EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30320371HLTF suppresses the migration and invasion of colorectal cancer cells via TGFβ/SMAD signaling in vitro.Int J Oncol2018 DecLiu Ldoi: 10.3892/ijo.2018.4591
19948885Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA.Mol Cell Biol2010 FebBlasty??k Adoi: 10.1128/MCB.00863-09
18034322The helicase-like transcription factor and its implication in cancer progression.Cell Mol Life Sci2008 FebDebauve G-
20535496Helicase-like transcription factor confers radiation resistance in cervical cancer through enhancing the DNA damage repair capacity.J Cancer Res Clin Oncol2011 AprCho Sdoi: 10.1007/s00432-010-0925-5
11904375HLTF gene silencing in human colon cancer.Proc Natl Acad Sci U S A2002 Apr 2Moinova HR-
12766908Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer.Mol Carcinog2003 JunLeung WK-
20388495CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions.Biochem Biophys Res Commun2010 May 14Kim JMdoi: 10.1016/j.bbrc.2010.04.052

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr3149046086Missense_MutationnovelI689T0.71
ACCchr3149046159Missense_MutationnovelI665F0.69
BLCAchr3149059753Missense_MutationnovelS447F0.22
BLCAchr3149040117Missense_MutationnovelE806K0.22
BLCAchr3149041492Missense_MutationnovelQ792K0.5
BLCAchr3149055333Missense_MutationNAI481M0.13
BLCAchr31490321403'UTRnovel0.26
BRCAchr3149032250Missense_MutationNAI1000M0.29
BRCAchr3149076017In_Frame_DelNAQ86del0.33
BRCAchr3149068278Missense_MutationNAL318V0.09
BRCAchr3149071250Splice_SitenovelX298_splice0.11
BRCAchr3149055398Missense_MutationnovelA460S0.32
BRCAchr3149032271Silentrs548576604D993D0.14
BRCAchr3149064844Missense_Mutationrs746982688S338C0.15
BRCAchr3149046122Missense_Mutationrs146224624I677T0.45
BRCAchr31490863495'UTRnovel0.12
CESCchr31490312953'UTRnovel0.14
CESCchr31490312963'UTRnovel0.15
CESCchr31490314143'UTRnovel0.47
CESCchr31490315263'UTRnovel0.21
CESCchr3149032241Missense_MutationnovelI1003M0.11
CESCchr3149040092Missense_MutationnovelP814L0.39
CESCchr31490312733'UTRrs5527046760.29
CESCchr3149071351SilentNAE265E0.1
CESCchr3149039167Nonsense_MutationNAS893*0.53
CESCchr3149039149Frame_Shift_DelnovelN899Tfs*90.27
CESCchr3149063440Missense_Mutationrs773811328R384H0.59
CESCchr3149055322Missense_MutationNAS485F0.24
CESCchr3149071303In_Frame_DelnovelK281del0.06
CESCchr3149060820Nonsense_MutationnovelS400*0.12
COADchr3149039068Missense_Mutationrs747207862R926Q0.31
COADchr3149041569Missense_MutationNAS766Y0.36
COADchr31490320823'UTRnovel0.48
COADchr3149071282SilentNAH288H0.29
COADchr3149075995Missense_MutationNAD94G0.15
COADchr3149041638Missense_MutationnovelK743R0.17
COADchr3149071371Nonsense_MutationnovelE259*0.09
COADchr3149041641Missense_MutationNAK742T0.39
COADchr3149060816Missense_MutationNAE401D0.32
COADchr3149039189Missense_MutationNAA886T0.14
COADchr3149048931Missense_MutationNAR563Q0.22
COADchr3149074300Frame_Shift_InsnovelM148Ifs*30.03
COADchr3149048062Missense_MutationnovelR620C0.15
COADchr3149071346Missense_Mutationrs527812739R267Q0.21
ESCAchr3149041654Missense_MutationnovelE738Q0.17
ESCAchr3149068302Frame_Shift_DelnovelT310Pfs*190.06
GBMchr3149048915Missense_MutationnovelQ568H0.1
GBMchr3149086328Nonsense_MutationNAW3*0.16
GBMchr3149050318Missense_MutationNAG511S0.29
GBMchr3149071316Missense_MutationnovelN277T0.2
GBMchr3149084824Nonsense_MutationNAS29*0.32
HNSCchr3149073267SilentnovelY195Y0.77
HNSCchr3149060782Missense_MutationnovelK413Q0.35
HNSCchr3149074231Missense_MutationnovelL171F0.18
HNSCchr3149068269Missense_MutationnovelE321K0.34
HNSCchr3149050312Missense_MutationnovelD513H0.05
