EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21465252Ezrin expression as a prognostic marker in colorectal adenocarcinoma.Pathol Oncol Res2011 DecPatara Mdoi: 10.1007/s12253-011-9389-4
22415480Atypical ezrin localization as a marker of locally advanced breast cancer.Breast Cancer Res Treat2012 AugArslan AAdoi: 10.1007/s10549-012-2017-5
25337200miR-183 inhibits invasion of gastric cancer by targeting Ezrin.Int J Clin Exp Pathol2014 Aug 15Cao LL-
21352885ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.Biochimie2011 MayOu-Yang Mdoi: 10.1016/j.biochi.2011.01.017
21868260Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression.Urol Oncol2013 AugAthanasopoulou Adoi: 10.1016/j.urolonc.2011.07.003
17370040Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases.Clin Exp Metastasis2007Deng X-
18725408Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration.J Biol Chem2008 Oct 24Austermann Jdoi: 10.1074/jbc.M806145200
16633060Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma.Int J Gynecol Pathol2006 AprKbel M-
17370041Expression of the cytoskeleton linker protein ezrin in human cancers.Clin Exp Metastasis2007Bruce B-
19366061Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw.Tumori2009 Jan-FebPark HR-
21849257Immunohistochemical expression of ezrin in cutaneous basal and squamous cell carcinomas.Ann Diagn Pathol2011 DecAbdou AGdoi: 10.1016/j.anndiagpath.2011.05.005
19786985Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death.Cell Res2009 DecWang Sdoi: 10.1038/cr.2009.114
20128822Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.Cancer Sci2010 MarLing ZQdoi: 10.1111/j.1349-7006.2009.01470.x
23894313Prognostic value of Ezrin in solid tumors: a meta-analysis of the literature.PLoS One2013 Jul 19Han Kdoi: 10.1371/journal.pone.0068527
22629406Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity.PLoS One2012Zaarour RFdoi: 10.1371/journal.pone.0037490
23708420Association between ezrin protein expression and the prognosis of colorectal adenocarcinoma.Mol Med Rep2013 JulLin LJdoi: 10.3892/mmr.2013.1490
21971708Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors.Mol Med Rep2012 JanWeng WHdoi: 10.3892/mmr.2011.609
23422152Ezrin gene expression and protein production in the CD44(+) subpopulation of SCC-9 cells in a malignant oral cancer cell line in vitro.J Oral Maxillofac Surg2013 MarWu Gdoi: 10.1016/j.joms.2012.11.011.
16554733Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas.Mod Pathol2006 AprKbel M-
27622508Ezrin Is Associated with Disease Progression in Ovarian Carcinoma.PLoS One2016 Sep 13Horwitz Vdoi: 10.1371/journal.pone.0162502
28603065A decision tree-based combination of ezrin-interacting proteins to estimate the prognostic risk of patients with esophageal squamous cell carcinoma.Hum Pathol2017 AugHe JZdoi: 10.1016/j.humpath.2017.06.003
28624994Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.Clin Exp Metastasis2017 JunBartova Mdoi: 10.1007/s10585-017-9853-y
27793041CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.Oncotarget2016 Nov 29Riecken LBdoi: 10.18632/oncotarget.12919.
