EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30352438	Overexpression of KIF2A is Suppressed by miR-206 and Associated with Poor Prognosis in Ovarian Cancer.	Cell Physiol Biochem	2018	Sheng N	doi: 10.1159/000494467
24950762	KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.	BMC Cancer	2014 Jun 21	Wang J	doi: 10.1186/1471-2407-14-461.
25002494	Ras transformation uncouples the kinesin-coordinated cellular nutrient response.	Proc Natl Acad Sci U S A	2014 Jul 22	Zaganjor E	doi: 10.1073/pnas.1411016111
27773961	KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.	Dis Markers	2016	Zhang S	-
26070867	KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.	Tumour Biol	2015 Nov	Fan X	doi: 10.1007/s13277-015-3603-z
28061449	Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.	Oncotarget	2017 Feb 14	Wolter P	doi: 10.18632/oncotarget.14466.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	62373834	Missense_Mutation	NA	Q598H	0.17
BLCA	chr5	62353292	Missense_Mutation	novel	C159G	0.5
BLCA	chr5	62381208	Missense_Mutation	novel	E664K	0.29
BLCA	chr5	62353331	Missense_Mutation	novel	K172E	0.67
BRCA	chr5	62348096	Missense_Mutation	NA	E70K	0.38
BRCA	chr5	62357710	Missense_Mutation	NA	C225Y	0.36
BRCA	chr5	62372466	Intron	NA		0.49
BRCA	chr5	62348070	Missense_Mutation	rs767638932	S61L	0.17
BRCA	chr5	62347137	Missense_Mutation	NA	I24M	0.35
BRCA	chr5	62361511	Nonsense_Mutation	novel	G337*	0.08
BRCA	chr5	62362535	Silent	novel	S371S	0.21
BRCA	chr5	62373694	Nonsense_Mutation	NA	E552*	0.27
BRCA	chr5	62381149	Missense_Mutation	NA	A644V	0.45
CESC	chr5	62385965	3'Flank	rs145403929		0.39
CESC	chr5	62385860	3'Flank	novel		0.2
CESC	chr5	62348065	Missense_Mutation	NA	I59M	0.19
CESC	chr5	62372532	Intron	NA		0.23
COAD	chr5	62385496	Missense_Mutation	NA	S683Y	0.43
COAD	chr5	62362453	Missense_Mutation	novel	R344Q	0.07
COAD	chr5	62363841	Missense_Mutation	novel	A470V	0.58
COAD	chr5	62373762	Silent	novel	I574I	0.34
COAD	chr5	62357708	Frame_Shift_Ins	NA	R229*	0.59
COAD	chr5	62381143	Frame_Shift_Del	NA	*K643Rfs4**	0.2
COAD	chr5	62350073	Missense_Mutation	novel	R96Q	0.28
COAD	chr5	62372532	Intron	NA		0.31
COAD	chr5	62355181	Missense_Mutation	novel	N194I	0.08
COAD	chr5	62363733	Missense_Mutation	NA	R434Q	0.34
ESCA	chr5	62365322	Missense_Mutation	novel	S516C	0.07
ESCA	chr5	62385907	3'Flank	rs200992864		0.26
GBM	chr5	62355191	Silent	novel	I197I	0.07
GBM	chr5	62365343	Missense_Mutation	novel	R523H	0.45
GBM	chr5	62358147	Missense_Mutation	novel	M240I	0.18
GBM	chr5	62362475	Missense_Mutation	novel	K351N	0.6
HNSC	chr5	62363727	Nonsense_Mutation	novel	S432*	0.53
KICH	chr5	62357727	Nonsense_Mutation	rs750318761	R231*	0.63
KIRC	chr5	62381191	Missense_Mutation	NA	S658L	0.41
KIRC	chr5	62348084	Missense_Mutation	NA	L66I	0.17
KIRP	chr5	62366477	Missense_Mutation	NA	N548Y	0.23
LIHC	chr5	62373686	Splice_Site	NA	X549_splice	0.48
LIHC	chr5	62385490	Missense_Mutation	novel	V681E	0.25
LUAD	chr5	62381128	Missense_Mutation	novel	R637Q	0.48
LUSC	chr5	62350106	Missense_Mutation	novel	S107L	0.26
LUSC	chr5	62363794	Frame_Shift_Del	novel	*L455Ifs30**	0.64
LUSC	chr5	62352615	Missense_Mutation	NA	S121I	0.35
LUSC	chr5	62373811	Missense_Mutation	novel	D591Y	0.27
LUSC	chr5	62385496	Missense_Mutation	NA	S683C	0.33
LUSC	chr5	62348061	Missense_Mutation	rs757038674	S58N	0.34
LUSC	chr5	62357716	Missense_Mutation	novel	C227F	0.21
OV	chr5	62373726	Silent	novel	D562D	0.09
PRAD	chr5	62381230	Frame_Shift_Del	novel	*I671Kfs4**	0.33
READ	chr5	62372497	Intron	rs780183716		0.15
READ	chr5	62363241	Nonsense_Mutation	NA	Q395*	0.26
READ	chr5	62357728	Missense_Mutation	NA	R231Q	0.38
READ	chr5	62348140	Silent	NA	S84S	0.32
