EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20331627ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.Cancer Sci2010 JunYang JJdoi: 10.1111/j.1349-7006.2010.01537.x
29071797Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.Mol Carcinog2018 FebFeng Ydoi: 10.1002/mc.22748

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2173198144Intronnovel0.13
BLCAchr2173266155Nonsense_MutationnovelS603*0.76
BLCAchr2173266331Frame_Shift_DelnovelG662Afs*1700.22
BLCAchr2173198070Missense_MutationnovelL209F0.19
BLCAchr2173266303SilentNAL652L0.19
BLCAchr2173198192Intronnovel0.38
BLCAchr2173221237Intronnovel0.07
BLCAchr2173266398Missense_MutationnovelG684V0.38
BLCAchr2173266220Missense_MutationnovelQ625E0.11
BLCAchr2173182898Missense_MutationNAR98G0.15
BRCAchr2173266081SilentNAR578R0.22
BRCAchr2173091136Nonsense_MutationNAW35*0.19
BRCAchr2173232220Missense_MutationnovelK354R0.06
BRCAchr2173266565Missense_MutationNAP740S0.12
BRCAchr21732668403'UTRnovel0.13
BRCAchr2173091036Missense_Mutationrs565333842S2L0.27
BRCAchr2173221271IntronNA0.14
CESCchr2173187615Missense_MutationnovelS136L0.4
CESCchr2173221480IntronNA0.24
CESCchr2173221480IntronNA0.25
CESCchr2173229725Missense_MutationnovelD342N0.25
CESCchr2173191143Frame_Shift_DelnovelV183Gfs*180.06
CESCchr2173221510IntronNA0.14
CESCchr2173226757Intronnovel0.17
CESCchr2173198102Frame_Shift_DelNAN222Tfs*40.25
CESCchr2173221483Intronnovel0.2
CESCchr2173258795Missense_MutationNAE486K0.2
CESCchr2173239425Missense_MutationnovelE430K0.12
CESCchr2173209757Nonsense_MutationNAS258*0.29
CHOLchr2173197929Intronnovel0.33
CHOLchr2173221228Intronnovel0.18
COADchr2173169833Missense_MutationNAR63K0.38
COADchr2173203837Missense_MutationNAE237D0.34
COADchr2173221670Intronnovel0.31
COADchr2173232385Missense_MutationnovelR377W0.29
COADchr2173198102Frame_Shift_DelNAN222Tfs*40.33
COADchr2173209864Intronrs7568964460.41
COADchr2173232366Missense_MutationnovelE370D0.04
COADchr2173209897IntronNA0.23
COADchr2173221412IntronNA0.16
COADchr2173266263Missense_MutationnovelT639I0.07
COADchr2173091092Missense_MutationnovelN21D0.1
COADchr2173217194Nonsense_MutationnovelR311*0.2
DLBCchr2173197973Intronnovel0.63
ESCAchr2173209743Missense_MutationnovelF253L0.53
ESCAchr2173198102Frame_Shift_DelNAN222Tfs*40.46
ESCAchr2173266731Missense_Mutationrs761040219R795H0.16
GBMchr2173266631Frame_Shift_InsnovelK762Tfs*260.3
GBMchr2173209667Intronnovel0.13
GBMchr2173266694Missense_Mutationrs768503188A783T0.59
GBMchr2173209785Silentrs145549000T267T0.5
GBMchr2173232387SilentnovelR377R0.07
