EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	65556875	Missense_Mutation	novel	S114C	0.22
BLCA	chr15	65570204	Splice_Site	novel	X258_splice	0.29
BLCA	chr15	65554951	Silent	NA	V65V	0.28
BLCA	chr15	65572232	Splice_Region	novel		0.09
BRCA	chr15	65576647	3'UTR	novel		0.17
BRCA	chr15	65576504	3'UTR	novel		0.52
CESC	chr15	65576357	Frame_Shift_Del	novel	*K358Rfs17**	0.35
CESC	chr15	65576647	3'UTR	novel		0.33
CESC	chr15	65570120	Silent	novel	I230I	0.2
CESC	chr15	65576364	Missense_Mutation	NA	K358N	0.39
CESC	chr15	65576604	3'UTR	novel		0.37
CESC	chr15	65576489	3'UTR	NA		0.34
COAD	chr15	65530499	5'UTR	novel		0.36
COAD	chr15	65576314	Missense_Mutation	novel	N342H	0.08
COAD	chr15	65556737	Splice_Site	novel	X69_splice	0.34
COAD	chr15	65576351	Missense_Mutation	novel	Y354C	0.08
COAD	chr15	65554912	Silent	novel	D52D	0.36
COAD	chr15	65562796	Silent	NA	G148G	0.13
COAD	chr15	65562864	Missense_Mutation	NA	R171Q	0.24
COAD	chr15	65576364	Missense_Mutation	NA	K358N	0.19
COAD	chr15	65556783	Silent	NA	Q83Q	0.17
COAD	chr15	65556757	Missense_Mutation	NA	Q75K	0.24
ESCA	chr15	65576357	Frame_Shift_Del	novel	*K358Rfs17**	0.37
ESCA	chr15	65562877	Missense_Mutation	novel	L175F	0.24
ESCA	chr15	65564214	Splice_Site	novel	X178_splice	0.16
ESCA	chr15	65554940	Missense_Mutation	rs186662742	L62V	0.11
ESCA	chr15	65572349	Missense_Mutation	novel	L332P	0.35
ESCA	chr15	65577984	3'UTR	novel		0.52
GBM	chr15	65562824	Missense_Mutation	novel	F158I	0.09
GBM	chr15	65564321	Silent	rs770153021	P213P	0.23
HNSC	chr15	65572280	Missense_Mutation	rs768554778	R309Q	0.09
KIRP	chr15	65530624	5'UTR	novel		0.35
LGG	chr15	65554939	Silent	novel	F61F	0.32
LIHC	chr15	65556847	Missense_Mutation	novel	P105S	0.18
LIHC	chr15	65530516	5'UTR	novel		0.6
LUAD	chr15	65554894	Silent	novel	G46G	0.12
MESO	chr15	65572352	Frame_Shift_Ins	novel	*M334Nfs15**	0.25
OV	chr15	65562803	Missense_Mutation	rs781348893	F151L	0.18
OV	chr15	65570107	Missense_Mutation	novel	F226S	0.06
OV	chr15	65558732	Splice_Site	novel	X141_splice	0.06
PAAD	chr15	65530632	Translation_Start_Site	NA	M1?	0.4
PRAD	chr15	65576320	Missense_Mutation	rs769410818	R344C	0.28
READ	chr15	65556873	Silent	NA	E113E	0.39
SKCM	chr15	65570183	Nonsense_Mutation	NA	W251*	0.3
SKCM	chr15	65558715	Silent	rs372958001	S135S	0.6
SKCM	chr15	65564320	Missense_Mutation	rs570046325	P213L	0.62
STAD	chr15	65576357	Frame_Shift_Del	novel	*K358Rfs17**	0.19
STAD	chr15	65571613	Missense_Mutation	rs756832499	T280I	0.41
STAD	chr15	65564314	Missense_Mutation	rs778632006	T211M	0.1
UCEC	chr15	65576460	3'UTR	novel		0.5
UCEC	chr15	65570195	Missense_Mutation	NA	E255D	0.37
UCEC	chr15	65572296	Silent	rs776091890	L314L	0.37
UCEC	chr15	65576613	3'UTR	novel		0.33
UCEC	chr15	65576461	3'UTR	novel		0.58
UCEC	chr15	65577805	3'UTR	novel		0.32
UCEC	chr15	65556860	Missense_Mutation	rs757902811	R109H	0.41
UCEC	chr15	65570103	Missense_Mutation	novel	N225H	0.05
UCEC	chr15	65576387	3'UTR	novel		0.21
UCEC	chr15	65576432	3'UTR	novel		0.15
UCEC	chr15	65576461	3'UTR	novel		0.27
UCEC	chr15	65572359	Silent	novel	I335I	0.13
UCEC	chr15	65576429	3'UTR	novel		0.3
UCEC	chr15	65576348	Missense_Mutation	rs199662967	R353H	0.48
UCEC	chr15	65564320	Missense_Mutation	rs570046325	P213L	0.38
UCEC	chr15	65564214	Splice_Site	novel	X178_splice	0.34
UCEC	chr15	65576483	3'UTR	novel		0.33
UCEC	chr15	65554907	Nonsense_Mutation	novel	G51*	0.4
UCEC	chr15	65562879	Frame_Shift_Ins	novel	*E178Rfs5**	0.52
UCEC	chr15	65572329	Silent	NA	S325S	0.38
UCEC	chr15	65576367	Missense_Mutation	NA	K359N	0.49
UCEC	chr15	65571606	Missense_Mutation	rs143107393	R278C	0.36
UCEC	chr15	65556786	Missense_Mutation	novel	K84N	0.43
UCEC	chr15	65572272	Missense_Mutation	novel	E306D	0.23
UCEC	chr15	65562816	Missense_Mutation	NA	L155R	0.12
UCEC	chr15	65570117	Silent	novel	F229F	0.47
UCEC	chr15	65572276	Missense_Mutation	rs151201949	G308R	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KICH	AMP	0.2727	0.21756
LGG	AMP	0.0175	0.19963
PAAD	AMP	0.0652	0.20695
PAAD	DEL	0.1141	0.13216

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0011	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
MESO	0.021	Kaplan-Meier Survival Analysis
