EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23702379	Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.	Pathol Res Pract	2013 Jun	Noh SJ	doi: 10.1016/j.prp.2013.03.011
19207554	Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma.	Dis Esophagus	2009	Hsu KF	doi: 10.1111/j.1442-2050.2008.00921.x
19242064	Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters.	Dis Markers	2009	Lee YY	doi: 10.3233/DMA-2009-0598.
24970760	Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells.	Carcinogenesis	2014 Nov	Lin CW	doi: 10.1093/carcin/bgu139
24265417	G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.	Arterioscler Thromb Vasc Biol	2014 Feb	Majumder S	doi: 10.1161/ATVBAHA.113.302689
19898426	Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression.	Mod Pathol	2010 Feb	Xu XZ	doi: 10.1038/modpathol.2009.157
23030700	The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.	APMIS	2013 Mar	Tsai WC	doi: 10.1111/j.1600-0463.2012.02952.x
23161539	The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.	J Biol Chem	2013 Jan 11	Shimamura S	doi: 10.1074/jbc.M112.386722
25212831	Vascular endothelial growth factor-C upregulates cortactin and promotes metastasis of esophageal squamous cell carcinoma.	Ann Surg Oncol	2014 Dec	Su CM	doi: 10.1245/s10434-014-4009-7
17178864	Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.	Cancer Res	2006 Dec 15	Luo ML	-
17292556	Roles of cortactin in tumor pathogenesis.	Biochim Biophys Acta	2007 Jun	Buday L	-
30562756	ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.	Cell Physiol Biochem	2018	Lang L	doi: 10.1159/000496048
26151562	Cortactin promotes colon cancer progression by regulating ERK pathway.	Int J Oncol	2015 Sep	Ni QF	doi: 10.3892/ijo.2015.3072
19885549	Localization of cortactin is associated with colorectal cancer development.	Int J Oncol	2009 Dec	Hirakawa H	-
24549769	Extravasation during bladder cancer metastasis requires cortactinmediated invadopodia formation.	Mol Med Rep	2014 Apr	Tokui N	doi: 10.3892/mmr.2014.1965
16261345	Dominant expression of 85-kDa form of cortactin in colorectal cancer.	J Cancer Res Clin Oncol	2006 Feb	Zhang LH	-
21858086	GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.	PLoS One	2011	Hashimoto A	doi: 10.1371/journal.pone.0023359
16442522	Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.	Exp Cell Res	2006 May 1	Bowden ET	-
17510372	Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters.	J Histochem Cytochem	2007 Sep	Tsai WC	-
16636290	Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.	Proc Natl Acad Sci U S A	2006 May 2	Hashimoto S	-
22377015	Cortactin and focal adhesion kinase as predictors of cancer risk in patients with premalignant oral epithelial lesions.	Oral Oncol	2012 Jul	de Vicente JC	doi: 10.1016/j.oraloncology.2012.02.004
21503569	microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein.	Int J Mol Med	2011 Sep	Zhang L	doi: 10.3892/ijmm.2011.679
26112958	Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma.	Int J Exp Pathol	2015 Aug	Hou H	doi: 10.1111/iep.12132
22050448	Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.	Int J Urol	2012 Jan	Nakane K	doi: 10.1111/j.1442-2042.2011.02888.x