30226564Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin.Int J Mol Med2018 NovYan Hdoi: 10.3892/ijmm.2018.3853
18701134Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer.Hum Pathol2008 DecElzagheid Adoi: 10.1016/j.humpath.2008.04.020
19399936High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy.World J Gastroenterol2009 Apr 28Wang HJ-
22967445[Expression of ezrin in human non-small cell lung cancer and its relationship with metastasis and prognosis].Zhonghua Zhong Liu Za Zhi2012 JunChen QYdoi: 10
25278252Incident urothelial cancer in the Malm Diet and Cancer Study: cohort characteristics and further validation of ezrin as a prognostic biomarker.Diagn Pathol2014 Oct 3Wennersten Cdoi: 10.1186/s13000-014-0189-5.
20872967Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.World J Gastroenterol2010 Oct 7He ZY-
19550117Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.Ai Zheng2009 FebMa L-
21176563[Potential role of ezrin and its related microRNA in ovarian cancer invasion and metastasis].Zhonghua Fu Chan Ke Za Zhi2010 OctLi J-
23900701Clinical implications of Ezrin and CD44 coexpression in breast cancer.Oncol Rep2013 OctMa Ldoi: 10.3892/or.2013.2641
22137559Expression and clinical significance of ezrin in non--small-cell lung cancer.Clin Lung Cancer2012 MayZhang XQdoi: 10.1016/j.cllc.2011.04.002
26419932miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression.J Exp Clin Cancer Res2015 Sep 29Yu Ndoi: 10.1186/s13046-015-0224-8.
18155831Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells.Cancer Lett2008 Mar 8Li Q-
2181832317β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.PLoS One2011Zheng Sdoi: 10.1371/journal.pone.0022439
20501702Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.J Cell Sci2010 Jun 15Gavert Ndoi: 10.1242/jcs.069542
23752190Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation.Oncogene2014 May 1Brown Ldoi: 10.1038/onc.2013.186
22869145Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-??B signaling that promotes colon cancer progression.Oncogene2013 Jul 4Ben-Shmuel Adoi: 10.1038/onc.2012.340
26799186CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering.Oncotarget2016 Feb 9Singh Rdoi: 10.18632/oncotarget.6944.
23435957Silence of ezrin modifies migration and actin cytoskeleton rearrangements and enhances chemosensitivity of lung cancer cells in vitro.Mol Cell Biochem2013 MayChen QYdoi: 10.1007/s11010-013-1586-x
26010871Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells.PLoS One2015 May 26Iessi Edoi: 10.1371/journal.pone.0126526
22476538Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids.Clin Exp Metastasis2012 AugKonstantinovsky Sdoi: 10.1007/s10585-012-9468-2
24885195Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.BMC Urol2014 May 12Andersson Gdoi: 10.1186/1471-2490-14-36.
24728215The expression and phosphorylation of ezrin and merlin in human pancreatic cancer.Int J Oncol2014 JunZhou Jdoi: 10.3892/ijo.2014.2381
20010876Ezrin mediates c-Myc actions in prostate cancer cell invasion.Oncogene2010 Mar 11Chuan YCdoi: 10.1038/onc.2009.442
