EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19177010	Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.	Cell Cycle	2009 Feb 1	Pucci S	-
25818292	Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.	Cell Rep	2015 Mar 31	Cook R	doi: 10.1016/j.celrep.2015.02.059
24271118	Expression of Ku86 and presence of Ku86 antibody as biomarkers of hepatitis B virus related hepatocellular carcinoma.	Dig Dis Sci	2014 Mar	Xu Y	doi: 10.1007/s10620-013-2941-1
12403924	Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration.	Intervirology	2002	Liu X	-
22226916	Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway.	Carcinogenesis	2012 Mar	Wei S	doi: 10.1093/carcin/bgr319
24615008	Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer.	Med Oncol	2014 Apr	Rajaei M	doi: 10.1007/s12032-014-0885-8
17904587	A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer.	Mutat Res	2008 Feb 1	Wang S	-
21877955	Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.	Genet Test Mol Biomarkers	2012 Feb	Al-Hadyan KS	doi: 10.1089/gtmb.2011.0126
23098447	Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.	Asian Pac J Cancer Prev	2012	Zhou LP	-
17982634	Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.	Oncol Rep	2007 Dec	Someya M	-
19906305	Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.	Breast Cancer Res	2009	Nolens G	doi: 10.1186/bcr2450
20811692	The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk.	Oncol Rep	2010 Oct	Gomes BC	-
19414375	Significant association of Ku80 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan.	Anticancer Res	2009 Apr	Chang CH	-
23788213	Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.	Epidemiology	2013 Sep	Long XD	doi: 10.1097/EDE.0b013e31829d2744.
19205005	Glucose deprivation increases nuclear DNA repair protein Ku and resistance to radiation induced oxidative stress in human cancer cells.	Cell Biochem Funct	2009 Mar	Li J	doi: 10.1002/cbf.1541.
21547134	Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer.	World J Gastroenterol	2011 Apr 28	Li JQ	doi: 10.3748/wjg.v17.i16.2131.
25527410	Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5.	Pathol Oncol Res	2015 Jul	Saadat M	doi: 10.1007/s12253-014-9875-6
19528488	Significant association of Ku80 single nucleotide polymorphisms with colorectal cancer susceptibility in Central Taiwan.	Anticancer Res	2009 Jun	Yang MD	-
21137076	Ku86 is important for TrkA overexpression-induced breast cancer cell invasion.	Proteomics Clin Appl	2010 Jul	Lagadec C	doi: 10.1002/prca.200900148
20044645	Significant association of DNA repair gene Ku80 genotypes with breast cancer susceptibility in Taiwan.	Anticancer Res	2009 Dec	Wang HC	-
17671430	Bin1 interacts with and restrains the DNA end-binding protein complex Ku.	Cell Cycle	2007 Aug 1	Ramalingam A	-
26358256	Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.	Tumour Biol	2016 Feb	Chen J	doi: 10.1007/s13277-015-4048-0
26867665	Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy.	Med Mol Morphol	2016 Dec	Takada Y	-
29049411	XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.	PLoS One	2017 Oct 19	Zhang Z	doi: 10.1371/journal.pone.0186900

