EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27826041	SMC1A recruits tumor-associated-fibroblasts (TAFs) and promotes colorectal cancer metastasis.	Cancer Lett	2017 Jan 28	Zhou P	doi: 10.1016/j.canlet.2016.10.041
23717600	Role of SMC1 in overcoming drug resistance in triple negative breast cancer.	PLoS One	2013 May 22	Yadav S	doi: 10.1371/journal.pone.0064338
26781859	SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.	Oncol Rep	2016 Apr	Li K	doi: 10.3892/or.2016.4564
26637483	Downregulation of SMC1A inhibits growth and increases apoptosis and chemosensitivity of colorectal cancer cells.	J Int Med Res	2016 Feb	Li J	doi: 10.1177/0300060515600188
25884313	Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer.	BMC Cancer	2015 Mar 4	Wang J	doi: 10.1186/s12885-015-1085-4.
27667360	SMC1A promotes growth and migration of prostate cancer in vitro and in vivo.	Int J Oncol	2016 Nov	Pan XW	doi: 10.3892/ijo.2016.3697
27739523	FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.	Sci Rep	2016 Oct 14	Fournier M	doi: 10.1038/srep34962.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	53413097	Silent	novel	A219A	0.15
ACC	chrX	53383203	Silent	novel	Q1008Q	0.29
ACC	chrX	53403849	Silent	novel	R747R	0.42
BLCA	chrX	53403609	Missense_Mutation	novel	E793K	0.67
BLCA	chrX	53380622	Missense_Mutation	novel	E1206K	0.47
BLCA	chrX	53403817	Missense_Mutation	novel	R758P	0.23
BLCA	chrX	53399676	Missense_Mutation	novel	K825N	0.55
BLCA	chrX	53415011	Missense_Mutation	novel	E90K	0.13
BLCA	chrX	53405657	Missense_Mutation	novel	E583K	0.8
BLCA	chrX	53414978	Splice_Region	novel		0.89
BLCA	chrX	53412037	Missense_Mutation	novel	E357D	0.96
BLCA	chrX	53412139	Missense_Mutation	novel	Q323H	0.93
BLCA	chrX	53382581	Silent	novel	F1070F	0.42
BLCA	chrX	53405609	Missense_Mutation	novel	R599C	1
BLCA	chrX	53414832	Nonsense_Mutation	novel	Q113*	0.27
BLCA	chrX	53405795	Silent	rs782653434	T569T	0.55
BLCA	chrX	53412039	Missense_Mutation	NA	E357K	0.31
BLCA	chrX	53421968	Intron	novel		0.5
BLCA	chrX	53405098	Missense_Mutation	novel	Q704E	0.7
BLCA	chrX	53409163	Nonsense_Mutation	NA	E482*	0.25
BLCA	chrX	53405657	Missense_Mutation	novel	E583Q	0.21
BLCA	chrX	53382270	Missense_Mutation	novel	K1133N	0.62
BRCA	chrX	53382276	Silent	NA	G1131G	0.16
BRCA	chrX	53382521	Silent	NA	R1090R	0.41
BRCA	chrX	53396293	Silent	NA	A932A	0.21
BRCA	chrX	53396294	Missense_Mutation	NA	A932D	0.21
BRCA	chrX	53412094	In_Frame_Del	NA	K338del	0.31
BRCA	chrX	53405034	Missense_Mutation	novel	R725Q	0.36
BRCA	chrX	53411873	Missense_Mutation	novel	E381V	0.04
BRCA	chrX	53412224	Missense_Mutation	NA	R295Q	0.36
BRCA	chrX	53396375	Missense_Mutation	NA	M905K	0.16
BRCA	chrX	53409193	Nonsense_Mutation	NA	E472*	0.11
BRCA	chrX	53409498	Missense_Mutation	novel	K420N	0.09
