EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28799673	TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.	J Cell Biochem	2018 Feb	Yan L	doi: 10.1002/jcb.26340
23444224	Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.	Clin Cancer Res	2013 Apr 15	Martens-de Kemp SR	doi: 10.1158/1078-0432.CCR-12-2539
24718984	TPX2 regulates tumor growth in human cervical carcinoma cells.	Mol Med Rep	2014 Jun	Jiang P	doi: 10.3892/mmr.2014.2106
25914189	Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer.	Cancer Med	2015 Jul	Miwa T	doi: 10.1002/cam4.453
25239289	TPX2 siRNA regulates growth and invasion of esophageal cancer cells.	Biomed Pharmacother	2014 Sep	Liu HC	doi: 10.1016/j.biopha.2014.08.008
16489064	Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer.	Clin Cancer Res	2006 Feb 15	Ma Y	-
24625450	RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer.	PLoS One	2014 Mar 13	C??ceres-Gorriti KY	doi: 10.1371/journal.pone.0091000
22307108	The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer.	Oncol Rep	2012 May	Chang H	doi: 10.3892/or.2012.1668
22761906	High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer.	PLoS One	2012	Vainio P	doi: 10.1371/journal.pone.0039801
24341487	TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer.	J Transl Med	2013 Dec 17	Wei P	doi: 10.1186/1479-5876-11-313.
24556998	TPX2: of spindle assembly, DNA damage response, and cancer.	Cell Mol Life Sci	2014 Aug	Neumayer G	doi: 10.1007/s00018-014-1582-7
28069036	TPX2 expression is associated with poor survival in gastric cancer.	World J Surg Oncol	2017 Jan 9	Tomii C	doi: 10.1186/s12957-016-1095-y.
27314162	Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer.	Cancer Biol Ther	2016 Aug 2	Liang B	doi: 10.1080/15384047.2016.1195046
30177840	TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.	Oncogene	2019 Feb	van Gijn SE	doi: 10.1038/s41388-018-0470-2

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr20	31801059	Silent	novel	F741F	0.23
BLCA	chr20	31782369	Missense_Mutation	novel	E392G	0.06
BLCA	chr20	31777579	Missense_Mutation	novel	Q275K	0.39
BLCA	chr20	31798419	Missense_Mutation	novel	R667K	0.06
BLCA	chr20	31782302	Missense_Mutation	novel	P370A	0.49
BLCA	chr20	31770382	Missense_Mutation	novel	Q132H	0.32
BLCA	chr20	31777542	Silent	novel	F262F	0.08
BLCA	chr20	31797515	Missense_Mutation	NA	E649K	0.21
BLCA	chr20	31775963	Missense_Mutation	novel	F235L	0.1
BRCA	chr20	31801158	3'UTR	novel		0.35
BRCA	chr20	31782270	Missense_Mutation	NA	S359F	0.16
CESC	chr20	31797473	Missense_Mutation	NA	Q635E	0.24
CESC	chr20	31766655	Nonsense_Mutation	novel	S110*	0.06
CESC	chr20	31782302	Missense_Mutation	novel	P370A	0.13
CESC	chr20	31797413	Missense_Mutation	NA	E615K	0.17
COAD	chr20	31783919	Missense_Mutation	NA	V471L	0.26
COAD	chr20	31801004	Missense_Mutation	NA	G723D	0.19
COAD	chr20	31766588	Nonsense_Mutation	novel	E88*	0.15
COAD	chr20	31797502	Missense_Mutation	novel	K644N	0.05
COAD	chr20	31766565	Missense_Mutation	novel	T80I	0.36
COAD	chr20	31777570	Missense_Mutation	novel	P272S	0.28
COAD	chr20	31757480	Missense_Mutation	NA	S2P	0.04
COAD	chr20	31801154	3'UTR	novel		0.18
COAD	chr20	31801098	3'UTR	rs776141843		0.15
COAD	chr20	31801104	3'UTR	rs377124974		0.11
COAD	chr20	31801250	3'UTR	novel		0.5
COAD	chr20	31793856	Silent	rs759746158	D506D	0.13
COAD	chr20	31793947	Missense_Mutation	novel	P537T	0.31
COAD	chr20	31770403	Missense_Mutation	NA	K139N	0.21
COAD	chr20	31794007	Nonsense_Mutation	NA	E557*	0.17
