EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18353764Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.Mol Cell Proteomics2008 JulThorsen Kdoi: 10.1074/mcp.M700590-MCP200
21408150HAMLET binding to α-actinin facilitates tumor cell detachment.PLoS One2011 Mar 8Trulsson Mdoi: 10.1371/journal.pone.0017179.
18978946ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma.PLoS One2008Yoon KJdoi: 10.1371/journal.pone.0003629
29742177Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer.PLoS One2018 May 9Kovac Bdoi: 10.1371/journal.pone.0196986

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1468882887Missense_MutationnovelG602S0.29
ACCchr1468904700Missense_Mutationrs770793826V211M0.1
BLCAchr1468904658Missense_Mutationrs387907350E225K0.06
BLCAchr1468884215Nonsense_MutationnovelE530*0.35
BLCAchr1468892238Missense_MutationnovelV301L0.1
BLCAchr14689790815'UTRnovel0.21
BLCAchr1468925609Missense_MutationnovelE57K0.15
BLCAchr14688748523'UTRnovel0.06
BLCAchr1468921009Missense_Mutationrs752533755E113K0.22
BLCAchr1468877216Missense_MutationnovelM796L0.24
BLCAchr1468902490Missense_MutationnovelS250C0.23
BLCAchr1468879963Missense_Mutationrs757704267R760Q0.27
BRCAchr1468875004Missense_MutationNAM845T0.31
BRCAchr1468882911Missense_MutationNAT594A0.23
BRCAchr1468877148SilentNAR818R0.37
BRCAchr1468879040Silentrs1054225E770E0.13
BRCAchr1468921070Silentrs780296951N92N0.47
CESCchr1468884266Missense_MutationnovelE513Q0.37
CESCchr1468874988SilentnovelR850R0.11
CESCchr1468882526Nonsense_MutationNAE629*0.42
CESCchr1468887820Intronnovel0.28
CESCchr1468877199SilentnovelP801P0.32
COADchr1468880071Missense_MutationNAI724S0.3
COADchr1468878500Intronnovel0.44
COADchr1468884308Missense_Mutationrs372651589R499W0.38
COADchr14689791025'UTRnovel0.13
COADchr1468878528Intronnovel0.1
COADchr1468892149In_Frame_DelnovelE330del0.05
COADchr1468880102Missense_MutationNAR714C0.34
COADchr1468921016Silentrs144795702I110I0.19
COADchr1468912228Frame_Shift_InsnovelN119Efs*30.38
COADchr1468878553Intronnovel0.58
COADchr1468887938Intronnovel0.47
COADchr1468874952SilentNAA862A0.38
COADchr1468874990Missense_Mutationrs148344567R850C0.49
COADchr1468879964Missense_Mutationrs781540049R760W0.33
COADchr1468878490Intronrs3777662890.1
COADchr1468874992Missense_Mutationrs371440985R849H0.2
COADchr1468879008Missense_MutationNAD781G0.27
COADchr1468874991Silentrs768105419R849R0.14
COADchr1468902474Splice_Regionnovel0.15
COADchr1468887614Intronnovel0.57
COADchr1468887987Intronnovel0.2
COADchr1468880069Missense_Mutationrs201419872A725T0.26
COADchr1468925599Missense_Mutationrs750397684R60Q0.23
GBMchr1468890174Missense_Mutationrs575011573R400Q0.48
GBMchr1468882508Missense_MutationnovelF635L0.06
GBMchr1468925574SilentnovelL68L0.58
GBMchr1468880822Missense_MutationnovelN707K0.05
GBMchr1468874904Silentrs141668847D878D0.25
GBMchr1468882906SilentNAI595I0.14
