EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19177010Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.Cell Cycle2009 Feb 1Pucci S-
25818292Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.Cell Rep2015 Mar 31Cook Rdoi: 10.1016/j.celrep.2015.02.059
24271118Expression of Ku86 and presence of Ku86 antibody as biomarkers of hepatitis B virus related hepatocellular carcinoma.Dig Dis Sci2014 MarXu Ydoi: 10.1007/s10620-013-2941-1
12403924Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration.Intervirology2002Liu X-
22226916Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway.Carcinogenesis2012 MarWei Sdoi: 10.1093/carcin/bgr319
24615008Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer.Med Oncol2014 AprRajaei Mdoi: 10.1007/s12032-014-0885-8
17904587A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer.Mutat Res2008 Feb 1Wang S-
21877955Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.Genet Test Mol Biomarkers2012 FebAl-Hadyan KSdoi: 10.1089/gtmb.2011.0126
23098447Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.Asian Pac J Cancer Prev2012Zhou LP-
17982634Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.Oncol Rep2007 DecSomeya M-
19906305Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.Breast Cancer Res2009Nolens Gdoi: 10.1186/bcr2450
20811692The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk.Oncol Rep2010 OctGomes BC-
19414375Significant association of Ku80 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan.Anticancer Res2009 AprChang CH-
23788213Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.Epidemiology2013 SepLong XDdoi: 10.1097/EDE.0b013e31829d2744.
19205005Glucose deprivation increases nuclear DNA repair protein Ku and resistance to radiation induced oxidative stress in human cancer cells.Cell Biochem Funct2009 MarLi Jdoi: 10.1002/cbf.1541.
21547134Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer.World J Gastroenterol2011 Apr 28Li JQdoi: 10.3748/wjg.v17.i16.2131.
25527410Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5.Pathol Oncol Res2015 JulSaadat Mdoi: 10.1007/s12253-014-9875-6
19528488Significant association of Ku80 single nucleotide polymorphisms with colorectal cancer susceptibility in Central Taiwan.Anticancer Res2009 JunYang MD-
21137076Ku86 is important for TrkA overexpression-induced breast cancer cell invasion.Proteomics Clin Appl2010 JulLagadec Cdoi: 10.1002/prca.200900148
20044645Significant association of DNA repair gene Ku80 genotypes with breast cancer susceptibility in Taiwan.Anticancer Res2009 DecWang HC-
17671430Bin1 interacts with and restrains the DNA end-binding protein complex Ku.Cell Cycle2007 Aug 1Ramalingam A-
26358256Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.Tumour Biol2016 FebChen Jdoi: 10.1007/s13277-015-4048-0
26867665Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy.Med Mol Morphol2016 DecTakada Y-
29049411XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.PLoS One2017 Oct 19Zhang Zdoi: 10.1371/journal.pone.0186900

