EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30352438Overexpression of KIF2A is Suppressed by miR-206 and Associated with Poor Prognosis in Ovarian Cancer.Cell Physiol Biochem2018Sheng Ndoi: 10.1159/000494467
24950762KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.BMC Cancer2014 Jun 21Wang Jdoi: 10.1186/1471-2407-14-461.
25002494Ras transformation uncouples the kinesin-coordinated cellular nutrient response.Proc Natl Acad Sci U S A2014 Jul 22Zaganjor Edoi: 10.1073/pnas.1411016111
27773961KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.Dis Markers2016Zhang S-
26070867KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.Tumour Biol2015 NovFan Xdoi: 10.1007/s13277-015-3603-z
28061449Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.Oncotarget2017 Feb 14Wolter Pdoi: 10.18632/oncotarget.14466.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr562373834Missense_MutationNAQ598H0.17
BLCAchr562353292Missense_MutationnovelC159G0.5
BLCAchr562381208Missense_MutationnovelE664K0.29
BLCAchr562353331Missense_MutationnovelK172E0.67
BRCAchr562348096Missense_MutationNAE70K0.38
BRCAchr562357710Missense_MutationNAC225Y0.36
BRCAchr562372466IntronNA0.49
BRCAchr562348070Missense_Mutationrs767638932S61L0.17
BRCAchr562347137Missense_MutationNAI24M0.35
BRCAchr562361511Nonsense_MutationnovelG337*0.08
BRCAchr562362535SilentnovelS371S0.21
BRCAchr562373694Nonsense_MutationNAE552*0.27
BRCAchr562381149Missense_MutationNAA644V0.45
CESCchr5623859653'Flankrs1454039290.39
CESCchr5623858603'Flanknovel0.2
CESCchr562348065Missense_MutationNAI59M0.19
CESCchr562372532IntronNA0.23
COADchr562385496Missense_MutationNAS683Y0.43
COADchr562362453Missense_MutationnovelR344Q0.07
COADchr562363841Missense_MutationnovelA470V0.58
COADchr562373762SilentnovelI574I0.34
COADchr562357708Frame_Shift_InsNAR229*0.59
COADchr562381143Frame_Shift_DelNAK643Rfs*40.2
COADchr562350073Missense_MutationnovelR96Q0.28
COADchr562372532IntronNA0.31
COADchr562355181Missense_MutationnovelN194I0.08
COADchr562363733Missense_MutationNAR434Q0.34
ESCAchr562365322Missense_MutationnovelS516C0.07
ESCAchr5623859073'Flankrs2009928640.26
GBMchr562355191SilentnovelI197I0.07
GBMchr562365343Missense_MutationnovelR523H0.45
GBMchr562358147Missense_MutationnovelM240I0.18
GBMchr562362475Missense_MutationnovelK351N0.6
HNSCchr562363727Nonsense_MutationnovelS432*0.53
KICHchr562357727Nonsense_Mutationrs750318761R231*0.63
KIRCchr562381191Missense_MutationNAS658L0.41
KIRCchr562348084Missense_MutationNAL66I0.17
KIRPchr562366477Missense_MutationNAN548Y0.23
LIHCchr562373686Splice_SiteNAX549_splice0.48
LIHCchr562385490Missense_MutationnovelV681E0.25
LUADchr562381128Missense_MutationnovelR637Q0.48
LUSCchr562350106Missense_MutationnovelS107L0.26
LUSCchr562363794Frame_Shift_DelnovelL455Ifs*300.64
LUSCchr562352615Missense_MutationNAS121I0.35
LUSCchr562373811Missense_MutationnovelD591Y0.27
LUSCchr562385496Missense_MutationNAS683C0.33
LUSCchr562348061Missense_Mutationrs757038674S58N0.34
LUSCchr562357716Missense_MutationnovelC227F0.21
OVchr562373726SilentnovelD562D0.09
PRADchr562381230Frame_Shift_DelnovelI671Kfs*40.33
READchr562372497Intronrs7801837160.15
READchr562363241Nonsense_MutationNAQ395*0.26
READchr562357728Missense_MutationNAR231Q0.38
READchr562348140SilentNAS84S0.32
SKCMchr562358250Missense_MutationNAR275C0.45
