EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19690174	Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.	J Biol Chem	2009 Oct 9	Bouzakri K	doi: 10.1074/jbc.M109.048058
18981001	Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma.	Clin Cancer Res	2008 Nov 1	Liang JJ	doi: 10.1158/1078-0432.CCR-08-0381.
12612079	The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.	Mol Cell Biol	2003 Mar	Wright JH	-
24233838	SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells.	Carcinogenesis	2014 Mar	Chen S	doi: 10.1093/carcin/bgt371
29620289	Function of microRNA141 in human breast cancer through cytotoxic CD4+ T cells regulated by MAP4K4 expression.	Mol Med Rep	2018 Jun	Zhang Q	doi: 10.3892/mmr.2018.8814
26549737	Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells.	Mol Med Rep	2016 Jan	Liu YF	doi: 10.3892/mmr.2015.4510
29138007	RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.	Biochim Biophys Acta Mol Cell Res	2018 Feb	Lin JC	doi: 10.1016/j.bbamcr.2017.11.005

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	101866564	Missense_Mutation	rs369479508	R703C	0.74
ACC	chr2	101891612	3'Flank	novel		0.33
BLCA	chr2	101839879	Silent	novel	P278P	0.29
BLCA	chr2	101844178	Missense_Mutation	NA	S367F	0.13
BLCA	chr2	101877113	Missense_Mutation	NA	L973F	0.37
BLCA	chr2	101863821	Intron	novel		0.19
BLCA	chr2	101823940	Nonsense_Mutation	novel	E65*	0.37
BLCA	chr2	101887193	Missense_Mutation	novel	D1098N	0.44
BLCA	chr2	101887835	Missense_Mutation	novel	E1132Q	0.37
BLCA	chr2	101882625	Missense_Mutation	novel	E1009K	0.05
BLCA	chr2	101877122	Missense_Mutation	novel	L976V	0.15
BRCA	chr2	101866473	Silent	rs759387518	V672V	0.59
BRCA	chr2	101859664	Missense_Mutation	novel	E502K	0.1
BRCA	chr2	101891797	3'Flank	novel		0.21
BRCA	chr2	101860789	Intron	novel		0.11
BRCA	chr2	101831804	Missense_Mutation	NA	E198K	0.24
BRCA	chr2	101834442	Missense_Mutation	NA	E225Q	0.06
BRCA	chr2	101859777	Silent	rs746007591	P539P	0.23
BRCA	chr2	101887865	Missense_Mutation	NA	V1142F	0.2
BRCA	chr2	101870310	Missense_Mutation	novel	L804F	0.09
BRCA	chr2	101834412	Missense_Mutation	NA	D215N	0.1
BRCA	chr2	101825387	Silent	rs773806505	L125L	0.43
BRCA	chr2	101839858	Silent	NA	V271V	0.32
BRCA	chr2	101839978	Silent	NA	K311K	0.29
BRCA	chr2	101891719	3'Flank	novel		0.41
BRCA	chr2	101874085	Missense_Mutation	NA	G880A	0.37
BRCA	chr2	101888912	Missense_Mutation	NA	F1205L	0.22
BRCA	chr2	101891618	3'Flank	rs368865136		0.16
BRCA	chr2	101855989	Missense_Mutation	NA	E416Q	0.24
BRCA	chr2	101891272	3'UTR	novel		0.18
BRCA	chr2	101797256	Intron	novel		0.05
BRCA	chr2	101829537	Missense_Mutation	NA	H151Y	0.24
CESC	chr2	101698058	5'Flank	rs780774309		0.18
CESC	chr2	101892319	3'Flank	novel		0.51
CESC	chr2	101885222	Missense_Mutation	NA	L1041V	0.3