BRCA	chrX	53405523	Silent	NA	R627R	0.12
BRCA	chrX	53412240	Missense_Mutation	NA	E290Q	0.7
BRCA	chrX	53380646	Missense_Mutation	rs782175064	E1198K	0.07
BRCA	chrX	53411767	Missense_Mutation	novel	E416D	0.09
CESC	chrX	53403582	Missense_Mutation	NA	E802K	0.17
CESC	chrX	53382356	Missense_Mutation	novel	E1105Q	0.12
CESC	chrX	53380629	Silent	NA	V1203V	0.26
CESC	chrX	53411861	Missense_Mutation	NA	R385T	0.11
CESC	chrX	53412187	Missense_Mutation	novel	H307Q	0.38
CESC	chrX	53377236	3'UTR	novel		0.33
CESC	chrX	53422648	5'UTR	rs781826518		0.41
CESC	chrX	53412247	In_Frame_Del	novel	K287del	0.26
CESC	chrX	53404901	Intron	novel		0.38
CESC	chrX	53411799	Missense_Mutation	NA	R406C	0.37
CESC	chrX	53412905	Missense_Mutation	novel	E283D	0.35
CESC	chrX	53405017	Missense_Mutation	novel	L731V	0.1
CESC	chrX	53403663	Missense_Mutation	novel	E775K	0.23
CESC	chrX	53413023	Nonsense_Mutation	NA	S244*	0.18
CESC	chrX	53377779	3'UTR	novel		0.23
CESC	chrX	53377297	3'UTR	novel		0.27
CESC	chrX	53403604	Missense_Mutation	NA	E794D	0.14
CHOL	chrX	53377913	3'UTR	novel		0.25
COAD	chrX	53421910	Intron	novel		0.39
COAD	chrX	53405076	Missense_Mutation	rs782176647	R711L	0.5
COAD	chrX	53412117	Missense_Mutation	NA	G331C	0.42
COAD	chrX	53413261	Missense_Mutation	rs587784422	R196C	0.23
COAD	chrX	53380150	Missense_Mutation	novel	D1219N	0.78
COAD	chrX	53403590	Missense_Mutation	novel	R799Q	0.08
COAD	chrX	53405131	Missense_Mutation	novel	R693W	0.2
COAD	chrX	53405359	Silent	novel	K648K	0.42
COAD	chrX	53405527	Missense_Mutation	rs587784407	R626H	0.58
COAD	chrX	53380708	Missense_Mutation	novel	Q1177R	0.41
COAD	chrX	53412051	Missense_Mutation	rs781862992	R353W	0.69
COAD	chrX	53409482	Missense_Mutation	NA	R426W	0.44
COAD	chrX	53405355	Nonsense_Mutation	novel	G650*	0.29
COAD	chrX	53399599	Missense_Mutation	novel	K851T	0.33
COAD	chrX	53405362	Missense_Mutation	NA	Q647H	0.46
COAD	chrX	53413284	Missense_Mutation	NA	R188H	0.29
COAD	chrX	53409232	Silent	novel	L459L	0.21
COAD	chrX	53382613	Missense_Mutation	NA	E1060K	0.7
COAD	chrX	53413285	Missense_Mutation	NA	R188C	0.32
COAD	chrX	53412113	Missense_Mutation	novel	D332V	0.05
COAD	chrX	53409135	Missense_Mutation	NA	R491H	0.46
COAD	chrX	53412195	Missense_Mutation	novel	T305S	0.31
COAD	chrX	53409082	Missense_Mutation	NA	R509C	0.36
COAD	chrX	53379889	3'UTR	novel		0.32
GBM	chrX	53413059	In_Frame_Del	novel	N231_E232delinsK	0.42
GBM	chrX	53412899	Splice_Site	NA	X285_splice	0.33
GBM	chrX	53405390	Missense_Mutation	NA	T638K	0.89
GBM	chrX	53405827	Missense_Mutation	novel	Y559H	0.03
GBM	chrX	53422538	Missense_Mutation	novel	I21M	0.13
GBM	chrX	53412194	Missense_Mutation	NA	T305N	0.28
GBM	chrX	53405557	Missense_Mutation	novel	A616V	0.61
GBM	chrX	53409205	Missense_Mutation	novel	R468W	0.26
GBM	chrX	53412244	Silent	novel	D288D	0.3