21717114Ezrin is associated with gastric cancer progression and prognosis.Pathol Oncol Res2011 DecLi Ldoi: 10.1007/s12253-011-9402-y
18840437MicroRNA-183 regulates Ezrin expression in lung cancer cells.FEBS Lett2008 Oct 29Wang Gdoi: 10.1016/j.febslet.2008.09.051
23098471Knockdown of Ezrin by RNA interference reverses malignant behavior of human pancreatic cancer cells in vitro.Asian Pac J Cancer Prev2012Zhong ZQ-
21190723Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer.Hum Pathol2011 MarKorkeila EAdoi: 10.1016/j.humpath.2010.08.004
26936397Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells.Neoplasia2016 FebSaygideer-Kont Ydoi: 10.1016/j.neo.2016.01.002.
27823775Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas.Acta Histochem2016 OctDemacopulo Bdoi: 10.1016/j.acthis.2016.10.002
22234584Ezrin expression in rectal cancer predicts time to development of local recurrence.Int J Colorectal Dis2012 JulJrgren Fdoi: 10.1007/s00384-011-1397-z
23067217Altered expression of ezrin, E-Cadherin and β-Catenin in cervical neoplasia.Neoplasma2013Auvinen Edoi: 10.4149/neo_2013_008.
20811677Role for ezrin in breast cancer cell chemotaxis to CCL5.Oncol Rep2010 OctLi J-
18852256Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells.Gut2009 FebKocher HMdoi: 10.1136/gut.2008.159871
23324233[Effects of ezrin silencing on pancreatic cancer cell line Panc-1].Zhonghua Bing Li Xue Za Zhi2012 DecMeng YXdoi: 10.3760/cma.j.issn.0529-5807.2012.12.009.
23031255Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.Am J Pathol2012 DecDonatello Sdoi: 10.1016/j.ajpath.2012.08.025
23420497ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.Cell Oncol (Dordr)2013 JunHalon Adoi: 10.1007/s13402-013-0125-9
27371852[Silencing of ezrin gene inhibits proliferation and invasion of human prostate cancer PC-3 cells].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2016 JunYang N-
21282970Knockdown of ezrin via RNA interference suppresses Helicobacter pylori-enhanced invasion of gastric cancer cells.Cancer Biol Ther2011 Apr 15Fan LL-
20569470Ezrin promotes invasion and metastasis of pancreatic cancer cells.J Transl Med2010 Jun 23Meng Ydoi: 10.1186/1479-5876-8-61.
22199327Carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological predictors.Anticancer Res2011 DecKorkeila EA-
26209696Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.FASEB J2015 NovAdada MMdoi: 10.1096/fj.15-274340
28953975Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer.PLoS One2017 Sep 27Slik Kdoi: 10.1371/journal.pone.0185436
26933912Ezrin contributes to cervical cancer progression through induction of epithelial-mesenchymal transition.Oncotarget2016 Apr 12Kong Jdoi: 10.18632/oncotarget.7779.
28535417Ezrin/NF-kB activation regulates epithelial- mesenchymal transition induced by EGF and promotes metastasis of colorectal cancer.Biomed Pharmacother2017 AugLi Ydoi: 10.1016/j.biopha.2017.05.058
29587669Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer.BMC Cancer2018 Mar 27Zacapala-G??mez AEdoi: 10.1186/s12885-018-4243-7.
30463939Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.J Biol Chem2019 Jan 18Jeong Jdoi: 10.1074/jbc.RA118.004143