CESC	chr2	101839825	Silent	novel	K260K	0.25
CESC	chr2	101831850	Missense_Mutation	novel	R213T	0.34
CESC	chr2	101891269	3'UTR	novel		0.13
CESC	chr2	101891271	3'UTR	novel		0.14
CESC	chr2	101859823	Missense_Mutation	rs760266370	E555K	0.16
CESC	chr2	101867271	Missense_Mutation	NA	E728K	0.14
CESC	chr2	101823969	Silent	novel	K74K	0.35
CESC	chr2	101859946	Intron	novel		0.36
CESC	chr2	101887226	Missense_Mutation	novel	L1109V	0.38
CHOL	chr2	101891720	3'Flank	novel		0.31
CHOL	chr2	101864004	Intron	NA		0.4
COAD	chr2	101891400	3'Flank	novel		0.26
COAD	chr2	101860809	Intron	novel		0.21
COAD	chr2	101866558	Missense_Mutation	rs776570846	G701R	0.22
COAD	chr2	101885251	Missense_Mutation	NA	W1050C	0.34
COAD	chr2	101831813	Missense_Mutation	novel	A201T	0.27
COAD	chr2	101877116	Missense_Mutation	novel	E974K	0.27
COAD	chr2	101859059	Missense_Mutation	novel	L487I	0.05
COAD	chr2	101859883	Intron	novel		0.39
COAD	chr2	101874201	Missense_Mutation	rs375228116	R919C	0.35
COAD	chr2	101864037	Intron	NA		0.38
COAD	chr2	101877066	Missense_Mutation	novel	K957T	0.27
COAD	chr2	101831739	Missense_Mutation	novel	A176D	0.26
COAD	chr2	101867251	Frame_Shift_Del	NA	*N722Mfs3**	0.46
COAD	chr2	101869631	Missense_Mutation	rs199996114	A744T	0.27
COAD	chr2	101863873	Intron	rs752768892		0.32
COAD	chr2	101831743	Missense_Mutation	NA	Q177H	0.24
COAD	chr2	101859774	Silent	NA	Q538Q	0.3
COAD	chr2	101869686	Missense_Mutation	rs770671445	T762M	0.38
COAD	chr2	101870324	Missense_Mutation	rs372783884	T809M	0.25
COAD	chr2	101859030	Missense_Mutation	NA	R477Q	0.13
COAD	chr2	101888824	Silent	NA	G1175G	0.55
COAD	chr2	101891388	3'Flank	novel		0.45
COAD	chr2	101839821	Missense_Mutation	NA	S259L	0.22
COAD	chr2	101891366	3'Flank	novel		0.31
COAD	chr2	101859674	Missense_Mutation	novel	R505L	0.13
COAD	chr2	101885233	Silent	NA	S1044S	0.21
COAD	chr2	101888914	Missense_Mutation	NA	F1205L	0.07
COAD	chr2	101887864	Silent	NA	G1141G	0.36
COAD	chr2	101891184	Missense_Mutation	NA	R1219W	0.33
COAD	chr2	101856025	Nonsense_Mutation	NA	R428*	0.17
COAD	chr2	101698101	Frame_Shift_Del	novel	*S9Vfs62**	0.09
COAD	chr2	101831764	Silent	NA	R184R	0.19
COAD	chr2	101887837	Silent	rs753534395	E1132E	0.2
COAD	chr2	101891184	Missense_Mutation	NA	R1219W	0.27
COAD	chr2	101866433	Missense_Mutation	NA	I659S	0.23
COAD	chr2	101874201	Missense_Mutation	rs375228116	R919C	0.24
COAD	chr2	101888826	Frame_Shift_Del	NA	*G1177Efs5**	0.19
COAD	chr2	101891329	3'Flank	novel		0.16
COAD	chr2	101866557	Silent	rs376560483	S700S	0.47
COAD	chr2	101859699	Silent	NA	Q513Q	0.16
ESCA	chr2	101839961	Missense_Mutation	novel	I306V	0.38
ESCA	chr2	101894596	3'Flank	novel		0.44
ESCA	chr2	101861030	Intron	novel		0.15
ESCA	chr2	101887257	Intron	novel		0.18
