EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20331627	ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.	Cancer Sci	2010 Jun	Yang JJ	doi: 10.1111/j.1349-7006.2010.01537.x
29071797	Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.	Mol Carcinog	2018 Feb	Feng Y	doi: 10.1002/mc.22748

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	173198144	Intron	novel		0.13
BLCA	chr2	173266155	Nonsense_Mutation	novel	S603*	0.76
BLCA	chr2	173266331	Frame_Shift_Del	novel	*G662Afs170**	0.22
BLCA	chr2	173198070	Missense_Mutation	novel	L209F	0.19
BLCA	chr2	173266303	Silent	NA	L652L	0.19
BLCA	chr2	173198192	Intron	novel		0.38
BLCA	chr2	173221237	Intron	novel		0.07
BLCA	chr2	173266398	Missense_Mutation	novel	G684V	0.38
BLCA	chr2	173266220	Missense_Mutation	novel	Q625E	0.11
BLCA	chr2	173182898	Missense_Mutation	NA	R98G	0.15
BRCA	chr2	173266081	Silent	NA	R578R	0.22
BRCA	chr2	173091136	Nonsense_Mutation	NA	W35*	0.19
BRCA	chr2	173232220	Missense_Mutation	novel	K354R	0.06
BRCA	chr2	173266565	Missense_Mutation	NA	P740S	0.12
BRCA	chr2	173266840	3'UTR	novel		0.13
BRCA	chr2	173091036	Missense_Mutation	rs565333842	S2L	0.27
BRCA	chr2	173221271	Intron	NA		0.14
CESC	chr2	173187615	Missense_Mutation	novel	S136L	0.4
CESC	chr2	173221480	Intron	NA		0.24
CESC	chr2	173221480	Intron	NA		0.25
CESC	chr2	173229725	Missense_Mutation	novel	D342N	0.25
CESC	chr2	173191143	Frame_Shift_Del	novel	*V183Gfs18**	0.06
CESC	chr2	173221510	Intron	NA		0.14
CESC	chr2	173226757	Intron	novel		0.17
CESC	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.25
CESC	chr2	173221483	Intron	novel		0.2
CESC	chr2	173258795	Missense_Mutation	NA	E486K	0.2
CESC	chr2	173239425	Missense_Mutation	novel	E430K	0.12
CESC	chr2	173209757	Nonsense_Mutation	NA	S258*	0.29
CHOL	chr2	173197929	Intron	novel		0.33
CHOL	chr2	173221228	Intron	novel		0.18
COAD	chr2	173169833	Missense_Mutation	NA	R63K	0.38
COAD	chr2	173203837	Missense_Mutation	NA	E237D	0.34
COAD	chr2	173221670	Intron	novel		0.31
COAD	chr2	173232385	Missense_Mutation	novel	R377W	0.29
COAD	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.33
COAD	chr2	173209864	Intron	rs756896446		0.41
COAD	chr2	173232366	Missense_Mutation	novel	E370D	0.04
COAD	chr2	173209897	Intron	NA		0.23
COAD	chr2	173221412	Intron	NA		0.16
COAD	chr2	173266263	Missense_Mutation	novel	T639I	0.07
COAD	chr2	173091092	Missense_Mutation	novel	N21D	0.1
COAD	chr2	173217194	Nonsense_Mutation	novel	R311*	0.2
DLBC	chr2	173197973	Intron	novel		0.63
ESCA	chr2	173209743	Missense_Mutation	novel	F253L	0.53
ESCA	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.46
ESCA	chr2	173266731	Missense_Mutation	rs761040219	R795H	0.16
GBM	chr2	173266631	Frame_Shift_Ins	novel	*K762Tfs26**	0.3
GBM	chr2	173209667	Intron	novel		0.13
GBM	chr2	173266694	Missense_Mutation	rs768503188	A783T	0.59