GBMchr2173266282Missense_MutationnovelK645N0.13
GBMchr2173258806Missense_MutationnovelK489N0.33
GBMchr2173239482Missense_MutationNAG449R0.3
HNSCchr2173266352Missense_MutationnovelE669Q0.21
HNSCchr2173239480Missense_MutationnovelP448R0.12
HNSCchr2173258735Missense_MutationnovelD466N0.33
HNSCchr2173232217Missense_MutationnovelR353T0.26
KIRCchr2173266691Frame_Shift_DelnovelA783Pfs*490.41
KIRCchr2173182945Missense_MutationnovelD113E0.23
KIRCchr2173198149Intronnovel0.06
KIRPchr2173232386Missense_MutationNAR377L0.61
LAMLchr2173169843Frame_Shift_DelnovelQ67Sfs*50.09
LGGchr21730910115'UTRrs1996569410.2
LGGchr2173266422Missense_MutationnovelP692H0.12
LGGchr2173266394Missense_Mutationrs180986176R683C0.35
LIHCchr2173182925Missense_Mutationrs759664582I107V0.4
LIHCchr2173091034Translation_Start_SitenovelM1?0.34
LIHCchr2173221578Intronnovel0.27
LUADchr2173266694Missense_MutationNAA783S0.22
LUADchr2173091097Silentrs147113074C22C0.38
LUADchr2173198202Intronnovel0.17
LUADchr2173266603SilentnovelT752T0.27
LUADchr2173266604Missense_MutationnovelD753Y0.26
LUADchr2173263821Missense_MutationnovelV543G0.11
LUADchr2173221270Intronnovel0.12
LUADchr2173266550Missense_MutationNAR735G0.33
LUADchr2173217210Missense_MutationnovelK316M0.34
LUADchr2173221302Intronnovel0.27
LUADchr2173221225Intronnovel0.16
LUADchr2173221486Intronnovel0.1
LUADchr2173221312Intronnovel0.18
LUADchr2173221464Intronnovel0.06
LUADchr2173221388Intronnovel0.12
LUADchr2173217202Missense_MutationNAR313S0.21
LUSCchr2173187584Missense_MutationnovelP126S0.28
LUSCchr2173266196Missense_Mutationrs750517616R617W0.28
LUSCchr2173169879SilentnovelY78Y0.32
LUSCchr2173191037Splice_Regionrs3744717820.08
LUSCchr2173203809Missense_MutationnovelP228L0.12
LUSCchr2173191125Missense_MutationnovelV177G0.18
LUSCchr2173190903Missense_MutationnovelA142S0.16
LUSCchr2173203862Missense_MutationnovelD246H0.04
LUSCchr2173266217Missense_MutationnovelY624H0.1
OVchr21732668353'UTRnovel0.1
OVchr2173232394Missense_MutationnovelL380M0.05
OVchr2173266609Frame_Shift_DelnovelR755Sfs*30.11
READchr2173209673Intronnovel0.29
READchr2173190892Splice_Regionnovel0.45
READchr2173239496Splice_RegionNAQ453Q0.59
READchr2173198102Frame_Shift_DelNAN222Tfs*40.4
READchr2173169862Missense_MutationNAL73I0.35
READchr2173191042Splice_RegionnovelI149I0.41
READchr2173197936Intronnovel0.46
READchr2173221406Intronnovel0.44
SARCchr2173266320Missense_MutationnovelG658D0.16
SARCchr2173226871Intronnovel0.91
SARCchr2173263795Missense_MutationnovelW534C0.1
SARCchr2173221165Intronnovel0.09