SKCM	chr5	62358250	Missense_Mutation	NA	R275C	0.45
SKCM	chr5	62358250	Missense_Mutation	NA	R275C	0.14
SKCM	chr5	62363198	Silent	rs774313950	R380R	0.25
SKCM	chr5	62373730	Missense_Mutation	rs771417898	R564C	0.18
SKCM	chr5	62381136	Missense_Mutation	novel	E640K	0.25
SKCM	chr5	62363266	Missense_Mutation	NA	E403G	0.19
SKCM	chr5	62347157	Missense_Mutation	NA	S31F	0.22
SKCM	chr5	62352710	Missense_Mutation	novel	S153T	0.12
SKCM	chr5	62372529	Intron	novel		0.67
SKCM	chr5	62352708	Missense_Mutation	NA	P152L	0.35
SKCM	chr5	62352704	Missense_Mutation	NA	P151S	0.28
STAD	chr5	62347173	Silent	novel	N36N	0.23
STAD	chr5	62363705	Missense_Mutation	NA	Q425E	0.45
STAD	chr5	62385571	3'UTR	novel		0.36
STAD	chr5	62348157	Missense_Mutation	NA	K90T	0.28
STAD	chr5	62373694	Nonsense_Mutation	NA	E552*	0.28
STAD	chr5	62358202	Missense_Mutation	novel	P259S	0.15
STAD	chr5	62352688	Frame_Shift_Del	novel	*K147Rfs14**	0.39
STAD	chr5	62373709	Missense_Mutation	NA	P557T	0.17
STAD	chr5	62381251	Frame_Shift_Del	novel		0.09
STAD	chr5	62363733	Missense_Mutation	NA	R434Q	0.24
STAD	chr5	62347151	Missense_Mutation	NA	V29A	0.55
STAD	chr5	62363842	Silent	rs754391420	A470A	0.46
THCA	chr5	62348143	Silent	NA	S85S	0.06
UCEC	chr5	62381251	Missense_Mutation	rs777345819	R678Q	0.32
UCEC	chr5	62385677	3'Flank	novel		0.35
UCEC	chr5	62385953	3'Flank	novel		0.13
UCEC	chr5	62386258	3'Flank	novel		0.41
UCEC	chr5	62385650	3'UTR	novel		0.36
UCEC	chr5	62381171	Silent	novel	E651E	0.37
UCEC	chr5	62363314	Missense_Mutation	novel	S419N	0.3
UCEC	chr5	62357708	Missense_Mutation	novel	I224M	0.31
UCEC	chr5	62348109	Missense_Mutation	NA	P74L	0.46
UCEC	chr5	62385765	3'Flank	novel		0.27
UCEC	chr5	62348052	Missense_Mutation	novel	D55G	0.2
UCEC	chr5	62381212	Missense_Mutation	novel	A665G	0.06
UCEC	chr5	62363702	Missense_Mutation	NA	G424S	0.23
UCEC	chr5	62386212	3'Flank	novel		0.41
UCEC	chr5	62355207	Missense_Mutation	novel	D203Y	0.51
UCEC	chr5	62358179	Missense_Mutation	novel	K251T	0.09
UCEC	chr5	62373704	Missense_Mutation	novel	V555A	0.36
UCEC	chr5	62386115	3'Flank	novel		0.1
UCEC	chr5	62385753	3'Flank	novel		0.25
UCEC	chr5	62372497	Intron	rs780183716		0.29
UCEC	chr5	62363834	Missense_Mutation	novel	S468P	0.33
UCEC	chr5	62353338	Missense_Mutation	novel	R174K	0.38
UCEC	chr5	62357710	Missense_Mutation	NA	C225Y	0.46
UCEC	chr5	62386313	3'Flank	novel		0.24
UCEC	chr5	62373766	Missense_Mutation	novel	D576N	0.4
UCEC	chr5	62372479	Intron	NA		0.49
UCEC	chr5	62352649	Missense_Mutation	novel	Q132H	0.12
UCEC	chr5	62358151	Missense_Mutation	NA	D242Y	0.14
UCEC	chr5	62358269	Missense_Mutation	novel	D281G	0.27
UCEC	chr5	62353320	Frame_Shift_Del	novel	*K169Nfs32**	0.32
UCEC	chr5	62358286	Missense_Mutation	NA	E287K	0.37
UCEC	chr5	62381127	Missense_Mutation	rs764372768	R637W	0.33
UCEC	chr5	62385685	3'Flank	novel		0.3
UCEC	chr5	62386100	3'Flank	novel		0.31
UCEC	chr5	62385541	Missense_Mutation	novel	I698S	0.06
UCEC	chr5	62352699	Missense_Mutation	novel	F149C	0.35
UCEC	chr5	62372531	Intron	NA		0.21
UCEC	chr5	62362475	Missense_Mutation	novel	K351N	0.17
UCEC	chr5	62385943	3'Flank	novel		0.15
UCEC	chr5	62352628	Silent	novel	E125E	0.4
UCEC	chr5	62353318	Missense_Mutation	NA	Q167H	0.25
UCEC	chr5	62363746	Silent	NA	V438V	0.32
UCEC	chr5	62373823	Missense_Mutation	NA	L595I	0.15
UCEC	chr5	62385898	3'Flank	novel		0.05
UCEC	chr5	62357720	Silent	novel	V228V	0.29
UCEC	chr5	62358290	Missense_Mutation	novel	M288T	0.16
UCEC	chr5	62362452	Nonsense_Mutation	novel	R344*	0.44
UCEC	chr5	62373704	Missense_Mutation	novel	V555A	0.38
UCEC	chr5	62350069	Nonsense_Mutation	novel	R95*	0.31
