EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29867202	Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.	Oncogene	2018 Oct	Ahmat Amin MKB	doi: 10.1038/s41388-018-0286-0
18264096	Multiple loci identified in a genome-wide association study of prostate cancer.	Nat Genet	2008 Mar	Thomas G	doi: 10.1038/ng.91
20010870	Copine-III interacts with ErbB2 and promotes tumor cell migration.	Oncogene	2010 Mar 18	Heinrich C	doi: 10.1038/onc.2009.456
26719032	Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells.	Oncol Rep	2016 Feb	Choi HY	doi: 10.3892/or.2015.4472

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr8	86548434	Missense_Mutation	rs781021543	A338V	0.24
BLCA	chr8	86548343	Missense_Mutation	novel	P308A	0.23
BLCA	chr8	86558522	3'UTR	novel		0.22
BLCA	chr8	86558475	3'UTR	novel		0.15
BLCA	chr8	86551052	Silent	novel	K340K	0.23
BLCA	chr8	86540293	Missense_Mutation	novel	L198V	0.1
BLCA	chr8	86556176	Missense_Mutation	NA	N443K	0.48
BLCA	chr8	86556119	Silent	novel	L424L	0.42
BLCA	chr8	86556181	Missense_Mutation	novel	S445F	0.43
BLCA	chr8	86546642	Missense_Mutation	novel	S260R	0.19
BLCA	chr8	86528587	Silent	novel	S14S	0.1
BLCA	chr8	86540282	Missense_Mutation	novel	F194S	0.07
BRCA	chr8	86537582	Missense_Mutation	NA	D160V	0.18
BRCA	chr8	86531196	In_Frame_Del	novel	K118_T119delinsN	0.05
BRCA	chr8	86547709	Splice_Site	novel	X274_splice	0.12
BRCA	chr8	86556168	Missense_Mutation	rs768025237	I441V	0.44
BRCA	chr8	86556285	Missense_Mutation	novel	E480K	0.08
CESC	chr8	86540289	Missense_Mutation	NA	I196M	0.16
CESC	chr8	86547756	Nonsense_Mutation	NA	Q289*	0.21
CESC	chr8	86551047	Missense_Mutation	novel	D339N	0.07
CESC	chr8	86505272	Intron	NA		0.6
CESC	chr8	86548310	Missense_Mutation	novel	D297N	0.45
COAD	chr8	86531168	Frame_Shift_Ins	NA	*K110Efs24**	0.23
COAD	chr8	86528968	Silent	NA	K52K	0.13
COAD	chr8	86529078	Missense_Mutation	NA	L89P	0.15
COAD	chr8	86548434	Missense_Mutation	rs781021543	A338V	0.07
COAD	chr8	86546618	Frame_Shift_Ins	rs751554216	*R255Kfs19**	0.34
COAD	chr8	86547755	Silent	NA	C288C	0.36
COAD	chr8	86554940	Missense_Mutation	rs148215511	V404M	0.38
COAD	chr8	86547564	Intron	novel		0.08
COAD	chr8	86551207	Missense_Mutation	NA	F365V	0.48
COAD	chr8	86529011	Missense_Mutation	NA	Y67N	0.09
COAD	chr8	86558293	Frame_Shift_Del	NA	*E501Kfs107**	0.36
COAD	chr8	86529059	Missense_Mutation	rs143209735	D83N	0.31
COAD	chr8	86551205	Missense_Mutation	novel	N364S	0.08
COAD	chr8	86558392	Silent	rs756944839	T532T	0.26
GBM	chr8	86540289	Silent	novel	I196I	0.06
HNSC	chr8	86554892	Nonsense_Mutation	novel	Q388*	0.29
HNSC	chr8	86540286	Silent	novel	K195K	0.06
HNSC	chr8	86532530	Missense_Mutation	novel	D137Y	0.05
HNSC	chr8	86554905	Missense_Mutation	novel	Y392C	0.29
KIRC	chr8	86556242	Missense_Mutation	rs763399183	E465D	0.31
LAML	chr8	86544806	Missense_Mutation	NA	T234A	0.29
LGG	chr8	86556333	Nonsense_Mutation	novel	Q496*	0.11
LGG	chr8	86547713	Splice_Region	NA	I274I	0.41
LIHC	chr8	86544812	Missense_Mutation	novel	L236V	0.23
