EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1565556875Missense_MutationnovelS114C0.22
BLCAchr1565570204Splice_SitenovelX258_splice0.29
BLCAchr1565554951SilentNAV65V0.28
BLCAchr1565572232Splice_Regionnovel0.09
BRCAchr15655766473'UTRnovel0.17
BRCAchr15655765043'UTRnovel0.52
CESCchr1565576357Frame_Shift_DelnovelK358Rfs*170.35
CESCchr15655766473'UTRnovel0.33
CESCchr1565570120SilentnovelI230I0.2
CESCchr1565576364Missense_MutationNAK358N0.39
CESCchr15655766043'UTRnovel0.37
CESCchr15655764893'UTRNA0.34
COADchr15655304995'UTRnovel0.36
COADchr1565576314Missense_MutationnovelN342H0.08
COADchr1565556737Splice_SitenovelX69_splice0.34
COADchr1565576351Missense_MutationnovelY354C0.08
COADchr1565554912SilentnovelD52D0.36
COADchr1565562796SilentNAG148G0.13
COADchr1565562864Missense_MutationNAR171Q0.24
COADchr1565576364Missense_MutationNAK358N0.19
COADchr1565556783SilentNAQ83Q0.17
COADchr1565556757Missense_MutationNAQ75K0.24
ESCAchr1565576357Frame_Shift_DelnovelK358Rfs*170.37
ESCAchr1565562877Missense_MutationnovelL175F0.24
ESCAchr1565564214Splice_SitenovelX178_splice0.16
ESCAchr1565554940Missense_Mutationrs186662742L62V0.11
ESCAchr1565572349Missense_MutationnovelL332P0.35
ESCAchr15655779843'UTRnovel0.52
GBMchr1565562824Missense_MutationnovelF158I0.09
GBMchr1565564321Silentrs770153021P213P0.23
HNSCchr1565572280Missense_Mutationrs768554778R309Q0.09
KIRPchr15655306245'UTRnovel0.35
LGGchr1565554939SilentnovelF61F0.32
LIHCchr1565556847Missense_MutationnovelP105S0.18
LIHCchr15655305165'UTRnovel0.6
LUADchr1565554894SilentnovelG46G0.12
MESOchr1565572352Frame_Shift_InsnovelM334Nfs*150.25
OVchr1565562803Missense_Mutationrs781348893F151L0.18
OVchr1565570107Missense_MutationnovelF226S0.06
OVchr1565558732Splice_SitenovelX141_splice0.06
PAADchr1565530632Translation_Start_SiteNAM1?0.4
PRADchr1565576320Missense_Mutationrs769410818R344C0.28
READchr1565556873SilentNAE113E0.39
SKCMchr1565570183Nonsense_MutationNAW251*0.3
SKCMchr1565558715Silentrs372958001S135S0.6
SKCMchr1565564320Missense_Mutationrs570046325P213L0.62
STADchr1565576357Frame_Shift_DelnovelK358Rfs*170.19
STADchr1565571613Missense_Mutationrs756832499T280I0.41
STADchr1565564314Missense_Mutationrs778632006T211M0.1
UCECchr15655764603'UTRnovel0.5
UCECchr1565570195Missense_MutationNAE255D0.37
UCECchr1565572296Silentrs776091890L314L0.37
UCECchr15655766133'UTRnovel0.33
UCECchr15655764613'UTRnovel0.58
UCECchr15655778053'UTRnovel0.32
UCECchr1565556860Missense_Mutationrs757902811R109H0.41
UCECchr1565570103Missense_MutationnovelN225H0.05
UCECchr15655763873'UTRnovel0.21
UCECchr15655764323'UTRnovel0.15
UCECchr15655764613'UTRnovel0.27
UCECchr1565572359SilentnovelI335I0.13
UCECchr15655764293'UTRnovel0.3
UCECchr1565576348Missense_Mutationrs199662967R353H0.48
UCECchr1565564320Missense_Mutationrs570046325P213L0.38
UCECchr1565564214Splice_SitenovelX178_splice0.34
UCECchr15655764833'UTRnovel0.33
UCECchr1565554907Nonsense_MutationnovelG51*0.4
UCECchr1565562879Frame_Shift_InsnovelE178Rfs*50.52
UCECchr1565572329SilentNAS325S0.38
UCECchr1565576367Missense_MutationNAK359N0.49
UCECchr1565571606Missense_Mutationrs143107393R278C0.36
UCECchr1565556786Missense_MutationnovelK84N0.43
UCECchr1565572272Missense_MutationnovelE306D0.23
UCECchr1565562816Missense_MutationNAL155R0.12
UCECchr1565570117SilentnovelF229F0.47
UCECchr1565572276Missense_Mutationrs151201949G308R0.39