COAD	chr20	31777619	Missense_Mutation	rs746496077	R288Q	0.16
ESCA	chr20	31770367	Silent	novel	Q127Q	0.18
ESCA	chr20	31792744	Missense_Mutation	novel	E475Q	0.38
ESCA	chr20	31794004	Missense_Mutation	novel	K556Q	0.14
GBM	chr20	31801050	Silent	novel	S738S	0.07
GBM	chr20	31792756	Missense_Mutation	novel	L479I	0.14
GBM	chr20	31794014	Missense_Mutation	novel	Q559L	0.07
GBM	chr20	31794451	Frame_Shift_Del	novel	*L579Pfs12**	0.03
GBM	chr20	31783913	Missense_Mutation	NA	D469Y	0.29
GBM	chr20	31770380	Missense_Mutation	novel	Q132K	0.2
HNSC	chr20	31778973	Missense_Mutation	novel	K348R	0.13
HNSC	chr20	31801115	3'UTR	novel		0.17
HNSC	chr20	31777619	Missense_Mutation	novel	R288L	0.35
HNSC	chr20	31801148	3'UTR	novel		0.43
HNSC	chr20	31775979	Missense_Mutation	novel	A241T	0.5
HNSC	chr20	31775976	Missense_Mutation	novel	L240V	0.09
KIRC	chr20	31777595	Missense_Mutation	NA	E280A	0.08
KIRC	chr20	31798392	Frame_Shift_Del	novel	*E658Dfs24**	0.32
KIRC	chr20	31797491	Missense_Mutation	novel	K641Q	0.08
KIRP	chr20	31801076	Missense_Mutation	NA	C747F	0.33
LAML	chr20	31801050	Silent	novel	S738S	0.06
LAML	chr20	31782303	Missense_Mutation	novel	P370L	0.03
LGG	chr20	31757517	Missense_Mutation	rs781554900	S14L	0.06
LGG	chr20	31800969	Splice_Site	NA	X712_splice	0.05
LGG	chr20	31777637	Missense_Mutation	novel	P294H	0.42
LGG	chr20	31783833	Missense_Mutation	novel	Q442R	0.07
LGG	chr20	31783730	Missense_Mutation	novel	D408N	0.07
LIHC	chr20	31793903	Missense_Mutation	novel	P522L	0.41
LIHC	chr20	31777511	Missense_Mutation	NA	S252I	0.09
LIHC	chr20	31783851	Missense_Mutation	novel	K448M	0.36
LIHC	chr20	31777544	Missense_Mutation	NA	R263L	0.44
LUAD	chr20	31798388	Nonsense_Mutation	NA	Q657*	0.15
LUAD	chr20	31757554	Silent	NA	G26G	0.39
LUAD	chr20	31778829	Missense_Mutation	NA	G300V	0.11
LUAD	chr20	31777610	Missense_Mutation	novel	S285C	0.18
LUAD	chr20	31770422	Missense_Mutation	novel	A146P	0.27
LUAD	chr20	31757529	Missense_Mutation	novel	N18S	0.04
LUAD	chr20	31760108	Missense_Mutation	NA	G53V	0.16
LUAD	chr20	31777512	Silent	rs142446283	S252S	0.13
LUAD	chr20	31778907	Missense_Mutation	novel	P326H	0.1
LUAD	chr20	31766669	Missense_Mutation	NA	A115T	0.25
LUAD	chr20	31775892	Nonsense_Mutation	novel	E212*	0.11
LUAD	chr20	31757524	Silent	NA	F16F	0.23
LUAD	chr20	31782259	Silent	novel	P355P	0.24
LUAD	chr20	31794015	Missense_Mutation	NA	Q559H	0.18
LUAD	chr20	31771582	Missense_Mutation	NA	E170Q	0.08
LUSC	chr20	31783780	Silent	novel	V424V	0.13
LUSC	chr20	31777538	Missense_Mutation	novel	H261L	0.4
LUSC	chr20	31778939	Nonsense_Mutation	rs776728395	R337*	0.22
LUSC	chr20	31801157	3'UTR	novel		0.27
OV	chr20	31792825	In_Frame_Ins	novel	D502delinsGVVELKDCY	0.04
OV	chr20	31801109	3'UTR	novel		0.52
OV	chr20	31770438	Missense_Mutation	NA	I151T	0.33
PAAD	chr20	31783793	Missense_Mutation	rs747166089	E429K	0.21
PAAD	chr20	31801022	Missense_Mutation	novel	S729N	0.17
PAAD	chr20	31801195	3'UTR	novel		0.24
PCPG	chr20	31778965	Missense_Mutation	novel	R345S	0.14
PRAD	chr20	31775889	Nonsense_Mutation	NA	E211*	0.32
READ	chr20	31760124	Missense_Mutation	novel	K58N	0.39
READ	chr20	31801211	3'UTR	novel		0.38
SARC	chr20	31783827	Missense_Mutation	novel	R440I	0.13
SKCM	chr20	31783880	Missense_Mutation	NA	H458Y	0.4
SKCM	chr20	31777628	Missense_Mutation	NA	P291L	0.35
SKCM	chr20	31778940	Missense_Mutation	NA	R337Q	0.31
SKCM	chr20	31783776	Missense_Mutation	NA	P423H	0.26
SKCM	chr20	31777517	Missense_Mutation	NA	V254G	0.06