SKCMchr2173266136SilentnovelL597L0.53
SKCMchr2173198129Intronnovel0.53
SKCMchr2173229699Missense_MutationNAS333F0.17
SKCMchr2173182852Splice_SiteNAX83_splice0.16
SKCMchr2173221229IntronNA0.42
SKCMchr2173266293Missense_MutationNAS649F0.24
SKCMchr2173232212SilentNAL351L0.18
SKCMchr2173266489SilentnovelF714F0.29
SKCMchr2173239451SilentnovelL438L0.35
SKCMchr2173239452Missense_MutationnovelE439K0.32
SKCMchr2173266456SilentNAS703S0.21
SKCMchr2173266347Missense_MutationNAS667F0.26
SKCMchr2173266464Missense_Mutationrs376397839S706L0.23
SKCMchr2173198023Splice_Regionnovel0.22
SKCMchr2173209770SilentNAS262S0.32
SKCMchr2173198189Intronnovel0.25
SKCMchr2173261135Missense_MutationnovelE517K0.35
SKCMchr2173209724Splice_Regionnovel0.4
SKCMchr2173266176Missense_Mutationrs769862837S610F0.5
SKCMchr2173261077Missense_MutationnovelM497I0.25
STADchr2173221258Intronrs7605513040.25
STADchr2173209785Silentrs145549000T267T0.31
STADchr2173209785Silentrs145549000T267T0.09
STADchr2173239442Missense_MutationnovelI435M0.31
STADchr2173239411Missense_MutationNAG425V0.63
STADchr2173169862Missense_MutationNAL73I0.36
STADchr2173198122Intronrs7681591710.28
STADchr2173266127Missense_MutationNAN594D0.24
STADchr2173266364Missense_MutationNAY673N0.09
STADchr2173197992Intronnovel0.32
STADchr2173217222Frame_Shift_DelnovelK321Sfs*20.3
STADchr2173217215Missense_MutationnovelW318R0.25
STADchr2173187585Missense_MutationNAP126L0.19
STADchr2173182895Missense_Mutationrs746903757N97Y0.51
STADchr2173266693Silentrs746871474P782P0.24
THCAchr2173091189Frame_Shift_InsnovelA54Rfs*260.11
THCAchr2173209939Intronnovel0.09
UCECchr2173232194Nonsense_MutationNAY345*0.27
UCECchr2173239421SilentNAP428P0.33
UCECchr2173266477SilentnovelY710Y0.31
UCECchr2173217169SilentNAS302S0.32
UCECchr2173198079SilentnovelL212L0.45
UCECchr2173226765Intronnovel0.36
UCECchr2173266201SilentnovelP618P0.07
UCECchr2173263848Missense_MutationNAT552I0.52
UCECchr2173210018Intronnovel0.41
UCECchr2173217138Missense_MutationNAE292V0.49
UCECchr2173198177Intronnovel0.27
UCECchr2173222259Intronnovel0.32
UCECchr2173091126Missense_Mutationrs374943647R32Q0.39
UCECchr2173263888Silentrs772234268S565S0.38
UCECchr2173238406Missense_MutationnovelN413H0.22
UCECchr2173258750Missense_MutationnovelT471A0.1
UCECchr2173182875Missense_MutationNAL90P0.22
UCECchr2173187560Missense_MutationNAM118L0.43
UCECchr2173221163IntronNA0.28
UCECchr2173266639Silentrs770195520S764S0.32
UCECchr2173198122Intronrs7681591710.15
UCECchr2173091150Missense_MutationNAK40R0.44
UCECchr2173221154Intronnovel0.07