GBM	chrX	53405660	Missense_Mutation	NA	D582Y	0.5
GBM	chrX	53409169	Missense_Mutation	novel	V480L	0.04
GBM	chrX	53403813	Missense_Mutation	novel	E759D	0.2
HNSC	chrX	53405608	Missense_Mutation	novel	R599H	0.7
HNSC	chrX	53412211	Missense_Mutation	novel	I299M	0.5
HNSC	chrX	53396344	Silent	novel	I915I	0.91
HNSC	chrX	53399595	Silent	novel	L852L	0.37
HNSC	chrX	53394811	Missense_Mutation	novel	E980D	0.14
HNSC	chrX	53415092	In_Frame_Del	novel	V58_R62del	0.25
KIRC	chrX	53403888	Frame_Shift_Del	novel	*K734Nfs8**	0.31
KIRP	chrX	53413352	Silent	NA	A165A	0.8
KIRP	chrX	53381064	Missense_Mutation	NA	V1154D	0.43
KIRP	chrX	53415085	In_Frame_Del	novel	I65del	0.3
LAML	chrX	53409147	Missense_Mutation	novel	A487G	1
LAML	chrX	53396617	Nonsense_Mutation	rs781935129	E855*	0.96
LAML	chrX	53382278	Missense_Mutation	NA	G1131R	0.1
LAML	chrX	53399704	Missense_Mutation	NA	R816H	0.15
LAML	chrX	53382311	Missense_Mutation	novel	K1120E	0.31
LGG	chrX	53413285	Missense_Mutation	NA	R188C	0.93
LGG	chrX	53405871	Missense_Mutation	novel	A544V	0.8
LGG	chrX	53396301	Silent	rs781912370	L930L	0.41
LGG	chrX	53399619	Silent	novel	K844K	0.24
LGG	chrX	53413306	Missense_Mutation	novel	D181N	0.31
LGG	chrX	53405500	Missense_Mutation	novel	R635L	0.71
LIHC	chrX	53415062	Missense_Mutation	novel	P73S	0.39
LIHC	chrX	53394833	Missense_Mutation	rs781980688	Y973C	0.47
LIHC	chrX	53380082	3'UTR	novel		0.38
LIHC	chrX	53382534	Missense_Mutation	NA	K1086M	0.24
LUAD	chrX	53405376	Missense_Mutation	novel	G643R	0.15
LUAD	chrX	53405275	Missense_Mutation	novel	E676D	0.22
LUAD	chrX	53396534	Silent	novel	S882S	0.19
LUAD	chrX	53412235	Silent	NA	L291L	0.35
LUAD	chrX	53409144	Missense_Mutation	NA	R488H	0.21
LUAD	chrX	53413326	Missense_Mutation	novel	E174A	0.21
LUAD	chrX	53382527	Silent	NA	L1088L	0.55
LUAD	chrX	53405839	Missense_Mutation	NA	D555N	0.18
LUAD	chrX	53396331	Missense_Mutation	novel	E920Q	0.18
LUAD	chrX	53382283	Missense_Mutation	NA	S1129L	0.34
LUSC	chrX	53412083	Missense_Mutation	NA	S342L	0.18
LUSC	chrX	53396261	Missense_Mutation	novel	S943L	0.06
LUSC	chrX	53396298	Missense_Mutation	novel	Q931E	0.56
LUSC	chrX	53409190	Missense_Mutation	novel	I473F	0.13
LUSC	chrX	53412155	Missense_Mutation	NA	S318F	0.36
LUSC	chrX	53412905	Missense_Mutation	novel	E283D	0.15
LUSC	chrX	53394872	Missense_Mutation	NA	E960G	0.75
LUSC	chrX	53405102	Missense_Mutation	novel	Q702H	0.67
OV	chrX	53412038	Missense_Mutation	novel	E357G	0.04
OV	chrX	53379889	3'UTR	novel		0.44
OV	chrX	53381057	Missense_Mutation	novel	D1156E	0.06
OV	chrX	53409133	Nonsense_Mutation	novel	*Q492Gfs4**	0.05
OV	chrX	53405660	Missense_Mutation	NA	D582Y	0.4
OV	chrX	53382593	Silent	novel	R1066R	0.2
OV	chrX	53405102	Missense_Mutation	NA	Q702H	0.26
OV	chrX	53383246	Missense_Mutation	novel	Q994P	0.43
OV	chrX	53383247	Missense_Mutation	novel	Q994K	0.41