GBM	chr2	173209785	Silent	rs145549000	T267T	0.5
GBM	chr2	173232387	Silent	novel	R377R	0.07
GBM	chr2	173266282	Missense_Mutation	novel	K645N	0.13
GBM	chr2	173258806	Missense_Mutation	novel	K489N	0.33
GBM	chr2	173239482	Missense_Mutation	NA	G449R	0.3
HNSC	chr2	173266352	Missense_Mutation	novel	E669Q	0.21
HNSC	chr2	173239480	Missense_Mutation	novel	P448R	0.12
HNSC	chr2	173258735	Missense_Mutation	novel	D466N	0.33
HNSC	chr2	173232217	Missense_Mutation	novel	R353T	0.26
KIRC	chr2	173266691	Frame_Shift_Del	novel	*A783Pfs49**	0.41
KIRC	chr2	173182945	Missense_Mutation	novel	D113E	0.23
KIRC	chr2	173198149	Intron	novel		0.06
KIRP	chr2	173232386	Missense_Mutation	NA	R377L	0.61
LAML	chr2	173169843	Frame_Shift_Del	novel	*Q67Sfs5**	0.09
LGG	chr2	173091011	5'UTR	rs199656941		0.2
LGG	chr2	173266422	Missense_Mutation	novel	P692H	0.12
LGG	chr2	173266394	Missense_Mutation	rs180986176	R683C	0.35
LIHC	chr2	173182925	Missense_Mutation	rs759664582	I107V	0.4
LIHC	chr2	173091034	Translation_Start_Site	novel	M1?	0.34
LIHC	chr2	173221578	Intron	novel		0.27
LUAD	chr2	173266694	Missense_Mutation	NA	A783S	0.22
LUAD	chr2	173091097	Silent	rs147113074	C22C	0.38
LUAD	chr2	173198202	Intron	novel		0.17
LUAD	chr2	173266603	Silent	novel	T752T	0.27
LUAD	chr2	173266604	Missense_Mutation	novel	D753Y	0.26
LUAD	chr2	173263821	Missense_Mutation	novel	V543G	0.11
LUAD	chr2	173221270	Intron	novel		0.12
LUAD	chr2	173266550	Missense_Mutation	NA	R735G	0.33
LUAD	chr2	173217210	Missense_Mutation	novel	K316M	0.34
LUAD	chr2	173221302	Intron	novel		0.27
LUAD	chr2	173221225	Intron	novel		0.16
LUAD	chr2	173221486	Intron	novel		0.1
LUAD	chr2	173221312	Intron	novel		0.18
LUAD	chr2	173221464	Intron	novel		0.06
LUAD	chr2	173221388	Intron	novel		0.12
LUAD	chr2	173217202	Missense_Mutation	NA	R313S	0.21
LUSC	chr2	173187584	Missense_Mutation	novel	P126S	0.28
LUSC	chr2	173266196	Missense_Mutation	rs750517616	R617W	0.28
LUSC	chr2	173169879	Silent	novel	Y78Y	0.32
LUSC	chr2	173191037	Splice_Region	rs374471782		0.08
LUSC	chr2	173203809	Missense_Mutation	novel	P228L	0.12
LUSC	chr2	173191125	Missense_Mutation	novel	V177G	0.18
LUSC	chr2	173190903	Missense_Mutation	novel	A142S	0.16
LUSC	chr2	173203862	Missense_Mutation	novel	D246H	0.04
LUSC	chr2	173266217	Missense_Mutation	novel	Y624H	0.1
OV	chr2	173266835	3'UTR	novel		0.1
OV	chr2	173232394	Missense_Mutation	novel	L380M	0.05
OV	chr2	173266609	Frame_Shift_Del	novel	*R755Sfs3**	0.11
READ	chr2	173209673	Intron	novel		0.29
READ	chr2	173190892	Splice_Region	novel		0.45
READ	chr2	173239496	Splice_Region	NA	Q453Q	0.59
READ	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.4
READ	chr2	173169862	Missense_Mutation	NA	L73I	0.35
READ	chr2	173191042	Splice_Region	novel	I149I	0.41
READ	chr2	173197936	Intron	novel		0.46
READ	chr2	173221406	Intron	novel		0.44