SKCMchr562358250Missense_MutationNAR275C0.14
SKCMchr562363198Silentrs774313950R380R0.25
SKCMchr562373730Missense_Mutationrs771417898R564C0.18
SKCMchr562381136Missense_MutationnovelE640K0.25
SKCMchr562363266Missense_MutationNAE403G0.19
SKCMchr562347157Missense_MutationNAS31F0.22
SKCMchr562352710Missense_MutationnovelS153T0.12
SKCMchr562372529Intronnovel0.67
SKCMchr562352708Missense_MutationNAP152L0.35
SKCMchr562352704Missense_MutationNAP151S0.28
STADchr562347173SilentnovelN36N0.23
STADchr562363705Missense_MutationNAQ425E0.45
STADchr5623855713'UTRnovel0.36
STADchr562348157Missense_MutationNAK90T0.28
STADchr562373694Nonsense_MutationNAE552*0.28
STADchr562358202Missense_MutationnovelP259S0.15
STADchr562352688Frame_Shift_DelnovelK147Rfs*140.39
STADchr562373709Missense_MutationNAP557T0.17
STADchr562381251Frame_Shift_Delnovel0.09
STADchr562363733Missense_MutationNAR434Q0.24
STADchr562347151Missense_MutationNAV29A0.55
STADchr562363842Silentrs754391420A470A0.46
THCAchr562348143SilentNAS85S0.06
UCECchr562381251Missense_Mutationrs777345819R678Q0.32
UCECchr5623856773'Flanknovel0.35
UCECchr5623859533'Flanknovel0.13
UCECchr5623862583'Flanknovel0.41
UCECchr5623856503'UTRnovel0.36
UCECchr562381171SilentnovelE651E0.37
UCECchr562363314Missense_MutationnovelS419N0.3
UCECchr562357708Missense_MutationnovelI224M0.31
UCECchr562348109Missense_MutationNAP74L0.46
UCECchr5623857653'Flanknovel0.27
UCECchr562348052Missense_MutationnovelD55G0.2
UCECchr562381212Missense_MutationnovelA665G0.06
UCECchr562363702Missense_MutationNAG424S0.23
UCECchr5623862123'Flanknovel0.41
UCECchr562355207Missense_MutationnovelD203Y0.51
UCECchr562358179Missense_MutationnovelK251T0.09
UCECchr562373704Missense_MutationnovelV555A0.36
UCECchr5623861153'Flanknovel0.1
UCECchr5623857533'Flanknovel0.25
UCECchr562372497Intronrs7801837160.29
UCECchr562363834Missense_MutationnovelS468P0.33
UCECchr562353338Missense_MutationnovelR174K0.38
UCECchr562357710Missense_MutationNAC225Y0.46
UCECchr5623863133'Flanknovel0.24
UCECchr562373766Missense_MutationnovelD576N0.4
UCECchr562372479IntronNA0.49
UCECchr562352649Missense_MutationnovelQ132H0.12
UCECchr562358151Missense_MutationNAD242Y0.14
UCECchr562358269Missense_MutationnovelD281G0.27
UCECchr562353320Frame_Shift_DelnovelK169Nfs*320.32
UCECchr562358286Missense_MutationNAE287K0.37
UCECchr562381127Missense_Mutationrs764372768R637W0.33
UCECchr5623856853'Flanknovel0.3
UCECchr5623861003'Flanknovel0.31
UCECchr562385541Missense_MutationnovelI698S0.06
UCECchr562352699Missense_MutationnovelF149C0.35
UCECchr562372531IntronNA0.21
UCECchr562362475Missense_MutationnovelK351N0.17
UCECchr5623859433'Flanknovel0.15
UCECchr562352628SilentnovelE125E0.4
UCECchr562353318Missense_MutationNAQ167H0.25
UCECchr562363746SilentNAV438V0.32
UCECchr562373823Missense_MutationNAL595I0.15
UCECchr5623858983'Flanknovel0.05
UCECchr562357720SilentnovelV228V0.29
UCECchr562358290Missense_MutationnovelM288T0.16
UCECchr562362452Nonsense_MutationnovelR344*0.44
UCECchr562373704Missense_MutationnovelV555A0.38
UCECchr562350069Nonsense_MutationnovelR95*0.31
UCECchr562352665Missense_MutationnovelD138Y0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.23331.1352e-11
CHOLDEL0.22220.16947
MESODEL0.11490.20184
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
SARC0.035