OV	chrX	53413008	Missense_Mutation	NA	I249T	0.27
OV	chrX	53412184	Silent	novel	K308K	0.1
OV	chrX	53405139	Missense_Mutation	novel	K690T	0.12
OV	chrX	53405596	Missense_Mutation	novel	P603H	0.14
OV	chrX	53405389	Splice_Region	novel	T638T	0.13
OV	chrX	53382240	Silent	NA	A1143A	0.41
OV	chrX	53422503	Missense_Mutation	novel	P33H	0.22
OV	chrX	53409072	Missense_Mutation	NA	P512H	0.15
OV	chrX	53405856	Missense_Mutation	novel	S549L	0.05
OV	chrX	53396496	Missense_Mutation	NA	R895H	0.38
PAAD	chrX	53412931	Missense_Mutation	rs781812690	R275W	0.25
PRAD	chrX	53409082	Missense_Mutation	novel	R509G	0.15
READ	chrX	53411853	Missense_Mutation	NA	T388A	0.62
READ	chrX	53405519	Missense_Mutation	novel	A629T	0.12
READ	chrX	53405858	Silent	novel	D548D	0.29
READ	chrX	53409458	Missense_Mutation	NA	R434W	0.24
READ	chrX	53399626	Missense_Mutation	novel	V842A	0.06
SKCM	chrX	53380006	3'UTR	novel		1
SKCM	chrX	53409263	Silent	NA	S448S	1
SKCM	chrX	53396229	Frame_Shift_Del	novel	*E953Rfs10**	0.17
SKCM	chrX	53380013	3'UTR	novel		0.4
SKCM	chrX	53413068	Missense_Mutation	NA	Y229S	0.5
SKCM	chrX	53411870	Missense_Mutation	NA	A382G	0.83
SKCM	chrX	53394795	Silent	NA	L986L	0.2
SKCM	chrX	53409146	Silent	NA	A487A	0.81
SKCM	chrX	53405372	Missense_Mutation	novel	T644I	0.4
SKCM	chrX	53411822	Missense_Mutation	rs587784403	R398Q	0.78
STAD	chrX	53409481	Missense_Mutation	NA	R426Q	0.27
STAD	chrX	53394775	Splice_Region	novel		0.35
STAD	chrX	53405526	Silent	novel	R626R	0.18
STAD	chrX	53409121	Missense_Mutation	NA	R496C	0.27
STAD	chrX	53413388	Silent	NA	A153A	0.64
STAD	chrX	53413104	Missense_Mutation	NA	V217E	0.1
STAD	chrX	53411804	Missense_Mutation	NA	Q404R	0.19
STAD	chrX	53405655	Silent	novel	E583E	0.55
STAD	chrX	53405953	Missense_Mutation	NA	G517S	0.73
STAD	chrX	53383172	Missense_Mutation	NA	R1019C	0.64
STAD	chrX	53409177	Missense_Mutation	novel	L477P	0.07
STAD	chrX	53399634	Silent	NA	E839E	0.1
STAD	chrX	53411838	Silent	novel	L393L	0.72
THCA	chrX	53412055	Frame_Shift_Del	novel	*E352Nfs14**	0.06
THCA	chrX	53405895	Missense_Mutation	novel	K536R	0.12
UCEC	chrX	53403567	Missense_Mutation	novel	R807C	0.22
UCEC	chrX	53382250	Missense_Mutation	novel	L1140P	0.21
UCEC	chrX	53412051	Missense_Mutation	rs781862992	R353W	0.46
UCEC	chrX	53399613	Silent	NA	E846E	0.31
UCEC	chrX	53396479	Missense_Mutation	NA	A901T	0.48
UCEC	chrX	53403626	Missense_Mutation	rs782402477	R787H	0.35
UCEC	chrX	53409457	Missense_Mutation	NA	R434Q	0.07
UCEC	chrX	53415094	Missense_Mutation	novel	R62Q	0.09
UCEC	chrX	53382328	Missense_Mutation	NA	N1114S	0.32
UCEC	chrX	53396497	Missense_Mutation	novel	R895C	0.04
UCEC	chrX	53380646	Missense_Mutation	rs782175064	E1198K	0.32
UCEC	chrX	53377477	3'UTR	novel		0.44
UCEC	chrX	53405500	Missense_Mutation	NA	R635H	0.57