ESCA	chr2	101844189	Missense_Mutation	novel	R371W	0.3
GBM	chr2	101823974	Missense_Mutation	NA	Y76F	0.33
GBM	chr2	101866564	Missense_Mutation	rs369479508	R703C	0.29
GBM	chr2	101831831	Missense_Mutation	novel	D207Y	0.29
GBM	chr2	101839928	Nonsense_Mutation	novel	E295*	0.23
GBM	chr2	101877051	Missense_Mutation	novel	R952I	0.34
GBM	chr2	101869756	Silent	NA	G785G	0.73
HNSC	chr2	101835939	Missense_Mutation	novel	I245S	0.23
HNSC	chr2	101888924	Missense_Mutation	novel	R1209C	0.32
HNSC	chr2	101829507	Missense_Mutation	novel	L141V	0.33
HNSC	chr2	101859858	Silent	novel	A566A	0.29
HNSC	chr2	101839987	Silent	NA	G314G	0.21
HNSC	chr2	101866557	Silent	rs376560483	S700S	0.31
KIRC	chr2	101887824	Missense_Mutation	novel	T1128R	0.17
KIRC	chr2	101885202	Missense_Mutation	NA	I1034N	0.19
KIRC	chr2	101844139	Missense_Mutation	NA	R354Q	0.35
KIRC	chr2	101839903	Nonsense_Mutation	novel	*H286_P287insKE**	0.03
KIRC	chr2	101870382	Silent	NA	T828T	0.11
KIRP	chr2	101877130	Silent	rs575144210	V978V	0.3
KIRP	chr2	101891570	3'Flank	novel		0.44
KIRP	chr2	101877082	Silent	NA	I962I	0.6
LAML	chr2	101860937	Missense_Mutation	novel	G606V	0.27
LGG	chr2	101887164	Missense_Mutation	rs778889965	Y1088C	0.13
LGG	chr2	101839954	Missense_Mutation	novel	K303N	0.35
LIHC	chr2	101885212	Silent	novel	L1037L	0.24
LIHC	chr2	101860987	Splice_Site	novel	X622_splice	0.28
LIHC	chr2	101863983	Intron	NA		0.3
LIHC	chr2	101867239	Missense_Mutation	NA	S717C	0.27
LUAD	chr2	101891289	3'UTR	rs769058640		0.15
LUAD	chr2	101869628	Missense_Mutation	novel	T743S	0.38
LUAD	chr2	101885246	Missense_Mutation	novel	A1049P	0.4
LUAD	chr2	101877128	Missense_Mutation	NA	V978I	0.25
LUAD	chr2	101831802	Missense_Mutation	novel	P197H	0.63
LUAD	chr2	101797348	Intron	novel		0.83
LUAD	chr2	101874145	Missense_Mutation	rs375209088	S900L	0.44
LUAD	chr2	101825376	Frame_Shift_Del	novel	*N123Tfs16**	0.22
LUAD	chr2	101859863	Missense_Mutation	NA	E568V	0.2
LUSC	chr2	101864968	Silent	NA	S635S	0.33
LUSC	chr2	101835953	Missense_Mutation	NA	P250S	0.16
LUSC	chr2	101864022	Intron	novel		0.15
LUSC	chr2	101891361	3'Flank	novel		0.36
LUSC	chr2	101882669	Silent	novel	C1023C	0.08
LUSC	chr2	101844275	Silent	NA	I399I	0.19
LUSC	chr2	101882655	Missense_Mutation	NA	D1019N	0.37
LUSC	chr2	101859030	Missense_Mutation	NA	R477Q	0.22
LUSC	chr2	101839919	Nonsense_Mutation	NA	Q292*	0.2
LUSC	chr2	101823977	Missense_Mutation	novel	S77C	0.1
LUSC	chr2	101863994	Intron	rs763083141		0.28
LUSC	chr2	101839937	Missense_Mutation	novel	V298L	0.17
LUSC	chr2	101859030	Missense_Mutation	NA	R477P	0.23
LUSC	chr2	101844137	Silent	NA	R353R	0.43
OV	chr2	101860648	Intron	novel		0.89
OV	chr2	101844297	Silent	novel	R407R	0.09
OV	chr2	101829535	Frame_Shift_Ins	novel	*H151Mfs19**	0.05
OV	chr2	101874129	Missense_Mutation	NA	P895S	0.13