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.13
BLCA	chr2	216119100	Silent	rs376163776	F142F	0.61
BLCA	chr2	216127587	Frame_Shift_Ins	novel	*L284Qfs11**	0.07
BLCA	chr2	216127566	Missense_Mutation	NA	T277A	0.19
BRCA	chr2	216116832	Silent	rs768296550	Q103Q	0.07
BRCA	chr2	216122120	Missense_Mutation	rs764110781	R184C	0.12
BRCA	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.33
CESC	chr2	216109363	5'UTR	novel		0.32
CESC	chr2	216205383	3'UTR	novel		0.23
CESC	chr2	216122244	Missense_Mutation	novel	Y225F	0.71
CESC	chr2	216138151	Silent	NA	L438L	0.5
COAD	chr2	216141186	Missense_Mutation	NA	E448V	0.39
COAD	chr2	216113125	Missense_Mutation	novel	R44Q	0.28
COAD	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.29
COAD	chr2	216125994	Missense_Mutation	NA	G254D	0.4
COAD	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.21
COAD	chr2	216119096	Missense_Mutation	novel	R141Q	0.13
COAD	chr2	216148111	Missense_Mutation	rs548351594	R502Q	0.43
COAD	chr2	216132358	Silent	NA	L362L	0.09
COAD	chr2	216148110	Missense_Mutation	NA	R502W	0.42
COAD	chr2	216122202	Missense_Mutation	novel	V211A	0.35
COAD	chr2	216130930	Missense_Mutation	NA	M331I	0.24
COAD	chr2	216148249	Missense_Mutation	rs376814697	V548A	0.08
COAD	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.56
COAD	chr2	216204391	Missense_Mutation	rs772117253	D727N	0.3
COAD	chr2	216204389	Missense_Mutation	NA	D726G	0.31
COAD	chr2	216130984	Silent	novel	S349S	0.32
COAD	chr2	216141305	Frame_Shift_Del	novel	*Q488Rfs29**	0.06
COAD	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.29
COAD	chr2	216116697	Silent	novel	L58L	0.32
DLBC	chr2	216119139	Missense_Mutation	novel	K155N	0.44
DLBC	chr2	216141197	Missense_Mutation	novel	N452D	0.77
ESCA	chr2	216109316	5'UTR	novel		0.35
GBM	chr2	216148122	Missense_Mutation	novel	P506A	0.08
GBM	chr2	216161986	Missense_Mutation	novel	S591T	0.13
GBM	chr2	216205251	3'UTR	novel		0.15
GBM	chr2	216116712	Silent	novel	G63G	0.52
GBM	chr2	216205333	3'UTR	novel		0.21
GBM	chr2	216130941	Missense_Mutation	NA	S335L	0.24
GBM	chr2	216137195	Silent	novel	V407V	0.05
HNSC	chr2	216122207	Missense_Mutation	novel	I213V	0.22
HNSC	chr2	216117725	Intron	novel		0.31
HNSC	chr2	216205271	3'UTR	novel		0.1
HNSC	chr2	216137214	Missense_Mutation	novel	H414Y	0.16
HNSC	chr2	216127579	Frame_Shift_Ins	novel	*T283Nfs17**	0.29
HNSC	chr2	216138121	Missense_Mutation	novel	E428D	0.41
KIRC	chr2	216141188	Missense_Mutation	rs772908780	A449T	0.2
KIRC	chr2	216122143	Frame_Shift_Del	novel	*F192Sfs8**	0.15
KIRC	chr2	216137115	Missense_Mutation	NA	I381L	0.17
KIRP	chr2	216116840	Frame_Shift_Ins	novel	*F107Lfs15**	0.36
KIRP	chr2	216117748	Missense_Mutation	novel	L108M	0.28
LGG	chr2	216113038	Missense_Mutation	novel	D15G	0.43
LGG	chr2	216205197	Missense_Mutation	novel	I732V	0.42
LIHC	chr2	216113022	Missense_Mutation	novel	V10I	0.22
LIHC	chr2	216141281	Missense_Mutation	novel	T480A	0.32
LUAD	chr2	216130884	Missense_Mutation	NA	Y316C	0.39
LUAD	chr2	216125941	Silent	NA	V236V	0.06
LUAD	chr2	216117693	Intron	novel		0.15
LUAD	chr2	216192718	Nonsense_Mutation	novel	W675*	0.56
LUAD	chr2	216116710	Missense_Mutation	NA	G63C	0.28