UCEC	chrX	53383126	Missense_Mutation	novel	V1034A	0.29
UCEC	chrX	53399665	Missense_Mutation	novel	K829R	0.11
UCEC	chrX	53405321	Missense_Mutation	novel	A661V	0.63
UCEC	chrX	53405054	Missense_Mutation	novel	D718E	0.23
UCEC	chrX	53380681	Missense_Mutation	rs587784419	V1186A	0.29
UCEC	chrX	53374882	3'UTR	novel		0.16
UCEC	chrX	53380080	3'UTR	novel		0.37
UCEC	chrX	53405076	Missense_Mutation	rs782176647	R711Q	0.52
UCEC	chrX	53409068	Silent	novel	G513G	0.34
UCEC	chrX	53409445	Missense_Mutation	novel	L438P	0.34
UCEC	chrX	53415063	Silent	novel	K72K	0.41
UCEC	chrX	53403800	Missense_Mutation	novel	D764Y	0.16
UCEC	chrX	53409210	Missense_Mutation	novel	A466V	0.23
UCEC	chrX	53382595	Missense_Mutation	rs797044896	R1066C	0.41
UCEC	chrX	53405865	Missense_Mutation	novel	I546S	0.51
UCEC	chrX	53412110	Missense_Mutation	novel	M333T	0.49
UCEC	chrX	53421975	Intron	novel		0.47
UCEC	chrX	53380705	Missense_Mutation	novel	S1178W	0.18
UCEC	chrX	53412959	Silent	novel	E265E	0.03
UCEC	chrX	53380640	Missense_Mutation	NA	L1200I	0.31
UCEC	chrX	53403792	Missense_Mutation	novel	K766N	0.04
UCEC	chrX	53382370	Missense_Mutation	NA	P1100H	0.25
UCEC	chrX	53413424	Frame_Shift_Ins	novel	*E141Dfs16**	0.05
UCEC	chrX	53413425	Nonsense_Mutation	novel	*E141Vfs4**	0.05
UCEC	chrX	53414848	Silent	novel	I107I	0.36
UCEC	chrX	53377855	3'UTR	novel		0.18
UCEC	chrX	53412069	Missense_Mutation	novel	R347W	0.29
UCEC	chrX	53413269	Missense_Mutation	NA	A193V	0.46
UCEC	chrX	53382646	Nonsense_Mutation	novel	R1049*	0.47
UCEC	chrX	53414831	Missense_Mutation	novel	Q113R	0.11
UCEC	chrX	53374873	3'UTR	novel		0.47
UCEC	chrX	53394802	Silent	novel	Y983Y	0.4
UCEC	chrX	53413007	Silent	NA	I249I	0.05
UCEC	chrX	53378015	3'UTR	novel		0.34
UCEC	chrX	53413280	Missense_Mutation	novel	K189N	0.18
UCEC	chrX	53403794	Missense_Mutation	novel	K766E	0.13
UCEC	chrX	53405131	Missense_Mutation	novel	R693W	0.3
UCEC	chrX	53405810	Silent	novel	R564R	0.39
UCEC	chrX	53412172	Silent	novel	L312L	0.33
UCEC	chrX	53374711	3'UTR	novel		0.19
UCEC	chrX	53405265	Missense_Mutation	novel	R680C	0.43
UCEC	chrX	53405659	Missense_Mutation	novel	D582G	0.17
UCEC	chrX	53409081	Missense_Mutation	NA	R509H	0.44
UCEC	chrX	53405113	Missense_Mutation	NA	R699C	0.36
UCEC	chrX	53376015	3'UTR	novel		0.25
UCEC	chrX	53413007	Silent	NA	I249I	0.41
UCEC	chrX	53381066	Silent	novel	F1153F	0.17
UCEC	chrX	53415055	Missense_Mutation	novel	A75V	0.34
UCEC	chrX	53380641	Silent	novel	S1199S	0.41
UCEC	chrX	53403608	Missense_Mutation	novel	E793G	0.08
UCEC	chrX	53409081	Missense_Mutation	NA	R509H	0.31
UCEC	chrX	53374660	3'UTR	rs375348750		0.34
UCEC	chrX	53374882	3'UTR	novel		0.4
UCEC	chrX	53382582	Missense_Mutation	novel	F1070S	0.54
UCEC	chrX	53405821	Nonsense_Mutation	novel	K561*	0.4
UCEC	chrX	53422650	5'UTR	novel		0.17
UCEC	chrX	53380084	3'UTR	rs782233428		0.37
