345	The ezrin metastatic phenotype is associated with the initiation of protein translation.	Neoplasia	2012 Apr	Briggs JW	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367075	EZR-202	3096	-	ENSP00000356042	586 (aa)	-	P15311
ENST00000337147	EZR-201	3068	-	ENSP00000338934	586 (aa)	-	P15311
ENST00000392177	EZR-203	2933	XM_011536110	ENSP00000376016	586 (aa)	XP_011534412	E7EQR4
ENST00000476189	EZR-204	956	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000092820	lipoprotein A-I	2.53225E-07	19124843

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000092820	rs9347258	6	158812011	T	Hair color	29662168	[0.043-0.055] unit decrease	0.049	EFO_0007822
ENSG00000092820	rs3212308	6	158770756	?	Blond vs. brown/black hair color	30531825	NR	1.1275228	EFO_0003924
ENSG00000092820	rs9347258	6	158812011	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092820's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092820	EZR	100	76.280	ENSG00000137710	RDX	100	84.483	Homo_sapiens
ENSG00000092820	EZR	100	73.038	ENSG00000147065	MSN	100	86.408	Homo_sapiens
ENSG00000092820	EZR	100	96.587	ENSMUSG00000052397	Ezr	100	96.587	Mus_musculus
ENSG00000092820	EZR	100	76.280	ENSMUSG00000032050	Rdx	93	84.022	Mus_musculus
ENSG00000092820	EZR	100	73.424	ENSMUSG00000031207	Msn	100	73.424	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	20551903.	IMP	Process
GO:0001650	fibrillar center	-	IDA	Component
GO:0001726	ruffle	9852149.25554515.	IDA	Component
GO:0001772	immunological synapse	20551903.	IDA	Component
GO:0001772	immunological synapse	17911601.	IDA	Component
GO:0001931	uropod	-	IEA	Component
GO:0001951	intestinal D-glucose absorption	-	IEA	Process
GO:0003376	sphingosine-1-phosphate receptor signaling pathway	23106337.	IMP	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003779	actin binding	17825285.	IDA	Function
GO:0005515	protein binding	7844168.10793131.10806479.11598191.12651155.15020681.15498789.17046996.17242191.17911601.18046454.19555689.20195357.20442317.20551903.21148287.22570591.22805611.23414517.24555568.25554515.25591774.26496610.29568061.	IPI	Function
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005737	cytoplasm	23106337.25554515.25591774.	IDA	Component
GO:0005768	endosome	21148287.	IDA	Component
GO:0005829	cytosol	9852149.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005884	actin filament	11598191.	IDA	Component
GO:0005886	plasma membrane	23106337.	IDA	Component
GO:0005902	microvillus	12082081.	IDA	Component
GO:0005903	brush border	-	ISS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21282464.	IDA	Component
GO:0007016	cytoskeletal anchoring at plasma membrane	10793131.	NAS	Process
GO:0007159	leukocyte cell-cell adhesion	12082081.	IEP	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0008017	microtubule binding	23857773.	IMP	Function
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0008360	regulation of cell shape	20551903.	IMP	Process
GO:0008361	regulation of cell size	22467863.	IMP	Process
GO:0010628	positive regulation of gene expression	23264465.	IGI	Process
GO:0010737	protein kinase A signaling	17911601.	IMP	Process
GO:0015629	actin cytoskeleton	10793131.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016323	basolateral plasma membrane	-	ISS	Component
GO:0016324	apical plasma membrane	17825285.22797597.24862762.	IDA	Component
GO:0019898	extrinsic component of membrane	7844168.	IDA	Component
GO:0019904	protein domain specific binding	25554515.	IPI	Function
GO:0022612	gland morphogenesis	24862762.	IMP	Process
GO:0022614	membrane to membrane docking	12082081.	IEP	Process
GO:0030033	microvillus assembly	22797597.	IMP	Process
GO:0030175	filopodium	12082081.23106337.	IDA	Component
GO:0030315	T-tubule	-	IEA	Component
GO:0030863	cortical cytoskeleton	11598191.	TAS	Component
GO:0030953	astral microtubule organization	20551903.	IMP	Process