LUAD	chr2	216125973	Missense_Mutation	novel	W247L	0.19
LUAD	chr2	216204344	Missense_Mutation	NA	P711R	0.19
LUAD	chr2	216192655	Missense_Mutation	novel	R654L	0.29
LUAD	chr2	216132345	Missense_Mutation	NA	M357I	0.16
LUAD	chr2	216119065	Missense_Mutation	NA	H131Y	0.08
LUAD	chr2	216148131	Nonsense_Mutation	NA	Q509*	0.36
LUSC	chr2	216127674	Missense_Mutation	novel	G313R	0.2
LUSC	chr2	216161990	Silent	novel	V592V	0.4
LUSC	chr2	216141267	Missense_Mutation	novel	D475G	0.29
LUSC	chr2	216116775	Missense_Mutation	NA	M84I	0.34
LUSC	chr2	216119066	Missense_Mutation	NA	H131P	0.3
LUSC	chr2	216109351	5'UTR	novel		1
LUSC	chr2	216109357	5'UTR	novel		0.29
LUSC	chr2	216194920	In_Frame_Del	novel	D681_L685delinsE	0.24
OV	chr2	216190280	Silent	rs368212132	P630P	0.04
OV	chr2	216109401	5'UTR	novel		0.04
OV	chr2	216138122	Nonsense_Mutation	novel	*D429delinsVSLFLGRY**	0.05
PAAD	chr2	216113101	Missense_Mutation	novel	K36R	0.17
PAAD	chr2	216138119	Missense_Mutation	novel	E428K	0.15
PCPG	chr2	216122187	Missense_Mutation	novel	E206V	0.08
PRAD	chr2	216117692	Intron	novel		0.57
READ	chr2	216125939	Missense_Mutation	rs760212422	V236I	0.14
READ	chr2	216204391	Missense_Mutation	rs772117253	D727N	0.32
READ	chr2	216161986	Missense_Mutation	novel	S591N	0.39
READ	chr2	216138122	Missense_Mutation	novel	D429N	0.23
READ	chr2	216127566	Missense_Mutation	NA	T277P	0.24
SKCM	chr2	216190313	Silent	novel	A641A	0.17
SKCM	chr2	216137112	Silent	NA	L380L	0.34
SKCM	chr2	216148154	Silent	novel	L516L	0.24
SKCM	chr2	216138174	Missense_Mutation	NA	P446L	0.23
SKCM	chr2	216205344	3'UTR	novel		0.57
SKCM	chr2	216148109	Silent	NA	P501P	0.2
SKCM	chr2	216141290	Missense_Mutation	NA	P483S	0.26
STAD	chr2	216127625	Missense_Mutation	novel	C296W	0.13
STAD	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.2
STAD	chr2	216205206	3'UTR	rs779780489		0.31
STAD	chr2	216116897	Intron	novel		0.34
STAD	chr2	216109433	5'UTR	novel		0.15
STAD	chr2	216116832	Silent	rs768296550	Q103Q	0.24
STAD	chr2	216148164	Missense_Mutation	rs761811665	A520T	0.14
STAD	chr2	216132352	Nonsense_Mutation	NA	Q360*	0.28
STAD	chr2	216137161	Missense_Mutation	NA	A396V	0.1
STAD	chr2	216127628	Frame_Shift_Del	novel	*N298Mfs9**	0.32
STAD	chr2	216204352	Missense_Mutation	NA	D714N	0.3
STAD	chr2	216122165	Missense_Mutation	NA	E199K	0.23
STAD	chr2	216127588	Missense_Mutation	NA	L284Q	0.09
STAD	chr2	216160090	Frame_Shift_Del	novel	*K566Nfs2**	0.13
STAD	chr2	216205333	3'UTR	novel		0.26
THCA	chr2	216127644	In_Frame_Ins	novel	T303delinsNLIHS	0.12
THCA	chr2	216113019	Missense_Mutation	NA	A9T	0.39
THCA	chr2	216127587	Frame_Shift_Ins	novel	*L284Qfs23**	0.12
UCEC	chr2	216204358	Missense_Mutation	NA	A716S	0.05
UCEC	chr2	216205256	3'UTR	novel		0.29
UCEC	chr2	216117750	Silent	novel	L108L	0.57
UCEC	chr2	216122165	Missense_Mutation	NA	E199K	0.31
UCEC	chr2	216204391	Missense_Mutation	rs772117253	D727N	0.31
UCEC	chr2	216205307	3'UTR	novel		0.39
UCEC	chr2	216204362	Missense_Mutation	novel	A717D	0.29
UCEC	chr2	216125939	Missense_Mutation	rs760212422	V236I	0.37
UCEC	chr2	216122127	Missense_Mutation	novel	G186D	0.45
UCEC	chr2	216127611	Nonsense_Mutation	novel	E292*	0.3
UCEC	chr2	216205370	3'UTR	novel		0.09