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KICHAMP0.27270.21756
LGGAMP0.01750.19963
PAADAMP0.06520.20695
PAADDEL0.11410.13216

Survival Analysis
CancerP-value Q-value
KIRC0.0011

Kaplan-Meier Survival Analysis

SARC0.01

Kaplan-Meier Survival Analysis

MESO0.021

Kaplan-Meier Survival Analysis

ACC0.0085

Kaplan-Meier Survival Analysis

HNSC0.009

Kaplan-Meier Survival Analysis

BRCA0.043

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

READ0.038

Kaplan-Meier Survival Analysis

LGG0.044

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000074696 (Gene tree)
Gene ID
51495
Gene Symbol
HACD3
Alias
B-ind1|HSPC121|PTPLAD1
Full Name
3-hydroxyacyl-CoA dehydratase 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
47,938 bases
Position
chr15:65,530,418-65,578,355
Accession
24175
RBP type
non-canonical RBP
Summary
(3-Hydroxyacyl-CoA Dehydratase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include enzyme binding and lyase activity. An important paralog of this gene is HACD4.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000562901HACD3-2051797-ENSP00000455686245 (aa)-H3BRL8
ENST00000568793HACD3-2101824-ENSP00000455530337 (aa)-H3BPZ1
ENST00000565299HACD3-2061465-ENSP00000456568400 (aa)-H3BS72
ENST00000562832HACD3-204789-ENSP00000454610139 (aa)-H3BMZ1
ENST00000566239HACD3-208393--- (aa)--
ENST00000566511HACD3-2091782-ENSP00000455587245 (aa)-H3BRL8
ENST00000261875HACD3-2013228-ENSP00000261875362 (aa)-Q9P035
ENST00000569894HACD3-2111471-ENSP00000454873245 (aa)-H3BRL8
ENST00000566074HACD3-2071658XM_011521664ENSP00000456300245 (aa)XP_011519966H3BRL8
ENST00000442729HACD3-2021332-ENSP00000392491307 (aa)-Q9P035
ENST00000624437HACD3-2122746--- (aa)--
ENST00000561763HACD3-203483--- (aa)--
Gene Model
Click here to download ENSG00000074696's gene model file
Pathways
Pathway IDPathway NameSource
hsa00062Fatty acid elongationKEGG
hsa01040Biosynthesis of unsaturated fatty acidsKEGG
hsa01100Metabolic pathwaysKEGG
hsa01212Fatty acid metabolismKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000074696rs129163601565564467TIntelligence (MTAG)29326435[0.016-0.034] unit increase0.025131594EFO_0004337
ENSG00000074696rs24560151565538180TMean corpuscular hemoglobin concentration27863252[0.017-0.033] unit increase0.02469321EFO_0004528
ENSG00000074696rs284570121565555773?General cognitive ability29844566z-score decrease4.556EFO_0004337
ENSG00000074696rs133802511565538681?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074696's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005096GTPase activator activity10747961.TASFunction
GO:0005515protein binding18160438.23935497.IPIFunction
GO:0005739mitochondrion-IDAComponent
GO:0005783endoplasmic reticulum18554506.IDAComponent
GO:0005789endoplasmic reticulum membrane-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0007249I-kappaB kinase/NF-kappaB signaling-IEAProcess
GO:0007257activation of JUN kinase activity10747961.TASProcess
GO:0007264small GTPase mediated signal transduction10747961.TASProcess
GO:0007266Rho protein signal transduction-IEAProcess
GO:0016021integral component of membrane-IEAComponent
GO:0016601Rac protein signal transduction10747961.NASProcess
GO:00188123-hydroxyacyl-CoA dehydratase activity21873635.IBAFunction
GO:00188123-hydroxyacyl-CoA dehydratase activity18554506.IDAFunction
GO:0019899enzyme binding18554506.IDAFunction
GO:0030148sphingolipid biosynthetic process21873635.IBAProcess
GO:0030497fatty acid elongation21873635.IBAProcess
GO:0030497fatty acid elongation18554506.IDAProcess
GO:0031965nuclear membrane-IDAComponent
GO:0042761very long-chain fatty acid biosynthetic process21873635.IBAProcess
GO:0042761very long-chain fatty acid biosynthetic process18554506.IDAProcess
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0045070positive regulation of viral genome replication18160438.IMPProcess
GO:0046726positive regulation by virus of viral protein levels in host cell18160438.IMPProcess
GO:0102158very-long-chain 3-hydroxyacyl-CoA dehydratase activity-IEAFunction
GO:01023433-hydroxy-arachidoyl-CoA dehydratase activity-IEAFunction
GO:01023443-hydroxy-behenoyl-CoA dehydratase activity-IEAFunction
GO:01023453-hydroxy-lignoceroyl-CoA dehydratase activity-IEAFunction
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