EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20174894	Determination of cell proliferation using Mcm2 antigen and evaluation of apoptosis and TGF-beta1 expression in GH-secreting or clinically nonfunctioning pituitary adenomas.	Endocr Pathol	2010 Mar	Dallago CM	doi: 10.1007/s12022-010-9107-x.
21866463	Minichromosome maintenance 2 (MCM2) is a new prognostic proliferative marker in Wilms tumour.	Pol J Pathol	2011	Taran K	-
16882345	Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer.	BMC Cancer	2006 Aug 1	Yang J	-
20694513	MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.	Dig Dis Sci	2011 Mar	Giaginis C	doi: 10.1007/s10620-010-1348-5
27065331	Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a.	Oncogene	2016 Oct 13	Liu F	doi: 10.1038/onc.2016.80
21868526	Correlation between expression of metallothionein and expression of Ki-67 and MCM-2 proliferation markers in non-small cell lung cancer.	Anticancer Res	2011 Sep	Werynska B	-
18286467	Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.	J Cell Biochem	2008 Jun 1	Charych DH	doi: 10.1002/jcb.21698.
24706378	Correlation of MCM2 detection with stage and virology of cervical cancer.	Int J Biol Markers	2014 Dec 9	Amaro Filho SM	doi: 10.5301/jbm.5000081.
23329420	MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer.	Histol Histopathol	2013 Apr	Liu M	doi: 10.14670/HH-28.481
18465232	Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.	Dig Dis Sci	2009 Feb	Giaginis C	doi: 10.1007/s10620-008-0305-z
23770000	MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells.	Toxicol Lett	2013 Jul 31	Liu Y	doi: 10.1016/j.toxlet.2013.05.643
24630889	MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies.	Pathol Res Pract	2014 Jun	Jenson EG	doi: 10.1016/j.prp.2014.02.003
22554381	Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 cases.	Hum Pathol	2012 Nov	Toubaji A	doi: 10.1016/j.humpath.2012.01.007
19077563	mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma.	Eur J Cancer Prev	2009 Feb	Wang Y	doi: 10.1097/CEJ.0b013e32830c8d5a.
27748889	MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder.	Mol Med Rep	2016 Nov	Liu Z	doi: 10.3892/mmr.2016.5851
29393493	Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.	Oncol Rep	2018 Apr	Zhong A	doi: 10.3892/or.2018.6229
28910940	[Diagnostic value of p16/mcm2 dual staining in cervical intraepithelial neoplasia and its association with high-risk HPV infection].	Zhonghua Liu Xing Bing Xue Za Zhi	2017 Sep 10	Wang HR	doi: 10.3760/cma.j.issn.0254-6450.2017.09.020.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	127599417	Missense_Mutation	novel	D36N	0.38
BLCA	chr3	127604642	Missense_Mutation	novel	E91K	0.41
BLCA	chr3	127606691	Silent	NA	V325V	0.25
BLCA	chr3	127608862	Missense_Mutation	NA	D423N	0.44
BLCA	chr3	127606768	Missense_Mutation	NA	S351F	0.12
BLCA	chr3	127606299	Silent	novel	I285I	0.14
BLCA	chr3	127616954	Nonsense_Mutation	novel	E537*	0.34
BRCA	chr3	127606204	Nonsense_Mutation	NA	E254*	0.11