SARC	chr2	173266320	Missense_Mutation	novel	G658D	0.16
SARC	chr2	173226871	Intron	novel		0.91
SARC	chr2	173263795	Missense_Mutation	novel	W534C	0.1
SARC	chr2	173221165	Intron	novel		0.09
SKCM	chr2	173266136	Silent	novel	L597L	0.53
SKCM	chr2	173198129	Intron	novel		0.53
SKCM	chr2	173229699	Missense_Mutation	NA	S333F	0.17
SKCM	chr2	173182852	Splice_Site	NA	X83_splice	0.16
SKCM	chr2	173221229	Intron	NA		0.42
SKCM	chr2	173266293	Missense_Mutation	NA	S649F	0.24
SKCM	chr2	173232212	Silent	NA	L351L	0.18
SKCM	chr2	173266489	Silent	novel	F714F	0.29
SKCM	chr2	173239451	Silent	novel	L438L	0.35
SKCM	chr2	173239452	Missense_Mutation	novel	E439K	0.32
SKCM	chr2	173266456	Silent	NA	S703S	0.21
SKCM	chr2	173266347	Missense_Mutation	NA	S667F	0.26
SKCM	chr2	173266464	Missense_Mutation	rs376397839	S706L	0.23
SKCM	chr2	173198023	Splice_Region	novel		0.22
SKCM	chr2	173209770	Silent	NA	S262S	0.32
SKCM	chr2	173198189	Intron	novel		0.25
SKCM	chr2	173261135	Missense_Mutation	novel	E517K	0.35
SKCM	chr2	173209724	Splice_Region	novel		0.4
SKCM	chr2	173266176	Missense_Mutation	rs769862837	S610F	0.5
SKCM	chr2	173261077	Missense_Mutation	novel	M497I	0.25
STAD	chr2	173221258	Intron	rs760551304		0.25
STAD	chr2	173209785	Silent	rs145549000	T267T	0.31
STAD	chr2	173209785	Silent	rs145549000	T267T	0.09
STAD	chr2	173239442	Missense_Mutation	novel	I435M	0.31
STAD	chr2	173239411	Missense_Mutation	NA	G425V	0.63
STAD	chr2	173169862	Missense_Mutation	NA	L73I	0.36
STAD	chr2	173198122	Intron	rs768159171		0.28
STAD	chr2	173266127	Missense_Mutation	NA	N594D	0.24
STAD	chr2	173266364	Missense_Mutation	NA	Y673N	0.09
STAD	chr2	173197992	Intron	novel		0.32
STAD	chr2	173217222	Frame_Shift_Del	novel	*K321Sfs2**	0.3
STAD	chr2	173217215	Missense_Mutation	novel	W318R	0.25
STAD	chr2	173187585	Missense_Mutation	NA	P126L	0.19
STAD	chr2	173182895	Missense_Mutation	rs746903757	N97Y	0.51
STAD	chr2	173266693	Silent	rs746871474	P782P	0.24
THCA	chr2	173091189	Frame_Shift_Ins	novel	*A54Rfs26**	0.11
THCA	chr2	173209939	Intron	novel		0.09
UCEC	chr2	173232194	Nonsense_Mutation	NA	Y345*	0.27
UCEC	chr2	173239421	Silent	NA	P428P	0.33
UCEC	chr2	173266477	Silent	novel	Y710Y	0.31
UCEC	chr2	173217169	Silent	NA	S302S	0.32
UCEC	chr2	173198079	Silent	novel	L212L	0.45
UCEC	chr2	173226765	Intron	novel		0.36
UCEC	chr2	173266201	Silent	novel	P618P	0.07
UCEC	chr2	173263848	Missense_Mutation	NA	T552I	0.52
UCEC	chr2	173210018	Intron	novel		0.41
UCEC	chr2	173217138	Missense_Mutation	NA	E292V	0.49
UCEC	chr2	173198177	Intron	novel		0.27
UCEC	chr2	173222259	Intron	novel		0.32
UCEC	chr2	173091126	Missense_Mutation	rs374943647	R32Q	0.39
UCEC	chr2	173263888	Silent	rs772234268	S565S	0.38
UCEC	chr2	173238406	Missense_Mutation	novel	N413H	0.22
UCEC	chr2	173258750	Missense_Mutation	novel	T471A	0.1
UCEC	chr2	173182875	Missense_Mutation	NA	L90P	0.22
