EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23702379Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.Pathol Res Pract2013 JunNoh SJdoi: 10.1016/j.prp.2013.03.011
19207554Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma.Dis Esophagus2009Hsu KFdoi: 10.1111/j.1442-2050.2008.00921.x
19242064Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters.Dis Markers2009Lee YYdoi: 10.3233/DMA-2009-0598.
24970760Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells.Carcinogenesis2014 NovLin CWdoi: 10.1093/carcin/bgu139
24265417G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.Arterioscler Thromb Vasc Biol2014 FebMajumder Sdoi: 10.1161/ATVBAHA.113.302689
19898426Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression.Mod Pathol2010 FebXu XZdoi: 10.1038/modpathol.2009.157
23030700The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.APMIS2013 MarTsai WCdoi: 10.1111/j.1600-0463.2012.02952.x
23161539The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.J Biol Chem2013 Jan 11Shimamura Sdoi: 10.1074/jbc.M112.386722
25212831Vascular endothelial growth factor-C upregulates cortactin and promotes metastasis of esophageal squamous cell carcinoma.Ann Surg Oncol2014 DecSu CMdoi: 10.1245/s10434-014-4009-7
17178864Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.Cancer Res2006 Dec 15Luo ML-
17292556Roles of cortactin in tumor pathogenesis.Biochim Biophys Acta2007 JunBuday L-
30562756ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.Cell Physiol Biochem2018Lang Ldoi: 10.1159/000496048
26151562Cortactin promotes colon cancer progression by regulating ERK pathway.Int J Oncol2015 SepNi QFdoi: 10.3892/ijo.2015.3072
19885549Localization of cortactin is associated with colorectal cancer development.Int J Oncol2009 DecHirakawa H-
24549769Extravasation during bladder cancer metastasis requires cortactinmediated invadopodia formation.Mol Med Rep2014 AprTokui Ndoi: 10.3892/mmr.2014.1965
16261345Dominant expression of 85-kDa form of cortactin in colorectal cancer.J Cancer Res Clin Oncol2006 FebZhang LH-
21858086GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.PLoS One2011Hashimoto Adoi: 10.1371/journal.pone.0023359
16442522Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.Exp Cell Res2006 May 1Bowden ET-
17510372Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters.J Histochem Cytochem2007 SepTsai WC-
16636290Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.Proc Natl Acad Sci U S A2006 May 2Hashimoto S-
22377015Cortactin and focal adhesion kinase as predictors of cancer risk in patients with premalignant oral epithelial lesions.Oral Oncol2012 Julde Vicente JCdoi: 10.1016/j.oraloncology.2012.02.004
21503569microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein.Int J Mol Med2011 SepZhang Ldoi: 10.3892/ijmm.2011.679
26112958Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma.Int J Exp Pathol2015 AugHou Hdoi: 10.1111/iep.12132
22050448Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.Int J Urol2012 JanNakane Kdoi: 10.1111/j.1442-2042.2011.02888.x
16652145Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells.Oncogene2006 Oct 5Hill A-
21418910[A pivotal role of cortactin, a CTTN encoding protein, in endocytosis of human colon cancer].Zhonghua Yi Xue Za Zhi2011 Feb 15Zhu JW-