PAAD	chr2	101698535	Frame_Shift_Ins	novel	*R43Sfs4**	0.07
PAAD	chr2	101844253	Missense_Mutation	novel	L392Q	0.08
PRAD	chr2	101870370	Silent	novel	E824E	0.18
PRAD	chr2	101835970	Frame_Shift_Del	rs774203808	*K257Nfs10**	0.5
PRAD	chr2	101888849	Nonsense_Mutation	novel	R1184*	0.16
READ	chr2	101860814	Intron	novel		0.47
READ	chr2	101823988	Missense_Mutation	NA	N81H	0.09
READ	chr2	101825403	Missense_Mutation	NA	A131T	0.43
READ	chr2	101887097	Nonsense_Mutation	NA	E1066*	0.37
READ	chr2	101829580	Missense_Mutation	NA	A165V	0.36
SARC	chr2	101885239	Silent	novel	E1046E	0.44
SARC	chr2	101859854	Missense_Mutation	rs781410462	R565Q	0.82
SARC	chr2	101698538	Missense_Mutation	novel	K41N	0.36
SARC	chr2	101877140	Missense_Mutation	novel	I982V	0.18
SKCM	chr2	101874226	Missense_Mutation	NA	S927F	0.46
SKCM	chr2	101866442	Missense_Mutation	novel	R662K	0.11
SKCM	chr2	101874080	Splice_Site	NA	X879_splice	0.69
SKCM	chr2	101866446	Silent	novel	L663L	0.33
SKCM	chr2	101874201	Missense_Mutation	rs375228116	R919C	0.48
SKCM	chr2	101888849	Nonsense_Mutation	novel	R1184*	0.44
SKCM	chr2	101877028	Frame_Shift_Ins	novel	*S953Kfs30**	0.04
SKCM	chr2	101882627	Silent	NA	E1009E	0.39
SKCM	chr2	101839967	Missense_Mutation	rs779064004	R308C	0.07
SKCM	chr2	101885195	Missense_Mutation	novel	E1032K	0.27
SKCM	chr2	101825413	Missense_Mutation	NA	S134F	0.21
SKCM	chr2	101873670	Silent	NA	L847L	0.21
SKCM	chr2	101863882	Intron	NA		0.52
SKCM	chr2	101829540	Missense_Mutation	NA	R152G	0.56
SKCM	chr2	101844146	Silent	novel	F356F	0.48
SKCM	chr2	101825348	Silent	NA	S112S	0.1
SKCM	chr2	101885233	Silent	novel	S1044S	0.22
SKCM	chr2	101873654	Missense_Mutation	novel	S842F	0.35
SKCM	chr2	101864033	Intron	NA		0.14
SKCM	chr2	101698507	Missense_Mutation	NA	V31G	0.06
SKCM	chr2	101860851	Silent	NA	N577N	0.69
SKCM	chr2	101831787	Missense_Mutation	novel	P192L	0.51
SKCM	chr2	101877032	Missense_Mutation	NA	G946C	0.2
SKCM	chr2	101842630	Missense_Mutation	NA	S324I	0.18
SKCM	chr2	101870380	Missense_Mutation	NA	T828A	0.3
SKCM	chr2	101825355	Missense_Mutation	NA	D115N	0.15
SKCM	chr2	101887905	Missense_Mutation	NA	V1155A	0.37
SKCM	chr2	101888814	Missense_Mutation	novel	Q1172L	0.5
SKCM	chr2	101790745	Nonsense_Mutation	NA	L50*	0.33
SKCM	chr2	101860932	Silent	novel	S604S	0.2
STAD	chr2	101835969	Frame_Shift_Ins	novel	*W258Mfs7**	0.33
STAD	chr2	101859786	Silent	rs763922718	P542P	0.45
STAD	chr2	101835970	Frame_Shift_Del	novel	*K257Mfs7**	0.22
STAD	chr2	101859780	Silent	rs762602382	P540P	0.23
STAD	chr2	101859753	Silent	rs186857052	P531P	0.47
STAD	chr2	101869719	Missense_Mutation	rs545368433	T773M	0.27
STAD	chr2	101839967	Missense_Mutation	rs779064004	R308C	0.22
STAD	chr2	101859072	Missense_Mutation	novel	A491V	0.41
STAD	chr2	101844282	Frame_Shift_Del	novel	*Q402Gfs2**	0.2