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr6158783632Missense_MutationnovelQ196K0.07
BLCAchr6158784646Splice_RegionnovelL183L0.13
BLCAchr6158770797Missense_MutationnovelD353N0.13
BLCAchr6158770777Missense_MutationNAK359N0.06
BLCAchr6158767051Nonsense_MutationnovelR542*0.27
BLCAchr6158767009Missense_Mutationrs374282651E556K0.41
BLCAchr6158771303Missense_MutationNAI300M0.28
BLCAchr61588182115'UTRnovel0.55
BLCAchr6158789335Missense_MutationnovelE17Q0.46
BLCAchr6158785317SilentnovelI153I0.15
BLCAchr6158783632Nonsense_MutationNAQ196*0.2
BLCAchr6158767445Frame_Shift_DelnovelP471Rfs*110.24
BRCAchr6158784691Nonsense_MutationnovelW168*0.1
BRCAchr61588181255'UTRnovel0.38
BRCAchr6158769895Missense_MutationnovelK380N0.16
BRCAchr6158776457Missense_MutationNAS249F0.39
BRCAchr61588181185'UTRnovel0.23
BRCAchr6158767067Silentrs537707819S536S0.27
CESCchr6158769389Missense_MutationNAK427N0.22
CESCchr6158766990Missense_MutationnovelR562Q0.17
CESCchr61587659913'UTRnovel0.24
CESCchr6158767476Missense_MutationNAE461K0.53
CESCchr6158770770Missense_MutationNAE362K0.38
CESCchr6158785391Missense_Mutationrs528409234A129T0.36
CESCchr6158769360Missense_Mutationrs779204762R437H0.31
CESCchr6158789307Missense_MutationNAG26E0.33
CHOLchr6158787166Missense_MutationnovelF45C0.61
COADchr6158785535Missense_Mutationrs369743003R81W0.25
COADchr6158767075SilentnovelL534L0.27
COADchr6158785396Missense_MutationNAS127F0.35
COADchr6158789471Intronnovel0.39
COADchr6158787121Missense_MutationNAK60M0.19
COADchr6158767418Missense_MutationnovelP480Q0.33
COADchr6158785396Missense_MutationNAS127F0.16
COADchr6158769872Missense_Mutationrs571220845R388H0.33
DLBCchr61587668993'UTRnovel0.14
GBMchr6158789371Missense_MutationNAI5V0.24
GBMchr6158785571Nonsense_MutationNAE69*0.38
GBMchr6158769335Missense_MutationnovelW445C0.49
GBMchr6158776495SilentnovelP236P0.1
HNSCchr6158766992SilentnovelG561G0.27
HNSCchr6158767354Silentrs149944596A501A0.21
HNSCchr61587668533'UTRnovel0.13
KIRCchr6158783657Frame_Shift_DelnovelN186Kfs*60.25
KIRPchr6158767063Missense_MutationNAL538V0.34
KIRPchr6158767357Missense_MutationnovelS500R0.05
LAMLchr6158785522Missense_MutationnovelY85F0.07
LGGchr6158766926Silentrs778831723F583F0.44
LGGchr6158769361Missense_Mutationrs748310556R437C0.15
LGGchr6158769796Silentrs145874025S413S0.29
LGGchr6158767378Silentrs201524101G493G0.34
LIHCchr6158785548SilentNAL76L0.39
LIHCchr6158789331Missense_MutationNAF18Y0.29
LUADchr6158769367Missense_Mutationrs770216148R435W0.08
LUADchr6158785320SilentNAL152L0.17
LUADchr6158767048Missense_MutationnovelD543H0.08
LUADchr6158767284Missense_Mutationrs781182006E525K0.27
LUADchr6158767025Missense_MutationNAN550K0.42
LUSCchr61588181555'UTRnovel0.18
LUSCchr6158770854Missense_MutationnovelE334K0.44
LUSCchr6158785313Nonsense_MutationnovelQ155*0.06
LUSCchr6158767414SilentnovelV481V0.14
OVchr6158770870Missense_MutationnovelK328N0.05
OVchr6158767312Missense_MutationNAE515D0.28
OVchr6158776454Missense_MutationnovelF250C0.06
PAADchr6158776450SilentnovelN251N0.03
READchr6158769815Missense_MutationNAA407V0.42