HNSCchr1468879046Silentrs768216429P768P0.38
HNSCchr1468878487Intronrs3715363760.4
HNSCchr14688748513'UTRrs7748075080.15
HNSCchr1468877195Missense_MutationnovelR803S0.31
HNSCchr1468885487Missense_MutationnovelE441D0.61
HNSCchr1468878521Intronnovel0.59
KIRCchr1468887873Intronnovel0.25
KIRCchr1468890249Missense_MutationNAE375A0.28
KIRCchr1468882554SilentNAT619T0.27
KIRCchr14689791585'UTRnovel0.45
KIRCchr1468887970Intronnovel0.3
KIRPchr1468885422Splice_Regionnovel0.4
LGGchr1468887782Intronnovel0.49
LGGchr1468902497Missense_Mutationrs761658735A248T0.27
LIHCchr1468884255Missense_MutationNAK516N0.9
LIHCchr1468884257Missense_MutationNAK516E0.9
LIHCchr1468892120Missense_MutationNAT340M0.12
LUADchr1468882554SilentNAT619T0.24
LUADchr1468878470Intronnovel0.3
LUADchr1468882921Missense_MutationnovelN590K0.17
LUADchr1468912185Missense_MutationNAR133L0.26
LUADchr1468890244Missense_MutationnovelG377C0.3
LUADchr1468879998Missense_MutationnovelM748I0.24
LUADchr1468910041Missense_MutationNAE143D0.49
LUADchr1468887929Intronnovel0.22
LUADchr1468880849SilentNAA698A0.37
LUADchr1468875005Missense_Mutationrs766310248M845V0.3
LUADchr1468979020Missense_Mutationrs774738700M13V0.4
LUADchr14688747973'UTRnovel0.44
LUADchr1468880924Silentrs139138798Q673Q0.11
LUSCchr14688748043'UTRnovel0.4
LUSCchr1468904736Missense_MutationnovelD199H0.21
LUSCchr1468878889Intronnovel0.24
LUSCchr1468921119Missense_Mutationrs770910449R76H0.3
LUSCchr1468880041Missense_MutationNAQ734R0.16
LUSCchr1468880988Missense_MutationnovelE652V0.25
OVchr1468890284Frame_Shift_InsnovelI364Pfs*210.04
OVchr1468890285Nonsense_MutationnovelD363Afs*50.04
OVchr1468902546SilentnovelA231A0.48
OVchr1468885805Intronnovel0.67
OVchr1468912240Frame_Shift_InsnovelI115Afs*70.1
OVchr1468925641Missense_Mutationrs387907348R46Q0.29
OVchr1468921107Missense_MutationnovelP80L0.89
OVchr1468921108Nonsense_MutationnovelP80Kfs*40.89
OVchr1468885575Missense_MutationnovelG412V0.13
PAADchr1468878792Intronnovel0.13
PAADchr1468892255Missense_Mutationrs747970717P295L0.17
PRADchr1468874883SilentnovelA885A0.35
PRADchr1468878488Intronrs3747480720.21
PRADchr1468878931Intronnovel0.07
READchr1468921051Missense_MutationnovelF99V0.26
READchr1468879045Missense_MutationnovelE769K0.38
READchr1468883024Missense_MutationNAA556V0.28
READchr1468887684Intronnovel0.19
READchr1468878917Intronnovel0.42
READchr1468884302Missense_Mutationrs368356125E501K0.27
READchr1468884300SilentNAE501E0.37
READchr1468912185Missense_MutationNAR133H0.32
READchr1468887747Intronnovel0.23
SARCchr1468887761Intronnovel0.45
SKCMchr1468878924Intronnovel0.06
SKCMchr14688747203'UTRnovel0.57
SKCMchr1468888099Intronnovel0.29
SKCMchr1468880984Silentrs372031019I653I0.18
SKCMchr1468904677SilentNAI218I0.2
SKCMchr1468880103SilentNAI713I0.36
SKCMchr1468874922SilentNAS872S0.35
SKCMchr1468885493SilentNAA439A0.2
SKCMchr1468909978SilentNAV164V0.29
SKCMchr1468921058SilentNAA96A0.24