GO:0031528	microvillus membrane	-	IEA	Component
GO:0031532	actin cytoskeleton reorganization	23106337.	IMP	Process
GO:0031623	receptor internalization	-	IEA	Process
GO:0031982	vesicle	19190083.	HDA	Component
GO:0032532	regulation of microvillus length	-	IEA	Process
GO:0032587	ruffle membrane	-	IEA	Component
GO:0032956	regulation of actin cytoskeleton organization	20551903.	IMP	Process
GO:0032991	protein-containing complex	25097019.	IDA	Component
GO:0034236	protein kinase A catalytic subunit binding	17911601.	IPI	Function
GO:0034237	protein kinase A regulatory subunit binding	17911601.	IPI	Function
GO:0034629	cellular protein-containing complex localization	20551903.	IMP	Process
GO:0036064	ciliary basal body	-	IEA	Component
GO:0040018	positive regulation of multicellular organism growth	-	IEA	Process
GO:0042802	identical protein binding	21988832.29568061.	IPI	Function
GO:0042995	cell projection	25889165.	IDA	Component
GO:0043622	cortical microtubule organization	20551903.	IMP	Process
GO:0044297	cell body	-	IEA	Component
GO:0044393	microspike	-	IEA	Component
GO:0044548	S100 protein binding	25554515.	IPI	Function
GO:0044853	plasma membrane raft	17911601.	IDA	Component
GO:0045177	apical part of cell	12082081.	IDA	Component
GO:0045198	establishment of epithelial cell apical/basal polarity	22797597.24862762.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046847	filopodium assembly	23106337.	IMP	Process
GO:0048015	phosphatidylinositol-mediated signaling	25591774.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	24862762.	IDA	Component
GO:0050714	positive regulation of protein secretion	25591774.	IMP	Process
GO:0050839	cell adhesion molecule binding	12082081.15498789.	IPI	Function
GO:0050860	negative regulation of T cell receptor signaling pathway	20551903.	IMP	Process
GO:0051015	actin filament binding	10793131.	IDA	Function
GO:0051017	actin filament bundle assembly	10793131.	IDA	Process
GO:0051018	protein kinase A binding	25097019.	IPI	Function
GO:0051117	ATPase binding	17825285.	IPI	Function
GO:0051286	cell tip	-	IEA	Component
GO:0051660	establishment of centrosome localization	20551903.	IMP	Process
GO:0061028	establishment of endothelial barrier	23264465.	IGI	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0070373	negative regulation of ERK1 and ERK2 cascade	20551903.	IMP	Process
GO:0071320	cellular response to cAMP	17911601.	IMP	Process
GO:0071437	invadopodium	25486435.	IDA	Component
GO:0071944	cell periphery	22291017.	IDA	Component
GO:0072659	protein localization to plasma membrane	17825285.17911601.	IMP	Process
GO:0072697	protein localization to cell cortex	25554515.	IMP	Process
GO:0097449	astrocyte projection	-	IEA	Component
GO:0097454	Schwann cell microvillus	-	IEA	Component
GO:0097718	disordered domain specific binding	-	IEA	Function
GO:0098592	cytoplasmic side of apical plasma membrane	25591774.	IDA	Component
GO:1900041	negative regulation of interleukin-2 secretion	17911601.	IMP	Process
GO:1901222	regulation of NIK/NF-kappaB signaling	20551903.	IMP	Process
GO:1902115	regulation of organelle assembly	21148287.	IGI	Process
GO:1902115	regulation of organelle assembly	21148287.	IMP	Process
GO:1902896	terminal web assembly	-	IEA	Process
GO:1902966	positive regulation of protein localization to early endosome	21148287.	IGI	Process
GO:1903078	positive regulation of protein localization to plasma membrane	-	IEA	Process
GO:1903364	positive regulation of cellular protein catabolic process	21148287.	IGI	Process
GO:1903753	negative regulation of p38MAPK cascade	20551903.	IMP	Process
GO:2000643	positive regulation of early endosome to late endosome transport	21148287.	IGI	Process
GO:2000643	positive regulation of early endosome to late endosome transport	21148287.	IMP	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

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