EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28232072	BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.	J Mol Cell Cardiol	2017 Apr	Willis MS	doi: 10.1016/j.yjmcc.2017.02.003
24471421	Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma.	Histopathology	2014 May	Xia QY	doi: 10.1111/his.12334
25673149	The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines.	Sci Rep	2015 Feb 12	Kobayashi K	doi: 10.1038/srep08428.
12566296	Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.	Cancer Res	2003 Feb 1	Reisman DN	-
19488910	Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma.	Cancer Invest	2009 Jul	Gunduz E	doi: 10.1080/07357900802563010.
25026375	Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.	Arch Biochem Biophys	2014 Dec 1	Mehrotra A	doi: 10.1016/j.abb.2014.07.004
25808524	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.	J Cell Physiol	2015 Nov	Wu Q	doi: 10.1002/jcp.24991.
28038711	SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.	Ann Diagn Pathol	2017 Feb	Herpel E	doi: 10.1016/j.anndiagpath.2016.10.006
21092585	[Expression of BRG1 and BRM proteins in prostatic cancer].	Zhonghua Bing Li Xue Za Zhi	2010 Sep	Liu XB	-
15240517	Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.	Clin Cancer Res	2004 Jul 1	Fukuoka J	-
18923443	Hotspot mutation of Brahma in non-melanoma skin cancer.	J Invest Dermatol	2009 Apr	Moloney FJ	doi: 10.1038/jid.2008.319
23872584	A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.	Cancer Res	2013 Sep 1	Oike T	doi: 10.1158/0008-5472.CAN-12-4593
24520176	Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.	Proc Natl Acad Sci U S A	2014 Feb 25	Hoffman GR	doi: 10.1073/pnas.1316793111
28571677	BRM promoter insertion polymorphisms increase the risk of cancer: A meta-analysis.	Gene	2017 Aug 30	Ouyang X	doi: 10.1016/j.gene.2017.05.047
28602977	BRM/SMARCA2 promotes the proliferation and chemoresistance ofpancreatic cancer cells by targeting JAK2/STAT3 signaling.	Cancer Lett	2017 Aug 28	Zhang Z	doi: 10.1016/j.canlet.2017.05.006
28296015	Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma.	Liver Int	2017 Nov	Nahon P	doi: 10.1111/liv.13419
30447346	Inactivation of SMARCA2 by promoter hypermethylation drives lung cancer development.	Gene	2019 Mar 1	Wu J	doi: 10.1016/j.gene.2018.11.032
29894502	Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer.	PLoS One	2018 Jun 12	Yu Y	doi: 10.1371/journal.pone.0198873

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr9	2192779	3'UTR	novel		0.26
ACC	chr9	2077741	Missense_Mutation	novel	A717S	0.42
BLCA	chr9	2186096	Missense_Mutation	novel	I1488F	0.23
BLCA	chr9	2083369	Missense_Mutation	novel	E791K	0.71
BLCA	chr9	2159835	Intron	rs766308479		0.64
BLCA	chr9	2084139	Missense_Mutation	novel	F823L	0.25
BLCA	chr9	2115859	Missense_Mutation	novel	Q1165P	0.58
BLCA	chr9	2104016	Missense_Mutation	NA	R1047W	0.54
BLCA	chr9	2115850	Missense_Mutation	rs281875186	R1162H	0.41
BLCA	chr9	2104043	Missense_Mutation	novel	D1056H	0.29
BLCA	chr9	2033021	Missense_Mutation	novel	M99V	0.51
BLCA	chr9	2110251	Splice_Region	novel		0.2
BLCA	chr9	2054650	Missense_Mutation	novel	S367F	0.17
BLCA	chr9	2110409	Missense_Mutation	NA	P1150S	0.67
BLCA	chr9	2115849	Missense_Mutation	NA	R1162C	0.33
BLCA	chr9	2110374	Missense_Mutation	novel	A1138V	0.25
BLCA	chr9	2115870	Missense_Mutation	novel	V1169F	0.9
BLCA	chr9	2115849	Missense_Mutation	novel	R1162S	0.36
BLCA	chr9	2088542	Missense_Mutation	NA	L938I	0.1
BLCA	chr9	2086985	Missense_Mutation	NA	L895V	0.87
BLCA	chr9	2058337	Missense_Mutation	novel	Y465C	0.42
BLCA	chr9	2110333	Silent	novel	L1124L	0.25
BLCA	chr9	2047456	Missense_Mutation	novel	V340L	0.36
BLCA	chr9	2060974	Missense_Mutation	NA	R560S	0.48
BLCA	chr9	2110327	Missense_Mutation	NA	F1122L	0.44
BLCA	chr9	2119510	Missense_Mutation	rs765383428	R1246Q	0.33
BLCA	chr9	2115969	Missense_Mutation	novel	G1202S	0.3
BLCA	chr9	2077687	Missense_Mutation	novel	Q699E	0.39
BRCA	chr9	2161810	Frame_Shift_Ins	novel	*R1370Mfs23**	0.07
BRCA	chr9	2039872	Silent	rs781034714	P254P	0.48
BRCA	chr9	2088587	Missense_Mutation	NA	E953K	0.73
BRCA	chr9	2058393	Missense_Mutation	NA	H484D	0.14
BRCA	chr9	2116045	Missense_Mutation	NA	N1227S	0.34
BRCA	chr9	2088583	Missense_Mutation	NA	K951N	0.44
BRCA	chr9	2054717	Missense_Mutation	NA	Q389H	0.43
BRCA	chr9	2039490	Missense_Mutation	rs267602196	P127L	0.15
BRCA	chr9	2193411	3'UTR	novel		0.13
BRCA	chr9	2081840	Silent	rs749703040	G731G	0.77
BRCA	chr9	2076304	Missense_Mutation	NA	E671Q	0.44
BRCA	chr9	2123746	Missense_Mutation	novel	D1264H	0.1
BRCA	chr9	2181612	Nonsense_Mutation	novel	S1432*	0.06
BRCA	chr9	2110343	Missense_Mutation	NA	A1128T	0.19
BRCA	chr9	2039663	Nonsense_Mutation	NA	Q185*	0.15
BRCA	chr9	2097429	Silent	NA	L1012L	0.28
CESC	chr9	2193604	3'UTR	novel		0.41
CESC	chr9	2104063	Missense_Mutation	NA	L1062F	0.4
CESC	chr9	2073622	Missense_Mutation	novel	E645G	0.11
CESC	chr9	2081971	Missense_Mutation	novel	P775L	0.43
CESC	chr9	2086855	Silent	rs142930412	D851D	0.35
CESC	chr9	2088558	Missense_Mutation	NA	R943K	0.07
CESC	chr9	2158968	Intron	novel		0.12
CESC	chr9	2193370	3'UTR	novel		0.39
CESC	chr9	2086856	Missense_Mutation	rs281875199	E852K	0.18
CESC	chr9	2115948	Missense_Mutation	NA	D1195H	0.33
CESC	chr9	2123896	Missense_Mutation	NA	V1314M	0.11
CESC	chr9	2192851	3'UTR	novel		0.28
CESC	chr9	2193472	3'UTR	novel		0.49
CESC	chr9	2123739	Silent	NA	R1261R	0.47
CESC	chr9	2029101	Missense_Mutation	novel	L27F	0.4
COAD	chr9	2123719	Missense_Mutation	NA	R1255W	0.36
COAD	chr9	2032958	Missense_Mutation	rs762444118	D78N	0.42
COAD	chr9	2123819	Missense_Mutation	NA	D1288G	0.44
COAD	chr9	2182150	Missense_Mutation	novel	R1457C	0.34
COAD	chr9	2054628	Nonsense_Mutation	NA	E360*	0.11
COAD	chr9	2039767	Silent	NA	Q219Q	0.24