16652145	Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells.	Oncogene	2006 Oct 5	Hill A	-
21418910	[A pivotal role of cortactin, a CTTN encoding protein, in endocytosis of human colon cancer].	Zhonghua Yi Xue Za Zhi	2011 Feb 15	Zhu JW	-
26952924	miR-542-3p inhibits the growth and invasion of colorectal cancer cells through targeted regulation of cortactin.	Int J Mol Med	2016 Apr	Long HC	doi: 10.3892/ijmm.2016.2505
21257711	An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.	Cancer Res	2011 Mar 1	Mader CC	doi: 10.1158/0008-5472.CAN-10-1432
24867096	FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.	Tumour Biol	2014 Sep	Cen G	doi: 10.1007/s13277-014-2104-9
22089141	HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin.	Oncol Rep	2012 Mar	Zuo Q	doi: 10.3892/or.2011.1553
22944623	Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.	J Clin Pathol	2012 Dec	Hou H	doi: 10.1136/jclinpath-2012-200940
18406052	Cortactin in tumor invasiveness.	Cancer Lett	2008 Jul 8	Weaver AM	doi: 10.1016/j.canlet.2008.02.066
21258212	Cortactin: a multifunctional regulator of cellular invasiveness.	Cell Adh Migr	2011 Mar-Apr	Kirkbride KC	-
21646305	Cortactin and focal adhesion kinase as predictors of cancer risk in patients with laryngeal premalignancy.	Cancer Prev Res (Phila)	2011 Aug	Rodrigo JP	doi: 10.1158/1940-6207.CAPR-10-0338
24465712	pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).	PLoS One	2014 Jan 22	Radhakrishnan VM	doi: 10.1371/journal.pone.0085796
27572123	Actin bundling by dynamin2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.	Int J Oncol	2016 Sep	Yamada H	doi: 10.3892/ijo.2016.3592
28404950	High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin.	Oncotarget	2017 May 30	Wang ZN	doi: 10.18632/oncotarget.15873.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	70435129	Silent	novel	L540L	0.13
BLCA	chr11	70435078	Missense_Mutation	novel	E523D	0.23
BLCA	chr11	70433155	Missense_Mutation	novel	E441K	0.08
BLCA	chr11	70420399	Splice_Site	novel	X227_splice	0.11
BLCA	chr11	70435123	Silent	rs545888686	Y538Y	0.35
BLCA	chr11	70421541	Missense_Mutation	novel	D288N	0.06
BLCA	chr11	70409843	Silent	novel	L58L	0.26
BLCA	chr11	70431226	Silent	NA	V404V	0.47
BLCA	chr11	70422986	Silent	NA	R316R	0.32
BLCA	chr11	70433183	Missense_Mutation	novel	A450G	0.3
BLCA	chr11	70422908	Intron	novel		0.63
BLCA	chr11	70435037	Missense_Mutation	NA	E510K	0.22
BLCA	chr11	70419823	Missense_Mutation	rs769315862	Q216E	0.79
BLCA	chr11	70435055	Missense_Mutation	novel	D516N	0.06
BLCA	chr11	70417121	Missense_Mutation	novel	R189K	0.39
BRCA	chr11	70436217	3'UTR	novel		0.19
BRCA	chr11	70435190	3'UTR	novel		0.43
BRCA	chr11	70433686	Missense_Mutation	NA	I495S	0.29
CESC	chr11	70436176	3'UTR	novel		0.3
CESC	chr11	70433697	Missense_Mutation	rs774668913	A499T	0.3
CESC	chr11	70436148	3'UTR	novel		0.21
CESC	chr11	70419807	Silent	novel	A210A	0.42
CESC	chr11	70435619	3'UTR	novel		0.33
CESC	chr11	70407353	Missense_Mutation	novel	A19V	0.23
CESC	chr11	70419843	Silent	rs567805186	H222H	0.38
CESC	chr11	70431216	Missense_Mutation	rs532238783	T401M	0.37
CESC	chr11	70433184	Silent	novel	A450A	0.46
CESC	chr11	70435100	Missense_Mutation	rs200712952	R531C	0.4