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2216127589Frame_Shift_DelNAE287Kfs*110.13
BLCAchr2216119100Silentrs376163776F142F0.61
BLCAchr2216127587Frame_Shift_InsnovelL284Qfs*110.07
BLCAchr2216127566Missense_MutationNAT277A0.19
BRCAchr2216116832Silentrs768296550Q103Q0.07
BRCAchr2216122120Missense_Mutationrs764110781R184C0.12
BRCAchr2216127589Frame_Shift_DelNAE287Kfs*110.33
CESCchr22161093635'UTRnovel0.32
CESCchr22162053833'UTRnovel0.23
CESCchr2216122244Missense_MutationnovelY225F0.71
CESCchr2216138151SilentNAL438L0.5
COADchr2216141186Missense_MutationNAE448V0.39
COADchr2216113125Missense_MutationnovelR44Q0.28
COADchr2216190251Missense_Mutationrs762387474E621K0.29
COADchr2216125994Missense_MutationNAG254D0.4
COADchr2216127589Frame_Shift_DelNAE287Kfs*110.21
COADchr2216119096Missense_MutationnovelR141Q0.13
COADchr2216148111Missense_Mutationrs548351594R502Q0.43
COADchr2216132358SilentNAL362L0.09
COADchr2216148110Missense_MutationNAR502W0.42
COADchr2216122202Missense_MutationnovelV211A0.35
COADchr2216130930Missense_MutationNAM331I0.24
COADchr2216148249Missense_Mutationrs376814697V548A0.08
COADchr2216190251Missense_Mutationrs762387474E621K0.56
COADchr2216204391Missense_Mutationrs772117253D727N0.3
COADchr2216204389Missense_MutationNAD726G0.31
COADchr2216130984SilentnovelS349S0.32
COADchr2216141305Frame_Shift_DelnovelQ488Rfs*290.06
COADchr2216127589Frame_Shift_DelNAE287Kfs*110.29
COADchr2216116697SilentnovelL58L0.32
DLBCchr2216119139Missense_MutationnovelK155N0.44
DLBCchr2216141197Missense_MutationnovelN452D0.77
ESCAchr22161093165'UTRnovel0.35
GBMchr2216148122Missense_MutationnovelP506A0.08
GBMchr2216161986Missense_MutationnovelS591T0.13
GBMchr22162052513'UTRnovel0.15
GBMchr2216116712SilentnovelG63G0.52
GBMchr22162053333'UTRnovel0.21
GBMchr2216130941Missense_MutationNAS335L0.24
GBMchr2216137195SilentnovelV407V0.05
HNSCchr2216122207Missense_MutationnovelI213V0.22
HNSCchr2216117725Intronnovel0.31
HNSCchr22162052713'UTRnovel0.1
HNSCchr2216137214Missense_MutationnovelH414Y0.16
HNSCchr2216127579Frame_Shift_InsnovelT283Nfs*170.29
HNSCchr2216138121Missense_MutationnovelE428D0.41
KIRCchr2216141188Missense_Mutationrs772908780A449T0.2
KIRCchr2216122143Frame_Shift_DelnovelF192Sfs*80.15
KIRCchr2216137115Missense_MutationNAI381L0.17
KIRPchr2216116840Frame_Shift_InsnovelF107Lfs*150.36
KIRPchr2216117748Missense_MutationnovelL108M0.28
LGGchr2216113038Missense_MutationnovelD15G0.43
LGGchr2216205197Missense_MutationnovelI732V0.42
LIHCchr2216113022Missense_MutationnovelV10I0.22
LIHCchr2216141281Missense_MutationnovelT480A0.32
LUADchr2216130884Missense_MutationNAY316C0.39
LUADchr2216125941SilentNAV236V0.06
LUADchr2216117693Intronnovel0.15
LUADchr2216192718Nonsense_MutationnovelW675*0.56
LUADchr2216116710Missense_MutationNAG63C0.28
LUADchr2216125973Missense_MutationnovelW247L0.19
LUADchr2216204344Missense_MutationNAP711R0.19
LUADchr2216192655Missense_MutationnovelR654L0.29
LUADchr2216132345Missense_MutationNAM357I0.16
LUADchr2216119065Missense_MutationNAH131Y0.08
LUADchr2216148131Nonsense_MutationNAQ509*0.36
LUSCchr2216127674Missense_MutationnovelG313R0.2
LUSCchr2216161990SilentnovelV592V0.4
LUSCchr2216141267Missense_MutationnovelD475G0.29
LUSCchr2216116775Missense_MutationNAM84I0.34
LUSCchr2216119066Missense_MutationNAH131P0.3
LUSCchr22161093515'UTRnovel1
LUSCchr22161093575'UTRnovel0.29
LUSCchr2216194920In_Frame_DelnovelD681_L685delinsE0.24
OVchr2216190280Silentrs368212132P630P0.04
OVchr22161094015'UTRnovel0.04
OVchr2216138122Nonsense_MutationnovelD429delinsVSLFLG*RY0.05
PAADchr2216113101Missense_MutationnovelK36R0.17
PAADchr2216138119Missense_MutationnovelE428K0.15
PCPGchr2216122187Missense_MutationnovelE206V0.08