Kaplan-Meier Survival Analysis

MESO0.0017

Kaplan-Meier Survival Analysis

ACC0.007

Kaplan-Meier Survival Analysis

LUSC0.013

Kaplan-Meier Survival Analysis

BRCA0.035

Kaplan-Meier Survival Analysis

KIRP0.013

Kaplan-Meier Survival Analysis

COAD0.0014

Kaplan-Meier Survival Analysis

PCPG0.045

Kaplan-Meier Survival Analysis

READ0.015

Kaplan-Meier Survival Analysis

KICH0.0028

Kaplan-Meier Survival Analysis

GBM0.038

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

CHOL0.026

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000068796 (Gene tree)
Gene ID
3796
Gene Symbol
KIF2A
Alias
HK2|KIF2
Full Name
kinesin family member 2A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
231,088 bases
Position
chr5:62,306,162-62,537,249
Accession
6318
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30195762LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.Mol Ther Nucleic Acids2018 Sep 7Barbagallo Cdoi: 10.1016/j.omtn.2018.05.009
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000509663KIF2A-207759--- (aa)--
ENST00000512541KIF2A-209549-ENSP0000042541180 (aa)-D6RD93
ENST00000504883KIF2A-204783--- (aa)--
ENST00000506857KIF2A-2052219-ENSP00000423772660 (aa)-O00139
ENST00000381103KIF2A-2013360-ENSP00000370493686 (aa)-O00139
ENST00000509624KIF2A-206293--- (aa)--
ENST00000401507KIF2A-2022539-ENSP00000385622706 (aa)-O00139
ENST00000514082KIF2A-210874-ENSP00000423542284 (aa)-D6R9M0
ENST00000407818KIF2A-2032315-ENSP00000385000744 (aa)-O00139
ENST00000512006KIF2A-208392-ENSP00000421041130 (aa)-H0Y8H2
Gene Model
Click here to download ENSG00000068796's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000068796Platelet Function Tests4.4300000E-006-
ENSG00000068796Platelet Function Tests2.2800222E-006-
ENSG00000068796Platelet Function Tests3.0144562E-006-
ENSG00000068796Platelet Function Tests2.3975593E-006-
ENSG00000068796Platelet Function Tests7.0891383E-007-
ENSG00000068796Platelet Function Tests1.3181453E-006-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000068796rs40110562468025ADiffusing capacity of the lung for carbon monoxide traits30049742[0.013-0.027] unit increase0.02EFO_0009369
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068796's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000226microtubule cytoskeleton organization26323690.IGIProcess
GO:0000922spindle pole18411309.IDAComponent
GO:0003774motor activity9177777.TASFunction
GO:0003777microtubule motor activity21873635.IBAFunction
GO:0005515protein binding18411309.25416956.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus-IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm26323690.IDAComponent
GO:0005813centrosome21873635.IBAComponent
GO:0005813centrosome21399614.IDAComponent
GO:0005814centriole23213374.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005871kinesin complex21873635.IBAComponent
GO:0005874microtubule21873635.IBAComponent
GO:0005874microtubule26323690.IDAComponent
GO:0005876spindle microtubule18411309.IDAComponent
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TASProcess
GO:0007018microtubule-based movement21873635.IBAProcess
GO:0007018microtubule-based movement-TASProcess
GO:0007019microtubule depolymerization26323690.TASProcess
GO:0007052mitotic spindle organization18411309.IDAProcess
GO:0007399nervous system development-IEAProcess
GO:0008017microtubule binding21873635.IBAFunction
GO:0008017microtubule binding26323690.IDAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016604nuclear body-IDAComponent
GO:0016887ATPase activity21873635.IBAFunction
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TASProcess
GO:0030154cell differentiation-IEAProcess
GO:0030334regulation of cell migration26323690.IGIProcess
GO:0051301cell division-IEAProcess
GO:0090307mitotic spindle assembly15843429.IMPProcess
GO:0097228sperm principal piece-IEAComponent
GO:0120103centriolar subdistal appendage23213374.IDAComponent
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