26952924miR-542-3p inhibits the growth and invasion of colorectal cancer cells through targeted regulation of cortactin.Int J Mol Med2016 AprLong HCdoi: 10.3892/ijmm.2016.2505
21257711An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.Cancer Res2011 Mar 1Mader CCdoi: 10.1158/0008-5472.CAN-10-1432
24867096FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.Tumour Biol2014 SepCen Gdoi: 10.1007/s13277-014-2104-9
22089141HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin.Oncol Rep2012 MarZuo Qdoi: 10.3892/or.2011.1553
22944623Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.J Clin Pathol2012 DecHou Hdoi: 10.1136/jclinpath-2012-200940
18406052Cortactin in tumor invasiveness.Cancer Lett2008 Jul 8Weaver AMdoi: 10.1016/j.canlet.2008.02.066
21258212Cortactin: a multifunctional regulator of cellular invasiveness.Cell Adh Migr2011 Mar-AprKirkbride KC-
21646305Cortactin and focal adhesion kinase as predictors of cancer risk in patients with laryngeal premalignancy.Cancer Prev Res (Phila)2011 AugRodrigo JPdoi: 10.1158/1940-6207.CAPR-10-0338
24465712pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).PLoS One2014 Jan 22Radhakrishnan VMdoi: 10.1371/journal.pone.0085796
27572123Actin bundling by dynamin2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.Int J Oncol2016 SepYamada Hdoi: 10.3892/ijo.2016.3592
28404950High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin.Oncotarget2017 May 30Wang ZNdoi: 10.18632/oncotarget.15873.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1170435129SilentnovelL540L0.13
BLCAchr1170435078Missense_MutationnovelE523D0.23
BLCAchr1170433155Missense_MutationnovelE441K0.08
BLCAchr1170420399Splice_SitenovelX227_splice0.11
BLCAchr1170435123Silentrs545888686Y538Y0.35
BLCAchr1170421541Missense_MutationnovelD288N0.06
BLCAchr1170409843SilentnovelL58L0.26
BLCAchr1170431226SilentNAV404V0.47
BLCAchr1170422986SilentNAR316R0.32
BLCAchr1170433183Missense_MutationnovelA450G0.3
BLCAchr1170422908Intronnovel0.63
BLCAchr1170435037Missense_MutationNAE510K0.22
BLCAchr1170419823Missense_Mutationrs769315862Q216E0.79
BLCAchr1170435055Missense_MutationnovelD516N0.06
BLCAchr1170417121Missense_MutationnovelR189K0.39
BRCAchr11704362173'UTRnovel0.19
BRCAchr11704351903'UTRnovel0.43
BRCAchr1170433686Missense_MutationNAI495S0.29
CESCchr11704361763'UTRnovel0.3
CESCchr1170433697Missense_Mutationrs774668913A499T0.3
CESCchr11704361483'UTRnovel0.21
CESCchr1170419807SilentnovelA210A0.42
CESCchr11704356193'UTRnovel0.33
CESCchr1170407353Missense_MutationnovelA19V0.23
CESCchr1170419843Silentrs567805186H222H0.38
CESCchr1170431216Missense_Mutationrs532238783T401M0.37
CESCchr1170433184SilentnovelA450A0.46
CESCchr1170435100Missense_Mutationrs200712952R531C0.4
CESCchr1170433661Missense_Mutationrs144726386D487N0.23
CESCchr1170429075Missense_MutationNAR351T0.13
CESCchr11704364403'UTRnovel0.69
COADchr1170422746Intronnovel0.16
COADchr1170422884Intronnovel0.21
COADchr1170414551Missense_Mutationrs777502801G101S0.15
COADchr1170417101Silentrs542706268T182T0.39
COADchr1170431217SilentNAT401T0.25
COADchr1170414609Missense_MutationNAG120V0.23
COADchr1170435102Silentrs200713620R531R0.35
COADchr1170435090Silentrs772572367D527D0.27
COADchr1170414647Missense_MutationNAD133Y0.24