STAD	chr2	101874161	Missense_Mutation	NA	N905K	0.21
STAD	chr2	101844297	Nonsense_Mutation	NA	R407*	0.2
STAD	chr2	101863855	Intron	rs61741756		0.19
STAD	chr2	101882568	Missense_Mutation	NA	R990C	0.17
STAD	chr2	101831801	Frame_Shift_Del	novel	*E198Vfs38**	0.71
STAD	chr2	101835969	Frame_Shift_Ins	novel	*W258Mfs7**	0.32
STAD	chr2	101869669	Silent	NA	R756R	0.29
STAD	chr2	101887797	Missense_Mutation	novel	P1119H	0.2
STAD	chr2	101869706	Missense_Mutation	NA	E769K	0.56
STAD	chr2	101698504	Missense_Mutation	NA	V30A	0.19
THCA	chr2	101882597	Silent	novel	N999N	0.13
THCA	chr2	101865032	Missense_Mutation	novel	T657P	0.2
THCA	chr2	101834442	Missense_Mutation	NA	E225Q	0.13
UCEC	chr2	101871559	Intron	novel		0.35
UCEC	chr2	101891388	3'Flank	novel		0.24
UCEC	chr2	101894409	3'Flank	novel		0.39
UCEC	chr2	101859916	Intron	novel		0.39
UCEC	chr2	101891386	3'Flank	novel		0.36
UCEC	chr2	101856119	Missense_Mutation	novel	R459M	0.22
UCEC	chr2	101894576	3'Flank	novel		0.35
UCEC	chr2	101892198	3'Flank	novel		0.3
UCEC	chr2	101869713	Missense_Mutation	novel	S771L	0.45
UCEC	chr2	101855993	Missense_Mutation	novel	R417L	0.41
UCEC	chr2	101860885	Missense_Mutation	novel	G589C	0.06
UCEC	chr2	101885274	Missense_Mutation	NA	F1058C	0.4
UCEC	chr2	101844115	Missense_Mutation	novel	V346A	0.33
UCEC	chr2	101863922	Intron	novel		0.4
UCEC	chr2	101864036	Intron	rs754674926		0.36
UCEC	chr2	101874234	Silent	rs577039991	L930L	0.37
UCEC	chr2	101698515	Missense_Mutation	novel	G34C	0.07
UCEC	chr2	101860975	Missense_Mutation	novel	A619T	0.34
UCEC	chr2	101869735	Silent	rs760805317	D778D	0.31
UCEC	chr2	101888914	Missense_Mutation	NA	F1205L	0.32
UCEC	chr2	101885274	Missense_Mutation	NA	F1058C	0.06
UCEC	chr2	101887802	Missense_Mutation	rs575872758	A1121T	0.23
UCEC	chr2	101891653	3'Flank	novel		0.11
UCEC	chr2	101855988	Silent	NA	R415R	0.41
UCEC	chr2	101892198	3'Flank	novel		0.51
UCEC	chr2	101888818	Silent	novel	T1173T	0.32
UCEC	chr2	101891386	3'Flank	novel		0.39
UCEC	chr2	101839988	Missense_Mutation	NA	E315K	0.59
UCEC	chr2	101865037	Splice_Site	NA	X658_splice	0.37
UCEC	chr2	101869767	Frame_Shift_Del	novel	*T790Pfs13**	0.16
UCEC	chr2	101860667	Intron	novel		0.4
UCEC	chr2	101892691	3'Flank	novel		0.23
UCEC	chr2	101844270	Missense_Mutation	novel	R398W	0.47
UCEC	chr2	101894547	3'Flank	novel		0.16
UCEC	chr2	101861073	Intron	novel		0.27
UCEC	chr2	101891628	3'Flank	novel		0.23
UCEC	chr2	101839987	Silent	NA	G314G	0.38
UCEC	chr2	101859672	Silent	novel	H504H	0.37
UCEC	chr2	101863934	Intron	novel		0.29
UCEC	chr2	101892751	3'Flank	novel		0.54
UCEC	chr2	101894230	3'Flank	novel		0.41
UCEC	chr2	101859859	Nonsense_Mutation	novel	R567*	0.41
UCEC	chr2	101860745	Intron	novel		0.26
UCEC	chr2	101892439	3'Flank	novel		0.17