CESC	chr11	70433661	Missense_Mutation	rs144726386	D487N	0.23
CESC	chr11	70429075	Missense_Mutation	NA	R351T	0.13
CESC	chr11	70436440	3'UTR	novel		0.69
COAD	chr11	70422746	Intron	novel		0.16
COAD	chr11	70422884	Intron	novel		0.21
COAD	chr11	70414551	Missense_Mutation	rs777502801	G101S	0.15
COAD	chr11	70417101	Silent	rs542706268	T182T	0.39
COAD	chr11	70431217	Silent	NA	T401T	0.25
COAD	chr11	70414609	Missense_Mutation	NA	G120V	0.23
COAD	chr11	70435102	Silent	rs200713620	R531R	0.35
COAD	chr11	70435090	Silent	rs772572367	D527D	0.27
COAD	chr11	70414647	Missense_Mutation	NA	D133Y	0.24
COAD	chr11	70414568	Silent	NA	S106S	0.21
COAD	chr11	70407345	Silent	NA	D16D	0.4
ESCA	chr11	70435031	Missense_Mutation	rs369658947	D508N	0.11
GBM	chr11	70420432	Missense_Mutation	rs567039880	V238M	0.27
GBM	chr11	70431215	Missense_Mutation	novel	T401A	0.15
GBM	chr11	70435790	3'UTR	novel		0.2
GBM	chr11	70431229	Silent	rs747575729	S405S	0.19
GBM	chr11	70429163	Missense_Mutation	novel	E380D	0.64
GBM	chr11	70433677	Missense_Mutation	novel	D492V	0.2
HNSC	chr11	70414550	Silent	rs574999868	V100V	0.16
HNSC	chr11	70436291	3'UTR	novel		0.83
HNSC	chr11	70417040	Missense_Mutation	NA	Y162C	0.22
HNSC	chr11	70435155	Missense_Mutation	rs778284858	R549Q	0.23
HNSC	chr11	70435103	Missense_Mutation	novel	G532W	0.08
HNSC	chr11	70425374	Frame_Shift_Del	novel	*Q335Lfs5**	0.12
HNSC	chr11	70419780	Silent	NA	I201I	0.04
HNSC	chr11	70407530	Missense_Mutation	novel	E34K	0.21
HNSC	chr11	70419767	Missense_Mutation	NA	G197D	0.07
HNSC	chr11	70435631	3'UTR	novel		0.03
HNSC	chr11	70435767	3'UTR	rs779795316		0.06
HNSC	chr11	70435104	Missense_Mutation	novel	G532V	0.21
HNSC	chr11	70425331	Splice_Site	NA	X320_splice	0.26
HNSC	chr11	70417086	Missense_Mutation	novel	D177E	0.09
KIRP	chr11	70436415	3'UTR	novel		0.41
LGG	chr11	70429199	Splice_Region	novel	E392E	0.15
LGG	chr11	70429166	Silent	rs762293997	R381R	0.15
LGG	chr11	70415697	Missense_Mutation	NA	E146G	0.37
LIHC	chr11	70414617	Missense_Mutation	NA	G123S	0.34
LIHC	chr11	70422957	Missense_Mutation	NA	G307S	0.4
LIHC	chr11	70435185	3'UTR	novel		0.17
LUAD	chr11	70422918	Intron	novel		0.16
LUAD	chr11	70436303	3'UTR	novel		0.26
LUAD	chr11	70433154	Silent	rs202171066	T440T	0.15
LUAD	chr11	70433193	Silent	NA	Y453Y	0.18
LUAD	chr11	70407517	Splice_Site	NA	X30_splice	0.18
LUAD	chr11	70431188	Splice_Region	novel		0.21
LUAD	chr11	70435160	Nonstop_Mutation	novel	551Eext76	0.19
LUAD	chr11	70433134	Nonsense_Mutation	novel	R434*	0.06
LUAD	chr11	70431218	Frame_Shift_Del	novel	*P403Lfs29**	0.26
LUAD	chr11	70417068	Missense_Mutation	NA	K171N	0.32
LUAD	chr11	70433676	Missense_Mutation	NA	D492Y	0.17
LUAD	chr11	70433221	Missense_Mutation	NA	A463P	0.26
LUAD	chr11	70435691	3'UTR	novel		0.23
LUSC	chr11	70435181	3'UTR	novel		0.31
LUSC	chr11	70421475	Nonsense_Mutation	novel	K266*	0.25
LUSC	chr11	70435091	Missense_Mutation	NA	G528R	0.26
LUSC	chr11	70417019	Missense_Mutation	novel	S155F	0.34
LUSC	chr11	70414557	Missense_Mutation	novel	E103Q	0.48
LUSC	chr11	70414561	Missense_Mutation	NA	Y104C	0.27
LUSC	chr11	70420421	Missense_Mutation	NA	G234E	0.19
OV	chr11	70433647	Missense_Mutation	novel	E482A	0.15
OV	chr11	70435054	Silent	novel	P515P	0.12