UCEC	chr2	173187560	Missense_Mutation	NA	M118L	0.43
UCEC	chr2	173221163	Intron	NA		0.28
UCEC	chr2	173266639	Silent	rs770195520	S764S	0.32
UCEC	chr2	173198122	Intron	rs768159171		0.15
UCEC	chr2	173091150	Missense_Mutation	NA	K40R	0.44
UCEC	chr2	173221154	Intron	novel		0.07
UCEC	chr2	173209958	Intron	novel		0.2
UCEC	chr2	173266288	Missense_Mutation	novel	F647L	0.33
UCEC	chr2	173182880	Missense_Mutation	novel	D92Y	0.16
UCEC	chr2	173209848	Intron	rs191495404		0.42
UCEC	chr2	173198741	Intron	rs747536944		0.36
UCEC	chr2	173226457	Intron	novel		0.38
UCEC	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.29
UCEC	chr2	173221576	Intron	novel		0.26
UCEC	chr2	173226686	Intron	novel		0.14
UCEC	chr2	173226941	Intron	novel		0.08
UCEC	chr2	173226956	Intron	novel		0.13
UCEC	chr2	173198714	Intron	novel		0.22
UCEC	chr2	173209715	Intron	rs372444102		0.33
UCEC	chr2	173227118	Intron	novel		0.07
UCEC	chr2	173226818	Intron	novel		0.25
UCEC	chr2	173266196	Missense_Mutation	rs750517616	R617W	0.44
UCEC	chr2	173222205	Intron	novel		0.53
UCEC	chr2	173226860	Intron	novel		0.41
UCEC	chr2	173226520	Intron	novel		0.48
UCEC	chr2	173266127	Missense_Mutation	NA	N594D	0.06
UCEC	chr2	173266676	Missense_Mutation	novel	P777S	0.35
UCEC	chr2	173226761	Intron	novel		0.3
UCEC	chr2	173209670	Intron	novel		0.3
UCEC	chr2	173266572	Missense_Mutation	novel	T742I	0.29
UCEC	chr2	173266758	3'UTR	novel		0.14
UCEC	chr2	173221269	Intron	rs201188933		0.26
UCEC	chr2	173198773	Intron	novel		0.45
UCEC	chr2	173221343	Intron	novel		0.24
UCEC	chr2	173266288	Silent	rs772497418	F647F	0.4
UCEC	chr2	173222470	Intron	novel		0.17
UCEC	chr2	173258797	Missense_Mutation	novel	E486D	0.33
UCEC	chr2	173222534	Intron	novel		0.38
UCEC	chr2	173191173	Missense_Mutation	novel	G193D	0.43
UCEC	chr2	173198102	Frame_Shift_Del	NA	*N222Tfs4**	0.38
UCEC	chr2	173266440	Frame_Shift_Del	novel	*K699Vfs132**	0.08
UCEC	chr2	173226678	Intron	novel		0.11
UCEC	chr2	173187618	Missense_Mutation	NA	R137I	0.28
UCEC	chr2	173227007	Intron	novel		0.29
UCEC	chr2	173266116	Missense_Mutation	rs200257993	R590H	0.17
UCEC	chr2	173198212	Intron	novel		0.08
UCEC	chr2	173222369	Intron	novel		0.33
UCEC	chr2	173232195	Missense_Mutation	novel	C346S	0.46
UCEC	chr2	173221620	Intron	novel		1
UCEC	chr2	173221621	Intron	novel		1
UCEC	chr2	173091061	Missense_Mutation	NA	Q10H	0.42
UCEC	chr2	173198122	Intron	rs768159171		0.16
UCEC	chr2	173198029	Missense_Mutation	NA	L196I	0.19
UCEC	chr2	173221544	Intron	novel		0.17
UCEC	chr2	173197846	Intron	novel		0.52
UCEC	chr2	173266515	Missense_Mutation	novel	N723S	0.16
UCEC	chr2	173266638	Missense_Mutation	novel	S764N	0.43
UCEC	chr2	173222411	Intron	novel		0.37
UCEC	chr2	173217204	Missense_Mutation	NA	R314H	0.17
UCEC	chr2	173221491	Intron	rs371148135		0.27
UCEC	chr2	173266126	Silent	NA	S593S	0.26
UCEC	chr2	173091031	5'UTR	novel		0.23