SKCM	chr20	31783880	Missense_Mutation	NA	H458Y	0.27
SKCM	chr20	31793919	Silent	NA	I527I	0.3
SKCM	chr20	31793954	Missense_Mutation	NA	S539L	0.38
SKCM	chr20	31793965	Nonsense_Mutation	NA	R543*	0.29
SKCM	chr20	31792807	Nonsense_Mutation	rs267605874	R496*	0.15
SKCM	chr20	31760129	Missense_Mutation	rs772705258	P60L	0.28
SKCM	chr20	31783898	Missense_Mutation	novel	T464S	0.33
SKCM	chr20	31783880	Missense_Mutation	NA	H458Y	0.12
SKCM	chr20	31793919	Silent	NA	I527I	0.26
STAD	chr20	31775870	Missense_Mutation	NA	Q204H	0.11
STAD	chr20	31793990	In_Frame_Del	novel	E552del	0.34
STAD	chr20	31782391	Splice_Site	NA	X399_splice	0.39
STAD	chr20	31757446	5'UTR	novel		0.3
STAD	chr20	31778869	Missense_Mutation	NA	K313N	0.35
STAD	chr20	31783849	Missense_Mutation	NA	K447N	0.19
STAD	chr20	31794011	Missense_Mutation	NA	L558P	0.27
STAD	chr20	31782325	Silent	novel	R377R	0.31
STAD	chr20	31782332	Missense_Mutation	NA	A380T	0.22
STAD	chr20	31771668	Silent	rs764868274	C198C	0.31
STAD	chr20	31793856	Silent	rs759746158	D506D	0.2
STAD	chr20	31782280	Missense_Mutation	novel	K362N	0.77
STAD	chr20	31757497	Silent	NA	S7S	0.14
UCEC	chr20	31783768	Missense_Mutation	NA	K420N	0.31
UCEC	chr20	31792807	Nonsense_Mutation	rs267605874	R496*	0.31
UCEC	chr20	31801067	Missense_Mutation	rs753710645	R744Q	0.32
UCEC	chr20	31766579	Missense_Mutation	novel	A85T	0.41
UCEC	chr20	31775981	Silent	novel	A241A	0.22
UCEC	chr20	31782365	Missense_Mutation	novel	A391T	0.39
UCEC	chr20	31793856	Silent	rs759746158	D506D	0.37
UCEC	chr20	31792785	Silent	novel	A488A	0.22
UCEC	chr20	31794007	Nonsense_Mutation	NA	E557*	0.41
UCEC	chr20	31783802	Missense_Mutation	NA	G432S	0.22
UCEC	chr20	31798480	Silent	NA	Q687Q	0.47
UCEC	chr20	31783814	Missense_Mutation	NA	E436K	0.22
UCEC	chr20	31792825	Missense_Mutation	NA	D502Y	0.17
UCEC	chr20	31775931	Missense_Mutation	novel	V225M	0.19
UCEC	chr20	31793882	Missense_Mutation	novel	P515H	0.19
UCEC	chr20	31760164	Missense_Mutation	NA	T72A	0.34
UCEC	chr20	31792807	Nonsense_Mutation	rs267605874	R496*	0.54
UCEC	chr20	31792807	Nonsense_Mutation	rs267605874	R496*	0.22
UCEC	chr20	31778883	Missense_Mutation	novel	D318G	0.36
UCEC	chr20	31757431	5'UTR	novel		0.54
UCEC	chr20	31801098	3'UTR	rs776141843		0.48
UCEC	chr20	31801203	3'UTR	rs144821015		0.6
UCEC	chr20	31771683	Splice_Site	novel	X203_splice	0.55
UCEC	chr20	31775871	Missense_Mutation	novel	K205Q	0.33
UCEC	chr20	31760151	Silent	novel	Q67Q	0.44
UCEC	chr20	31775966	Missense_Mutation	novel	K236N	0.19
UCEC	chr20	31778874	Missense_Mutation	rs763738869	R315I	0.18
UCEC	chr20	31797443	Missense_Mutation	novel	F625L	0.41
UCEC	chr20	31798430	Missense_Mutation	novel	R671W	0.32
UCEC	chr20	31793979	Silent	novel	R547R	0.38
UCEC	chr20	31797493	Missense_Mutation	novel	K641N	0.59
UCEC	chr20	31771620	Missense_Mutation	NA	K182N	0.3
UCEC	chr20	31792807	Nonsense_Mutation	rs267605874	R496*	0.22
UCEC	chr20	31794447	Missense_Mutation	novel	N578D	0.05
UCEC	chr20	31775958	Nonsense_Mutation	novel	E234*	0.28
UCEC	chr20	31757485	Missense_Mutation	novel	Q3H	0.22
UCEC	chr20	31778980	Frame_Shift_Ins	novel	*I351Gfs14**	0.05
UCEC	chr20	31778980	Frame_Shift_Ins	novel	*I351Gfs14**	0.09
UCEC	chr20	31771624	Missense_Mutation	novel	A184T	0.3
UCEC	chr20	31770440	Missense_Mutation	novel	D152N	0.72
UCEC	chr20	31771584	Missense_Mutation	novel	E170D	0.49
UCEC	chr20	31792752	Missense_Mutation	novel	K477N	0.16
UCEC	chr20	31794533	Silent	novel	Q606Q	0.17
UCEC	chr20	31801171	3'UTR	novel		0.13