LIHC	chr8	86537589	Nonsense_Mutation	NA	Y162*	0.14
LUAD	chr8	86558357	Missense_Mutation	NA	T521A	0.23
LUAD	chr8	86529019	Missense_Mutation	novel	F69L	0.14
LUAD	chr8	86547771	Splice_Site	novel	X293_splice	0.54
LUAD	chr8	86540310	Silent	rs376893060	Y203Y	0.27
LUAD	chr8	86556128	Silent	novel	T427T	0.2
LUAD	chr8	86537628	Silent	novel	L175L	0.06
LUAD	chr8	86558320	Missense_Mutation	novel	L508F	0.04
LUAD	chr8	86558321	Missense_Mutation	novel	A509S	0.04
LUSC	chr8	86528973	Missense_Mutation	novel	C54F	0.22
LUSC	chr8	86529125	Splice_Site	novel	X104_splice	0.25
LUSC	chr8	86556298	Missense_Mutation	novel	R484T	0.12
LUSC	chr8	86556113	Silent	novel	V422V	0.22
LUSC	chr8	86548428	Missense_Mutation	novel	Y336C	0.11
LUSC	chr8	86540319	Missense_Mutation	novel	M206I	0.35
LUSC	chr8	86540320	Missense_Mutation	novel	D207Y	0.34
LUSC	chr8	86548399	Silent	novel	L326L	0.1
LUSC	chr8	86548418	Frame_Shift_Ins	novel	*Q334Sfs4**	0.35
LUSC	chr8	86528973	Missense_Mutation	novel	C54S	0.45
LUSC	chr8	86556240	Missense_Mutation	novel	E465Q	0.22
LUSC	chr8	86554961	Missense_Mutation	novel	A411T	0.28
LUSC	chr8	86532551	Missense_Mutation	NA	E144Q	0.06
LUSC	chr8	86537638	Missense_Mutation	rs781107778	R179W	0.36
LUSC	chr8	86528952	Missense_Mutation	rs376221396	R47H	0.36
OV	chr8	86558731	3'UTR	novel		0.18
OV	chr8	86548304	Missense_Mutation	NA	G295R	0.2
PAAD	chr8	86537631	Missense_Mutation	novel	M176I	0.2
PAAD	chr8	86537638	Missense_Mutation	rs781107778	R179W	0.04
PRAD	chr8	86537579	Nonsense_Mutation	NA	S159*	0.37
PRAD	chr8	86558347	Silent	novel	G517G	0.44
READ	chr8	86556314	Missense_Mutation	NA	F489L	0.37
READ	chr8	86551198	Missense_Mutation	novel	P362S	0.05
READ	chr8	86532521	Nonsense_Mutation	novel	E134*	0.44
READ	chr8	86554917	Missense_Mutation	novel	N396T	0.32
SKCM	chr8	86554980	Missense_Mutation	NA	A417V	0.25
SKCM	chr8	86544795	Missense_Mutation	NA	Q230R	0.3
SKCM	chr8	86548309	Silent	NA	V296V	0.22
SKCM	chr8	86554889	Missense_Mutation	NA	P387S	0.3
SKCM	chr8	86544781	Silent	NA	L225L	0.33
SKCM	chr8	86556309	Nonsense_Mutation	NA	Q488*	0.47
SKCM	chr8	86558401	Silent	NA	Q535Q	0.29
SKCM	chr8	86548404	Missense_Mutation	novel	S328F	0.27
SKCM	chr8	86528991	Missense_Mutation	NA	S60F	0.38
STAD	chr8	86554966	Silent	rs2304788	T412T	0.13
STAD	chr8	86554970	Nonsense_Mutation	rs781427442	Q414*	0.23
STAD	chr8	86546634	Frame_Shift_Del	rs761955273	*S260Afs10**	0.17
STAD	chr8	86531228	Missense_Mutation	rs76328401	T129M	0.23
STAD	chr8	86528995	Missense_Mutation	NA	K61N	0.25
STAD	chr8	86558486	3'UTR	novel		0.15
STAD	chr8	86548358	Missense_Mutation	NA	Y313H	0.15
STAD	chr8	86556291	Missense_Mutation	NA	A482T	0.2
STAD	chr8	86528591	Missense_Mutation	novel	A16S	0.15
STAD	chr8	86531204	Missense_Mutation	novel	R121T	0.17
THCA	chr8	86537615	Nonsense_Mutation	novel	*D171delinsEVLYSI**	0.08
UCEC	chr8	86537567	Missense_Mutation	NA	L155R	0.37
UCEC	chr8	86558490	3'UTR	novel		0.33
UCEC	chr8	86547632	Intron	novel		0.39
UCEC	chr8	86546633	Missense_Mutation	NA	K257N	0.54
