EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20174894Determination of cell proliferation using Mcm2 antigen and evaluation of apoptosis and TGF-beta1 expression in GH-secreting or clinically nonfunctioning pituitary adenomas.Endocr Pathol2010 MarDallago CMdoi: 10.1007/s12022-010-9107-x.
21866463Minichromosome maintenance 2 (MCM2) is a new prognostic proliferative marker in Wilms tumour.Pol J Pathol2011Taran K-
16882345Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer.BMC Cancer2006 Aug 1Yang J-
20694513MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.Dig Dis Sci2011 MarGiaginis Cdoi: 10.1007/s10620-010-1348-5
27065331Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a.Oncogene2016 Oct 13Liu Fdoi: 10.1038/onc.2016.80
21868526Correlation between expression of metallothionein and expression of Ki-67 and MCM-2 proliferation markers in non-small cell lung cancer.Anticancer Res2011 SepWerynska B-
18286467Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.J Cell Biochem2008 Jun 1Charych DHdoi: 10.1002/jcb.21698.
24706378Correlation of MCM2 detection with stage and virology of cervical cancer.Int J Biol Markers2014 Dec 9Amaro Filho SMdoi: 10.5301/jbm.5000081.
23329420MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer.Histol Histopathol2013 AprLiu Mdoi: 10.14670/HH-28.481
18465232Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.Dig Dis Sci2009 FebGiaginis Cdoi: 10.1007/s10620-008-0305-z
23770000MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells.Toxicol Lett2013 Jul 31Liu Ydoi: 10.1016/j.toxlet.2013.05.643
24630889MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies.Pathol Res Pract2014 JunJenson EGdoi: 10.1016/j.prp.2014.02.003
22554381Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 cases.Hum Pathol2012 NovToubaji Adoi: 10.1016/j.humpath.2012.01.007
19077563mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma.Eur J Cancer Prev2009 FebWang Ydoi: 10.1097/CEJ.0b013e32830c8d5a.
27748889MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder.Mol Med Rep2016 NovLiu Zdoi: 10.3892/mmr.2016.5851
29393493Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.Oncol Rep2018 AprZhong Adoi: 10.3892/or.2018.6229
28910940[Diagnostic value of p16/mcm2 dual staining in cervical intraepithelial neoplasia and its association with high-risk HPV infection].Zhonghua Liu Xing Bing Xue Za Zhi2017 Sep 10Wang HRdoi: 10.3760/cma.j.issn.0254-6450.2017.09.020.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr3127599417Missense_MutationnovelD36N0.38
BLCAchr3127604642Missense_MutationnovelE91K0.41
BLCAchr3127606691SilentNAV325V0.25
BLCAchr3127608862Missense_MutationNAD423N0.44
BLCAchr3127606768Missense_MutationNAS351F0.12
BLCAchr3127606299SilentnovelI285I0.14
BLCAchr3127616954Nonsense_MutationnovelE537*0.34
BRCAchr3127606204Nonsense_MutationNAE254*0.11
BRCAchr3127608417SilentNAQ379Q0.27
BRCAchr3127617988Silentrs777062602S640S0.13
CESCchr3127616997Missense_Mutationrs781253937A551V0.31
CESCchr3127604938Missense_Mutationrs200231306R152H0.22
CESCchr3127605136Missense_Mutationrs759341862R218H0.31