UCECchr2173209958Intronnovel0.2
UCECchr2173266288Missense_MutationnovelF647L0.33
UCECchr2173182880Missense_MutationnovelD92Y0.16
UCECchr2173209848Intronrs1914954040.42
UCECchr2173198741Intronrs7475369440.36
UCECchr2173226457Intronnovel0.38
UCECchr2173198102Frame_Shift_DelNAN222Tfs*40.29
UCECchr2173221576Intronnovel0.26
UCECchr2173226686Intronnovel0.14
UCECchr2173226941Intronnovel0.08
UCECchr2173226956Intronnovel0.13
UCECchr2173198714Intronnovel0.22
UCECchr2173209715Intronrs3724441020.33
UCECchr2173227118Intronnovel0.07
UCECchr2173226818Intronnovel0.25
UCECchr2173266196Missense_Mutationrs750517616R617W0.44
UCECchr2173222205Intronnovel0.53
UCECchr2173226860Intronnovel0.41
UCECchr2173226520Intronnovel0.48
UCECchr2173266127Missense_MutationNAN594D0.06
UCECchr2173266676Missense_MutationnovelP777S0.35
UCECchr2173226761Intronnovel0.3
UCECchr2173209670Intronnovel0.3
UCECchr2173266572Missense_MutationnovelT742I0.29
UCECchr21732667583'UTRnovel0.14
UCECchr2173221269Intronrs2011889330.26
UCECchr2173198773Intronnovel0.45
UCECchr2173221343Intronnovel0.24
UCECchr2173266288Silentrs772497418F647F0.4
UCECchr2173222470Intronnovel0.17
UCECchr2173258797Missense_MutationnovelE486D0.33
UCECchr2173222534Intronnovel0.38
UCECchr2173191173Missense_MutationnovelG193D0.43
UCECchr2173198102Frame_Shift_DelNAN222Tfs*40.38
UCECchr2173266440Frame_Shift_DelnovelK699Vfs*1320.08
UCECchr2173226678Intronnovel0.11
UCECchr2173187618Missense_MutationNAR137I0.28
UCECchr2173227007Intronnovel0.29
UCECchr2173266116Missense_Mutationrs200257993R590H0.17
UCECchr2173198212Intronnovel0.08
UCECchr2173222369Intronnovel0.33
UCECchr2173232195Missense_MutationnovelC346S0.46
UCECchr2173221620Intronnovel1
UCECchr2173221621Intronnovel1
UCECchr2173091061Missense_MutationNAQ10H0.42
UCECchr2173198122Intronrs7681591710.16
UCECchr2173198029Missense_MutationNAL196I0.19
UCECchr2173221544Intronnovel0.17
UCECchr2173197846Intronnovel0.52
UCECchr2173266515Missense_MutationnovelN723S0.16
UCECchr2173266638Missense_MutationnovelS764N0.43
UCECchr2173222411Intronnovel0.37
UCECchr2173217204Missense_MutationNAR314H0.17
UCECchr2173221491Intronrs3711481350.27
UCECchr2173266126SilentNAS593S0.26
UCECchr21730910315'UTRnovel0.23
UCECchr2173182946Missense_MutationnovelV114L0.33
UCECchr2173222183Intronnovel0.43
UCECchr2173222554Intronnovel0.47
UCECchr2173239449Silentrs780688121L438L0.33
UCSchr2173217204Missense_MutationnovelR314L0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.11530.012962
PAADAMP0.07070.1091
PAADDEL0.02720.2014