COADchr1170414568SilentNAS106S0.21
COADchr1170407345SilentNAD16D0.4
ESCAchr1170435031Missense_Mutationrs369658947D508N0.11
GBMchr1170420432Missense_Mutationrs567039880V238M0.27
GBMchr1170431215Missense_MutationnovelT401A0.15
GBMchr11704357903'UTRnovel0.2
GBMchr1170431229Silentrs747575729S405S0.19
GBMchr1170429163Missense_MutationnovelE380D0.64
GBMchr1170433677Missense_MutationnovelD492V0.2
HNSCchr1170414550Silentrs574999868V100V0.16
HNSCchr11704362913'UTRnovel0.83
HNSCchr1170417040Missense_MutationNAY162C0.22
HNSCchr1170435155Missense_Mutationrs778284858R549Q0.23
HNSCchr1170435103Missense_MutationnovelG532W0.08
HNSCchr1170425374Frame_Shift_DelnovelQ335Lfs*50.12
HNSCchr1170419780SilentNAI201I0.04
HNSCchr1170407530Missense_MutationnovelE34K0.21
HNSCchr1170419767Missense_MutationNAG197D0.07
HNSCchr11704356313'UTRnovel0.03
HNSCchr11704357673'UTRrs7797953160.06
HNSCchr1170435104Missense_MutationnovelG532V0.21
HNSCchr1170425331Splice_SiteNAX320_splice0.26
HNSCchr1170417086Missense_MutationnovelD177E0.09
KIRPchr11704364153'UTRnovel0.41
LGGchr1170429199Splice_RegionnovelE392E0.15
LGGchr1170429166Silentrs762293997R381R0.15
LGGchr1170415697Missense_MutationNAE146G0.37
LIHCchr1170414617Missense_MutationNAG123S0.34
LIHCchr1170422957Missense_MutationNAG307S0.4
LIHCchr11704351853'UTRnovel0.17
LUADchr1170422918Intronnovel0.16
LUADchr11704363033'UTRnovel0.26
LUADchr1170433154Silentrs202171066T440T0.15
LUADchr1170433193SilentNAY453Y0.18
LUADchr1170407517Splice_SiteNAX30_splice0.18
LUADchr1170431188Splice_Regionnovel0.21
LUADchr1170435160Nonstop_Mutationnovel*551Eext*760.19
LUADchr1170433134Nonsense_MutationnovelR434*0.06
LUADchr1170431218Frame_Shift_DelnovelP403Lfs*290.26
LUADchr1170417068Missense_MutationNAK171N0.32
LUADchr1170433676Missense_MutationNAD492Y0.17
LUADchr1170433221Missense_MutationNAA463P0.26
LUADchr11704356913'UTRnovel0.23
LUSCchr11704351813'UTRnovel0.31
LUSCchr1170421475Nonsense_MutationnovelK266*0.25
LUSCchr1170435091Missense_MutationNAG528R0.26
LUSCchr1170417019Missense_MutationnovelS155F0.34
LUSCchr1170414557Missense_MutationnovelE103Q0.48
LUSCchr1170414561Missense_MutationNAY104C0.27
LUSCchr1170420421Missense_MutationNAG234E0.19
OVchr1170433647Missense_MutationnovelE482A0.15
OVchr1170435054SilentnovelP515P0.12
OVchr1170422970Missense_MutationNAG311A0.4
OVchr11704364723'UTRnovel0.1
OVchr11704364733'UTRnovel0.1
PAADchr1170422807Intronnovel0.19
PAADchr1170435119Missense_Mutationrs769689288R537Q0.03
PCPGchr11704352213'UTRnovel0.5
PRADchr1170422831Intronnovel0.44
PRADchr1170419842Missense_MutationnovelH222R0.39
PRADchr1170422929Intronnovel0.23
READchr1170407345SilentNAD16D0.5
READchr1170431217SilentNAT401T0.28
READchr1170420456Frame_Shift_DelnovelC246Pfs*130.64
READchr1170419762Silentrs760754072F195F0.47
READchr1170433668Missense_MutationnovelY489C0.41
READchr1170433669Silentrs138763797Y489Y0.46
SARCchr11704357173'UTRnovel0.38
SARCchr1170422964Missense_MutationnovelK309R0.45
SARCchr1170409859Nonsense_MutationnovelQ64*0.16
SARCchr1170419848Frame_Shift_DelnovelQ225Rfs*50.32
SKCMchr1170414591Missense_MutationnovelQ114P0.21
SKCMchr1170431228Missense_Mutationrs61885860S405L0.18
SKCMchr1170435103Missense_MutationnovelG532R0.1
SKCMchr11704363263'UTRnovel0.25
SKCMchr1170419780SilentNAI201I0.26