COAD	chr9	2028984	Splice_Region	novel		0.34
COAD	chr9	2158722	Intron	novel		0.44
COAD	chr9	2161816	Missense_Mutation	NA	P1371H	0.62
COAD	chr9	2115831	Missense_Mutation	NA	A1156T	0.28
COAD	chr9	2056700	Missense_Mutation	NA	R401H	0.33
COAD	chr9	2056778	Missense_Mutation	NA	R427H	0.17
COAD	chr9	2077644	Silent	rs149890563	D684D	0.09
COAD	chr9	2039827	In_Frame_Del	NA	Q242del	0.32
COAD	chr9	2115945	Missense_Mutation	novel	V1194M	0.07
COAD	chr9	2047455	Silent	rs750120946	P339P	0.19
COAD	chr9	2081995	Missense_Mutation	NA	S783L	0.22
COAD	chr9	2029048	Missense_Mutation	rs773325366	A9V	0.17
COAD	chr9	2060867	Missense_Mutation	NA	R525C	0.03
COAD	chr9	2116018	Missense_Mutation	NA	Q1218R	0.32
COAD	chr9	2084129	Missense_Mutation	NA	S820N	0.33
COAD	chr9	2054700	Missense_Mutation	NA	R384W	0.36
COAD	chr9	2058367	Missense_Mutation	NA	K475T	0.38
COAD	chr9	2081881	Missense_Mutation	NA	G745E	0.29
COAD	chr9	2115855	Missense_Mutation	NA	G1164R	0.26
COAD	chr9	2181578	Nonsense_Mutation	NA	R1421*	0.24
COAD	chr9	2076309	Nonsense_Mutation	novel	*D673Tfs2**	0.07
COAD	chr9	2161836	Missense_Mutation	NA	P1378S	0.36
COAD	chr9	2115894	Missense_Mutation	NA	V1177M	0.27
DLBC	chr9	2081900	Missense_Mutation	novel	M751I	0.11
ESCA	chr9	2193371	3'UTR	novel		0.16
ESCA	chr9	2058298	Missense_Mutation	novel	L452P	0.46
ESCA	chr9	2161902	Missense_Mutation	novel	R1400G	0.21
GBM	chr9	2191345	Silent	novel	P1558P	0.48
GBM	chr9	2056809	Missense_Mutation	novel	K437N	0.09
GBM	chr9	2119474	Missense_Mutation	novel	P1234L	0.07
GBM	chr9	2119499	Missense_Mutation	novel	M1242I	0.03
GBM	chr9	2081995	Missense_Mutation	NA	S783L	0.16
GBM	chr9	2086866	Missense_Mutation	NA	R855Q	0.59
GBM	chr9	2058333	Missense_Mutation	novel	E464K	0.11
GBM	chr9	2029232	Missense_Mutation	NA	M70I	0.42
GBM	chr9	2039894	Missense_Mutation	rs771281007	P262S	0.18
GBM	chr9	2056768	Silent	novel	R424R	0.17
GBM	chr9	2101587	Silent	novel	H1032H	0.16
GBM	chr9	2110296	Missense_Mutation	novel	F1112C	0.18
GBM	chr9	2115922	Missense_Mutation	NA	A1186V	0.48
GBM	chr9	2086980	Missense_Mutation	novel	A893V	0.1
GBM	chr9	2039586	Missense_Mutation	NA	G159D	0.34
GBM	chr9	2104169	Missense_Mutation	NA	G1098S	0.41
HNSC	chr9	2086844	Missense_Mutation	NA	M848L	0.2
HNSC	chr9	2123782	Missense_Mutation	novel	E1276K	0.19
HNSC	chr9	2097460	Missense_Mutation	novel	Q1023K	0.59
HNSC	chr9	2039700	Missense_Mutation	novel	P197L	0.85
HNSC	chr9	2192726	Missense_Mutation	rs753433101	T1587M	0.2
HNSC	chr9	2076291	Missense_Mutation	novel	S666R	0.36
HNSC	chr9	2058446	Silent	novel	E501E	0.11
HNSC	chr9	2086964	Missense_Mutation	novel	L888I	0.73
HNSC	chr9	2086853	Missense_Mutation	novel	D851N	0.19
HNSC	chr9	2086833	Missense_Mutation	NA	R844Q	0.22
HNSC	chr9	2182188	Missense_Mutation	novel	K1469N	0.07
KICH	chr9	2056812	Silent	novel	I438I	0.44
KIRC	chr9	2116050	Splice_Site	NA	X1228_splice	0.37
KIRC	chr9	2056787	Missense_Mutation	NA	E430V	0.16
KIRC	chr9	2076232	Nonsense_Mutation	novel	E647*	0.21
KIRP	chr9	2115829	Missense_Mutation	NA	Q1155L	0.1
KIRP	chr9	2115822	Missense_Mutation	novel	D1153H	0.36
KIRP	chr9	2110312	Silent	NA	S1117S	0.29
LAML	chr9	2192785	3'UTR	novel		0.05
LAML	chr9	2081904	Missense_Mutation	NA	L753F	0.3
LGG	chr9	2084102	Missense_Mutation	NA	R811H	0.45
LGG	chr9	2054698	Missense_Mutation	novel	L383R	0.06
LIHC	chr9	2115820	Splice_Site	novel	X1153_splice	0.32
LIHC	chr9	2070419	Missense_Mutation	novel	K565T	0.41
LIHC	chr9	2123922	Missense_Mutation	novel	E1322D	0.06
LIHC	chr9	2182157	Missense_Mutation	novel	H1459R	0.34
LIHC	chr9	2101571	Missense_Mutation	novel	E1027A	0.72
LIHC	chr9	2123796	Silent	rs764977538	L1280L	0.07
LIHC	chr9	2097384	Splice_Site	novel	X998_splice	0.46
LIHC	chr9	2097385	Missense_Mutation	novel	G998R	0.46
LUAD	chr9	2110400	Missense_Mutation	NA	D1147N	0.58
LUAD	chr9	2115969	Missense_Mutation	rs281875239	G1202C	0.63
LUAD	chr9	2084151	Missense_Mutation	novel	L827F	0.37
LUAD	chr9	2170433	Missense_Mutation	novel	K1405R	0.46
LUAD	chr9	2110342	Missense_Mutation	NA	R1127S	0.24
LUAD	chr9	2088558	Missense_Mutation	NA	R943I	0.77
LUAD	chr9	2123791	Missense_Mutation	NA	E1279K	0.09
LUAD	chr9	2056743	Silent	novel	Y415Y	0.17
LUAD	chr9	2058363	Nonsense_Mutation	novel	Q474*	0.07
LUAD	chr9	2101582	Missense_Mutation	NA	E1031Q	0.16
LUAD	chr9	2084172	Missense_Mutation	NA	I834M	0.25
LUAD	chr9	2086930	Missense_Mutation	novel	R876S	0.17
LUAD	chr9	2182167	Silent	novel	R1462R	0.1
LUAD	chr9	2054631	Missense_Mutation	NA	L361M	0.3
LUAD	chr9	2029134	Missense_Mutation	rs768632343	G38C	0.41
LUAD	chr9	2029135	Missense_Mutation	novel	G38V	0.38
LUAD	chr9	2182201	Missense_Mutation	NA	L1474V	0.09
LUAD	chr9	2104102	Missense_Mutation	NA	M1075I	0.18
LUAD	chr9	2115837	Missense_Mutation	novel	D1158Y	0.33
LUAD	chr9	2047450	Missense_Mutation	NA	D338Y	0.29
LUAD	chr9	2054619	Missense_Mutation	novel	R357W	0.59
LUAD	chr9	2054677	Missense_Mutation	NA	A376V	0.35
LUAD	chr9	2056747	Missense_Mutation	NA	R417W	0.42
LUSC	chr9	2029188	Missense_Mutation	NA	P56S	0.12
LUSC	chr9	2081837	Missense_Mutation	novel	Q730H	0.11
LUSC	chr9	2081948	Missense_Mutation	NA	M767I	0.62
LUSC	chr9	2159898	Intron	rs369140373		0.15
LUSC	chr9	2116022	Silent	NA	A1219A	0.16
LUSC	chr9	2058296	Silent	novel	Y451Y	0.62
LUSC	chr9	2056778	Missense_Mutation	novel	R427P	0.31
LUSC	chr9	2110347	Missense_Mutation	NA	G1129V	0.37
LUSC	chr9	2054679	Missense_Mutation	novel	T377S	0.6
LUSC	chr9	2084096	Missense_Mutation	novel	A809V	0.5
LUSC	chr9	2056728	Silent	rs771891440	L410L	0.5
LUSC	chr9	2081898	Missense_Mutation	NA	M751V	0.81
LUSC	chr9	2047369	Missense_Mutation	novel	A311P	0.21
LUSC	chr9	2058311	Frame_Shift_Del	novel	*L456Ffs51**	0.12
LUSC	chr9	2060857	Silent	rs148410896	K521K	0.32
LUSC	chr9	2039694	Missense_Mutation	NA	G195V	0.92
