EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19690174Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.J Biol Chem2009 Oct 9Bouzakri Kdoi: 10.1074/jbc.M109.048058
18981001Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma.Clin Cancer Res2008 Nov 1Liang JJdoi: 10.1158/1078-0432.CCR-08-0381.
12612079The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.Mol Cell Biol2003 MarWright JH-
24233838SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells.Carcinogenesis2014 MarChen Sdoi: 10.1093/carcin/bgt371
29620289Function of microRNA141 in human breast cancer through cytotoxic CD4+ T cells regulated by MAP4K4 expression.Mol Med Rep2018 JunZhang Qdoi: 10.3892/mmr.2018.8814
26549737Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells.Mol Med Rep2016 JanLiu YFdoi: 10.3892/mmr.2015.4510
29138007RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.Biochim Biophys Acta Mol Cell Res2018 FebLin JCdoi: 10.1016/j.bbamcr.2017.11.005

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2101866564Missense_Mutationrs369479508R703C0.74
ACCchr21018916123'Flanknovel0.33
BLCAchr2101839879SilentnovelP278P0.29
BLCAchr2101844178Missense_MutationNAS367F0.13
BLCAchr2101877113Missense_MutationNAL973F0.37
BLCAchr2101863821Intronnovel0.19
BLCAchr2101823940Nonsense_MutationnovelE65*0.37
BLCAchr2101887193Missense_MutationnovelD1098N0.44
BLCAchr2101887835Missense_MutationnovelE1132Q0.37
BLCAchr2101882625Missense_MutationnovelE1009K0.05
BLCAchr2101877122Missense_MutationnovelL976V0.15
BRCAchr2101866473Silentrs759387518V672V0.59
BRCAchr2101859664Missense_MutationnovelE502K0.1
BRCAchr21018917973'Flanknovel0.21
BRCAchr2101860789Intronnovel0.11
BRCAchr2101831804Missense_MutationNAE198K0.24
BRCAchr2101834442Missense_MutationNAE225Q0.06
BRCAchr2101859777Silentrs746007591P539P0.23
BRCAchr2101887865Missense_MutationNAV1142F0.2
BRCAchr2101870310Missense_MutationnovelL804F0.09
BRCAchr2101834412Missense_MutationNAD215N0.1
BRCAchr2101825387Silentrs773806505L125L0.43
BRCAchr2101839858SilentNAV271V0.32
BRCAchr2101839978SilentNAK311K0.29
BRCAchr21018917193'Flanknovel0.41
BRCAchr2101874085Missense_MutationNAG880A0.37
BRCAchr2101888912Missense_MutationNAF1205L0.22
BRCAchr21018916183'Flankrs3688651360.16
BRCAchr2101855989Missense_MutationNAE416Q0.24
BRCAchr21018912723'UTRnovel0.18
BRCAchr2101797256Intronnovel0.05
BRCAchr2101829537Missense_MutationNAH151Y0.24
CESCchr21016980585'Flankrs7807743090.18
CESCchr21018923193'Flanknovel0.51
CESCchr2101885222Missense_MutationNAL1041V0.3
CESCchr2101839825SilentnovelK260K0.25
CESCchr2101831850Missense_MutationnovelR213T0.34
CESCchr21018912693'UTRnovel0.13
CESCchr21018912713'UTRnovel0.14
CESCchr2101859823Missense_Mutationrs760266370E555K0.16
CESCchr2101867271Missense_MutationNAE728K0.14
CESCchr2101823969SilentnovelK74K0.35
CESCchr2101859946Intronnovel0.36
CESCchr2101887226Missense_MutationnovelL1109V0.38
CHOLchr21018917203'Flanknovel0.31
CHOLchr2101864004IntronNA0.4
