EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25198665miR-133a functions as a tumor suppressor and directly targets FSCN1 in pancreatic cancer.Oncol Res2013Qin Ydoi: 10.3727/096504014X14024160459122.
21491467Fascin, an actin-bundling protein, promotes breast cancer progression in vitro.Cell Biochem Funct2011 JunXing Pdoi: 10.1002/cbf.1750.
30060981Fascin1 promotes gastric cancer progression by facilitatingcell migrationand epithelial-mesenchymal transition.Pathol Res Pract2018 SepWang Gdoi: 10.1016/j.prp.2018.06.018
25155376Fascin and EMMPRIN expression in primary mucinous tumors of ovary: a tissue microarray study.Pathol Res Pract2014 DecAlici Odoi: 10.1016/j.prp.2014.07.003
18587253Does the expression of fascin-1 and tumor subclassification help to assess the risk of recurrence and progression in t1 urothelial urinary bladder carcinoma?Urol Int2008Soukup Vdoi: 10.1159/000132700
17473384Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters.Dis Markers2007Tsai WC-
26349603Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer.J Environ Pathol Toxicol Oncol2015Omran OM-
22128198Fascin expression in endocervical neoplasia: correlation with tumour morphology and growth pattern.J Clin Pathol2012 MarStewart CJdoi: 10.1136/jclinpath-2011-200425
19115695Fascin can be an auxiliary immunomarker of ovarian granulosa cell tumors: comparison with calretinin and inhibin-alpha.Eur J Gynaecol Oncol2008Kostopoulou E-
26503504MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1.J Exp Clin Cancer Res2015 Oct 26Li YQdoi: 10.1186/s13046-015-0242-6.
20596974Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.Head Neck Pathol2009 SepWu HHdoi: 10.1007/s12105-009-0133-2
21914811Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells.J Biol Chem2011 Nov 11Sun Jdoi: 10.1074/jbc.M111.270413
23030700The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.APMIS2013 MarTsai WCdoi: 10.1111/j.1600-0463.2012.02952.x
21498718Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.Anticancer Res2011 MarTakikita M-
23196799Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor.Mod Pathol2013 AprYamamoto Hdoi: 10.1038/modpathol.2012.198
19556073Prognostic significance of fascin expression in extrahepatic bile duct carcinomas.Pathol Res Pract2009Won KYdoi: 10.1016/j.prp.2009.05.009
21390241The prognostic impact of TGF-β1, fascin, NF-??B and PKC-?? expression in soft tissue sarcomas.PLoS One2011 Mar 3Valkov Adoi: 10.1371/journal.pone.0017507.
18851787[Correlation of Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) to fascin and phosphorylated Stat3 in nasopharyngeal carcinoma].Ai Zheng2008 OctLiu QY-
27566402MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.Proc Natl Acad Sci U S A2016 Sep 13Anderson Sdoi: 10.1073/pnas.1610994113
30542700Fascin is involved in cancer cell invasion and is regulated by stromal factors.Oncol Rep2019 JanZhang Xdoi: 10.3892/or.2018.6847
23899558MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer.Cell Signal2014 JanChen MBdoi: 10.1016/j.cellsig.2013.07.017
22110277Fascin promotes the motility and invasiveness of pancreatic cancer cells.World J Gastroenterol2011 Oct 28Xu YFdoi: 10.3748/wjg.v17.i40.4470.