OV	chr9	2077763	Missense_Mutation	novel	L724Q	0.05
OV	chr9	2039892	Missense_Mutation	NA	R261K	0.28
OV	chr9	2073305	Missense_Mutation	novel	A614S	0.06	ResIII
OV	chr9	2104000	Splice_Region	novel		0.44
OV	chr9	2039872	Silent	novel	P254P	0.42
OV	chr9	2076321	Silent	NA	Q676Q	0.22
OV	chr9	2119499	Missense_Mutation	novel	M1242I	0.07
OV	chr9	2115935	Nonsense_Mutation	novel	Y1190*	0.09
OV	chr9	2110307	Nonsense_Mutation	novel	G1116*	0.06
PAAD	chr9	2073274	Silent	novel	G603G	0.14
PAAD	chr9	2104068	Missense_Mutation	rs747313863	A1064V	0.17
PAAD	chr9	2119478	Silent	rs748144678	D1235D	0.13
PRAD	chr9	2119528	Frame_Shift_Del	novel	*F1253Lfs22**	0.33
PRAD	chr9	2115841	Missense_Mutation	rs281875187	R1159Q	0.41
PRAD	chr9	2060865	Missense_Mutation	novel	R524M	0.31
READ	chr9	2086832	Missense_Mutation	NA	R844W	0.23
READ	chr9	2058432	Missense_Mutation	NA	R497W	0.47
READ	chr9	2029064	Silent	novel	G14G	0.89
READ	chr9	2032957	Silent	rs148086416	I77I	0.41
READ	chr9	2060894	Missense_Mutation	novel	D534N	0.46
READ	chr9	2086832	Missense_Mutation	NA	R844W	0.39
READ	chr9	2158787	Intron	novel		0.5
SARC	chr9	2104085	Missense_Mutation	novel	L1070M	0.65
SARC	chr9	2097414	Silent	novel	N1007N	0.63
SARC	chr9	2161707	Nonsense_Mutation	novel	E1335*	0.24
SARC	chr9	2158951	Intron	rs568548554		0.48
SARC	chr9	2033023	Missense_Mutation	novel	M99I	0.12
SKCM	chr9	2186140	Silent	NA	A1502A	0.16
SKCM	chr9	2119528	Missense_Mutation	novel	L1252P	0.19
SKCM	chr9	2039611	Silent	NA	P167P	0.84
SKCM	chr9	2084115	Silent	rs753039711	V815V	0.54
SKCM	chr9	2182173	Silent	novel	L1464L	0.83
SKCM	chr9	2088560	Missense_Mutation	NA	P944S	0.42
SKCM	chr9	2081995	Missense_Mutation	NA	S783L	0.59
SKCM	chr9	2096748	Missense_Mutation	NA	S992F	0.12
SKCM	chr9	2110321	Silent	NA	F1120F	0.29
SKCM	chr9	2161844	Silent	NA	P1380P	0.35
SKCM	chr9	2182194	Silent	NA	V1471V	0.1
SKCM	chr9	2056842	Silent	novel	H448H	0.4
SKCM	chr9	2056843	Nonsense_Mutation	novel	Q449*	0.4
SKCM	chr9	2054700	Missense_Mutation	NA	R384W	0.25
SKCM	chr9	2161812	Missense_Mutation	NA	R1370C	0.47
SKCM	chr9	2076235	Missense_Mutation	NA	E648K	0.41
SKCM	chr9	2029125	Missense_Mutation	rs562820489	P35S	0.38
SKCM	chr9	2086993	Silent	NA	F897F	0.62
SKCM	chr9	2181573	Missense_Mutation	NA	S1419L	0.65
SKCM	chr9	2029165	Missense_Mutation	NA	P48L	0.36
SKCM	chr9	2039582	Missense_Mutation	NA	P158S	0.27
SKCM	chr9	2058350	Silent	NA	V469V	0.23
SKCM	chr9	2054680	Missense_Mutation	NA	T377I	0.67
SKCM	chr9	2039706	Missense_Mutation	NA	P199L	0.38
SKCM	chr9	2039602	Missense_Mutation	novel	M164I	0.26
SKCM	chr9	2123808	Silent	NA	I1284I	0.19
SKCM	chr9	2039581	Silent	novel	I157I	0.39
SKCM	chr9	2081880	Missense_Mutation	NA	G745R	0.86
SKCM	chr9	2076262	Missense_Mutation	NA	E657K	0.1
SKCM	chr9	2161877	Silent	rs763381660	I1391I	0.35
SKCM	chr9	2115832	Frame_Shift_Ins	novel	*D1158Pfs49**	0.3
SKCM	chr9	2054700	Missense_Mutation	NA	R384W	0.63
SKCM	chr9	2081846	Missense_Mutation	novel	E733D	0.28
SKCM	chr9	2096660	Missense_Mutation	novel	E963K	0.41
SKCM	chr9	2039611	Silent	NA	P167P	0.08
STAD	chr9	2086916	Missense_Mutation	novel	V872M	0.16
STAD	chr9	2097391	Missense_Mutation	novel	G1000R	0.42
STAD	chr9	2084121	Silent	NA	Q817Q	0.61
STAD	chr9	2123753	Missense_Mutation	NA	R1266Q	0.45
STAD	chr9	2123796	Silent	rs764977538	L1280L	0.19
STAD	chr9	2182188	Silent	novel	K1469K	0.11
STAD	chr9	2076291	Silent	rs765966954	S666S	0.04
STAD	chr9	2123850	Silent	rs141291951	E1298E	0.23
STAD	chr9	2039502	Missense_Mutation	NA	P131Q	0.29
STAD	chr9	2054701	Missense_Mutation	NA	R384Q	0.24
STAD	chr9	2123835	Missense_Mutation	NA	R1293S	0.24
STAD	chr9	2161877	Silent	rs763381660	I1391I	0.37
STAD	chr9	2086906	Missense_Mutation	NA	N868K	0.25
STAD	chr9	2032958	Missense_Mutation	rs762444118	D78N	0.16
STAD	chr9	2056757	Missense_Mutation	novel	R420H	0.39
STAD	chr9	2104047	Missense_Mutation	rs779591664	R1057H	0.17
STAD	chr9	2039604	Missense_Mutation	NA	S165N	0.08
STAD	chr9	2181665	Frame_Shift_Del	novel	I1452*	0.58
STAD	chr9	2086956	Missense_Mutation	novel	Q885R	0.47
STAD	chr9	2110275	Missense_Mutation	NA	R1105H	0.28
STAD	chr9	2060967	Missense_Mutation	NA	K558R	0.08
STAD	chr9	2056835	Missense_Mutation	novel	Q446R	0.16
STAD	chr9	2054682	Missense_Mutation	rs753807887	V378L	0.22
STAD	chr9	2033024	Nonsense_Mutation	novel	R100*	0.31
STAD	chr9	2104016	Missense_Mutation	NA	R1047W	0.21
STAD	chr9	2047441	Nonsense_Mutation	novel	Q335*	0.23
STAD	chr9	2084171	Missense_Mutation	novel	I834T	0.09
STAD	chr9	2039678	Missense_Mutation	NA	K190E	0.34
STAD	chr9	2191331	Missense_Mutation	NA	G1554C	0.39
STAD	chr9	2192784	3'UTR	novel		0.34
STAD	chr9	2161782	Missense_Mutation	novel	D1360N	0.29
STAD	chr9	2161854	Missense_Mutation	NA	T1384A	0.15
STAD	chr9	2073576	Missense_Mutation	novel	A630S	0.25	ResIII
STAD	chr9	2161726	Missense_Mutation	NA	V1341A	0.16
STAD	chr9	2181665	Frame_Shift_Del	novel	I1452*	0.3
STAD	chr9	2058432	Missense_Mutation	NA	R497W	0.26
UCEC	chr9	2029031	Silent	rs775432878	T3T	0.16
UCEC	chr9	2032966	Missense_Mutation	NA	I80M	0.33
UCEC	chr9	2104109	Missense_Mutation	NA	L1078F	0.36
UCEC	chr9	2192726	Missense_Mutation	rs753433101	T1587M	0.32
UCEC	chr9	2054700	Missense_Mutation	NA	R384W	0.29
UCEC	chr9	2058342	Missense_Mutation	NA	R467W	0.26
UCEC	chr9	2158807	Intron	novel		0.21
UCEC	chr9	2056699	Missense_Mutation	novel	R401C	0.2
UCEC	chr9	2161875	Missense_Mutation	NA	I1391V	0.25
UCEC	chr9	2192947	3'UTR	novel		0.26
UCEC	chr9	2039679	Missense_Mutation	novel	K190T	0.31
UCEC	chr9	2193446	3'UTR	novel		0.32
UCEC	chr9	2182180	Missense_Mutation	novel	L1467M	0.25
UCEC	chr9	2192741	3'UTR	novel		0.26
UCEC	chr9	2191298	Frame_Shift_Del	novel	*D1545Mfs22**	0.58
UCEC	chr9	2193353	3'UTR	novel		0.3
UCEC	chr9	2104095	Missense_Mutation	NA	C1073F	0.44
UCEC	chr9	2047439	Missense_Mutation	novel	P334L	0.5