HNSCchr3149039224Missense_MutationnovelS874C0.14
HNSCchr3149063484Missense_MutationnovelI369M0.3
LGGchr3149039119Missense_MutationnovelL909R0.22
LGGchr3149074309SilentNAP145P0.6
LGGchr3149032289SilentnovelT987T0.31
LGGchr3149039128Missense_MutationnovelT906I0.29
LGGchr3149040069Nonsense_MutationnovelE822*0.22
LGGchr3149041534Missense_Mutationrs761727214V778I0.46
LGGchr3149063522Missense_Mutationrs535340588A357T0.31
LGGchr3149071648Nonsense_MutationnovelE213*0.59
LGGchr3149060786Frame_Shift_InsnovelK411Nfs*30.14
LGGchr3149060787Frame_Shift_InsnovelK411Rfs*140.14
LUADchr3149048979Missense_MutationNAH547L0.16
LUADchr3149041523Missense_MutationnovelK781N0.14
LUADchr3149073302Missense_MutationnovelS184C0.06
LUADchr3149032323Missense_MutationnovelK976R0.13
LUADchr3149050254Missense_MutationnovelN532S0.17
LUADchr3149042275SilentnovelG696G0.23
LUADchr3149046258Missense_Mutationrs371233960R632C0.36
LUADchr3149041597Missense_MutationnovelD757H0.18
LUADchr3149032290Missense_Mutationrs144381721T987I0.17
LUADchr3149084865Missense_MutationnovelQ15H0.29
LUADchr3149084721Missense_MutationnovelL63F0.11
LUADchr3149071420SilentNAP242P0.41
LUADchr3149040035Missense_MutationnovelS833L0.11
LUSCchr3149068251SilentnovelL327L0.22
LUSCchr3149084849Missense_MutationnovelV21F0.18
LUSCchr3149071277Missense_MutationnovelG290V0.17
LUSCchr3149068336Splice_SitenovelX299_splice0.37
LUSCchr3149071385Missense_MutationnovelR254P0.28
LUSCchr3149071397Nonsense_MutationNAW250*0.37
LUSCchr3149050365Missense_MutationnovelG495V0.53
LUSCchr3149068278Missense_MutationNAL318V0.07
LUSCchr31490321143'UTRnovel0.35
LUSCchr3149040081Missense_MutationNAA818T0.19
LUSCchr3149059793Missense_MutationNAV434F0.36
LUSCchr3149074349Splice_SitenovelX132_splice0.21
LUSCchr3149060792Silentrs137985485P409P0.27
LUSCchr3149071277Missense_Mutationrs768864078G290E0.25
LUSCchr3149075910Silentrs753530650I122I0.07
LUSCchr3149050284Missense_MutationnovelS522L0.09
LUSCchr3149042190Missense_MutationNAA725S0.25
OVchr3149084839Missense_MutationNAN24S0.46
OVchr3149039653Frame_Shift_InsnovelK848Tfs*250.08
OVchr3149041572Missense_MutationnovelD765G0.04
PRADchr3149075971Missense_MutationnovelN102S0.07
PRADchr3149042218SilentNAI715I0.27
PRADchr3149048155Missense_MutationnovelI589V0.46
PRADchr3149059765Missense_MutationnovelA443G0.35
READchr3149071395Missense_MutationnovelM251L0.04
READchr3149060829Missense_MutationNAS397N0.19
READchr3149074281Nonsense_MutationNAE155*0.38
READchr3149039681Missense_MutationnovelM839L0.37
READchr3149050354Missense_MutationnovelK499Q0.35
READchr3149071648Missense_MutationNAE213K0.33
READchr3149039181Missense_MutationNAK888N0.23
SARCchr3149074323Missense_MutationnovelA141T0.29
SKCMchr3149063458Missense_MutationnovelS378L0.29
SKCMchr3149074341Missense_MutationNAP135S0.26
SKCMchr3149046221Missense_MutationnovelR644K0.31
SKCMchr3149039194Missense_MutationNAS884F0.44
SKCMchr3149084806Missense_MutationnovelP35L0.28
SKCMchr3149042171Missense_MutationNAP731L0.16
SKCMchr3149074262Missense_MutationNAS161L0.26
SKCMchr3149075949SilentNAG109G0.45
SKCMchr3149074274Missense_MutationNAR157K0.47
SKCMchr3149041640SilentNAK742K0.37
SKCMchr3149039193SilentNAS884S0.24
STADchr3149071434Missense_MutationNAT238P0.4
STADchr3149068239Splice_SitenovelX330_splice0.08
STADchr3149071347Nonsense_Mutationrs770061848R267*0.34
STADchr3149046092Missense_MutationnovelA687G0.41
STADchr3149046170Missense_MutationNAR661H0.38
STADchr3149071601Frame_Shift_InsnovelH228Qfs*20.18
STADchr3149084738Missense_MutationNAV58I0.27
STADchr3149063440Missense_Mutationrs773811328R384H0.16