BRCA	chr3	127608417	Silent	NA	Q379Q	0.27
BRCA	chr3	127617988	Silent	rs777062602	S640S	0.13
CESC	chr3	127616997	Missense_Mutation	rs781253937	A551V	0.31
CESC	chr3	127604938	Missense_Mutation	rs200231306	R152H	0.22
CESC	chr3	127605136	Missense_Mutation	rs759341862	R218H	0.31
CESC	chr3	127606266	Silent	rs142980535	Y274Y	0.42
CESC	chr3	127608424	Missense_Mutation	rs771959565	P382S	0.42
CESC	chr3	127621743	Silent	novel	L895L	0.21
CESC	chr3	127608978	Silent	novel	V461V	0.18
COAD	chr3	127604877	Intron	NA		0.17
COAD	chr3	127604637	Missense_Mutation	novel	A89V	0.36
COAD	chr3	127619191	Silent	rs776426152	Y726Y	0.29
COAD	chr3	127604969	Silent	NA	E162E	0.18
COAD	chr3	127616933	Missense_Mutation	novel	S530P	0.11
COAD	chr3	127621154	Missense_Mutation	novel	V844M	0.18
COAD	chr3	127599423	Missense_Mutation	NA	L38I	0.22
COAD	chr3	127617392	Silent	rs141735401	A629A	0.66
COAD	chr3	127599495	Frame_Shift_Del	novel	*L63Wfs40**	0.12
COAD	chr3	127615933	Silent	rs757903789	F500F	0.28
COAD	chr3	127618062	Missense_Mutation	NA	D665V	0.23
COAD	chr3	127619039	Missense_Mutation	NA	A676S	0.36
COAD	chr3	127606718	Silent	rs376347464	F334F	0.17
ESCA	chr3	127606649	Silent	novel	V311V	0.25
ESCA	chr3	127620767	Missense_Mutation	rs763364817	R779C	0.46
GBM	chr3	127606727	Silent	novel	G337G	0.11
GBM	chr3	127599363	Missense_Mutation	rs775610133	R18W	0.4
GBM	chr3	127606718	Silent	rs376347464	F334F	0.44
GBM	chr3	127617353	Silent	rs755049339	I616I	0.2
GBM	chr3	127621100	Missense_Mutation	rs567419651	R826C	0.45
GBM	chr3	127621699	Missense_Mutation	novel	Y881D	0.04
GBM	chr3	127599537	Missense_Mutation	NA	G76S	0.39
HNSC	chr3	127619212	Silent	rs144817363	P733P	0.22
HNSC	chr3	127608391	Nonsense_Mutation	NA	Q371*	0.24
HNSC	chr3	127619039	Missense_Mutation	novel	A676T	0.3
HNSC	chr3	127604920	Missense_Mutation	rs190889381	R146H	0.66
HNSC	chr3	127616954	Missense_Mutation	novel	E537K	0.07
HNSC	chr3	127605050	Silent	rs772343227	A189A	0.23
KIRC	chr3	127618073	Missense_Mutation	novel	P669S	0.09
KIRC	chr3	127606635	Missense_Mutation	NA	R307S	0.36
KIRC	chr3	127619249	Missense_Mutation	novel	M746L	0.32
KIRP	chr3	127616962	Silent	novel	V539V	0.28
LAML	chr3	127605115	Missense_Mutation	novel	G211D	0.09
LAML	chr3	127606289	Missense_Mutation	novel	H282R	0.76
LAML	chr3	127608410	Missense_Mutation	rs774383866	R377Q	0.11
LAML	chr3	127618037	Missense_Mutation	novel	F657L	0.19
LGG	chr3	127619047	Silent	rs763949869	F678F	0.15
LIHC	chr3	127604751	Missense_Mutation	NA	G127A	0.12
LIHC	chr3	127618005	Missense_Mutation	novel	N646S	0.5
LIHC	chr3	127608449	Missense_Mutation	novel	L390Q	0.11
LUAD	chr3	127606790	Silent	rs143514266	A358A	0.09
LUAD	chr3	127599462	Missense_Mutation	NA	D51H	0.33
LUAD	chr3	127617380	Silent	novel	T625T	0.11
LUAD	chr3	127606680	Missense_Mutation	novel	L322F	0.07
LUAD	chr3	127620727	Silent	novel	R765R	0.09
LUAD	chr3	127598407	5'UTR	novel		0.3
LUAD	chr3	127608987	Silent	novel	I464I	0.37
LUAD	chr3	127608988	Missense_Mutation	novel	T465S	0.37