UCEC	chr9	2186125	Silent	novel	S1497S	0.19
UCEC	chr9	2083404	Missense_Mutation	NA	I802M	0.42
UCEC	chr9	2060822	Missense_Mutation	novel	D510N	0.45
UCEC	chr9	2081984	Silent	NA	I779I	0.08
UCEC	chr9	2047444	Missense_Mutation	novel	G336C	0.4
UCEC	chr9	2193370	3'UTR	novel		0.33
UCEC	chr9	2115834	Nonsense_Mutation	novel	Q1157*	0.21
UCEC	chr9	2181646	Silent	novel	I1443I	0.36
UCEC	chr9	2123719	Missense_Mutation	NA	R1255W	0.32
UCEC	chr9	2193306	3'UTR	novel		0.07
UCEC	chr9	2054640	Silent	rs763966056	L364L	0.34
UCEC	chr9	2058342	Missense_Mutation	NA	R467W	0.51
UCEC	chr9	2029101	Missense_Mutation	NA	L27I	0.44
UCEC	chr9	2029198	Missense_Mutation	rs755744610	T59M	0.28
UCEC	chr9	2070463	Missense_Mutation	NA	D580N	0.19
UCEC	chr9	2083367	Frame_Shift_Del	novel	*Y790Lfs11**	0.07
UCEC	chr9	2123927	Missense_Mutation	NA	Q1324R	0.23
UCEC	chr9	2182212	Silent	NA	N1477N	0.36
UCEC	chr9	2056699	Missense_Mutation	novel	R401C	0.17
UCEC	chr9	2186123	Missense_Mutation	novel	S1497P	0.17
UCEC	chr9	2096700	Missense_Mutation	NA	I976S	0.34
UCEC	chr9	2110410	Missense_Mutation	NA	P1150H	0.45
UCEC	chr9	2123821	Missense_Mutation	novel	A1289T	0.21
UCEC	chr9	2161869	Missense_Mutation	rs769712929	A1389T	0.32
UCEC	chr9	2193352	3'UTR	novel		0.48
UCEC	chr9	2054700	Missense_Mutation	NA	R384W	0.3
UCEC	chr9	2123807	Missense_Mutation	novel	I1284T	0.36
UCEC	chr9	2186185	Silent	novel	N1517N	0.38
UCEC	chr9	2193355	3'UTR	novel		0.46
UCEC	chr9	2039877	Missense_Mutation	novel	L256P	0.39
UCEC	chr9	2077747	Silent	novel	L719L	0.29
UCEC	chr9	2083414	Splice_Site	novel	X805_splice	0.33
UCEC	chr9	2182228	Silent	novel	L1483L	0.24
UCEC	chr9	2029198	Missense_Mutation	rs755744610	T59M	0.31
UCEC	chr9	2039592	Missense_Mutation	rs149394378	P161L	0.36
UCEC	chr9	2054648	Silent	novel	G366G	0.32
UCEC	chr9	2104068	Missense_Mutation	rs747313863	A1064V	0.43
UCEC	chr9	2115944	Silent	novel	N1193N	0.2
UCEC	chr9	2123731	Missense_Mutation	novel	D1259N	0.29
UCEC	chr9	2193371	3'UTR	novel		0.34
UCEC	chr9	2029069	Missense_Mutation	novel	S16L	0.19
UCEC	chr9	2191387	Silent	novel	S1572S	0.11
UCEC	chr9	2193169	3'UTR	novel		0.41
UCEC	chr9	2193575	3'UTR	novel		0.26
UCEC	chr9	2104080	Missense_Mutation	novel	R1068Q	0.43
UCEC	chr9	2077724	Missense_Mutation	novel	R711M	0.22
UCEC	chr9	2060957	In_Frame_Ins	NA	K558dup	0.44
UCEC	chr9	2083372	Missense_Mutation	novel	F792V	0.33
UCEC	chr9	2096702	Missense_Mutation	novel	L977M	0.11
UCEC	chr9	2186098	Splice_Region	novel	I1488I	0.46
UCEC	chr9	2104068	Missense_Mutation	rs747313863	A1064V	0.43
UCEC	chr9	2158770	Intron	novel		0.5
UCEC	chr9	2115925	Missense_Mutation	NA	A1187V	0.32
UCEC	chr9	2186134	Silent	NA	K1500K	0.33
UCEC	chr9	2192896	3'UTR	novel		0.27
UCEC	chr9	2076302	Missense_Mutation	novel	S670Y	0.22
UCEC	chr9	2161826	Missense_Mutation	novel	E1374D	0.26
UCEC	chr9	2192978	3'UTR	novel		0.24
UCEC	chr9	2115927	Missense_Mutation	NA	A1188T	0.13
UCEC	chr9	2193371	3'UTR	novel		0.33
UCEC	chr9	2088523	Silent	novel	T931T	0.3
UCEC	chr9	2193586	3'UTR	novel		0.39
UCEC	chr9	2193166	3'UTR	novel		0.23
UCEC	chr9	2029113	Missense_Mutation	novel	P31S	0.65
UCEC	chr9	2058456	Nonsense_Mutation	novel	R505*	0.29
UCEC	chr9	2104068	Missense_Mutation	rs747313863	A1064V	0.15
UCEC	chr9	2193193	3'UTR	novel		0.58
UCEC	chr9	2123895	Silent	rs745662991	D1313D	0.38
UCEC	chr9	2158900	Intron	novel		0.24
UCEC	chr9	2054609	Silent	NA	R353R	0.18
UCEC	chr9	2033045	Missense_Mutation	novel	G107S	0.05
UCEC	chr9	2086961	Missense_Mutation	NA	K887E	0.1
UCEC	chr9	2123881	Missense_Mutation	NA	R1309C	0.82
UCEC	chr9	2193370	3'UTR	novel		0.31
UCEC	chr9	2096739	Missense_Mutation	novel	T989I	0.32
UCEC	chr9	2193140	3'UTR	novel		0.36
UCEC	chr9	2086967	Missense_Mutation	novel	P889T	0.24
UCEC	chr9	2123757	Missense_Mutation	rs763135326	N1267K	0.41
UCEC	chr9	2182209	Silent	novel	H1476H	0.47
UCEC	chr9	2086832	Missense_Mutation	NA	R844W	0.15
UCEC	chr9	2056699	Missense_Mutation	novel	R401C	0.18
UCEC	chr9	2115846	Missense_Mutation	novel	H1161N	0.27
UCEC	chr9	2123867	Missense_Mutation	NA	F1304S	0.44
UCEC	chr9	2170448	Missense_Mutation	novel	S1410Y	0.05
UCEC	chr9	2161822	Missense_Mutation	NA	A1373G	0.58
UCEC	chr9	2029101	Missense_Mutation	NA	L27I	0.21
UCEC	chr9	2058346	Missense_Mutation	NA	S468F	0.3
UCEC	chr9	2192726	Missense_Mutation	rs753433101	T1587M	0.38
UCEC	chr9	2039592	Missense_Mutation	rs149394378	P161L	0.6
UCEC	chr9	2058378	Missense_Mutation	novel	A479S	0.25
UCEC	chr9	2076260	Missense_Mutation	novel	T656I	0.3
UCEC	chr9	2084125	Missense_Mutation	novel	R819W	0.24
UCEC	chr9	2104085	Silent	novel	L1070L	0.23
UCEC	chr9	2110351	Silent	novel	G1130G	0.29
UCEC	chr9	2029101	Missense_Mutation	NA	L27I	0.35
UCEC	chr9	2115978	Missense_Mutation	novel	D1205N	0.52
UCEC	chr9	2123724	Missense_Mutation	novel	M1256I	0.57
UCEC	chr9	2039853	Missense_Mutation	novel	T248M	0.38
UCEC	chr9	2193353	3'UTR	novel		0.32
UCEC	chr9	2056775	Missense_Mutation	NA	A426D	0.25
UCEC	chr9	2161875	Missense_Mutation	NA	I1391V	0.25
UCEC	chr9	2060893	Silent	rs145129640	T533T	0.29
UCEC	chr9	2181578	Nonsense_Mutation	NA	R1421*	0.42
UCEC	chr9	2182220	Missense_Mutation	novel	T1480M	0.4
UCEC	chr9	2161687	Missense_Mutation	NA	A1328V	0.08
UCEC	chr9	2191315	Silent	novel	G1548G	0.77
UCS	chr9	2191349	Nonsense_Mutation	rs747368303	R1560*	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1544	0.073854
LAML	DEL	0.0052	0.24147
OV	DEL	0.4214	0.00059831
SARC	DEL	0.3385	5.1003e-05
TGCT	DEL	0.3867	7.3329e-05
THCA	DEL	0.0301	0.24038
THYM	DEL	0.0325	0.022012

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0002	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.0013	Kaplan-Meier Survival Analysis
ESCA	0.017	Kaplan-Meier Survival Analysis
KIRP	0.019	Kaplan-Meier Survival Analysis
PAAD	0.0051	Kaplan-Meier Survival Analysis