UCEC	chr2	101871531	Intron	novel		0.32
UCEC	chr2	101892040	3'Flank	novel		0.47
UCEC	chr2	101859797	Missense_Mutation	NA	R546M	0.29
UCEC	chr2	101887162	Silent	novel	I1087I	0.45
UCEC	chr2	101870324	Missense_Mutation	rs372783884	T809M	0.3
UCEC	chr2	101882647	Missense_Mutation	novel	T1016S	0.37
UCEC	chr2	101825333	Silent	novel	F107F	0.41
UCEC	chr2	101874097	Missense_Mutation	novel	D884A	0.38
UCEC	chr2	101698126	Missense_Mutation	novel	S16P	0.42
UCEC	chr2	101869730	Missense_Mutation	novel	E777K	0.35
UCEC	chr2	101892198	3'Flank	novel		0.6
UCEC	chr2	101844300	Frame_Shift_Ins	NA	*E411Gfs2**	0.37
UCEC	chr2	101869738	Silent	rs551450744	D779D	0.23
UCEC	chr2	101892529	3'Flank	novel		0.1
UCEC	chr2	101894596	3'Flank	novel		0.36
UCEC	chr2	101790723	Nonsense_Mutation	novel	R43*	0.22
UCEC	chr2	101844270	Missense_Mutation	novel	R398W	0.38
UCEC	chr2	101894464	3'Flank	novel		0.17
UCEC	chr2	101888924	Missense_Mutation	novel	R1209C	0.33
UCEC	chr2	101790724	Missense_Mutation	NA	R43Q	0.33
UCEC	chr2	101870406	Silent	NA	I836I	0.57
UCEC	chr2	101894596	3'Flank	novel		0.28
UCEC	chr2	101797296	Intron	novel		0.37
UCEC	chr2	101824010	Missense_Mutation	NA	A88V	0.12
UCEC	chr2	101835909	Missense_Mutation	novel	D235G	0.42
UCEC	chr2	101870401	Missense_Mutation	novel	L835I	0.67
UCEC	chr2	101888931	Missense_Mutation	novel	D1211G	0.35
UCEC	chr2	101829504	Nonsense_Mutation	NA	G140*	0.04
UCEC	chr2	101839822	Silent	rs369276793	S259S	0.38
UCEC	chr2	101835970	Frame_Shift_Del	rs774203808	*K257Nfs10**	0.42
UCEC	chr2	101892203	3'Flank	novel		0.13
UCEC	chr2	101874135	Missense_Mutation	rs781009612	R897W	0.03
UCEC	chr2	101859744	Silent	novel	H528H	0.08
UCEC	chr2	101835959	Missense_Mutation	NA	R252W	0.1
UCEC	chr2	101844297	Nonsense_Mutation	NA	R407*	0.13
UCEC	chr2	101871556	Intron	novel		0.09
UCEC	chr2	101894477	3'Flank	novel		0.34
UCEC	chr2	101894383	3'Flank	novel		0.3
UCEC	chr2	101856101	Missense_Mutation	NA	R453Q	0.18
UCEC	chr2	101892400	3'Flank	novel		0.27
UCEC	chr2	101894465	3'Flank	novel		0.38
UCEC	chr2	101892198	3'Flank	novel		0.33
UCEC	chr2	101839866	Missense_Mutation	NA	Y274C	0.07
UCEC	chr2	101797251	Intron	novel		0.19
UCEC	chr2	101869630	Silent	rs750583925	T743T	0.26
UCEC	chr2	101894596	3'Flank	novel		0.45
UCEC	chr2	101860926	Silent	novel	S602S	0.11
UCEC	chr2	101835917	Missense_Mutation	novel	P238S	0.14
UCEC	chr2	101859741	Silent	novel	D527D	0.5
UCEC	chr2	101882567	Silent	novel	L989L	0.21
UCEC	chr2	101891328	3'Flank	novel		0.19
UCEC	chr2	101864012	Intron	NA		0.35
UCEC	chr2	101866469	Missense_Mutation	NA	L671P	0.16
UCEC	chr2	101867245	Missense_Mutation	rs768378384	R719H	0.1
UCEC	chr2	101825333	Silent	novel	F107F	0.38
UCEC	chr2	101863949	Intron	novel		0.47
UCEC	chr2	101874203	Silent	novel	R919R	0.42