OV	chr11	70422970	Missense_Mutation	NA	G311A	0.4
OV	chr11	70436472	3'UTR	novel		0.1
OV	chr11	70436473	3'UTR	novel		0.1
PAAD	chr11	70422807	Intron	novel		0.19
PAAD	chr11	70435119	Missense_Mutation	rs769689288	R537Q	0.03
PCPG	chr11	70435221	3'UTR	novel		0.5
PRAD	chr11	70422831	Intron	novel		0.44
PRAD	chr11	70419842	Missense_Mutation	novel	H222R	0.39
PRAD	chr11	70422929	Intron	novel		0.23
READ	chr11	70407345	Silent	NA	D16D	0.5
READ	chr11	70431217	Silent	NA	T401T	0.28
READ	chr11	70420456	Frame_Shift_Del	novel	*C246Pfs13**	0.64
READ	chr11	70419762	Silent	rs760754072	F195F	0.47
READ	chr11	70433668	Missense_Mutation	novel	Y489C	0.41
READ	chr11	70433669	Silent	rs138763797	Y489Y	0.46
SARC	chr11	70435717	3'UTR	novel		0.38
SARC	chr11	70422964	Missense_Mutation	novel	K309R	0.45
SARC	chr11	70409859	Nonsense_Mutation	novel	Q64*	0.16
SARC	chr11	70419848	Frame_Shift_Del	novel	*Q225Rfs5**	0.32
SKCM	chr11	70414591	Missense_Mutation	novel	Q114P	0.21
SKCM	chr11	70431228	Missense_Mutation	rs61885860	S405L	0.18
SKCM	chr11	70435103	Missense_Mutation	novel	G532R	0.1
SKCM	chr11	70436326	3'UTR	novel		0.25
SKCM	chr11	70419780	Silent	NA	I201I	0.26
SKCM	chr11	70435176	3'UTR	rs112108792		0.5
SKCM	chr11	70429062	Missense_Mutation	NA	T347A	0.06
SKCM	chr11	70435653	3'UTR	novel		0.52
SKCM	chr11	70417109	Missense_Mutation	NA	H185L	0.3
SKCM	chr11	70421493	Missense_Mutation	NA	K272E	0.32
SKCM	chr11	70433272	Missense_Mutation	novel	P480S	0.31
SKCM	chr11	70419752	Missense_Mutation	NA	S192F	0.21
SKCM	chr11	70407353	Missense_Mutation	novel	A19V	0.43
SKCM	chr11	70436217	3'UTR	novel		0.31
STAD	chr11	70436257	3'UTR	novel		0.24
STAD	chr11	70407550	Silent	NA	G40G	0.17
STAD	chr11	70415687	Missense_Mutation	NA	G143R	0.09
STAD	chr11	70420489	Nonsense_Mutation	NA	Q257*	0.25
STAD	chr11	70433705	Silent	rs112839434	Y501Y	0.19
STAD	chr11	70433215	Missense_Mutation	novel	G461S	0.27
STAD	chr11	70436386	3'UTR	novel		0.22
STAD	chr11	70420486	Missense_Mutation	NA	L256M	0.36
STAD	chr11	70436475	3'UTR	rs530937755		0.09
STAD	chr11	70431233	Missense_Mutation	rs534661512	A407T	0.17
STAD	chr11	70422828	Intron	novel		0.23
STAD	chr11	70433695	Missense_Mutation	NA	V498A	0.11
STAD	chr11	70414563	Nonsense_Mutation	NA	Q105*	0.62
STAD	chr11	70431228	Missense_Mutation	rs61885860	S405L	0.25
STAD	chr11	70419833	Missense_Mutation	rs373870325	T219M	0.28
STAD	chr11	70419807	Silent	NA	A210A	0.22
STAD	chr11	70436516	3'UTR	novel		0.15
STAD	chr11	70435155	Missense_Mutation	rs778284858	R549Q	0.29
UCEC	chr11	70433105	Missense_Mutation	NA	A424V	0.29
UCEC	chr11	70421498	Silent	rs561015224	F273F	0.42
UCEC	chr11	70435220	3'UTR	novel		0.27
UCEC	chr11	70429078	Missense_Mutation	NA	A352V	0.43
UCEC	chr11	70414568	Silent	NA	S106S	0.37
UCEC	chr11	70425337	Silent	rs145254957	A321A	0.39
UCEC	chr11	70422995	Missense_Mutation	novel	K319N	0.29
UCEC	chr11	70433139	Silent	novel	G435G	0.12
UCEC	chr11	70433679	Missense_Mutation	novel	L493M	0.31
UCEC	chr11	70435667	3'UTR	novel		0.35
UCEC	chr11	70435907	3'UTR	novel		0.48
UCEC	chr11	70435056	Missense_Mutation	NA	D516V	0.21
UCEC	chr11	70429095	Missense_Mutation	NA	A358T	0.19
UCEC	chr11	70422956	Silent	rs190841561	F306F	0.47
UCEC	chr11	70419807	Silent	novel	A210A	0.47