COADchr21018914003'Flanknovel0.26
COADchr2101860809Intronnovel0.21
COADchr2101866558Missense_Mutationrs776570846G701R0.22
COADchr2101885251Missense_MutationNAW1050C0.34
COADchr2101831813Missense_MutationnovelA201T0.27
COADchr2101877116Missense_MutationnovelE974K0.27
COADchr2101859059Missense_MutationnovelL487I0.05
COADchr2101859883Intronnovel0.39
COADchr2101874201Missense_Mutationrs375228116R919C0.35
COADchr2101864037IntronNA0.38
COADchr2101877066Missense_MutationnovelK957T0.27
COADchr2101831739Missense_MutationnovelA176D0.26
COADchr2101867251Frame_Shift_DelNAN722Mfs*30.46
COADchr2101869631Missense_Mutationrs199996114A744T0.27
COADchr2101863873Intronrs7527688920.32
COADchr2101831743Missense_MutationNAQ177H0.24
COADchr2101859774SilentNAQ538Q0.3
COADchr2101869686Missense_Mutationrs770671445T762M0.38
COADchr2101870324Missense_Mutationrs372783884T809M0.25
COADchr2101859030Missense_MutationNAR477Q0.13
COADchr2101888824SilentNAG1175G0.55
COADchr21018913883'Flanknovel0.45
COADchr2101839821Missense_MutationNAS259L0.22
COADchr21018913663'Flanknovel0.31
COADchr2101859674Missense_MutationnovelR505L0.13
COADchr2101885233SilentNAS1044S0.21
COADchr2101888914Missense_MutationNAF1205L0.07
COADchr2101887864SilentNAG1141G0.36
COADchr2101891184Missense_MutationNAR1219W0.33
COADchr2101856025Nonsense_MutationNAR428*0.17
COADchr2101698101Frame_Shift_DelnovelS9Vfs*620.09
COADchr2101831764SilentNAR184R0.19
COADchr2101887837Silentrs753534395E1132E0.2
COADchr2101891184Missense_MutationNAR1219W0.27
COADchr2101866433Missense_MutationNAI659S0.23
COADchr2101874201Missense_Mutationrs375228116R919C0.24
COADchr2101888826Frame_Shift_DelNAG1177Efs*50.19
COADchr21018913293'Flanknovel0.16
COADchr2101866557Silentrs376560483S700S0.47
COADchr2101859699SilentNAQ513Q0.16
ESCAchr2101839961Missense_MutationnovelI306V0.38
ESCAchr21018945963'Flanknovel0.44
ESCAchr2101861030Intronnovel0.15
ESCAchr2101887257Intronnovel0.18
ESCAchr2101844189Missense_MutationnovelR371W0.3
GBMchr2101823974Missense_MutationNAY76F0.33
GBMchr2101866564Missense_Mutationrs369479508R703C0.29
GBMchr2101831831Missense_MutationnovelD207Y0.29
GBMchr2101839928Nonsense_MutationnovelE295*0.23
GBMchr2101877051Missense_MutationnovelR952I0.34
GBMchr2101869756SilentNAG785G0.73
HNSCchr2101835939Missense_MutationnovelI245S0.23
HNSCchr2101888924Missense_MutationnovelR1209C0.32
HNSCchr2101829507Missense_MutationnovelL141V0.33
HNSCchr2101859858SilentnovelA566A0.29
HNSCchr2101839987SilentNAG314G0.21
HNSCchr2101866557Silentrs376560483S700S0.31
KIRCchr2101887824Missense_MutationnovelT1128R0.17
KIRCchr2101885202Missense_MutationNAI1034N0.19
KIRCchr2101844139Missense_MutationNAR354Q0.35
KIRCchr2101839903Nonsense_MutationnovelH286_P287insK*E0.03
KIRCchr2101870382SilentNAT828T0.11
KIRPchr2101877130Silentrs575144210V978V0.3
KIRPchr21018915703'Flanknovel0.44
KIRPchr2101877082SilentNAI962I0.6
LAMLchr2101860937Missense_MutationnovelG606V0.27
LGGchr2101887164Missense_Mutationrs778889965Y1088C0.13