LUAD	chr3	127619061	Missense_Mutation	NA	H683R	0.41
LUSC	chr3	127617374	Silent	novel	R623R	0.14
LUSC	chr3	127604976	Missense_Mutation	rs566433714	E165K	0.23
LUSC	chr3	127619070	Missense_Mutation	NA	H686L	0.55
LUSC	chr3	127616992	Frame_Shift_Del	novel	*A551Rfs42**	0.17
LUSC	chr3	127598421	5'UTR	novel		0.15
LUSC	chr3	127599399	Nonsense_Mutation	novel	R30*	0.21
LUSC	chr3	127616960	Missense_Mutation	novel	V539L	0.19
LUSC	chr3	127617100	Silent	rs780368141	L585L	0.12
LUSC	chr3	127608915	Silent	NA	L440L	0.27
LUSC	chr3	127608909	Silent	NA	V438V	0.16
LUSC	chr3	127621093	Silent	novel	S823S	0.2
LUSC	chr3	127604951	Silent	novel	R156R	0.19
LUSC	chr3	127606321	Missense_Mutation	novel	E293Q	0.17
LUSC	chr3	127621789	3'UTR	novel		0.3
OV	chr3	127606233	Silent	NA	A263A	0.19
OV	chr3	127599422	Silent	novel	A37A	0.22
OV	chr3	127621133	Missense_Mutation	novel	K837Q	0.17
OV	chr3	127599498	Silent	novel	L63L	0.2
OV	chr3	127620754	Silent	novel	A774A	0.29
OV	chr3	127599429	Missense_Mutation	novel	S40P	0.12
OV	chr3	127621948	3'UTR	novel		0.12
OV	chr3	127619112	Missense_Mutation	NA	S700I	0.48
PAAD	chr3	127606294	Missense_Mutation	rs766530339	R284C	0.27
PAAD	chr3	127599318	Missense_Mutation	novel	E3K	0.18
PAAD	chr3	127621097	Missense_Mutation	rs771601773	R825W	0.18
PRAD	chr3	127608512	Missense_Mutation	novel	E411G	0.42
PRAD	chr3	127617341	Silent	rs753889372	S612S	0.21
PRAD	chr3	127619113	Silent	novel	S700S	0.29
READ	chr3	127606718	Silent	rs376347464	F334F	0.28
READ	chr3	127606796	Silent	NA	P360P	0.45
READ	chr3	127615949	Missense_Mutation	novel	N506H	0.37
SARC	chr3	127604918	Missense_Mutation	novel	E145D	0.08
SKCM	chr3	127608967	Missense_Mutation	rs376973485	D458N	0.45
SKCM	chr3	127621776	3'UTR	novel		0.24
SKCM	chr3	127606795	Missense_Mutation	NA	P360L	0.08
SKCM	chr3	127606718	Silent	rs376347464	F334F	0.13
SKCM	chr3	127615933	Missense_Mutation	NA	F500L	0.39
SKCM	chr3	127604916	Missense_Mutation	NA	E145K	0.36
SKCM	chr3	127621759	Silent	NA	L901L	0.25
SKCM	chr3	127599383	Silent	NA	L24L	0.15
SKCM	chr3	127606773	Missense_Mutation	novel	P353S	0.28
SKCM	chr3	127620793	Silent	rs564548927	I787I	0.34
SKCM	chr3	127599337	Missense_Mutation	NA	T9I	0.1
SKCM	chr3	127598459	5'UTR	novel		0.37
SKCM	chr3	127621787	3'UTR	novel		0.25
SKCM	chr3	127615933	Silent	rs757903789	F500F	0.49
SKCM	chr3	127617997	Silent	NA	F643F	0.41
SKCM	chr3	127620800	Missense_Mutation	rs369079696	D790N	0.28
SKCM	chr3	127615942	Silent	NA	E503E	0.06
SKCM	chr3	127605089	Silent	novel	F202F	0.15
SKCM	chr3	127616919	Missense_Mutation	NA	P525L	0.35
SKCM	chr3	127621183	Silent	novel	A853A	0.49
SKCM	chr3	127617026	Nonsense_Mutation	NA	Q561*	0.44
SKCM	chr3	127618013	Missense_Mutation	rs377424967	L649F	0.25
SKCM	chr3	127604921	Silent	novel	R146R	0.24
SKCM	chr3	127621758	Silent	rs376562317	I900I	0.45
SKCM	chr3	127605006	Missense_Mutation	NA	E175K	0.4
SKCM	chr3	127619265	Missense_Mutation	novel	R751K	0.32
STAD	chr3	127606784	Silent	novel	Q356Q	0.26