UCEC	chr2	216160096	Missense_Mutation	novel	L567I	0.48
UCEC	chr2	216125939	Missense_Mutation	rs760212422	V236I	0.14
UCEC	chr2	216116823	Silent	rs755967499	P100P	0.2
UCEC	chr2	216141185	Splice_Site	novel	X448_splice	0.18
UCEC	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.28
UCEC	chr2	216190336	Splice_Site	NA	X648_splice	0.45
UCEC	chr2	216148084	Missense_Mutation	novel	C493Y	0.41
UCEC	chr2	216141294	Missense_Mutation	novel	N484T	0.47
UCEC	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.41
UCEC	chr2	216127589	Frame_Shift_Del	NA	*E287Kfs11**	0.41
UCEC	chr2	216122067	Missense_Mutation	novel	P166H	0.55
UCEC	chr2	216205235	3'UTR	novel		0.45
UCEC	chr2	216205240	3'UTR	rs747121175		0.99
UCEC	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.31
UCEC	chr2	216113039	Silent	rs769816648	D15D	0.48
UCEC	chr2	216116952	Intron	novel		0.25
UCEC	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.4
UCEC	chr2	216117773	Missense_Mutation	novel	D116G	0.33
UCEC	chr2	216107675	5'Flank	novel		0.23
UCEC	chr2	216137154	Nonsense_Mutation	novel	R394*	0.35
UCEC	chr2	216122159	Missense_Mutation	novel	I197L	0.13
UCEC	chr2	216113125	Missense_Mutation	novel	R44Q	0.48
UCEC	chr2	216126027	Missense_Mutation	novel	K265T	0.28
UCEC	chr2	216192690	Missense_Mutation	novel	V666L	0.3
UCEC	chr2	216204338	Missense_Mutation	novel	D709G	0.25
UCEC	chr2	216205205	3'UTR	novel		0.45
UCEC	chr2	216116765	Missense_Mutation	novel	R81I	0.24
UCEC	chr2	216122156	Nonsense_Mutation	novel	G196*	0.06
UCEC	chr2	216122132	Missense_Mutation	novel	H188N	0.28
UCEC	chr2	216205205	3'UTR	novel		0.06
UCEC	chr2	216205419	3'UTR	novel		0.12
UCEC	chr2	216162026	Missense_Mutation	NA	Q604H	0.5
UCEC	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.5
UCEC	chr2	216130942	Silent	novel	S335S	0.3
UCEC	chr2	216190251	Missense_Mutation	rs762387474	E621K	0.32
UCEC	chr2	216113091	Missense_Mutation	novel	Q33E	0.36
UCEC	chr2	216205240	3'UTR	rs747121175		0.19
UCEC	chr2	216190327	Missense_Mutation	novel	A646V	0.43
UCEC	chr2	216117738	Splice_Region	novel		0.3
UCS	chr2	216107693	5'Flank	novel		0.18

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.2165	1.278e-25
KIRP	DEL	0.0347	5.174e-05
LUSC	DEL	0.2375	1.3904e-19
MESO	DEL	0.1264	0.014499
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.038	0.2014
THCA	DEL	0.024	0.040844

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
KIRC	0.00044	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0056	Kaplan-Meier Survival Analysis
KICH	0.017	Kaplan-Meier Survival Analysis
UCEC	0.031	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0016	Kaplan-Meier Survival Analysis
UVM	0.00041	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000079246 (Gene tree)
Gene ID: 7520
Gene Symbol: XRCC5
Alias: KU80|KARP-1|Ku86|KUB2
Full Name: X-ray repair cross complementing 5
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 98,840 bases
Position: chr2:216,107,464-216,206,303
Accession: 12833
Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22889230	Virus-producing cells determine the host protein profiles of HIV-1 virion cores.	Retrovirology	2012 Aug 13	Santos S	doi: 10.1186/1742-4690-9-65.