LGGchr2101839954Missense_MutationnovelK303N0.35
LIHCchr2101885212SilentnovelL1037L0.24
LIHCchr2101860987Splice_SitenovelX622_splice0.28
LIHCchr2101863983IntronNA0.3
LIHCchr2101867239Missense_MutationNAS717C0.27
LUADchr21018912893'UTRrs7690586400.15
LUADchr2101869628Missense_MutationnovelT743S0.38
LUADchr2101885246Missense_MutationnovelA1049P0.4
LUADchr2101877128Missense_MutationNAV978I0.25
LUADchr2101831802Missense_MutationnovelP197H0.63
LUADchr2101797348Intronnovel0.83
LUADchr2101874145Missense_Mutationrs375209088S900L0.44
LUADchr2101825376Frame_Shift_DelnovelN123Tfs*160.22
LUADchr2101859863Missense_MutationNAE568V0.2
LUSCchr2101864968SilentNAS635S0.33
LUSCchr2101835953Missense_MutationNAP250S0.16
LUSCchr2101864022Intronnovel0.15
LUSCchr21018913613'Flanknovel0.36
LUSCchr2101882669SilentnovelC1023C0.08
LUSCchr2101844275SilentNAI399I0.19
LUSCchr2101882655Missense_MutationNAD1019N0.37
LUSCchr2101859030Missense_MutationNAR477Q0.22
LUSCchr2101839919Nonsense_MutationNAQ292*0.2
LUSCchr2101823977Missense_MutationnovelS77C0.1
LUSCchr2101863994Intronrs7630831410.28
LUSCchr2101839937Missense_MutationnovelV298L0.17
LUSCchr2101859030Missense_MutationNAR477P0.23
LUSCchr2101844137SilentNAR353R0.43
OVchr2101860648Intronnovel0.89
OVchr2101844297SilentnovelR407R0.09
OVchr2101829535Frame_Shift_InsnovelH151Mfs*190.05
OVchr2101874129Missense_MutationNAP895S0.13
PAADchr2101698535Frame_Shift_InsnovelR43Sfs*40.07
PAADchr2101844253Missense_MutationnovelL392Q0.08
PRADchr2101870370SilentnovelE824E0.18
PRADchr2101835970Frame_Shift_Delrs774203808K257Nfs*100.5
PRADchr2101888849Nonsense_MutationnovelR1184*0.16
READchr2101860814Intronnovel0.47
READchr2101823988Missense_MutationNAN81H0.09
READchr2101825403Missense_MutationNAA131T0.43
READchr2101887097Nonsense_MutationNAE1066*0.37
READchr2101829580Missense_MutationNAA165V0.36
SARCchr2101885239SilentnovelE1046E0.44
SARCchr2101859854Missense_Mutationrs781410462R565Q0.82
SARCchr2101698538Missense_MutationnovelK41N0.36
SARCchr2101877140Missense_MutationnovelI982V0.18
SKCMchr2101874226Missense_MutationNAS927F0.46
SKCMchr2101866442Missense_MutationnovelR662K0.11
SKCMchr2101874080Splice_SiteNAX879_splice0.69
SKCMchr2101866446SilentnovelL663L0.33
SKCMchr2101874201Missense_Mutationrs375228116R919C0.48
SKCMchr2101888849Nonsense_MutationnovelR1184*0.44
SKCMchr2101877028Frame_Shift_InsnovelS953Kfs*300.04
SKCMchr2101882627SilentNAE1009E0.39
SKCMchr2101839967Missense_Mutationrs779064004R308C0.07
SKCMchr2101885195Missense_MutationnovelE1032K0.27
SKCMchr2101825413Missense_MutationNAS134F0.21
SKCMchr2101873670SilentNAL847L0.21
SKCMchr2101863882IntronNA0.52
SKCMchr2101829540Missense_MutationNAR152G0.56
SKCMchr2101844146SilentnovelF356F0.48
SKCMchr2101825348SilentNAS112S0.1
SKCMchr2101885233SilentnovelS1044S0.22
SKCMchr2101873654Missense_MutationnovelS842F0.35
SKCMchr2101864033IntronNA0.14
SKCMchr2101698507Missense_MutationNAV31G0.06
SKCMchr2101860851SilentNAN577N0.69