UCEC	chr5	62352665	Missense_Mutation	novel	D138Y	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2333	1.1352e-11
CHOL	DEL	0.2222	0.16947
MESO	DEL	0.1149	0.20184
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
SARC	0.035	Kaplan-Meier Survival Analysis
MESO	0.0017	Kaplan-Meier Survival Analysis
ACC	0.007	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
BRCA	0.035	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
COAD	0.0014	Kaplan-Meier Survival Analysis
PCPG	0.045	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
KICH	0.0028	Kaplan-Meier Survival Analysis
GBM	0.038	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000068796 (Gene tree)
Gene ID: 3796
Gene Symbol: KIF2A
Alias: HK2|KIF2
Full Name: kinesin family member 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 231,088 bases
Position: chr5:62,306,162-62,537,249
Accession: 6318
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30195762	LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.	Mol Ther Nucleic Acids	2018 Sep 7	Barbagallo C	doi: 10.1016/j.omtn.2018.05.009

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000509663	KIF2A-207	759	-	-	- (aa)	-	-
ENST00000512541	KIF2A-209	549	-	ENSP00000425411	80 (aa)	-	D6RD93
ENST00000504883	KIF2A-204	783	-	-	- (aa)	-	-
ENST00000506857	KIF2A-205	2219	-	ENSP00000423772	660 (aa)	-	O00139
ENST00000381103	KIF2A-201	3360	-	ENSP00000370493	686 (aa)	-	O00139
ENST00000509624	KIF2A-206	293	-	-	- (aa)	-	-
ENST00000401507	KIF2A-202	2539	-	ENSP00000385622	706 (aa)	-	O00139
ENST00000514082	KIF2A-210	874	-	ENSP00000423542	284 (aa)	-	D6R9M0
ENST00000407818	KIF2A-203	2315	-	ENSP00000385000	744 (aa)	-	O00139
ENST00000512006	KIF2A-208	392	-	ENSP00000421041	130 (aa)	-	H0Y8H2

Gene Model

Click here to download ENSG00000068796's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000068796	Platelet Function Tests	4.4300000E-006	-
ENSG00000068796	Platelet Function Tests	2.2800222E-006	-
ENSG00000068796	Platelet Function Tests	3.0144562E-006	-
ENSG00000068796	Platelet Function Tests	2.3975593E-006	-
ENSG00000068796	Platelet Function Tests	7.0891383E-007	-
ENSG00000068796	Platelet Function Tests	1.3181453E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000068796	rs40110	5	62468025	A	Diffusing capacity of the lung for carbon monoxide traits	30049742	[0.013-0.027] unit increase	0.02	EFO_0009369

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068796's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	26323690.	IGI	Process
GO:0000922	spindle pole	18411309.	IDA	Component
GO:0003774	motor activity	9177777.	TAS	Function
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005515	protein binding	18411309.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	26323690.	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005814	centriole	23213374.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	26323690.	IDA	Component
GO:0005876	spindle microtubule	18411309.	IDA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007018	microtubule-based movement	-	TAS	Process
GO:0007019	microtubule depolymerization	26323690.	TAS	Process
GO:0007052	mitotic spindle organization	18411309.	IDA	Process
GO:0007399	nervous system development	-	IEA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008017	microtubule binding	26323690.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0030334	regulation of cell migration	26323690.	IGI	Process
GO:0051301	cell division	-	IEA	Process
GO:0090307	mitotic spindle assembly	15843429.	IMP	Process
GO:0097228	sperm principal piece	-	IEA	Component
GO:0120103	centriolar subdistal appendage	23213374.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.