CESCchr3127606266Silentrs142980535Y274Y0.42
CESCchr3127608424Missense_Mutationrs771959565P382S0.42
CESCchr3127621743SilentnovelL895L0.21
CESCchr3127608978SilentnovelV461V0.18
COADchr3127604877IntronNA0.17
COADchr3127604637Missense_MutationnovelA89V0.36
COADchr3127619191Silentrs776426152Y726Y0.29
COADchr3127604969SilentNAE162E0.18
COADchr3127616933Missense_MutationnovelS530P0.11
COADchr3127621154Missense_MutationnovelV844M0.18
COADchr3127599423Missense_MutationNAL38I0.22
COADchr3127617392Silentrs141735401A629A0.66
COADchr3127599495Frame_Shift_DelnovelL63Wfs*400.12
COADchr3127615933Silentrs757903789F500F0.28
COADchr3127618062Missense_MutationNAD665V0.23
COADchr3127619039Missense_MutationNAA676S0.36
COADchr3127606718Silentrs376347464F334F0.17
ESCAchr3127606649SilentnovelV311V0.25
ESCAchr3127620767Missense_Mutationrs763364817R779C0.46
GBMchr3127606727SilentnovelG337G0.11
GBMchr3127599363Missense_Mutationrs775610133R18W0.4
GBMchr3127606718Silentrs376347464F334F0.44
GBMchr3127617353Silentrs755049339I616I0.2
GBMchr3127621100Missense_Mutationrs567419651R826C0.45
GBMchr3127621699Missense_MutationnovelY881D0.04
GBMchr3127599537Missense_MutationNAG76S0.39
HNSCchr3127619212Silentrs144817363P733P0.22
HNSCchr3127608391Nonsense_MutationNAQ371*0.24
HNSCchr3127619039Missense_MutationnovelA676T0.3
HNSCchr3127604920Missense_Mutationrs190889381R146H0.66
HNSCchr3127616954Missense_MutationnovelE537K0.07
HNSCchr3127605050Silentrs772343227A189A0.23
KIRCchr3127618073Missense_MutationnovelP669S0.09
KIRCchr3127606635Missense_MutationNAR307S0.36
KIRCchr3127619249Missense_MutationnovelM746L0.32
KIRPchr3127616962SilentnovelV539V0.28
LAMLchr3127605115Missense_MutationnovelG211D0.09
LAMLchr3127606289Missense_MutationnovelH282R0.76
LAMLchr3127608410Missense_Mutationrs774383866R377Q0.11
LAMLchr3127618037Missense_MutationnovelF657L0.19
LGGchr3127619047Silentrs763949869F678F0.15
LIHCchr3127604751Missense_MutationNAG127A0.12
LIHCchr3127618005Missense_MutationnovelN646S0.5
LIHCchr3127608449Missense_MutationnovelL390Q0.11
LUADchr3127606790Silentrs143514266A358A0.09
LUADchr3127599462Missense_MutationNAD51H0.33
LUADchr3127617380SilentnovelT625T0.11
LUADchr3127606680Missense_MutationnovelL322F0.07
LUADchr3127620727SilentnovelR765R0.09
LUADchr31275984075'UTRnovel0.3
LUADchr3127608987SilentnovelI464I0.37
LUADchr3127608988Missense_MutationnovelT465S0.37
LUADchr3127619061Missense_MutationNAH683R0.41
LUSCchr3127617374SilentnovelR623R0.14
LUSCchr3127604976Missense_Mutationrs566433714E165K0.23
LUSCchr3127619070Missense_MutationNAH686L0.55
LUSCchr3127616992Frame_Shift_DelnovelA551Rfs*420.17
LUSCchr31275984215'UTRnovel0.15
LUSCchr3127599399Nonsense_MutationnovelR30*0.21
LUSCchr3127616960Missense_MutationnovelV539L0.19
LUSCchr3127617100Silentrs780368141L585L0.12
LUSCchr3127608915SilentNAL440L0.27
LUSCchr3127608909SilentNAV438V0.16
LUSCchr3127621093SilentnovelS823S0.2
LUSCchr3127604951SilentnovelR156R0.19
LUSCchr3127606321Missense_MutationnovelE293Q0.17
LUSCchr31276217893'UTRnovel0.3
OVchr3127606233SilentNAA263A0.19