25815687MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1.Mol Med Rep2015 JulLai Cdoi: 10.3892/mmr.2015.3545
21937440Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration.J Biol Chem2011 Nov 11Snyder Mdoi: 10.1074/jbc.M111.286245
23393326Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer.Anticancer Res2013 FebHanker LC-
17510372Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters.J Histochem Cytochem2007 SepTsai WC-
22076152Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules.PLoS One2011Al-Alwan Mdoi: 10.1371/journal.pone.0027339
24642628MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1.Br J Cancer2014 Apr 29Feng Ydoi: 10.1038/bjc.2014.122
26886283Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling.Tumour Biol2016 AugLiang Zdoi: 10.1007/s13277-016-4934-0
26010149Reverse Correlation between MicroRNA-145 and FSCN1 Affecting Gastric Cancer Migration and Invasion.PLoS One2015 May 26Chen JJdoi: 10.1371/journal.pone.0126890
20001345Knockdown of fascin1 expression suppresses the proliferation and metastasis of gastric cancer cells.Pathology2009Fu Hdoi: 10.3109/00313020903273100.
23252866Fascin expression is related to poor survival in gastric cancer.Pathol Int2012 DecKim SJdoi: 10.1111/pin.12012.
17638895Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.Cancer Res2007 Jul 15Vignjevic D-
19818782Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression.Gastroenterology2010 MarKim SJdoi: 10.1053/j.gastro.2009.09.061
28230028Leucine-rich repeats and immunoglobulin-like domains protein 1 and fascin actin-bundling protein 1 expression in nonsmall cell lung cancer.J Cancer Res Ther2016 DecZhang Jdoi: 10.4103/0973-1482.200749.
19819618Upregulated fascin1 in non-small cell lung cancer promotes the migration and invasiveness, but not proliferation.Cancer Lett2010 Apr 28Zhao Jdoi: 10.1016/j.canlet.2009.09.013
15671545The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course.Clin Cancer Res2005 Jan 1Yoder BJ-
26211585The clinical significance of FSCN1 in non-small cell lung cancer.Biomed Pharmacother2015 JulLuo Adoi: 10.1016/j.biopha.2015.05.014
26173501MicroRNA-145 and MicroRNA-133a Inhibited Proliferation, Migration, and Invasion, While Promoted Apoptosis in Hepatocellular Carcinoma Cells Via Targeting FSCN1.Dig Dis Sci2015 OctWang Gdoi: 10.1007/s10620-015-3706-9
25433493The role of microRNA-133b and its target gene FSCN1 in gastric cancer.J Exp Clin Cancer Res2014 Nov 30Guo Ldoi: 10.1186/s13046-014-0099-0.
19657566TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways.Acta Biochim Biophys Sin (Shanghai)2009 AugFu H-
23986556Strong association of fascin expression with triple negative breast cancer and basal-like phenotype in African-American women.J Clin Pathol2014 FebEsnakula AKdoi: 10.1136/jclinpath-2013-201698
20819441Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.J Int Med Res2010 May-JunZhang Y-
21258769Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1.Int J Oncol2011 AprFuse Mdoi: 10.3892/ijo.2011.919
24235142GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion.J Biol Chem2013 Dec 27Sun Jdoi: 10.1074/jbc.M113.506535