UCEC	chr8	86528952	Missense_Mutation	rs376221396	R47H	0.39
UCEC	chr8	86531181	Silent	NA	R113R	0.49
UCEC	chr8	86544837	Missense_Mutation	novel	P244H	0.35
UCEC	chr8	86544822	Missense_Mutation	NA	A239D	0.06
UCEC	chr8	86556218	Silent	NA	G457G	0.2
UCEC	chr8	86531179	Nonsense_Mutation	rs779231067	R113*	0.45
UCEC	chr8	86548304	Missense_Mutation	NA	G295R	0.23
UCEC	chr8	86547713	Missense_Mutation	novel	I274M	0.35
UCEC	chr8	86546634	Frame_Shift_Del	rs761955273	*S260Afs10**	0.5
UCEC	chr8	86556234	Missense_Mutation	rs779563300	A463T	0.14
UCEC	chr8	86556165	Missense_Mutation	NA	A440T	0.31
UCEC	chr8	86547678	Intron	novel		0.27
UCEC	chr8	86546621	Missense_Mutation	novel	K253N	0.23
UCEC	chr8	86558427	3'UTR	novel		0.38
UCEC	chr8	86546634	Frame_Shift_Del	rs761955273	*S260Afs10**	0.44
UCEC	chr8	86547527	Intron	novel		0.5
UCEC	chr8	86551222	Missense_Mutation	novel	P370S	0.39
UCEC	chr8	86558391	Missense_Mutation	rs761276717	T532M	0.38
UCEC	chr8	86546619	Frame_Shift_Del	NA	*R255Gfs15**	0.51
UCEC	chr8	86529058	Silent	rs770032983	I82I	0.22
UCEC	chr8	86546641	Missense_Mutation	novel	S260N	0.27
UCEC	chr8	86547626	Intron	novel		0.37
UCEC	chr8	86558486	3'UTR	novel		0.27
UCEC	chr8	86547698	Intron	novel		0.54
UCEC	chr8	86551194	Silent	novel	E360E	0.34
UCEC	chr8	86540270	Missense_Mutation	novel	V190D	0.43
UCEC	chr8	86544805	Missense_Mutation	novel	M233I	0.15
UCEC	chr8	86528952	Missense_Mutation	rs376221396	R47H	0.32
UCEC	chr8	86532508	Splice_Site	NA	X130_splice	0.32
UCEC	chr8	86551203	Missense_Mutation	NA	M363I	0.29
UCEC	chr8	86531204	Missense_Mutation	novel	R121I	0.36
UCEC	chr8	86532508	Splice_Site	novel	X130_splice	0.21
UCEC	chr8	86556284	Silent	rs562012874	G479G	0.35
UCEC	chr8	86528554	Silent	novel	A3A	0.33
UCEC	chr8	86537626	Silent	novel	L175L	0.47
UCEC	chr8	86554947	Missense_Mutation	novel	R406M	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.1004	0.15559
PRAD	AMP	0.2541	3.7005e-05
READ	DEL	0.0303	0.20625
SARC	AMP	0.2957	0.18425
TGCT	AMP	0.6733	0.13696
THCA	DEL	0.008	0.038162

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0073	Kaplan-Meier Survival Analysis
SKCM	0.00042	Kaplan-Meier Survival Analysis
BRCA	0.02	Kaplan-Meier Survival Analysis
KIRP	0.022	Kaplan-Meier Survival Analysis
COAD	0.025	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
LAML	0.027	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
THCA	0.022	Kaplan-Meier Survival Analysis
UVM	0.008	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000085719 (Gene tree)
Gene ID: 8895
Gene Symbol: CPNE3
Alias: N
Full Name: copine 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 47,072 bases
Position: chr8:86,514,427-86,561,498
Accession: 2316
RBP type: non-canonical RBP
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000523588	CPNE3-207	426	-	-	- (aa)	-	-
ENST00000621783	CPNE3-212	817	-	ENSP00000482002	234 (aa)	-	A0A087WYQ3
ENST00000517391	CPNE3-202	785	-	ENSP00000428561	262 (aa)	-	H0YB26
ENST00000622183	CPNE3-213	156	-	-	- (aa)	-	-
ENST00000620393	CPNE3-209	680	-	ENSP00000478894	135 (aa)	-	A0A087WUS8