PCPG	0.048	Kaplan-Meier Survival Analysis
CESC	0.032	Kaplan-Meier Survival Analysis
LGG	0.0059	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000080503 (Gene tree)
Gene ID: 6595
Gene Symbol: SMARCA2
Alias: BAF190|hSNF2a|hBRM|Sth1p|SNF2LA|BRM|SNF2|SWI2|SNF2L2
Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 213,335 bases
Position: chr9:1,980,290-2,193,624
Accession: 11098
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349788	ResIII	PF04851.15	8.1e-08	1	1
ENSP00000371629	ResIII	PF04851.15	8.1e-08	1	1
ENSP00000265773	ResIII	PF04851.15	8.2e-08	1	1
ENSP00000371638	ResIII	PF04851.15	8.2e-08	1	1
ENSP00000392081	ResIII	PF04851.15	4.4e-06	1	1
ENSP00000488947	ResIII	PF04851.15	0.00014	1	1
ENSP00000392081	BRK	PF07533.16	9.2e-17	1	1
ENSP00000265773	BRK	PF07533.16	9.4e-17	1	1
ENSP00000371638	BRK	PF07533.16	9.4e-17	1	1
ENSP00000349788	BRK	PF07533.16	9.4e-17	1	1
ENSP00000371629	BRK	PF07533.16	9.4e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18094716	Re-expression of DNA methylation-silenced CD44 gene in a resistant NB4 cell line: rescue of CD44-dependent cell death by cAMP.	Leukemia	2008 Mar	Abecassis I	-
15331701	VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.	J Virol	2004 Sep	Herrera FJ	-
19433513	Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers.	Nucleic Acids Res	2009 Jul	Makkonen H	doi: 10.1093/nar/gkp352
22493065	Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.	Mol Cell Biol	2012 Jun	Tie F	doi: 10.1128/MCB.06392-11

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000634688	SMARCA2-225	897	-	ENSP00000489473	149 (aa)	-	A0A0U1RRD6
ENST00000423555	SMARCA2-212	834	-	ENSP00000413057	228 (aa)	-	F6XE55
ENST00000636969	SMARCA2-256	100	-	-	- (aa)	-	-
ENST00000416751	SMARCA2-210	633	-	ENSP00000412242	192 (aa)	-	F6UH26
ENST00000491574	SMARCA2-217	645	-	-	- (aa)	-	-
ENST00000382183	SMARCA2-205	1178	-	ENSP00000371618	236 (aa)	-	B1ALG1
ENST00000636559	SMARCA2-252	6853	-	ENSP00000490852	279 (aa)	-	A0A1B0GWA8
ENST00000382185	SMARCA2-206	1584	-	ENSP00000371620	276 (aa)	-	B4DNT1
ENST00000635397	SMARCA2-241	578	-	-	- (aa)	-	-
ENST00000382186	SMARCA2-207	955	-	ENSP00000371621	254 (aa)	-	B1ALG2
ENST00000634781	SMARCA2-229	1106	-	ENSP00000489302	260 (aa)	-	A0A0U1RR26
ENST00000635659	SMARCA2-244	762	-	ENSP00000489334	58 (aa)	-	A0A0U1RR45
ENST00000636367	SMARCA2-250	1889	-	ENSP00000489942	98 (aa)	-	A0A0U1RQP3
ENST00000634536	SMARCA2-224	556	-	-	- (aa)	-	-
ENST00000349721	SMARCA2-203	5761	-	ENSP00000265773	1590 (aa)	-	P51531
ENST00000637383	SMARCA2-262	162	-	ENSP00000489645	9 (aa)	-	A0A1B0GTC9
ENST00000635226	SMARCA2-237	640	-	ENSP00000489560	57 (aa)	-	A0A0U1RRJ8
ENST00000634706	SMARCA2-226	630	-	ENSP00000489504	169 (aa)	-	A0A0U1RRF8
ENST00000634925	SMARCA2-230	1582	-	-	- (aa)	-	-
ENST00000637134	SMARCA2-259	100	-	ENSP00000489667	2 (aa)	-	UPI0000061A42
ENST00000357248	SMARCA2-204	5855	-	ENSP00000349788	1572 (aa)	-	P51531
ENST00000636221	SMARCA2-248	100	-	ENSP00000490645	4 (aa)	-	UPI00080A7E98
ENST00000634989	SMARCA2-232	1118	-	ENSP00000489100	98 (aa)	-	A0A0U1RQP3
ENST00000638139	SMARCA2-265	2675	-	-	- (aa)	-	-
ENST00000635739	SMARCA2-246	4272	-	-	- (aa)	-	-
ENST00000637103	SMARCA2-258	5657	-	ENSP00000490486	288 (aa)	-	A0A1B0GU54
ENST00000637856	SMARCA2-264	100	-	-	- (aa)	-	-
ENST00000639760	SMARCA2-266	2942	-	ENSP00000492585	271 (aa)	-	A0A1W2PS06
ENST00000634435	SMARCA2-223	744	-	ENSP00000489212	245 (aa)	-	A0A0U1RQX3
ENST00000634338	SMARCA2-220	740	-	ENSP00000489388	244 (aa)	-	A0A0U1RR83
ENST00000635590	SMARCA2-243	1843	-	ENSP00000489587	98 (aa)	-	A0A0U1RQP3
ENST00000637097	SMARCA2-257	100	-	ENSP00000490411	3 (aa)	-	UPI00000618AB
ENST00000636916	SMARCA2-255	111	-	ENSP00000490262	37 (aa)	-	A0A1B0GUV6
ENST00000635388	SMARCA2-239	711	-	ENSP00000489271	202 (aa)	-	A0A0U1RR09
ENST00000439732	SMARCA2-213	755	-	ENSP00000409398	215 (aa)	-	A0A0A0MT03
ENST00000417599	SMARCA2-211	980	-	ENSP00000387486	276 (aa)	-	B4DNT1
ENST00000382194	SMARCA2-208	5679	-	ENSP00000371629	1572 (aa)	-	P51531
ENST00000635129	SMARCA2-234	582	-	-	- (aa)	-	-
ENST00000635133	SMARCA2-235	758	-	ENSP00000489168	200 (aa)	-	A0A0U1RQU0
ENST00000635392	SMARCA2-240	291	-	ENSP00000489501	38 (aa)	-	A0A0U1RRF5
ENST00000637806	SMARCA2-263	7061	-	ENSP00000490551	279 (aa)	-	A0A1B0GWA8
ENST00000324954	SMARCA2-202	1781	-	ENSP00000324770	248 (aa)	-	F6T8Q0
ENST00000452193	SMARCA2-215	750	-	ENSP00000401096	182 (aa)	-	A0A0A0MSS5
ENST00000634931	SMARCA2-231	939	-	ENSP00000489433	254 (aa)	-	B1ALG2
ENST00000636501	SMARCA2-251	100	-	-	- (aa)	-	-
ENST00000634403	SMARCA2-222	497	-	-	- (aa)	-	-
ENST00000634760	SMARCA2-227	5847	-	ENSP00000489256	1428 (aa)	-	A0A0U1RQZ9
ENST00000635030	SMARCA2-233	571	-	-	- (aa)	-	-
ENST00000636758	SMARCA2-253	100	-	-	- (aa)	-	-
ENST00000636157	SMARCA2-247	3211	-	-	- (aa)	-	-
ENST00000637371	SMARCA2-261	99	-	-	- (aa)	-	-
ENST00000457226	SMARCA2-216	736	-	ENSP00000415218	193 (aa)	-	F6RS74
ENST00000635185	SMARCA2-236	683	-	ENSP00000488947	228 (aa)	-	A0A0U1RQE1
ENST00000637352	SMARCA2-260	128	-	ENSP00000490757	6 (aa)	-	UPI00080A7E56
ENST00000634772	SMARCA2-228	810	-	ENSP00000489518	270 (aa)	-	A0A0U1RRG6
ENST00000636233	SMARCA2-249	100	-	-	- (aa)	-	-
ENST00000635273	SMARCA2-238	672	-	-	- (aa)	-	-
ENST00000635530	SMARCA2-242	712	-	ENSP00000489204	229 (aa)	-	A0A0U1RQW7
ENST00000634271	SMARCA2-218	572	-	-	- (aa)	-	-
ENST00000450198	SMARCA2-214	5602	-	ENSP00000392081	1514 (aa)	-	F6VDE0
ENST00000635688	SMARCA2-245	616	-	ENSP00000489555	68 (aa)	-	A0A0U1RRJ4
ENST00000382203	SMARCA2-209	5867	-	ENSP00000371638	1590 (aa)	-	P51531
ENST00000634343	SMARCA2-221	792	-	ENSP00000489615	231 (aa)	-	A0A0U1RRN2
ENST00000634287	SMARCA2-219	424	-	ENSP00000489142	62 (aa)	-	A0A0U1RQS1