OVchr3127599422SilentnovelA37A0.22
OVchr3127621133Missense_MutationnovelK837Q0.17
OVchr3127599498SilentnovelL63L0.2
OVchr3127620754SilentnovelA774A0.29
OVchr3127599429Missense_MutationnovelS40P0.12
OVchr31276219483'UTRnovel0.12
OVchr3127619112Missense_MutationNAS700I0.48
PAADchr3127606294Missense_Mutationrs766530339R284C0.27
PAADchr3127599318Missense_MutationnovelE3K0.18
PAADchr3127621097Missense_Mutationrs771601773R825W0.18
PRADchr3127608512Missense_MutationnovelE411G0.42
PRADchr3127617341Silentrs753889372S612S0.21
PRADchr3127619113SilentnovelS700S0.29
READchr3127606718Silentrs376347464F334F0.28
READchr3127606796SilentNAP360P0.45
READchr3127615949Missense_MutationnovelN506H0.37
SARCchr3127604918Missense_MutationnovelE145D0.08
SKCMchr3127608967Missense_Mutationrs376973485D458N0.45
SKCMchr31276217763'UTRnovel0.24
SKCMchr3127606795Missense_MutationNAP360L0.08
SKCMchr3127606718Silentrs376347464F334F0.13
SKCMchr3127615933Missense_MutationNAF500L0.39
SKCMchr3127604916Missense_MutationNAE145K0.36
SKCMchr3127621759SilentNAL901L0.25
SKCMchr3127599383SilentNAL24L0.15
SKCMchr3127606773Missense_MutationnovelP353S0.28
SKCMchr3127620793Silentrs564548927I787I0.34
SKCMchr3127599337Missense_MutationNAT9I0.1
SKCMchr31275984595'UTRnovel0.37
SKCMchr31276217873'UTRnovel0.25
SKCMchr3127615933Silentrs757903789F500F0.49
SKCMchr3127617997SilentNAF643F0.41
SKCMchr3127620800Missense_Mutationrs369079696D790N0.28
SKCMchr3127615942SilentNAE503E0.06
SKCMchr3127605089SilentnovelF202F0.15
SKCMchr3127616919Missense_MutationNAP525L0.35
SKCMchr3127621183SilentnovelA853A0.49
SKCMchr3127617026Nonsense_MutationNAQ561*0.44
SKCMchr3127618013Missense_Mutationrs377424967L649F0.25
SKCMchr3127604921SilentnovelR146R0.24
SKCMchr3127621758Silentrs376562317I900I0.45
SKCMchr3127605006Missense_MutationNAE175K0.4
SKCMchr3127619265Missense_MutationnovelR751K0.32
STADchr3127606784SilentnovelQ356Q0.26
STADchr3127604617Silentrs186022338R82R0.25
STADchr3127620871Missense_MutationNAS813R0.35
STADchr3127604704SilentnovelE111E0.47
STADchr3127619145Missense_MutationnovelG711D0.36
STADchr3127604723Missense_MutationnovelR118W0.07
STADchr3127608487Missense_MutationNAV403M0.11
STADchr3127608908Missense_MutationNAV438D0.16
STADchr3127615953Missense_MutationNAP507R0.24
STADchr3127620866Missense_Mutationrs766565920R812C0.1
STADchr3127617018Missense_Mutationrs768309904A558V0.1
STADchr3127604976Missense_Mutationrs566433714E165K0.29
STADchr3127609014Silentrs757423043I473I0.23
STADchr3127617019Silentrs376837416A558A0.31
STADchr3127621173Missense_Mutationrs770365114R850H0.1
STADchr3127619220Missense_MutationNAN736S0.22
STADchr3127619212Silentrs144817363P733P0.12
STADchr3127621103Missense_MutationnovelD827N0.14
STADchr3127620876Missense_Mutationrs779228557R815H0.22
STADchr3127617089Nonsense_MutationNAG582*0.21
STADchr3127616997Missense_Mutationrs781253937A551V0.15
STADchr3127621167Missense_Mutationrs137990158R848H0.29
STADchr3127617068Missense_MutationNAA575T0.04
THCAchr3127604927SilentnovelA148A0.11
THCAchr3127616980SilentNAF545F0.37
THCAchr31276218223'UTRnovel0.13