SARCchr6158770828SilentnovelR342R0.08
SKCMchr6158767465SilentnovelH464H0.16
SKCMchr6158767466Missense_MutationnovelH464L0.17
SKCMchr6158785446SilentNAI110I0.27
SKCMchr6158767429Frame_Shift_DelnovelV477Cfs*50.38
SKCMchr6158785552Missense_Mutationrs11550707P75L0.27
SKCMchr6158767053Missense_MutationnovelA541V0.16
SKCMchr6158784678Nonsense_MutationnovelQ173*0.63
SKCMchr6158785445Missense_MutationNAL111F0.38
SKCMchr6158767429Silentrs199951315P476P0.31
SKCMchr6158771313Missense_MutationNAP297L0.62
SKCMchr6158785445Missense_MutationNAL111F0.58
SKCMchr6158785536SilentNAF80F0.38
SKCMchr6158771363SilentnovelI280I0.27
SKCMchr61588182175'UTRnovel1
SKCMchr61588182185'UTRnovel1
STADchr6158770858Silentrs183636404T332T0.24
STADchr6158785484Missense_MutationNAT98A0.43
STADchr6158784720Missense_MutationnovelD159N0.46
STADchr6158784707Missense_MutationNAL163R0.11
STADchr6158785420Frame_Shift_DelNAP119Lfs*340.19
STADchr6158783563Missense_MutationNAG219R0.08
STADchr6158789468Intronnovel0.07
STADchr6158785283Splice_SitenovelX153_splice0.2
THCAchr6158785466Missense_MutationNAL104F0.26
UCECchr6158776459SilentNAI248I0.28
UCECchr6158771326Missense_Mutationrs749396044R293C0.36
UCECchr6158769369Missense_Mutationrs372349918A434V0.36
UCECchr61587665243'UTRrs5719287430.52
UCECchr6158767402SilentnovelV485V0.44
UCECchr6158767357Silentrs546586987S500S0.05
UCECchr6158766969Missense_Mutationrs146322319R569Q0.49
UCECchr6158771245Missense_MutationnovelR320W0.38
UCECchr6158770828Silentrs772879132R342R0.08
UCECchr6158785334Missense_MutationnovelS148R0.22
UCECchr6158766919Missense_MutationNAL586M0.58
UCECchr6158770865Missense_MutationNAR330T0.17
UCECchr6158771310Missense_MutationnovelD298G0.21
UCECchr6158783599Missense_MutationnovelE207K0.45
UCECchr6158784721Missense_MutationnovelM158I0.3
UCECchr61587665653'UTRrs5403329560.32
UCECchr6158771385Missense_MutationNAR273H0.3
UCECchr6158769899Missense_MutationnovelR379M0.22
UCECchr6158771300Missense_MutationnovelE301D0.41
UCECchr6158771391Missense_MutationnovelA271D0.28
UCECchr61587664163'UTRnovel0.3
UCECchr61587668033'UTRnovel0.37
UCECchr6158769393Missense_Mutationrs767132690A426V0.48
UCECchr61587661503'UTRnovel0.28
UCECchr6158785362SilentNAN138N0.39
UCECchr61587661133'UTRnovel0.31
UCECchr6158767278Missense_MutationnovelV527M0.42
UCECchr6158766926Silentrs778831723F583F0.35
UCECchr6158769940SilentnovelL365L0.37
UCECchr61587659023'UTRnovel0.43
UCECchr6158767322Missense_Mutationrs748599655R512H0.6
UCECchr6158769873Missense_MutationNAR388C0.15
UCECchr6158766926Silentrs778831723F583F0.14
UCECchr61587668533'UTRrs5402722460.16
UCECchr6158785420Frame_Shift_DelNAP119Lfs*340.48
UCECchr6158771382Missense_MutationnovelL274R0.34
UCECchr6158767429Silentrs199951315P476P0.31
UCECchr6158769872Missense_Mutationrs571220845R388H0.21
UCECchr6158789362Nonsense_MutationnovelR8*0.19
UCECchr61587661463'UTRnovel0.38
UCECchr61587661153'UTRnovel0.3
UCECchr6158767355Missense_Mutationrs144164935A501V0.41
UCECchr6158769843Missense_Mutationrs780497444R398W0.44
UCSchr6158767445Frame_Shift_DelnovelP471Rfs*110.7

