EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28799673TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.J Cell Biochem2018 FebYan Ldoi: 10.1002/jcb.26340
23444224Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.Clin Cancer Res2013 Apr 15Martens-de Kemp SRdoi: 10.1158/1078-0432.CCR-12-2539
24718984TPX2 regulates tumor growth in human cervical carcinoma cells.Mol Med Rep2014 JunJiang Pdoi: 10.3892/mmr.2014.2106
25914189Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer.Cancer Med2015 JulMiwa Tdoi: 10.1002/cam4.453
25239289TPX2 siRNA regulates growth and invasion of esophageal cancer cells.Biomed Pharmacother2014 SepLiu HCdoi: 10.1016/j.biopha.2014.08.008
16489064Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer.Clin Cancer Res2006 Feb 15Ma Y-
24625450RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer.PLoS One2014 Mar 13C??ceres-Gorriti KYdoi: 10.1371/journal.pone.0091000
22307108The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer.Oncol Rep2012 MayChang Hdoi: 10.3892/or.2012.1668
22761906High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer.PLoS One2012Vainio Pdoi: 10.1371/journal.pone.0039801
24341487TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer.J Transl Med2013 Dec 17Wei Pdoi: 10.1186/1479-5876-11-313.
24556998TPX2: of spindle assembly, DNA damage response, and cancer.Cell Mol Life Sci2014 AugNeumayer Gdoi: 10.1007/s00018-014-1582-7
28069036TPX2 expression is associated with poor survival in gastric cancer.World J Surg Oncol2017 Jan 9Tomii Cdoi: 10.1186/s12957-016-1095-y.
27314162Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer.Cancer Biol Ther2016 Aug 2Liang Bdoi: 10.1080/15384047.2016.1195046
30177840TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.Oncogene2019 Febvan Gijn SEdoi: 10.1038/s41388-018-0470-2