SKCMchr1468904655Missense_MutationNAD226N0.27
SKCMchr1468902495Silentrs774184505A248A0.29
SKCMchr1468874923Missense_Mutationrs745859336S872F0.42
SKCMchr1468892076Missense_MutationNAP355S0.36
SKCMchr1468878391Intronnovel0.45
SKCMchr1468904674SilentNAP219P0.38
SKCMchr1468885424Splice_SiteNAX462_splice0.27
SKCMchr1468878589Intronnovel0.24
SKCMchr1468880826Missense_Mutationrs373795472T706I0.81
SKCMchr1468878924Intronnovel0.74
SKCMchr1468885616Intronnovel0.39
SKCMchr1468902490Missense_MutationNAS250F0.34
SKCMchr1468912212Missense_MutationNAL124Q0.22
SKCMchr1468874923Missense_Mutationrs745859336S872F0.48
SKCMchr14688747773'UTRnovel0.7
SKCMchr14688747593'UTRnovel0.65
SKCMchr1468882522Missense_MutationnovelR630K0.65
SKCMchr1468892188SilentNAR317R0.18
SKCMchr1468879039Missense_MutationnovelF771L0.06
STADchr14688748053'UTRnovel0.25
STADchr1468978961SilentnovelQ32Q0.28
STADchr1468925592SilentNAG62G0.19
STADchr1468887937Intronnovel0.26
STADchr1468925641Missense_Mutationrs387907348R46Q0.26
STADchr1468921064Silentrs137965016N94N0.42
STADchr14688747143'UTRnovel0.38
STADchr1468887918Intronnovel0.44
STADchr1468874953Missense_Mutationrs199901015A862V0.1
STADchr1468892254Silentrs139710798P295P0.15
STADchr1468878931Intronnovel0.23
STADchr1468882574Missense_MutationNAR613W0.11
STADchr1468880843Silentrs577992605I700I0.38
STADchr1468880872Missense_Mutationrs763573834D691N0.32
STADchr1468892191SilentNAF316F0.24
STADchr1468902516Silentrs149168564Y241Y0.14
STADchr14688747033'UTRnovel0.2
STADchr1468892164Silentrs774117795P325P0.08
STADchr1468880850Missense_MutationNAA698V0.26
STADchr1468892166Missense_MutationNAP325S0.2
STADchr1468902557Missense_Mutationrs151249499V228I0.5
UCECchr1468921032Missense_MutationnovelV105A0.08
UCECchr1468909323Missense_MutationNAR197W0.32
UCECchr1468887536Intronnovel0.15
UCECchr1468921102Nonsense_MutationnovelR82*0.16
UCECchr1468888027Intronnovel0.36
UCECchr1468893673Silentrs751472888Y279Y0.33
UCECchr1468880960Silentrs149956838H661H0.26
UCECchr1468887613Intronnovel0.38
UCECchr1468880091Missense_MutationnovelW717C0.33
UCECchr1468979036SilentnovelQ7Q0.17
UCECchr1468885490Silentrs145749867F440F0.48
UCECchr1468912179Missense_MutationnovelA135V0.4
UCECchr1468887149Intronnovel0.25
UCECchr1468878808Intronnovel0.41
UCECchr1468890273Missense_MutationnovelA367D0.39
UCECchr1468892178Missense_Mutationrs771989409R321C0.26
UCECchr1468878687Intronnovel0.36
UCECchr1468882942Silentrs760876057H583H0.43
UCECchr1468887464Intronnovel0.49
UCECchr1468877226SilentNAF792F0.18
UCECchr1468884247Missense_Mutationrs150426921A519V0.24
UCECchr1468884830Missense_MutationnovelC480Y0.39
UCECchr1468887614Intronnovel0.41
UCECchr1468882519Missense_MutationNAL631P0.3
UCECchr1468925586Missense_MutationNAK64N0.46
UCECchr1468880030Missense_Mutationrs387907349R738W0.35
UCECchr14688746953'UTRnovel0.48
UCECchr1468904656Missense_MutationnovelE225D0.28