STAD	chr3	127604617	Silent	rs186022338	R82R	0.25
STAD	chr3	127620871	Missense_Mutation	NA	S813R	0.35
STAD	chr3	127604704	Silent	novel	E111E	0.47
STAD	chr3	127619145	Missense_Mutation	novel	G711D	0.36
STAD	chr3	127604723	Missense_Mutation	novel	R118W	0.07
STAD	chr3	127608487	Missense_Mutation	NA	V403M	0.11
STAD	chr3	127608908	Missense_Mutation	NA	V438D	0.16
STAD	chr3	127615953	Missense_Mutation	NA	P507R	0.24
STAD	chr3	127620866	Missense_Mutation	rs766565920	R812C	0.1
STAD	chr3	127617018	Missense_Mutation	rs768309904	A558V	0.1
STAD	chr3	127604976	Missense_Mutation	rs566433714	E165K	0.29
STAD	chr3	127609014	Silent	rs757423043	I473I	0.23
STAD	chr3	127617019	Silent	rs376837416	A558A	0.31
STAD	chr3	127621173	Missense_Mutation	rs770365114	R850H	0.1
STAD	chr3	127619220	Missense_Mutation	NA	N736S	0.22
STAD	chr3	127619212	Silent	rs144817363	P733P	0.12
STAD	chr3	127621103	Missense_Mutation	novel	D827N	0.14
STAD	chr3	127620876	Missense_Mutation	rs779228557	R815H	0.22
STAD	chr3	127617089	Nonsense_Mutation	NA	G582*	0.21
STAD	chr3	127616997	Missense_Mutation	rs781253937	A551V	0.15
STAD	chr3	127621167	Missense_Mutation	rs137990158	R848H	0.29
STAD	chr3	127617068	Missense_Mutation	NA	A575T	0.04
THCA	chr3	127604927	Silent	novel	A148A	0.11
THCA	chr3	127616980	Silent	NA	F545F	0.37
THCA	chr3	127621822	3'UTR	novel		0.13
UCEC	chr3	127608925	Missense_Mutation	rs199539311	V444M	0.36
UCEC	chr3	127606168	Missense_Mutation	rs201515306	H242N	0.39
UCEC	chr3	127605120	Missense_Mutation	novel	N213D	0.33
UCEC	chr3	127606667	Silent	rs150564590	G317G	0.4
UCEC	chr3	127608886	Missense_Mutation	novel	G431S	0.45
UCEC	chr3	127609015	Missense_Mutation	rs745669398	G474R	0.32
UCEC	chr3	127608487	Missense_Mutation	NA	V403M	0.14
UCEC	chr3	127621097	Missense_Mutation	rs771601773	R825W	0.13
UCEC	chr3	127619029	Splice_Region	rs760568261	D672D	0.45
UCEC	chr3	127621832	3'UTR	novel		0.19
UCEC	chr3	127608887	Missense_Mutation	NA	G431D	0.44
UCEC	chr3	127599452	Silent	NA	P47P	0.16
UCEC	chr3	127621150	Silent	rs141996483	E842E	0.29
UCEC	chr3	127604766	Missense_Mutation	rs201216288	R132H	0.27
UCEC	chr3	127620733	Silent	rs575627406	I767I	0.15
UCEC	chr3	127606227	Silent	NA	E261E	0.33
UCEC	chr3	127608896	Missense_Mutation	novel	V434D	0.33
UCEC	chr3	127610946	Intron	novel		0.13
UCEC	chr3	127621698	Missense_Mutation	novel	F880L	0.2
UCEC	chr3	127604761	Silent	rs745604668	R130R	0.29
UCEC	chr3	127606329	Silent	novel	R295R	0.33
UCEC	chr3	127620820	Silent	rs761756992	R796R	0.22
UCEC	chr3	127610848	Intron	novel		0.49
UCEC	chr3	127599376	Missense_Mutation	novel	D22G	0.43
UCEC	chr3	127608924	Silent	novel	H443H	0.36
UCEC	chr3	127620764	Missense_Mutation	rs772611484	A778T	0.7
UCEC	chr3	127621101	Missense_Mutation	rs201882833	R826H	0.36
UCEC	chr3	127619212	Silent	rs144817363	P733P	0.33
UCEC	chr3	127620779	Missense_Mutation	rs757718055	R783W	0.48
UCEC	chr3	127608481	Missense_Mutation	NA	D401Y	0.34
UCEC	chr3	127598460	5'UTR	novel		0.3
UCEC	chr3	127610897	Intron	novel		0.12