UCEC	chr2	173182946	Missense_Mutation	novel	V114L	0.33
UCEC	chr2	173222183	Intron	novel		0.43
UCEC	chr2	173222554	Intron	novel		0.47
UCEC	chr2	173239449	Silent	rs780688121	L438L	0.33
UCS	chr2	173217204	Missense_Mutation	novel	R314L	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1153	0.012962
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
SARC	0.044	Kaplan-Meier Survival Analysis
MESO	0.00024	Kaplan-Meier Survival Analysis
ACC	0.005	Kaplan-Meier Survival Analysis
HNSC	0.035	Kaplan-Meier Survival Analysis
LUSC	0.04	Kaplan-Meier Survival Analysis
ESCA	0.029	Kaplan-Meier Survival Analysis
KIRP	0.00041	Kaplan-Meier Survival Analysis
COAD	0.0042	Kaplan-Meier Survival Analysis
BLCA	0.0028	Kaplan-Meier Survival Analysis
CESC	0.042	Kaplan-Meier Survival Analysis
LAML	0.039	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
LIHC	0.0039	Kaplan-Meier Survival Analysis
LUAD	0.038	Kaplan-Meier Survival Analysis
UVM	0.00064	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000091436 (Gene tree)
Gene ID: 51776
Gene Symbol: MAP3K20
Alias: MLTKalpha|MLTKbeta|ZAK|MLTK|MLK7|MRK
Full Name: mitogen-activated protein kinase kinase kinase 20
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 192,576 bases
Position: chr2:173,075,435-173,268,010
Accession: 17797
RBP type: non-canonical RBP
Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409176	MAP3K20-203	2572	XM_005246640	ENSP00000387259	800 (aa)	XP_005246697	Q9NYL2
ENST00000476618	MAP3K20-206	4010	-	-	- (aa)	-	-
ENST00000480606	MAP3K20-207	821	-	-	- (aa)	-	-
ENST00000375213	MAP3K20-202	3741	-	ENSP00000364361	800 (aa)	-	Q9NYL2
ENST00000468408	MAP3K20-205	585	-	-	- (aa)	-	-
ENST00000338983	MAP3K20-201	7179	XM_017004323	ENSP00000340257	455 (aa)	XP_016859812	Q9NYL2
ENST00000539448	MAP3K20-208	2312	XM_017004324	ENSP00000439414	455 (aa)	XP_016859813	Q9NYL2
ENST00000422149	MAP3K20-204	661	-	ENSP00000411923	138 (aa)	-	C9J3F7

Gene Model

Click here to download ENSG00000091436's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000091436	Hemoglobins	4.86540771444943E-5	17903294
ENSG00000091436	Hemoglobins	3.38333824896342E-5	17903294
ENSG00000091436	Stroke	4.1882393E-004	-
ENSG00000091436	Longevity	1E-6	27015805
ENSG00000091436	Adiponectin	2E-6	26299439

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000091436	rs722864	2	173118476	G	Lung cancer	28604730	[1.05-1.11]	1.0751604	EFO_0001071
ENSG00000091436	rs1866631	2	173211033	A	Lung cancer in ever smokers	28604730	[1.04-1.11]	1.0744331	EFO_0006527\|EFO_0001071
ENSG00000091436	rs4972539	2	173242571	?	Parental longevity (mother's age at death)	27015805	[0.018-0.043] unit decrease	0.03089	EFO_0007796
ENSG00000091436	rs10497399	2	173249411	?	Adiponectin levels	26299439			EFO_0004502
ENSG00000091436	rs10193498	2	173229617	A	Educational attainment (MTAG)	30038396	[0.0087-0.0145] unit increase	0.0116	EFO_0004784