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2031801059SilentnovelF741F0.23
BLCAchr2031782369Missense_MutationnovelE392G0.06
BLCAchr2031777579Missense_MutationnovelQ275K0.39
BLCAchr2031798419Missense_MutationnovelR667K0.06
BLCAchr2031782302Missense_MutationnovelP370A0.49
BLCAchr2031770382Missense_MutationnovelQ132H0.32
BLCAchr2031777542SilentnovelF262F0.08
BLCAchr2031797515Missense_MutationNAE649K0.21
BLCAchr2031775963Missense_MutationnovelF235L0.1
BRCAchr20318011583'UTRnovel0.35
BRCAchr2031782270Missense_MutationNAS359F0.16
CESCchr2031797473Missense_MutationNAQ635E0.24
CESCchr2031766655Nonsense_MutationnovelS110*0.06
CESCchr2031782302Missense_MutationnovelP370A0.13
CESCchr2031797413Missense_MutationNAE615K0.17
COADchr2031783919Missense_MutationNAV471L0.26
COADchr2031801004Missense_MutationNAG723D0.19
COADchr2031766588Nonsense_MutationnovelE88*0.15
COADchr2031797502Missense_MutationnovelK644N0.05
COADchr2031766565Missense_MutationnovelT80I0.36
COADchr2031777570Missense_MutationnovelP272S0.28
COADchr2031757480Missense_MutationNAS2P0.04
COADchr20318011543'UTRnovel0.18
COADchr20318010983'UTRrs7761418430.15
COADchr20318011043'UTRrs3771249740.11
COADchr20318012503'UTRnovel0.5
COADchr2031793856Silentrs759746158D506D0.13
COADchr2031793947Missense_MutationnovelP537T0.31
COADchr2031770403Missense_MutationNAK139N0.21
COADchr2031794007Nonsense_MutationNAE557*0.17
COADchr2031777619Missense_Mutationrs746496077R288Q0.16
ESCAchr2031770367SilentnovelQ127Q0.18
ESCAchr2031792744Missense_MutationnovelE475Q0.38
ESCAchr2031794004Missense_MutationnovelK556Q0.14
GBMchr2031801050SilentnovelS738S0.07
GBMchr2031792756Missense_MutationnovelL479I0.14
GBMchr2031794014Missense_MutationnovelQ559L0.07
GBMchr2031794451Frame_Shift_DelnovelL579Pfs*120.03
GBMchr2031783913Missense_MutationNAD469Y0.29
GBMchr2031770380Missense_MutationnovelQ132K0.2
HNSCchr2031778973Missense_MutationnovelK348R0.13
HNSCchr20318011153'UTRnovel0.17
HNSCchr2031777619Missense_MutationnovelR288L0.35
HNSCchr20318011483'UTRnovel0.43
HNSCchr2031775979Missense_MutationnovelA241T0.5
HNSCchr2031775976Missense_MutationnovelL240V0.09
KIRCchr2031777595Missense_MutationNAE280A0.08
KIRCchr2031798392Frame_Shift_DelnovelE658Dfs*240.32
KIRCchr2031797491Missense_MutationnovelK641Q0.08
KIRPchr2031801076Missense_MutationNAC747F0.33
LAMLchr2031801050SilentnovelS738S0.06
LAMLchr2031782303Missense_MutationnovelP370L0.03
LGGchr2031757517Missense_Mutationrs781554900S14L0.06
LGGchr2031800969Splice_SiteNAX712_splice0.05
LGGchr2031777637Missense_MutationnovelP294H0.42
LGGchr2031783833Missense_MutationnovelQ442R0.07
LGGchr2031783730Missense_MutationnovelD408N0.07
LIHCchr2031793903Missense_MutationnovelP522L0.41
LIHCchr2031777511Missense_MutationNAS252I0.09
LIHCchr2031783851Missense_MutationnovelK448M0.36
LIHCchr2031777544Missense_MutationNAR263L0.44
LUADchr2031798388Nonsense_MutationNAQ657*0.15
LUADchr2031757554SilentNAG26G0.39
LUADchr2031778829Missense_MutationNAG300V0.11
LUADchr2031777610Missense_MutationnovelS285C0.18
LUADchr2031770422Missense_MutationnovelA146P0.27
LUADchr2031757529Missense_MutationnovelN18S0.04
LUADchr2031760108Missense_MutationNAG53V0.16
LUADchr2031777512Silentrs142446283S252S0.13
LUADchr2031778907Missense_MutationnovelP326H0.1
LUADchr2031766669Missense_MutationNAA115T0.25
LUADchr2031775892Nonsense_MutationnovelE212*0.11
LUADchr2031757524SilentNAF16F0.23
LUADchr2031782259SilentnovelP355P0.24
LUADchr2031794015Missense_MutationNAQ559H0.18
LUADchr2031771582Missense_MutationNAE170Q0.08
LUSCchr2031783780SilentnovelV424V0.13
LUSCchr2031777538Missense_MutationnovelH261L0.4
LUSCchr2031778939Nonsense_Mutationrs776728395R337*0.22
LUSCchr20318011573'UTRnovel0.27
OVchr2031792825In_Frame_InsnovelD502delinsGVVELKDCY0.04
OVchr20318011093'UTRnovel0.52
OVchr2031770438Missense_MutationNAI151T0.33
PAADchr2031783793Missense_Mutationrs747166089E429K0.21
PAADchr2031801022Missense_MutationnovelS729N0.17
PAADchr20318011953'UTRnovel0.24