UCEC	chrX	53381066	Silent	novel	F1153F	0.08
UCEC	chrX	53405500	Missense_Mutation	NA	R635H	0.5
UCEC	chrX	53412001	Missense_Mutation	NA	E369D	0.34
UCEC	chrX	53412225	Missense_Mutation	novel	R295W	0.04
UCEC	chrX	53413285	Missense_Mutation	NA	R188C	0.48
UCEC	chrX	53405027	Silent	novel	L727L	0.36
UCEC	chrX	53399703	Silent	novel	R816R	0.34
UCEC	chrX	53414992	Missense_Mutation	rs781817340	R96H	0.51
UCEC	chrX	53378022	3'UTR	novel		0.34
UCEC	chrX	53383112	Nonsense_Mutation	novel	Q1039*	0.47
UCEC	chrX	53403850	Missense_Mutation	NA	R747H	0.27
UCEC	chrX	53404905	Intron	novel		0.09
UCEC	chrX	53409458	Missense_Mutation	NA	R434W	0.43
UCEC	chrX	53405648	Missense_Mutation	NA	R586W	0.45
UCEC	chrX	53382308	Missense_Mutation	novel	R1121C	0.34
UCEC	chrX	53374775	3'UTR	novel		0.31
UCEC	chrX	53403642	Missense_Mutation	novel	R782W	0.26
UCEC	chrX	53382586	Missense_Mutation	novel	R1069C	0.43
UCEC	chrX	53405597	Missense_Mutation	novel	P603S	0.34
UCEC	chrX	53405263	Silent	novel	R680R	0.56
UCEC	chrX	53413241	Missense_Mutation	novel	E202D	0.43
UCEC	chrX	53413314	Missense_Mutation	NA	A178V	0.55
UCEC	chrX	53405494	Missense_Mutation	NA	K637R	0.44
UCEC	chrX	53396497	Missense_Mutation	novel	R895C	0.16
UCEC	chrX	53405077	Missense_Mutation	rs587784409	R711W	0.5
UCEC	chrX	53380682	Missense_Mutation	NA	V1186I	0.39
UCEC	chrX	53403618	Missense_Mutation	rs587784412	R790W	0.41
UCEC	chrX	53403661	Missense_Mutation	novel	E775D	0.09
UCEC	chrX	53412959	Missense_Mutation	novel	E265D	0.08
UCEC	chrX	53413002	Missense_Mutation	novel	K251R	0.39
UCEC	chrX	53422500	Missense_Mutation	NA	N34S	0.51
UCEC	chrX	53415110	Missense_Mutation	NA	R57W	0.23
UCEC	chrX	53413295	Missense_Mutation	NA	F184L	0.28
UCEC	chrX	53405076	Missense_Mutation	rs782176647	R711Q	0.28
UCEC	chrX	53382344	Missense_Mutation	novel	D1109N	0.37
UCEC	chrX	53405816	Missense_Mutation	novel	E562D	0.51
UCEC	chrX	53414868	Missense_Mutation	novel	G101C	0.32
UCEC	chrX	53394795	Missense_Mutation	novel	L986M	0.22
UCEC	chrX	53404813	Intron	novel		0.25
UCEC	chrX	53405954	Splice_Region	rs782547781	Y516Y	0.11
UCEC	chrX	53422015	Intron	NA		0.29
UCEC	chrX	53377316	3'UTR	novel		0.45
UCEC	chrX	53381066	Silent	novel	F1153F	0.43
UCEC	chrX	53394880	Silent	novel	S957S	0.43
UCEC	chrX	53403597	Missense_Mutation	novel	V797L	0.28
UCEC	chrX	53404898	Intron	novel		0.43
UCEC	chrX	53405524	Missense_Mutation	rs781857094	R627H	0.29
UCEC	chrX	53374883	3'UTR	novel		0.27
UCEC	chrX	53376132	3'UTR	novel		0.65
UCS	chrX	53405357	Missense_Mutation	novel	S649L	1
UCS	chrX	53405077	Missense_Mutation	rs587784409	R711W	0.84
UVM	chrX	53383144	Missense_Mutation	novel	M1028T	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.4444	0.089286
SARC	AMP	0.323	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