ENST00000636903	SMARCA2-254	2471	-	ENSP00000489968	288 (aa)	-	A0A1B0GU54
ENST00000302401	SMARCA2-201	2242	-	ENSP00000305411	278 (aa)	-	B1ALF6

Gene Model

Click here to download ENSG00000080503's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04714	Thermogenesis	KEGG
hsa05225	Hepatocellular carcinoma	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000080503	Thyrotropin	1.10420769167536E-6	17903292
ENSG00000080503	Thyrotropin	8.67406199885528E-6	17903292
ENSG00000080503	Electrocardiography	1.23538421617179E-8	17903306
ENSG00000080503	Angiography	4.88629715162291E-5	17903301
ENSG00000080503	Hand Strength	6.23712966631719E-8	17903295
ENSG00000080503	Hand Strength	5.93760790749435E-8	17903295
ENSG00000080503	Myocardial Infarction	6.2666607E-004	-
ENSG00000080503	Stroke	9.3877195E-004	-
ENSG00000080503	Respiratory Function Tests	9.0520000E-005	-
ENSG00000080503	Body Fat Distribution	6.5200000E-005	-
ENSG00000080503	Arteries	1.9840000E-005	-
ENSG00000080503	Erythrocyte Count	3.8410000E-005	-
ENSG00000080503	Platelet Function Tests	7.7100000E-006	-
ENSG00000080503	Platelet Function Tests	2.4300000E-007	-
ENSG00000080503	Platelet Function Tests	5.3700000E-007	-
ENSG00000080503	Platelet Function Tests	2.1300000E-006	-
ENSG00000080503	Platelet Function Tests	9.0400000E-006	-
ENSG00000080503	Platelet Function Tests	5.7200000E-007	-
ENSG00000080503	Platelet Function Tests	2.7800000E-006	-
ENSG00000080503	Platelet Function Tests	9.1000000E-006	-
ENSG00000080503	Platelet Function Tests	3.0600000E-007	-
ENSG00000080503	Platelet Function Tests	6.6300000E-007	-
ENSG00000080503	Magnesium	2.4280000E-005	-
ENSG00000080503	Erythropoietin	7.2980000E-005	-
ENSG00000080503	Attention Deficit Disorder with Hyperactivity	7E-6	23453885
ENSG00000080503	Bipolar Disorder	7E-6	23453885
ENSG00000080503	Child Development Disorders, Pervasive	7E-6	23453885
ENSG00000080503	Depressive Disorder	7E-6	23453885
ENSG00000080503	Schizophrenia	7E-6	23453885
ENSG00000080503	Alopecia	2E-6	24025145
ENSG00000080503	Cyclophosphamide	2E-6	24025145
ENSG00000080503	Doxorubicin	2E-6	24025145
ENSG00000080503	Fluorouracil	2E-6	24025145
ENSG00000080503	Amyotrophic lateral sclerosis 1	1E-6	24529757
ENSG00000080503	Anticoagulants	4E-6	26265036
ENSG00000080503	Attention Deficit Disorder with Hyperactivity	9E-7	27890468
ENSG00000080503	Bipolar Disorder	9E-7	27890468

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000080503	rs10811256	9	1995749	?	Asthma (childhood onset)	27611488	[0.11-0.28] unit decrease	0.198	EFO_0000270
ENSG00000080503	rs10511434	9	2114024	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000080503's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000080503	SMARCA2	99	98.000	ENSG00000127616	SMARCA4	99	90.202
ENSG00000080503	SMARCA2	74	65.714	ENSG00000173575	CHD2	89	62.376
ENSG00000080503	SMARCA2	78	37.912	ENSG00000119969	HELLS	67	47.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000080503	SMARCA2	99	98.000	ENSAPOG00000002641	SMARCA2	97	80.284	Acanthochromis_polyacanthus
ENSG00000080503	SMARCA2	99	100.000	ENSAMEG00000012325	SMARCA2	100	99.218	Ailuropoda_melanoleuca
ENSG00000080503	SMARCA2	97	95.238	ENSACIG00000015607	SMARCA2	97	79.743	Amphilophus_citrinellus
ENSG00000080503	SMARCA2	99	98.000	ENSAOCG00000009647	-	97	78.767	Amphiprion_ocellaris
ENSG00000080503	SMARCA2	99	98.000	ENSAPEG00000007646	SMARCA2	97	78.803	Amphiprion_percula
ENSG00000080503	SMARCA2	99	98.000	ENSATEG00000006916	SMARCA2	96	81.429	Anabas_testudineus
ENSG00000080503	SMARCA2	99	98.000	ENSAPLG00000013873	SMARCA2	95	89.536	Anas_platyrhynchos
ENSG00000080503	SMARCA2	100	95.973	ENSACAG00000002423	SMARCA2	100	89.765	Anolis_carolinensis
ENSG00000080503	SMARCA2	100	100.000	ENSANAG00000026498	SMARCA2	100	99.119	Aotus_nancymaae
ENSG00000080503	SMARCA2	99	98.000	ENSACLG00000004248	SMARCA2	97	80.518	Astatotilapia_calliptera
ENSG00000080503	SMARCA2	99	98.000	ENSAMXG00000012404	smarca2	97	82.414	Astyanax_mexicanus
ENSG00000080503	SMARCA2	100	100.000	ENSBTAG00000007494	SMARCA2	100	97.201	Bos_taurus
ENSG00000080503	SMARCA2	100	100.000	ENSCJAG00000010710	SMARCA2	99	99.144	Callithrix_jacchus
ENSG00000080503	SMARCA2	100	100.000	ENSCAFG00000002013	SMARCA2	100	97.774	Canis_familiaris
ENSG00000080503	SMARCA2	100	100.000	ENSCAFG00020026802	SMARCA2	98	94.906	Canis_lupus_dingo
ENSG00000080503	SMARCA2	100	100.000	ENSCHIG00000025863	SMARCA2	100	97.233	Capra_hircus
ENSG00000080503	SMARCA2	100	100.000	ENSTSYG00000003858	SMARCA2	100	98.054	Carlito_syrichta
ENSG00000080503	SMARCA2	100	100.000	ENSCAPG00000002890	SMARCA2	99	93.287	Cavia_aperea
ENSG00000080503	SMARCA2	100	100.000	ENSCPOG00000005475	SMARCA2	100	97.203	Cavia_porcellus
ENSG00000080503	SMARCA2	100	100.000	ENSCCAG00000030636	SMARCA2	100	99.300	Cebus_capucinus
ENSG00000080503	SMARCA2	100	100.000	ENSCATG00000031470	SMARCA2	100	98.856	Cercocebus_atys
ENSG00000080503	SMARCA2	100	99.329	ENSCLAG00000014484	SMARCA2	100	97.462	Chinchilla_lanigera
ENSG00000080503	SMARCA2	100	100.000	ENSCSAG00000008650	SMARCA2	99	98.844	Chlorocebus_sabaeus
ENSG00000080503	SMARCA2	99	100.000	ENSCHOG00000004316	SMARCA2	87	93.333	Choloepus_hoffmanni
ENSG00000080503	SMARCA2	100	98.000	ENSCPBG00000025463	SMARCA2	100	95.115	Chrysemys_picta_bellii
ENSG00000080503	SMARCA2	100	100.000	ENSCANG00000039597	SMARCA2	100	99.245	Colobus_angolensis_palliatus
ENSG00000080503	SMARCA2	100	98.658	ENSCGRG00001002323	Smarca2	100	89.579	Cricetulus_griseus_chok1gshd
ENSG00000080503	SMARCA2	95	97.222	ENSCSEG00000019311	SMARCA2	96	77.590	Cynoglossus_semilaevis
ENSG00000080503	SMARCA2	99	98.000	ENSCVAG00000016571	SMARCA2	75	86.346	Cyprinodon_variegatus
ENSG00000080503	SMARCA2	99	98.000	ENSDARG00000008904	smarca2	97	81.707	Danio_rerio