UCECchr3127608925Missense_Mutationrs199539311V444M0.36
UCECchr3127606168Missense_Mutationrs201515306H242N0.39
UCECchr3127605120Missense_MutationnovelN213D0.33
UCECchr3127606667Silentrs150564590G317G0.4
UCECchr3127608886Missense_MutationnovelG431S0.45
UCECchr3127609015Missense_Mutationrs745669398G474R0.32
UCECchr3127608487Missense_MutationNAV403M0.14
UCECchr3127621097Missense_Mutationrs771601773R825W0.13
UCECchr3127619029Splice_Regionrs760568261D672D0.45
UCECchr31276218323'UTRnovel0.19
UCECchr3127608887Missense_MutationNAG431D0.44
UCECchr3127599452SilentNAP47P0.16
UCECchr3127621150Silentrs141996483E842E0.29
UCECchr3127604766Missense_Mutationrs201216288R132H0.27
UCECchr3127620733Silentrs575627406I767I0.15
UCECchr3127606227SilentNAE261E0.33
UCECchr3127608896Missense_MutationnovelV434D0.33
UCECchr3127610946Intronnovel0.13
UCECchr3127621698Missense_MutationnovelF880L0.2
UCECchr3127604761Silentrs745604668R130R0.29
UCECchr3127606329SilentnovelR295R0.33
UCECchr3127620820Silentrs761756992R796R0.22
UCECchr3127610848Intronnovel0.49
UCECchr3127599376Missense_MutationnovelD22G0.43
UCECchr3127608924SilentnovelH443H0.36
UCECchr3127620764Missense_Mutationrs772611484A778T0.7
UCECchr3127621101Missense_Mutationrs201882833R826H0.36
UCECchr3127619212Silentrs144817363P733P0.33
UCECchr3127620779Missense_Mutationrs757718055R783W0.48
UCECchr3127608481Missense_MutationNAD401Y0.34
UCECchr31275984605'UTRnovel0.3
UCECchr3127610897Intronnovel0.12
UCECchr3127618036SilentnovelR656R0.23
UCECchr3127604674SilentnovelD101D0.34
UCECchr3127620725Missense_MutationnovelR765W0.38
UCECchr3127599461Missense_MutationnovelE50D0.45
UCECchr3127606718Silentrs376347464F334F0.46
UCECchr3127620709Silentrs768741886S759S0.22
UCECchr3127620866Missense_Mutationrs766565920R812C0.24
UCECchr3127604957Silentrs369899498T158T0.31
UCECchr3127605075Missense_MutationnovelR198C0.2
UCECchr3127606249Missense_MutationNAA269T0.45
UCECchr3127616911Silentrs551643366C522C0.52
UCECchr3127620867Missense_Mutationrs185316647R812H0.45
UCECchr3127604929Missense_Mutationrs35343063R149H0.43
UCECchr3127604723Missense_MutationnovelR118W0.3
UCECchr3127605143Silentrs775245095S220S0.28
UCECchr3127616997Missense_Mutationrs781253937A551V0.26
UCECchr3127620859Silentrs371014572S809S0.28
UCECchr3127604703Missense_MutationnovelE111G0.24
UCECchr3127619244Missense_MutationnovelA744V0.43
UCECchr3127619164Missense_MutationnovelQ717H0.18
UCECchr3127617322Frame_Shift_DelnovelQ606Hfs*280.08
UCECchr3127604920Missense_Mutationrs190889381R146H0.48
UCECchr3127621092Nonsense_MutationNAS823*0.29
UCECchr3127617001Silentrs138708920S552S0.22
UCECchr3127620799Silentrs778858800D789D0.23
UCECchr3127617029Missense_Mutationrs767499238R562W0.28
UCECchr3127617979Silentrs774019407Y637Y0.37
UCECchr3127606634SilentNAI306I0.35
UCECchr3127608409Nonsense_MutationnovelR377*0.36
UCECchr3127615889Missense_MutationnovelY486H0.38
UCECchr3127617353Silentrs755049339I616I0.34
UCECchr3127620867Missense_Mutationrs185316647R812H0.48
UCSchr3127605053Frame_Shift_DelnovelR192Gfs*410.34
UCSchr3127617086Nonsense_MutationnovelR581*0.45