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.36270.00027473
CESCDEL0.28819.8477e-05
KIRCDEL0.24817.439e-11
KIRPDEL0.10420.054498
LGGDEL0.14420.0054594
MESODEL0.40230.0023534
PAADDEL0.3750.11274
SKCMDEL0.5451.5442e-06
TGCTDEL0.09330.0031874
THYMDEL0.13820.10691

Survival Analysis
CancerP-value Q-value
THYM0.031

Kaplan-Meier Survival Analysis

KIRC0.00013

Kaplan-Meier Survival Analysis

HNSC0.0021

Kaplan-Meier Survival Analysis

BRCA0.013

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.017

Kaplan-Meier Survival Analysis

PAAD0.00015

Kaplan-Meier Survival Analysis

READ0.024

Kaplan-Meier Survival Analysis

LAML0.0029

Kaplan-Meier Survival Analysis

LIHC0.0075

Kaplan-Meier Survival Analysis

THCA0.03

Kaplan-Meier Survival Analysis

UVM0.017

Kaplan-Meier Survival Analysis

OV0.047

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000092820 (Gene tree)
Gene ID
7430
Gene Symbol
EZR
Alias
VIL2
Full Name
ezrin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
53,684 bases
Position
chr6:158,765,741-158,819,424
Accession
12691
RBP type
non-canonical RBP
Summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10385389Estrogen receptor regulation of the Na+/H+ exchange regulatory factor.Endocrinology1999 JulEdiger TR-
22577345The ezrin metastatic phenotype is associated with the initiation of protein translation.Neoplasia2012 AprBriggs JW-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000367075EZR-2023096-ENSP00000356042586 (aa)-P15311
ENST00000337147EZR-2013068-ENSP00000338934586 (aa)-P15311
ENST00000392177EZR-2032933XM_011536110ENSP00000376016586 (aa)XP_011534412E7EQR4
ENST00000476189EZR-204956--- (aa)--
Gene Model
Click here to download ENSG00000092820's gene model file
Pathways
Pathway IDPathway NameSource
hsa04530Tight junctionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04971Gastric acid secretionKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000092820lipoprotein A-I2.53225E-0719124843
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000092820rs93472586158812011THair color29662168[0.043-0.055] unit decrease0.049EFO_0007822
ENSG00000092820rs32123086158770756?Blond vs. brown/black hair color30531825NR1.1275228EFO_0003924
ENSG00000092820rs93472586158812011?Hair color30595370EFO_0007822
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092820's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000092820EZR10076.280ENSG00000137710RDX10084.483Homo_sapiens
ENSG00000092820EZR10073.038ENSG00000147065MSN10086.408Homo_sapiens
ENSG00000092820EZR10096.587ENSMUSG00000052397Ezr10096.587Mus_musculus
ENSG00000092820EZR10076.280ENSMUSG00000032050Rdx9384.022Mus_musculus
ENSG00000092820EZR10073.424ENSMUSG00000031207Msn10073.424Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II20551903.IMPProcess
GO:0001650fibrillar center-IDAComponent
GO:0001726ruffle9852149.25554515.IDAComponent
GO:0001772immunological synapse20551903.IDAComponent
GO:0001772immunological synapse17911601.IDAComponent
GO:0001931uropod-IEAComponent
GO:0001951intestinal D-glucose absorption-IEAProcess
GO:0003376sphingosine-1-phosphate receptor signaling pathway23106337.IMPProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003779actin binding17825285.IDAFunction
GO:0005515protein binding7844168.10793131.10806479.11598191.12651155.15020681.15498789.17046996.17242191.17911601.18046454.19555689.20195357.20442317.20551903.21148287.22570591.22805611.23414517.24555568.25554515.25591774.26496610.29568061.IPIFunction
GO:0005615extracellular space16502470.HDAComponent
GO:0005737cytoplasm23106337.25554515.25591774.IDAComponent
GO:0005768endosome21148287.IDAComponent
GO:0005829cytosol9852149.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005884actin filament11598191.IDAComponent
GO:0005886plasma membrane23106337.IDAComponent
GO:0005902microvillus12082081.IDAComponent
GO:0005903brush border-ISSComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion21282464.IDAComponent
GO:0007016cytoskeletal anchoring at plasma membrane10793131.NASProcess
GO:0007159leukocyte cell-cell adhesion12082081.IEPProcess
GO:0007411axon guidance-TASProcess
GO:0008017microtubule binding23857773.IMPFunction
GO:0008022protein C-terminus binding-IEAFunction
GO:0008360regulation of cell shape20551903.IMPProcess
GO:0008361regulation of cell size22467863.IMPProcess
GO:0010628positive regulation of gene expression23264465.IGIProcess