KIRC	0.0011	Kaplan-Meier Survival Analysis
STAD	0.0023	Kaplan-Meier Survival Analysis
SARC	0.0034	Kaplan-Meier Survival Analysis
MESO	0.00029	Kaplan-Meier Survival Analysis
READ	0.042	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000072501 (Gene tree)
Gene ID: 8243
Gene Symbol: SMC1A
Alias: DXS423E|KIAA0178|SB1.8|Smcb|SMC1L1
Full Name: structural maintenance of chromosomes 1A
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 48,580 bases
Position: chrX:53,374,149-53,422,728
Accession: 11111
Summary: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469129	SMC1A-205	847	-	-	- (aa)	-	-
ENST00000375340	SMC1A-202	9930	-	ENSP00000364489	1211 (aa)	-	G8JLG1
ENST00000428014	SMC1A-203	868	-	ENSP00000413509	262 (aa)	-	H0Y7K8
ENST00000470241	SMC1A-206	838	-	ENSP00000476416	279 (aa)	-	V9GY57
ENST00000322213	SMC1A-201	9784	-	ENSP00000323421	1233 (aa)	-	Q14683
ENST00000463684	SMC1A-204	880	-	ENSP00000476958	54 (aa)	-	V9GYN9

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072501's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000072501	SMC1A	100	99.838	ENSMUSG00000041133	Smc1a	100	99.838	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	7757074.	TAS	Process
GO:0000775	chromosome, centromeric region	-	TAS	Component
GO:0000776	kinetochore	11682612.12199140.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000794	condensed nuclear chromosome	7757074.	TAS	Component
GO:0003682	chromatin binding	11076961.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	11076961.11590136.11877377.12930902.15837422.16438930.17112726.17113138.17349791.18832153.19629043.20818333.22628566.22885700.22977523.23242214.24136289.26496610.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	11076961.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	11877377.	TAS	Process
GO:0007062	sister chromatid cohesion	15917200.	IMP	Process
GO:0007064	mitotic sister chromatid cohesion	12199140.	TAS	Process
GO:0008278	cohesin complex	11590136.22628566.	IDA	Component
GO:0008278	cohesin complex	11076961.	TAS	Component
GO:0009314	response to radiation	11877377.	IEP	Process
GO:0016363	nuclear matrix	11590136.	IDA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030893	meiotic cohesin complex	21242291.	IDA	Component
GO:0032876	negative regulation of DNA endoreduplication	15917200.	IMP	Process
GO:0036033	mediator complex binding	-	IEA	Function
GO:0046982	protein heterodimerization activity	11590136.	IPI	Function
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	-	ISS	Process
GO:0072423	response to DNA damage checkpoint signaling	11877377.	IDA	Process
GO:0097431	mitotic spindle pole	11590136.	IDA	Component
GO:1901673	regulation of mitotic spindle assembly	11590136.	IMP	Process

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.