15500475	Tandem inverted repeat system for selection of effective transgenic RNAi strains in Chlamydomonas.	Plant J	2004 Nov	Rohr J	-
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
16076874	Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection.	Blood	2005 Nov 15	Munakata Y	-
25712094	Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.	Nucleic Acids Res	2015 Mar 11	Liang XH	doi: 10.1093/nar/gkv143

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000392133	XRCC5-202	3761	-	ENSP00000375978	732 (aa)	-	P13010
ENST00000392132	XRCC5-201	3428	-	ENSP00000375977	732 (aa)	-	P13010
ENST00000476360	XRCC5-208	610	-	-	- (aa)	-	-
ENST00000471649	XRCC5-207	610	-	-	- (aa)	-	-
ENST00000429133	XRCC5-204	576	-	-	- (aa)	-	-
ENST00000460284	XRCC5-206	2962	-	-	- (aa)	-	-
ENST00000417391	XRCC5-203	605	-	ENSP00000401318	131 (aa)	-	C9JZ81
ENST00000485763	XRCC5-209	616	-	-	- (aa)	-	-
ENST00000451695	XRCC5-205	415	-	ENSP00000395108	19 (aa)	-	H7C0H9
ENST00000493706	XRCC5-210	564	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03450	Non-homologous end-joining	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000079246	Coronary Disease	6.4010000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000079246's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	21873635.	IBA	Process
GO:0000783	nuclear telomere cap complex	15100233.	TAS	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0000784	nuclear chromosome, telomeric region	10535943.	IDA	Component
GO:0002218	activation of innate immune response	28712728.	IDA	Process
GO:0003677	DNA binding	1537839.	NAS	Function
GO:0003684	damaged DNA binding	-	IEA	Function
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003691	double-stranded telomeric DNA binding	10409678.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	14704337.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	-	IEA	Function
GO:0005515	protein binding	8621488.12145306.12377759.14704337.15075319.17159921.17283121.17308091.17396150.19142223.19303849.20023628.20085707.20098424.20711232.21070772.21679440.22451927.22504299.23178593.23685356.24485452.24610814.25277244.25574025.25749521.25852083.26359349.26496610.26502055.27248496.28330616.28959974.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006302	double-strand break repair	19581589.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	26359349.	IDA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	20383123.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	15824061.	TAS	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	27248496.	IMP	Process
GO:0007420	brain development	-	IEA	Process
GO:0008022	protein C-terminus binding	10783163.	IPI	Function
GO:0008047	enzyme activator activity	19188702.	TAS	Function
GO:0008283	cell proliferation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031625	ubiquitin protein ligase binding	22266820.	IPI	Function
GO:0032204	regulation of telomere maintenance	15824061.18710952.24095731.	TAS	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	19188702.	IMP	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0032991	protein-containing complex	22504299.	IDA	Component
GO:0032993	protein-DNA complex	22504299.	IDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0042162	telomeric DNA binding	21873635.	IBA	Function
GO:0042162	telomeric DNA binding	10535943.	IDA	Function
GO:0042162	telomeric DNA binding	12377759.	TAS	Function
GO:0042493	response to drug	-	IEA	Process
GO:0043085	positive regulation of catalytic activity	19188702.	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043564	Ku70:Ku80 complex	21873635.	IBA	Component
GO:0043564	Ku70:Ku80 complex	20383123.24095731.26359349.	IDA	Component
GO:0043564	Ku70:Ku80 complex	19188702.	TAS	Component
GO:0044212	transcription regulatory region DNA binding	18809223.	IDA	Function
GO:0044877	protein-containing complex binding	12377759.	IPI	Function
GO:0045027	DNA end binding	19549901.	IDA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045860	positive regulation of protein kinase activity	22504299.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	8621488.	IMP	Process
GO:0048660	regulation of smooth muscle cell proliferation	25852083.	IMP	Process
GO:0050769	positive regulation of neurogenesis	-	IEA	Process
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	20383123.	IMP	Function
GO:0051973	positive regulation of telomerase activity	19188702.	TAS	Process
GO:0060218	hematopoietic stem cell differentiation	-	IEA	Process
GO:0070198	protein localization to chromosome, telomeric region	19188702.	TAS	Process
GO:0070419	nonhomologous end joining complex	20383123.25941166.	IDA	Component
GO:0071398	cellular response to fatty acid	-	IEA	Process
GO:0071475	cellular hyperosmotic salinity response	-	IEA	Process
GO:0071480	cellular response to gamma radiation	21873635.	IBA	Process
GO:0071480	cellular response to gamma radiation	26359349.	IDA	Process
GO:0071481	cellular response to X-ray	21873635.	IBA	Process
GO:0075713	establishment of integrated proviral latency	-	TAS	Process
GO:0090734	site of DNA damage	27248496.	IMP	Component
GO:1904430	negative regulation of t-circle formation	19581589.	IMP	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process
GO:1990904	ribonucleoprotein complex	14704337.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.