Survival Analysis
CancerP-value Q-value
SARC0.044

Kaplan-Meier Survival Analysis

MESO0.00024

Kaplan-Meier Survival Analysis

ACC0.005

Kaplan-Meier Survival Analysis

HNSC0.035

Kaplan-Meier Survival Analysis

LUSC0.04

Kaplan-Meier Survival Analysis

ESCA0.029

Kaplan-Meier Survival Analysis

KIRP0.00041

Kaplan-Meier Survival Analysis

COAD0.0042

Kaplan-Meier Survival Analysis

BLCA0.0028

Kaplan-Meier Survival Analysis

CESC0.042

Kaplan-Meier Survival Analysis

LAML0.039

Kaplan-Meier Survival Analysis

KICH0.011

Kaplan-Meier Survival Analysis

LIHC0.0039

Kaplan-Meier Survival Analysis

LUAD0.038

Kaplan-Meier Survival Analysis

UVM0.00064

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000091436 (Gene tree)
Gene ID
51776
Gene Symbol
MAP3K20
Alias
MLTKalpha|MLTKbeta|ZAK|MLTK|MLK7|MRK
Full Name
mitogen-activated protein kinase kinase kinase 20
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
192,576 bases
Position
chr2:173,075,435-173,268,010
Accession
17797
RBP type
non-canonical RBP
Summary
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000409176MAP3K20-2032572XM_005246640ENSP00000387259800 (aa)XP_005246697Q9NYL2
ENST00000476618MAP3K20-2064010--- (aa)--
ENST00000480606MAP3K20-207821--- (aa)--
ENST00000375213MAP3K20-2023741-ENSP00000364361800 (aa)-Q9NYL2
ENST00000468408MAP3K20-205585--- (aa)--
ENST00000338983MAP3K20-2017179XM_017004323ENSP00000340257455 (aa)XP_016859812Q9NYL2
ENST00000539448MAP3K20-2082312XM_017004324ENSP00000439414455 (aa)XP_016859813Q9NYL2
ENST00000422149MAP3K20-204661-ENSP00000411923138 (aa)-C9J3F7
Gene Model
Click here to download ENSG00000091436's gene model file
Pathways
Pathway IDPathway NameSource
hsa04010MAPK signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000091436Hemoglobins4.86540771444943E-517903294
ENSG00000091436Hemoglobins3.38333824896342E-517903294
ENSG00000091436Stroke4.1882393E-004-
ENSG00000091436Longevity1E-627015805
ENSG00000091436Adiponectin2E-626299439
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000091436rs7228642173118476GLung cancer28604730[1.05-1.11]1.0751604EFO_0001071
ENSG00000091436rs18666312173211033ALung cancer in ever smokers28604730[1.04-1.11]1.0744331EFO_0006527|EFO_0001071
ENSG00000091436rs49725392173242571?Parental longevity (mother's age at death)27015805[0.018-0.043] unit decrease0.03089EFO_0007796
ENSG00000091436rs104973992173249411?Adiponectin levels26299439EFO_0004502
ENSG00000091436rs101934982173229617AEducational attainment (MTAG)30038396[0.0087-0.0145] unit increase0.0116EFO_0004784
ENSG00000091436rs101934982173229617AHighest math class taken30038396[0.012-0.023] unit increase0.0175EFO_0004875
ENSG00000091436rs101934982173229617ASelf-reported math ability (MTAG)30038396[0.0094-0.0172] unit increase0.0133EFO_0004875
ENSG00000091436rs101934982173229617AHighest math class taken (MTAG)30038396[0.012-0.019] unit increase0.0154EFO_0004875
ENSG00000091436rs101934982173229617ACognitive performance (MTAG)30038396[0.013-0.024] unit increase0.0186EFO_0008354
ENSG00000091436rs101934982173229617AEducational attainment (years of education)30038396[0.0066-0.0128] unit increase0.0097EFO_0004784
ENSG00000091436rs75751892173150440ASmoking status (ever vs never smokers)30643258[0.0071-0.0151] unit decrease0.011123441EFO_0004318
ENSG00000091436rs130353662173194654?Lung function (FEV1/FVC)30595370EFO_0004713
ENSG00000091436rs67588592173100328TDiastolic blood pressure30224653[0.086-0.156] mmHg increase0.1211EFO_0006336
ENSG00000091436rs67508012173202452ASmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0048-0.0092] unit increase0.00698417EFO_0006527
ENSG00000091436rs130043452173172619CChronotype306968231.0190797EFO_0008328
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000091436's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000091436MAP3K2010099.275ENSMUSG00000004085Map3k20100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000077DNA damage checkpoint11836244.IMPProcess
GO:0000186activation of MAPKK activity11836244.TASProcess
GO:0000287magnesium ion binding11836244.IDAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0004674protein serine/threonine kinase activity11836244.IDAFunction
GO:0004709MAP kinase kinase kinase activity11836244.IDAFunction
GO:0005515protein binding21988832.IPIFunction
GO:0005524ATP binding11836244.IDAFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005829cytosol-IDAComponent
GO:0006468protein phosphorylation11836244.IDAProcess
GO:0007010cytoskeleton organization-IEAProcess
GO:0007050cell cycle arrest11836244.IMPProcess
GO:0007093mitotic cell cycle checkpoint15342622.IDAProcess
GO:0007257activation of JUN kinase activity11836244.IDAProcess
GO:0008219cell death11836244.NASProcess
GO:0008283cell proliferation11836244.NASProcess
GO:0030154cell differentiation11836244.NASProcess
GO:0042733embryonic digit morphogenesis26755636.IMPProcess
GO:0043065positive regulation of apoptotic process10924358.IDAProcess
GO:0051403stress-activated MAPK cascade11836244.IDAProcess
GO:0060173limb development26755636.IMPProcess
GO:0071480cellular response to gamma radiation11836244.IDAProcess
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