UCEC	chr3	127618036	Silent	novel	R656R	0.23
UCEC	chr3	127604674	Silent	novel	D101D	0.34
UCEC	chr3	127620725	Missense_Mutation	novel	R765W	0.38
UCEC	chr3	127599461	Missense_Mutation	novel	E50D	0.45
UCEC	chr3	127606718	Silent	rs376347464	F334F	0.46
UCEC	chr3	127620709	Silent	rs768741886	S759S	0.22
UCEC	chr3	127620866	Missense_Mutation	rs766565920	R812C	0.24
UCEC	chr3	127604957	Silent	rs369899498	T158T	0.31
UCEC	chr3	127605075	Missense_Mutation	novel	R198C	0.2
UCEC	chr3	127606249	Missense_Mutation	NA	A269T	0.45
UCEC	chr3	127616911	Silent	rs551643366	C522C	0.52
UCEC	chr3	127620867	Missense_Mutation	rs185316647	R812H	0.45
UCEC	chr3	127604929	Missense_Mutation	rs35343063	R149H	0.43
UCEC	chr3	127604723	Missense_Mutation	novel	R118W	0.3
UCEC	chr3	127605143	Silent	rs775245095	S220S	0.28
UCEC	chr3	127616997	Missense_Mutation	rs781253937	A551V	0.26
UCEC	chr3	127620859	Silent	rs371014572	S809S	0.28
UCEC	chr3	127604703	Missense_Mutation	novel	E111G	0.24
UCEC	chr3	127619244	Missense_Mutation	novel	A744V	0.43
UCEC	chr3	127619164	Missense_Mutation	novel	Q717H	0.18
UCEC	chr3	127617322	Frame_Shift_Del	novel	*Q606Hfs28**	0.08
UCEC	chr3	127604920	Missense_Mutation	rs190889381	R146H	0.48
UCEC	chr3	127621092	Nonsense_Mutation	NA	S823*	0.29
UCEC	chr3	127617001	Silent	rs138708920	S552S	0.22
UCEC	chr3	127620799	Silent	rs778858800	D789D	0.23
UCEC	chr3	127617029	Missense_Mutation	rs767499238	R562W	0.28
UCEC	chr3	127617979	Silent	rs774019407	Y637Y	0.37
UCEC	chr3	127606634	Silent	NA	I306I	0.35
UCEC	chr3	127608409	Nonsense_Mutation	novel	R377*	0.36
UCEC	chr3	127615889	Missense_Mutation	novel	Y486H	0.38
UCEC	chr3	127617353	Silent	rs755049339	I616I	0.34
UCEC	chr3	127620867	Missense_Mutation	rs185316647	R812H	0.48
UCS	chr3	127605053	Frame_Shift_Del	novel	*R192Gfs41**	0.34
UCS	chr3	127617086	Nonsense_Mutation	novel	R581*	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.0763	0.00094652
KIRC	DEL	0.1837	0.11092
KIRP	AMP	0.3125	0.15981
LGG	DEL	0.0604	0.04374
PAAD	AMP	0.0924	0.16151

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
STAD	0.0042	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
PRAD	0.01	Kaplan-Meier Survival Analysis
KIRP	0.00058	Kaplan-Meier Survival Analysis
PAAD	0.0017	Kaplan-Meier Survival Analysis
PCPG	0.016	Kaplan-Meier Survival Analysis
CESC	0.0012	Kaplan-Meier Survival Analysis
READ	0.048	Kaplan-Meier Survival Analysis
LAML	0.0064	Kaplan-Meier Survival Analysis
KICH	0.012	Kaplan-Meier Survival Analysis
UCEC	0.0019	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.036	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
THCA	0.041	Kaplan-Meier Survival Analysis
LUAD	0.0028	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000073111 (Gene tree)
Gene ID: 4171
Gene Symbol: MCM2
Alias: D3S3194|KIAA0030|BM28|cdc19|DFNA70|CCNL1|CDCL1
Full Name: minichromosome maintenance complex component 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 24,214 bases
Position: chr3:127,598,223-127,622,436