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
GBMDEL0.07630.00094652
KIRCDEL0.18370.11092
KIRPAMP0.31250.15981
LGGDEL0.06040.04374
PAADAMP0.09240.16151

Survival Analysis
CancerP-value Q-value
THYM0.016

Kaplan-Meier Survival Analysis

STAD0.0042

Kaplan-Meier Survival Analysis

SARC0.01

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

PRAD0.01

Kaplan-Meier Survival Analysis

KIRP0.00058

Kaplan-Meier Survival Analysis

PAAD0.0017

Kaplan-Meier Survival Analysis

PCPG0.016

Kaplan-Meier Survival Analysis

CESC0.0012

Kaplan-Meier Survival Analysis

READ0.048

Kaplan-Meier Survival Analysis

LAML0.0064

Kaplan-Meier Survival Analysis

KICH0.012

Kaplan-Meier Survival Analysis

UCEC0.0019

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.036

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

THCA0.041

Kaplan-Meier Survival Analysis

LUAD0.0028

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000073111 (Gene tree)
Gene ID
4171
Gene Symbol
MCM2
Alias
D3S3194|KIAA0030|BM28|cdc19|DFNA70|CCNL1|CDCL1
Full Name
minichromosome maintenance complex component 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
24,214 bases
Position
chr3:127,598,223-127,622,436
Accession
6944
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22538816KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing.Proc Natl Acad Sci U S A2012 May 22Ray Sdoi: 10.1073/pnas.1118515109
16226712Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.Biochem Biophys Res Commun2005 Dec 2Niture SK-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000468659MCM2-203557--- (aa)--
ENST00000474964MCM2-2062847-ENSP00000420007146 (aa)-F8WDM3
ENST00000468414MCM2-2021076--- (aa)--
ENST00000491422MCM2-2092844-ENSP00000420528836 (aa)-H0Y8E6
ENST00000473785MCM2-205684--- (aa)--
ENST00000472731MCM2-204547-ENSP00000418930103 (aa)-C9J013
ENST00000477668MCM2-2072510-ENSP0000041780091 (aa)-H7C4N9
ENST00000480910MCM2-208693-ENSP00000419802128 (aa)-C9JZ21
ENST00000265056MCM2-2013622XM_024453531ENSP00000265056904 (aa)XP_024309299P49736
Gene Model
Click here to download ENSG00000073111's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa04110Cell cycleKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000073111rs1441222123127621197TAlanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)28090653[1.32-50]7.692308EFO_0004735|EFO_0007965|EFO_0000220
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000073111's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000073111MCM29665.132FBgn0014861Mcm29864.367Drosophila_melanogaster
ENSG00000073111MCM26242.508FBgn0015929dpa5842.508Drosophila_melanogaster
ENSG00000073111MCM28340.556ENSG00000104738MCM48950.000Homo_sapiens
ENSG00000073111MCM27532.767YPR019WMCM46234.609Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000785chromatin16899510.IDAComponent
GO:0003677DNA binding8175912.TASFunction
GO:0003688DNA replication origin binding-IEAFunction
GO:0004386helicase activity-IEAFunction
GO:0005515protein binding11095689.12740381.15232106.15654075.16189514.16387653.16899510.17296731.19805216.19819239.19862764.21044950.21149733.22540012.23764002.24299456.25036637.25416956.26167883.26496610.27173435.28191891.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus16899510.21383955.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005664nuclear origin of replication recognition complex-IEAComponent
GO:0005730nucleolus21383955.IDAComponent
GO:0005737cytoplasm26196677.IDAComponent
GO:0006260DNA replication-TASProcess
GO:0006268DNA unwinding involved in DNA replication-IEAProcess
GO:0006270DNA replication initiation16899510.IMPProcess
GO:0006334nucleosome assembly-IEAProcess
GO:0006915apoptotic process26196677.IMPProcess
GO:0015630microtubule cytoskeleton-IDAComponent
GO:0019899enzyme binding-IEAFunction
GO:0042393histone binding-IEAFunction
GO:0042555MCM complex17296731.IDAComponent
GO:0046872metal ion binding-IEAFunction
GO:0071353cellular response to interleukin-4-IEAProcess
GO:0090102cochlea development26196677.IMPProcess
GO:1905775negative regulation of DNA helicase activity-IEAProcess
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