SKCMchr11704351763'UTRrs1121087920.5
SKCMchr1170429062Missense_MutationNAT347A0.06
SKCMchr11704356533'UTRnovel0.52
SKCMchr1170417109Missense_MutationNAH185L0.3
SKCMchr1170421493Missense_MutationNAK272E0.32
SKCMchr1170433272Missense_MutationnovelP480S0.31
SKCMchr1170419752Missense_MutationNAS192F0.21
SKCMchr1170407353Missense_MutationnovelA19V0.43
SKCMchr11704362173'UTRnovel0.31
STADchr11704362573'UTRnovel0.24
STADchr1170407550SilentNAG40G0.17
STADchr1170415687Missense_MutationNAG143R0.09
STADchr1170420489Nonsense_MutationNAQ257*0.25
STADchr1170433705Silentrs112839434Y501Y0.19
STADchr1170433215Missense_MutationnovelG461S0.27
STADchr11704363863'UTRnovel0.22
STADchr1170420486Missense_MutationNAL256M0.36
STADchr11704364753'UTRrs5309377550.09
STADchr1170431233Missense_Mutationrs534661512A407T0.17
STADchr1170422828Intronnovel0.23
STADchr1170433695Missense_MutationNAV498A0.11
STADchr1170414563Nonsense_MutationNAQ105*0.62
STADchr1170431228Missense_Mutationrs61885860S405L0.25
STADchr1170419833Missense_Mutationrs373870325T219M0.28
STADchr1170419807SilentNAA210A0.22
STADchr11704365163'UTRnovel0.15
STADchr1170435155Missense_Mutationrs778284858R549Q0.29
UCECchr1170433105Missense_MutationNAA424V0.29
UCECchr1170421498Silentrs561015224F273F0.42
UCECchr11704352203'UTRnovel0.27
UCECchr1170429078Missense_MutationNAA352V0.43
UCECchr1170414568SilentNAS106S0.37
UCECchr1170425337Silentrs145254957A321A0.39
UCECchr1170422995Missense_MutationnovelK319N0.29
UCECchr1170433139SilentnovelG435G0.12
UCECchr1170433679Missense_MutationnovelL493M0.31
UCECchr11704356673'UTRnovel0.35
UCECchr11704359073'UTRnovel0.48
UCECchr1170435056Missense_MutationNAD516V0.21
UCECchr1170429095Missense_MutationNAA358T0.19
UCECchr1170422956Silentrs190841561F306F0.47
UCECchr1170419807SilentnovelA210A0.47
UCECchr1170419807SilentnovelA210A0.31
UCECchr11704355693'UTRrs7776120420.52
UCECchr1170421498Silentrs561015224F273F0.41
UCECchr1170414614Missense_MutationnovelG122R0.44
UCECchr1170417073Missense_MutationNAA173V0.54
UCECchr11704356093'UTRnovel0.48
UCECchr11704365333'UTRnovel0.49
UCECchr11704364753'UTRrs5309377550.06
UCECchr1170420444Missense_MutationnovelR242G0.47
UCECchr1170417057Nonsense_Mutationrs776466770R168*0.49
UCECchr11704365483'UTRnovel0.5
UCECchr11704354053'UTRnovel0.4
UCECchr11704364753'UTRrs5309377550.28
UCECchr1170431271Silentrs139350657P419P0.45
UCECchr1170417045Missense_Mutationrs200865893V164M0.28
UCECchr11704353273'UTRnovel0.41
UCECchr11704357673'UTRrs7797953160.36
UCECchr1170433183Missense_MutationnovelA450V0.13
UCECchr1170420466Missense_MutationnovelG249D0.27
UCECchr11704361303'UTRnovel0.25
UCECchr1170419804SilentNAS209S0.33
UCECchr1170433693Silentrs770334765A497A0.48
UCECchr1170420489Nonsense_MutationNAQ257*0.31
UCECchr1170409837SilentnovelH56H0.39
UCECchr1170419767Missense_MutationNAG197D0.19
UCECchr1170420488SilentnovelL256L0.2
UCECchr1170421513Missense_MutationnovelE278D0.23
UCECchr1170422836Intronnovel0.36
UCECchr11704364743'UTRnovel0.07
UCECchr1170435030SilentNAG507G0.33
UCECchr1170433105Missense_MutationNAA424V0.44
UCECchr1170419781Missense_MutationnovelD202N0.36
UVMchr1170435153SilentnovelL548L0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.1221.2477e-08
ESCAAMP0.50.018342
LUSCAMP0.29745.606e-77
TGCTDEL0.720.21504