Accession: 6944
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22538816	KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing.	Proc Natl Acad Sci U S A	2012 May 22	Ray S	doi: 10.1073/pnas.1118515109
16226712	Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.	Biochem Biophys Res Commun	2005 Dec 2	Niture SK	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468659	MCM2-203	557	-	-	- (aa)	-	-
ENST00000474964	MCM2-206	2847	-	ENSP00000420007	146 (aa)	-	F8WDM3
ENST00000468414	MCM2-202	1076	-	-	- (aa)	-	-
ENST00000491422	MCM2-209	2844	-	ENSP00000420528	836 (aa)	-	H0Y8E6
ENST00000473785	MCM2-205	684	-	-	- (aa)	-	-
ENST00000472731	MCM2-204	547	-	ENSP00000418930	103 (aa)	-	C9J013
ENST00000477668	MCM2-207	2510	-	ENSP00000417800	91 (aa)	-	H7C4N9
ENST00000480910	MCM2-208	693	-	ENSP00000419802	128 (aa)	-	C9JZ21
ENST00000265056	MCM2-201	3622	XM_024453531	ENSP00000265056	904 (aa)	XP_024309299	P49736

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa04110	Cell cycle	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000073111	rs144122212	3	127621197	T	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.32-50]	7.692308	EFO_0004735\|EFO_0007965\|EFO_0000220

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000073111's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000073111	MCM2	96	65.132	FBgn0014861	Mcm2	98	64.367	Drosophila_melanogaster
ENSG00000073111	MCM2	62	42.508	FBgn0015929	dpa	58	42.508	Drosophila_melanogaster
ENSG00000073111	MCM2	83	40.556	ENSG00000104738	MCM4	89	50.000	Homo_sapiens
ENSG00000073111	MCM2	75	32.767	YPR019W	MCM4	62	34.609	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000785	chromatin	16899510.	IDA	Component
GO:0003677	DNA binding	8175912.	TAS	Function
GO:0003688	DNA replication origin binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	11095689.12740381.15232106.15654075.16189514.16387653.16899510.17296731.19805216.19819239.19862764.21044950.21149733.22540012.23764002.24299456.25036637.25416956.26167883.26496610.27173435.28191891.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16899510.21383955.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005664	nuclear origin of replication recognition complex	-	IEA	Component
GO:0005730	nucleolus	21383955.	IDA	Component
GO:0005737	cytoplasm	26196677.	IDA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006268	DNA unwinding involved in DNA replication	-	IEA	Process
GO:0006270	DNA replication initiation	16899510.	IMP	Process
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006915	apoptotic process	26196677.	IMP	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0019899	enzyme binding	-	IEA	Function
GO:0042393	histone binding	-	IEA	Function
GO:0042555	MCM complex	17296731.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:0090102	cochlea development	26196677.	IMP	Process
GO:1905775	negative regulation of DNA helicase activity	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.