SKCMchr2101831787Missense_MutationnovelP192L0.51
SKCMchr2101877032Missense_MutationNAG946C0.2
SKCMchr2101842630Missense_MutationNAS324I0.18
SKCMchr2101870380Missense_MutationNAT828A0.3
SKCMchr2101825355Missense_MutationNAD115N0.15
SKCMchr2101887905Missense_MutationNAV1155A0.37
SKCMchr2101888814Missense_MutationnovelQ1172L0.5
SKCMchr2101790745Nonsense_MutationNAL50*0.33
SKCMchr2101860932SilentnovelS604S0.2
STADchr2101835969Frame_Shift_InsnovelW258Mfs*70.33
STADchr2101859786Silentrs763922718P542P0.45
STADchr2101835970Frame_Shift_DelnovelK257Mfs*70.22
STADchr2101859780Silentrs762602382P540P0.23
STADchr2101859753Silentrs186857052P531P0.47
STADchr2101869719Missense_Mutationrs545368433T773M0.27
STADchr2101839967Missense_Mutationrs779064004R308C0.22
STADchr2101859072Missense_MutationnovelA491V0.41
STADchr2101844282Frame_Shift_DelnovelQ402Gfs*20.2
STADchr2101874161Missense_MutationNAN905K0.21
STADchr2101844297Nonsense_MutationNAR407*0.2
STADchr2101863855Intronrs617417560.19
STADchr2101882568Missense_MutationNAR990C0.17
STADchr2101831801Frame_Shift_DelnovelE198Vfs*380.71
STADchr2101835969Frame_Shift_InsnovelW258Mfs*70.32
STADchr2101869669SilentNAR756R0.29
STADchr2101887797Missense_MutationnovelP1119H0.2
STADchr2101869706Missense_MutationNAE769K0.56
STADchr2101698504Missense_MutationNAV30A0.19
THCAchr2101882597SilentnovelN999N0.13
THCAchr2101865032Missense_MutationnovelT657P0.2
THCAchr2101834442Missense_MutationNAE225Q0.13
UCECchr2101871559Intronnovel0.35
UCECchr21018913883'Flanknovel0.24
UCECchr21018944093'Flanknovel0.39
UCECchr2101859916Intronnovel0.39
UCECchr21018913863'Flanknovel0.36
UCECchr2101856119Missense_MutationnovelR459M0.22
UCECchr21018945763'Flanknovel0.35
UCECchr21018921983'Flanknovel0.3
UCECchr2101869713Missense_MutationnovelS771L0.45
UCECchr2101855993Missense_MutationnovelR417L0.41
UCECchr2101860885Missense_MutationnovelG589C0.06
UCECchr2101885274Missense_MutationNAF1058C0.4
UCECchr2101844115Missense_MutationnovelV346A0.33
UCECchr2101863922Intronnovel0.4
UCECchr2101864036Intronrs7546749260.36
UCECchr2101874234Silentrs577039991L930L0.37
UCECchr2101698515Missense_MutationnovelG34C0.07
UCECchr2101860975Missense_MutationnovelA619T0.34
UCECchr2101869735Silentrs760805317D778D0.31
UCECchr2101888914Missense_MutationNAF1205L0.32
UCECchr2101885274Missense_MutationNAF1058C0.06
UCECchr2101887802Missense_Mutationrs575872758A1121T0.23
UCECchr21018916533'Flanknovel0.11
UCECchr2101855988SilentNAR415R0.41
UCECchr21018921983'Flanknovel0.51
UCECchr2101888818SilentnovelT1173T0.32
UCECchr21018913863'Flanknovel0.39
UCECchr2101839988Missense_MutationNAE315K0.59
UCECchr2101865037Splice_SiteNAX658_splice0.37
UCECchr2101869767Frame_Shift_DelnovelT790Pfs*130.16
UCECchr2101860667Intronnovel0.4
UCECchr21018926913'Flanknovel0.23
UCECchr2101844270Missense_MutationnovelR398W0.47
UCECchr21018945473'Flanknovel0.16
UCECchr2101861073Intronnovel0.27
UCECchr21018916283'Flanknovel0.23
UCECchr2101839987SilentNAG314G0.38