PRADchr2216117692Intronnovel0.57
READchr2216125939Missense_Mutationrs760212422V236I0.14
READchr2216204391Missense_Mutationrs772117253D727N0.32
READchr2216161986Missense_MutationnovelS591N0.39
READchr2216138122Missense_MutationnovelD429N0.23
READchr2216127566Missense_MutationNAT277P0.24
SKCMchr2216190313SilentnovelA641A0.17
SKCMchr2216137112SilentNAL380L0.34
SKCMchr2216148154SilentnovelL516L0.24
SKCMchr2216138174Missense_MutationNAP446L0.23
SKCMchr22162053443'UTRnovel0.57
SKCMchr2216148109SilentNAP501P0.2
SKCMchr2216141290Missense_MutationNAP483S0.26
STADchr2216127625Missense_MutationnovelC296W0.13
STADchr2216127589Frame_Shift_DelNAE287Kfs*110.2
STADchr22162052063'UTRrs7797804890.31
STADchr2216116897Intronnovel0.34
STADchr22161094335'UTRnovel0.15
STADchr2216116832Silentrs768296550Q103Q0.24
STADchr2216148164Missense_Mutationrs761811665A520T0.14
STADchr2216132352Nonsense_MutationNAQ360*0.28
STADchr2216137161Missense_MutationNAA396V0.1
STADchr2216127628Frame_Shift_DelnovelN298Mfs*90.32
STADchr2216204352Missense_MutationNAD714N0.3
STADchr2216122165Missense_MutationNAE199K0.23
STADchr2216127588Missense_MutationNAL284Q0.09
STADchr2216160090Frame_Shift_DelnovelK566Nfs*20.13
STADchr22162053333'UTRnovel0.26
THCAchr2216127644In_Frame_InsnovelT303delinsNLIHS0.12
THCAchr2216113019Missense_MutationNAA9T0.39
THCAchr2216127587Frame_Shift_InsnovelL284Qfs*230.12
UCECchr2216204358Missense_MutationNAA716S0.05
UCECchr22162052563'UTRnovel0.29
UCECchr2216117750SilentnovelL108L0.57
UCECchr2216122165Missense_MutationNAE199K0.31
UCECchr2216204391Missense_Mutationrs772117253D727N0.31
UCECchr22162053073'UTRnovel0.39
UCECchr2216204362Missense_MutationnovelA717D0.29
UCECchr2216125939Missense_Mutationrs760212422V236I0.37
UCECchr2216122127Missense_MutationnovelG186D0.45
UCECchr2216127611Nonsense_MutationnovelE292*0.3
UCECchr22162053703'UTRnovel0.09
UCECchr2216160096Missense_MutationnovelL567I0.48
UCECchr2216125939Missense_Mutationrs760212422V236I0.14
UCECchr2216116823Silentrs755967499P100P0.2
UCECchr2216141185Splice_SitenovelX448_splice0.18
UCECchr2216127589Frame_Shift_DelNAE287Kfs*110.28
UCECchr2216190336Splice_SiteNAX648_splice0.45
UCECchr2216148084Missense_MutationnovelC493Y0.41
UCECchr2216141294Missense_MutationnovelN484T0.47
UCECchr2216190251Missense_Mutationrs762387474E621K0.41
UCECchr2216127589Frame_Shift_DelNAE287Kfs*110.41
UCECchr2216122067Missense_MutationnovelP166H0.55
UCECchr22162052353'UTRnovel0.45
UCECchr22162052403'UTRrs7471211750.99
UCECchr2216190251Missense_Mutationrs762387474E621K0.31
UCECchr2216113039Silentrs769816648D15D0.48
UCECchr2216116952Intronnovel0.25
UCECchr2216190251Missense_Mutationrs762387474E621K0.4
UCECchr2216117773Missense_MutationnovelD116G0.33
UCECchr22161076755'Flanknovel0.23
UCECchr2216137154Nonsense_MutationnovelR394*0.35
UCECchr2216122159Missense_MutationnovelI197L0.13
UCECchr2216113125Missense_MutationnovelR44Q0.48
UCECchr2216126027Missense_MutationnovelK265T0.28
UCECchr2216192690Missense_MutationnovelV666L0.3
UCECchr2216204338Missense_MutationnovelD709G0.25
UCECchr22162052053'UTRnovel0.45
UCECchr2216116765Missense_MutationnovelR81I0.24
UCECchr2216122156Nonsense_MutationnovelG196*0.06
UCECchr2216122132Missense_MutationnovelH188N0.28
UCECchr22162052053'UTRnovel0.06
UCECchr22162054193'UTRnovel0.12
UCECchr2216162026Missense_MutationNAQ604H0.5
UCECchr2216190251Missense_Mutationrs762387474E621K0.5
UCECchr2216130942SilentnovelS335S0.3
UCECchr2216190251Missense_Mutationrs762387474E621K0.32
UCECchr2216113091Missense_MutationnovelQ33E0.36
UCECchr22162052403'UTRrs7471211750.19
UCECchr2216190327Missense_MutationnovelA646V0.43
UCECchr2216117738Splice_Regionnovel0.3
UCSchr22161076935'Flanknovel0.18