UCEC	chr20	31801292	3'UTR	novel		0.18
UCEC	chr20	31783793	Missense_Mutation	rs747166089	E429K	0.45
UCEC	chr20	31771668	Nonsense_Mutation	novel	C198*	0.39
UCEC	chr20	31792802	Missense_Mutation	novel	R494I	0.22
UCS	chr20	31766621	Missense_Mutation	novel	A99S	0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.5221	7.3224e-09
CESC	AMP	0.4237	4.2399e-10
COAD	AMP	0.7073	1.1561e-39
LAML	AMP	0.0157	0.18592
LUAD	AMP	0.3159	0.19771
LUSC	AMP	0.4671	1.8626e-05
OV	AMP	0.5337	0.027181
READ	AMP	0.8667	1.9519e-21
UCS	AMP	0.7679	4.3292e-10

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0022	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0027	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.0011	Kaplan-Meier Survival Analysis
KIRP	0.00015	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
PCPG	0.036	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000088325 (Gene tree)
Gene ID: 22974
Gene Symbol: TPX2
Alias: p100|DIL-2|C20orf2|C20orf1
Full Name: TPX2 microtubule nucleation factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 67,987 bases
Position: chr20:31,733,819-31,801,805
Accession: 1249
RBP type: non-canonical RBP
Summary: (TPX2 Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gastric Cancer Network 1 and PLK1 signaling events. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17942399	CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.	J Biol Chem	2007 Dec 28	Minshall N	-
1670777	Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos.	J Cell Biol	1991 Jan	Murray MT	-
26624896	Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization.	PLoS One	2015 Dec 1	Zhang H	doi: 10.1371/journal.pone.0142868

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340513	TPX2-202	3605	-	ENSP00000341145	783 (aa)	-	Q9ULW0
ENST00000300403	TPX2-201	3497	XM_011528697	ENSP00000300403	747 (aa)	XP_011526999	Q9ULW0

Gene Model

Click here to download ENSG00000088325's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000088325	Affective Disorders, Psychotic	3E-6	26184070
ENSG00000088325	Attention Deficit Disorder with Hyperactivity	3E-6	26184070

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000088325's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000088325	TPX2	99	78.800	ENSMUSG00000027469	Tpx2	100	78.667	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	9207457.	TAS	Process
GO:0000922	spindle pole	14718566.	IDA	Component
GO:0005515	protein binding	14580337.17474147.19357306.20360068.21242313.22110403.25986610.27837025.	IPI	Function
GO:0005524	ATP binding	10512675.	TAS	Function
GO:0005525	GTP binding	10512675.	TAS	Function
GO:0005634	nucleus	9207457.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005819	spindle	18663142.	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0008283	cell proliferation	10512675.	TAS	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0019901	protein kinase binding	14580337.18662907.19801554.	IPI	Function
GO:0032147	activation of protein kinase activity	14580337.19801554.	IDA	Process
GO:0043203	axon hillock	-	IEA	Component
GO:0045171	intercellular bridge	-	IDA	Component
GO:0051301	cell division	-	IEA	Process
GO:0060236	regulation of mitotic spindle organization	18663142.	ISS	Process
GO:0061676	importin-alpha family protein binding	26165940.	IDA	Function
GO:0072686	mitotic spindle	-	IDA	Component
GO:0090307	mitotic spindle assembly	26165940.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.