UCECchr2101859672SilentnovelH504H0.37
UCECchr2101863934Intronnovel0.29
UCECchr21018927513'Flanknovel0.54
UCECchr21018942303'Flanknovel0.41
UCECchr2101859859Nonsense_MutationnovelR567*0.41
UCECchr2101860745Intronnovel0.26
UCECchr21018924393'Flanknovel0.17
UCECchr2101871531Intronnovel0.32
UCECchr21018920403'Flanknovel0.47
UCECchr2101859797Missense_MutationNAR546M0.29
UCECchr2101887162SilentnovelI1087I0.45
UCECchr2101870324Missense_Mutationrs372783884T809M0.3
UCECchr2101882647Missense_MutationnovelT1016S0.37
UCECchr2101825333SilentnovelF107F0.41
UCECchr2101874097Missense_MutationnovelD884A0.38
UCECchr2101698126Missense_MutationnovelS16P0.42
UCECchr2101869730Missense_MutationnovelE777K0.35
UCECchr21018921983'Flanknovel0.6
UCECchr2101844300Frame_Shift_InsNAE411Gfs*20.37
UCECchr2101869738Silentrs551450744D779D0.23
UCECchr21018925293'Flanknovel0.1
UCECchr21018945963'Flanknovel0.36
UCECchr2101790723Nonsense_MutationnovelR43*0.22
UCECchr2101844270Missense_MutationnovelR398W0.38
UCECchr21018944643'Flanknovel0.17
UCECchr2101888924Missense_MutationnovelR1209C0.33
UCECchr2101790724Missense_MutationNAR43Q0.33
UCECchr2101870406SilentNAI836I0.57
UCECchr21018945963'Flanknovel0.28
UCECchr2101797296Intronnovel0.37
UCECchr2101824010Missense_MutationNAA88V0.12
UCECchr2101835909Missense_MutationnovelD235G0.42
UCECchr2101870401Missense_MutationnovelL835I0.67
UCECchr2101888931Missense_MutationnovelD1211G0.35
UCECchr2101829504Nonsense_MutationNAG140*0.04
UCECchr2101839822Silentrs369276793S259S0.38
UCECchr2101835970Frame_Shift_Delrs774203808K257Nfs*100.42
UCECchr21018922033'Flanknovel0.13
UCECchr2101874135Missense_Mutationrs781009612R897W0.03
UCECchr2101859744SilentnovelH528H0.08
UCECchr2101835959Missense_MutationNAR252W0.1
UCECchr2101844297Nonsense_MutationNAR407*0.13
UCECchr2101871556Intronnovel0.09
UCECchr21018944773'Flanknovel0.34
UCECchr21018943833'Flanknovel0.3
UCECchr2101856101Missense_MutationNAR453Q0.18
UCECchr21018924003'Flanknovel0.27
UCECchr21018944653'Flanknovel0.38
UCECchr21018921983'Flanknovel0.33
UCECchr2101839866Missense_MutationNAY274C0.07
UCECchr2101797251Intronnovel0.19
UCECchr2101869630Silentrs750583925T743T0.26
UCECchr21018945963'Flanknovel0.45
UCECchr2101860926SilentnovelS602S0.11
UCECchr2101835917Missense_MutationnovelP238S0.14
UCECchr2101859741SilentnovelD527D0.5
UCECchr2101882567SilentnovelL989L0.21
UCECchr21018913283'Flanknovel0.19
UCECchr2101864012IntronNA0.35
UCECchr2101866469Missense_MutationNAL671P0.16
UCECchr2101867245Missense_Mutationrs768378384R719H0.1
UCECchr2101825333SilentnovelF107F0.38
UCECchr2101863949Intronnovel0.47
UCECchr2101874203SilentnovelR919R0.42
UCECchr21018916173'Flanknovel0.33
UCECchr21018917473'Flanknovel0.38
UCECchr2101825391Nonsense_MutationnovelE127*0.3
UCECchr2101831781Missense_MutationnovelG190D0.4
UCECchr2101867257Missense_MutationnovelA723V0.4
UCECchr2101871512Intronnovel0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.16670.15279
PAADDEL0.03260.2014