UCECchr3149071601SilentNAH228H0.3
UCECchr3149040108Missense_MutationnovelL809V0.05
UCECchr3149041499SilentNAQ789Q0.37
UCECchr3149048931Missense_MutationNAR563Q0.34
UCECchr3149084798Nonsense_MutationNAE38*0.32
UCECchr3149039068Missense_Mutationrs747207862R926Q0.22
UCECchr3149040126Missense_MutationNAD803Y0.28
UCECchr3149075990Missense_MutationNAN96H0.31
UCECchr3149084720SilentNAR64R0.31
UCECchr3149032365Missense_MutationnovelV962A0.23
UCECchr3149048880Missense_MutationnovelR580I0.36
UCECchr3149068255Missense_MutationNAK325N0.39
UCECchr3149064795SilentnovelS354S0.15
UCECchr3149074270SilentnovelK158K0.57
UCECchr3149032254Missense_MutationnovelK999T0.29
UCECchr3149046206Missense_MutationNAK649T0.32
UCECchr3149060650Missense_MutationNAR426S0.11
UCECchr3149071356Missense_Mutationrs140551459W264R0.44
UCECchr3149084688SilentnovelT74T0.48
UCECchr31490321553'UTRnovel0.22
UCECchr3149050344Missense_MutationnovelV502A0.22
UCECchr3149071346Missense_Mutationrs527812739R267Q0.23
UCECchr31490313953'UTRnovel0.43
UCECchr3149034991Missense_MutationNAN935T0.32
UCECchr3149063523Splice_Regionrs547442134D356D0.16
UCECchr31490313953'UTRnovel0.6
UCECchr3149039690Missense_MutationnovelN836D0.37
UCECchr3149041644Missense_MutationnovelR741I0.26
UCECchr3149071371Nonsense_MutationnovelE259*0.18
UCECchr3149050308Missense_MutationnovelR514H0.21
UCECchr3149084744Missense_MutationnovelD56N0.29
UCECchr31490313793'UTRrs1928043500.38
UCECchr3149075888Missense_MutationnovelI130L0.34
UCECchr3149059719Missense_MutationnovelK458N0.52
UCECchr3149071341Missense_Mutationrs80336605D269N0.38
UCECchr3149084761Missense_MutationnovelT50S0.27
UCECchr3149084882Missense_MutationNAV10I0.12
UCECchr3149071648Nonsense_MutationnovelE213*0.44
UCECchr3149086319Missense_MutationnovelK6N0.39
UCECchr3149032224Missense_MutationnovelL1009S0.14
UCECchr31490864405'UTRnovel0.38
UCECchr3149041506Missense_MutationnovelV787A0.33
UCECchr3149048086Nonsense_MutationnovelE612*0.48
UCECchr3149060792Silentrs137985485P409P0.4
UCECchr3149040078Missense_Mutationrs372238111R819C0.29
UCECchr3149068291SilentNAH313H0.11
UCECchr3149032310Frame_Shift_DelnovelL980Rfs*80.25
UCECchr31490321593'UTRnovel0.49
UCECchr3149071641Missense_MutationnovelD215G0.35
UCECchr31490313953'UTRnovel0.33
UCECchr3149046138Missense_MutationnovelD672Y0.54
UCECchr3149040038Missense_Mutationrs554839264S832N0.13
UCECchr31490321723'UTRnovel0.1
UCECchr3149046206Missense_MutationNAK649T0.2
UCECchr3149075991SilentnovelK95K0.08
UCECchr31490313953'UTRnovel0.34
UCECchr3149039686Missense_MutationNAA837V0.38
UCECchr3149048925Missense_MutationnovelP565L0.05
UCECchr3149039622SilentnovelS858S0.39
UCECchr3149075953Missense_Mutationrs781449206V108A0.35
UCECchr3149032230Missense_MutationnovelI1007T0.5
UCECchr3149071430Missense_MutationnovelP239Q0.33
UCECchr31490320543'UTRnovel0.46
UCECchr3149064840Missense_MutationNAM339I0.24
UCECchr3149040065Missense_MutationNAK823T0.2
UCECchr3149071413Missense_MutationnovelK245Q0.05
UCECchr3149075991Missense_MutationNAK95N0.34
UCECchr3149039602Missense_MutationnovelS865F0.14
UCECchr3149041587Missense_MutationnovelC760Y0.18
UCECchr3149071316Missense_MutationNAN277I0.38
UCECchr3149039679Missense_MutationNAM839I0.4
UCECchr3149063522Missense_Mutationrs535340588A357T0.27
UCECchr3149063440Missense_Mutationrs773811328R384H0.26
UCECchr3149068311Missense_MutationnovelV307L0.45
UCECchr3149073240Missense_MutationnovelQ204H0.34
UCSchr3149039181Missense_MutationNAK888N0.31
UCSchr3149050333Missense_MutationnovelF506V0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCDEL0.11550.11092
KIRPAMP0.31250.15981
PAADAMP0.09780.16151