PCPGchr2031778965Missense_MutationnovelR345S0.14
PRADchr2031775889Nonsense_MutationNAE211*0.32
READchr2031760124Missense_MutationnovelK58N0.39
READchr20318012113'UTRnovel0.38
SARCchr2031783827Missense_MutationnovelR440I0.13
SKCMchr2031783880Missense_MutationNAH458Y0.4
SKCMchr2031777628Missense_MutationNAP291L0.35
SKCMchr2031778940Missense_MutationNAR337Q0.31
SKCMchr2031783776Missense_MutationNAP423H0.26
SKCMchr2031777517Missense_MutationNAV254G0.06
SKCMchr2031783880Missense_MutationNAH458Y0.27
SKCMchr2031793919SilentNAI527I0.3
SKCMchr2031793954Missense_MutationNAS539L0.38
SKCMchr2031793965Nonsense_MutationNAR543*0.29
SKCMchr2031792807Nonsense_Mutationrs267605874R496*0.15
SKCMchr2031760129Missense_Mutationrs772705258P60L0.28
SKCMchr2031783898Missense_MutationnovelT464S0.33
SKCMchr2031783880Missense_MutationNAH458Y0.12
SKCMchr2031793919SilentNAI527I0.26
STADchr2031775870Missense_MutationNAQ204H0.11
STADchr2031793990In_Frame_DelnovelE552del0.34
STADchr2031782391Splice_SiteNAX399_splice0.39
STADchr20317574465'UTRnovel0.3
STADchr2031778869Missense_MutationNAK313N0.35
STADchr2031783849Missense_MutationNAK447N0.19
STADchr2031794011Missense_MutationNAL558P0.27
STADchr2031782325SilentnovelR377R0.31
STADchr2031782332Missense_MutationNAA380T0.22
STADchr2031771668Silentrs764868274C198C0.31
STADchr2031793856Silentrs759746158D506D0.2
STADchr2031782280Missense_MutationnovelK362N0.77
STADchr2031757497SilentNAS7S0.14
UCECchr2031783768Missense_MutationNAK420N0.31
UCECchr2031792807Nonsense_Mutationrs267605874R496*0.31
UCECchr2031801067Missense_Mutationrs753710645R744Q0.32
UCECchr2031766579Missense_MutationnovelA85T0.41
UCECchr2031775981SilentnovelA241A0.22
UCECchr2031782365Missense_MutationnovelA391T0.39
UCECchr2031793856Silentrs759746158D506D0.37
UCECchr2031792785SilentnovelA488A0.22
UCECchr2031794007Nonsense_MutationNAE557*0.41
UCECchr2031783802Missense_MutationNAG432S0.22
UCECchr2031798480SilentNAQ687Q0.47
UCECchr2031783814Missense_MutationNAE436K0.22
UCECchr2031792825Missense_MutationNAD502Y0.17
UCECchr2031775931Missense_MutationnovelV225M0.19
UCECchr2031793882Missense_MutationnovelP515H0.19
UCECchr2031760164Missense_MutationNAT72A0.34
UCECchr2031792807Nonsense_Mutationrs267605874R496*0.54
UCECchr2031792807Nonsense_Mutationrs267605874R496*0.22
UCECchr2031778883Missense_MutationnovelD318G0.36
UCECchr20317574315'UTRnovel0.54
UCECchr20318010983'UTRrs7761418430.48
UCECchr20318012033'UTRrs1448210150.6
UCECchr2031771683Splice_SitenovelX203_splice0.55
UCECchr2031775871Missense_MutationnovelK205Q0.33
UCECchr2031760151SilentnovelQ67Q0.44
UCECchr2031775966Missense_MutationnovelK236N0.19
UCECchr2031778874Missense_Mutationrs763738869R315I0.18
UCECchr2031797443Missense_MutationnovelF625L0.41
UCECchr2031798430Missense_MutationnovelR671W0.32
UCECchr2031793979SilentnovelR547R0.38
UCECchr2031797493Missense_MutationnovelK641N0.59
UCECchr2031771620Missense_MutationNAK182N0.3
UCECchr2031792807Nonsense_Mutationrs267605874R496*0.22
UCECchr2031794447Missense_MutationnovelN578D0.05
UCECchr2031775958Nonsense_MutationnovelE234*0.28
UCECchr2031757485Missense_MutationnovelQ3H0.22
UCECchr2031778980Frame_Shift_InsnovelI351Gfs*140.05
UCECchr2031778980Frame_Shift_InsnovelI351Gfs*140.09
UCECchr2031771624Missense_MutationnovelA184T0.3
UCECchr2031770440Missense_MutationnovelD152N0.72
UCECchr2031771584Missense_MutationnovelE170D0.49
UCECchr2031792752Missense_MutationnovelK477N0.16
UCECchr2031794533SilentnovelQ606Q0.17
UCECchr20318011713'UTRnovel0.13
UCECchr20318012923'UTRnovel0.18
UCECchr2031783793Missense_Mutationrs747166089E429K0.45
UCECchr2031771668Nonsense_MutationnovelC198*0.39
UCECchr2031792802Missense_MutationnovelR494I0.22
UCSchr2031766621Missense_MutationnovelA99S0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.52217.3224e-09
CESCAMP0.42374.2399e-10
COADAMP0.70731.1561e-39
LAMLAMP0.01570.18592
LUADAMP0.31590.19771
LUSCAMP0.46711.8626e-05
OVAMP0.53370.027181
READAMP0.86671.9519e-21
UCSAMP0.76794.3292e-10