Survival Analysis
CancerP-value Q-value
THYM0.00037

Kaplan-Meier Survival Analysis

KIRC0.0061

Kaplan-Meier Survival Analysis

MESO0.024

Kaplan-Meier Survival Analysis

UCS0.027

Kaplan-Meier Survival Analysis

HNSC0.00011

Kaplan-Meier Survival Analysis

SKCM0.04

Kaplan-Meier Survival Analysis

PAAD0.0026

Kaplan-Meier Survival Analysis

CESC0.014

Kaplan-Meier Survival Analysis

LIHC0.0009

Kaplan-Meier Survival Analysis

LGG0.023

Kaplan-Meier Survival Analysis

THCA0.041

Kaplan-Meier Survival Analysis

UVM0.017

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000085733 (Gene tree)
Gene ID
2017
Gene Symbol
CTTN
Alias
EMS1
Full Name
cortactin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
38,181 bases
Position
chr11:70,398,404-70,436,584
Accession
3338
RBP type
non-canonical RBP
Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15671060Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits.J Cell Sci2005 Feb 15Zhu J-
20004659Cortactin is implicated in murine zygotic development.Exp Cell Res2010 Mar 10Yu Ddoi: 10.1016/j.yexcr.2009.11.018
23536706Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.Mol Biol Cell2013 MayUeda Sdoi: 10.1091/mbc.E12-11-0782
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000482755CTTN-2061087--- (aa)--
ENST00000529736CTTN-213952-ENSP00000431421265 (aa)-H0YCD9
ENST00000498223CTTN-208523--- (aa)--
ENST00000527962CTTN-212587--- (aa)--
ENST00000527622CTTN-211597--- (aa)--
ENST00000301843CTTN-2013272XM_006718448ENSP00000301843550 (aa)XP_006718511Q14247
ENST00000525852CTTN-2101470--- (aa)--
ENST00000415461CTTN-2051021--- (aa)--
ENST00000346329CTTN-2023272XM_006718447ENSP00000317189513 (aa)XP_006718510Q14247
ENST00000376561CTTN-2032247-ENSP00000365745634 (aa)-Q14247
ENST00000533931CTTN-215567-ENSP00000436613128 (aa)-H0YEV2
ENST00000483662CTTN-207736--- (aa)--
ENST00000525276CTTN-209584--- (aa)--
ENST00000393747CTTN-2041315--- (aa)--
ENST00000532334CTTN-214481--- (aa)--
Gene Model
Click here to download ENSG00000085733's gene model file
Pathways
Pathway IDPathway NameSource
hsa04530Tight junctionKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
hsa05131ShigellosisKEGG
hsa05205Proteoglycans in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000085733Stroke4.2949588E-004-
ENSG00000085733Bronchodilator Agents9E-726634245
ENSG00000085733Forced Expiratory Volume9E-726634245
ENSG00000085733Bronchodilator Agents1E-626634245
ENSG00000085733Lung Volume Measurements1E-626634245
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000085733rs22983961170407283?Lung function (FEV1/FVC)30595370EFO_0004713
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085733's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000085733CTTN10092.182ENSMUSG00000031078Cttn10092.182Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001726ruffle-ISSComponent
GO:0002102podosome-IEAComponent
GO:0005515protein binding15169891.15574754.16636290.17065230.17255943.17620599.18387954.19146815.19419567.21847094.22252131.22282019.24658140.25241761.IPIFunction
GO:0005522profilin binding24700464.IPIFunction
GO:0005737cytoplasm10760273.24700464.IDAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005794Golgi apparatus-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton9054437.TASComponent
GO:0005884actin filament12151401.IDAComponent
GO:0005886plasma membrane-IDAComponent
GO:0005905clathrin-coated pit-ISSComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005938cell cortex14742709.24700464.IDAComponent
GO:0005938cell cortex-ISSComponent
GO:0006886intracellular protein transport17959782.IMPProcess
GO:0006898receptor-mediated endocytosis-ISSProcess
GO:0006930substrate-dependent cell migration, cell extension-IEAProcess
GO:0008076voltage-gated potassium channel complex12151401.IDAComponent
GO:0030027lamellipodium10760273.12151401.IDAComponent
GO:0030027lamellipodium-ISSComponent
GO:0030041actin filament polymerization-IEAProcess
GO:0030426growth cone-ISSComponent
GO:0030516regulation of axon extension-ISSProcess
GO:0030838positive regulation of actin filament polymerization24700464.IMPProcess
GO:0030838positive regulation of actin filament polymerization-ISSProcess
GO:0030863cortical cytoskeleton12151401.IDAComponent
GO:0031532actin cytoskeleton reorganization-ISSProcess
GO:0043197dendritic spine-IEAComponent
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045987positive regulation of smooth muscle contraction24700464.IMPProcess
GO:0048041focal adhesion assembly-ISSProcess
GO:0048812neuron projection morphogenesis-ISSProcess
GO:0048870cell motility-ISSProcess
GO:0061024membrane organization-TASProcess
GO:0097062dendritic spine maintenance-IEAProcess
GO:0097581lamellipodium organization-ISSProcess
GO:1903146regulation of autophagy of mitochondrion-IEAProcess
GO:1990023mitotic spindle midzone-IEAComponent
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEAProcess
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