UCECchr1468877139Silentrs774599678A821A0.28
UCECchr1468880991Splice_SitenovelX652_splice0.22
UCECchr1468921019SilentnovelS109S0.28
UCECchr1468877201Missense_MutationnovelP801S0.23
UCECchr1468892197Missense_MutationnovelE314D0.38
UCECchr1468910044Splice_SitenovelX143_splice0.48
UCECchr1468979031Missense_MutationnovelT9I0.41
UCECchr14688745893'UTRnovel0.33
UCECchr1468893746Missense_Mutationrs773643865A255V0.28
UCECchr14688745333'UTRnovel0.38
UCECchr1468884275SilentnovelL510L0.35
UCECchr1468878598Intronnovel0.45
UCECchr1468878898Intronnovel0.38
UCECchr1468893662Missense_MutationnovelA283V0.09
UCECchr14688746623'UTRnovel0.32
UCECchr14688746673'UTRnovel0.3
UCECchr1468884867Missense_MutationnovelD468N0.21
UCECchr1468887614Intronnovel0.41
UCECchr1468877088SilentNAG838G0.24
UCECchr1468885461Missense_MutationNAR450H0.21
UCECchr1468887614Intronnovel0.21
UCECchr1468887401Intronnovel0.64
UCECchr14688748513'UTRrs7748075080.1
UCECchr1468874993Missense_Mutationrs547204209R849C0.38
UCECchr1468884826SilentnovelD481D0.11
UCECchr1468893660Missense_MutationnovelS284G0.22
UCECchr14688748033'UTRnovel0.2
UCECchr1468874993Missense_Mutationrs547204209R849C0.51
UCECchr1468878912Intronnovel0.18
UCECchr1468882517Missense_Mutationrs373084944R632C0.32
UCECchr1468887619Intronnovel0.48
UCECchr1468909323Missense_MutationNAR197W0.52
UCECchr1468921016Silentrs144795702I110I0.45
UCECchr1468874990Missense_Mutationrs148344567R850C0.13
UCECchr1468892215Silentrs765652494A308A0.53
UCECchr1468878514Intronnovel0.37
UCECchr1468882955Missense_MutationnovelV579D0.29
UCECchr1468912238Silentrs773658344I115I0.14
UCECchr1468882873Splice_RegionnovelH606H0.45
UCECchr1468893673Silentrs751472888Y279Y0.31
UCECchr1468925664SilentnovelT38T0.08
UCECchr1468874880SilentnovelL886L0.44
UCECchr1468880015Missense_MutationNAI743V0.32
UCECchr1468885496Missense_MutationnovelE438D0.31
UCECchr14688748173'UTRnovel0.4
UCECchr14688748363'UTRrs5453961880.14
UCECchr1468885439Silentrs150266512I457I0.24
UCECchr1468925612Missense_Mutationrs200613938E56K0.28
UCECchr1468884245Missense_MutationnovelP520S0.24
UCECchr1468921087Missense_MutationnovelV87L0.29
UCECchr1468925600Missense_MutationnovelR60W0.2
UCECchr14688746433'UTRnovel0.31
UCECchr1468887614Intronnovel0.56
UCECchr1468877195Missense_MutationnovelR803C0.32
UCECchr1468884792Nonsense_MutationNAR493*0.27
UCECchr1468887971Intronnovel0.31
UCECchr1468925655SilentNAC41C0.35
UCECchr1468877221Missense_MutationnovelR794H0.49
UCECchr1468892120Missense_MutationNAT340M0.39
UCECchr1468902529Missense_MutationnovelA237V0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.14440.19769
BRCADEL0.26946.1292e-10
CHOLDEL0.55560.00040262
COADDEL0.28820.050084
GBMDEL0.27385.7274e-07
KIRCDEL0.38070.0074281
KIRPDEL0.17010.085174
LGGDEL0.20471.1681e-13
MESODEL0.40230.088547
OVDEL0.47156.0694e-08
PAADDEL0.06520.11332
READDEL0.35760.189
SARCDEL0.28790.0013077