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
HNSCDEL0.21651.278e-25
KIRPDEL0.03475.174e-05
LUSCDEL0.23751.3904e-19
MESODEL0.12640.014499
PAADAMP0.07070.1091
PAADDEL0.0380.2014
THCADEL0.0240.040844

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

KIRC0.00044

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

PAAD0.0056

Kaplan-Meier Survival Analysis

KICH0.017

Kaplan-Meier Survival Analysis

UCEC0.031

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.0016

Kaplan-Meier Survival Analysis

UVM0.00041

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000079246 (Gene tree)
Gene ID
7520
Gene Symbol
XRCC5
Alias
KU80|KARP-1|Ku86|KUB2
Full Name
X-ray repair cross complementing 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
98,840 bases
Position
chr2:216,107,464-216,206,303
Accession
12833
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22889230Virus-producing cells determine the host protein profiles of HIV-1 virion cores.Retrovirology2012 Aug 13Santos Sdoi: 10.1186/1742-4690-9-65.
15500475Tandem inverted repeat system for selection of effective transgenic RNAi strains in Chlamydomonas.Plant J2004 NovRohr J-
21846828Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.MBio2011 Aug 16Bortz Edoi: 10.1128/mBio.00151-11
16076874Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection.Blood2005 Nov 15Munakata Y-
25712094Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.Nucleic Acids Res2015 Mar 11Liang XHdoi: 10.1093/nar/gkv143
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000392133XRCC5-2023761-ENSP00000375978732 (aa)-P13010
ENST00000392132XRCC5-2013428-ENSP00000375977732 (aa)-P13010
ENST00000476360XRCC5-208610--- (aa)--
ENST00000471649XRCC5-207610--- (aa)--
ENST00000429133XRCC5-204576--- (aa)--
ENST00000460284XRCC5-2062962--- (aa)--
ENST00000417391XRCC5-203605-ENSP00000401318131 (aa)-C9JZ81
ENST00000485763XRCC5-209616--- (aa)--
ENST00000451695XRCC5-205415-ENSP0000039510819 (aa)-H7C0H9
ENST00000493706XRCC5-210564--- (aa)--
Gene Model
Click here to download ENSG00000079246's gene model file
Pathways
Pathway IDPathway NameSource
hsa03450Non-homologous end-joiningKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000079246Coronary Disease6.4010000E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000079246's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000723telomere maintenance21873635.IBAProcess
GO:0000783nuclear telomere cap complex15100233.TASComponent
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000784nuclear chromosome, telomeric region21873635.IBAComponent
GO:0000784nuclear chromosome, telomeric region10535943.IDAComponent
GO:0002218activation of innate immune response28712728.IDAProcess
GO:0003677DNA binding1537839.NASFunction
GO:0003684damaged DNA binding-IEAFunction
GO:0003690double-stranded DNA binding21873635.IBAFunction
GO:0003691double-stranded telomeric DNA binding10409678.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding14704337.IDAFunction
GO:0004003ATP-dependent DNA helicase activity-IEAFunction
GO:0005515protein binding8621488.12145306.12377759.14704337.15075319.17159921.17283121.17308091.17396150.19142223.19303849.20023628.20085707.20098424.20711232.21070772.21679440.22451927.22504299.23178593.23685356.24485452.24610814.25277244.25574025.25749521.25852083.26359349.26496610.26502055.27248496.28330616.28959974.30021884.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IEAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0006302double-strand break repair19581589.IMPProcess