UCEC	chr2	101891617	3'Flank	novel		0.33
UCEC	chr2	101891747	3'Flank	novel		0.38
UCEC	chr2	101825391	Nonsense_Mutation	novel	E127*	0.3
UCEC	chr2	101831781	Missense_Mutation	novel	G190D	0.4
UCEC	chr2	101867257	Missense_Mutation	novel	A723V	0.4
UCEC	chr2	101871512	Intron	novel		0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1667	0.15279
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0044	Kaplan-Meier Survival Analysis
STAD	0.0042	Kaplan-Meier Survival Analysis
SARC	0.00032	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00089	Kaplan-Meier Survival Analysis
HNSC	0.0073	Kaplan-Meier Survival Analysis
KIRP	0.0015	Kaplan-Meier Survival Analysis
PAAD	0.0019	Kaplan-Meier Survival Analysis
BLCA	0.0087	Kaplan-Meier Survival Analysis
CESC	0.012	Kaplan-Meier Survival Analysis
LAML	0.0024	Kaplan-Meier Survival Analysis
LIHC	0.027	Kaplan-Meier Survival Analysis
LGG	0.024	Kaplan-Meier Survival Analysis
LUAD	0.0049	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000071054 (Gene tree)
Gene ID: 9448
Gene Symbol: MAP4K4
Alias: HGK|NIK|FLH21957
Full Name: mitogen-activated protein kinase kinase kinase kinase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 197,841 bases
Position: chr2:101,696,850-101,894,690
Accession: 6866
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30200638	RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.	Int J Mol Sci	2018 Sep 6	Peng HY	doi: 10.3390/ijms19092646.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496989	MAP4K4-217	574	-	-	- (aa)	-	-
ENST00000476609	MAP4K4-213	3598	-	-	- (aa)	-	-
ENST00000302217	MAP4K4-201	6624	-	ENSP00000303600	987 (aa)	-	C9J840
ENST00000347699	MAP4K4-203	3792	XM_005264069	ENSP00000314363	1239 (aa)	XP_005264126	O95819
ENST00000498066	MAP4K4-218	1017	-	-	- (aa)	-	-
ENST00000491743	MAP4K4-216	646	-	-	- (aa)	-	-
ENST00000477711	MAP4K4-214	606	-	-	- (aa)	-	-
ENST00000627726	MAP4K4-220	3135	-	ENSP00000487176	1044 (aa)	-	A0A0D9SG62
ENST00000634702	MAP4K4-221	3800	XM_005264050	ENSP00000489579	1165 (aa)	XP_005264107	O95819
ENST00000413150	MAP4K4-206	6958	XM_005264071	ENSP00000389752	1154 (aa)	XP_005264128	E7ENQ1
ENST00000324219	MAP4K4-202	7526	XM_017005350	ENSP00000313644	1235 (aa)	XP_016860839	G5E948
ENST00000427603	MAP4K4-211	526	-	ENSP00000403016	102 (aa)	-	E7ETN6
ENST00000417294	MAP4K4-207	4251	-	ENSP00000409720	1170 (aa)	-	H7C360
ENST00000625522	MAP4K4-219	7458	XM_005264048	ENSP00000486116	1320 (aa)	XP_005264105	A0A0D9SEY1
ENST00000421882	MAP4K4-209	3416	-	ENSP00000396066	1056 (aa)	-	H7C0P6
ENST00000425019	MAP4K4-210	4403	XM_005264060	ENSP00000392830	1272 (aa)	XP_005264117	E7EN19
ENST00000350198	MAP4K4-204	7316	XM_017005373	ENSP00000281111	1165 (aa)	XP_016860862	G3XAA2