Survival Analysis
CancerP-value Q-value
KIRC0.045

Kaplan-Meier Survival Analysis

STAD0.0091

Kaplan-Meier Survival Analysis

MESO0.00017

Kaplan-Meier Survival Analysis

ACC0.0003

Kaplan-Meier Survival Analysis

HNSC0.00065

Kaplan-Meier Survival Analysis

SKCM0.045

Kaplan-Meier Survival Analysis

LUSC0.014

Kaplan-Meier Survival Analysis

ESCA0.025

Kaplan-Meier Survival Analysis

KIRP0.00024

Kaplan-Meier Survival Analysis

BLCA0.0031

Kaplan-Meier Survival Analysis

CESC0.0011

Kaplan-Meier Survival Analysis

LIHC0.0098

Kaplan-Meier Survival Analysis

LUAD0.0013

Kaplan-Meier Survival Analysis

UVM0.0031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000072110 (Gene tree)
Gene ID
87
Gene Symbol
ACTN1
Alias
N
Full Name
actinin alpha 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
105,318 bases
Position
chr14:68,874,123-68,979,440
Accession
163
RBP type
non-canonical RBP
Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000394419ACTN1-2033464XM_017021720ENSP00000377941914 (aa)XP_016877209P12814
ENST00000555075ACTN1-214828-ENSP00000452254251 (aa)-H0YJW3
ENST00000538545ACTN1-2052813-ENSP00000439828930 (aa)-P12814
ENST00000553779ACTN1-210530-ENSP0000045061885 (aa)-G3V2E8
ENST00000544964ACTN1-206891-ENSP00000444422297 (aa)-H7C5W8
ENST00000555616ACTN1-215919-ENSP00000450903238 (aa)-G3V2W4
ENST00000556083ACTN1-2164674--- (aa)--
ENST00000556343ACTN1-218274--- (aa)--
ENST00000556203ACTN1-217564--- (aa)--
ENST00000193403ACTN1-2013779XM_011537265ENSP00000193403892 (aa)XP_011535567P12814
ENST00000554508ACTN1-213585--- (aa)--
ENST00000553290ACTN1-207619-ENSP00000450625207 (aa)-H0YJ11
ENST00000556571ACTN1-221568-ENSP00000452423126 (aa)-G3V5M4
ENST00000438964ACTN1-2043043XM_017021727ENSP00000414272887 (aa)XP_016877216P12814
ENST00000553882ACTN1-2112636--- (aa)--
ENST00000376839ACTN1-2022824XM_011537266ENSP00000366035822 (aa)XP_011535568H9KV75
ENST00000553659ACTN1-209434-ENSP0000045108672 (aa)-G3V380
ENST00000553370ACTN1-208605-ENSP00000450925144 (aa)-G3V2X9
ENST00000556432ACTN1-219558--- (aa)--
ENST00000556433ACTN1-2201259-ENSP00000450764260 (aa)-G3V2N5
ENST00000554158ACTN1-212571--- (aa)--
Gene Model
Click here to download ENSG00000072110's gene model file
Pathways
Pathway IDPathway NameSource
hsa04510Focal adhesionKEGG
hsa04520Adherens junctionKEGG
hsa04530Tight junctionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05146AmoebiasisKEGG
hsa05203Viral carcinogenesisKEGG
hsa05322Systemic lupus erythematosusKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000072110Coronary Artery Disease8.8920000E-005-
ENSG00000072110Coronary Artery Disease8.0590000E-005-
ENSG00000072110Coronary Artery Disease7.9910000E-005-
ENSG00000072110Coronary Artery Disease5.2020000E-005-
ENSG00000072110Coronary Disease2.1020000E-005-
ENSG00000072110Platelet Function Tests1.9866100E-005-
ENSG00000072110Platelet Function Tests1.0886700E-005-
ENSG00000072110Platelet Function Tests1.3319700E-005-
ENSG00000072110Platelet Count1E-2826805783
ENSG00000072110Periodontitis4E-624024966
ENSG00000072110Cognition Disorders2E-626252872
ENSG00000072110Cognitive Dysfunction2E-626252872
ENSG00000072110Cognition Disorders9E-726252872
ENSG00000072110Cognitive Dysfunction9E-726252872
ENSG00000072110Smoking7E-619247474
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000072110rs20733071468875533TMean platelet volume27863252[0.033-0.047] unit decrease0.03994193EFO_0004584
ENSG00000072110rs1176726621468958750CMean platelet volume27863252[0.36-0.52] unit increase0.4413049EFO_0004584
ENSG00000072110rs120501611468893914TPeriodontitis (Mean PAL)24024966[0.040-0.100] unit increase0.07EFO_0000649
ENSG00000072110rs767454671468959672CCognitive decline rate in late mild cognitive impairment26252872[0.16-0.37] unit increase0.2634HP_0100543|EFO_0007710