Survival Analysis
CancerP-value Q-value
THYM0.0022

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.0027

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

SKCM0.0011

Kaplan-Meier Survival Analysis

KIRP0.00015

Kaplan-Meier Survival Analysis

PAAD0.00011

Kaplan-Meier Survival Analysis

PCPG0.036

Kaplan-Meier Survival Analysis

KICH0.015

Kaplan-Meier Survival Analysis

UCEC0.0001

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

CHOL0.043

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000088325 (Gene tree)
Gene ID
22974
Gene Symbol
TPX2
Alias
p100|DIL-2|C20orf2|C20orf1
Full Name
TPX2 microtubule nucleation factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
67,987 bases
Position
chr20:31,733,819-31,801,805
Accession
1249
RBP type
non-canonical RBP
Summary
(TPX2 Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gastric Cancer Network 1 and PLK1 signaling events. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17942399CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.J Biol Chem2007 Dec 28Minshall N-
1670777Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos.J Cell Biol1991 JanMurray MT-
26624896Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization.PLoS One2015 Dec 1Zhang Hdoi: 10.1371/journal.pone.0142868
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000340513TPX2-2023605-ENSP00000341145783 (aa)-Q9ULW0
ENST00000300403TPX2-2013497XM_011528697ENSP00000300403747 (aa)XP_011526999Q9ULW0
Gene Model
Click here to download ENSG00000088325's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000088325Affective Disorders, Psychotic3E-626184070
ENSG00000088325Attention Deficit Disorder with Hyperactivity3E-626184070
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000088325's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000088325TPX29978.800ENSMUSG00000027469Tpx210078.667Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000278mitotic cell cycle9207457.TASProcess
GO:0000922spindle pole14718566.IDAComponent
GO:0005515protein binding14580337.17474147.19357306.20360068.21242313.22110403.25986610.27837025.IPIFunction
GO:0005524ATP binding10512675.TASFunction
GO:0005525GTP binding10512675.TASFunction
GO:0005634nucleus9207457.TASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005815microtubule organizing center-IDAComponent
GO:0005819spindle18663142.ISSComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule-IEAComponent
GO:0006915apoptotic process-IEAProcess
GO:0008283cell proliferation10512675.TASProcess
GO:0010389regulation of G2/M transition of mitotic cell cycle-TASProcess
GO:0015630microtubule cytoskeleton-IDAComponent
GO:0019901protein kinase binding14580337.18662907.19801554.IPIFunction
GO:0032147activation of protein kinase activity14580337.19801554.IDAProcess
GO:0043203axon hillock-IEAComponent
GO:0045171intercellular bridge-IDAComponent
GO:0051301cell division-IEAProcess
GO:0060236regulation of mitotic spindle organization18663142.ISSProcess
GO:0061676importin-alpha family protein binding26165940.IDAFunction
GO:0072686mitotic spindle-IDAComponent
GO:0090307mitotic spindle assembly26165940.IDAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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