ENST00000350878	MAP4K4-205	7640	XM_005264057	ENSP00000343658	1273 (aa)	XP_005264114	O95819
ENST00000489490	MAP4K4-215	362	-	-	- (aa)	-	-
ENST00000456652	MAP4K4-212	3855	-	ENSP00000387370	1038 (aa)	-	E7EX83
ENST00000418101	MAP4K4-208	776	-	ENSP00000414766	258 (aa)	-	H7C3Z6

Gene Model

Click here to download ENSG00000071054's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000071054	rs34043159	2	101796654	C	Parkinson's disease	28892059	[1.06-1.10]	1.08	EFO_0002508
ENSG00000071054	rs77657034	2	101857264	G	Alzheimer's disease	30636644	[3.02-10.81]	6.912992	EFO_0000249
ENSG00000071054	rs6543087	2	101699471	?	White blood cell count	30595370			EFO_0004308
ENSG00000071054	rs115567723	2	101746707	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000071054	rs111955202	2	101788512	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000071054's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000071054	MAP4K4	100	100.000	ENSMUSG00000026074	Map4k4	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	21873635.	IBA	Process
GO:0001953	negative regulation of cell-matrix adhesion	25490267.	NAS	Process
GO:0004111	creatine kinase activity	23207904.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9890973.	IDA	Function
GO:0005515	protein binding	12387898.14966141.	IPI	Function
GO:0005524	ATP binding	9890973.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	14966141.	IDA	Component
GO:0005925	focal adhesion	25490267.	IDA	Component
GO:0006468	protein phosphorylation	9890973.	IDA	Process
GO:0008017	microtubule binding	25490267.	IDA	Function
GO:0023014	signal transduction by protein phosphorylation	21873635.	IBA	Process
GO:0030033	microvillus assembly	22797597.	IMP	Process
GO:0030335	positive regulation of cell migration	24163766.	IMP	Process
GO:0031098	stress-activated protein kinase signaling cascade	21873635.	IBA	Process
GO:0032014	positive regulation of ARF protein signal transduction	25490267.	ISS	Process
GO:0032147	activation of protein kinase activity	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	9890973.	IDA	Process
GO:0043066	negative regulation of apoptotic process	21196414.	IMP	Process
GO:0043547	positive regulation of GTPase activity	25490267.	ISS	Process
GO:0046328	regulation of JNK cascade	14966141.	IDA	Process
GO:0048812	neuron projection morphogenesis	21873635.	IBA	Process
GO:0051549	positive regulation of keratinocyte migration	25490267.	ISS	Process
GO:0051894	positive regulation of focal adhesion assembly	25490267.	ISS	Process
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	Process
GO:0070571	negative regulation of neuron projection regeneration	-	IEA	Process
GO:1903393	positive regulation of adherens junction organization	25490267.	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.