ENSG00000091436	rs10193498	2	173229617	A	Highest math class taken	30038396	[0.012-0.023] unit increase	0.0175	EFO_0004875
ENSG00000091436	rs10193498	2	173229617	A	Self-reported math ability (MTAG)	30038396	[0.0094-0.0172] unit increase	0.0133	EFO_0004875
ENSG00000091436	rs10193498	2	173229617	A	Highest math class taken (MTAG)	30038396	[0.012-0.019] unit increase	0.0154	EFO_0004875
ENSG00000091436	rs10193498	2	173229617	A	Cognitive performance (MTAG)	30038396	[0.013-0.024] unit increase	0.0186	EFO_0008354
ENSG00000091436	rs10193498	2	173229617	A	Educational attainment (years of education)	30038396	[0.0066-0.0128] unit increase	0.0097	EFO_0004784
ENSG00000091436	rs7575189	2	173150440	A	Smoking status (ever vs never smokers)	30643258	[0.0071-0.0151] unit decrease	0.011123441	EFO_0004318
ENSG00000091436	rs13035366	2	173194654	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000091436	rs6758859	2	173100328	T	Diastolic blood pressure	30224653	[0.086-0.156] mmHg increase	0.1211	EFO_0006336
ENSG00000091436	rs6750801	2	173202452	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0048-0.0092] unit increase	0.00698417	EFO_0006527
ENSG00000091436	rs13004345	2	173172619	C	Chronotype	30696823		1.0190797	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000091436's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000091436	MAP3K20	100	99.275	ENSMUSG00000004085	Map3k20	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000077	DNA damage checkpoint	11836244.	IMP	Process
GO:0000186	activation of MAPKK activity	11836244.	TAS	Process
GO:0000287	magnesium ion binding	11836244.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004674	protein serine/threonine kinase activity	11836244.	IDA	Function
GO:0004709	MAP kinase kinase kinase activity	11836244.	IDA	Function
GO:0005515	protein binding	21988832.	IPI	Function
GO:0005524	ATP binding	11836244.	IDA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006468	protein phosphorylation	11836244.	IDA	Process
GO:0007010	cytoskeleton organization	-	IEA	Process
GO:0007050	cell cycle arrest	11836244.	IMP	Process
GO:0007093	mitotic cell cycle checkpoint	15342622.	IDA	Process
GO:0007257	activation of JUN kinase activity	11836244.	IDA	Process
GO:0008219	cell death	11836244.	NAS	Process
GO:0008283	cell proliferation	11836244.	NAS	Process
GO:0030154	cell differentiation	11836244.	NAS	Process
GO:0042733	embryonic digit morphogenesis	26755636.	IMP	Process
GO:0043065	positive regulation of apoptotic process	10924358.	IDA	Process
GO:0051403	stress-activated MAPK cascade	11836244.	IDA	Process
GO:0060173	limb development	26755636.	IMP	Process
GO:0071480	cellular response to gamma radiation	11836244.	IDA	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.