ENSG00000080503	SMARCA2	100	99.329	ENSDNOG00000006402	SMARCA2	100	96.226	Dasypus_novemcinctus
ENSG00000080503	SMARCA2	100	99.408	ENSDORG00000014832	Smarca2	100	97.550	Dipodomys_ordii
ENSG00000080503	SMARCA2	97	92.000	FBgn0000212	brm	71	56.866	Drosophila_melanogaster
ENSG00000080503	SMARCA2	93	100.000	ENSEBUG00000011442	-	96	69.649	Eptatretus_burgeri
ENSG00000080503	SMARCA2	99	90.476	ENSEBUG00000002449	-	89	68.548	Eptatretus_burgeri
ENSG00000080503	SMARCA2	100	100.000	ENSEASG00005010312	SMARCA2	100	97.333	Equus_asinus_asinus
ENSG00000080503	SMARCA2	99	98.507	ENSEEUG00000015540	-	69	98.611	Erinaceus_europaeus
ENSG00000080503	SMARCA2	99	98.000	ENSELUG00000010318	smarca2	96	79.236	Esox_lucius
ENSG00000080503	SMARCA2	100	100.000	ENSFCAG00000001568	SMARCA2	100	97.201	Felis_catus
ENSG00000080503	SMARCA2	100	97.987	ENSFALG00000010416	SMARCA2	100	92.760	Ficedula_albicollis
ENSG00000080503	SMARCA2	100	99.329	ENSFDAG00000010502	SMARCA2	99	95.833	Fukomys_damarensis
ENSG00000080503	SMARCA2	99	98.000	ENSFHEG00000021250	SMARCA2	97	80.319	Fundulus_heteroclitus
ENSG00000080503	SMARCA2	99	96.000	ENSGMOG00000014229	SMARCA2	97	77.461	Gadus_morhua
ENSG00000080503	SMARCA2	100	98.500	ENSGALG00000010164	SMARCA2	100	91.863	Gallus_gallus
ENSG00000080503	SMARCA2	99	98.000	ENSGAFG00000001164	SMARCA2	93	76.443	Gambusia_affinis
ENSG00000080503	SMARCA2	99	96.000	ENSGACG00000014488	SMARCA2	97	78.618	Gasterosteus_aculeatus
ENSG00000080503	SMARCA2	100	97.987	ENSGAGG00000024412	SMARCA2	100	91.926	Gopherus_agassizii
ENSG00000080503	SMARCA2	100	100.000	ENSGGOG00000000513	SMARCA2	100	89.122	Gorilla_gorilla
ENSG00000080503	SMARCA2	99	98.000	ENSHBUG00000006691	SMARCA2	95	80.534	Haplochromis_burtoni
ENSG00000080503	SMARCA2	100	100.000	ENSHGLG00000005215	SMARCA2	99	96.831	Heterocephalus_glaber_female
ENSG00000080503	SMARCA2	100	100.000	ENSHGLG00100010496	SMARCA2	100	95.931	Heterocephalus_glaber_male
ENSG00000080503	SMARCA2	93	98.000	ENSHCOG00000015348	-	88	86.733	Hippocampus_comes
ENSG00000080503	SMARCA2	99	98.000	ENSIPUG00000011060	smarca2	97	80.242	Ictalurus_punctatus
ENSG00000080503	SMARCA2	100	99.329	ENSSTOG00000006812	SMARCA2	100	98.116	Ictidomys_tridecemlineatus
ENSG00000080503	SMARCA2	100	99.408	ENSJJAG00000010867	Smarca2	100	97.586	Jaculus_jaculus
ENSG00000080503	SMARCA2	99	98.000	ENSKMAG00000015844	-	98	79.987	Kryptolebias_marmoratus
ENSG00000080503	SMARCA2	100	82.870	ENSLACG00000000270	SMARCA2	57	87.002	Latimeria_chalumnae
ENSG00000080503	SMARCA2	99	98.000	ENSLOCG00000011499	smarca2	97	83.429	Lepisosteus_oculatus
ENSG00000080503	SMARCA2	100	99.329	ENSLAFG00000014061	SMARCA2	83	98.018	Loxodonta_africana
ENSG00000080503	SMARCA2	100	100.000	ENSMFAG00000003814	SMARCA2	100	97.673	Macaca_fascicularis
ENSG00000080503	SMARCA2	100	100.000	ENSMMUG00000015279	SMARCA2	100	99.308	Macaca_mulatta
ENSG00000080503	SMARCA2	100	100.000	ENSMNEG00000041069	SMARCA2	100	98.681	Macaca_nemestrina
ENSG00000080503	SMARCA2	100	100.000	ENSMLEG00000027418	SMARCA2	100	96.478	Mandrillus_leucophaeus
ENSG00000080503	SMARCA2	99	98.000	ENSMAMG00000003056	SMARCA2	97	82.117	Mastacembelus_armatus
ENSG00000080503	SMARCA2	99	98.000	ENSMZEG00005020709	SMARCA2	97	80.670	Maylandia_zebra
ENSG00000080503	SMARCA2	100	91.192	ENSMGAG00000005160	-	100	77.822	Meleagris_gallopavo
ENSG00000080503	SMARCA2	100	99.408	ENSMICG00000005162	SMARCA2	100	98.176	Microcebus_murinus
ENSG00000080503	SMARCA2	100	98.658	ENSMOCG00000001611	Smarca2	100	97.206	Microtus_ochrogaster
ENSG00000080503	SMARCA2	95	97.222	ENSMMOG00000014196	SMARCA2	97	79.216	Mola_mola
ENSG00000080503	SMARCA2	99	99.441	ENSMODG00000003578	SMARCA2	100	94.211	Monodelphis_domestica
ENSG00000080503	SMARCA2	99	98.000	ENSMALG00000009611	SMARCA2	97	80.772	Monopterus_albus
ENSG00000080503	SMARCA2	100	99.329	MGP_CAROLIEiJ_G0022841	Smarca2	100	96.861	Mus_caroli
ENSG00000080503	SMARCA2	99	100.000	ENSMUSG00000024921	Smarca2	99	100.000	Mus_musculus
ENSG00000080503	SMARCA2	100	99.329	MGP_PahariEiJ_G0014334	Smarca2	100	97.150	Mus_pahari
ENSG00000080503	SMARCA2	100	98.658	MGP_SPRETEiJ_G0023759	Smarca2	99	98.152	Mus_spretus
ENSG00000080503	SMARCA2	99	100.000	ENSMPUG00000005171	SMARCA2	94	99.219	Mustela_putorius_furo
ENSG00000080503	SMARCA2	100	100.000	ENSMLUG00000002342	SMARCA2	99	90.391	Myotis_lucifugus
ENSG00000080503	SMARCA2	99	98.901	ENSNGAG00000000108	Smarca2	99	96.103	Nannospalax_galili
ENSG00000080503	SMARCA2	93	98.000	ENSNBRG00000017998	SMARCA2	94	83.085	Neolamprologus_brichardi
ENSG00000080503	SMARCA2	100	100.000	ENSNLEG00000008575	SMARCA2	100	95.802	Nomascus_leucogenys
ENSG00000080503	SMARCA2	98	100.000	ENSMEUG00000009812	SMARCA2	100	85.660	Notamacropus_eugenii
ENSG00000080503	SMARCA2	100	98.658	ENSOPRG00000013474	SMARCA2	94	98.200	Ochotona_princeps
ENSG00000080503	SMARCA2	100	99.329	ENSODEG00000005452	SMARCA2	99	96.350	Octodon_degus
ENSG00000080503	SMARCA2	99	98.000	ENSONIG00000014163	SMARCA2	78	87.281	Oreochromis_niloticus
ENSG00000080503	SMARCA2	99	98.000	ENSOANG00000008299	-	95	98.248	Ornithorhynchus_anatinus
ENSG00000080503	SMARCA2	100	100.000	ENSOCUG00000006320	SMARCA2	100	97.090	Oryctolagus_cuniculus
ENSG00000080503	SMARCA2	99	98.000	ENSORLG00000020820	SMARCA2	100	78.403	Oryzias_latipes
ENSG00000080503	SMARCA2	99	98.000	ENSORLG00015006289	SMARCA2	100	78.403	Oryzias_latipes_hsok
ENSG00000080503	SMARCA2	99	98.000	ENSOMEG00000009736	-	97	80.013	Oryzias_melastigma
ENSG00000080503	SMARCA2	100	99.408	ENSOGAG00000017053	SMARCA2	99	94.312	Otolemur_garnettii
ENSG00000080503	SMARCA2	99	100.000	ENSOARG00000013265	SMARCA2	100	95.492	Ovis_aries
ENSG00000080503	SMARCA2	100	100.000	ENSPPAG00000038717	SMARCA2	100	95.990	Pan_paniscus
ENSG00000080503	SMARCA2	100	100.000	ENSPPRG00000001879	SMARCA2	100	97.265	Panthera_pardus
