EuRBPDB

Ensembl ID

ENSG00000090097 (Gene tree)

Gene ID

57060

Gene Symbol

PCBP4

Alias

MCG10|LIP4

Full Name

poly(rC) binding protein 4

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Minus strand

Length

16,563 bases

Position

chr3:51,957,454-51,974,016

Accession

8652

Summary

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]