ACC	0.0085	Kaplan-Meier Survival Analysis
HNSC	0.009	Kaplan-Meier Survival Analysis
BRCA	0.043	Kaplan-Meier Survival Analysis
BLCA	0.013	Kaplan-Meier Survival Analysis
READ	0.038	Kaplan-Meier Survival Analysis
LGG	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000074696 (Gene tree)
Gene ID: 51495
Gene Symbol: HACD3
Alias: B-ind1|HSPC121|PTPLAD1
Full Name: 3-hydroxyacyl-CoA dehydratase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 47,938 bases
Position: chr15:65,530,418-65,578,355
Accession: 24175
RBP type: non-canonical RBP
Summary: (3-Hydroxyacyl-CoA Dehydratase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include enzyme binding and lyase activity. An important paralog of this gene is HACD4.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000562901	HACD3-205	1797	-	ENSP00000455686	245 (aa)	-	H3BRL8
ENST00000568793	HACD3-210	1824	-	ENSP00000455530	337 (aa)	-	H3BPZ1
ENST00000565299	HACD3-206	1465	-	ENSP00000456568	400 (aa)	-	H3BS72
ENST00000562832	HACD3-204	789	-	ENSP00000454610	139 (aa)	-	H3BMZ1
ENST00000566239	HACD3-208	393	-	-	- (aa)	-	-
ENST00000566511	HACD3-209	1782	-	ENSP00000455587	245 (aa)	-	H3BRL8
ENST00000261875	HACD3-201	3228	-	ENSP00000261875	362 (aa)	-	Q9P035
ENST00000569894	HACD3-211	1471	-	ENSP00000454873	245 (aa)	-	H3BRL8
ENST00000566074	HACD3-207	1658	XM_011521664	ENSP00000456300	245 (aa)	XP_011519966	H3BRL8
ENST00000442729	HACD3-202	1332	-	ENSP00000392491	307 (aa)	-	Q9P035
ENST00000624437	HACD3-212	2746	-	-	- (aa)	-	-
ENST00000561763	HACD3-203	483	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000074696's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00062	Fatty acid elongation	KEGG
hsa01040	Biosynthesis of unsaturated fatty acids	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01212	Fatty acid metabolism	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000074696	rs12916360	15	65564467	T	Intelligence (MTAG)	29326435	[0.016-0.034] unit increase	0.025131594	EFO_0004337
ENSG00000074696	rs2456015	15	65538180	T	Mean corpuscular hemoglobin concentration	27863252	[0.017-0.033] unit increase	0.02469321	EFO_0004528
ENSG00000074696	rs28457012	15	65555773	?	General cognitive ability	29844566	z-score decrease	4.556	EFO_0004337
ENSG00000074696	rs13380251	15	65538681	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074696's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005096	GTPase activator activity	10747961.	TAS	Function
GO:0005515	protein binding	18160438.23935497.	IPI	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005783	endoplasmic reticulum	18554506.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	IEA	Process
GO:0007257	activation of JUN kinase activity	10747961.	TAS	Process
GO:0007264	small GTPase mediated signal transduction	10747961.	TAS	Process
GO:0007266	Rho protein signal transduction	-	IEA	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016601	Rac protein signal transduction	10747961.	NAS	Process
GO:0018812	3-hydroxyacyl-CoA dehydratase activity	21873635.	IBA	Function
GO:0018812	3-hydroxyacyl-CoA dehydratase activity	18554506.	IDA	Function
GO:0019899	enzyme binding	18554506.	IDA	Function
GO:0030148	sphingolipid biosynthetic process	21873635.	IBA	Process
GO:0030497	fatty acid elongation	21873635.	IBA	Process
GO:0030497	fatty acid elongation	18554506.	IDA	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0042761	very long-chain fatty acid biosynthetic process	21873635.	IBA	Process
GO:0042761	very long-chain fatty acid biosynthetic process	18554506.	IDA	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0045070	positive regulation of viral genome replication	18160438.	IMP	Process
GO:0046726	positive regulation by virus of viral protein levels in host cell	18160438.	IMP	Process
GO:0102158	very-long-chain 3-hydroxyacyl-CoA dehydratase activity	-	IEA	Function
GO:0102343	3-hydroxy-arachidoyl-CoA dehydratase activity	-	IEA	Function
GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity	-	IEA	Function
GO:0102345	3-hydroxy-lignoceroyl-CoA dehydratase activity	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.