ENST00000522240	CPNE3-205	446	-	ENSP00000427966	79 (aa)	-	E5RFT7
ENST00000517490	CPNE3-203	4865	XM_005251093	ENSP00000477590	537 (aa)	XP_005251150	O75131
ENST00000517862	CPNE3-204	654	-	-	- (aa)	-	-
ENST00000523469	CPNE3-206	656	-	ENSP00000429561	153 (aa)	-	E5RHZ0
ENST00000517354	CPNE3-201	566	-	-	- (aa)	-	-
ENST00000621526	CPNE3-211	279	-	ENSP00000479670	8 (aa)	-	A0A0G2JMP5
ENST00000621245	CPNE3-210	581	-	ENSP00000481234	139 (aa)	-	A0A087WXR6
ENST00000614678	CPNE3-208	4201	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000085719's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000085719	Hip	7.2950810918958E-6	17903296

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000085719	rs11781016	8	86517069	C	Blood protein levels	29875488	[0.28-0.36] unit increase	0.32	EFO_0007937
ENSG00000085719	rs11781016	8	86517069	A	Cognitive performance (MTAG)	30038396	[0.0097-0.0187] unit decrease	0.0142	EFO_0008354
ENSG00000085719	rs11781016	8	86517069	?	General cognitive ability	29844566	z-score decrease	4.516	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085719's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004674	protein serine/threonine kinase activity	11041869.	IDA	Function
GO:0005215	transporter activity	9430674.	TAS	Function
GO:0005515	protein binding	20010870.21044950.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005544	calcium-dependent phospholipid binding	20010870.	IDA	Function
GO:0005544	calcium-dependent phospholipid binding	11041869.	TAS	Function
GO:0005634	nucleus	20010870.21087455.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	20010870.21087455.	IDA	Component
GO:0005737	cytoplasm	11041869.	NAS	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	12949241.	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	20010870.21087455.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	20010870.	IDA	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0006629	lipid metabolic process	9430674.	TAS	Process
GO:0016192	vesicle-mediated transport	9430674.	TAS	Process
GO:0030054	cell junction	20010870.	IDA	Component
GO:0030335	positive regulation of cell migration	20010870.	IMP	Process
GO:0030971	receptor tyrosine kinase binding	21873635.	IBA	Function
GO:0030971	receptor tyrosine kinase binding	20010870.	IPI	Function
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0038128	ERBB2 signaling pathway	21873635.	IBA	Process
GO:0038128	ERBB2 signaling pathway	20010870.	IDA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0046474	glycerophospholipid biosynthetic process	-	TAS	Process
GO:0048306	calcium-dependent protein binding	20010870.	IDA	Function
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0071277	cellular response to calcium ion	21873635.	IBA	Process
GO:0071277	cellular response to calcium ion	20010870.21087455.	IDA	Process
GO:0071363	cellular response to growth factor stimulus	20010870.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.