Survival Analysis
CancerP-value Q-value
SARC0.0001

Kaplan-Meier Survival Analysis

SKCM0.0047

Kaplan-Meier Survival Analysis

PRAD0.0084

Kaplan-Meier Survival Analysis

BRCA0.028

Kaplan-Meier Survival Analysis

PCPG0.014

Kaplan-Meier Survival Analysis

BLCA0.04

Kaplan-Meier Survival Analysis

CESC0.029

Kaplan-Meier Survival Analysis

KICH0.0015

Kaplan-Meier Survival Analysis

UCEC0.002

Kaplan-Meier Survival Analysis

LIHC0.0024

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • PRI
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000071794 (Gene tree)
Gene ID
6596
Gene Symbol
HLTF
Alias
HIP116A|HLTF1|RNF80|SNF2L3|SMARCA3
Full Name
helicase like transcription factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
56,438 bases
Position
chr3:149,030,117-149,086,554
Accession
11099
RBP type
non-canonical RBP
Summary
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000493881HLTF-207461--- (aa)--
ENST00000465259HLTF-2035306XM_011513093ENSP000004207451008 (aa)XP_011511395A0A0C4DGA6
ENST00000310053HLTF-2015317XM_011513091ENSP000003089441009 (aa)XP_011511393Q14527
ENST00000494055HLTF-2083633-ENSP000004204291009 (aa)-Q14527
ENST00000497427HLTF-209570--- (aa)--
ENST00000472830HLTF-205533--- (aa)--
ENST00000467858HLTF-2041276-ENSP00000420106425 (aa)-H7C5K0
ENST00000392912HLTF-2023896-ENSP000003766441009 (aa)-Q14527
ENST00000481663HLTF-206501--- (aa)--
Gene Model
Click here to download ENSG00000071794's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000071794Platelet Function Tests2.0488300E-005-
ENSG00000071794Polychlorinated Biphenyls2E-725839716
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000071794rs67643523149039038?Polychlorinated biphenyl levels25839716[0.52-1.1] unit increase0.81EFO_0007042
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000071794's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEAFunction
GO:0001228DNA-binding transcription activator activity, RNA polymerase II-specific-IEAFunction
GO:0003677DNA binding7876228.TASFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0004386helicase activity-IEAFunction
GO:0005515protein binding10391891.18316726.18719106.23415230.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm-IEAComponent
GO:0006325chromatin organization-IEAProcess
GO:0006355regulation of transcription, DNA-templated7876228.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016567protein ubiquitination-IEAProcess
GO:0016567protein ubiquitination-TASProcess
GO:0016887ATPase activity-IEAFunction
GO:0031625ubiquitin protein ligase binding25023518.IDAFunction
GO:0045944positive regulation of transcription by RNA polymerase II-IEAProcess
GO:0061630ubiquitin protein ligase activity18316726.18719106.19723507.21396873.26350214.EXPFunction
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