UCEC	chr11	70419807	Silent	novel	A210A	0.31
UCEC	chr11	70435569	3'UTR	rs777612042		0.52
UCEC	chr11	70421498	Silent	rs561015224	F273F	0.41
UCEC	chr11	70414614	Missense_Mutation	novel	G122R	0.44
UCEC	chr11	70417073	Missense_Mutation	NA	A173V	0.54
UCEC	chr11	70435609	3'UTR	novel		0.48
UCEC	chr11	70436533	3'UTR	novel		0.49
UCEC	chr11	70436475	3'UTR	rs530937755		0.06
UCEC	chr11	70420444	Missense_Mutation	novel	R242G	0.47
UCEC	chr11	70417057	Nonsense_Mutation	rs776466770	R168*	0.49
UCEC	chr11	70436548	3'UTR	novel		0.5
UCEC	chr11	70435405	3'UTR	novel		0.4
UCEC	chr11	70436475	3'UTR	rs530937755		0.28
UCEC	chr11	70431271	Silent	rs139350657	P419P	0.45
UCEC	chr11	70417045	Missense_Mutation	rs200865893	V164M	0.28
UCEC	chr11	70435327	3'UTR	novel		0.41
UCEC	chr11	70435767	3'UTR	rs779795316		0.36
UCEC	chr11	70433183	Missense_Mutation	novel	A450V	0.13
UCEC	chr11	70420466	Missense_Mutation	novel	G249D	0.27
UCEC	chr11	70436130	3'UTR	novel		0.25
UCEC	chr11	70419804	Silent	NA	S209S	0.33
UCEC	chr11	70433693	Silent	rs770334765	A497A	0.48
UCEC	chr11	70420489	Nonsense_Mutation	NA	Q257*	0.31
UCEC	chr11	70409837	Silent	novel	H56H	0.39
UCEC	chr11	70419767	Missense_Mutation	NA	G197D	0.19
UCEC	chr11	70420488	Silent	novel	L256L	0.2
UCEC	chr11	70421513	Missense_Mutation	novel	E278D	0.23
UCEC	chr11	70422836	Intron	novel		0.36
UCEC	chr11	70436474	3'UTR	novel		0.07
UCEC	chr11	70435030	Silent	NA	G507G	0.33
UCEC	chr11	70433105	Missense_Mutation	NA	A424V	0.44
UCEC	chr11	70419781	Missense_Mutation	novel	D202N	0.36
UVM	chr11	70435153	Silent	novel	L548L	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.122	1.2477e-08
ESCA	AMP	0.5	0.018342
LUSC	AMP	0.2974	5.606e-77
TGCT	DEL	0.72	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.00037	Kaplan-Meier Survival Analysis
KIRC	0.0061	Kaplan-Meier Survival Analysis
MESO	0.024	Kaplan-Meier Survival Analysis
UCS	0.027	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.04	Kaplan-Meier Survival Analysis
PAAD	0.0026	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
LIHC	0.0009	Kaplan-Meier Survival Analysis
LGG	0.023	Kaplan-Meier Survival Analysis
THCA	0.041	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000085733 (Gene tree)
Gene ID: 2017
Gene Symbol: CTTN
Alias: EMS1
Full Name: cortactin
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 38,181 bases
Position: chr11:70,398,404-70,436,584
Accession: 3338
Summary: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15671060	Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits.	J Cell Sci	2005 Feb 15	Zhu J	-
20004659	Cortactin is implicated in murine zygotic development.	Exp Cell Res	2010 Mar 10	Yu D	doi: 10.1016/j.yexcr.2009.11.018
23536706	Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.	Mol Biol Cell	2013 May	Ueda S	doi: 10.1091/mbc.E12-11-0782

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000482755	CTTN-206	1087	-	-	- (aa)	-	-
ENST00000529736	CTTN-213	952	-	ENSP00000431421	265 (aa)	-	H0YCD9
ENST00000498223	CTTN-208	523	-	-	- (aa)	-	-
ENST00000527962	CTTN-212	587	-	-	- (aa)	-	-
ENST00000527622	CTTN-211	597	-	-	- (aa)	-	-
ENST00000301843	CTTN-201	3272	XM_006718448	ENSP00000301843	550 (aa)	XP_006718511	Q14247
ENST00000525852	CTTN-210	1470	-	-	- (aa)	-	-