Survival Analysis
CancerP-value Q-value
THYM0.0044

Kaplan-Meier Survival Analysis

STAD0.0042

Kaplan-Meier Survival Analysis

SARC0.00032

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00089

Kaplan-Meier Survival Analysis

HNSC0.0073

Kaplan-Meier Survival Analysis

KIRP0.0015

Kaplan-Meier Survival Analysis

PAAD0.0019

Kaplan-Meier Survival Analysis

BLCA0.0087

Kaplan-Meier Survival Analysis

CESC0.012

Kaplan-Meier Survival Analysis

LAML0.0024

Kaplan-Meier Survival Analysis

LIHC0.027

Kaplan-Meier Survival Analysis

LGG0.024

Kaplan-Meier Survival Analysis

LUAD0.0049

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000071054 (Gene tree)
Gene ID
9448
Gene Symbol
MAP4K4
Alias
HGK|NIK|FLH21957
Full Name
mitogen-activated protein kinase kinase kinase kinase 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
197,841 bases
Position
chr2:101,696,850-101,894,690
Accession
6866
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30200638RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.Int J Mol Sci2018 Sep 6Peng HYdoi: 10.3390/ijms19092646.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000496989MAP4K4-217574--- (aa)--
ENST00000476609MAP4K4-2133598--- (aa)--
ENST00000302217MAP4K4-2016624-ENSP00000303600987 (aa)-C9J840
ENST00000347699MAP4K4-2033792XM_005264069ENSP000003143631239 (aa)XP_005264126O95819
ENST00000498066MAP4K4-2181017--- (aa)--
ENST00000491743MAP4K4-216646--- (aa)--
ENST00000477711MAP4K4-214606--- (aa)--
ENST00000627726MAP4K4-2203135-ENSP000004871761044 (aa)-A0A0D9SG62
ENST00000634702MAP4K4-2213800XM_005264050ENSP000004895791165 (aa)XP_005264107O95819
ENST00000413150MAP4K4-2066958XM_005264071ENSP000003897521154 (aa)XP_005264128E7ENQ1
ENST00000324219MAP4K4-2027526XM_017005350ENSP000003136441235 (aa)XP_016860839G5E948
ENST00000427603MAP4K4-211526-ENSP00000403016102 (aa)-E7ETN6
ENST00000417294MAP4K4-2074251-ENSP000004097201170 (aa)-H7C360
ENST00000625522MAP4K4-2197458XM_005264048ENSP000004861161320 (aa)XP_005264105A0A0D9SEY1
ENST00000421882MAP4K4-2093416-ENSP000003960661056 (aa)-H7C0P6
ENST00000425019MAP4K4-2104403XM_005264060ENSP000003928301272 (aa)XP_005264117E7EN19
ENST00000350198MAP4K4-2047316XM_017005373ENSP000002811111165 (aa)XP_016860862G3XAA2
ENST00000350878MAP4K4-2057640XM_005264057ENSP000003436581273 (aa)XP_005264114O95819
ENST00000489490MAP4K4-215362--- (aa)--
ENST00000456652MAP4K4-2123855-ENSP000003873701038 (aa)-E7EX83
ENST00000418101MAP4K4-208776-ENSP00000414766258 (aa)-H7C3Z6
Gene Model
Click here to download ENSG00000071054's gene model file
Pathways
Pathway IDPathway NameSource
hsa04010MAPK signaling pathwayKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000071054rs340431592101796654CParkinson's disease28892059[1.06-1.10]1.08EFO_0002508
ENSG00000071054rs776570342101857264GAlzheimer's disease30636644[3.02-10.81]6.912992EFO_0000249
ENSG00000071054rs65430872101699471?White blood cell count30595370EFO_0004308
ENSG00000071054rs1155677232101746707?Eosinophil counts30595370EFO_0004842
ENSG00000071054rs1119552022101788512?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000071054's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000071054MAP4K4100100.000ENSMUSG00000026074Map4k4100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000165MAPK cascade21873635.IBAProcess
GO:0001953negative regulation of cell-matrix adhesion25490267.NASProcess
GO:0004111creatine kinase activity23207904.IDAFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity9890973.IDAFunction
GO:0005515protein binding12387898.14966141.IPIFunction
GO:0005524ATP binding9890973.IDAFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm14966141.IDAComponent
GO:0005925focal adhesion25490267.IDAComponent
GO:0006468protein phosphorylation9890973.IDAProcess
GO:0008017microtubule binding25490267.IDAFunction
GO:0023014signal transduction by protein phosphorylation21873635.IBAProcess
GO:0030033microvillus assembly22797597.IMPProcess
GO:0030335positive regulation of cell migration24163766.IMPProcess
GO:0031098stress-activated protein kinase signaling cascade21873635.IBAProcess
GO:0032014positive regulation of ARF protein signal transduction25490267.ISSProcess
GO:0032147activation of protein kinase activity21873635.IBAProcess
GO:0035556intracellular signal transduction9890973.IDAProcess
GO:0043066negative regulation of apoptotic process21196414.IMPProcess
GO:0043547positive regulation of GTPase activity25490267.ISSProcess
GO:0046328regulation of JNK cascade14966141.IDAProcess
GO:0048812neuron projection morphogenesis21873635.IBAProcess
GO:0051549positive regulation of keratinocyte migration25490267.ISSProcess
GO:0051894positive regulation of focal adhesion assembly25490267.ISSProcess
GO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulus-IEAProcess
GO:0070571negative regulation of neuron projection regeneration-IEAProcess
GO:1903393positive regulation of adherens junction organization25490267.ISSProcess
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