28653739Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer.Genet Mol Res2017 Jun 20Yang Ldoi: 10.4238/gmr16029617.
27502039Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway.Stem Cells2016 DecBarnawi Rdoi: 10.1002/stem.2473
28251354Fascin phosphorylation sites combine to regulate esophageal squamous cancer cell behavior.Amino Acids2017 MayZeng FMdoi: 10.1007/s00726-017-2398-1
29458026Knockdown of fascin-1 expression suppresses cell migration and invasion of non-small cell lung cancer by regulating the MAPK pathway.Biochem Biophys Res Commun2018 Mar 4Zhao Ddoi: 10.1016/j.bbrc.2018.02.134
28922730Long non-coding RNA PCAT-1 contributes to tumorigenesis by regulating FSCN1 via miR-145-5p in prostate cancer.Biomed Pharmacother2017 NovXu Wdoi: 10.1016/j.biopha.2017.09.019
29052029Migration and invasion induced by linoleic acid are mediated through fascin in MDA-MB-231 breast cancer cells.Mol Cell Biochem2018 JunGonzalez-Reyes Cdoi: 10.1007/s11010-017-3205-8
30231243FSCN1 Promotes Epithelial-Mesenchymal Transition Through Increasing Snail1 in Ovarian Cancer Cells.Cell Physiol Biochem2018Li Jdoi: 10.1159/000493622
29970665Expression of fascin_1 protein in cancer tissues of patients with nonsmall cell lung cancer and its relevance to patients' clinicopathologic features and prognosis.J Cancer Res Ther2018Zhang Ydoi: 10.4103/jcrt.JCRT_732_17.
30056535Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model.Inflamm Res2018 OctKanda Ydoi: 10.1007/s00011-018-1175-2
29496994Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with I??B kinase (IKK) in colon cancer.J Biol Chem2018 Apr 27Matsumura Tdoi: 10.1074/jbc.M117.819201
29371698Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.Exp Mol Med2018 Jan 26Jeong BYdoi: 10.1038/emm.2017.248.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr75593510Missense_Mutationrs779894288D192N0.14
BLCAchr75593234Missense_MutationnovelR100C0.7
BLCAchr75593503Missense_MutationNAQ189H0.09
BLCAchr75593464SilentnovelL176L0.54
BLCAchr75603322Missense_Mutationrs535034843R300C0.42
BLCAchr75605390Silentrs568861608G466G0.13
BLCAchr75603277Missense_MutationnovelQ285E0.38
BLCAchr75593548SilentnovelA204A0.19
BRCAchr75603551Missense_MutationNAA349S0.2
BRCAchr75605360Silentrs550354749C456C0.19
CESCchr75593339Missense_MutationnovelH135Y0.4
CESCchr75603936Silentrs763345590I395I0.25
CESCchr75603357SilentnovelT311T0.4
CESCchr75593114Missense_MutationnovelV60L0.77
CESCchr75603944Missense_Mutationrs761467264R398H0.39
CESCchr75603288Missense_MutationnovelE288D0.26
CESCchr75605415Missense_MutationnovelA475T0.17
CHOLchr75593072Missense_MutationnovelW46R0.42
CHOLchr75605458Missense_MutationnovelS489L0.43
COADchr75603943Missense_Mutationrs751111507R398C0.32
COADchr75603899Missense_Mutationrs755808795R383H0.17
COADchr75605377Missense_MutationNAA462V0.3
COADchr75603529SilentNAR341R0.32
COADchr75603898Missense_MutationNAR383C0.6
COADchr75605390Silentrs568861608G466G0.41
COADchr75605325Missense_Mutationrs756163037G445S0.36
COADchr75593377SilentnovelV147V0.05
COADchr75605377Missense_MutationNAA462V0.19
COADchr75593262Missense_MutationNAR109Q0.3
GBMchr75605394Missense_MutationnovelR468C0.22