GO:0006303double-strand break repair via nonhomologous end joining21873635.IBAProcess
GO:0006303double-strand break repair via nonhomologous end joining26359349.IDAProcess
GO:0006303double-strand break repair via nonhomologous end joining20383123.IMPProcess
GO:0006303double-strand break repair via nonhomologous end joining15824061.TASProcess
GO:0006310DNA recombination-IEAProcess
GO:0006974cellular response to DNA damage stimulus27248496.IMPProcess
GO:0007420brain development-IEAProcess
GO:0008022protein C-terminus binding10783163.IPIFunction
GO:0008047enzyme activator activity19188702.TASFunction
GO:0008283cell proliferation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0031625ubiquitin protein ligase binding22266820.IPIFunction
GO:0032204regulation of telomere maintenance15824061.18710952.24095731.TASProcess
GO:0032212positive regulation of telomere maintenance via telomerase19188702.IMPProcess
GO:0032481positive regulation of type I interferon production-TASProcess
GO:0032508DNA duplex unwinding-IEAProcess
GO:0032991protein-containing complex22504299.IDAComponent
GO:0032993protein-DNA complex22504299.IDAComponent
GO:0034774secretory granule lumen-TASComponent
GO:0042162telomeric DNA binding21873635.IBAFunction
GO:0042162telomeric DNA binding10535943.IDAFunction
GO:0042162telomeric DNA binding12377759.TASFunction
GO:0042493response to drug-IEAProcess
GO:0043085positive regulation of catalytic activity19188702.TASProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043564Ku70:Ku80 complex21873635.IBAComponent
GO:0043564Ku70:Ku80 complex20383123.24095731.26359349.IDAComponent
GO:0043564Ku70:Ku80 complex19188702.TASComponent
GO:0044212transcription regulatory region DNA binding18809223.IDAFunction
GO:0044877protein-containing complex binding12377759.IPIFunction
GO:0045027DNA end binding19549901.IDAFunction
GO:0045087innate immune response-IEAProcess
GO:0045860positive regulation of protein kinase activity22504299.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated8621488.IMPProcess
GO:0048660regulation of smooth muscle cell proliferation25852083.IMPProcess
GO:0050769positive regulation of neurogenesis-IEAProcess
GO:00515755'-deoxyribose-5-phosphate lyase activity20383123.IMPFunction
GO:0051973positive regulation of telomerase activity19188702.TASProcess
GO:0060218hematopoietic stem cell differentiation-IEAProcess
GO:0070198protein localization to chromosome, telomeric region19188702.TASProcess
GO:0070419nonhomologous end joining complex20383123.25941166.IDAComponent
GO:0071398cellular response to fatty acid-IEAProcess
GO:0071475cellular hyperosmotic salinity response-IEAProcess
GO:0071480cellular response to gamma radiation21873635.IBAProcess
GO:0071480cellular response to gamma radiation26359349.IDAProcess
GO:0071481cellular response to X-ray21873635.IBAProcess
GO:0075713establishment of integrated proviral latency-TASProcess
GO:0090734site of DNA damage27248496.IMPComponent
GO:1904430negative regulation of t-circle formation19581589.IMPProcess
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
GO:1990904ribonucleoprotein complex14704337.IDAComponent
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