ENSG00000072110rs767454671468959672CCognitive decline rate in late mild cognitive impairment26252872[0.16-0.38] unit increase0.2707HP_0100543|EFO_0007710
ENSG00000072110rs1176726621468958750TPlatelet count26805783[0.50-0.71] unit increase0.604EFO_0004309
ENSG00000072110rs22689831468941980?Smoking behavior19247474[NR]1.52EFO_0004318
ENSG00000072110rs178357691468886047TMosquito bite size28199695[0.042-0.104] unit increase0.0727107EFO_0008378
ENSG00000072110rs49026811468959900TEducational attainment (MTAG)30038396[0.0055-0.0113] unit decrease0.0084EFO_0004784
ENSG00000072110rs37841381468929672?Platelet count29403010[0.022-0.04] unit decrease novel0.03059EFO_0004309
ENSG00000072110rs1176726621468958750CPlatelet distribution width27863252[0.25-0.41] unit increase0.3333976EFO_0007984
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072110's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000072110ACTN1100100.000ENSMUSG00000015143Actn110099.215Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001725stress fiber11223950.IDAComponent
GO:0001726ruffle11223950.IDAComponent
GO:0002576platelet degranulation-TASProcess
GO:0003725double-stranded RNA binding21266579.IDAFunction
GO:0005178integrin binding7983147.IDAFunction
GO:0005178integrin binding11223950.IPIFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding10793131.11101506.12446711.14623081.16189514.16291744.16464232.20120020.25416956.25910212.26496610.26871637.30021884.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space16502470.HDAComponent
GO:0005737cytoplasm16464232.23434115.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005884actin filament23434115.24069336.IDAComponent
GO:0005886plasma membrane-IEAComponent
GO:0005903brush border-IEAComponent
GO:0005911cell-cell junction11223950.IDAComponent
GO:0005916fascia adherens-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion11223950.IDAComponent
GO:0005925focal adhesion16807302.IMPComponent
GO:0007015actin filament organization23434115.IMPProcess
GO:0017166vinculin binding11223950.IDAFunction
GO:0017166vinculin binding15988023.IPIFunction
GO:0030018Z disc-IEAComponent
GO:0030168platelet activation24069336.IMPProcess
GO:0030220platelet formation23434115.IMPProcess
GO:0030374nuclear receptor transcription coactivator activity22351778.IDAFunction
GO:0031093platelet alpha granule lumen-TASComponent
GO:0031143pseudopodium1629252.TASComponent
GO:0036344platelet morphogenesis23434115.24069336.IMPProcess
GO:0042803protein homodimerization activity11223950.IDAFunction
GO:0042981regulation of apoptotic process16807302.NASProcess
GO:0042995cell projection16464232.IDAComponent
GO:0044325ion channel binding17944866.19943616.IPIFunction
GO:0048041focal adhesion assembly16807302.IMPProcess
GO:0051015actin filament binding11223950.IDAFunction
GO:0051017actin filament bundle assembly-IEAProcess
GO:0051271negative regulation of cellular component movement7983147.IMPProcess
GO:0051639actin filament network formation24069336.IMPProcess
GO:0051764actin crosslink formation-IEAProcess
GO:0070062extracellular exosome19056867.19199708.21362503.23533145.HDAComponent
GO:0070527platelet aggregation23434115.IMPProcess
GO:0098978glutamatergic synapse29429936.EXPComponent
GO:0098978glutamatergic synapse29429936.IDAComponent
GO:0098978glutamatergic synapse29429936.IMPComponent
GO:0099173postsynapse organization-IEAProcess
GO:0099186structural constituent of postsynapse29429936.EXPFunction
GO:0099186structural constituent of postsynapse29429936.IDAFunction
GO:0099186structural constituent of postsynapse29429936.IMPFunction
GO:1903508positive regulation of nucleic acid-templated transcription-IEAProcess
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