ENST00000415461	CTTN-205	1021	-	-	- (aa)	-	-
ENST00000346329	CTTN-202	3272	XM_006718447	ENSP00000317189	513 (aa)	XP_006718510	Q14247
ENST00000376561	CTTN-203	2247	-	ENSP00000365745	634 (aa)	-	Q14247
ENST00000533931	CTTN-215	567	-	ENSP00000436613	128 (aa)	-	H0YEV2
ENST00000483662	CTTN-207	736	-	-	- (aa)	-	-
ENST00000525276	CTTN-209	584	-	-	- (aa)	-	-
ENST00000393747	CTTN-204	1315	-	-	- (aa)	-	-
ENST00000532334	CTTN-214	481	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000085733	Stroke	4.2949588E-004	-
ENSG00000085733	Bronchodilator Agents	9E-7	26634245
ENSG00000085733	Forced Expiratory Volume	9E-7	26634245
ENSG00000085733	Bronchodilator Agents	1E-6	26634245
ENSG00000085733	Lung Volume Measurements	1E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000085733	rs2298396	11	70407283	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085733's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000085733	CTTN	100	92.182	ENSMUSG00000031078	Cttn	100	92.182	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	ISS	Component
GO:0002102	podosome	-	IEA	Component
GO:0005515	protein binding	15169891.15574754.16636290.17065230.17255943.17620599.18387954.19146815.19419567.21847094.22252131.22282019.24658140.25241761.	IPI	Function
GO:0005522	profilin binding	24700464.	IPI	Function
GO:0005737	cytoplasm	10760273.24700464.	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	9054437.	TAS	Component
GO:0005884	actin filament	12151401.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005905	clathrin-coated pit	-	ISS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005938	cell cortex	14742709.24700464.	IDA	Component
GO:0005938	cell cortex	-	ISS	Component
GO:0006886	intracellular protein transport	17959782.	IMP	Process
GO:0006898	receptor-mediated endocytosis	-	ISS	Process
GO:0006930	substrate-dependent cell migration, cell extension	-	IEA	Process
GO:0008076	voltage-gated potassium channel complex	12151401.	IDA	Component
GO:0030027	lamellipodium	10760273.12151401.	IDA	Component
GO:0030027	lamellipodium	-	ISS	Component
GO:0030041	actin filament polymerization	-	IEA	Process
GO:0030426	growth cone	-	ISS	Component
GO:0030516	regulation of axon extension	-	ISS	Process
GO:0030838	positive regulation of actin filament polymerization	24700464.	IMP	Process
GO:0030838	positive regulation of actin filament polymerization	-	ISS	Process
GO:0030863	cortical cytoskeleton	12151401.	IDA	Component
GO:0031532	actin cytoskeleton reorganization	-	ISS	Process
GO:0043197	dendritic spine	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045987	positive regulation of smooth muscle contraction	24700464.	IMP	Process
GO:0048041	focal adhesion assembly	-	ISS	Process
GO:0048812	neuron projection morphogenesis	-	ISS	Process
GO:0048870	cell motility	-	ISS	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0097062	dendritic spine maintenance	-	IEA	Process
GO:0097581	lamellipodium organization	-	ISS	Process
GO:1903146	regulation of autophagy of mitochondrion	-	IEA	Process
GO:1990023	mitotic spindle midzone	-	IEA	Component
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	IEA	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.