GBMchr75603503Missense_MutationnovelS333R0.08
GBMchr75605398Missense_MutationnovelY469C0.18
GBMchr75605432SilentnovelA480A0.09
HNSCchr75603223Intronnovel0.13
HNSCchr75593253Frame_Shift_InsnovelA107Gfs*440.3
HNSCchr75603177Intronnovel0.11
HNSCchr75593145Missense_MutationnovelL70Q0.25
HNSCchr75603865Missense_MutationnovelD372H0.48
HNSCchr75605312Silentrs564738398A440A0.2
KIRCchr75593354Missense_MutationNAP140S0.37
KIRCchr75593111Missense_MutationNAA59P0.35
KIRPchr75593646Missense_Mutationrs760329855S237N0.14
LGGchr75603537Missense_Mutationrs756533788R344H0.17
LGGchr75605409Missense_Mutationrs755224753D473N0.65
LIHCchr75603374Missense_MutationNAL317Q0.17
LIHCchr756054843'UTRnovel0.63
LIHCchr75605390Silentrs568861608G466G0.27
LIHCchr75593401SilentnovelL155L0.31
LIHCchr75592948Missense_MutationnovelN4K0.28
LIHCchr75603915SilentnovelF388F0.67
LUADchr75603232Intronnovel0.28
LUADchr75603552Missense_Mutationrs754279900A349V0.11
LUADchr75593256Missense_Mutationrs758856457A107E0.34
LUADchr75593760Missense_MutationnovelT275K0.22
LUADchr75603256Splice_SitenovelX278_splice0.39
LUADchr75605345Missense_MutationnovelF451L0.22
OVchr75603211Intronnovel0.16
OVchr75603933SilentNAF394F0.82
PAADchr75605352Missense_MutationnovelE454K0.21
PRADchr75604022Missense_MutationnovelN424T0.39
READchr75603890Missense_MutationnovelL380P0.15
READchr75603321SilentnovelD299D0.15
SARCchr75593190Missense_MutationnovelP85L0.24
SKCMchr75603329Missense_MutationNAT302I0.42
SKCMchr75603362Missense_MutationNAK313R0.11
SKCMchr75603152Intronnovel0.24
SKCMchr75603879SilentNAF376F0.24
SKCMchr75603879SilentNAF376F0.2
SKCMchr75593475Missense_MutationNAA180V0.33
SKCMchr75603318Silentrs147410388I298I0.32
SKCMchr75593473SilentNAL179L0.2
SKCMchr75603565Missense_MutationNAK353N0.11
SKCMchr75603879SilentNAF376F0.32
STADchr75603283Missense_MutationNAE287K0.23
STADchr75593161SilentnovelD75D0.26
STADchr75593040Missense_MutationNAA35V0.25
STADchr75593506SilentNAT190T0.13
STADchr75603918Silentrs776771373R389R0.11
STADchr75593289Missense_MutationNAR118H0.26
STADchr75593664Missense_MutationnovelG243D0.67
STADchr75593138Missense_MutationNAR68C0.42
STADchr75605312Silentrs564738398A440A0.46
STADchr75603172Intronnovel0.26
STADchr75593420Missense_MutationNAE162K0.25
STADchr75603552Missense_Mutationrs754279900A349V0.49
STADchr75603528Missense_Mutationrs377275041R341H0.15
THCAchr75593064Missense_MutationnovelK43R0.32
UCECchr75603206Intronnovel0.19
UCECchr75593070Missense_MutationnovelI45N0.35
UCECchr75603241Intronnovel0.33
UCECchr75603403Missense_MutationNAA327T0.24
UCECchr75603873Missense_MutationNAE374D0.14
UCECchr75603325Missense_MutationNAD301N0.22
UCECchr75603086Intronnovel0.27
UCECchr75603288Missense_MutationnovelE288D0.46
UCECchr75593012Missense_MutationnovelA26T0.17
UCECchr75605445Missense_Mutationrs775066481V485M0.15
UCECchr75593136Missense_MutationnovelG67D0.51
UCECchr75603596Missense_MutationnovelA364T0.3
UCECchr756055123'UTRrs7488919860.21
UCECchr75605394Missense_MutationnovelR468C0.33
UCECchr75603537Missense_Mutationrs756533788R344H0.29
UCECchr75603371Missense_Mutationrs143738037T316M0.18
UCECchr75603923Missense_MutationnovelE391G0.36
UCSchr75605444SilentnovelT484T0.67