ENSG00000080503	SMARCA2	100	100.000	ENSPTRG00000051168	SMARCA2	100	97.425	Pan_troglodytes
ENSG00000080503	SMARCA2	100	100.000	ENSPANG00000025121	SMARCA2	100	91.724	Papio_anubis
ENSG00000080503	SMARCA2	99	98.000	ENSPKIG00000018469	-	100	82.390	Paramormyrops_kingsleyae
ENSG00000080503	SMARCA2	99	98.889	ENSPSIG00000006284	SMARCA2	100	91.238	Pelodiscus_sinensis
ENSG00000080503	SMARCA2	95	94.444	ENSPMGG00000013696	-	97	74.870	Periophthalmus_magnuspinnatus
ENSG00000080503	SMARCA2	100	99.329	ENSPEMG00000019821	Smarca2	100	96.673	Peromyscus_maniculatus_bairdii
ENSG00000080503	SMARCA2	99	100.000	ENSPMAG00000005337	-	94	72.548	Petromyzon_marinus
ENSG00000080503	SMARCA2	99	98.000	ENSPMAG00000001030	-	100	81.399	Petromyzon_marinus
ENSG00000080503	SMARCA2	99	99.441	ENSPCIG00000015658	SMARCA2	100	94.402	Phascolarctos_cinereus
ENSG00000080503	SMARCA2	99	98.000	ENSPFOG00000001856	SMARCA2	97	79.159	Poecilia_formosa
ENSG00000080503	SMARCA2	99	98.000	ENSPLAG00000017829	SMARCA2	96	77.505	Poecilia_latipinna
ENSG00000080503	SMARCA2	99	98.000	ENSPMEG00000001815	-	97	76.240	Poecilia_mexicana
ENSG00000080503	SMARCA2	99	98.000	ENSPREG00000013800	SMARCA2	96	77.337	Poecilia_reticulata
ENSG00000080503	SMARCA2	100	99.482	ENSPPYG00000019258	SMARCA2	100	98.791	Pongo_abelii
ENSG00000080503	SMARCA2	98	96.721	ENSPCAG00000016969	SMARCA2	78	86.973	Procavia_capensis
ENSG00000080503	SMARCA2	100	99.408	ENSPCOG00000025709	SMARCA2	100	96.354	Propithecus_coquereli
ENSG00000080503	SMARCA2	99	99.441	ENSPVAG00000000901	SMARCA2	95	98.421	Pteropus_vampyrus
ENSG00000080503	SMARCA2	99	98.000	ENSPNYG00000004533	SMARCA2	97	76.918	Pundamilia_nyererei
ENSG00000080503	SMARCA2	99	98.000	ENSPNAG00000014635	smarca2	96	82.803	Pygocentrus_nattereri
ENSG00000080503	SMARCA2	99	99.441	ENSRNOG00000011931	Smarca2	100	96.681	Rattus_norvegicus
ENSG00000080503	SMARCA2	100	100.000	ENSRBIG00000038618	SMARCA2	100	96.819	Rhinopithecus_bieti
ENSG00000080503	SMARCA2	100	100.000	ENSRROG00000019271	SMARCA2	100	97.987	Rhinopithecus_roxellana
ENSG00000080503	SMARCA2	100	100.000	ENSSBOG00000034827	SMARCA2	100	95.196	Saimiri_boliviensis_boliviensis
ENSG00000080503	SMARCA2	99	99.441	ENSSHAG00000007884	SMARCA2	100	93.702	Sarcophilus_harrisii
ENSG00000080503	SMARCA2	99	98.000	ENSSFOG00015014870	SMARCA2	97	85.510	Scleropages_formosus
ENSG00000080503	SMARCA2	99	98.000	ENSSMAG00000013707	SMARCA2	98	79.682	Scophthalmus_maximus
ENSG00000080503	SMARCA2	99	98.000	ENSSDUG00000008852	-	96	80.844	Seriola_dumerili
ENSG00000080503	SMARCA2	97	95.238	ENSSLDG00000025449	SMARCA2	96	80.597	Seriola_lalandi_dorsalis
ENSG00000080503	SMARCA2	99	98.000	ENSSARG00000007888	SMARCA2	95	96.842	Sorex_araneus
ENSG00000080503	SMARCA2	99	98.000	ENSSPUG00000001629	SMARCA2	98	85.836	Sphenodon_punctatus
ENSG00000080503	SMARCA2	99	98.000	ENSSPAG00000020091	-	97	80.077	Stegastes_partitus
ENSG00000080503	SMARCA2	100	100.000	ENSSSCG00000005232	SMARCA2	100	97.296	Sus_scrofa
ENSG00000080503	SMARCA2	100	97.987	ENSTGUG00000005460	SMARCA2	100	90.273	Taeniopygia_guttata
ENSG00000080503	SMARCA2	97	95.238	ENSTRUG00000015619	SMARCA2	97	79.949	Takifugu_rubripes
ENSG00000080503	SMARCA2	99	99.441	ENSTBEG00000008767	SMARCA2	74	100.000	Tupaia_belangeri
ENSG00000080503	SMARCA2	99	99.441	ENSTTRG00000002033	SMARCA2	100	93.648	Tursiops_truncatus
ENSG00000080503	SMARCA2	99	100.000	ENSUAMG00000024701	SMARCA2	99	95.150	Ursus_americanus
ENSG00000080503	SMARCA2	99	100.000	ENSVPAG00000001204	SMARCA2	100	87.620	Vicugna_pacos
ENSG00000080503	SMARCA2	100	100.000	ENSVVUG00000004598	SMARCA2	99	95.913	Vulpes_vulpes
ENSG00000080503	SMARCA2	100	92.617	ENSXETG00000015299	smarca2	82	87.557	Xenopus_tropicalis
ENSG00000080503	SMARCA2	99	98.000	ENSXCOG00000011073	SMARCA2	97	79.335	Xiphophorus_couchianus
ENSG00000080503	SMARCA2	99	98.000	ENSXMAG00000015611	SMARCA2	95	78.631	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	17938176.	TAS	Process
GO:0000790	nuclear chromatin	12065415.	IDA	Component
GO:0003682	chromatin binding	-	IEA	Function
GO:0003713	transcription coactivator activity	17984088.	IDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	12065415.12200431.15107404.15696166.16341228.16601680.17984088.20111005.25910212.26787460.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	17984088.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006338	chromatin remodeling	22368283.	IMP	Process
GO:0006338	chromatin remodeling	17938176.	TAS	Process
GO:0006355	regulation of transcription, DNA-templated	8670841.	TAS	Process
GO:0006357	regulation of transcription by RNA polymerase II	8223438.	TAS	Process
GO:0007286	spermatid development	-	IEA	Process
GO:0007399	nervous system development	-	IEA	Process
GO:0008094	DNA-dependent ATPase activity	17938176.	TAS	Function
GO:0008285	negative regulation of cell proliferation	14660596.	IDA	Process
GO:0016514	SWI/SNF complex	11078522.	IDA	Component
GO:0030308	negative regulation of cell growth	12065415.	IMP	Process
GO:0042393	histone binding	-	IEA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0044212	transcription regulatory region DNA binding	17984088.	IDA	Function
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0045892	negative regulation of transcription, DNA-templated	12065415.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	17984088.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	8208605.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	15774904.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	17938176.	TAS	Process
GO:0071564	npBAF complex	-	ISS	Component
GO:0071565	nBAF complex	-	ISS	Component

EuRBPDB

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Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.