GO:0010737protein kinase A signaling17911601.IMPProcess
GO:0015629actin cytoskeleton10793131.IDAComponent
GO:0016020membrane19946888.HDAComponent
GO:0016323basolateral plasma membrane-ISSComponent
GO:0016324apical plasma membrane17825285.22797597.24862762.IDAComponent
GO:0019898extrinsic component of membrane7844168.IDAComponent
GO:0019904protein domain specific binding25554515.IPIFunction
GO:0022612gland morphogenesis24862762.IMPProcess
GO:0022614membrane to membrane docking12082081.IEPProcess
GO:0030033microvillus assembly22797597.IMPProcess
GO:0030175filopodium12082081.23106337.IDAComponent
GO:0030315T-tubule-IEAComponent
GO:0030863cortical cytoskeleton11598191.TASComponent
GO:0030953astral microtubule organization20551903.IMPProcess
GO:0031528microvillus membrane-IEAComponent
GO:0031532actin cytoskeleton reorganization23106337.IMPProcess
GO:0031623receptor internalization-IEAProcess
GO:0031982vesicle19190083.HDAComponent
GO:0032532regulation of microvillus length-IEAProcess
GO:0032587ruffle membrane-IEAComponent
GO:0032956regulation of actin cytoskeleton organization20551903.IMPProcess
GO:0032991protein-containing complex25097019.IDAComponent
GO:0034236protein kinase A catalytic subunit binding17911601.IPIFunction
GO:0034237protein kinase A regulatory subunit binding17911601.IPIFunction
GO:0034629cellular protein-containing complex localization20551903.IMPProcess
GO:0036064ciliary basal body-IEAComponent
GO:0040018positive regulation of multicellular organism growth-IEAProcess
GO:0042802identical protein binding21988832.29568061.IPIFunction
GO:0042995cell projection25889165.IDAComponent
GO:0043622cortical microtubule organization20551903.IMPProcess
GO:0044297cell body-IEAComponent
GO:0044393microspike-IEAComponent
GO:0044548S100 protein binding25554515.IPIFunction
GO:0044853plasma membrane raft17911601.IDAComponent
GO:0045177apical part of cell12082081.IDAComponent
GO:0045198establishment of epithelial cell apical/basal polarity22797597.24862762.IMPProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0046847filopodium assembly23106337.IMPProcess
GO:0048015phosphatidylinositol-mediated signaling25591774.IDAProcess
GO:0048471perinuclear region of cytoplasm24862762.IDAComponent
GO:0050714positive regulation of protein secretion25591774.IMPProcess
GO:0050839cell adhesion molecule binding12082081.15498789.IPIFunction
GO:0050860negative regulation of T cell receptor signaling pathway20551903.IMPProcess
GO:0051015actin filament binding10793131.IDAFunction
GO:0051017actin filament bundle assembly10793131.IDAProcess
GO:0051018protein kinase A binding25097019.IPIFunction
GO:0051117ATPase binding17825285.IPIFunction
GO:0051286cell tip-IEAComponent
GO:0051660establishment of centrosome localization20551903.IMPProcess
GO:0061028establishment of endothelial barrier23264465.IGIProcess
GO:0070062extracellular exosome20458337.23533145.HDAComponent
GO:0070373negative regulation of ERK1 and ERK2 cascade20551903.IMPProcess
GO:0071320cellular response to cAMP17911601.IMPProcess
GO:0071437invadopodium25486435.IDAComponent
GO:0071944cell periphery22291017.IDAComponent
GO:0072659protein localization to plasma membrane17825285.17911601.IMPProcess
GO:0072697protein localization to cell cortex25554515.IMPProcess
GO:0097449astrocyte projection-IEAComponent
GO:0097454Schwann cell microvillus-IEAComponent
GO:0097718disordered domain specific binding-IEAFunction
GO:0098592cytoplasmic side of apical plasma membrane25591774.IDAComponent
GO:1900041negative regulation of interleukin-2 secretion17911601.IMPProcess
GO:1901222regulation of NIK/NF-kappaB signaling20551903.IMPProcess
GO:1902115regulation of organelle assembly21148287.IGIProcess
GO:1902115regulation of organelle assembly21148287.IMPProcess
GO:1902896terminal web assembly-IEAProcess
GO:1902966positive regulation of protein localization to early endosome21148287.IGIProcess
GO:1903078positive regulation of protein localization to plasma membrane-IEAProcess
GO:1903364positive regulation of cellular protein catabolic process21148287.IGIProcess
GO:1903753negative regulation of p38MAPK cascade20551903.IMPProcess
GO:2000643positive regulation of early endosome to late endosome transport21148287.IGIProcess
GO:2000643positive regulation of early endosome to late endosome transport21148287.IMPProcess
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