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.58890.24436
LUADAMP0.45540.17291
OVDEL0.40593.8574e-27
SKCMAMP0.50680.00015162
STADAMP0.44670.0078915
TGCTAMP0.720.019484
THCADEL00.27619

Survival Analysis
CancerP-value Q-value
KIRC0.0054

Kaplan-Meier Survival Analysis

SARC0.015

Kaplan-Meier Survival Analysis

MESO0.00021

Kaplan-Meier Survival Analysis

ACC0.00015

Kaplan-Meier Survival Analysis

HNSC0.00066

Kaplan-Meier Survival Analysis

COAD0.016

Kaplan-Meier Survival Analysis

PAAD0.0072

Kaplan-Meier Survival Analysis

PCPG0.031

Kaplan-Meier Survival Analysis

BLCA0.0093

Kaplan-Meier Survival Analysis

CESC0.019

Kaplan-Meier Survival Analysis

READ0.048

Kaplan-Meier Survival Analysis

UCEC0.019

Kaplan-Meier Survival Analysis

LIHC0.0074

Kaplan-Meier Survival Analysis

LGG0.011

Kaplan-Meier Survival Analysis

LUAD0.00029

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000075618 (Gene tree)
Gene ID
6624
Gene Symbol
FSCN1
Alias
p55|FLJ38511|SNL
Full Name
fascin actin-bundling protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
13,852 bases
Position
chr7:5,592,805-5,606,656
Accession
11148
RBP type
non-canonical RBP
Summary
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000382361FSCN1-2012777-ENSP00000371798493 (aa)-Q16658
ENST00000447103FSCN1-204713-ENSP00000409967120 (aa)-C9JPH9
ENST00000473330FSCN1-2052215--- (aa)--
ENST00000444748FSCN1-203580-ENSP00000404506132 (aa)-C9JFC0
ENST00000405801FSCN1-202550-ENSP00000383982137 (aa)-A0A0A0MSB2
Gene Model
Click here to download ENSG00000075618's gene model file
Pathways
Pathway IDPathway NameSource
hsa05206MicroRNAs in cancerKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075618's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001725stress fiber3525578.IDAComponent
GO:0001726ruffle21873635.IBAComponent
GO:0001726ruffle3525578.IDAComponent
GO:0002102podosome20137952.IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0003779actin binding8999969.20393565.IDAFunction
GO:0005515protein binding15161933.20603015.21706053.IPIFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm9571235.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton9571235.IDAComponent
GO:0005902microvillus21873635.IBAComponent
GO:0005902microvillus9571235.IDAComponent
GO:0005911cell-cell junction9571235.IDAComponent
GO:0007043cell-cell junction assembly9571235.IDAProcess
GO:0007163establishment or maintenance of cell polarity21873635.IBAProcess
GO:0008144drug binding20393565.IDAFunction
GO:0008283cell proliferation8068206.TASProcess
GO:0010592positive regulation of lamellipodium assembly9571235.IDAProcess
GO:0015629actin cytoskeleton3525578.IDAComponent
GO:0016477cell migration21873635.IBAProcess
GO:0016477cell migration20393565.IMPProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0030027lamellipodium21873635.IBAComponent
GO:0030027lamellipodium-ISSComponent
GO:0030035microspike assembly9571235.IDAProcess
GO:0030035microspike assembly20137952.IMPProcess
GO:0030036actin cytoskeleton organization9571235.IDAProcess
GO:0030175filopodium21873635.IBAComponent
GO:0030175filopodium3525578.20137952.IDAComponent
GO:0030426growth cone21873635.IBAComponent
GO:0030426growth cone-ISSComponent
GO:0030674protein binding, bridging-IEAFunction
GO:0031253cell projection membrane21873635.IBAComponent
GO:0031253cell projection membrane9571235.IDAComponent
GO:0032534regulation of microvillus assembly9571235.IDAProcess
GO:0032956regulation of actin cytoskeleton organization20137952.IDAProcess
GO:0035089establishment of apical/basal cell polarity9571235.IDAProcess
GO:0044393microspike3525578.9571235.20137952.IDAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0048870cell motility9571235.IDAProcess
GO:0051015actin filament binding21873635.IBAFunction
GO:0051015actin filament binding8999969.17671164.IDAFunction
GO:0051017actin filament bundle assembly21873635.IBAProcess
GO:0051017actin filament bundle assembly20393565.IDAProcess
GO:0051491positive regulation of filopodium assembly9571235.IDAProcess
GO:0051491positive regulation of filopodium assembly20137952.IMPProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071437invadopodium20137952.IDAComponent
GO:0071803positive regulation of podosome assembly20137952.IDAProcess
GO:0090091positive regulation of extracellular matrix disassembly20137952.IDAProcess
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